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Amaç: Glioblastoma Multiforme (GBM) erişkinlerde en sık görülen primer malign beyin tümörüdür. Optimal tedavisi, mümkün olan en geniş cerrahi rezeksiyon (maksimum güvenli rezeksiyon) sonrasında adjuvan eşzamanlı kemoradyoterapi ve ardından adjuvan kemoterapidir. Fakat, geriatrik grup optimal tedavi edilmemektedir. Son çalışmalarda genç hastalarla benzer olarak yaşlı grupta da optimal tedavinin fayda sağladığı gösterilmiştir. Biz de, 65 yaş ve üstü GBM’li hastalarda optimal tedavinin sağkalım üzerine etkisini araştırmayı amaçladık.Yöntemler: Pamukkale Üniversitesi Tıp Fakültesi Tıbbi Onkoloji Polikliniğinde 2010-2018 yılları arasında takip edilen GBM patolojik tanılı 71 hastanın dosyaları retrospektif olarak değerlendirildi. Hastaların demografik ve klinikopatolojik özellikleri dosyadan kaydedildiBulgular: Değerlendirilen 71 hastanın 25’i (%35,2) 65 yaş ve üstü, 46’sı (%64,8) 65 yaş altındaydı. Yirmi beş hastanın 11’i (%44) erkek, 14’ü (%56) kadındı. Tüm hasta grubunda ortanca takip süresi 16,2 ay (12,4-19,9), ortanca genel sağkalım süresi 12,5 ay (10,4-14,7 ay) idi. Altmış beş yaş altı hastaların ortanca genel sağkalımı 15,1 ay (12,6-17,6 ay), 65 yaş ve üstü hastaların ise 8,6 ay (7,9-9,3 ay) idi (p

Objective:Apoptosis plays a critical role in carcinogenesis. Intracellular proteases known as caspase-9 directly or indirectly playroles inactivating apoptosis. In this study, we aimed to investigate the effect of caspase-9 level in lung skuamous cancer tumor tissues on lymphnode metastasis, clinicopathologic parameters and prognosis. Material and Methods: The study included 50 patients diagnosed with squamous cell lung cancer. The caspase-9 level in the tumor and metastatic lymph nodes was assessed using real time-polymerase chain reaction(RT-PCR) methods. Results: The median age of the patients was 61 years (range, 54-68 years). All patients were men and smokers. Theaverage duration of follow-up was 50.26±39.21 months, and progression-free survival was 26.34±19.50 months. Among 50 patients, 22 (44%)had lymph node metastasis. The caspase-9 level was studied in tumors with and without lymph node metastasis. Moreover, the caspase-9 levels in tumors with lymph node metastasis were statistically and significantly lower than tumors without lymph node metastasis (p

Ovarian cancer is the most lethal gynecologic malignancy. Recent studies have shown that expression levels of toll like receptor (TLR) 4, survivin and caspase-3 in cancerous tissue may have a prognostic value in many cancer types including ovarian cancer. In the present study, we aimed to investigate the relationship between immunohistochemical expression of TLR4, survivin and caspase-3 and also to assess the effects on clinicopathological variables and survival parameters. Eighty four patients with ovarian cancer who treated between 2011 and 2019 were reviewed retrospectively. TLR4, survivin and caspase-3 levels that were obtained with immunohistochemistry from the tumor embedded in paraffin blocks. TLR4 expression was found higher in advanced stage compared to the early stage disease (p= 0.034). TLR4 positivity was inversely associated with lower caspase-3 expresion (p= 0.03) and survivin expression was closely related to capsule rupture (p= 0.037). Kaplan-Meier analysis demonstrated that stage, grade, lymphovascular invasion, and platinum sensitivity were significantly associated with progression free survival. Stage and adjuvant chemotherapy were also found to be significantly associated with overall survival. In Cox multivariate analysis, comparison according to lower versus higher TLR4 expression demonstrated that higher TLR4 expression was significantly associated with decreased overall survival (HR: 0.303; 95% CI: 0.109 to 0.847; p= 0.023). But, there was no association between survival parameters and either survivin or caspase-3 levels. As a result, TLR4 expression may have a prognostic role in ovarian cancer. © 2022, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved.

