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117 results on '"Tarpley, Jason"'

1. Deep-ASPECTS: A Segmentation-Assisted Model for Stroke Severity Measurement

Author

Upadhyay, Ujjwal, Ranjan, Mukul, Golla, Satish, Tanamala, Swetha, Sreenivas, Preetham, Chilamkurthy, Sasank, Pandian, Jeyaraj, and Tarpley, Jason

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Statistics - Applications
Abstract

A stroke occurs when an artery in the brain ruptures and bleeds or when the blood supply to the brain is cut off. Blood and oxygen cannot reach the brain's tissues due to the rupture or obstruction resulting in tissue death. The Middle cerebral artery (MCA) is the largest cerebral artery and the most commonly damaged vessel in stroke. The quick onset of a focused neurological deficit caused by interruption of blood flow in the territory supplied by the MCA is known as an MCA stroke. Alberta stroke programme early CT score (ASPECTS) is used to estimate the extent of early ischemic changes in patients with MCA stroke. This study proposes a deep learning-based method to score the CT scan for ASPECTS. Our work has three highlights. First, we propose a novel method for medical image segmentation for stroke detection. Second, we show the effectiveness of AI solution for fully-automated ASPECT scoring with reduced diagnosis time for a given non-contrast CT (NCCT) Scan. Our algorithms show a dice similarity coefficient of 0.64 for the MCA anatomy segmentation and 0.72 for the infarcts segmentation. Lastly, we show that our model's performance is inline with inter-reader variability between radiologists.

Published
2022

2. Deep-ASPECTS: A Segmentation-Assisted Model for Stroke Severity Measurement

Author

Upadhyay, Ujjwal, Ranjan, Mukul, Golla, Satish, Tanamala, Swetha, Sreenivas, Preetham, Chilamkurthy, Sasank, Pandian, Jeyaraj, Tarpley, Jason, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Karlinsky, Leonid, editor, Michaeli, Tomer, editor, and Nishino, Ko, editor

Published
2023
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3. COVID-19 Impact on Acute Ischemic Stroke Treatment at 9 Comprehensive Stroke Centers across Los Angeles.

Author

Padrick, M, Sangha, Navdeep, Paletz, Laurie, Mirocha, James, Figueroa, Sonia, Manoukian, Vicki, Schlick, Konrad, Lyden, Patrick, Liebeskind, David, Chatfield, Fiona, Tarpley, Jason, Burgos, Adrian, Tenser, Matthew, Gaffney, Denise, Pech, Marco, Nazareth, Edward, Jackson, Robert, Kauffman, Helaine, Arnold, Lisa, Cox, Jennifer, Joyce, Treasure, Nakamura, Catrice, Fitzgerald, Darcie, Ogami, Kyle, Steiner, Nili, Wolber, Nicole, Robertson, Betty, Izzo, Rachel, Gorski, Stefanie, Manuel, Heather, Valdez, Krystal, Reyes, Liliana, Sharma, Latisha, and Song, Shlee

Subjects
COVID, Door-to-groin puncture time, Door-to-needle time, Ischemic stroke, Los Angeles, Reperfusion, Treatment, Brain Ischemia, COVID-19, Fibrinolytic Agents, Humans, Ischemic Stroke, Los Angeles, Retrospective Studies, SARS-CoV-2, Stroke, Thrombectomy, Thrombolytic Therapy, Time-to-Treatment, Treatment Outcome
Abstract

OBJECTIVE: To describe the impact of COVID-19 on acute cerebrovascular disease care across 9 comprehensive stroke centers throughout Los Angeles County (LAC). METHODS: Volume of emergency stroke code activations, patient characteristics, stroke severity, reperfusion rates, treatment times, and outcomes from February 1 to April 30, 2020, were compared against the same time period in 2019. Demographic data were provided by each participating institution. RESULTS: There was a 17.3% decrease in stroke code activations across LAC in 2020 compared to 2019 (1,786 vs. 2,159, respectively, χ2 goodness of fit test p < 0.0001) across 9 participating comprehensive stroke centers. Patients who did not receive any reperfusion therapy decreased by 16.6% in 2020 (1,527) compared to 2019 (1,832). Patients who received only intravenous thrombolytic (IVT) therapy decreased by 31.8% (107 vs. 157). Patients who received only mechanical thrombectomy (MT) increased by 3% (102 vs. 99). Patients who received both IVT and MT decreased by 31.8% (45 vs. 66). Recanalization treatment times in 2020 were comparable to 2019. CSCs serving a higher proportion of Latinx populations in the eastern parts of LAC experienced a higher incidence of MT in 2020 compared to 2019. Mild increase in stroke severity was seen in 2020 compared to 2019 (8.95 vs. 8.23, p = 0.046). A higher percentage of patients were discharged home in 2020 compared to 2019 (59.5 vs. 56.1%, p = 0.034), a lower percentage of patients were discharged to skilled nursing facility (16.1 vs. 20.7%, p = 0.0004), and a higher percentage of patients expired (8.6 vs. 6.3%, p = 0.008). CONCLUSION: LAC saw a decrease in overall stroke code activations in 2020 compared to 2019. Reperfusion treatment times remained comparable to prepandemic metrics. There has been an increase in severe stroke incidence and higher volume of thrombectomy treatments in Latinx communities within LAC during the pandemic of 2020. More patients were discharged home, less patients discharged to skilled nursing facilities, and more patients expired in 2020, compared to the same time frame in 2019.

