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4. Dupilumab improves health‐related quality of life in patients with chronic rhinosinusitis with nasal polyposis

Author

Bachert, Claus, primary, Hellings, Peter W., additional, Mullol, Joaquim, additional, Hamilos, Daniel L., additional, Gevaert, Philippe, additional, Naclerio, Robert M., additional, Joish, Vijay N., additional, Chao, Jingdong, additional, Mannent, Leda P., additional, Amin, Nikhil, additional, Abbe, Adeline, additional, Taniou, Christine, additional, Fan, Chunpeng, additional, Pirozzi, Gianluca, additional, Graham, Neil M. H., additional, Mahajan, Puneet, additional, Staudinger, Heribert, additional, and Khan, Asif, additional

Published
2019
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5. Dupilumab improves symptoms, quality of life, and productivity in uncontrolled persistent asthma

Author

Corren, Jonathan, primary, Castro, Mario, additional, Chanez, Pascal, additional, Fabbri, Leonardo, additional, Joish, Vijay N., additional, Amin, Nikhil, additional, Graham, Neil M.H., additional, Mastey, Vera, additional, Abbé, Adeline, additional, Taniou, Christine, additional, Mahajan, Puneet, additional, Teper, Ariel, additional, Pirozzi, Gianluca, additional, and Eckert, Laurent, additional

Published
2019
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6. Dupilumab improves SNOT-22 scores in asthma patients with chronic rhinosinusitis or nasal polypsosis (CRS/NP) in LIBERTY ASTHMA QUEST

Author

Busse, William, primary, Maspero, Jorge F., additional, Katelaris, Contance H., additional, Saralaya, Dinesh, additional, Guillonneau, Sophie, additional, Zhang, Bingzhi, additional, Taniou, Christine, additional, Staudinger, Heribert, additional, Chao, Jingdong, additional, Amin, Nikhil, additional, Pirozzi, Gianluca, additional, Ruddy, Marcella, additional, Akinlade, Bolanle, additional, Graham, Neil M. H., additional, Teper, Ariel, additional, and Khan, Asif, additional

Published
2018
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8. Dupilumab improves asthma-related patient reported outcomes in asthma patients with chronic rhinosinusitis or nasal polyposis (CRS/NP) in LIBERTY ASTHMA QUEST

Author

Corren, Jonathan, primary, Castro, Mario, additional, Maspero, Jorge F., additional, Valero Santiago, Antonio L., additional, Kuna, Piotr, additional, Guillonneau, Sophie, additional, Dong, Qunming, additional, Taniou, Christine, additional, Staudinger, Heribert, additional, Chao, Jingdong, additional, Amin, Nikhil, additional, Pirozzi, Gianluca, additional, Ruddy, Marcella, additional, Akinlade, Bolanle, additional, Graham, Neil M. H., additional, Teper, Ariel, additional, and Khan, Asif, additional

Published
2018
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9. Dupilumab improves health‐related quality of life in patients with chronic rhinosinusitis with nasal polyposis.

Author

Bachert, Claus, Hellings, Peter W., Mullol, Joaquim, Hamilos, Daniel L., Gevaert, Philippe, Naclerio, Robert M., Joish, Vijay N., Chao, Jingdong, Mannent, Leda P., Amin, Nikhil, Abbe, Adeline, Taniou, Christine, Fan, Chunpeng, Pirozzi, Gianluca, Graham, Neil M. H., Mahajan, Puneet, Staudinger, Heribert, and Khan, Asif

Subjects
NASAL polyps, QUALITY of life, SICK leave, CLINICAL trial registries, SINUSITIS
Abstract