Objectives: The knowledge of the possible differences in the clinical course of COVID-19 infection in cancer patients receiving treatment has not been sufficient to conclude. In this study, we retrospectively evaluated lymphocyte counts, LDH levels, neutrophil/lymphocyte ratios (NLR), platelet lymphocyte ratios (PLR), CRP albumin ratios (CRP/Alb), LDH/ albumin ratios in COVID-19 infected cancer patients actively treated in our clinic. Methods: Cancer patients who were currently under treatment in Department of Medical Oncology, Faculty of Medicine, Pamukkale University during the period between September 2020 and April 2021 were included in the study. During the period, 1363 stage 3-4 patients were received parenteral treatment and 60 patients were diagnosed with COVID-19 infection. Results: The median age of the patients was 60 years (range 19-82 years). Stage of cancer (p=0.028), lymphopenia (p

Purpose: Colorectal cancer is the third leading diagnosis accounting for nearly 10% of all new cancers worldwide. The distinct features among BRAF mutant colorectal cancers make these tumor groups hard to treat for oncologists. The median overall survival (OS) of these types of cancers is reported to be 9 to 14 months. Methods: The study was declared on the Turkish Oncology Study Group Conference and approved. The patients’ data was received from the centers who confirmed to participate. The BRAF-mutated patients were included in the study. The demographic features (age, gender, etc.), type of mutation, tumor localizations, histology, microsatellite instability (MSI) status, metastasis patterns chemotherapeutic agents and progression, and death times were recorded. Results: Thirty-nine patients were enrolled in the study. Sixteen patients had concurrent KRAS mutations, while 7 had NRAS mutations. Most of the patients received doublet chemotherapies in combination with anti-VEGF agents in the first and second line of the treatment. There was a significant difference in OS according to the stage which showed a decreased survival in stage IV patients at the time of diagnosis. Concurrent KRAS mutation resulted in increased OS. The median OS was 47 and 24 months favoring the KRAS mutant group. The patients whose primary tumor operated had better survival when compared with other patients. The median OS of the operated group was 47 months, while the non-operated group was 24 months. Liver metastasis was related to worse prognosis at the time of diagnosis in univariate analysis. Conclusion: In our study we found a high concurrent RAS mutation ratio in a BRAF mutant patient group which was different from prior studies. The concurrent mutations resulted in a favorable outcome in terms of OS which is also different from the current knowledge. More prospective studies are needed especially BRAF-mutated patient population and especially with concurrent RAS mutations. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Objectives: Megestrol acetate (MA) can induce significant secondary adrenal suppression. We designed this study to determine the extent of adrenal insufficiency in cancer patients receiving MA and whether ther was any predictive factor for this., Methods: Thirty-one patients (aged 48-83 years) who were receiving MA took part in this study. Serum concentrations of TSH, ACTH, free T4, cortisol were measuresd in samples obtained at 7 AM, at baseline and 1st month. Standart ACTH (250 mg) stimulation test was performed if cortisol levels were below 18 mu g/dl at any time., Results: 1 month after drug initiation, 32% of patients were accepted as adrenal insufficient. There wasn't any correlation between the basal cortisol, ACTH levels, any biochemical parameter and overall survival. There was negative correlation between 1 month cortisol levels and survival time (p=0.04) If cortisol levels were lower at month of theraphy survival time was longer. Cox regression analysis showed that patients having lower cortisol levels at first month had 98% lower risk of death compared to patients having higher cortisol levels (p=0.02: OR 0.12 (0.02-0.75))., Conclusion: It is important to evaluate adrenal functions especially during episodes of infection or after withdrawal of MA therapy since this may require prompt corticosteroid treatment.