Published
2021

4. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

Author

Demchuk, Andrew, Barber, Philip, Smith, Eric, Bal, Simerpreet, Subramaniam, Suresh, Peters, Steven, Couillard, Phillippe, Klein, Gary, Stys, Peter, Menon, Bijoy, Coutts, Shelagh, Almekhlafi, Mohammed, Hill, Michael, Goyal, Mayank, Wong, John, Mitha, Alim, Eesa, Muneer, Morrish, William, Alqatani, Saad, Kashani, Nima, Joshi, Manish, Zerna, Charlotte, Ospel, Johanna, Venkatesan, Prasanna, Teleg, Erika, Sitaram, Amith, Graham, Brett, Van Gaal, Stephen, Moussaddy, Aimen, Chakraborty, Debabrata, Maraj, Nicholas, Loockey, Andrew, Chen, Shuo, Singh, Ravinder, Alsultan, Abdulaziz, Asuncion, Ria, Tse, Dominic, Doshi, Darshan, Volny, Ondrej, Ojha, Piyush, Wadhwa, Ankur, Marko, Martha, Singh, Nishita, Wasyliw, Sanchea, Ryckborst, Karla, Kenney, Carol, Save, Supriya, Jambula, Anitha, Newcommon, Nancy, Hull, Gavin, Blackstock, Darcy, Kiszczak, Sharon, Zimmel, Leslie, Wright, Michelle, Jahraus, Cari, Andersen, Linda, Bohn, Shelly, Paul, Joseph, Zhang, Oiao, Doram, Craig, Lowerison, Mark, Hanley, Andrea, Campbell, Lori, Ure, Ashley, Taylor, Francis, Hul, Dominic, Wiebe, Samuel, Saluzzi, Marina, Blenkin, Nicole, Frayne, Richard, Buck, Brian, Butcher, Kenneth, Shuaib, Ashfaq, Jeerakathil, Tom, Jickling, Glen, Emery, Derek, Rempel, Jeremy, Owen, Richard, Ashforth, Robert, Yeo, Tom, Kotylak, Trevor, O'Kelly, Cian, Chow, Michael, Siddiqui, Muzaffer, Saqqur, Maher, D'Souza, Atlantic, Lloret, Mar, Butt, Asif, Nomani, Ali, Kalashyan, Hayrapet, Thirunavukkarasu, Sibi, Jabs, Juline, Fairall, Paige, Piquette, Lori, Phillips, Stephen, Green, A. Laine, Gubitz, Gordon, Heidenreich, Jens, Huynh, Thien, Shankar, Jai, Maloney, William, Vandorpe, Robert, Schmidt, Matthias, Pickett, Gwynedd, Weeks, Adrienne, Jarrett, Judith, MacDonald, Debbie, Arsenault, Joanna, Kinnear, Ruth, Mandzia, Jennifer, Mayich, Michael, Boulton, Melfort, Bullrich, Maria, Fridman, Sebastian, Kiwan, Ruba, Lee, Donald, Lownie, Stephen, Khaw, Alexander, Pandey, Sachin, Sharma, Manas, Sposato, Luciano, Wade, Kevin, Beauchamp, Beth, Lambourn, Lindsay, Amato-Marziali, Belinda, Poppe, Alexandre, Roy, Daniel, Daneault, Nicole, Deschaintre, Yan, Gioia, Laura, Jacquin, Grégory, Odier, Céline, Stapf, Christian, Iancu, Daniela, Raymond, Jean, Weill, Alain, Lapierre, Marlène, Jadil, Nadia, Jolteus, Judlène, Teitelbaum, Jeanne, Angle, Mark, Hannouche, Mathew, Badawy, Mohamed, Letourneau, Justin, Cortes, Maria, Linnell, Grant, Tampieri, Donateela, Vieira, Lucy, Legault, Catherine, Durcan, Liam, Moore, Angela, Cole, Erin, Magnussen, Claire, Salmon, Kristiana, Khalil, Salma, Desloges, Isabelle, Waxman, Lindsay, Abdon, Wynne, Lai, Sonia, Dowlatshahi, Dar, Shamy, Michel, Stotts, Grant, Blacquiere, Dylan, Lesiuk, Howard, Quateen, Aiman, Drake, Brian, Dewar, Brian, Daham, Zeinab, Kelly, Michael, Hunter, Gary, Peeling, Lissa, Whelan, Ruth, Garner, Aaron, Urroz, Lilian, Maley, Sharleen, Silver, Frank, Casaubon, Leanne, Pikula, Aleksandra, Del Campo, Martin, Schaafsma, Joanna, Jaigobin, Cheryl, Krings, Timo, Pereira, Vitor, Agid, Ronit, Farb, Richard, Kalman, Libby, Cayley, Anne, Williams, Janice, Stewart, Tim, Misquitta, Karen, Bharatha, Aditya, Selchen, Daniel, Marotta, Thomas, Sarma, Dipanka, Montanera, Walter, Spears, Juluan, Saposnik, Gustavo, Kostyrko, Pawel, Li, Yangmei, Parra-Farina, Carmen, Bengzon Diestro, Jose Danilo, Camden, Marie-Christine, Verreault, Steve, Mackey, Ariane, Audet, Marie-Eve, Milot, Geneviève, Lavoie, Pascale, Gariépy, Jean-Luc, Collard, Karine, Haché, Annette, Van Adel, Brian, Sahlas, Demetrios, Alshanbari, Ahmed, Baldwin, Josephine, Catanese, Luciana, Chen, Bing, De Sa Boasquevisque, Danielle, Deshmukh, Aviraj, Knapman, Jordan, Lamers, Shana, Larrazabal, Ramiro, MacMillan, Susan, Mai, Lauren, Mattia, Alicia, Nayar, Sumiti, Ng, Kuan, Oczkowski, Wieslaw, Perera, Kanjana, Shawawrah, Mays, Shoamanesh, Ashkan, Sobhi, Gita, Syed, Nabeel, Taher, Noran, Vandervelde, Cheyanne, Wang Pharm, Di, Field, Thalia, Teal, Philip, Benavente, Oscar, Wilson, Laura, Mann, Sharanpal, Yip, Samuel, Murphy, Colleen, Heran, Manraj, Rohr, Axel, Settecase, Fabio, Redekop, Gary, Haw, Charles, Maclean, Genoveva, Murray, Karina, Chiu, Rosalin, Flexman, Alana, Strecha, Eilidh, Gayton, Yolanda, Yip, Judy, Swartz, Richard, Boulos, Mark, Gladstone, David, Yu, Amy, Hopyan, Julia, Khosravani, Houman, Manosalva Alzate, Herbert, Southwell, Alisia, Kamra, Maneesha, Lopes, Kaitlyn, Kapoor, Arunima, da Costa, Leodante, Yang, Victor, Dyer, Erin, Shah, Ruchir, Knowles, Brenda, Nichols, Jennifer, Patterson, Jennifer, Cope, Krista, Dickerson, Lee, Barton, Katrina, Gray, Kimberly, Massengale, Ticey, Miller, Melanie, Simpson, Cindy, Walker, Sabrina, Tennyson-Yemm, Chlin, Devlin, Thomas, Frei, Donald, Bellon, Richard, Atchie, Benjamin, Kaminsky, Ian, Wilson, Duandelyn, Schraeder, Nicolle, Arias, Eric, Kodis, Lisa, Talley, Mark, Edinger, Alex, Talley, Tiffany, Dempsey, Ita, Williams, Laurie, Williams, Scott, Kupniewski, Sonny, Fasbinder, Brad, Snead, Joanna, Choe, Hana, Mackenzie, Larami, Weisman, Davi, Kozak, Osman, Shah, Qaisar, Gzesh, Dan, Kulandaivel, Kandan, Khoury, John, Klein, Brad, Bussinger, Patricia, Griffin, Lisa, dePalmo, Ashley, Oliva, Cynthia, Jadhav, Ashutosh, Jovin, Tudor, Kenmuir, Cynthia, Jankowitz, Brian, Gross, Bradley, Rocha, Marcelo, Starr, Matthew, Brown, Merritt, Hawkes, Christine, Shah, Kavit, Tememe, Danoushka, Walker, Gregory, Patel, Pratit, Klein, Bradley, Ziayee, Habibullah, Limaye, Kaustubh, Baxendell, Lisa, Gilchrist, Vicki, Feineigle, Patricia, Toseki Haibach, Kelsea, Van Every, Cathy, Desai, Shashyat, Zulfiqar, Maryam, Gibson, Linda, Barrett, Sean, Turkel-Parrella, David, Arcot, Karthikeyan, DiCrescento, Steven, Farkas, Jeffrey, Filipowski, Gregory, Frontera, Jennifer, Joset, Danielle, Liff, Jeremy, Scher, Erica, McDougall, Cameron, Kelly, Cheryl, Patel, Akshal, Monteith, Stephen, Starkman, Sidney, Atchaneeyasakul, Kunakorn, Burgos, Adrian, Chua, Janice Anne, Gaines, Nathan, Grunberg, Ileana, Guzy, Judy, Liu, Zuolu, Maluste, Neil, Ramirez, Lucas, Sharma, Latisha, Heck, Donald, Brown, Morry, McDonald, Colin, Calderon, Mateo, Hargis, Mitch, Roels, Christina, Emmady, Prabhu, Alvi, Talat, McTaggart, Ryan, Jayaraman, Mahesh, Cutting, Shawna, Smith, Wendy, Foley, Susan, Paolucci, Gino, Has, Richard, Quinn, Katie, Fuller, Lindsey, Brierley, Rebecca, Watkins, Christina, Demir, Nicole, Lopez, George, Vargas, Alejandro, Osteraas, Nicholas, Holtz, Becky, Sauvageau, Eric, Hanel, Ricardo, Aghaebrahim, Amin, Chmayssani, Mohamad, Naval, Neeraj, Day, Jason, Dellorso, Scott, Ludwig, Benjamin, Schemmel, Derek, Ebreo, Nancy, Bell, Karen, Lewis, Lanai, Delucia, Marjorie, Nogueira, Raul, Haussen, Diogo, Frankel, Michael, Bhatt, Nirav, Bianchi, Nicolas, Anderson, Aaron, Belagaje, Samir, Liberato, Bernardo, Rangaraju, Srikant, Al-Bayati, Alhamza, Grossberg, Jonathan, Craft, Leah, Schindler, Kiva, Schaad, Erin, Schultz, Meagan, Southerly, Lorretta, Doppelheuer, Shannon, Charlton, Jacquelyn, Faggard, Jason, Barbret, Zuzana, DukSoo Han, Ethan, Walters, Robin, Dolia, Jaydevsinh, El-Jamal, Sleiman, Eby, Brendan, Saleem, Yasir, Pearl, Harrison, Patel, Kishan, Rahman, Haseeb, Butt, Reema, English, Stephen, Puri, Ajit, Howk, Mary, Singh, Jasmeet, Massari, Francesco, DeMacedo Rodrigues, Katyucia, Kuhn, Anna, English, Joey, Barazangi, Nobl, Telischak, Nick, Kim, Warren, Ross, Josh, DeVole, Nata, Redford, Jessica, Ferreira, Milena, Ponting, Katie, Shen, Helen, Bedenk, Ann, Patel, Susila, Fernandess, Julia, Ke, Michael, Spokoyny, Ilanit, Gao, Billy, Tong, David, Chen, Charlene, Wong, Christine, Choe, Jessica, Martin, Coleman, Summers, Debbie, Boutwell, Christine, Olds, Karin, Crandall, Suzanne, Eatman, John, Akhtar, Naveed, Holloway, William, Halpin, Jared, Donegan, Brett, Schindler, Joseph, Hwang, David, Gilmore, Emily, Petersen, Nils, Sheth, Kevin, Brown, Stacy, Beekman, Rachel, George, Benjamin, Kaddouh, Firas, Falcone, Guido, Wira, Charles, Matouk, Charles, Loomis, Caitlin, Amin, Hardik, Stretz, Hans Christoph, Narula, Reshma, Jasne, Adam, Sansing, Lauren, Agarwal, Tijil, Jasak, Sara, Fontaine, Briana, King, Zachary, Kuohn, Lindsey, Orgass, Hailey, Leary, Megan, Nye, Joan, Halbert, Kelsey, Nystrom, Karin, Neuschatz, Kaile, Petrucci, Dawn, Coppola, Anna, Tarpley, Jason, Joyce, Treasure, Hou, Sam, Umekubo, Mark, Nakamura, Catrice, Ovando, Renee, Zuniga, Diana, Nien, Yih Lin, Basto, Fernando Mayor, Arch, Allison, Jong, Laura, Conrad, William, Abbott, Tara, Yao, Jay, Caganap, Scott, Jordan, John, Teitelbaum, George, Darflinger, Robert, Gupta, Rishi, Bain, Marianne, Budzik, Ronald, Czerniak, Jennifer, Groezinger, Katherine, Hicks II, William, Kaskar, Omran, Katz, Brian, Loochtan, Aaron, Pema, Peter, Rai, Vivek, Vora, Nirav, Brown, Amanda, Goodman, Diane, Danenbergs, Barb, Gossett, Monica, Bang, Oh Young, Chung, Jong-Won, Jeon, Pyoung, Kim, Keon Ha, Lim, Yun Jeong, Heo, Ji Hoe, Nam, Hyo Suk, Kim, Young Dae, Park, HyungJong, Hwang, In Gun, Ha, Wooseok, Choi, Jin Kyo, Jeong, Kyungsun, Rha, Joung-Ho, Park, Hee-Kwon, Yoon, Cindy, Kim, Bo-Kyung, Sohn, Sung-Il, Kim, Chang-hyun, Yoo, Joonsang, Hong, Jeong-Ho, Park, Hyungjong, Kim, Sohyeon, Choi, Moonkyung, Bae, Hyoeun, Lee, Jun Seok, Lee, Jae-Joon, Jun, Go-Eun, Jeon, Sujeong, Campbell, Bruce, Mitchell, Peter, Yassi, Nawaf, Davis, Stephen, Donnan, Geoffrey, Parsons, Mark, Yan, Bernard, Dowling, Richard, Bush, Steven, Wu, Teddy, Shah, Darshan, Zhao, Henry, Salvaris, Patrick, Alemseged, Fana, Ng, Felix, Williams, Cameron, Balabanski, Anna, Dos Santos, Angela, Ng, Jo-Lyn, McDonald, Amy, Jackson, David, Tsoleridis, Jessica, Pesavento, Lauren, Kleinig, Timothy John, Nurs, Roy Drew, Cranefield, Jennifer, Scroop, Rebecca, Cagi, Lavenia, Harvey, Jackson, Waters, Michael, Thornton, John, Brennan, Robert, O'Hare, Alan, Power, Sarah, Williams, David, Boyle, Karl, Moynihan, Barry, Liddy, Ann-Marie, Large, Margaret, Cullen, Ailbhe, Walsh, Roisin, Martin, Emma, Lynch, Julie, McElroy, Sinéad, Murphy, Seán, Coveney, Sarah, Deegan, Caroline, Horgan, Gillian, Kelly, Peter, Laffan, Aoife, Llamas-Osorio, Yudy, Lynch, Catherine, Mac Mahon, Peter, Marnane, Michael, McCabe, John, Burns, Paul, Tauro, Suzanne, Cuddy, Sarah, Rennie, Ian, Smyth, Graham, Flynn, Peter, Wiggam, Ivan, Kerr, Enda, Gordon, Patricia, Fearon, Patricia, Roberts, Geralt, Patterson, Cathy, Adams, Karen, Wells, Brian, McFarland, Margaret, Holmin, Staffan, Moreira, Tiago, Sjöstrand, Christina, Mazya, Michael, Almqvist, Håkan, Wahlgren, Nils, Steinberg, Anna, Cooray, Charith, Eriksson, Einar, Thorén, Magnus, Keselman, Boris, Ahmed, NIaz, Holmberg, Åke, Axelsson, Maria, Berglund, Annika, Thomalla, Götz, Golsari, Amir, Hoppe, Julia, Deb-Chatterji, Milani, Cheng, Bastian, Barrow, Ewgenia, Schlemm, Eckhard, Lettow, Iris, Jensen, Märit, Otto, Dagmar, Jaramillo, Kirsten, Appelbohm, Hannes, Fiehler, Jens, Bester, Maxim, Schönfeld, Michael, Brekenfeld, Caspar, Holst, Brigitte, Wortmann, Ginette, Koch, Friederike, Puetz, Volker, Gerber, Johannes, Abramyuk, Andrij, Kaiser, Daniel, Winzer, Simon, Prakapenia, Alexandra, Pallesen, Lars-Peder, Siepmann, Timo, Barlinn, Kristian, Haase, Kathrin, Sauer, Angela, Psychogios, Marios-Nikos, Liman, Jan, Brehm, Alex, Maus, Volker, Hollstein, Nicole, Reinke, Annika, Neitz, Gustav, Schnieder, Marlena, Schwarz, Margret, Ibrahim, Allam, Müller, Julia, Meister, Stefanie, Bäumle, Berit, Chapot, René, Pilgram-Pastor, Sara, Wallocha, Marta, Stauder, Michael, Celik, Ekin, Stracke, Paul, Müller, Nicole, Weber, Ralph, Velktamp, Roland, Nagel, Simon, Ringleb, Peter Arthur, Heyse, Miriam, Amiri, Hemasse, Mundiyanapurath, Sibu, Chen, Min, Bevrle, Elisabeth, Beck, Perdita, Möhlenbruch, Markus alfred, Tymianski, Michael, Potvin, Alphonse, Harris, Cameron, Wang, Chong, Adams, Corey, Mayor, Diana, Garman, Dave, Chau, Davis, Wu, Jane, Lunn, Janet, Heard, Kathy, Bermanis, Liat, Teyes, Lucy, Constant, Marc, Galsim, Maria, Helbin, Michael, Leroux, Michelle, Felix, Nicole, Bendre, Nilima, Cuthbert, Sandra, Brokx, Steve, Zhang, Yichuan, Lingham, Trudy, Kohli, Yatika, Salter, Michael, Liebeschuetz, Joseph, Hofmann, Frieder, Constant, John, Soeder, Tom, Snoke, Kara, Bologa, Monica, Stahl, Kimberly, Graziewicz, Maria, Hill, Michael D, Menon, Bijoy K, Nogueira, Raul G, McTaggart, Ryan A, Demchuk, Andrew M, Poppe, Alexandre Y, Buck, Brian H, Field, Thalia S, van Adel, Brian A, Swartz, Richard H, Shah, Ruchir A, Ospel, Johanna M, Almekhlafi, Mohammed A, Ryckborst, Karla J, Lowerison, Mark W, Garman, David, Cutting, Shawna M, Coutts, Shelagh B, Rempel, Jeremy L, Rohr, Axel CR, Sahlas, Demetrios J, Yu, Amy Y X, Devlin, Thomas G, Hanel, Ricardo A, Silver, Frank L, Campbell, Bruce C V, Mandzia, Jennifer L, Kleinig, Timothy J, Kelly, Michael E, Frei, Donald F, Tarpley, Jason W, McDougall, Cameron G, Puri, Ajit S, Phillips, Stephen J, Schindler, Joseph L, Budzik, Ronald F, Martin, Coleman O, Burns, Paul A, and Lopez, George A

