Search

Your search keyword '"Tarantini, Letizia"' showing total 401 results
Start Over Author "Tarantini, Letizia"
401 results on '"Tarantini, Letizia"'

7. Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

Author

Chambers, John C, Loh, Marie, Lehne, Benjamin, Drong, Alexander, Kriebel, Jennifer, Motta, Valeria, Wahl, Simone, Elliott, Hannah R, Rota, Federica, Scott, William R, Zhang, Weihua, Tan, Sian-Tsung, Campanella, Gianluca, Chadeau-Hyam, Marc, Yengo, Loic, Richmond, Rebecca C, Adamowicz-Brice, Martyna, Afzal, Uzma, Bozaoglu, Kiymet, Mok, Zuan Yu, Ng, Hong Kiat, Pattou, François, Prokisch, Holger, Rozario, Michelle Ann, Tarantini, Letizia, Abbott, James, Ala-Korpela, Mika, Albetti, Benedetta, Ammerpohl, Ole, Bertazzi, Pier Alberto, Blancher, Christine, Caiazzo, Robert, Danesh, John, Gaunt, Tom R, de Lusignan, Simon, Gieger, Christian, Illig, Thomas, Jha, Sujeet, Jones, Simon, Jowett, Jeremy, Kangas, Antti J, Kasturiratne, Anuradhani, Kato, Norihiro, Kotea, Navaratnam, Kowlessur, Sudhir, Pitkäniemi, Janne, Punjabi, Prakash, Saleheen, Danish, Schafmayer, Clemens, Soininen, Pasi, Tai, E-Shyong, Thorand, Barbara, Tuomilehto, Jaakko, Wickremasinghe, Ananda Rajitha, Kyrtopoulos, Soterios A, Aitman, Timothy J, Herder, Christian, Hampe, Jochen, Cauchi, Stéphane, Relton, Caroline L, Froguel, Philippe, Soong, Richie, Vineis, Paolo, Jarvelin, Marjo-Riitta, Scott, James, Grallert, Harald, Bollati, Valentina, Elliott, Paul, McCarthy, Mark I, and Kooner, Jaspal S

Published
2015
Full Text
View/download PDF

13. Let-7a Downregulation Accompanied by KRAS Mutation Is Predictive of Lung Cancer Onset in Cigarette Smoke–Exposed Mice.

Author

Pulliero, Alessandra, Mastracci, Luca, Tarantini, Letizia, Khalid, Zumama, Bollati, Valentina, and Izzotti, Alberto

Subjects
RAS oncogenes, LUNG cancer, CIGARETTES, MICE, DOWNREGULATION, ONCOGENES, P16 gene
Abstract

Background: Let-7 is a tumor suppressor microRNA targeting the KRAS lung oncogene. Let-7a downregulation is reversible during the early stages of lung carcinogenesis but is irreversible in cancer cells. The aim of this study is to shed light on the relationship between oncogene (KRAS) mutation and let-7a downregulation in cigarette smoke (CS)-induced lung carcinogenesis. Methods: A total of 184 strain H Swiss albino mice were either unexposed (control) or exposed to CS for 2 weeks (short CS) or 8 months (long CS). After 8 months, the lungs were individually collected. The following end points have been evaluated: (a) DNA methylation of the let-7a gene promoter by bisulphite-PCR and pyrosequencing; (b) let-7a expression by qPCR; (c) KRAS mutation by DNA pyrosequencing; (d) cancer incidence by histopathological examination. Results: let-7a expression decreased by 8.3% in the mice exposed to CS for two weeks (CS short) and by 33.4% (p ≤ 0.01) in the mice exposed to CS for 8 months (CS long). No significant difference was detected in the rate of let-7a-promoter methylation between the Sham-exposed mice (55.1%) and the CS short-(53%) or CS long (51%)-exposed mice. The percentage of G/T transversions in KRAS codons 12 and 13 increased from 2.3% (Sham) to 6.4% in CS short– and to 11.5% in CS long–exposed mice. Cancer incidence increased significantly in the CS long–exposed mice (11%) as compared to both the Sham (4%) and the CS short–exposed (2%) mice. In the CS long–exposed mice, the correlation between let-7a expression and the number of KRAS mutations was positive (R = +0.5506) in the cancer-free mice and negative (R = −0.5568) in the cancer-bearing mice. Conclusions: The effects of CS-induced mutations in KRAS are neutralized by the high expression of let-7a in cancer-free mice (positive correlation) but not in cancer-bearing mice where an irreversible let-7a downregulation occurs (negative correlation). This result provides evidence that both genetic (high load of KRAS mutation) and epigenetic alterations (let-7a irreversible downregulation) are required to produce lung cancer in CS-exposed organisms. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

27. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Author

Wahl, Simone, Drong, Alexander, Lehne, Benjamin, Loh, Marie, Scott, William R., Kunze, Sonja, Tsai, Pei-Chien, Ried, Janina S., Zhang, Weihua, Yang, Youwen, Tan, Sili, Fiorito, Giovanni, Franke, Lude, Guarrera, Simonetta, Kasela, Silva, Kriebel, Jennifer, Richmond, Rebecca C., Adamo, Marco, Afzal, Uzma, Ala-Korpela, Mika, Albetti, Benedetta, Ammerpohl, Ole, Apperley, Jane F., Beekman, Marian, Bertazzi, Pier Alberto, Black, Lucas S., Blancher, Christine, Bonder, Marc-Jan, Brosch, Mario, Carstensen-Kirberg, Maren, de Craen, Anton J. M., de Lusignan, Simon, Dehghan, Abbas, Elkalaawy, Mohamed, Fischer, Krista, Franco, Oscar H., Gaunt, Tom R., Hampe, Jochen, Hashemi, Majid, Isaacs, Aaron, Jenkinson, Andrew, Jha, Sujeet, Kato, Norihiro, Krogh, Vittorio, Laffan, Michael, Meisinger, Christa, Meitinger, Thomas, Mok, Zuan Yu, Motta, Valeria, Ng, Hong Kiat, Nikolakopoulou, Zacharoula, Nteliopoulos, Georgios, Panico, Salvatore, Pervjakova, Natalia, Prokisch, Holger, Rathmann, Wolfgang, Roden, Michael, Rota, Federica, Rozario, Michelle Ann, Sandling, Johanna K., Schafmayer, Clemens, Schramm, Katharina, Siebert, Reiner, Slagboom, Eline P., Soininen, Pasi, Stolk, Lisette, Strauch, Konstantin, Tai, E-Shyong, Tarantini, Letizia, Thorand, Barbara, Tigchelaar, Ettje F., Tumino, Rosario, Uitterlinden, Andre G., van Duijn, Cornelia, van Meurs, Joyce B. J., Vineis, Paolo, Wickremasinghe, Ananda Rajitha, Wijmenga, Cisca, Yang, Tsun-Po, Yuan, Wei, Zhernakova, Alexandra, Batterham, Rachel L., Smith, George Davey, Deloukas, Panos, Heijmans, Bastiaan T., Herder, Christian, Hofman, Albert, Lindgren, Cecilia M., Milani, Lili, van der Harst, Pim, Peters, Annette, Illig, Thomas, Relton, Caroline L., Waldenberger, Melanie, Jürvelin, Marjo-Riitta, Bollati, Valentina, Soong, Richie, Spector, Tim D., Scott, James, McCarthy, Mark I., Elliott, Paul, Bell, Jordana T., Matullo, Giuseppe, Gieger, Christian, Kooner, Jaspal S., Grallert, Harald, and Chambers, John C.