PubMed ID: 30104029 Purpose: Solid pseudopapillary neoplasm (SPN) is a rare, low-grade neoplasm with excellent prognosis. In this study, we evaluated clinicopathological characteristics of patients diagnosed with SPN retrospectively. Methods: This is a retrospective study intended to characterize patients with the diagnosis of SPN between 2005 and 2015. Clinicopathological features, recurrence rate, and overall survival of 28 patients were recorded. Malignant SPN criteria were defined as the presence of distant metastasis (developed at diagnosis or during follow up) or lymph node involvement. Results: The mean age at diagnosis was 42 (range: 17-41). Among patients, 82% (n = 23) were female and 17.9% (n = 5) were male. The mean size of tumor was 5.81 cm (range: 2-15). The mean follow up period was 55.6 months, 1-year survival was 96.5% and 5-year survival rate was 88%. A total of 25 patients were alive at the end of follow-up period and 3 of the patients became exitus due to disease. Two patients had a metastatic presentation in livers at the diagnosis and metastasis developed in 3 patients during follow-up (liver of 1 patient, peritoneum in 1 patient and liver and peritoneum in 1 patient). The reason of admission was headache in 68% patients. The type of operation was frequently subtotal pancreatectomy (n = 11, 39.3%) and distal pancreatectomy (n = 10, 35.7%). Tumors were located frequently in body and tail regions (n = 18, 64.3%) and the number of patients with malignant criteria was 6 (21.4%). Although the mean age of malignant patients was significantly higher than benign patients (P = 0.046), there was no significant difference between 2 groups in terms of gender, tumor size, capsule invasion, perineural invasion, vascular invasion, and margin status. Conclusion: SPN is a rarely seen tumor with low malignity potential. Surgical resection provides long-term survival rate even in local invasion or metastasis conditions. © 2018 Elsevier Inc.

Objectives: Lung cancer is the most common cause of cancer-related deaths worldwide. The use of tobacco and tobacco products is among the leading risk factors with proven association with lung cancer, although various environmental and dietary factors have been also implicated. Vitamin D deficiency has been identified as a poor prognostic factor in advanced stage colon cancer and breast cancer. The aim of the present study was to compare 25-hydroxyvitamin D [25(OH)D] levels between patients with non-small cell lung cancer (NSCLC) at the time of diagnosis and healthy controls and to evaluate the differences in serum 25(OH)D levels across the subgroups and stages of NSCLC., Methods: A total of 462 patients with NSCLC who were followed and treated in three participating centers were compared retrospectively with and age- and sex-matched 462 healthy controls who underwent testing for serum calcium, lactate dehydrogenase (LDH), magnesium, phosphorus, creatinine, and vitamin D levels in the between January 2016 and June 2018. The patients with NSCLC were further classified according to the histological subtype., Results: The mean age was 63.46 +/- 8.86 years. The patient group was composed of 58 females (12.6%) and 404 males (87.4%). Serum 25(OH)D, calcium, LDH, and magnesium levels were significantly different between the patient and the control group (p=0.0001, p=0.0001, p=0.0001, p=0.0001, respectively). Among patients with NSCLC, serum 25(OH) D was significantly lower in patients with adenocarcinoma subtype than in patients with squamous-cell carcinoma subtype (p=0.001). There was a significant correlation between advanced stage with decreased serum 25(OH)D and increased LDH levels (p=0.0001, p=0.0001, respectively)., Conclusion: The study is the most extensive study in our region in terms of the number of participating patients. Demonstration of a difference in serum 25(OH)D levels between histological subtypes also contributes to the literature.