Published
2020
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5. Thrombectomy With the pRESET vs Solitaire Stent Retrievers as First-Line Large Vessel Occlusion Stroke Treatment

Author

Nogueira, Raul G., primary, Lobsien, Donald, additional, Klisch, Joachim, additional, Pielenz, Daniel, additional, Lobsien, Elmar, additional, Sauvageau, Eric, additional, Aghaebrahim, Nima, additional, Möhlenbruch, Markus, additional, Vollherbst, Dominik, additional, Ulfert, Christian, additional, Bozorgchami, Hormozd, additional, Clark, Wayne, additional, Priest, Ryan, additional, Samaniego, Edgar A., additional, Ortega-Gutierrez, Santiago, additional, Ghannam, Malik, additional, Lopes, Demetrius, additional, Billingsley, Joshua, additional, Keigher, Kiffon, additional, Haussen, Diogo C., additional, Al-Bayati, Alhamza R., additional, Siddiqui, Adnan, additional, Levy, Elad, additional, Chen, Michael, additional, Munich, Stephan, additional, Schramm, Peter, additional, Boppel, Tobias, additional, Narayanan, Sandra, additional, Gross, Bradley A., additional, Roth, Christian, additional, Boeckh-Behrens, Tobias, additional, Hassan, Ameer, additional, Fifi, Johanna, additional, Budzik, Ron F., additional, Tarpley, Jason, additional, Starke, Robert M., additional, Raz, Eytan, additional, Brogan, Gary, additional, Liebeskind, David S., additional, and Hanel, Ricardo A., additional

Published
2024
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6. Infarct Evolution on MR-DWI After Thrombectomy in Acute Stroke Patients Randomized to Nerinetide or Placebo

Author

Fladt, Joachim, primary, Guo, Jen, additional, Specht, Jacinta L., additional, Wang, Meng, additional, Chan, Leona L., additional, Mctaggart, Ryan, additional, Buck, Brian H., additional, Aviv, Richard, additional, Swartz, Richard H., additional, Field, Thalia S., additional, Tarpley, Jason, additional, Shah, Ruchir, additional, Goyal, Mayank, additional, Tymianski, Michael, additional, Hill, Michael D., additional, Demchuk, Andrew, additional, d'Esterre, Christopher, additional, and Barber, Philip, additional

Published
2024
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7. Increased Access to and Use of Endovascular Therapy Following Implementation of a 2-Tiered Regional Stroke System

Author

Bosson, Nichole, Gausche-Hill, Marianne, Saver, Jeffrey L, Sanossian, Nerses, Tadeo, Richard, Clare, Christine, Perez, Lorrie, Williams, Michelle, Rasnake, Sara, Nguyen, Phuong-Lan, Taqui, Asif, Evans-Cobb, Cheryl, Gaffney, Denise, Duckwiler, Gary, Ganguly, Gautam, Sung, Gene, Kaufman, Helaine, Rokos, Ivan, Tarpley, Jason, Anotado, Jennifer, Nour, May, Jocson, Michelle, Ramezan, Nima, Patel, Nirav, Lyden, Patrick, Jahan, Reza, Burrus, Tamika, Mack, William, and Ajani, Zahra

Published
2020
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8. Abstract WP143: Use Of CTP For Evaluation Of EVT Candidates In The Early Time Window (<6 Hours From Lkwt) Does Not Delay EVT T And Use Of CTP Beyond 6 Hours Improves Speed Of EVT

Author

Marginean, Horia, primary, Corless, Leslie, additional, Loh, Yince, additional, Bavarsadshahripour, Reza, additional, Windisch, Thomas, additional, Guerrero, Adrieanne, additional, Lopez, George, additional, Hancock, Sarah, additional, and Tarpley, Jason W, additional

Published
2023
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9. Abstract TP14: Does Atrial Fibrillation (Afib) Impact The Rate Of 90 Days Modified Rankin Scale (mRS) In Patients Who Received Intravenous Thrombolytic (IVT) Before Endovascular Treatment (EVT)?results From A Large Health System In Six Western States Of The United States

Author

Bavarsad Shahripour, Reza, primary, Marginean, Horia, additional, Corless, Leslie, additional, Lowenkopf, Ted J, additional, Lesko, Alexandra C, additional, Guerrero, Adrieanne, additional, Singh, Tarvinder, additional, Loh, Yince, additional, Pirastehfar, Mohsen, additional, and Tarpley, Jason W, additional

