38 results on '"Tatsuro Hayakawa"'
Search Results
2. Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single‐center retrospective study
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Eriko Makino, Takahide Hashimoto, Akahito Sako, Hideki Nanasawa, Tetsuro Enomoto, Tatsuro Hayakawa, Hidetaka Hamasaki, and Hidekatsu Yanai
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antipsychotics ,polydipsia ,schizophrenia ,SIADH ,Psychiatry ,RC435-571 - Abstract
Abstract Aims Hyponatremia is a common electrolyte disorder. The severe hyponatremia has a mortality rate of 4%–40%. Psychiatric patients are likely to develop the condition because of polydipsia or the adverse effects of antipsychotics. We investigated the characteristics of patients with and without psychiatric diseases who developed severe hyponatremia. Materials and Methods We retrospectively investigated cases admitted to our hospital (all departments) between October 2012 and November 2015 with a serum sodium concentration of ≤125 mmol/l on admission. We compared patient characteristics, etiology, and clinical course between psychiatric and nonpsychiatric patients. Results In total, 123 cases (62 female) were analyzed. Psychiatric disorders were present in 69 cases (56%), including schizophrenia (n = 19), anorexia (n = 16), mood disorders (n = 14), and organic mental disorders (n = 9). The mean patient age was 63 years. The mean serum sodium concentration on admission was 119 mmol/l, and the main causes of hyponatremia were polydipsia (20%), insufficient sodium intake (18%), and syndrome of inappropriate antidiuretic hormone secretion (16%). Compared with the nonpsychiatric group, the psychiatric group was significantly younger (55 vs. 74 years), was more likely to have polydipsia (30% vs. 6%), and had a lower in‐hospital mortality (0% vs. 17%). Conclusions Our study found differences in the clinical picture between psychiatric and nonpsychiatric patients with severe hyponatremia. Clinicians need to monitor serum sodium because the symptoms of hyponatremia can mimic those of psychiatric diseases. more...
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- 2023
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3. A cross-sectional study on metabolic similarities and differences between inpatients with schizophrenia and those with mood disorders
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Yoriyasu Uju, Tetsuto Kanzaki, Yuki Yamasaki, Tadayuki Kondo, Hideki Nanasawa, Yu Takeuchi, Yuta Yanagisawa, Shun Kusanishi, Chieko Nakano, Tetsuro Enomoto, Akahito Sako, Hidekazu Yanai, Shunichi Mishima, Seisuke Mimori, Kazuei Igarashi, Tsuyoshi Takizawa, and Tatsuro Hayakawa more...
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Schizophrenia ,Mood disorders ,Estimated glomerular filtration rate (eGFR) ,Smoking ,Silent brain infarction (SBI) ,Dyslipidemia ,Psychiatry ,RC435-571 - Abstract
Abstract Background One of the main causes of death in psychiatric patients is cardiovascular diseases which are closely related with lifestyle-related diseases. Psychiatric disorders include schizophrenia and mood disorders, whose symptoms and treatment medicines are different, suggesting that they might have different metabolic disorders. Thus, we studied the differences of lifestyle-related diseases between schizophrenia and mood disorders in Japan. Methods This cross-sectional study was performed from 2015 to 2017. Study participants were 189 Japanese hospitalized patients (144 schizophrenia group, 45 mood disorders group) in the department of psychiatry at Kohnodai hospital. We examined physical disorders, metabolic status of glucose and lipid, estimated glomerular filtration rate (eGFR) and brain magnetic resonance imaging. We compared these data between schizophrenia and mood disorders groups using analysis of covariance or logistic regression analysis. In comparisons between inpatients with schizophrenia or mood disorders group and the standard, we quoted ‘The National Health and Nutrition Survey in Japan 2015’ by Ministry of Health, Labor and Welfare as the standard. Results eGFR and prevalence of smoking were significantly lower in patients with mood disorder group than those with schizophrenia group by adjustment for age. In comparisons between patients with schizophrenia group or mood disorders group and each standard, the ratio of silent brain infarction (SBI) and cerebral infarction were significantly high in both groups. Schizophrenia group showed significantly higher prevalence of diabetes, low high-density lipoprotein (HDL) cholesterolemia, metabolic syndrome and smoking than the standard. Mood disorders group had significantly high prevalence of low HDL-cholesterolemia compared with the standard. Fasting blood glucose and HbA1c were significantly higher in schizophrenia group and female mood disorders group than the standard. Female mood disorders group had significantly decreased eGFR with increased ratio of eGFR more...
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- 2020
- Full Text
- View/download PDF
4. Suicidal ideation, suicidal behaviors, and attitudes towards suicide of adolescents enrolled in the Alternative Learning System in Manila, Philippines—a mixed methods study
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Crystal Amiel M. Estrada, Daisuke Nonaka, Ernesto R. Gregorio, Cynthia R. Leynes, Ronald T. del Castillo, Paul Michael R. Hernandez, Tatsuro Hayakawa, and Jun Kobayashi
- Subjects
Suicidal ideation ,Suicide ,Attitude ,Adolescent ,(Alternative) education ,Philippines ,Arctic medicine. Tropical medicine ,RC955-962 - Abstract
Abstract Background Globally, suicide is a significant cause of death among adolescents. Previous studies conducted in high-income countries suggest that students in alternative schools are more likely to engage in suicidal behaviors than those in formal schools. This study aimed to document suicidal ideation and behaviors among adolescent learners enrolled in the Alternative Learning System (ALS) in Manila, Philippines. Methods A mixed methods study was conducted in 24 ALS centers in the city of Manila. ALS centers were stratified according to congressional district and selected using probability proportionate sampling. A cross-sectional survey to determine attitudes towards suicide and prevalence of suicidal ideation and behaviors was administered to 171 learners aged 13 to 17 years old. In-depth interviews with 18 teachers and 12 learners were conducted to explore the school psychosocial environment’s role on learners’ suicidal ideation and behaviors. Exploratory factor analysis was used to extract attitude factors. Fisher’s exact test and Student’s t-test were used to identify differences in sociodemographic characteristics and attitudes towards suicide between learners with or without suicidal ideation or behaviors. Qualitative data were analyzed using thematic analysis. Results Non-specific active thoughts were the most common type of lifetime suicidal ideation (40.9%) while passive ideation was the most common in the past month (13.5%). Aborted suicide attempt was the most frequent behavior in both lifetime (16.4%) and in the past month (4.7%). Non-fatal suicide attempt in the past month was 2.3%, reaching 12.9% for the entire lifetime. Age, sex, education, and attitudes towards suicide were significantly associated with suicidal ideation or behavior. Thematic analysis showed five themes: (1) fostering belongingness, (2) securing learners’ safety, (3) teaching philosophy, (4) teacher and learner beliefs towards suicidal behavior, and (5) availability of school-offered and community-based services. Conclusion Suicidal ideation and behaviors are prevalent among adolescent ALS learners. This study also showed a significant difference in attitudes towards suicide and sociodemographic characteristics between learners with and without suicidal ideation behaviors. It also suggests that the school psychosocial environment, through social norms and learner-teacher interactions, can potentially prevent progression of suicidal ideation to behavior, influence help-seeking, and promote mental health among learners. more...
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- 2019
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5. Addressing challenges in children’s mental health in disaster-affected areas in Japan and the Philippines – highlights of the training program by the National Center for Global Health and Medicine
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Masahide Usami, Marian Fe Theresa Lomboy, Naoko Satake, Crystal Amiel M. Estrada, Mitsuya Kodama, Ernesto R. Gregorio Jr, Yuriko Suzuki, Ramir B. Uytico, Minerva P. Molon, Ikuhiro Harada, Keita Yamamoto, Kumi Inazaki, Hirokage Ushijima, Cynthia Leynes, Jun Kobayashi, Romeo R. Quizon, and Tatsuro Hayakawa more...
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Child ,Mental health ,Training program ,Disaster ,Japan ,The Philippines ,Medicine ,Science - Abstract
Abstract Background and purpose Natural disasters such as earthquakes, typhoons, floods, and volcanic eruptions frequently occur in Republic of Philippines and mental health care for children affected by these natural disasters is a major public health concern. Aiming to train health professionals on children’s mental health, to conduct a situational analysis to identify the local needs and resources for children’s mental health, and to propose a mental health program for children that can be transferred from Japan to the Philippines, the National Center for Global Health and Medicine (NCGM) conducted a training program for children’s mental health in disaster-affected areas in Japan and the Philippines in June, October, and December, 2017. The training was organized by NCGM for the Program for International Promotion of Japan’s Healthcare Technologies and Services funded by Ministry of Health, Labour, & Welfare, Japan in relation to the Memorandum of Understanding in the Field of Healthcare between NCGM in Japan and University of the Philippines Manila, College of Public Health. Key highlights The training program consisted of classroom trainings, site visits, and round table discussions in Japan and the Philippines. The classroom trainings and site visits focused on two points: the experiences of individuals and families who survived the Great East Japan Earthquake (GEJE) in 2011 and super typhoon Haiyan in 2013 and the program and activities, especially on mental health, of various government and non-government organizations in helping the affected families and communities. The round table discussion, on the other hand, was conducted to identify challenges related to children’s mental health in disaster-affected areas and to develop recommendations to address these challenges. The major recommendations for the Philippines were to give equal emphasis to physical and psychosocial preparedness and to develop a comprehensive program to care for carers. In Japan, public health and mental health should be integrated in the Disaster Medical Service. Experts from both countries should also generate evidence on the effectiveness of interventions in reducing mental health stigma and collaborate with school personnel and communities in order to learn more about psychosocial preparedness. Finally, mental health must be mainstreamed in programs not only in Japan but also in other countries. Implications The training program enabled key stakeholders to describe the current situation of mental health in Japan and the Philippines, to identify mental health challenges common to disaster-affected areas in both countries, and to propose short- and long-term plans and recommendations. The training program is expected to address the mental health needs of children in disaster-affected areas through a responsive community-based support network. The training participants agreed to form a network and build partnerships toward the common goal of mainstreaming community-based support for children’s mental health in disaster-affected areas in Japan and the Philippines. more...