Objectives: Megestrol acetate (MA) can induce significant secondary adrenal suppression. We designed this study to determine the extent of adrenal insufficiency in cancer patients receiving MA and whether ther was any predictive factor for this. Methods: Thirty-one patients (aged 48-83 years) who were receiving MA took part in this study. Serum concentrations of TSH, ACTH, free T4, cortisol were measuresd in samples obtained at 7 AM, at baseline and 1st month. Standart ACTH (250 mg) stimulation test was performed if cortisol levels were below 18 mu g/dl at any time. Results: 1 month after drug initiation, 32% of patients were accepted as adrenal insufficient. There wasn't any correlation between the basal cortisol, ACTH levels, any biochemical parameter and overall survival. There was negative correlation between 1 month cortisol levels and survival time (p=0.04) If cortisol levels were lower at month of theraphy survival time was longer. Cox regression analysis showed that patients having lower cortisol levels at first month had 98% lower risk of death compared to patients having higher cortisol levels (p=0.02: OR 0.12 (0.02-0.75)). Conclusion: It is important to evaluate adrenal functions especially during episodes of infection or after withdrawal of MA therapy since this may require prompt corticosteroid treatment.

Objectives: The aim of our study is reducing the healthcare workers' duration of exposure to the cytotoxic agents without increasing the unused dose wasting during preparation by making changes in vial sizes of cytotoxic drugs., Methods: Wasted doses and preparation time (potential exposure time) of the selected antineoplastic drugs were measured for six months. The usage of small dose vials which causes prolongation in preparation time has been avoided and larger dosage forms were preferred in last trimester. Wasted drug dose amounts and preparation periods were recorded. Subsequently, the data compared between the trimesters., Results: The total preparation period in the first trimester was 1407 minutes while it was 1058 minutes in the second trimester. There was no significant changes between the first and the last trimester of the study in terms of patients numbers that receiving chemotherapy and the rate of unused drug doses extermination (p>0.05). On the other hand, drug preparation time, in other words the health employee's exposure period to cytotoxic drugs was reduced 24.81%., Conclusion: In the study, it has been shown that by making rational choices about drug usage can reduce the healthcare workers duration of exposure to the cytotoxic agents.

Amac: Meme kanseri insidansinin artmasi ve gelisen tedaviler ile sagkalimin uzamasi izlemde yeni belirteclere gereksinim ortaya cikarmaktadir. Serum matriks metalloproteinaz 2, 7, 9 (MMP2, MMP7, MMP9), doku matriks metalloproteinaz inhibitoru1 (TIMP1), interlokin 6, interlokin 8 ve vaskuler endoteliyal buyume faktoru (VEGF) kanserogenezin farkli basamaklarinda rol almaktadirlar. Calismamizin amaci meme kanseri hastalarinda bu parametrelerin klinik evre, histopatolojik ozellikler ve laboratuar degerleri uzerine etkilerini degerlendirmektir. Gerec ve Yontem: Meme kanseri patolojik tanisi konmus kemoterapi naif yetmis sekiz kadin hasta calismaya alindi. Istatistik, Statistical Package for Social Sciences version15 ile hesaplandi. Sonuclar %95 guven araliginda degerlendirildi. p