Published
2023
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10. Abstract WP161: Does History Of Atrial Fibrillation (Afib) Impact TICI Scores In Acute Ischemic Stroke Patients Receiving Endovascular Treatment With Or Without Iv Thrombolytics? Results From A Large Health System In Six Western States Of The United States

Author

Bavarsad Shahripour, Reza, primary, Marginean, Horia, additional, Corless, Leslie, additional, Arnold, Lisa, additional, Guerrero, Adrieanne, additional, Lowenkopf, Ted J, additional, Singh, Tarvinder, additional, Lesko, Alexandra C, additional, Loh, Yince, additional, Pirastehfar, Mohsen, additional, and Tarpley, Jason W, additional

Published
2023
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11. Abstract 24: Primary Results Of The Preset For Occlusive Stroke Treatment (prost) Randomized Clinical Trial

Author

Nogueira, Raul G, primary, Hanel, Ricardo, additional, Klisch, Joachim, additional, Moehlenbruch, Markus, additional, Bozorgchami, Hormozd, additional, Samaniego, Edgar A, additional, Liebeskind, David S, additional, Lobsien, Donald, additional, Pielenz, Daniel, additional, Sauvageau, Eric, additional, Aghaebrahim, Amin N, additional, Clark, Wayne M, additional, Priest, Ryan, additional, Ortega-Gutierrez, Santiago, additional, Lopes, Demetrius, additional, Billingsley, Joshua, additional, Haussen, Diogo C, additional, Al-Bayati, Alhamza R, additional, Siddiqui, Adnan H, additional, Chen, Michael, additional, Schramm, Peter, additional, Narayanan, Sandra, additional, Roth, Christian, additional, Boeckh-Behrens, Tobias, additional, Hassan, Ameer E, additional, Fifi, Johanna T, additional, Budzik, Ronald, additional, Tarpley, Jason W, additional, Starke, Robert, additional, and Raz, Eytan, additional

Published
2023
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13. Abstract TP109: The Impact Of Atrial Fibrillation (Afib) On The Discharge Disposition In Patients Who Received Acute Stroke Intervention Therapies? Results From A Large Health System In Six Western States Of The United States

Author

Bavarsad Shahripour, Reza, primary, Marginean, Horia, additional, Corless, Leslie, additional, Singh, Tarvinder, additional, Loh, Yince, additional, Lowenkopf, Ted J, additional, Lesko, Alexandra C, additional, Guerrero, Adrieanne, additional, Pirastehfar, Mohsen, additional, and Tarpley, Jason W, additional

Published
2023
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14. Intraarterial Treatment Versus No Intraarterial Treatment within 24 Hours in Patients with Ischaemic Stroke and Large Infarct on Noncontrast CT (TESLA): A Multicentre, Open-Label, Blinded-Endpoint, Randomised, Controlled, Phase 3 Trial

Author

Yoo, Albert J., primary, Zaidat, Osama O., additional, Al Kasab, Sami, additional, Sheth, Sunil A., additional, Rai, Ansaar T., additional, Ortega-Gutierrez, Santiago, additional, Given, Curtis A., additional, Zaidi, Syed F., additional, Grandhi, Ramesh, additional, Cuellar, Hugo, additional, Mokin, Maxim, additional, Katz, Jeffrey M., additional, Alshekhlee, Amer, additional, Taqi, Muhammad A., additional, Ansari, Sameer A., additional, Siddiqui, Adnan H., additional, Barazangi, Nobl, additional, English, Joey D., additional, Maud, Alberto, additional, Kirmani, Jawad, additional, Gupta, Rishi, additional, Yavagal, Dileep, additional, Tarpley, Jason, additional, Pandya, Dhruvil J., additional, Cress, Marshall C., additional, Dharmadhikari, Sushrut, additional, Asif, Kaiz, additional, Kass-Hout, Tareq, additional, Puri, Ajit S., additional, Janjua, Nazli, additional, Majjhoo, Aniel, additional, Badruddin, Aamir, additional, Edgell, Randall C., additional, Khatri, Rakesh, additional, Morgan, Larry, additional, Razak, Anmar, additional, Zha, Alicia, additional, Khandelwal, Priyank, additional, Mueller-Kronast, Nils H., additional, Rivet, Dennis J., additional, Wolfe, Thomas, additional, Snelling, Brian, additional, Sultan-Qurraie, Ali, additional, Lin, Shao-Pow, additional, Khangura, Rajkamal, additional, Spiotta, Alejandro, additional, Bhuva, Parita, additional, Salazar-Marioni, Sergio, additional, Lin, Eugene, additional, Tarabishy, Abdul R., additional, Samaniego, Edgar A., additional, Kolikonda, Murali, additional, Jumaa, Mouhammad A., additional, Reddy, Vivek K., additional, Sharma, Pankaj, additional, Berkhemer, Olvert A., additional, van Doormaal, Pieter Jan, additional, van Es, Adriaan C.G.M, additional, van Zwam, Wim H., additional, Emmer, Bart J., additional, Beenen, Ludo, additional, Buderer, Nancy, additional, Detry, Michelle A., additional, Bosse, Anna, additional, Graves, Todd L., additional, Saunders, Christina, additional, Elijovich, Lucas, additional, Jadhav, Ashutosh, additional, Brown, Scott, additional, Nguyen, Thanh N., additional, Gress, Daryl, additional, Patterson, Mary, additional, Slight, Hannah, additional, Below, Kristine, additional, Dippel, Diederik W.J., additional, Smith, Wade S., additional, and Investigators, TESLA, additional

Published
2023
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16. Transcranial Doppler After Endovascular Treatment to Evaluate Collateral Status and Outcomes in Patients With Large‐Vessel Occlusion

Author

Bavarsad Shahripour, Reza, primary, Azarpazhooh, Mahmoud Reza, additional, Akhuanzada, Humayon, additional, Tarpley, Jason W., additional, Borhani‐Haghighi, Afshin, additional, Agrawal, Kunal, additional, Modir, Royya, additional, Meyer, Brett, additional, Hemmen, Thomas M, additional, and Meyer, Dawn, additional

Published
2022
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18. Abstract WP161: Patients With Lower Stroke Scales Take Longer To Treat With Endovascular Thrombectomy Because Of A Longer Time To Identify Their Lvo Not Because Of Longer Procedural Time: Time To Identify And Triage An Lvo Is More Important Determinant Of Treatment Speed Than Procedural Time

Author

Stuchiner, Tamela L, primary, Baraban, Elizabeth, additional, Martin, Neil, additional, Kelly, Dan, additional, Teitelbaum, George P, additional, Ovando, Renee, additional, and Tarpley, Jason W, additional

Published
2022
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19. Abstract WMP90: Patients With MEVO Take Longer To Treat With Endovascular Thrombectomy Because Of A Longer Time To Identify Candidates For Therapy (door To Groin Puncture) As Well As Longer Procedural Times (groin Puncture To First Thrombectomy Pass)

Author

Baraban, Elizabeth, primary, Stuchiner, Tamela L, additional, Martin, Neil, additional, Bavarsad Shahripour, Reza, additional, Kelly, Daniel, additional, Teitelbaum, George P, additional, Ovando, Renee, additional, and Tarpley, Jason W, additional

Published
2022
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21. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