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- 2018
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6. Genome-Wide Association Study Identifies ZNF354C Variants Associated with Depression from Interferon-Based Therapy for Chronic Hepatitis C.
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Kayoko Matsunami, Nao Nishida, Naoko Kaneko, Kazuho Ikeo, Licht Toyo-Oka, Hiroshi Takeuchi, Kentaro Matsuura, Akihiro Tamori, Hideyuki Nomura, Hitoshi Yoshiji, Masatoshi Imamura, Naohiko Masaki, Tatsuro Hayakawa, Tatsuya Ide, Noritomo Shimada, Fusao Ikeda, Keisuke Hino, Shuhei Nishiguchi, Chiaki Okuse, Shunsuke Nojiri, Kazunobu Sawamoto, Katsushi Tokunaga, Takashi Joh, and Yasuhito Tanaka more...
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Medicine ,Science - Abstract
The therapeutic use of interferon (IFN) is known to cause depression that frequently interrupts treatment. To identify genetic variants associated with IFN-induced depression, we conducted a genome-wide association study (GWAS) of 224 Japanese chronic hepatitis C patients receiving IFN-based therapy in a multicenter prospective study and stratified them into two groups according to the Beck Depression Inventory, Second Edition (BDI-II) score. In the GWAS stage, we selected 42 candidate single nucleotide polymorphisms (SNPs) to perform replication analysis in an independent set of 160 subjects. The SNP rs1863918 in strong linkage disequilibrium with SNPs located around the Zinc finger 354C (ZNF354C) gene on chromosome 5 showed a significant association when the results of GWAS and replication were combined (odds ratio = 2.55, P = 7.89×10-8 in the allele frequency model), suggesting that the rs1863918 T allele was associated with IFN-induced depression. Furthermore, logistic regression analysis showed that rs1863918 T allele, a history of depression, and younger age were independent predictive factors for IFN-induced depression. Interestingly, western blotting and immunofluorescence showed that ZNF354C was highly expressed in the hippocampus in mice, a region implicated in the pathology of psychiatric symptoms. In conclusion, we identified rs1863918 as significantly associated with IFN-induced depression, and revealed that the candidate gene ZNF354C is highly expressed in the hippocampus of mice. Our data might be useful for elucidating the pathogenic mechanisms of depression induced by drugs including IFN. more...
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- 2016
- Full Text
- View/download PDF
7. A cross-sectional study on metabolic similarities and differences between inpatients with schizophrenia and those with mood disorders
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Seisuke Mimori, Tatsuro Hayakawa, Akahito Sako, Yoriyasu Uju, Shun Kusanishi, Tetsuro Enomoto, Chieko Nakano, Shunichi Mishima, Yuki Yamasaki, Hidekazu Yanai, Kazuei Igarashi, Hideki Nanasawa, Tadayuki Kondo, Yuta Yanagisawa, Tetsuto Kanzaki, Tsuyoshi Takizawa, and Yu Takeuchi more...
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medicine.medical_specialty ,Cross-sectional study ,lcsh:RC435-571 ,behavioral disciplines and activities ,Silent brain infarction (SBI) ,Internal medicine ,Diabetes mellitus ,lcsh:Psychiatry ,mental disorders ,medicine ,Psychiatry ,business.industry ,Smoking ,Diabetes ,medicine.disease ,Psychiatry and Mental health ,Mood ,Mood disorders ,Dyslipidemia ,Schizophrenia ,Estimated glomerular filtration rate (eGFR) ,Psychopharmacology ,Metabolic syndrome ,business ,Primary Research ,Geriatric psychiatry - Abstract
Background One of the main causes of death in psychiatric patients is cardiovascular diseases which are closely related with lifestyle-related diseases. Psychiatric disorders include schizophrenia and mood disorders, whose symptoms and treatment medicines are different, suggesting that they might have different metabolic disorders. Thus, we studied the differences of lifestyle-related diseases between schizophrenia and mood disorders in Japan. Methods This cross-sectional study was performed from 2015 to 2017. Study participants were 189 Japanese hospitalized patients (144 schizophrenia group, 45 mood disorders group) in the department of psychiatry at Kohnodai hospital. We examined physical disorders, metabolic status of glucose and lipid, estimated glomerular filtration rate (eGFR) and brain magnetic resonance imaging. We compared these data between schizophrenia and mood disorders groups using analysis of covariance or logistic regression analysis. In comparisons between inpatients with schizophrenia or mood disorders group and the standard, we quoted ‘The National Health and Nutrition Survey in Japan 2015’ by Ministry of Health, Labor and Welfare as the standard. Results eGFR and prevalence of smoking were significantly lower in patients with mood disorder group than those with schizophrenia group by adjustment for age. In comparisons between patients with schizophrenia group or mood disorders group and each standard, the ratio of silent brain infarction (SBI) and cerebral infarction were significantly high in both groups. Schizophrenia group showed significantly higher prevalence of diabetes, low high-density lipoprotein (HDL) cholesterolemia, metabolic syndrome and smoking than the standard. Mood disorders group had significantly high prevalence of low HDL-cholesterolemia compared with the standard. Fasting blood glucose and HbA1c were significantly higher in schizophrenia group and female mood disorders group than the standard. Female mood disorders group had significantly decreased eGFR with increased ratio of eGFR Conclusions Participants of both groups had increased ratio of SBI and cerebral infarction, accompanied with glucose and lipid disorders. Compared with schizophrenia group, mood disorders group showed significantly low eGFR and prevalence of smoking. more...
- Published
- 2020
8. Metabolic changes of Japanese schizophrenic patients transferred from hospitalization to outpatients
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Tadayuki Kondo, Tsuyoshi Takizawa, Yuki Yamasaki, Hideki Nanasawa, Yoriyasu Uju, Tatsuro Hayakawa, Yuta Yanagisawa, Yu Takeuchi, Tetsuro Enomoto, Seisuke Mimori, Akahito Sako, Kazuei Igarashi, Shun Kusanishi, Hidekatsu Yanai, Tetsuto Kanzaki, and Chieko Nakano more...
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medicine.medical_specialty ,Triglyceride ,business.industry ,Cholesterol ,Brief Report ,Lipid metabolism ,Carbohydrate metabolism ,medicine.disease ,chemistry.chemical_compound ,chemistry ,Schizophrenia ,Internal medicine ,Medicine ,lipids (amino acids, peptides, and proteins) ,Hemoglobin ,Metabolic syndrome ,business ,Lipoprotein - Abstract
It is well known that schizophrenic patients have high incidence of metabolic syndrome and life-style related diseases. There are reports that the rates of these diseases are increased more in outpatients than inpatients, but are also reports that the rates are not different between both patient groups. These differences might be related to the length of hospitalization. Hospitalization of Japanese psychiatric patients is about 300 days, much longer than western countries (below 50 days). Therefore, we investigated lipid and glucose metabolism of schizophrenic patients transferred from hospitalization to outpatients at Kohnodai hospital with a mean of 80 days hospitalization period to clarify metabolic characteristics in Japanese patients. Study participants were 144 schizophrenia inpatients and 109 outpatients at Kohnodai Hospital. These 109 outpatients were followed for approximately 2 years, without changes of administrated drugs, and from 144 inpatients. Data from outpatients were obtained at 6 months, 1 year and 2 years after their discharge. Outpatients 2 years after discharge had significantly higher levels of total cholesterol, triglyceride and non-high density lipoprotein (non-HDL) cholesterol than inpatients, accompanied with an increase of body weight. Serum HDL-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) levels had no significant difference between both groups. These lipids and glucose levels also showed the same tendency in outpatients 0.5 year and 1 year after discharge as those after 2 years. We found that schizophrenic patients in our study appeared to have changes of lipid metabolism 2 years after their discharge, but no significant changes of glucose metabolism, such as FPG and HbA1c. more...