Purpose: Solid pseudopapillary neoplasm (SPN) is a rare, low-grade neoplasm with excellent prognosis. In this study, we evaluated clinicopathological characteristics of patients diagnosed with SPN retrospectively. Methods: This is a retrospective study intended to characterize patients with the diagnosis of SPN between 2005 and 2015. Clinicopathological features, recurrence rate, and overall survival of 28 patients were recorded. Malignant SPN criteria were defined as the presence of distant metastasis (developed at diagnosis or during follow up) or lymph node involvement. Results: The mean age at diagnosis was 42 (range: 17-41). Among patients, 82% (n = 23) were female and 17.9% (n = 5) were male. The mean size of tumor was 5.81 cm (range: 2-15). The mean follow up period was 55.6 months, 1-year survival was 96.5% and 5-year survival rate was 88%. A total of 25 patients were alive at the end of follow-up period and 3 of the patients became exitus due to disease. Two patients had a metastatic presentation in livers at the diagnosis and metastasis developed in 3 patients during follow-up (liver of 1 patient, peritoneum in 1 patient and liver and peritoneum in 1 patient). The reason of admission was headache in 68% patients. The type of operation was frequently subtotal pancreatectomy (n = 11, 39.3%) and distal pancreatectomy (n = 10, 35.7%). Tumors were located frequently in body and tail regions (n = 18, 64.3%) and the number of patients with malignant criteria was 6 (21.4%). Although the mean age of malignant patients was significantly higher than benign patients (P = 0.046), there was no significant difference between 2 groups in terms of gender, tumor size, capsule invasion, perineural invasion, vascular invasion, and margin status. Conclusion: SPN is a rarely seen tumor with low malignity potential. Surgical resection provides long-term survival rate even in local invasion or metastasis conditions. (C) 2018 Elsevier Inc. All rights reserved. C1 [Ercelep, Ozlem; Ozcelik, Melike] Dr Lutfi Kirdar Kartal Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkey. [Ozdemir, Nuriye] Ankara Numune Training & Res Hosp, Dept Med Oncol, Ankara, Turkey. [Turan, Nedim] Gazi Univ, Dept Med Oncol, Fac Med, Ankara, Turkey. [Topcu, Turkan Ozturk] Karadeniz Tech Univ, Dept Med Oncol, Fac Med, Trabzon, Turkey. [Uysal, Mukremin] Afyon Kocatepe Univ, Dept Med Oncol, Fac Med, Afyon, Turkey. [Tanriverdi, Ozgur] Mugla Sitki Kocaman Univ, Dept Med Oncol, Fac Med, Mugla, Turkey. [Demirci, Umut] Ankara Yurtaslan Oncol Hosp, Dept Med Oncol, Ankara, Turkey. [Taskoylu, Burcu Yapar] Pamukkale Univ, Dept Med Oncol, Fac Med, Denizli, Turkey. [Urakci, Zuhat] Dicle Univ, Dept Med Oncol, Fac Med, Diyarbakir, Turkey. [Duran, Ayse Ocak] Kayseri Erciyes Univ, Dept Med Oncol, Fac Med, Kayseri, Turkey. [Aksoy, Asude] Malatya Inonu Univ, Dept Med Oncol, Fac Med, Malatya, Turkey. [Menekse, Serkan] Celal Bayar Univ, Dept Med Oncol, Fac Med, Manisa, Turkey. [Gumus, Mahmut] Bezmi Alem Vakif Univ, Dept Med Oncol, Fac Med, Istanbul, Turkey.

Purpose: Theraising incidence of breast cancer and development of treatment modalitiescause prolongation of survival and new markers are needed for follow up. Serummatrix metalloproteinase 2, 7, 9 (MMP2, MMP7, MMP9), tissue matrixmetalloproteinase inhibitor 1 (TIMP1), interleukin 6, interleukin 8 andvasculer endotelial growth factor (VEGF) take different parts oncancerogenesis. The aim of study is to evaluate the relationship between thesemarkers and clinical stage, histopathologic features and laboratuary parameters.Materialsand methods: Seventyeight pathologically proven,chemotherapy naive breast cancer patients were enrolled. The analyses werecarried out using SPSS v15 and p, Amaç:Meme kanseri insidansının artması vegelişen tedaviler ile sağkalımın uzaması izlemde yeni belirteçlere gereksinimortaya çıkarmaktadır. Serum matriks metalloproteinaz 2, 7, 9 (MMP2, MMP7, MMP9),doku matriks metalloproteinaz inhibitörü1 (TIMP1), interlökin 6, interlökin 8ve vasküler endoteliyal büyüme faktörü (VEGF) kanserogenezin farklı basamaklarındarol almaktadırlar. Çalışmamızın amacı meme kanseri hastalarında buparametrelerin klinik evre, histopatolojik özellikler ve laboratuar değerleriüzerine etkilerini değerlendirmektir. Gereçve Yöntem: Meme kanseri patolojiktanısı konmuş kemoterapi naif yetmiş sekiz kadın hasta çalışmaya alındı. İstatistik,Statistical Package for Social Sciences version15 ile hesaplandı. Sonuçlar %95güven aralığında değerlendirildi. p