Author

Hill, Michael D, primary, Goyal, Mayank, additional, Menon, Bijoy K, additional, Nogueira, Raul G, additional, McTaggart, Ryan A, additional, Demchuk, Andrew M, additional, Poppe, Alexandre Y, additional, Buck, Brian H, additional, Field, Thalia S, additional, Dowlatshahi, Dar, additional, van Adel, Brian A, additional, Swartz, Richard H, additional, Shah, Ruchir A, additional, Sauvageau, Eric, additional, Zerna, Charlotte, additional, Ospel, Johanna M, additional, Joshi, Manish, additional, Almekhlafi, Mohammed A, additional, Ryckborst, Karla J, additional, Lowerison, Mark W, additional, Heard, Kathy, additional, Garman, David, additional, Haussen, Diogo, additional, Cutting, Shawna M, additional, Coutts, Shelagh B, additional, Roy, Daniel, additional, Rempel, Jeremy L, additional, Rohr, Axel CR, additional, Iancu, Daniela, additional, Sahlas, Demetrios J, additional, Yu, Amy Y X, additional, Devlin, Thomas G, additional, Hanel, Ricardo A, additional, Puetz, Volker, additional, Silver, Frank L, additional, Campbell, Bruce C V, additional, Chapot, René, additional, Teitelbaum, Jeanne, additional, Mandzia, Jennifer L, additional, Kleinig, Timothy J, additional, Turkel-Parrella, David, additional, Heck, Donald, additional, Kelly, Michael E, additional, Bharatha, Aditya, additional, Bang, Oh Young, additional, Jadhav, Ashutosh, additional, Gupta, Rishi, additional, Frei, Donald F, additional, Tarpley, Jason W, additional, McDougall, Cameron G, additional, Holmin, Staffan, additional, Rha, Joung-Ho, additional, Puri, Ajit S, additional, Camden, Marie-Christine, additional, Thomalla, Götz, additional, Choe, Hana, additional, Phillips, Stephen J, additional, Schindler, Joseph L, additional, Thornton, John, additional, Nagel, Simon, additional, Heo, Ji Hoe, additional, Sohn, Sung-Il, additional, Psychogios, Marios-Nikos, additional, Budzik, Ronald F, additional, Starkman, Sidney, additional, Martin, Coleman O, additional, Burns, Paul A, additional, Murphy, Seán, additional, Lopez, George A, additional, English, Joey, additional, Tymianski, Michael, additional, Demchuk, Andrew, additional, Barber, Philip, additional, Smith, Eric, additional, Bal, Simerpreet, additional, Subramaniam, Suresh, additional, Peters, Steven, additional, Couillard, Phillippe, additional, Klein, Gary, additional, Stys, Peter, additional, Menon, Bijoy, additional, Coutts, Shelagh, additional, Almekhlafi, Mohammed, additional, Hill, Michael, additional, Wong, John, additional, Mitha, Alim, additional, Eesa, Muneer, additional, Morrish, William, additional, Alqatani, Saad, additional, Kashani, Nima, additional, Ospel, Johanna, additional, Venkatesan, Prasanna, additional, Teleg, Erika, additional, Sitaram, Amith, additional, Graham, Brett, additional, Van Gaal, Stephen, additional, Moussaddy, Aimen, additional, Chakraborty, Debabrata, additional, Maraj, Nicholas, additional, Loockey, Andrew, additional, Chen, Shuo, additional, Singh, Ravinder, additional, Alsultan, Abdulaziz, additional, Asuncion, Ria, additional, Tse, Dominic, additional, Doshi, Darshan, additional, Volny, Ondrej, additional, Ojha, Piyush, additional, Wadhwa, Ankur, additional, Marko, Martha, additional, Singh, Nishita, additional, Wasyliw, Sanchea, additional, Ryckborst, Karla, additional, Kenney, Carol, additional, Save, Supriya, additional, Jambula, Anitha, additional, Newcommon, Nancy, additional, Hull, Gavin, additional, Blackstock, Darcy, additional, Kiszczak, Sharon, additional, Zimmel, Leslie, additional, Wright, Michelle, additional, Jahraus, Cari, additional, Andersen, Linda, additional, Bohn, Shelly, additional, Paul, Joseph, additional, Zhang, Oiao, additional, Doram, Craig, additional, Lowerison, Mark, additional, Hanley, Andrea, additional, Campbell, Lori, additional, Ure, Ashley, additional, Taylor, Francis, additional, Hul, Dominic, additional, Wiebe, Samuel, additional, Saluzzi, Marina, additional, Blenkin, Nicole, additional, Frayne, Richard, additional, Buck, Brian, additional, Butcher, Kenneth, additional, Shuaib, Ashfaq, additional, Jeerakathil, Tom, additional, Jickling, Glen, additional, Emery, Derek, additional, Rempel, Jeremy, additional, Owen, Richard, additional, Ashforth, Robert, additional, Yeo, Tom, additional, Kotylak, Trevor, additional, O'Kelly, Cian, additional, Chow, Michael, additional, Siddiqui, Muzaffer, additional, Saqqur, Maher, additional, D'Souza, Atlantic, additional, Lloret, Mar, additional, Butt, Asif, additional, Nomani, Ali, additional, Kalashyan, Hayrapet, additional, Thirunavukkarasu, Sibi, additional, Jabs, Juline, additional, Fairall, Paige, additional, Piquette, Lori, additional, Phillips, Stephen, additional, Green, A. Laine, additional, Gubitz, Gordon, additional, Heidenreich, Jens, additional, Huynh, Thien, additional, Shankar, Jai, additional, Maloney, William, additional, Vandorpe, Robert, additional, Schmidt, Matthias, additional, Pickett, Gwynedd, additional, Weeks, Adrienne, additional, Jarrett, Judith, additional, MacDonald, Debbie, additional, Arsenault, Joanna, additional, Kinnear, Ruth, additional, Mandzia, Jennifer, additional, Mayich, Michael, additional, Boulton, Melfort, additional, Bullrich, Maria, additional, Fridman, Sebastian, additional, Kiwan, Ruba, additional, Lee, Donald, additional, Lownie, Stephen, additional, Khaw, Alexander, additional, Pandey, Sachin, additional, Sharma, Manas, additional, Sposato, Luciano, additional, Wade, Kevin, additional, Beauchamp, Beth, additional, Lambourn, Lindsay, additional, Amato-Marziali, Belinda, additional, Poppe, Alexandre, additional, Daneault, Nicole, additional, Deschaintre, Yan, additional, Gioia, Laura, additional, Jacquin, Grégory, additional, Odier, Céline, additional, Stapf, Christian, additional, Raymond, Jean, additional, Weill, Alain, additional, Lapierre, Marlène, additional, Jadil, Nadia, additional, Jolteus, Judlène, additional, Angle, Mark, additional, Hannouche, Mathew, additional, Badawy, Mohamed, additional, Letourneau, Justin, additional, Cortes, Maria, additional, Linnell, Grant, additional, Tampieri, Donateela, additional, Vieira, Lucy, additional, Legault, Catherine, additional, Durcan, Liam, additional, Moore, Angela, additional, Cole, Erin, additional, Magnussen, Claire, additional, Salmon, Kristiana, additional, Khalil, Salma, additional, Desloges, Isabelle, additional, Waxman, Lindsay, additional, Abdon, Wynne, additional, Lai, Sonia, additional, Shamy, Michel, additional, Stotts, Grant, additional, Blacquiere, Dylan, additional, Lesiuk, Howard, additional, Quateen, Aiman, additional, Drake, Brian, additional, Dewar, Brian, additional, Daham, Zeinab, additional, Kelly, Michael, additional, Hunter, Gary, additional, Peeling, Lissa, additional, Whelan, Ruth, additional, Garner, Aaron, additional, Urroz, Lilian, additional, Maley, Sharleen, additional, Silver, Frank, additional, Casaubon, Leanne, additional, Pikula, Aleksandra, additional, Del Campo, Martin, additional, Schaafsma, Joanna, additional, Jaigobin, Cheryl, additional, Krings, Timo, additional, Pereira, Vitor, additional, Agid, Ronit, additional, Farb, Richard, additional, Kalman, Libby, additional, Cayley, Anne, additional, Williams, Janice, additional, Stewart, Tim, additional, Misquitta, Karen, additional, Selchen, Daniel, additional, Marotta, Thomas, additional, Sarma, Dipanka, additional, Montanera, Walter, additional, Spears, Juluan, additional, Saposnik, Gustavo, additional, Kostyrko, Pawel, additional, Li, Yangmei, additional, Parra-Farina, Carmen, additional, Bengzon Diestro, Jose Danilo, additional, Verreault, Steve, additional, Mackey, Ariane, additional, Audet, Marie-Eve, additional, Milot, Geneviève, additional, Lavoie, Pascale, additional, Gariépy, Jean-Luc, additional, Collard, Karine, additional, Haché, Annette, additional, Van Adel, Brian, additional, Sahlas, Demetrios, additional, Alshanbari, Ahmed, additional, Baldwin, Josephine, additional, Catanese, Luciana, additional, Chen, Bing, additional, De Sa Boasquevisque, Danielle, additional, Deshmukh, Aviraj, additional, Knapman, Jordan, additional, Lamers, Shana, additional, Larrazabal, Ramiro, additional, MacMillan, Susan, additional, Mai, Lauren, additional, Mattia, Alicia, additional, Nayar, Sumiti, additional, Ng, Kuan, additional, Oczkowski, Wieslaw, additional, Perera, Kanjana, additional, Shawawrah, Mays, additional, Shoamanesh, Ashkan, additional, Sobhi, Gita, additional, Syed, Nabeel, additional, Taher, Noran, additional, Vandervelde, Cheyanne, additional, Wang Pharm, Di, additional, Field, Thalia, additional, Teal, Philip, additional, Benavente, Oscar, additional, Wilson, Laura, additional, Mann, Sharanpal, additional, Yip, Samuel, additional, Murphy, Colleen, additional, Heran, Manraj, additional, Rohr, Axel, additional, Settecase, Fabio, additional, Redekop, Gary, additional, Haw, Charles, additional, Maclean, Genoveva, additional, Murray, Karina, additional, Chiu, Rosalin, additional, Flexman, Alana, additional, Strecha, Eilidh, additional, Gayton, Yolanda, additional, Yip, Judy, additional, Swartz, Richard, additional, Boulos, Mark, additional, Gladstone, David, additional, Yu, Amy, additional, Hopyan, Julia, additional, Khosravani, Houman, additional, Manosalva Alzate, Herbert, additional, Southwell, Alisia, additional, Kamra, Maneesha, additional, Lopes, Kaitlyn, additional, Kapoor, Arunima, additional, da Costa, Leodante, additional, Yang, Victor, additional, Dyer, Erin, additional, Shah, Ruchir, additional, Knowles, Brenda, additional, Nichols, Jennifer, additional, Patterson, Jennifer, additional, Cope, Krista, additional, Dickerson, Lee, additional, Barton, Katrina, additional, Gray, Kimberly, additional, Massengale, Ticey, additional, Miller, Melanie, additional, Simpson, Cindy, additional, Walker, Sabrina, additional, Tennyson-Yemm, Chlin, additional, Devlin, Thomas, additional, Frei, Donald, additional, Bellon, Richard, additional, Atchie, Benjamin, additional, Kaminsky, Ian, additional, Wilson, Duandelyn, additional, Schraeder, Nicolle, additional, Arias, Eric, additional, Kodis, Lisa, additional, Talley, Mark, additional, Edinger, Alex, additional, Talley, Tiffany, additional, Dempsey, Ita, additional, Williams, Laurie, additional, Williams, Scott, additional, Kupniewski, Sonny, additional, Fasbinder, Brad, additional, Snead, Joanna, additional, Mackenzie, Larami, additional, Weisman, Davi, additional, Kozak, Osman, additional, Shah, Qaisar, additional, Gzesh, Dan, additional, Kulandaivel, Kandan, additional, Khoury, John, additional, Klein, Brad, additional, Bussinger, Patricia, additional, Griffin, Lisa, additional, dePalmo, Ashley, additional, Oliva, Cynthia, additional, Jovin, Tudor, additional, Kenmuir, Cynthia, additional, Jankowitz, Brian, additional, Gross, Bradley, additional, Rocha, Marcelo, additional, Starr, Matthew, additional, Brown, Merritt, additional, Hawkes, Christine, additional, Shah, Kavit, additional, Tememe, Danoushka, additional, Walker, Gregory, additional, Patel, Pratit, additional, Klein, Bradley, additional, Ziayee, Habibullah, additional, Limaye, Kaustubh, additional, Baxendell, Lisa, additional, Gilchrist, Vicki, additional, Feineigle, Patricia, additional, Toseki