Background: Chronic rhinosinusitis with nasal polyposis (CRSwNP) negatively affects health‐related quality of life (HRQoL). In a previously reported randomized clinical trial (NCT01920893), addition of dupilumab to mometasone furoate in patients with CRSwNP refractory to intranasal corticosteroids (INCS) significantly improved endoscopic, radiographic, and clinical endpoints and patient‐reported outcomes. The objective of this analysis was to examine the impact of dupilumab treatment on HRQoL and productivity using secondary outcome data from this trial. Methods: Following a 4‐week mometasone furoate nasal spray run‐in, patients were randomized to commence subcutaneous dupilumab (600 mg loading dose, then 300 mg once weekly for 15 weeks [n = 30], or matched placebo [n = 30]). Outcomes included scores on the CRS disease severity visual analog scale (VAS), 22‐item Sino‐Nasal Outcome Test (SNOT‐22), 5‐dimension EuroQoL (EQ‐5D) general health status VAS, and 36‐item Short‐Form Health Survey (SF‐36) for HRQoL and nasal polyp‐related healthcare resource use questionnaires. Results: Following 16 weeks of treatment, the proportion of patients with moderate‐to‐severe CRSwNP (VAS > 3‐10) decreased from 86.2% to 21.4% with dupilumab and 88.0% to 84.2% with placebo. Dupilumab (vs placebo) resulted in significantly greater improvement in HRQoL, based on SNOT‐22, SF‐36, and EQ‐5D VAS scores. The dupilumab group had a significantly lower adjusted annualized mean number of sick leave days (0.09, vs 4.18 with placebo, P =.015) and significantly greater improvement (vs placebo) in the SNOT‐22 item "reduced productivity." Conclusions: In adults with CRSwNP refractory to treatment with INCS alone, the addition of dupilumab reduced disease severity, significantly improved HRQoL, and improved productivity. [ABSTRACT FROM AUTHOR]

Published
2020
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10. Dupilumab improves all ACQ-5 individual items in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) and asthma: results from a phase 2a trial

Author

Hellings, Peter, primary, Bachert, Claus, additional, Mullol, Joaquim, additional, Hamilos, Daniel, additional, Naclerio, Robert, additional, Joish, Vijay, additional, Mannent, Leda, additional, Amin, Nikhil, additional, Abbe, Adeline, additional, Taniou, Christine, additional, Pirozzi, Gianluca, additional, Graham, Neil, additional, and Khan, Asif, additional

Published
2017
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11. Dupilumab improves lung function and reduces severe exacerbations in uncontrolled persistent asthma patients with ongoing allergic rhinitis

Author

Weinstein, Steven, primary, Staudinger, Heribert, additional, Guillonneau, Sophie, additional, Taniou, Christine, additional, Eckert, Laurent, additional, Joish, Vijay, additional, Maroni, Jaman, additional, Rowe, Paul, additional, Amin, Nikhil, additional, Pirozzi, Gianluca, additional, Graham, Neil, additional, and Teper, Ariel, additional

Published
2017
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13. Dupilumab improves patient-reported outcomes in chronic sinusitis with nasal polyps patients with comorbid asthma: Results from a phase 2a trial

Author

Bachert, Claus, primary, Hellings, Peter, additional, Mullol, Joaquim, additional, Hamilos, Daniel, additional, Naclerio, Robert, additional, Joish, Vijay N., additional, Mannent, Leda, additional, Evans, Robert E., additional, Grabher, Annette, additional, Abbe, Adeline, additional, Amand, Caroline, additional, Taniou, Christine, additional, Zhang, Donghui, additional, Fan, Chunpeng, additional, Pirozzi, Gianluca, additional, Graham, Neil, additional, Mastey, Vera, additional, Mahajan, Puneet, additional, Staudinger, Heribert, additional, Eckert, Laurent, additional, and Khan, Asif, additional

Published
2016
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14. Dupilumab reduces severe exacerbation-related costs among asthma patients: Results from a phase 2b trial

Author

Corren, Jonathan, primary, Chanez, Pascal, additional, Castro, Mario, additional, Fabbri, Leonardo, additional, Joish, Vijay N., additional, Evans, Robert E., additional, Graham, Neil M.H., additional, Mastey, Vera, additional, Villeneuve, Sara, additional, Bégo-Le Bagousse, Gaëlle, additional, Taniou, Christine, additional, Mahajan, Puneet, additional, Teper, Ariel, additional, Pirozzi, Gianluca, additional, and Eckert, Laurent, additional

Published
2016
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16. Teriflunomide Reduces Relapse-Related Sequelae, Hospitalizations and Corticosteroid Use: A Post-Hoc Analysis of the Phase 3 TOWER Study (P07.109)

Author

O'Connor, Paul, primary, Lublin, Fred, additional, Wolinsky, Jerry, additional, Comi, Giancarlo, additional, Confavreux, Christian, additional, Freedman, Mark, additional, Miller, Aaron, additional, Olsson, Tomas, additional, Dive-Pouletty, Catherine, additional, Taniou, Christine, additional, Selzer, Martin, additional, and Kappos, Ludwig, additional

Published
2013
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