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19 results on '"Tarimo, Brian B."'

5. Real-time PCR detection of mixed Plasmodium ovale curtisi and wallikeri infections in human and mosquito hosts

Author

Potlapalli, Varun R., primary, Muller, Meredith S., additional, Ngasala, Billy, additional, Ali, Innocent Mbulli, additional, Na, Yu Bin, additional, Williams, Danielle R., additional, Kharabora, Oksana, additional, Chhetri, Srijana, additional, Liu, Mei S., additional, Carey-Ewend, Kelly, additional, Lin, Feng-Chang, additional, Mathias, Derrick, additional, Tarimo, Brian B., additional, Juliano, Jonathan J., additional, Parr, Jonathan B., additional, and Lin, Jessica T., additional

Published
2023
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8. Real-time PCR detection of mixed Plasmodium ovale curtisi and wallikeri species infections in human and mosquito hosts

Author

Potlapalli, Varun, primary, Muller, Meredith S., additional, Ngasala, Billy, additional, Ali, Innocent Mbulli, additional, Na, Yu Bin, additional, Williams, Danielle R., additional, Kharabora, Oksana, additional, Chhetri, Srijana, additional, Lu, Mei S., additional, Carey-Ewend, Kelly, additional, Lin, Feng-Chang, additional, Mathias, Derrick, additional, Tarimo, Brian B., additional, Juliano, Jonathan J., additional, Parr, Jonathan, additional, and Lin, Jessica T, additional

Published
2023
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11. Outdoor Vector Biting, Feeding on Animal and Pyrethroid Resistance Potential Drivers of Persistent Malaria Transmission in Zanzibar

Author

Musiba, Revocatus Musyangi, primary, Tarimo, Brian B., additional, Monroe, April, additional, Msaky, Dickson, additional, Ngowo, Halfan, additional, Mihayo, Kimberly, additional, Limwagu, Alex, additional, Chila, Godlove T., additional, Shubis, Gasper K., additional, Ibrahim, Ahmada, additional, Greer, George, additional, Mcha, Juma H., additional, Abbas, Faiza, additional, Ali, Abdullah, additional, Okumu, Fredros O, additional, and Kiware, Samson, additional

Published
2022
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12. Proceedings of an expert workshop on community agreement for gene drive research in Africa - Co-organised by KEMRI, PAMCA and Target Malaria

Author

Thizy, Delphine, primary, Pare Toe, Lea, additional, Mbogo, Charles, additional, Matoke-Muhia, Damaris, additional, Alibu, Vincent Pius, additional, Barnhill-Dilling, S. Kathleen, additional, Chantler, Tracey, additional, Chongwe, Gershom, additional, Delborne, Jason, additional, Kapiriri, Lydia, additional, Nassonko Kavuma, Esther, additional, Koloi-Keaikitse, Sethlomo, additional, Kormos, Ana, additional, Littler, Katherine, additional, Lwetoijera, Dickson, additional, Vargas de Moraes, Roberta, additional, Mumba, Noni, additional, Mutengu, Lilian, additional, Mwichuli, Sylvia, additional, Nabukenya, Silvia Elizabeth, additional, Nakigudde, Janet, additional, Ndebele, Paul, additional, Ngara, Carolyne, additional, Ochomo, Eric, additional, Odiwuor Ondiek, Simon, additional, Rivera, Stephany, additional, Roberts, Aaron J., additional, Robinson, Benjamin, additional, Sambakunsi, Rodrick, additional, Saxena, Abha, additional, Sykes, Naima, additional, Tarimo, Brian B., additional, Tiffin, Nicki, additional, and Tountas, Karen H., additional

Published
2021
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13. Patterns of human exposure to malaria vectors in Zanzibar and implications for malaria elimination efforts

Author

Monroe, April, primary, Msaky, Dickson, additional, Kiware, Samson, additional, Tarimo, Brian B., additional, Moore, Sarah, additional, Haji, Khamis, additional, Koenker, Hannah, additional, Harvey, Steven, additional, Finda, Marceline, additional, Ngowo, Halfan, additional, Mihayo, Kimberly, additional, Greer, George, additional, Ali, Abdullah, additional, and Okumu, Fredros, additional

Published
2020
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14. Cytochrome P450/ABC transporter inhibition simultaneously enhances ivermectin pharmacokinetics in the mammal host and pharmacodynamics in Anopheles gambiae