Haibach, Kelsea, additional, Van Every, Cathy, additional, Desai, Shashyat, additional, Zulfiqar, Maryam, additional, Gibson, Linda, additional, Barrett, Sean, additional, Arcot, Karthikeyan, additional, DiCrescento, Steven, additional, Farkas, Jeffrey, additional, Filipowski, Gregory, additional, Frontera, Jennifer, additional, Joset, Danielle, additional, Liff, Jeremy, additional, Scher, Erica, additional, McDougall, Cameron, additional, Kelly, Cheryl, additional, Patel, Akshal, additional, Monteith, Stephen, additional, Atchaneeyasakul, Kunakorn, additional, Burgos, Adrian, additional, Chua, Janice Anne, additional, Gaines, Nathan, additional, Grunberg, Ileana, additional, Guzy, Judy, additional, Liu, Zuolu, additional, Maluste, Neil, additional, Ramirez, Lucas, additional, Sharma, Latisha, additional, Brown, Morry, additional, McDonald, Colin, additional, Calderon, Mateo, additional, Hargis, Mitch, additional, Roels, Christina, additional, Emmady, Prabhu, additional, Alvi, Talat, additional, McTaggart, Ryan, additional, Jayaraman, Mahesh, additional, Cutting, Shawna, additional, Smith, Wendy, additional, Foley, Susan, additional, Paolucci, Gino, additional, Has, Richard, additional, Quinn, Katie, additional, Fuller, Lindsey, additional, Brierley, Rebecca, additional, Watkins, Christina, additional, Demir, Nicole, additional, Lopez, George, additional, Vargas, Alejandro, additional, Osteraas, Nicholas, additional, Holtz, Becky, additional, Hanel, Ricardo, additional, Aghaebrahim, Amin, additional, Chmayssani, Mohamad, additional, Naval, Neeraj, additional, Day, Jason, additional, Dellorso, Scott, additional, Ludwig, Benjamin, additional, Schemmel, Derek, additional, Ebreo, Nancy, additional, Bell, Karen, additional, Lewis, Lanai, additional, Delucia, Marjorie, additional, Nogueira, Raul, additional, Frankel, Michael, additional, Bhatt, Nirav, additional, Bianchi, Nicolas, additional, Anderson, Aaron, additional, Belagaje, Samir, additional, Liberato, Bernardo, additional, Rangaraju, Srikant, additional, Al-Bayati, Alhamza, additional, Grossberg, Jonathan, additional, Craft, Leah, additional, Schindler, Kiva, additional, Schaad, Erin, additional, Schultz, Meagan, additional, Southerly, Lorretta, additional, Doppelheuer, Shannon, additional, Charlton, Jacquelyn, additional, Faggard, Jason, additional, Barbret, Zuzana, additional, DukSoo Han, Ethan, additional, Walters, Robin, additional, Dolia, Jaydevsinh, additional, El-Jamal, Sleiman, additional, Eby, Brendan, additional, Saleem, Yasir, additional, Pearl, Harrison, additional, Patel, Kishan, additional, Rahman, Haseeb, additional, Butt, Reema, additional, English, Stephen, additional, Puri, Ajit, additional, Howk, Mary, additional, Singh, Jasmeet, additional, Massari, Francesco, additional, DeMacedo Rodrigues, Katyucia, additional, Kuhn, Anna, additional, Barazangi, Nobl, additional, Telischak, Nick, additional, Kim, Warren, additional, Ross, Josh, additional, DeVole, Nata, additional, Redford, Jessica, additional, Ferreira, Milena, additional, Ponting, Katie, additional, Shen, Helen, additional, Bedenk, Ann, additional, Patel, Susila, additional, Fernandess, Julia, additional, Ke, Michael, additional, Spokoyny, Ilanit, additional, Gao, Billy, additional, Tong, David, additional, Chen, Charlene, additional, Wong, Christine, additional, Choe, Jessica, additional, Martin, Coleman, additional, Summers, Debbie, additional, Boutwell, Christine, additional, Olds, Karin, additional, Crandall, Suzanne, additional, Eatman, John, additional, Akhtar, Naveed, additional, Holloway, William, additional, Halpin, Jared, additional, Donegan, Brett, additional, Schindler, Joseph, additional, Hwang, David, additional, Gilmore, Emily, additional, Petersen, Nils, additional, Sheth, Kevin, additional, Brown, Stacy, additional, Beekman, Rachel, additional, George, Benjamin, additional, Kaddouh, Firas, additional, Falcone, Guido, additional, Wira, Charles, additional, Matouk, Charles, additional, Loomis, Caitlin, additional, Amin, Hardik, additional, Stretz, Hans Christoph, additional, Narula, Reshma, additional, Jasne, Adam, additional, Sansing, Lauren, additional, Agarwal, Tijil, additional, Jasak, Sara, additional, Fontaine, Briana, additional, King, Zachary, additional, Kuohn, Lindsey, additional, Orgass, Hailey, additional, Leary, Megan, additional, Nye, Joan, additional, Halbert, Kelsey, additional, Nystrom, Karin, additional, Neuschatz, Kaile, additional, Petrucci, Dawn, additional, Coppola, Anna, additional, Tarpley, Jason, additional, Joyce, Treasure, additional, Hou, Sam, additional, Umekubo, Mark, additional, Nakamura, Catrice, additional, Ovando, Renee, additional, Zuniga, Diana, additional, Nien, Yih Lin, additional, Basto, Fernando Mayor, additional, Arch, Allison, additional, Jong, Laura, additional, Conrad, William, additional, Abbott, Tara, additional, Yao, Jay, additional, Caganap, Scott, additional, Jordan, John, additional, Teitelbaum, George, additional, Darflinger, Robert, additional, Bain, Marianne, additional, Budzik, Ronald, additional, Czerniak, Jennifer, additional, Groezinger, Katherine, additional, Hicks II, William, additional, Kaskar, Omran, additional, Katz, Brian, additional, Loochtan, Aaron, additional, Pema, Peter, additional, Rai, Vivek, additional, Vora, Nirav, additional, Brown, Amanda, additional, Goodman, Diane, additional, Danenbergs, Barb, additional, Gossett, Monica, additional, Chung, Jong-Won, additional, Jeon, Pyoung, additional, Kim, Keon Ha, additional, Lim, Yun Jeong, additional, Nam, Hyo Suk, additional, Kim, Young Dae, additional, Park, HyungJong, additional, Hwang, In Gun, additional, Ha, Wooseok, additional, Choi, Jin Kyo, additional, Jeong, Kyungsun, additional, Park, Hee-Kwon, additional, Yoon, Cindy, additional, Kim, Bo-Kyung, additional, Kim, Chang-hyun, additional, Yoo, Joonsang, additional, Hong, Jeong-Ho, additional, Park, Hyungjong, additional, Kim, Sohyeon, additional, Choi, Moonkyung, additional, Bae, Hyoeun, additional, Lee, Jun Seok, additional, Lee, Jae-Joon, additional, Jun, Go-Eun, additional, Jeon, Sujeong, additional, Campbell, Bruce, additional, Mitchell, Peter, additional, Yassi, Nawaf, additional, Davis, Stephen, additional, Donnan, Geoffrey, additional, Parsons, Mark, additional, Yan, Bernard, additional, Dowling, Richard, additional, Bush, Steven, additional, Wu, Teddy, additional, Shah, Darshan, additional, Zhao, Henry, additional, Salvaris, Patrick, additional, Alemseged, Fana, additional, Ng, Felix, additional, Williams, Cameron, additional, Balabanski, Anna, additional, Dos Santos, Angela, additional, Ng, Jo-Lyn, additional, McDonald, Amy, additional, Jackson, David, additional, Tsoleridis, Jessica, additional, Pesavento, Lauren, additional, Kleinig, Timothy John, additional, Nurs, Roy Drew, additional, Cranefield, Jennifer, additional, Scroop, Rebecca, additional, Cagi, Lavenia, additional, Harvey, Jackson, additional, Waters, Michael, additional, Brennan, Robert, additional, O'Hare, Alan, additional, Power, Sarah, additional, Williams, David, additional, Boyle, Karl, additional, Moynihan, Barry, additional, Liddy, Ann-Marie, additional, Large, Margaret, additional, Cullen, Ailbhe, additional, Walsh, Roisin, additional, Martin, Emma, additional, Lynch, Julie, additional, McElroy, Sinéad, additional, Coveney, Sarah, additional, Deegan, Caroline, additional, Horgan, Gillian, additional, Kelly, Peter, additional, Laffan, Aoife, additional, Llamas-Osorio, Yudy, additional, Lynch, Catherine, additional, Mac Mahon, Peter, additional, Marnane, Michael, additional, McCabe, John, additional, Burns, Paul, additional, Tauro, Suzanne, additional, Cuddy, Sarah, additional, Rennie, Ian, additional, Smyth, Graham, additional, Flynn, Peter, additional, Wiggam, Ivan, additional, Kerr, Enda, additional, Gordon, Patricia, additional, Fearon, Patricia, additional, Roberts, Geralt, additional, Patterson, Cathy, additional, Adams, Karen, additional, Wells, Brian, additional, McFarland, Margaret, additional, Moreira, Tiago, additional, Sjöstrand, Christina, additional, Mazya, Michael, additional, Almqvist, Håkan, additional, Wahlgren, Nils, additional, Steinberg, Anna, additional, Cooray, Charith, additional, Eriksson, Einar, additional, Thorén, Magnus, additional, Keselman, Boris, additional, Ahmed, NIaz, additional, Holmberg, Åke, additional, Axelsson, Maria, additional, Berglund, Annika, additional, Golsari, Amir, additional, Hoppe, Julia, additional, Deb-Chatterji, Milani, additional, Cheng, Bastian, additional, Barrow, Ewgenia, additional, Schlemm, Eckhard, additional, Lettow, Iris, additional, Jensen, Märit, additional, Otto, Dagmar, additional, Jaramillo, Kirsten, additional, Appelbohm, Hannes, additional, Fiehler, Jens, additional, Bester, Maxim, additional, Schönfeld, Michael, additional, Brekenfeld, Caspar, additional, Holst, Brigitte, additional, Wortmann, Ginette, additional, Koch, Friederike, additional, Gerber, Johannes, additional, Abramyuk, Andrij, additional, Kaiser, Daniel, additional, Winzer, Simon, additional, Prakapenia, Alexandra, additional, Pallesen, Lars-Peder, additional, Siepmann, Timo, additional, Barlinn, Kristian, additional, Haase, Kathrin, additional, Sauer, Angela, additional, Liman, Jan, additional, Brehm, Alex, additional, Maus, Volker, additional, Hollstein, Nicole, additional, Reinke, Annika, additional, Neitz, Gustav, additional, Schnieder, Marlena, additional, Schwarz, Margret, additional, Ibrahim, Allam, additional, Müller, Julia, additional, Meister, Stefanie, additional, Bäumle, Berit, additional, Pilgram-Pastor, Sara, additional, Wallocha, Marta, additional, Stauder, Michael, additional, Celik, Ekin, additional, Stracke, Paul, additional, Müller, Nicole, additional, Weber, Ralph, additional, Velktamp, Roland, additional, Ringleb, Peter Arthur, additional, Heyse, Miriam, additional, Amiri, Hemasse, additional, Mundiyanapurath, Sibu, additional, Chen, Min, additional, Bevrle, Elisabeth, additional, Beck, Perdita, additional, Möhlenbruch, Markus alfred, additional, Potvin, Alphonse, additional, Harris, Cameron, additional, Wang, Chong, additional, Adams, Corey, additional, Mayor, Diana, additional, Garman, Dave, additional, Chau, Davis, additional, Wu, Jane, additional, Lunn, Janet, additional, Bermanis, Liat, additional, Teyes, Lucy, additional, Constant, Marc, additional, Galsim, Maria, additional, Helbin, Michael, additional, Leroux, Michelle, additional, Felix, Nicole, additional, Bendre, Nilima, additional, Cuthbert, Sandra, additional, Brokx, Steve, additional, Zhang, Yichuan, additional, Lingham, Trudy, additional, Kohli, Yatika, additional, Salter, Michael, additional, Liebeschuetz, Joseph, additional, Hofmann, Frieder, additional, Constant, John, additional, Soeder, Tom, additional, Snoke, Kara, additional, Bologa, Monica, additional, Stahl, Kimberly, additional, and Graziewicz, Maria, additional