- Published
- 2020
9. The Risk Factors for Asymptomatic Pyuria Among Patients With Type 2 Diabetes
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Yoko Waragai, Hidekatsu Yanai, Tadayuki Kondo, Yu Takeuchi, Tatsuro Hayakawa, and Akahito Sako
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Endocrinology, Diabetes and Metabolism - Published
- 2019
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10. Additional file 1 of A cross-sectional study on metabolic similarities and differences between inpatients with schizophrenia and those with mood disorders
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Yoriyasu Uju, Tetsuto Kanzaki, Yamasaki, Yuki, Kondo, Tadayuki, Nanasawa, Hideki, Takeuchi, Yu, Yanagisawa, Yuta, Kusanishi, Shun, Nakano, Chieko, Enomoto, Tetsuro, Akahito Sako, Yanai, Hidekazu, Mishima, Shunichi, Seisuke Mimori, Kazuei Igarashi, Takizawa, Tsuyoshi, and Tatsuro Hayakawa more...
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Data_FILES - Abstract
Additional file 1
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- 2020
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11. Effects of an orexin receptor antagonist on blood pressure and metabolic parameters
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Tatsuro Hayakawa, Hidekatsu Yanai, Sumie Moriyama, and Yu Takeuchi
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business.industry ,Endocrinology, Diabetes and Metabolism ,Antagonist ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Pharmacology ,Orexin receptor ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,Text mining ,Internal Medicine ,Medicine ,Letters to the Editor ,Cardiology and Cardiovascular Medicine ,business - Published
- 2018
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12. Correlation between brain damage, associated biomarkers, and medication in psychiatric inpatients: A cross-sectional study
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Yukihiro Ishii, Tetsuya Hisaoka, Shun Kusanishi, Tetsuto Kanzaki, Yoriyasu Uju, Asuka Yasukawa, Kazuei Igarashi, Tatsuro Hayakawa, Kanako Murakami, Masafumi Miura, Seiko Okamoto, Kazumi Tsukada, Chieko Nakano, Keisuke Sekine, Mutsumi Mizoi, Yasuhiko Mizuta, Seisuke Mimori, Mamoru Sato, Taro Yoshimi, Reiko Yasui, Mizuho Nakamura, Shunichi Mishima, Takeshi Uemura, Keiko Kashiwagi, and Madoka Yoshida more...
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Adult ,Brain Infarction ,Male ,medicine.medical_specialty ,Cross-sectional study ,Clinical Biochemistry ,Brain damage ,030204 cardiovascular system & hematology ,behavioral disciplines and activities ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,mental disorders ,medicine ,Humans ,Psychiatry ,Stroke ,Inpatients ,Mood Disorders ,business.industry ,Incidence (epidemiology) ,Biochemistry (medical) ,General Medicine ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,Mood ,Mood disorders ,Schizophrenia ,Brain Injuries ,Relative risk ,Female ,medicine.symptom ,business ,Biomarkers ,030217 neurology & neurosurgery ,Antipsychotic Agents - Abstract
Background We clarified the correlation between brain damage, associated biomarkers and medication in psychiatric patients, because patients with schizophrenia have an increased risk of stroke. Methods The cross-sectional study was performed from January 2013 to December 2015. Study participants were 96 hospitalized patients (41 men and 55 women) in the Department of Psychiatry at Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan. Patients were classified into schizophrenia (n = 70) and mood disorders (n = 26) by psychiatric diagnoses with DSM-IV-TR criteria. Results The incidence of brain damage [symptomatic and silent brain infarctions (SBIs) and white matter hyperintensity (WMH)] was correlated more with mood disorders than with schizophrenia. It has been previously shown that the concentrations of protein-conjugated acrolein (PC-Acro) and interleukin-6 (IL-6) increased in plasma of brain infarction patients together with C-reactive protein (CRP). The concentration of PC-Acro was significantly higher in patients with mood disorders than in those with schizophrenia. The concentration of IL-6 in both groups was nearly equal to that in the control group, but that of CRP in both groups, especially in mood disorders, was higher than that in the control group. Accordingly, the relative risk value for brain infarction was higher in patients with mood disorders than with schizophrenia. Medication with atypical antipsychotics reduced PC-Acro significantly in all psychiatric patients and reduced IL-6 in mood disorder patients. Conclusion Measurement of 3 biomarkers (CRP, PC-Acro and IL-6) are probably useful for judgement of severity of brain damage and effectiveness of medication in psychiatric patients. more...
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- 2017
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13. Suicidal ideation, suicidal behaviors, and attitudes towards suicide of adolescents enrolled in the Alternative Learning System in Manila, Philippines-a mixed methods study
- Author
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Ronald T. del Castillo, Crystal Amiel M. Estrada, Cynthia R. Leynes, Paul Michael R. Hernandez, Tatsuro Hayakawa, Ernesto R. Gregorio, Jun Kobayashi, and Daisuke Nonaka
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lcsh:Arctic medicine. Tropical medicine ,(Alternative) education ,Adolescent ,lcsh:RC955-962 ,Philippines ,030231 tropical medicine ,education ,Poison control ,Suicide prevention ,03 medical and health sciences ,0302 clinical medicine ,Suicidal ideation ,medicine ,030212 general & internal medicine ,Suicide attempt ,Research ,Public Health, Environmental and Occupational Health ,Belongingness ,Mental health ,Suicide ,Infectious Diseases ,Attitude ,Thematic analysis ,medicine.symptom ,Psychology ,Psychosocial ,Clinical psychology - Abstract
Background Globally, suicide is a significant cause of death among adolescents. Previous studies conducted in high-income countries suggest that students in alternative schools are more likely to engage in suicidal behaviors than those in formal schools. This study aimed to document suicidal ideation and behaviors among adolescent learners enrolled in the Alternative Learning System (ALS) in Manila, Philippines. Methods A mixed methods study was conducted in 24 ALS centers in the city of Manila. ALS centers were stratified according to congressional district and selected using probability proportionate sampling. A cross-sectional survey to determine attitudes towards suicide and prevalence of suicidal ideation and behaviors was administered to 171 learners aged 13 to 17 years old. In-depth interviews with 18 teachers and 12 learners were conducted to explore the school psychosocial environment’s role on learners’ suicidal ideation and behaviors. Exploratory factor analysis was used to extract attitude factors. Fisher’s exact test and Student’s t-test were used to identify differences in sociodemographic characteristics and attitudes towards suicide between learners with or without suicidal ideation or behaviors. Qualitative data were analyzed using thematic analysis. Results Non-specific active thoughts were the most common type of lifetime suicidal ideation (40.9%) while passive ideation was the most common in the past month (13.5%). Aborted suicide attempt was the most frequent behavior in both lifetime (16.4%) and in the past month (4.7%). Non-fatal suicide attempt in the past month was 2.3%, reaching 12.9% for the entire lifetime. Age, sex, education, and attitudes towards suicide were significantly associated with suicidal ideation or behavior. Thematic analysis showed five themes: (1) fostering belongingness, (2) securing learners’ safety, (3) teaching philosophy, (4) teacher and learner beliefs towards suicidal behavior, and (5) availability of school-offered and community-based services. Conclusion Suicidal ideation and behaviors are prevalent among adolescent ALS learners. This study also showed a significant difference in attitudes towards suicide and sociodemographic characteristics between learners with and without suicidal ideation behaviors. It also suggests that the school psychosocial environment, through social norms and learner-teacher interactions, can potentially prevent progression of suicidal ideation to behavior, influence help-seeking, and promote mental health among learners. more...
- Published
- 2019
14. A comparison between augmentation with olanzapine and increased risperidone dose in acute schizophrenia patients showing early non-response to risperidone
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Yutaka Sawa, Hironori Kuga, Yasuhiko Sudo, Mitsuru Nakamura, Kazuya Hata, Chie Usui, Hiroyuki Nakamura, Kotaro Hatta, Hideaki Hayashi, Masataka Kasuya, Ryusuke Ishii, Toyoaki Hirata, Hiroshi Takebayashi, Taro Otachi, Tatsuro Hayakawa, and Fumiyoshi Morikawa more...
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Adult ,Male ,Olanzapine ,medicine.medical_specialty ,medicine.medical_treatment ,Drug Resistance ,law.invention ,Benzodiazepines ,Randomized controlled trial ,law ,Internal medicine ,Humans ,Medicine ,Single-Blind Method ,Antipsychotic ,Psychiatry ,Biological Psychiatry ,Psychiatric Status Rating Scales ,Risperidone ,Positive and Negative Syndrome Scale ,business.industry ,Confidence interval ,Discontinuation ,Clinical trial ,Psychiatry and Mental health ,Schizophrenia ,Drug Therapy, Combination ,Female ,business ,Antipsychotic Agents ,medicine.drug - Abstract
We examined whether augmentation with olanzapine would be superior to increased risperidone dose among acute schizophrenia patients showing early non-response to risperidone. We performed a rater-blinded, randomized controlled trial at psychiatric emergency sites. Eligible patients were newly admitted patients with acute schizophrenia. Early response was defined as Clinical Global Impressions-Improvement Scale score ≤ 3 following 2 weeks of treatment. Early non-responders were allocated to receive either augmentation with olanzapine (RIS + OLZ group) or increased risperidone dose (RIS + RIS group). The 78 patients who completed 2 weeks of treatment were divided into 52 early responders to risperidone and 26 early non-responders to risperidone (RIS + OLZ group, n = 13; RIS + RIS group, n = 13). No difference in the achievement of ≥ 50% improvement in Positive and Negative Syndrome Scale total score was observed between RIS + OLZ and RIS + RIS groups. Although time to treatment discontinuation for any cause was significantly shorter in the RIS + RIS group (6.8 weeks [95% confidence interval, 5.2–8.4]) than in early responders to risperidone (8.6 weeks [7.9–9.3]; P = 0.018), there was no significant difference between the RIS + OLZ group (7.9 weeks [6.3–9.5]) and early responders to risperidone. Secondary outcomes justify the inclusion of augmentation arms in additional, larger studies comparing strategies for early non-responders. more...