Central nervous system (CNS) metastasis is a rare event in the course of late stage epithelial ovarian cancer (EOC); however its incidence is increasing in parallel with prolonged survival of patients.The authors assessed the clinical parameters and potential prognostic features in patients with CNS metastatic disease.Clinical data of the 33 patients from the participating centers were retrospectively collected and analyzed. Median age at the time of CNS metastasis was 57 years. Median time from the diagnosis of primary EOC until CNS metastatic disease was 22 months. Nearly half (45.5%) of the patients had single CNS metastatic lesions and all patients in the study group except two received radiotherapy as palliative treatment. Median overall survival (OS) from the time of CNS metastasis was 15 months (0-66). At univariate analysis only number of brain metastatic lesions (p = 0.001) and presence of extracranial disease (p = 0.004) were strongly associated with OS whereas multimodal treatment, size of metastatic lesions, platinum sensitivity, age, grade, and disease stage at presentation were not. Development of CNS metastasis carries a poor prognosis, however patients with single metastatic lesions and only intracranial metastatic disease can have prolonged survival after appropriate palliative management of their disease.

Correction to: Wien Klin Wochenschr 2015 https://doi.org/10.1007/s00508-015-0854-z The original version of this article unfortunately contained a mistake. The first names of Dr. Ismail Dogu Kilic were interchanged.

Correction to: Wien Klin Wochenschr 2015 https://doi.org/10.1007/s00508-015-0854-z The original version of this article unfortunately contained a mistake. The first names of Dr. Ismail Dogu Kilic were interchanged.

Background Soft tissue sarcomas (STSs) are rare malignant tumors of embryogenic mesoderm origin. Primary thoracic STSs account for a small percentage of all STSs and limited published information is available. This study aimed to identify the prognostic factors for thoracic STSs and evaluate the disease's clinical outcomes. Methods The medical records of 109 patients with thoracic STSs who were treated between 2003 and 2013 were retrospectively reviewed. Patients' survival rates were analyzed and potential prognostic factors evaluated. Results The median follow-up period was 29 months (range: 1–121 months). STSs were most frequently localized on the chest wall (n = 42; 38.5%) and lungs (n = 42; 38.5%). The most common histological types were malignant fibrous histiocytoma (n = 23; 21.1%), liposarcoma (n = 17; 15.6%), and leiomyosarcoma (n = 16; 14.7%). The median survival time of all patients was 40.3 months (95% confidence interval, 14.22–66.37 months), with one and five-year survival rates of 93.4% and 63.5%, respectively. Univariate analysis of all groups revealed that metastatic stage, unresectability, tumor diameter of >10 cm, tumor location other than the chest wall, and grade 3 diseases were predictable of poor survival. However, only grade 3 diseases and tumor location other than the chest wall were confirmed by multivariate analysis as poor prognostic factors. Conclusions Primary thoracic STSs are rarely seen malignant tumors. Our results indicated that patients with low-grade tumors and those localized on the chest wall often experienced better survival outcomes.