Author

Chaccour, Carlos J., primary, Hammann, Felix, additional, Alustiza, Marta, additional, Castejon, Sandra, additional, Tarimo, Brian B., additional, Abizanda, Gloria, additional, Irigoyen Barrio, Ángel, additional, Martí Soler, Helena, additional, Moncada, Rafael, additional, Bilbao, José Ignacio, additional, Aldaz, Azucena, additional, Maia, Marta, additional, and Del Pozo, José Luis, additional

Published
2017
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17. The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparumSexual Stage Transmission

Author

Balaich, Jared N., Mathias, Derrick K., Torto, Baldwyn, Jackson, Bryan T., Tao, Dingyin, Ebrahimi, Babak, Tarimo, Brian B., Cheseto, Xavier, Foster, Woodbridge A., and Dinglasan, Rhoel R.

Abstract

ABSTRACTParthenin and parthenolide are natural products that are closely related in structure to artemisinin, which is also a sesquiterpene lactone (SQL) and one of the most important antimalarial drugs available. Parthenin, like artemisinin, has an effect on Plasmodiumblood stage development. We extended the evaluation of parthenin as a potential therapeutic for the transmissible stages of Plasmodium falciparumas it transitions between human and mosquito, with the aim of gaining potential mechanistic insight into the inhibitory activity of this compound. We posited that if parthenin targets different biological pathways in the parasite, this in turn could pave the way for the development of druggable compounds that could prevent the spread of artemisinin-resistant parasites. We examined parthenin's effect on male gamete activation and the ookinete-to-oocyst transition in the mosquito as well as on stage V gametocytes that are present in peripheral blood. Parthenin arrested parasite development for each of the stages tested. The broad inhibitory properties of parthenin on the evaluated parasite stages may suggest different mechanisms of action between parthenin and artemisinin. Parthenin's cytotoxicity notwithstanding, its demonstrated activity in this study suggests that structurally related SQLs with a better safety profile deserve further exploration. We used our battery of assays to test parthenolide, which has a more compelling safety profile. Parthenolide demonstrated activity nearly identical to that of parthenin against P. falciparum, highlighting its potential as a possible transmission-blocking drug scaffold. We discuss the context of the evidence with respect to the next steps toward expanding the current antimalarial arsenal.

Published
2016
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19. Real-time PCR detection of mixed Plasmodium ovale curtisi and wallikeri species infections in human and mosquito hosts.

Author

Potlapalli V, Muller MS, Ngasala B, Ali IM, Na YB, Williams DR, Kharabora O, Chhetri S, Liu MS, Carey-Ewend K, Lin FC, Mathias D, Tarimo BB, Juliano JJ, Parr J, and Lin JT

Abstract

Plasmodium ovale curtisi (Poc) and Plasmodium ovale wallikeri (Pow) represent distinct non-recombining malaria species that are increasing in prevalence in sub-Saharan Africa. Though they circulate sympatrically, co-infection within human and mosquito hosts has rarely been described. Separate 18S rRNA real-time PCR assays that detect Poc and Pow were modified to allow species determination in parallel under identical cycling conditions. The lower limit of detection was 0.6 plasmid copies/μL (95% CI 0.4-1.6) for Poc and 4.5 plasmid copies/μL (95% CI( 2.7- 18) for Pow , or 0.1 and 0.8 parasites/μL, respectively, assuming 6 copies of 18s rRNA per genome. However, the assays showed cross-reactivity at concentrations greater than 10 3 plasmid copies/μL (roughly 200 parasites/μL). Mock mixtures were used to establish criteria for classifying mixed Poc/Pow infections that prevented false-positive detection while maintaining sensitive detection of the minority ovale species down to 10° copies/μL (<1 parasite/μL). When the modified real-time PCR assays were applied to field-collected blood samples from Tanzania and Cameroon, species identification by real-time PCR was concordant with nested PCR, but additionally detected two mixed Poc/Pow infections where nested PCR detected a single Po species. When real-time PCR was applied to 14 oocyst-positive Anopheles midguts saved from mosquitoes fed on P. ovate -infected persons, mixed Poc/Pow infections were detected in 11 (79%). Based on these results, 8/9 P. ovate carriers transmitted both P. ovate species to mosquitoes, though both Po species could only be detected in the blood of two carriers. The described real-time PCR approach can be used to identify the natural occurrence of mixed Poc/Pow infections in human and mosquito hosts and reveals that such co-infections and co-transmission are likely more common than appreciated.

Published
2023
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