- Published
- 2012
- Full Text
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15. Genome-Wide Association Study Identifies ZNF354C Variants Associated with Depression from Interferon-Based Therapy for Chronic Hepatitis C
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Naoko Kaneko, Naohiko Masaki, Shunsuke Nojiri, Keisuke Hino, Noritomo Shimada, Kayoko Matsunami, Hideyuki Nomura, Kazunobu Sawamoto, Kentaro Matsuura, Tatsuya Ide, Yasuhito Tanaka, Chiaki Okuse, Nao Nishida, Akihiro Tamori, Licht Toyo-oka, Tatsuro Hayakawa, Masatoshi Imamura, Kazuho Ikeo, Shuhei Nishiguchi, Takashi Joh, Fusao Ikeda, Hitoshi Yoshiji, Hiroshi Takeuchi, and Katsushi Tokunaga more...
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0301 basic medicine ,RNA viruses ,Male ,Linkage disequilibrium ,Candidate gene ,Heredity ,lcsh:Medicine ,Genome-wide association study ,Hepacivirus ,Biochemistry ,Hippocampus ,Linkage Disequilibrium ,Polyethylene Glycols ,Database and Informatics Methods ,Mice ,0302 clinical medicine ,Medicine and Health Sciences ,lcsh:Science ,Pathology and laboratory medicine ,Multidisciplinary ,Depression ,Hepatitis C virus ,Brain ,Genomics ,Medical microbiology ,Middle Aged ,Genomic Databases ,Recombinant Proteins ,Genetic Mapping ,Viruses ,Chromosomes, Human, Pair 5 ,Female ,Anatomy ,Pathogens ,Research Article ,Adult ,Alpha interferon ,Single-nucleotide polymorphism ,Variant Genotypes ,Biology ,Research and Analysis Methods ,Microbiology ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Mental Health and Psychiatry ,Genome-Wide Association Studies ,Genetics ,Animals ,Humans ,Allele ,Allele frequency ,Aged ,Flaviviruses ,Mood Disorders ,lcsh:R ,Beck Depression Inventory ,Organisms ,Viral pathogens ,Biology and Life Sciences ,Computational Biology ,Proteins ,Interferon-alpha ,Human Genetics ,Kidneys ,Renal System ,Hepatitis C, Chronic ,Genome Analysis ,Hepatitis viruses ,Microbial pathogens ,Repressor Proteins ,030104 developmental biology ,Biological Databases ,Immunology ,lcsh:Q ,Interferons ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
The therapeutic use of interferon (IFN) is known to cause depression that frequently interrupts treatment. To identify genetic variants associated with IFN-induced depression, we conducted a genome-wide association study (GWAS) of 224 Japanese chronic hepatitis C patients receiving IFN-based therapy in a multicenter prospective study and stratified them into two groups according to the Beck Depression Inventory, Second Edition (BDI-II) score. In the GWAS stage, we selected 42 candidate single nucleotide polymorphisms (SNPs) to perform replication analysis in an independent set of 160 subjects. The SNP rs1863918 in strong linkage disequilibrium with SNPs located around the Zinc finger 354C (ZNF354C) gene on chromosome 5 showed a significant association when the results of GWAS and replication were combined (odds ratio = 2.55, P = 7.89×10−8 in the allele frequency model), suggesting that the rs1863918 T allele was associated with IFN-induced depression. Furthermore, logistic regression analysis showed that rs1863918 T allele, a history of depression, and younger age were independent predictive factors for IFN-induced depression. Interestingly, western blotting and immunofluorescence showed that ZNF354C was highly expressed in the hippocampus in mice, a region implicated in the pathology of psychiatric symptoms. In conclusion, we identified rs1863918 as significantly associated with IFN-induced depression, and revealed that the candidate gene ZNF354C is highly expressed in the hippocampus of mice. Our data might be useful for elucidating the pathogenic mechanisms of depression induced by drugs including IFN. more...
- Published
- 2016
16. Clinical Analyses of Sighted Patients with Non-24-Hour Sleep-Wake Syndrome: A Study of 57 Consecutively Diagnosed Cases
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Kayo Shibui, Masako Okawa, Tatsuro Hayakawa, Yuichi Kamei, Jujiro Urata, Kiyohisa Takahashi, Takashi Asada, Hirokuni Tagaya, and Makoto Uchiyama
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Adult ,Male ,Obsessive-Compulsive Disorder ,medicine.medical_specialty ,Pediatrics ,Neurology ,Signs and symptoms ,Severity of Illness Index ,Cohort Studies ,Sleep Disorders, Circadian Rhythm ,Intellectual Disability ,Physiology (medical) ,Interview, Psychological ,Severity of illness ,Prevalence ,medicine ,Humans ,Referral and Consultation ,Depression (differential diagnoses) ,Depressive Disorder, Major ,business.industry ,Anxiety Disorders ,Circadian Rhythm ,Cohort ,Schizophrenia ,Physical therapy ,Female ,Hour sleep ,Neurology (clinical) ,Psychiatric interview ,business ,Cohort study - Abstract
Study objectives The objective of this study was to clarify the clinical features of sighted patients with non-24-hour sleep-wake syndrome. Design Clinical analyses of consecutive patients suffering from non-24-hour sleep-wake syndrome. Setting The sleep disorders clinic at Kohnodai Hospital, National Center of Neurology and Psychiatry, Japan. Patients Fifty-seven patients who were diagnosed consecutively as having non-24-hour sleep-wake syndrome between 1991 and 2001 were included in the study. Measurements and results The clinical features and sleep characteristics of the patients were analyzed. A semistructured psychiatric interview that included the criteria for Axis I or II disorders of Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised was conducted, and relationships between psychiatric problems and non-24-hour sleep-wake syndrome were analyzed. The patient cohort included 41 (72%) men and 16 (28%) women. The onset of non-24-hour sleep-wake syndrome had occurred during the teenage years in 63% of the cohort, and the mean ( +/-SD) period of the sleep-wake cycle was 24.9 +/- 0.4 hours (range 24.4-26.5 hours). The mean sleep length of the patients was 9.3 +/- 1.3 hours, and 44% of them had a sleep length of between 9 and 10 hours. Psychiatric disorders had preceded the onset of non-24-hour sleep-wake syndrome in 16 patients (28%); of the remaining 41 patients, 14 (34%) developed major depression after the onset of non-24-hour sleep-wake syndrome. Conclusions These results represent the first detailed clinical review of a relatively large number of sighted patients with non-24-hour sleep-wake syndrome. more...
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- 2005
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17. Melatonin, cortisol and thyroid-stimulating hormone rhythms are delayed in patients with delayed sleep phase syndrome
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Tatsuro Hayakawa, Hiroyuki Suzuki, Kayo Shibui, Kiyohisa Takahashi, Masako Okawa, Yuichi Kamei, Kenichi Kuriyama, Hirokuni Tagaya, Keiko Kim, and Makoto Uchiyama
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medicine.medical_specialty ,Physiology ,Circadian clock ,Delayed sleep phase ,Biology ,medicine.disease ,Melatonin ,Neuropsychology and Physiological Psychology ,Endocrinology ,Neurology ,Dark therapy ,Physiology (medical) ,Internal medicine ,Insomnia ,medicine ,Free-running sleep ,Circadian rhythm ,medicine.symptom ,Sleep onset ,medicine.drug - Abstract
Delayed sleep phase syndrome (DSPS) is a chronic sleep onset insomnia that is caused by a persistent delay of sleep timing. Functional abnormalities of the circadian pacemaker have been assumed to underlie this syndrome, but its detailed pathophysiology has not yet been identified. We studied nine patients with DSPS and 20 healthy controls to compare habitual sleep timings and hormonal rhythms between the groups. Concentrations of serum melatonin, cortisol, and thyroid-stimulating hormone (TSH) were assessed every hour for 26 h under dim light condition. The hormonal rhythms were significantly delayed in patients with DSPS compared with controls, whereas the 24-h amounts of hormonal secretions and the phase relationships between the hormonal rhythms did not differ between the groups. We postulate that sleep-phase delay in patients with DSPS is a consequence of the phase delay of the circadian pacemaker, therefore, suggesting that phase delay in the circadian clock is responsible for this disorder. more...