Published
2017
Full Text
View/download PDF

29. SARS-CoV-2 infection among asymptomatic homebound subjects in Milan, Italy

Author

Milani, Gregorio Paolo, Montomoli, Emanuele, Bollati, Valentina, Albetti, Benedetta, Bandi, Claudio, Bellini, Tommaso, Bonzini, Matteo, Buscaglia, Marco, Cantarella, Carlo, Cantone, Laura, Carugno, Michele, Casartelli, Sergio, Cavaletti, Guido, D'Alessandro, Sarah, De Chiara, Francesca, Delbue, Serena, Dioni, Laura, Eberini, Ivano, Favero, Chiara, Ferrari, Luca, Ferraroni, Monica, Galastri, Laura, Galli, Cristina, Hoxha, Mirjam, Iodice, Simona, La Vecchia, Carlo, Macchi, Chiara, Manini, Ilaria, Marchi, Serena, Mariani, Jacopo, Pariani, Elena, Pesatori, Angela Cecilia, Rota, Federica, Ruscica, Massimiliano, Schioppo, Tommaso, Tarantini, Letizia, Trombetta, Claudia Maria, Valsecchi, Maria Grazia, Vicenzi, Marco, and Zanchetta, Giuliano

Published
2020
Full Text
View/download PDF

31. Human Endogenous Retroviruses Long Terminal Repeat Methylation, Transcription, and Protein Expression in Human Colon Cancer

Author

Dolci, Maria, Favero, Chiara, Toumi, Wafa, Favi, Evaldo, Tarantini, Letizia, Signorini, Lucia, Basile, Giuseppe, Bollati, Valentina, D'Alessandro, Sarah, Bagnoli, Pietro, Ferrante, Pasquale, and Delbue, Serena

Subjects
Oncology, colon cancer, viruses, embryonic structures, HERV elements, human endogenous retroviruses, methylation, HERV expression, Original Research
Abstract

Colon cancer is the fourth most common malignancy in both incidence and mortality in developed countries. Infectious agents are among the risk factors for colon cancer. Variations in human endogenous retrovirus (HERV) transcript and protein levels are associated with several types of cancers, but few studies address HERV expression in colon cancer. Fifty-eight patients with advanced-stage colon cancer were enrolled in this study. HERV-H, -K (HML-2), -P LTRs, Alu, and LINE-1 methylation levels and transcription of HERV-H, -K (HML-2), and -P env and HERV-K pol genes in normal adjacent and tumor tissues were investigated by pyrosequencing and RT-qPCR, respectively. Expression of the HERV-K (HML-2) Pol and Env proteins in selected tissues was examined by Western blotting. Associations between HERV transcript expression and methylation levels and between clinical characteristics and HERV expression were evaluated. Compared to adjacent normal tissues, LINE-1 was hypomethylated in tumor tissues (p < 0.05), whereas Alu, HERV-K (HML-2), and -H LTRs showed a decreasing trend in tumor tissue compared to normal tissue, though without a significant difference. The transcription levels of HERV env and pol genes were similar. However, the HERV-K (HML-2) Pol protein was more highly expressed (p < 0.01) in surrounding normal tissues, but the HERV-K (HML-2) Env protein was only expressed in tumor tissues. Although HERV LTR methylation and gene expression did not show significant differences between tumor and normal tissues, HERV protein expression differed greatly. Pol protein expression in normal cells may induce reverse transcription and subsequent integration into the host genome, likely favoring cell transformation; in contrast, the Env protein in tumor tissue may contribute to cancer progression through cell-to-cell fusion.

Published
2020

32. Stress Modifies the Expression of Glucocorticoid-Responsive Genes by Acting at Epigenetic Levels in the Rat Prefrontal Cortex: Modulatory Activity of Lurasidone

Author

Brivio, Paola, primary, Sbrini, Giulia, additional, Tarantini, Letizia, additional, Parravicini, Chiara, additional, Gruca, Piotr, additional, Lason, Magdalena, additional, Litwa, Ewa, additional, Favero, Chiara, additional, Riva, Marco Andrea, additional, Eberini, Ivano, additional, Papp, Mariusz, additional, Bollati, Valentina, additional, and Calabrese, Francesca, additional

Published
2021
Full Text
View/download PDF

40. Assessment of Human Papillomavirus in Lung Tumor Tissue

Author

Koshiol, Jill, Rotunno, Melissa, Gillison, Maura L., Van Doorn, Leen-Jan, Chaturvedi, Anil K., Tarantini, Letizia, Song, Hebin, Quint, Wim G. V., Struijk, Linda, Goldstein, Alisa M., Hildesheim, Allan, Taylor, Philip R., Wacholder, Sholom, Bertazzi, Pietro Alberto, Landi, Maria Teresa, and Caporaso, Neil E.

