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19 results on '"Tao, Siyue"'

10. Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2

Author

Wei, Xiaoan, primary, Zheng, Zeyu, additional, Feng, Zhenhua, additional, Zheng, Lin, additional, Tao, Siyue, additional, Zheng, Bingjie, additional, Huang, Bao, additional, Zhang, Xuyang, additional, Liu, Junhui, additional, Chen, Yilei, additional, Zong, Wentian, additional, Shan, Zhi, additional, Fan, Shunwu, additional, Chen, Jian, additional, and Zhao, Fengdong, additional

Published
2022
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12. Destabilization of macrophage migration inhibitory factor by 4‐IPP reduces NF‐κB/P‐TEFb complex‐mediated c‐Myb transcription to suppress osteosarcoma tumourigenesis

Author

Zheng, Lin, primary, Feng, Zhenhua, additional, Tao, Siyue, additional, Gao, Jiawei, additional, Lin, Ye, additional, Wei, Xiaoan, additional, Zheng, Bingjie, additional, Huang, Bao, additional, Zheng, Zeyu, additional, Zhang, Xuyang, additional, Liu, Junhui, additional, Shan, Zhi, additional, Chen, Yilei, additional, Chen, Jian, additional, and Zhao, Fengdong, additional

Published
2022
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13. MSX2 Affects Chondrocyte Differentiation by Regulating the Expression of SOX9 and Runx2 in Limbs and Spine Development

Author

Zhang, Xuyang, primary, Jie, Zhiwei, additional, Gan, Kaifeng, additional, Zhang, Qibin, additional, Feng, Zhenhua, additional, Tao, Siyue, additional, Chen, Yilei, additional, Kong, Xiangxi, additional, Xie, Ziang, additional, Wei, Xiao'an, additional, Zheng, Zeyu, additional, Zheng, Bingjie, additional, Huang, Bao, additional, Zheng, Lin, additional, Shan, Zhi, additional, Liu, Junhui, additional, Qin, An, additional, Fan, Shunwu, additional, Chen, Jian, additional, and Zhao, Fengdong, additional

Published
2022
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18. Red Light-Mediated Photoredox Catalysis Triggers Nitric Oxide Release for Treatment of Cutibacterium AcneInduced Intervertebral Disc Degeneration

Author

Tao, Siyue, Shen, Zhiqiang, Chen, Jian, Shan, Zhi, Huang, Bao, Zhang, Xuyang, Zheng, Lin, Liu, Junhui, You, Tao, Zhao, Fengdong, and Hu, Jinming

Abstract

Intervertebral disc degeneration (IVDD) has been known as a highly prevalent and disabling disease, which is one of the main causes of low back pain and disability. Unfortunately, there is no effective cure to treat this formidable disease, and surgical interventions are typically applied. Herein, we report that the local administration of nitric oxide (NO)-releasing micellar nanoparticles can efficiently treat IVDD associated with Modic changes in a rat model established by infection with Cutibacterium acnes(C. acnes). By covalent incorporation of palladium(II) meso-tetraphenyltetrabenzoporphyrin photocatalyst and coumarin-based NO donors into the core of micellar nanoparticles, we demonstrate that the activation of the UV-absorbing coumarin-based NO donors can be achieved under red light irradiation via photoredox catalysis, although it remains a great challenge to implement photoredox catalysis reactions in biological conditions due to the complex microenvironments. Notably, the local delivery of NO can not only efficiently eradicate C. acnespathogens but also inhibit the inflammatory response and osteoclast differentiation in the intervertebral disc tissues, exerting antibacterial, anti-inflammatory, and antiosteoclastogenesis effects. This work provides a feasible means to efficiently treat IVDD by the local administration of NO signaling molecules without resorting to a surgical approach.

Published
2022
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19. Breathing Micelles for Combinatorial Treatment of Rheumatoid Arthritis.

Author

Tao S, Cheng J, Su G, Li D, Shen Z, Tao F, You T, and Hu J

Subjects
Animals, Anti-Inflammatory Agents, Non-Steroidal chemistry, Arthritis, Rheumatoid metabolism, Breath Tests, Carbon Monoxide administration & dosage, Carbon Monoxide metabolism, Dexamethasone chemistry, Inhalation Exposure, Lipopolysaccharides antagonists & inhibitors, Lipopolysaccharides pharmacology, Macrophages drug effects, Macrophages metabolism, Mice, Micelles, Molecular Structure, Nitric Oxide administration & dosage, Nitric Oxide biosynthesis, Particle Size, RAW 264.7 Cells, Surface Properties, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Arthritis, Rheumatoid drug therapy, Carbon Monoxide antagonists & inhibitors, Dexamethasone pharmacology, Nitric Oxide antagonists & inhibitors
Abstract

Breathing process involves inhalation and exhalation of different gases in animals. The gas exchange of the breathing process plays a critical role in maintaining the physiological functions of living organisms. Although artificial breathing materials exhibiting volume expansion and contraction upon alternate exposure to different gases have been well explored, those being able to realize the gas exchange remain elusive. Herein, we report breathing micelles (BM) capable of inhaling nitric oxide (NO) and exhaling carbon monoxide (CO), both of which are endogenous gaseous signaling molecules. We demonstrate that BM can simultaneously scavenge overproduced NO and attenuate proinflammatory cytokines in lipopolysaccharide (LPS)-challenged macrophage cells. In vivo studies revealed that BM outperformed conventional nonsteroidal anti-inflammatory drugs such as dexamethasone (Dexa) in treatment of rheumatoid arthritis (RA) in adjuvant-induced arthritis (AIA) rats, likely due to the combinatorial effect of NO depletion, CO-mediated deactivation of inducible NO synthase (iNOS) and activation of heme oxygenase-1 (HO-1). This work provides new insights into artificial BM for potential biomedical applications., (© 2020 Wiley-VCH GmbH.)

Published
2020
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