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- 2003
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18. Increased Silent Brain Infarction Accompanied With High Prevalence of Diabetes and Dyslipidemia in Psychiatric Inpatients
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Kazuei Igarashi, Keisuke Sekine, Kazumi Tsukada, Yoriyasu Uju, Tetsuya Hisaoka, Masafumi Miura, Tatsuro Hayakawa, Asuka Yasukawa, Mamoru Sato, Yukihiro Ishii, Chieko Nakano, Tsuyoshi Takizawa, Shunichi Mishima, Taro Yoshimi, Seiko Okamoto, Seisuke Mimori, Tetsuto Kanzaki, Kanako Murakami, Yasuhiko Mizuta, Reiko Yasui, and Shun Kusanishi more...
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medicine.medical_specialty ,High prevalence ,Cross-sectional study ,business.industry ,Articles ,General Medicine ,medicine.disease ,Brain infarction ,Schizophrenia ,Diabetes mellitus ,medicine ,business ,Psychiatry ,Stroke ,Dyslipidemia ,Cause of death - Abstract
Patients with schizophrenia have increased risk of atherosclerotic diseases. It is already known that lifestyle-related disorders and the use of antipsychotics are closely related with the progression of atherosclerosis in psychiatric patients. Stroke as well as coronary heart disease play an important role in the cause of death in Asia and Japan. Thus, we studied the prevalence of cerebrovascular disease in psychiatric inpatients in Japan using brain magnetic resonance imaging (MRI).This cross-sectional study was performed from January 2012 to December 2013. Study participants were 152 hospitalized patients (61 men and 91 women) in the Department of Psychiatry at Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa City, Japan. Mean ages were 50.0 and 57.1 years old for men and women, respectively. The diagnoses (DSM-IV-TR criteria) of participants were schizophrenia (69.1%), mood disorder (18.4%), and other mental disorders (12.5%). We checked physical status, metabolic status of glucose and lipid levels, and brain MRI within 1 week of admission.The study group showed a significantly high prevalence of diabetes and low high-density lipoprotein (HDL) cholesterolemia in both sexes (n = 61 in men, n = 91 in women, P.05). In the study group, serum fasting plasma glucose and hemoglobin A1c levels were significantly high (n = 152, P.05), but serum HDL cholesterol and total cholesterol were significantly low in both sexes (n = 61 in men, n = 90 in women, P.05), and triglycerides were low in men (n = 61, P.05). Silent brain infarction was recognized at a higher rate (n = 98, P.05) compared with healthy controls.Participants in this study had an increased ratio of silent brain infarction compared with Japanese healthy controls, accompanied with higher ratios of diabetes and low HDL cholesterol. more...
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- 2015
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19. Diurnal fluctuation of sleep propensity and hormonal secretion across the menstrual cycle
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Tatsuro Hayakawa, Kenichi Ishibashi, Katsuya Ohta, Tatsuya Akamatsu, Keiko Kim, Xianchen Liu, Yoshihisa Kudo, Kayo Shibui, Yuichi Kamei, Masako Okawa, and Makoto Uchiyama
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Adult ,endocrine system ,medicine.medical_specialty ,Hydrocortisone ,Polysomnography ,media_common.quotation_subject ,Thyrotropin ,Luteal Phase ,Luteal phase ,Biology ,Body Temperature ,Melatonin ,Internal medicine ,Follicular phase ,medicine ,Humans ,Circadian rhythm ,Menstrual Cycle ,Progesterone ,Biological Psychiatry ,Menstrual cycle ,media_common ,Slow-wave sleep ,Analysis of Variance ,Chronobiology ,Cross-Over Studies ,Estradiol ,medicine.diagnostic_test ,Circadian Rhythm ,Endocrinology ,Follicular Phase ,Female ,Sleep ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Background: The fact that most women experience sleep changes across the menstrual cycle is thought to be associated with changes in circadian rhythms; however, few studies have investigated this relationship. Methods: We applied an ultrashort sleep–wake schedule to eight healthy women and studied diurnal fluctuations in sleep propensity, sleepiness, rectal temperature, and serum concentrations of melatonin, thyroid-stimulating hormone, and cortisol in the follicular and luteal phases. Results: In the luteal phase, amplitude of core body temperature, total melatonin secretions, and amplitudes of TSH and cortisol rhythms were significantly decreased, whereas sleepiness and occurrence of slow-wave sleep during the daytime were significantly increased. Differences in the amount of daytime slow-wave sleep across the menstrual cycle were positively correlated with differences in the daily mean rectal temperature. Conclusions: The findings suggest that the amplitude of circadian oscillation may be dampened in the luteal phase. Increased daytime sleepiness in the luteal phase may be associated with increased daytime slow-wave sleep, due possibly to changes in thermoregulation in the luteal phase. more...
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- 2000
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20. Altered phase relation between sleep timing and core body temperature rhythm in delayed sleep phase syndrome and non-24-hour sleep–wake syndrome in humans
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Yoshihisa Kudo, Tatsuro Hayakawa, Kiyohisa Takahashi, Kayo Shibui, Jujiro Urata, Keiko Kim, Yuichi Kamei, Masako Okawa, Hirokuni Tagaya, and Makoto Uchiyama
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Adult ,Male ,Periodicity ,Sleep disorder ,General Neuroscience ,Delayed sleep phase ,medicine.disease ,Body Temperature ,Circadian Rhythm ,Temperature rhythm ,Biological Clocks ,Sleep Disorders, Circadian Rhythm ,Anesthesia ,medicine ,Humans ,Phase relation ,Free-running sleep ,Female ,Circadian rhythm ,Sleep onset ,Psychology ,Slow-wave sleep - Abstract
Changes in the phase relation between sleep timing and the circadian pacemaker are suspected to have an etiological significance in circadian rhythm sleep disorders. Simultaneous recordings of rest-activity and rectal temperature in seven sighted delayed sleep phase syndrome (DSPS) patients, seven sighted non-24-h sleep-wake syndrome (non-24) patients, and 14 healthy controls were made for 10-14 days continuously in the subjects' homes. We found that sleep length and the interval from the body temperature (BT) trough to sleep offset were significantly longer in both non-24 and DSPS patients than in the controls, and that the interval between sleep onset and the BT trough was significantly less in the non-24 patients than in the DSPS patients and the controls. We postulate these alterations in phase relation to be associated with phase changes of the circadian pacemaker via different illumination timings. more...
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- 2000
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21. Poor Compensatory Function for Sleep Loss as a Pathogenic Factor in Patients with Delayed Sleep Phase Syndrome
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Xianchen Liu, Kiyohisa Takahashi, Tatsuro Hayakawa, Yuichi Kamei, Masako Okawa, Kayo Shibui, and Makoto Uchiyama
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Delayed sleep phase ,Audiology ,Severity of Illness Index ,Non-rapid eye movement sleep ,Body Temperature ,Melatonin ,Dark therapy ,Sleep Disorders, Circadian Rhythm ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Free-running sleep ,Circadian rhythm ,Sleep disorder ,medicine.disease ,Sleep deprivation ,Endocrinology ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,medicine.drug - Abstract
Objective Delayed sleep phase syndrome (DSPS) is a condition in which the patient is unable to reset or phase-advance his/her sleep timing properly after transient sleep delay and consequently shows persistent sleep phase delay. Prior studies suggested that DSPS is associated with a phase delay in the circadian pacemaker, but there was no evidence to explain the patient's inability to reset sleep phase. Subjects and methods We used an ultra-short sleep-wake schedule together with simultaneous measurement of dim light melatonin rhythm after 24-hour sleep deprivation to allow the differential observation of diurnal sleep propensity fluctuation both from circadian and homeostatic aspects in 11 patients with DSPS (17-37 years; 8 men, 3 women) and 15 healthy controls (19-32 years; 8 men, 7 women). Setting NA. Patients or participants NA. Interventions NA. Results DSPS patients showed less ability to compensate for previous sleep loss during their circadian day and first hours of their circadian nighttime determined by dim light melatonin onset compared with controls, while controls compensated for previous sleep loss at most circadian times. Though shapes of dim light melatonin rhythm did not differ between the groups, phase angle between melatonin and sleep propensity rhythms was wider in DSPS patients than in controls. Conclusions These findings suggest that poor compensatory function for sleep loss predisposes DSPS patients to failure to reset their sleep phase. Our results provide implications for understanding not only the pathophysiology of DSPS but also the biological basis for why some people can change their sleep schedule easily according to personal or social demands while others cannot. more...