Most data on prognostic factors for patients with high-grade undifferentiated pleomorphic sarcoma (HGUPS) is obtained from analyses of soft tissue sarcomas. The purpose of this study was to evaluate the clinicopathologic features and their impact on outcomes specifically in patients diagnosed with HGUPS. In this multicenter trial, we retrospectively analyzed 112 patients who were diagnosed and treated at 12 different institutions in Turkey. We collected data concerning the patients, tumor characteristics, and treatment modalities. There were 69 males (61.6 %) and 43 females (38.4 %). Median age was 56 years (19–90). The most common anatomic site of tumor origin was the upper extremity. Pleomorphic variant was the predominant histological subtype. Median tumor size was 8.2 cm (0.6–30 cm). Tumors were mainly deeply seated (57.1 %). Fifty-seven patients (50.9 %) were stage II and the remainder were stage III at the time of diagnosis. Median follow-up was 30 months (2–160). The primary site of distant metastasis was the lung (73.5 %) and the second most common site was the liver (11.7 %). The 5-year overall survival, distant metastasis-free survival, and local recurrence-free survival rates were 56.3, 53.4, and 67.2 %, respectively. Multivariate analysis showed that Eastern Cooperative Oncology Group (ECOG) performance score of II (p = 0.033), deep tumor location (p = 0.000), and development of distant metastasis (p = 0.004) were negatively correlated with overall survival, and perioperative radiotherapy and negative microscopic margins were significant factors for local control rates (p = 0.000 for each). Deep tumor location (p = 0.003) was the only adverse factor related to distant metastasis-free survival. Deep tumor location, ECOG performance score of II, and development of distant metastasis carry a poor prognostic implication on overall survival. These will aid clinicians in predicting survival and treatment decision. © 2015, International Society of Oncology and BioMarkers (ISOBM).

Coronary artery aneurysms (CAA) are uncommon and describe a localized dilatation of a coronary artery segment more than 1.5-fold compared with adjacent normal segments. The incidence of CAAs varies from 0.3% to 5.3%. Ever since the dawn of the interventional era, CAAs have been increasingly diagnosed on coronary angiography. Causative factors include atherosclerosis, Takayasu arteritis, congenital disorders, Kawasaki disease, and percutaneous coronary intervention. The natural history of CAAs remains unclear; however, several recent studies have postulated the underlying molecular mechanisms of CAAs and genome wide association studies have revealed several genetic predispositions to CAA. Controversies persist regarding the management of coronary artery aneurysms, and emerging findings support the importance of an early diagnosis in patients predisposed to CAAs, such as in children with Kawasaki disease. This review aims to summarise the present knowledge of coronary artery aneurysms and collate the recent advances regarding the epidemiology, etiology, pathophysiology, diagnosis, and treatment of this disease.

Coronary artery aneurysms (CAAs) are uncommon and describe a localized dilatation of a coronary artery segment more than 1.5-fold compared with adjacent normal segments. The incidence of CAAs varies from 0.3 to 5.3%. Ever since the dawn of the interventional era, CAAs have been increasingly diagnosed on coronary angiography. Causative factors include atherosclerosis, Takayasu arteritis, congenital disorders, Kawasaki disease (KD), and percutaneous coronary intervention. The natural history of CAAs remains unclear; however, several recent studies have postulated the underlying molecular mechanisms of CAAs, and genome-wide association studies have revealed several genetic predispositions to CAA. Controversies persist regarding the management of CAAs, and emerging findings support the importance of an early diagnosis in patients predisposed to CAAs, such as in children with KD. This review aims to summarize the present knowledge of CAAs and collate the recent advances regarding the epidemiology, etiology, pathophysiology, diagnosis, and treatment of this disease.

