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424 results on '"Tariq, Raseen"'

7. Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience

Author

Cheng, Yao-Wen, Phelps, Emmalee, Ganapini, Vincent, Khan, Noor, Ouyang, Fangqian, Xu, Huiping, Khanna, Sahil, Tariq, Raseen, Friedman-Moraco, Rachel J, Woodworth, Michael H, Dhere, Tanvi, Kraft, Colleen S, Kao, Dina, Smith, Justin, Le, Lien, El-Nachef, Najwa, Kaur, Nirmal, Kowsika, Sree, Ehrlich, Adam, Smith, Michael, Safdar, Nasia, Misch, Elizabeth Ann, Allegretti, Jessica R, Flynn, Ann, Kassam, Zain, Sharfuddin, Asif, Vuppalanchi, Raj, and Fischer, Monika

Subjects
Clinical Research, Transplantation, Vaccine Related, Biodefense, Prevention, Emerging Infectious Diseases, Infectious Diseases, Organ Transplantation, Patient Safety, Digestive Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Clostridioides difficile, Clostridium Infections, Fecal Microbiota Transplantation, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Recurrence, Retrospective Studies, Transplant Recipients, Treatment Outcome, United States, clinical research, practice, complication: infectious, immunosuppression, immune modulation, infection and infectious agents - bacterial: Clostridium difficile, infectious disease, intestinal disease: infectious, organ transplantation in general, patient safety, clinical research/practice, immunosuppression/immune modulation, Medical and Health Sciences, Surgery
Abstract

Fecal microbiota transplant (FMT) is recommended for Clostridium difficile infection (CDI) treatment; however, use in solid organ transplantation (SOT) patients has theoretical safety concerns. This multicenter, retrospective study evaluated FMT safety, effectiveness, and risk factors for failure in SOT patients. Primary cure and overall cure were defined as resolution of diarrhea or negative C difficile stool test after a single FMT or after subsequent FMT(s) ± anti-CDI antibiotics, respectively. Ninety-four SOT patients underwent FMT, 78% for recurrent CDI and 22% for severe or fulminant CDI. FMT-related adverse events (AE) occurred in 22.3% of cases, mainly comprising self-limiting conditions including nausea, abdominal pain, and FMT-related diarrhea. Severe AEs occurred in 3.2% of cases, with no FMT-related bacteremia. After FMT, 25% of patients with underlying inflammatory bowel disease had worsening disease activity, while 14% of cytomegalovirus-seropositive patients had reactivation. At 3 months, primary cure was 58.7%, while overall cure was 91.3%. Predictors of failing a single FMT included inpatient status, severe and fulminant CDI, presence of pseudomembranous colitis, and use of non-CDI antibiotics at the time of FMT. These data suggest FMT is safe in SOT patients. However, repeated FMT(s) or additional antibiotics may be needed to optimize rates of cure with FMT.

Published
2019

34. Reply to Davido et al

Author

Khanna, Sahil, Tariq, Raseen, Tosh, Pritish K., Walker, Randall C., Razonable, Raymund R., and Pardi, Darrell S.

Published
2018

41. Predictors of gastrointestinal bleeding in patients following left ventricular assist device implantation: a systematic review and meta-analysis

Author

Gangwani, Manesh Kumar, primary, Aziz, Muhammad, additional, Nawras, Ali, additional, Priyanka, Fnu, additional, Ahmed, Zohaib, additional, Khan, Raja Samir, additional, Qamar, Mohammad Aadil, additional, Haroon, Fawad, additional, Aziz, Abeer, additional, Smith, Wade Lee, additional, Kirshan Ravi, Shri Jai, additional, Parikh, Vishal, additional, Alyousif, Zakaria, additional, Mahmood, Asif, additional, Tariq, Raseen, additional, Rai, Devesh, additional, and Aronow, Wilbert S, additional

Published
2022
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43. sj-docx-1-tag-10.1177_17562848231174293 – Supplemental material for Resolution rates in clinical trials for microbiota restoration for recurrent Clostridioides difficile infection: an updated systematic review and meta-analysis

Author

Tariq, Raseen, Pardi, Darrell S., and Khanna, Sahil

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tag-10.1177_17562848231174293 for Resolution rates in clinical trials for microbiota restoration for recurrent Clostridioides difficile infection: an updated systematic review and meta-analysis by Raseen Tariq, Darrell S. Pardi and Sahil Khanna in Therapeutic Advances in Gastroenterology

Published
2023
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