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- 2000
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22. [Clinical experience with clozapine in 55 cases of treatment-resistant schizophrenia]
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Tetsuro, Enomoto, Toshihiko, Ito, Keisuke, Sekine, Reiko, Yasui, Yuko, Ashizawa, Yoriyasu, Uju, Tatsuro, Hayakawa, and Kazumi, Tsukada
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Adult ,Male ,Young Adult ,Treatment Outcome ,Schizophrenia ,Brief Psychiatric Rating Scale ,Humans ,Female ,Middle Aged ,Clozapine ,Aged ,Antipsychotic Agents ,Follow-Up Studies - Abstract
Up until October 2012, Kohnodai Hospital had introduced clozapine treatment for 55 cases of treatment-resistant schizophrenia. In all cases, previous antipsychotic medication was discontinued the day before clozapine administration began. Of the 55 cases, 45(85%)are continuing clozapine administration, and 40 cases (73%) are receiving outpatient treatment. The average dose of clozapine was 373.1 mg/day (SD : 160.5). Clozapine was administered for a month or more in 51 cases (93%). BPRS scores improved 20% or more in a month's administration of clozapine in 18 of the cases (35%). The average clozapine dose in the improvement cases was 176 mg/day. The average BPRS score had significantly decreased from the baseline at months 1, 3, 6, and 12 after the start of clozapine administration. Of the 33 cases receiving clozapine treatment for 12 months or more, BPRS improved 20% or more in 27 (82%). BPRS improved 20% or more for the first time after clozapine administration within a month in 12 cases (44%), 3 months in 8 cases (30%), 6 months in 5 cases (19%), and 12 months in 2 cases (7%). These results suggest that clozapine should be administered continuously for over 6 months at the least and 12 months if possible to evaluate the efficacy of clozapine treatment. Of the 43 cases receiving outpatient clozapine therapy, the average GAF score improved significantly from the time of ward admission to discharge (20.6 and 42.0, respectively). Clozapine had to be discontinued in 2 cases of leukopenia, 2 cases of neutropenia, 1 case of reduced left ventricular ejection due to pericardial effusion, 1 case of drug eruption, and 1 case of marked hunger. When introducing clozapine for treatment-resistant schizophrenia, it is important to administer it as a monotherapy, slowly increase the dosage to reduce side effects, and achieve a treatment effect at the minimum required dosage. more...
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- 2013
23. Development of diabetes mellitus associated with quetiapine
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Yoriyasu Uju, Tetsuro Enomoto, Hideki Nanasawa, Tatsuro Hayakawa, Toshihiko Ito, Hidekatsu Yanai, Kaori Nonogaki, Akahito Sako, Tadayuki Kondo, Shuichi Mishima, and Tomohiko Mitsutsuka
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,antipsychotic drugs ,Observational Study ,Quetiapine Fumarate ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Internal medicine ,Diabetes mellitus ,Humans ,Medicine ,Aged ,Retrospective Studies ,Mood Disorders ,business.industry ,Insulin ,dyslipidemia ,General Medicine ,Middle Aged ,quetiapine ,medicine.disease ,030227 psychiatry ,Discontinuation ,schizophrenia ,diabetes mellitus ,Quetiapine ,Female ,business ,Body mass index ,030217 neurology & neurosurgery ,Dyslipidemia ,Antipsychotic Agents ,Research Article ,medicine.drug - Abstract
We aimed to describe the characteristics and clinical course of patients who developed diabetes associated with the use of quetiapine. This study included patients who received quetiapine for over a month between April 2008 and November 2013, and were diagnosed as having new-onset diabetes after initiation of quetiapine. We excluded patients who developed diabetes more than 1 year after discontinuation of quetiapine. We identified new-onset diabetes by hemoglobin A1c or prescriptions of antidiabetic drugs. Among 1688 patients who received quetiapine, hemoglobin A1c had been measured in 595 (35.2%) patients at least once during the observation period, and 33 (2.0%) patients had received hypoglycemic drugs. Eighteen (1.1%) patients were considered to have developed new-onset diabetes associated with quetiapine after a median of 1.6 years following initiation of quetiapine. Median (interquartile range) age was 54.5 (29.8) years, 8 patients were male, and median (interquartile range) duration of mental illness was 15.3 (13.8) years. Median hemoglobin A1c and body mass index (BMI) were 7.1 (1.4) % and 28.4 (7.0) kg/m2, respectively. Seventeen patients had dyslipidemia when diabetes was discovered. All of these discontinued quetiapine within 3 months after the diagnosis of diabetes, and the diabetes in 4 patients had ameliorated without hypoglycemic drugs. Of 13 patients who had received either oral hypoglycemic drugs or insulin, 2 patients achieved well-controlled hemoglobin A1c without hypoglycemic drugs, and 10 patients had hemoglobin A1c 5.0% to 7.7% with the continued use of hypoglycemic drugs. We demonstrated that almost all patients who developed quetiapine-associated diabetes had dyslipidemia and increased BMI. There was no life-threatening hyperglycemia and diabetes was ameliorated just by discontinuation of quetiapine in several patients. The monitoring of metabolic parameters during antipsychotic treatment is important to diagnose and treat diabetes earlier. more...
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- 2017
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24. The effect of mental disorders on glycemic control of patients with type 2 diabetes
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Tetsuro Enomoto, Tatsuro Hayakawa, Toshihiko Ito, Hidetaka Hamasaki, Akahito Sako, Yoriyasu Uju, Yu Takeuchi, Tadayuki Kondo, Hisayuki Katsuyama, and Hidekatsu Yanai
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medicine.medical_specialty ,Endocrinology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,General Medicine ,Type 2 diabetes ,medicine.disease ,business ,Glycemic - Published
- 2016
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25. A significant association between physical restraint and the development of venous thromboembolism in psychiatric patients
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Naonori Tsuda, Akahito Sako, Kazumi Tsukada, Tatsuro Hayakawa, Seiko Okamoto, Hidekatsu Yanai, Kazunori Makino, and Hiroki Adachi
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Male ,Restraint, Physical ,medicine.medical_specialty ,Inferior vena cava ,medicine ,Humans ,In patient ,cardiovascular diseases ,Vein ,Psychiatry ,Aged ,Aged, 80 and over ,business.industry ,Incidence (epidemiology) ,Medical record ,Mental Disorders ,Venous Thromboembolism ,Middle Aged ,equipment and supplies ,medicine.disease ,Thrombosis ,Stenosis ,medicine.anatomical_structure ,medicine.vein ,Female ,Cardiology and Cardiovascular Medicine ,business ,Venous thromboembolism - Abstract
Recently, the systematic review about venous thromboembolism (VTE) prophylaxis in hospitalized adult nonsurgical patients has been reported [1], bringing lively and controversial discussions. The prophylaxis of VTE is a very important subject for also hospitalized psychiatric patients. We have certified that we comply with the Principles of Ethical Publishing in the International Journal of Cardiology [2]. To elucidate the risk factors for the development of VTE in hospitalized psychiatric patients, we analyzed patients who developed VTE which was confirmed by ultrasound and/or contrast enhanced computed tomography during recent five years (from April 2007 to September 2011) in our hospital, using the inpatient medical records. We studied age, sex, and frequency of the existence of reported risk factors for VTE [3] and physical restraint in VTE patients with and without psychiatric diseases. We detected 48 VTE patients. There were 31 patients with psychiatric diseases and 17 patients without psychiatric diseases. The differences in age, sex, and frequency of the existence of reported risk factors for VTE and physical restraint in VTE patients with and without psychiatric diseases were shown in Table 1 [3]. Age of VTE patients with psychiatric diseases was significantly lower than that of VTE patients without psychiatric diseases. There were no significant differences in frequency of reported risk factors for VTE between patients with and without psychiatric diseases. The frequencyof physical restraintwas significantly higher in VTE patients with psychiatric diseases than patients without psychiatric diseases. A number of studies have suggested a significant association between increasing age and elevated incidence of VTE [3]. Risk for VTE approximately doubles with each subsequent decade. In our study, VTE patients with psychiatric diseases were significantly younger than VTE patients without psychiatric diseases, suggesting that an association between aging and the development of VTE is weaker in patients with psychiatric diseases than patients without psychiatric diseases. Present study demonstrated a significantly higher frequency of physical restraint in patients with psychiatric diseases as compared with patients without psychiatric diseases, indicating a significant association between physical restraint and the development of VTE in psychiatric patients. Virchow R proposed that thrombosis was the result of at least 1 of 3 underlying etiologic factors: vascular endothelial damage, stasis of blood flow, and hypercoagulability. According to his description, there has been interest in the development of animal models of thrombosis to mimic the human condition. Therefore, the inferior vena cava (IVC) ligationmodel and the IVC stenosis model have been developed as the mouse models of VTE [4]. Studies in the IVC ligation rats suggest that after IVC ligation a combination of stasisinduced vein wall injury and enhanced tissue factor expression in endothelial cells and leukocytes produce thrombosis, and the IVC stenosis model combined external compression with a reduction in blood flow to produce laminar thrombosis [5,6]. Physical restraint may induce external compression and a reduction in blood flow of vein, and also a stasis-induced vein wall injury and enhanced tissue factor expression in endothelial cells, resulting in thrombosis formation. Physical restraint also leads to immobility strongly associated with the development of VTE [3]. In conclusion, physical restraint is significantly associated with the development of VTE in psychiatric patients. more...
- Published
- 2012
26. Difference in early prediction of antipsychotic non-response between risperidone and olanzapine in the treatment of acute-phase schizophrenia
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Hiroshi Hamakawa, Yuko Ashizawa, Yutaka Sawa, Yasuhiko Sudo, Hiroshi Takebayashi, Chie Usui, Kotaro Hatta, Naoki Hayashi, Taro Otachi, Shin Ito, Tatsuro Hayakawa, Reiko Nakase, Hiroyuki Nakamura, and Toyoaki Hirata more...