Published
2011
Full Text
View/download PDF

45. Beyond the mean: quantile regression to explore the association of air pollution with gene-specific methylation in the normative aging study

Author

Bind, Marie-Abele C., Coull, Brent A., Peters, Annette, Baccarelli, Andrea A., Tarantini, Letizia, Cantone, Laura, Vokonas, Pantel S., Koutrakis, Petros, and Schwartz, Joel D.

Subjects
Genetic aspects, Health aspects, Environmental aspects, Air pollution -- Genetic aspects -- Health aspects, Aging (Biology) -- Environmental aspects -- Health aspects -- Genetic aspects, Methylation -- Health aspects -- Environmental aspects, Aging -- Environmental aspects -- Health aspects -- Genetic aspects
Abstract

Introduction Air pollution affects people every day and especially the elderly, who are a growing population stratum in the United States. Mechanisms by which air pollution causes cardiovascular mortality and [...], BACKGROUND: Air pollution has been related to mean changes in outcomes, including DNA methylation. However, mean regression analyses may not capture associations that occur primarily in the tails of the outcome distribution. OBJECTIVES: In this study, we examined whether the association between particulate air pollution and DNA methylation differs across quantiles of the methylation distribution. We focused on methylation of candidate genes related to coagulation and inflammation: coagulation factor III (F3), intercellular adhesion molecule 1 (ICAM-1), interferon gamma (IFN-γ), interleukin-6 (IL-6), and toll-like receptor 2 (TRL-2). METHODS: We measured gene-specific blood DNA methylation repeatedly in 777 elderly men participating in the Normative Aging Study (1999-2010). We fit quantile regressions for longitudinal data to investigate whether the associations of particle number, [PM.sub.2.5] (diameter [less than or equal to] 2.5 µm) black carbon, and [PM.sub.2.5] mass concentrations (4-week moving average) with DNA methylation [expressed as the percentage of methylated cytosines over the sum of methylated and unmethylated cytosines at position 5 (%5mC)] varied across deciles of the methylation distribution. We reported the quantile regression coefficients that corresponded to absolute differences in DNA methylation (expressed in %5mC) associated with an interquartile range increase in air pollution concentration. RESULTS: Interquartile range increases in particle number, [PM.sub.2.5] black carbon, and [PM.sub.2.5] mass concentrations were associated with significantly lower methylation in the lower tails of the IFN-γ and ICAM-1 methylation distributions. For instance, a 3.4-pg/[m.sup.3] increase in [PM.sub.2.5] mass concentration was associated with a 0.18%5mC (95% CI: -0.30, -0.06) decrease on the 20th percentile of ICAM-1 methylation, but was not significantly related to the 80th percentile (estimate: 0.07%5mC, 95% CI: -0.09, 0.24). CONCLUSIONS: In our study population of older men, air pollution exposures were associated with a left shift in the lower tails of the IFN-γ and ICAM-1 methylation distributions.

Published
2015
Full Text
View/download PDF

47. Extracellular Vesicles Released by Colorectal Cancer Cell Lines Modulate Innate Immune Response in Zebrafish Model: The Possible Role of Human Endogenous Retroviruses

Author

Ferrari, Luca, primary, Cafora, Marco, additional, Rota, Federica, additional, Hoxha, Mirjam, additional, Iodice, Simona, additional, Tarantini, Letizia, additional, Dolci, Maria, additional, Delbue, Serena, additional, Pistocchi, Anna, additional, and Bollati, Valentina, additional

Published
2019
Full Text
View/download PDF

50. O4A.1 Night shiftwork, dna methylation, and telomere length in female nurses

Author

Carugno, Michele, primary, Crespi, Eleonora, additional, Bollati, Valentina, additional, Tarantini, Letizia, additional, Dioni, Laura, additional, Ferrari, Luca, additional, Bonzini, Matteo, additional, Consonni, Dario, additional, Maggioni, Cristina, additional, Costa, Giovanni, additional, and Pesatori, Angela Cecilia, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results