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Supplemental material, review_MW_Supplementary_Table_3_final for Adverse events associated with home use of mouthrinses: a systematic review by Gianluca M. Tartaglia, Santosh Kumar Tadakamadla, Stephen Thaddeus Connelly, Chiarella Sforza and Conchita Martín in Therapeutic Advances in Drug Safety

Advances in the upper airway imaging allow to better evaluate and understand their morphology, pathology and mechanics [1]. In particular, Cone beam CT technology (CBCT), with its isotropic spatial resolution, undistorted images, X-ray lower radiation exposure, versatility and relatively low cost, takes over other imaging modalities [2]. The purpose of this study is to evaluate whether CBCT scans can be valuable tools for the extraction of quantitative parameters to confirm the deviation of the nasal septum in a specific patient. First, we assessed the difference in angle of septal deviation, calculated as proposed by Orhan et al., among a control group and a patient group [3]. Subsequently, we evaluated the percentage difference between the volume of the upper airways in the right side and left side of the nose in the same sample. The measurements were performed on 23 CBCT scans of Caucasian adult women, divided into 7 control subjects and 16 patients. The results demonstrate that there is a significant difference both in the deviation angle (p0.05); random errors explained 0.77% (angle) and 0.99% (volume) of the sample variance. Paired Student’s t tests were used for comparisons. In particular, the volume difference appears to be less sensitive to the presence of isolated cartilaginous ridges that increase the angle of deviation even if the septum is not pathological. This makes it more suited to the identification of this pathology. The obtained outcomes are encouraging and it is advisable to continue the study on a larger sample., Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014

The aim of this study was to verify if patients with arthrogenous temporomandibular disorders (TMD) with different Magnetic Resonance Imaging (MRI) diagnoses had some objective differences in the surface electromyography (sEMG) characteristics of their masticatory muscles. Twenty-four TMD patients were categorized according to the RDC/TMD [1]; MRI classified patients with disk displacement (DD, mean age 22 years, SD 5; M/F: 3/6), and osteoarthrosis and/or disk displacement (OA, mean age 37 years, SD 10; M/F: 4/11). sEMG of the right and left masseter and anterior temporalis muscles was performed according to a standardized protocol, recording teeth clenching on either cotton rolls or occlusal surfaces [2]. EMG data were compared to those collected in control subjects of similar age and sex, and EMG z-scores were computed. The comparison of EMG z-scores and MRI scores between the 2 patient groups using the Mann-Whitney test was statistically significant (P < 0.05): the patients with OA had larger scores than the patients with only DD. The linear correlation analysis run between the EMG and the MRI scores found significant correlations in both patient groups. The EMG characteristics allowed to well differentiate patients with MRI diagnosis of DD or OA. The objective recording of the masticatory muscle function and dysfunction through sEMG can be a first simple and low cost diagnostic approach to TMD patients., Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012

The temporomandibular joint (TMJ) is a complex synovial articulation, made by the mandibular condyles and the squamous surface of temporal bones. The skeletal surfaces are highly incongruent and are separated by a fibrous disc, that reduces joint incongruence, increases joint stability, and allows mandibular movements with six degrees-of-freedom. In mammals, TMJ characteristics are so unique that are used to define the class Mammalia. TMJ development is strictly related to that of the middle ear, and it represents a complex modification of a phylogenetically older articulation found in non-mammalian vertebrates [1]. In particular, human TMJ possesses several differences from that of the other mammals, and animal models cannot be easily used to investigate its dynamic and kinematic characteristics. Several hypotheses have been proposed to describe TMJ movements and intra-articular force, but a major limitation lies in the difficulty in the actual assessment of condylar movements. Indeed, no current imaging system can provide a complete three-dimensional evaluation of TMJ motion: conventional radiographic images lack the third dimension and cannot inform about the behaviour of soft tissues; CT provides all three spatial planes but still cannot image the disc and related structures; magnetic resonance (MR), while providing adequate details of soft tissue structures, lacks the necessary dynamic information. Therefore, most of these studies are based on biomechanical models, where TMJ motion is recorded with three-dimensional motion analyzers, and mathematical and geometrical calculations provide the necessary background for the hypotheses about joint mechanical behaviour [2]., Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013

Introduction. The occlusal plane has a key-role in various dental and medical fields. Several methods have analyzed and measured the relative positions of the occlusal and facial planes; most of these investigations used 2D radiographic exams. Currently, 3D assessments may be performed overlapping CT reconstructions and digitized dental casts, but the method requires ionizing radiations, and it is not applicable in reference studies performed with healthy subjects. The efficacy of these measurements could be improved by a 3D, non invasive approach to the problem. Methods. 20 healthy subjects were selected to have their maxillary dental casts digitized by laser scanning, and their 3D facial soft tissue stereophotogrammetry acquisition merged in a single file. The digital 3D coordinates of three facial (right and left Tragus, Subnasale) and three dental landmarks (inter-incisor, tips of the mesio-vestibular cuspids of right and left first permanent molars), were obtained and exported in a 3D CAD (computed aided design) software for a geometrical analysis. The 3D orientation of the planes, referred to a Cartesian orthogonal reference system, was estimated calculating angular values between the sagittal midlines of the two planes. To evaluate the repeatability of the measurements the protocol was performed independently by two different operators. In total 120 measurements were obtained; descriptive statistics were calculated for each variable. To evaluate the method repeatability mean absolute difference between repeated measurements (MAD), technical error of measurement (REM) and Paired Student’s T tests (P 0.05). Conclusions. The current non-invasive method resulted appropriate to the aims. Camper’s and occlusal planes resulted almost parallel in the frontal and horizontal projections, while in the sagittal projection the occlusal plane was 5 degrees more anteriorly inclined than Camper’s plane., Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011

Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010