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Olanzapine ,Adult ,Male ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Atypical antipsychotic ,Sensitivity and Specificity ,law.invention ,Benzodiazepines ,Randomized controlled trial ,Japan ,law ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Antipsychotic ,Psychiatry ,Biological Psychiatry ,Psychiatric Status Rating Scales ,Analysis of Variance ,Risperidone ,Positive and Negative Syndrome Scale ,Dose-Response Relationship, Drug ,Dopamine antagonist ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Schizophrenia ,Female ,Psychology ,medicine.drug ,Antipsychotic Agents ,Follow-Up Studies - Abstract
We examined whether early response/non-response to risperidone according to the Clinical Global Impressions-improvement scale (CGI-I) at 2 weeks could predict subsequent response. This prediction was also applied to olanzapine. We then investigated whether early non-responders (ENRs) to risperidone or olanzapine who switched to the other showed significantly greater improvement, compared with those staying on the initial antipsychotic. We performed a rater-blinded, randomized controlled trial in 18 psychiatric emergency sites. Eligible patients were newly admitted patients with acute schizophrenia. Early response was defined as CGI-I ≤ 3 following 2 weeks of treatment. The primary outcome measure was achievement of remission and ≥ 50% improvement in the Positive and Negative Syndrome Scale at 4 weeks.At 4 weeks, 53% of risperidone early responders (ERs) went into remission, whereas only 9% of ENRs staying on risperidone (n=11) did (P=0.016). Similarly, at 4 weeks, 81% of risperidone ERs achieved ≥ 50% response, whereas only 9% of ENRs staying on risperidone achieved ≥ 50% response (P0.0001). In contrast, 58% of olanzapine ERs (n=33) went into remission, whereas 38% of ENRs staying on olanzapine (n=8) did at 4 weeks (P=0.44). Similarly, 61% of olanzapine ERs achieved ≥ 50% response, whereas 25% of ENRs staying on olanzapine achieved ≥ 50% response (P=0.12). The negative likelihood ratio for the prediction of ≥ 50% response at 4 weeks by early response status to risperidone at 2 weeks was 0.057.In newly admitted patients with acute schizophrenia, non-response to risperidone using CGI-I at 2 weeks can predict subsequent response. It looks like there is significant response to olanzapine that doesn't occur until 4 weeks. Thus, clinicians may want to switch to another drug earlier when risperidone is the first drug, and later when olanzapine is the first drug. more...
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- 2010
27. Diurnal fluctuation of sleep propensity across the menstrual cycle
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Masako Okawa, Yuichi Kamei, Tatsuya Akamatsu, Kayo Shibui, Keiko Kim, Tatsuro Hayakawa, Yoshihisa Kudo, Kenichi Ishibashi, Makoto Uchiyama, and Katsuya Ohta
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Adult ,endocrine system ,medicine.medical_specialty ,Polysomnography ,media_common.quotation_subject ,Luteal Phase ,Luteal phase ,Rhythm ,Internal medicine ,Follicular phase ,Humans ,Medicine ,Wakefulness ,Menstrual Cycle ,Menstrual cycle ,Slow-wave sleep ,media_common ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Brain ,General Medicine ,Sleep in non-human animals ,Circadian Rhythm ,Nap ,Psychiatry and Mental health ,Endocrinology ,Follicular Phase ,Neurology ,Female ,Sleep Stages ,Neurology (clinical) ,Arousal ,business - Abstract
Most women experience sleep changes across the menstrual cycle. We applied the ultra-short sleep-wake schedule to healthy females to compare their 24-h sleep propensity rhythms in the follicular and luteal phases. The daytime (09.00-16.30 h) subjective sleepiness and the number of slow wave sleep-containing nap trials increased in the luteal phase compared to the follicular phase, but the mean sleep propensity did not change. During the periods of 17.00-00.30 h and 01.00-08.30 h there were no differences between the two phases. These results suggest that increased daytime sleepiness in the luteal phase may be related to brain mechanisms controlling slow wave sleep. more...
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- 1999
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28. Poor recovery sleep after sleep deprivation in delayed sleep phase syndrome
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Tatsuro Hayakawa, Masako Okawa, Yuichi Kamei, Yosihisa Kudo, Jujiro Urata, Kayo Shibui, Makoto Uchiyama, and Keiko Kim
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Adult ,Male ,Sleep Wake Disorders ,Sleep, REM ,Delayed sleep phase ,Non-rapid eye movement sleep ,Sleep debt ,Reference Values ,Homeostasis ,Humans ,Medicine ,Free-running sleep ,Melatonin ,Slow-wave sleep ,Sleep disorder ,business.industry ,General Neuroscience ,Chronotype ,Syndrome ,General Medicine ,medicine.disease ,Circadian Rhythm ,Psychiatry and Mental health ,Sleep deprivation ,Neurology ,Anesthesia ,Sleep Deprivation ,Sleep Stages ,Neurology (clinical) ,medicine.symptom ,business - Abstract
To clarify disturbances in sleep regulation in patients with delayed sleep phase syndrome (DSPS), we studied three patients with DSPS and seven healthy controls. Sleep propensity and melatonin rhythms after 24-h sleep deprivation were investigated under dim light condition by using the ultra-short sleep-wake schedule. The sleep propensity curves displayed clear differences between DSPS patients and the controls. During the subjective day when melatonin was not produced, recovery sleep after the sleep deprivation did not occur in DSPS patients, while recovery sleep occurred during the subjective day in controls. This suggests that DSPS may involve problems related to the homeostatic regulation of sleep after sleep deprivation. more...
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- 1999
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29. Correlation between the circadian sleep propensity rhythm and hormonal rhythms under ultra‐short sleep–wake cycle
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Yuichi Kamei, Tatsuro Hayakawa, Kayo Shibui, Kenichi Ishibashi, Keiko Kim, Makoto Uchiyama, Yoshihisa Kudo, and Masako Okawa
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Adult ,endocrine system ,medicine.medical_specialty ,Hydrocortisone ,Thyrotropin ,Melatonin ,Habits ,Rhythm ,Dark therapy ,Internal medicine ,medicine ,Humans ,Free-running sleep ,Circadian rhythm ,Wakefulness ,business.industry ,General Neuroscience ,Chronotype ,General Medicine ,Circadian Rhythm ,Psychiatry and Mental health ,Sleep deprivation ,Endocrinology ,Neurology ,Infradian rhythm ,Sleep Deprivation ,Female ,Sleep Stages ,Neurology (clinical) ,medicine.symptom ,business ,hormones, hormone substitutes, and hormone antagonists ,Body Temperature Regulation ,medicine.drug - Abstract
The aim of this study was to clarify effects of hormonal and temperature rhythms on circadian fluctuations of sleep propensity. Ten healthy females underwent 24-h sleep deprivation and entered the circadian sleep propensity assessment setting under the ultra-short sleep–wake schedule. During the experiment, sleep propensity rhythm, rectal temperature, and 24-h serum hormone profiles (melatonin, cortisol and thyroid-stimulating hormone) were investigated. The circadian sleep propensity rhythms had two apparent peaks (afternoon and nocturnal peaks) and a trough (nocturnal sleep gate). The timings of the nocturnal sleep gate and the nocturnal peak were correlated exclusively with temperature and melatonin rhythms (P < 0.05), while that of the afternoon peak was significantly correlated with habitual wake time and melatonin rhythm. These results indicate that the circadian sleep propensity rhythm is influenced not only by the circadian pacemaker, but also by sleep habit. more...
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- 1999
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30. Larger phase angle between sleep propensity and melatonin rhythms in sighted humans with non-24-hour sleep-wake syndrome
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Tatsuro Hayakawa, Kiyohisa Takahashi, Takashi Ebisawa, Hirokuni Tagaya, Kayo Shibui, Masako Okawa, Yuichi Kamei, and Makoto Uchiyama
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Period (gene) ,Polysomnography ,law.invention ,Melatonin ,Rhythm ,law ,Sleep Disorders, Circadian Rhythm ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Circadian rhythm ,Phase angle ,Sleep in non-human animals ,Circadian Rhythm ,Sleep deprivation ,Endocrinology ,Anesthesia ,Case-Control Studies ,Artificial cardiac pacemaker ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,medicine.drug - Abstract
Study objectives: This study was aimed to clarify phase angle between sleep propensity and the circadian pacemaker in patients with non-24hour sleep-wake syndrome (Non-24). Design and Setting: A case-control study was undertaken. Participants: Sighted patient with Non-24 (4 males and 1 female, aged 16 to 39 y), and sex- and age-matched healthy controls (12 males and 3 females, aged 19 to 35 y) participated the study. Measurement and Intervention: Following an actigraphic assessment of the sleep–wake cycle in their homes, the participants entered an ultrashort sleep-wake schedule together with simultaneous measurement of dim light melatonin rhythm after 24-hour sleep deprivation. Results: The period of the sleep-wake cycle observed at home was longer in the Non-24 patients (25.12 hours) than in the controls (24.02 hours, p more...