Published
2020
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22. Frequency, Determinants, and Outcomes of Emboli to Distal and New Territories Related to Mechanical Thrombectomy for Acute Ischemic Stroke

Author

Wong, Gregory J., primary, Yoo, Bryan, additional, Liebeskind, David, additional, Baharvahdat, Humain, additional, Gornbein, Jeffrey, additional, Jahan, Reza, additional, Szeder, Viktor, additional, Duckwiler, Gary, additional, Tateshima, Satoshi, additional, Colby, Geoffrey, additional, Nour, May, additional, Sharma, Latisha, additional, Rao, Neal, additional, Hinman, Jason, additional, Starkman, Sidney, additional, Saver, Jeffrey L., additional, Alfonso, Rodel, additional, Arch, Allison, additional, Avila, Gilda, additional, Hosseini, Mersedeh Bahr, additional, Chatfield, Fionna, additional, Chhabra, Arun S., additional, Dobkin, Bruce, additional, Frischmann, Lindsey K., additional, Grunberg, Ileana, additional, Guzy, Judy, additional, Huang, Josephine F., additional, Kim, Doojin, additional, Malhotra, Konark, additional, McManus, Michael, additional, Restrepo, Lucas, additional, Singh, Parampreet, additional, Tang, Xiannan (Xander), additional, Tarpley, Jason W., additional, and Tipirneni, Anita, additional

Published
2021
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27. Abstract P13: Faster Treatment Speed is Not Associated With Bleeds: Intravenous Alteplase Treatment in the Ultra-Early Time Window is Safe

Author

Provencher, Michelle, primary, Scherman, Ashley, additional, Baraban, Elizabeth, additional, Jackson, Robert, additional, Stuchiner, Tamela L, additional, Cox, Kailey L, additional, McDonald, Kristen, additional, Tarpley, Jason W, additional, Kansara, Amit, additional, Rogers, Bronwyn S, additional, Van Horn, Christine, additional, Teeter, Lisa, additional, Fitzgerald, Darcie D, additional, and Cowell, Leigh, additional

Published
2021
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28. Imaging criteria across pivotal randomized controlled trials for late window thrombectomy patient selection

Author

Menon, Bijoy K, primary, Ospel, Johanna Maria, additional, McTaggart, Ryan A, additional, Nogueira, Raul G, additional, Demchuk, Andrew M, additional, Poppe, Alexandre, additional, Rempel, Jeremy L, additional, Zerna, Charlotte, additional, Joshi, Manish, additional, Almekhlafi, Mohammed A, additional, Field, Thalia S, additional, Dowlatshahi, Dariush, additional, van Adel, Brian Anthony, additional, Sauvageau, Eric, additional, Tarpley, Jason, additional, Moreira, Tiago, additional, Bang, Oh Young, additional, Heck, Don, additional, Psychogios, Marios N, additional, Tymianski, Michael, additional, Hill, Michael D, additional, and Goyal, Mayank, additional

Published
2020
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29. Recanalization following Endovascular treatment and imaging of PErfusion, Regional inFarction and atrophy to Understand Stroke Evolution—NA1 (REPERFUSE-NA1)

Author

Tariq, Sana, primary, Sah, Rani Gupta, additional, Chan, Leona, additional, Rajashekar, Deepthi, additional, McTaggart, Ryan, additional, Butcher, Kenneth, additional, Aviv, Richard, additional, Swartz, Rick, additional, Field, Thalia, additional, Tarpley, Jason, additional, Shah, Ruchir, additional, Hill, Michael, additional, Demchuk, Andrew, additional, Goyal, Mayank, additional, d’Esterre, Christopher D, additional, and Barber, Philip A, additional

Published
2020
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33. Imaging criteria across pivotal randomized controlled trials for late window thrombectomy patient selection.

Author

Menon, Bijoy K., Ospel, Johanna Maria, McTaggart, Ryan A., Nogueira, Raul G., Demchuk, Andrew M., Poppe, Alexandre, Rempel, Jeremy L., Zerna, Charlotte, Joshi, Manish, Almekhlafi, Mohammed A., Field, Thalia S., Dowlatshahi, Dariush, van Adel, Brian Anthony, Sauvageau, Eric, Tarpley, Jason, Moreira, Tiago, Oh Young Bang, Heck, Don, Psychogios, Marios N., and Tymianski, Michael

Subjects
BLOOD vessels, PATIENT selection, ISCHEMIC stroke, INFARCTION, OPERATIVE surgery, SURGERY, PATIENTS, RADIONUCLIDE imaging, RANDOMIZED controlled trials, VEIN surgery, WORKFLOW, TREATMENT effectiveness, THROMBECTOMY, DESCRIPTIVE statistics, COMPUTED tomography, ENDOVASCULAR surgery, REPERFUSION, PERFUSION
Abstract

Background The DAWN and DEFUSE-3 trials showed the benefit of endovascular treatment (EVT) in acute ischemic stroke patients presenting beyond 6 hours from last known well (LKW) and selected by perfusion imaging criteria. The ESCAPE NA1-trial selected patients based on non-contrast CT (NCCT) Alberta Stroke Program Early CT Score (ASPECTS) and multiphase CT angiography (CTA) collateral status. This study compares baseline characteristics, workflow, and outcomes in the EVT arms of DAWN and DEFUSE-3 with late-window patients from the EVT-only arm of ESCAPE-NA1. Methods Aggregate data on baseline characteristics, workflow, reperfusion quality, final infarct volume, and clinical outcomes (modified Rankin Score [mRS] at 90 days) in subjects enrolled in the DAWN and DEFUSE-3 EVT arms were compared with similar data from the ESCAPE-NA1 control arm (EVT-only arm) presenting beyond 6 hours from LKW using descriptive statistics. Results Baseline characteristics among late-window patients in the ESCAPE NA1 trial were similar to those in the DAWN and DEFUSE-3 EVT arms. Median time from LKW-to-puncture in subjects enrolled in the ESCAPE NA1 trial was 9 hrs (IQR: 7.5--11 hours) when compared with DAWN (n=107; 12.8 hours, IQR: 10.6--16.7 hours) and DEFUSE-3 (n=92; 11.5 hours, IQR: 9.2--12.8 hours). Median post-treatment infarct-volume was largest in the ESCAPE NA1-patients (47 mL [IQR: 19--146] vs median 8 mL [IQR: 0--48] in the DAWN group and 35 mL [IQR: 18--82] in DEFUSE-3), while % mRS 0--2 at 90 days were similar across the three trials (ESCAPE NA1: 50/111 [45%], DAWN: 52/107 [49%], DEFUSE-3: 41/92 [45%]). Conclusion Patients enrolled beyond 6 hours from LKW in the ESCAPE-NA1 trial based on NCCT-ASPECTS and mCTA had similar clinical outcomes when compared with patients selected by perfusion imaging in the DAWN and DEFUSE-3 trials. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Abstract WMP71: Multimodal Imaging Yields Low Number of Stroke Mimics Treated With Thrombolytic Therapy Without Sacrificing Door-to-Needle Times

Author

Arch, Allison E, primary, Starkman, Sidney, additional, Yoo, Bryan, additional, Alfonso, Rodel, additional, Shkirkova, Kristina, additional, Huang, Josephine, additional, Nour, May, additional, Tarpley, Jason, additional, McManus, Michael, additional, Kleinman, Jonathan T, additional, Vespa, Paul M, additional, Buitrago-Blanco, Manuel, additional, Ng, Kwan L, additional, Kim, Doojin, additional, Hinman, Jason D, additional, Rao, Neal, additional, Ali, Latisha K, additional, Liebeskind, David S, additional, and Saver, Jeffrey L, additional

Published
2016
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41. Feasibility and utility of an integrated medical imaging and informatics smartphone system for management of acute stroke.

