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Introduction: Non-diabetic individuals with type II diabetic parents are more susceptible to develop Diabetes. Visfatin; an adipocytokine and an enzyme is linked with glucose metabolism and affected by obesity. It works like insulin in the human body. It serves as a key enzyme in nicotinamide adenine dinucleotide biosynthesis and plays a pivotal role in glucose mediated insulin secretion. Aims and Objectives: In this study we aimed to determine and compare serum visfatin levels, insulin resistance (HOMA-IR) and beta cell function (HOMA-%B) of type II diabetic patients and non-diabetic adult offspring of type II diabetic parents with that of non-diabetic adult offspring of non-diabetic parents. Material and methods It was a cross-sectional comparative study conducted at Diabetes clinic of Lahore General Hospital (LGH) and department of Physiology, Post Graduate Medical Institute (PGMI), Lahore in 2018. The study groups included thirty type II diabetic subjects (group III) and forty non-diabetic adult offspring of type II diabetic parents (group II). Forty non-diabetic adult offspring of non-diabetic parents served as controls (group I). The subjects were of thirty to fifty years of age. Blood pressure, BMI and waist circumference of every subject was measured. Fasting blood samples of the subjects were analyzed for serum insulin, glucose and visfatin. Insulin resistance (HOMA-IR), insulin sensitivity (HOMA-%S) and beta cell function (HOMA-%β) were also calculated. Results Type II diabetics (group III) had significantly higher serum visfatin, HOMA-IR, and lower HOMA-%S as compared to the controls (group I). No significant difference was found between HOMA-%B of group III and controls. On the contrary, non-diabetic adult offspring of type II diabetic parents (group II) had significantly lower serum visfatin and HOMA-%S while HOMA-%β, HOMA-IR was significantly higher in comparison to the control group (group I). Conclusion Visfatin production seems suppressed in non-diabetic individuals with type II diabetic parents probably due to hyperinsulinemia. Moreover, it has a little role in insulin secretion in these individuals as reflected by their higher HOMA-%B index. However, visfatin’s upregulation in chronic hyperglycemia is indicative of its restorative role in the declined beta-cell function in type II diabetics.

The aim of this cross-sectional comparative study was to determine and compare fasting serum resistin and fasting blood glucose (FBG) level in the newly diagnosed pulmonary tuberculosis (TB) patients having and not having diabetes mellitus type 2 (DM). Eighty four male subjects were divided equally into groups. Group 1, healthy controls (n=28), group 2, newly diagnosed patients of pulmonary tuberculosis without DM (n=28) and group 3 included new pulmonary TB patients with newly diagnosed DM type 2 (n=28). Serum resistin and fasting blood glucose levels were determined before starting anti-TB and hyperglycemia treatment.Severity of TB was determined by analysis of sputum for bacterial load. Fasting serum resistin was done by ELISA and fasting blood Glucose by a glucose oxidase kit. Fasting blood glucose showed a significant difference between the three study groups (p= 0.000). Fasting serum resistin levels did not show a statistically significant (p= 0.098) difference between the groups. However a significant difference in serum resistin levels (p= 0.029) was observed when the TB patients were divided according to sputum smear analysis reports. Disease severity can influence serum resistin levels. Hyperglycemia present in the TB non-diabetic patients before starting ATTshould be taken into consideration.

Background: Diabetes, low nighttime blood pressure, and nonarteritic ischemic optic neuropathy may be associated. Not too many studies present whether this relationship applies to patients. Objective: Diabetes mellitus, low blood pressure at night, and nonarteritic ischemic optic neuropathy were studied in a group of individuals. Methods: The ophthalmology clinic will conduct a cross-sectional research on patients with nonarteritic ischemic optic neuropathy from March 2019 to December 2021. Nonarteritic ischemic optic neuropathy patients were tested for diabetes. Some participants wore ambulatory blood pressure monitors during the trial. Nighttime blood pressure drops are typical, muted, severe, and reverse. Results: Nonarteritic ischemic optic neuropathy was identified in 67 individuals. 587 of 67 patients were selected. 34 patients (50.7%) had diabetes, while 39 (58.2%) had hypertension. 32 people's blood pressure dropped during sleep. Only four (5.9%) saw substantial drops. Conclusions: Diabetes may be linked to nonarteritic ischemic optic neuropathy, but not nocturnal blood pressure declines. Keywords: Optic Neuropathy, Diabetes Mellitus, Hypertension