Akciğer kanseri de dahil olmak üzere birçok kanserde apopitozis inhibisyonu ve survivinin önemine değinen önemli çalışmalar bulunmaktadır. Bu çalışmanın amacı akciğer kanserinde survivin ekspresyonu ile prognoz ilişkisini değerlendirmektir. Skuamoz hücreli akciğer kanseri tanılı toplam 50 hasta çalışmaya alındı. Tümör ve metastatik lenf nodlarında survivin düzeyi İHK (İmmunhistokimya) ve RT-PCR (reverz transkripsiyon-polimeraz zincir reaksiyonu) yöntemleri ve klinik parametrelerle beraber değerlendirildi. Hastaların median yaş değeri 60 yıl idi. Hastaların hepsi erkekti ve hepsi sigara içicisiydiler. Ortalama takip süresi 42.08±22.46 ay, hastalıksız sağkalım süresi ise 40.62±22.46 ay olarak hesaplandı. Metastatik lenf nodundaki survivin düzeyiyle, sigara içme süresi (İHK ve RT-PCR), anjiyolenfatik invazyon varlığı (İHK) ve mitoz sayısı (RT-PCR) arasında anlamlı ilişki saptandı (sırasıyla p= 0.05, p= 0.05, p< 0.001, p= 0.02). Mutivariet analizde survivin ile anjiyolenfatik invazyon varlığı ve evre arasında anlamlı ilişki bulundu (sırasıyla, p< 0.001, p= 0.04). Tümör ve lenf nodundaki survivin seviyesi ile sağkalım arasında anlamlı ilişki bulunamadı. Lenf nodunda İHK ile saptanan yüksek survivin düzeylerinde sağkalım daha kısa olmakla beraber istatistiksel olarak anlamlılık saptanmadı. Toplumumuzda survivinin prognostik ve prediktif önemini belirlemek için daha fazla hasta sayısıyla yapılacak daha kapsamlı çalışmalara ihtiyaç vardır

There are outstanding studies on the importance of survivin and inhibition of apoptosis in many cancers, including lung. Evaluation of the relationship between survivin expression in lung cancer and prognosis is the aim of this study. A total of 50 patients with a diagnosis of squamous cell lung carcinoma were included in this study. Survivin levels that were obtained with IHC (immunohistochemical) and RT-PCR (reverse transcription-polymerase chain reaction) methods from the tumor and metastatic lymph node tissues embedded in paraffin blocks were evaluated along with clinical parameters. The median age of the patients was 60 years (range 54-69). All patients were male and all of them were smokers. The mean duration of follow-up and disease-free survival was 42.08±22.46 months and 40.62±22.46 months, respectively. Significant associations were found among survivin levels in metastatic lymph nodes and duration of smoking (IHC and RT-PCR), angiolymphatic invasion (IHC), the number of mitosis (RT-PCR) (p= 0.05 and p= 0.05, p< 0.001, p= 0.02, respectively). Survivin showed statistically significant associations with angiolymphatic invasion and stage in multivariate analysis (p< 0.001, p= 0.04, respectively). An association was not found between survivin levels in tumor and lymph nodes and survival. Higher survivin levels in lymph nodes detected by IHC was associated with shorter survival but that didn’t reach statistical significance (65.22±5.16 vs 42.33±11.97, p= 0.72). Further larger studies done with larger numbers of patients are required in order to evaluate its effects in our society. © 2017, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved.

There are outstanding studies on the importance of survivin and inhibition of apoptosis in many cancers, including lung. Evaluation of the relationship between survivin expression in lung cancer and prognosis is the aim of this study. A total of 50 patients with a diagnosis of squamous cell lung carcinoma were included in this study. Survivin levels that were obtained with IHC (immunohistochemical) and RT-PCR (reverse transcription-polymerase chain reaction) methods from the tumor and metastatic lymph node tissues embedded in paraffin blocks were evaluated along with clinical parameters. The median age of the patients was 60 years (range 54-69). All patients were male and all of them were smokers. The mean duration of follow-up and disease-free survival was 42.08 +/- 22.46 months and 40.62 +/- 22.46 months, respectively. Significant associations were found among survivin levels in metastatic lymph nodes and duration of smoking (IHC and RT-PCR), angiolymphatic invasion (IHC), the number of mitosis (RT-PCR) (p= 0.05 and p= 0.05, p< 0.001, p= 0.02, respectively). Survivin showed statistically significant associations with angiolymphatic invasion and stage in multivariate analysis (p< 0.001, p= 0.04, respectively). An association was not found between survivin levels in tumor and lymph nodes and survival. Higher survivin levels in lymph nodes detected by IHC was associated with shorter survival but that didn't reach statistical significance (65.22 +/- 5.16 vs 42.33 +/- 11.97, p= 0.72). Further larger studies done with larger numbers of patients are required in order to evaluate its effects in our society.