Author

Shkirkova, Kristina, Akam, Eftitan Y., Huang, Josephine, Sheth, Sunil A., Nour, May, Liang, Conrad W., McManus, Michael, Trinh, Van, Duckwiler, Gary, Tarpley, Jason, Vinuela, Fernando, and Saver, Jeffrey L.

Subjects
STROKE, DIAGNOSTIC imaging, MEDICAL informatics, CEREBROVASCULAR disease, MEDICAL imaging systems
Abstract

Background: Rapid dissemination and coordination of clinical and imaging data among multidisciplinary team members are essential for optimal acute stroke care. Aim: To characterize the feasibility and utility of the Synapse Emergency Room mobile (Synapse ERm) informatics system. Methods: We implemented the Synapse ERm system for integration of clinical data, computerized tomography, magnetic resonance, and catheter angiographic imaging, and real-time stroke team communications, in consecutive acute neurovascular patients at a Comprehensive Stroke Center. Results: From May 2014 to October 2014, the Synapse ERm application was used by 33 stroke team members in 84 Code Stroke alerts. Patient age was 69.6 (±17.1), with 41.5% female. Final diagnosis was: ischemic stroke 64.6%, transient ischemic attack 7.3%, intracerebral hemorrhage 6.1%, and cerebrovascular-mimic 22.0%. Each patient Synapse ERm record was viewed by a median of 10 (interquartile range 6-18) times by a median of 3 (interquartile range 2-4) team members. The most used feature was computerized tomography, magnetic resonance, and catheter angiography image display. In-app tweet team, communications were sent by median 1 (interquartile range 0-1, range 0-13) users per case and viewed by median 1 (interquartile range 0-3, range 0-44) team members. Use of the system was associated with rapid treatment times, faster than national guidelines, including median door-to-needle 51.0 min (interquartile range 40.5-69.5) and median door-to-groin 94.5 min (interquartile range 85.5-121.3). In user surveys, the mobile information platform was judged easy to employ in 91% (95% confidence interval 65%-99%) of uses and of added help in stroke management in 50% (95% confidence interval 22%-78%). Conclusion: The Synapse ERm mobile platform for stroke team distribution and integration of clinical and imaging data was feasible to implement, showed high ease of use, and moderate perceived added utility in therapeutic management. [ABSTRACT FROM AUTHOR]

Published
2017
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45. Block of Peripheral Nerve Sodium Channels Selectively Inhibits Features of Neuropathic Pain in Rats

Author

Brochu, Richard M., primary, Dick, Ivy E., additional, Tarpley, Jason W., additional, McGowan, Erin, additional, Gunner, David, additional, Herrington, James, additional, Shao, Pengcheng P., additional, Ok, Dong, additional, Li, Chunshi, additional, Parsons, William H., additional, Stump, Gary L., additional, Regan, Christopher P., additional, Lynch, Joseph J., additional, Lyons, Kathryn A., additional, McManus, Owen B., additional, Clark, Samantha, additional, Ali, Zahid, additional, Kaczorowski, Gregory J., additional, Martin, William J., additional, and Priest, Birgit T., additional

Published
2005
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46. Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain

Author

Liang, Jun, primary, Brochu, Richard M., additional, Cohen, Charles J., additional, Dick, Ivy E., additional, Felix, John P., additional, Fisher, Michael H., additional, Garcia, Maria L., additional, Kaczorowski, Gregory J., additional, Lyons, Kathryn A., additional, Meinke, Peter T., additional, Priest, Birgit T., additional, Schmalhofer, William A., additional, Smith, McHardy M., additional, Tarpley, Jason W., additional, Williams, Brande S., additional, Martin, William J., additional, and Parsons, William H., additional

Published
2005
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48. Animal Models of Neuropathic Pain.

Author

Walker, John M., Pan, Zhizhong Z., Martin, William J., Stewart, Laike St. A., and Tarpley, Jason W.

Abstract

Despite its prevalence, nerve injury-related (neuropathic) pain in humans is not well understood and, as such, remains difficult to manage (1-3). A variety of clinical conditions can lead to neuropathic pain, which contributes to our lack of understanding of this phenomenon. Although there is substantial etiological heterogeneity among neuropathic pain conditions, commonalities exist. For example, most patients present with combinations of spontaneous and stimulus-evoked pain, the latter of which is characterized by a hypersensitivity to previously innocuous tactile or thermal stimuli (allodynia). To improve our understanding of neuropathic pain, the challenge for basic scientists has been twofold: 1) to develop animal models of persistent pain that more closely mimic clinical pain in humans; and 2) to ensure high reproducibility, within and between animals, across different investigators and laboratories. [ABSTRACT FROM AUTHOR]

Published
2003
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49. Unilateral Storage of Fear Memories by the Amygdala.

Author

Blair, Hugh T., Huynh, Virginia K., Vaz, Vanessa T., Van, John, Patel, Reekesh R., Hiteshi, Amit K., Lee, Jennie E., and Tarpley, Jason W.

Subjects
CLASSICAL conditioning, FEAR, PAIRED associate learning, AMYGDALOID body, LEARNING, MEMORY
Abstract

Pavlovian fear conditioning is an associative learning task in which subjects are trained to respond defensively to a neutral conditioned stimulus (CS) by pairing it with an aversive unconditioned stimulus (US). This type of learning depends critically on the amygdala, and evidence suggests that synaptic plasticity within the lateral nucleus of the amygdala (LA) may be responsible for storing memories of the CS-US association. In the present study, we trained rats to fear an auditory CS by pairing it with a shock US delivered to one eyelid. Conditioning was assessed by measuring freezing responses evoked by the CS during a subsequent test session. The amygdala was unilaterally inactivated during either the training or the testing session by intracranial infusions of muscimol into the LA. We found that both acquisition and expression of conditioned freezing to the CS depended on the amygdala contralateral but not ipsilateral from the eyelid where the shock US was delivered. To explain this surprising result, we propose that the shock US is relayed from the eyelid to the amygdala via lateralized nociceptive sensory pathways, which causes memories of the CS-US association to be stored by the amygdala contralateral but not ipsilateral from the shocked eyelid. Our results demonstrate that the fear-learning circuitry of the amygdala is functionally lateralized according to the anatomical source of predicted threats. In future studies, the cellular mechanisms of emotional memory storage might be pinpointed by identifying cellular processes that occur only in the amygdala contralateral but not ipsilateral from the US during lateralized fear conditioning. [ABSTRACT FROM AUTHOR]

Published
2005
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50. The behavioral and neuroanatomical effects of IB4-saporin treatment in rat models of nociceptive and neuropathic pain

Author

Tarpley, Jason W., Kohler, Martin G., and Martin, William J.

Subjects
*RATS, *PAIN, *NEURONS, *NEUROSCIENCES
Abstract

One distinguishing feature of primary afferent neurons is their ability to bind the lectin IB4. Previous work suggested that neurons in the inner part of lamina II (IIi), onto which IB4-positive sensory neurons project, facilitate nociceptive transmission following tissue or nerve injury. Using an IB4-saporin conjugate (IB4-SAP), we examined the contribution of IB4-positive neurons to nociceptive processing in rats with and without nerve injury. Intrasciatic injection of IB4-SAP (5 μg/5 μl) significantly decreased IB4-labeling and immunoreactive P2X3 in the spinal cord and delayed the behavioral and neuroanatomical consequences of L5 spinal nerve ligation (SNL) injury. In the absence of injury, thermal and mechanical nociceptive thresholds increased 2 weeks post-treatment only in IB4-SAP-treated, but not control (saline or saporin only), rats. Acute NGF-induced hyperalgesia was also attenuated following IB4-SAP treatment. In the SNL model, mechanical allodynia failed to develop 1 and 2 weeks post-injury, but was fully established by 4 weeks. Moreover, neuropeptide Y immunoreactivity (NPY-ir), which increases in the spinal cord after nerve injury, was unchanged in IB4-SAP-treated animals whereas immunoreactive PKCγ decreased 2, but not 4, weeks post-injury. Quantitative RT-PCR revealed a reduction in P2X3 mRNA in L4 DRG of IB4-SAP-treated animals, but no change in TrkA expression. Our results suggest that IB4-positive neurons in L4 are required for the full expression of NGF-induced hyperalgesia and participate in the behavioral and anatomical consequences that follow injury to the L5 spinal nerve. [Copyright &y& Elsevier]

Published
2004
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