- Published
- 2002
31. Effects of small dose of brotizolam on P300
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Tetsuro Enomoto, Shigeru Ozaki, Tatsuro Hayakawa, Yoshihisa Kudo, Tsuneo Nakajima, Masako Okawa, Keiko Kim, Kayo Shibui, Toru Nakajima, Makoto Uchiyama, Hiroyuki Suzuki, and Jujiro Urata
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Adult ,Male ,Triazolam ,medicine.drug_class ,Placebo ,Hypnotic ,Double-Blind Method ,medicine ,Humans ,Hypnotics and Sedatives ,Oddball paradigm ,Morning ,Cerebral Cortex ,Cross-Over Studies ,Dose-Response Relationship, Drug ,General Neuroscience ,Brotizolam ,Electroencephalography ,General Medicine ,Azepines ,Crossover study ,Event-Related Potentials, P300 ,Psychiatry and Mental health ,Neurology ,Anesthesia ,Sedative ,Neurology (clinical) ,Psychology ,medicine.drug - Abstract
Nine healthy men (mean age, 22.2 years) participated in two experimental sessions cross-overed randomly in a double blind manner; one with a placebo and the other with 0.125 mg of brotizolam (BTZ) administered in the morning. Resting electroencephalogram and event-related potential under oddball paradigm was recorded before and 1, 2, 4, 6 and 8 h after the administration. Mean 30-msec bin amplitude from 240 msec to 450 msec after the stimulus was compared between placebo and drug sessions in order to observe P300. Brotizolam reduced the amplitude of P300 at 6 h after administration. It was noted that the effects of BTZ were most marked at Fz. more...
- Published
- 2001
32. Melatonin treatment for circadian rhythm sleep disorders
- Author
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Yoshihisa Kudo, Tatsuro Hayakawa, Yuichi Kamei, Masako Okawa, Kayo Shibui, Makoto Uchiyama, Keiko Kim, and Jujiro Urata
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Polysomnography ,Administration, Oral ,Delayed sleep phase ,Bedtime ,Drug Administration Schedule ,Hypnotic ,Melatonin ,Dark therapy ,Sleep Disorders, Circadian Rhythm ,Internal medicine ,medicine ,Humans ,Circadian rhythm ,Sleep disorder ,medicine.diagnostic_test ,Dose-Response Relationship, Drug ,General Neuroscience ,General Medicine ,medicine.disease ,Psychiatry and Mental health ,Endocrinology ,Treatment Outcome ,Neurology ,Female ,Neurology (clinical) ,Psychology ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
We administered 1-3 mg melatonin to 11 patients (eight men, three women, aged 16-46 years) with circadian rhythm sleep disorders; nine with delayed sleep phase syndrome and two with non-24-hour sleep-wake syndrome. Sleep logs were recorded throughout the study periods and actigraph and rectal temperature were monitored during treatment periods. Melatonin was administered 1-2 h before the desirable bedtime for expected phase-shifting, or 0.5-1 h before habitual bedtime for gradual advance expecting an hypnotic effect of the melatonin. Melatonin treatments were successful in 6/11 patients. Timing and dose of melatonin administration, together with its pharmacological properties for circadian rhythm sleep disorders, should be further studied. more...
- Published
- 2001
33. Effects of a small dose of triazolam on P300
- Author
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Jujiro Urata, Masako Okawa, Tatsuro Hayakawa, Tetsuro Enomoto, Junji Okubo, and Makoto Uchiyama
- Subjects
Adult ,Male ,Triazolam ,Sedation ,Electroencephalography ,Placebo ,Cognition ,Double-Blind Method ,Event-related potential ,medicine ,Humans ,Hypnotics and Sedatives ,Attention ,Oddball paradigm ,Cross-Over Studies ,medicine.diagnostic_test ,Dose-Response Relationship, Drug ,General Neuroscience ,General Medicine ,Crossover study ,Event-Related Potentials, P300 ,Psychiatry and Mental health ,Dose–response relationship ,Neurology ,Anesthesia ,Neurology (clinical) ,medicine.symptom ,Psychology ,Arousal ,medicine.drug - Abstract
Ten healthy men (mean age, 33.9 years) participated in two experimental sessions cross-overed randomly in a double-blind manner: one with the placebo and another with 0.125 mg of triazolam (TRZ). Resting electroencephalography and event-related potential under oddball paradigm were recorded before the drug administration, and 1, 2, 4, 6 and 8 h after that. P300 waveforms were analyzed by peak amplitudes and 30-ms bin data. Triazolam may cause cognitive dysfunction without general sedation or apparent sleepiness, and this effect appeared 2 h, 4 h and 6 h, most prominently 6 h, after TRZ administration. more...
- Published
- 1999
34. Clinical characteristics of circadian rhythm sleep disorders
- Author
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Tatsuro Hayakawa, Masako Okawa, Yuichi Kamei, Shigeru Ozaki, Kayo Shibui, Makoto Uchiyaya, and Jujiro Urata
- Subjects
Adult ,Male ,Sleep Wake Disorders ,medicine.medical_specialty ,Neurology ,Delayed sleep phase ,Diagnosis, Differential ,Rhythm ,Dark therapy ,medicine ,Humans ,Circadian rhythm ,Wakefulness ,Psychiatry ,Somatoform Disorders ,Retrospective Studies ,Sleep disorder ,business.industry ,Depression ,General Neuroscience ,Chronotype ,General Medicine ,medicine.disease ,Sleep in non-human animals ,Circadian Rhythm ,Psychiatry and Mental health ,Female ,Neurology (clinical) ,business ,Social Adjustment - Abstract
From our practice at the sleep disorders clinic in Kohnodai Hospital, National Center of Neurology and Psychiatry (NCNP), we report the clinical characteristics of circadian sleep-wake rhythm disorders. Nearly 90% of circadian rhythm sleep disorders were diagnosed as delayed sleep phase syndrome (DSPS) or as non-24 sleep-wake syndrome (non-24). While DSPS was equally common in males and females, non-24 was more frequently seen in men. It was of psychiatric interest that a considerable number of patients had depressive states in the course of their circadian rhythm sleep disorders. Difficulty in adapting to social life was more severe in patients with non-24 than in those with DSPS. more...
- Published
- 1998
35. Development of diabetes mellitus associated with quetiapine: A case series.
- Author
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Hideki Nanasawa, Akahito Sako, Tomohiko Mitsutsuka, Kaori Nonogaki, Tadayuki Kondo, Shuichi Mishima, Yoriyasu Uju, Toshihiko Ito, Tetsuro Enomoto, Tatsuro Hayakawa, Hidekatsu Yanai, Nanasawa, Hideki, Sako, Akahito, Mitsutsuka, Tomohiko, Nonogaki, Kaori, Kondo, Tadayuki, Mishima, Shuichi, Uju, Yoriyasu, Ito, Toshihiko, and Enomoto, Tetsuro more...
- Published
- 2017
- Full Text
- View/download PDF
36. Validity and reliability of Structured Interview for Competency Incompetency Assessment Testing and Ranking Inventory
- Author
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Tatsuro Hayakawa, Fusako Kitamura, Atsuko Tomoda, Kazumi Tsukada, Toshinori Kitamura, Rie Yasumiya, Takahiro Sumiyama, and Kimimori Matsubara
- Subjects
Adult ,Male ,medicine.medical_specialty ,Psychometrics ,Personality Inventory ,Concurrent validity ,Judgement ,Validity ,Test validity ,Sensitivity and Specificity ,Arts and Humanities (miscellaneous) ,Informed consent ,medicine ,Humans ,Mental Competency ,Aged ,Psychiatric Status Rating Scales ,Informed Consent ,Mental Disorders ,Reproducibility of Results ,Middle Aged ,Patient Acceptance of Health Care ,Hospitalization ,Clinical Psychology ,Convergent validity ,Family medicine ,Structured interview ,Female ,Psychology ,Clinical psychology - Abstract
The Structured Interview for Competency and Incompetency Assessment Testing and Ranking Inventory (SICIATRI) is a structured interview guide to assess the competency for giving informed consent to treatment among psychiatric and medical patients. The competency levels of 48 psychiatric and medical inpatients were assessed by SICIATRI. A relatively high- inter-rater reliability of the SICIATRI items (over half of the items had kappa > or = .60) and concurrent validity (sensitivity = .83, specificity = .67 as measured against the global judgement of competency rating by the attending physician) were obtained. In addition to its brevity (it takes about 20 minutes to complete), these findings may warrant application of this instrument in a clinical setting. more...
- Published
- 1997
37. The Relationship between Sleep—Wake Rhythm and Body Temperature Rhythm in Delayed Sleep Phase Syndrome and Non-24-Hour Sleep—Wake Rhythm
- Author
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Masako Okawa, Makoto Uchiyama, Shigeru Ozaki, Yuichi Kamei, Tatsuro Hayakawa, and Jujiro Urata
- Published
- 1997
- Full Text
- View/download PDF
38. Trials of bright light exposure and melatonin administration in a patient with non-24 hour sleep-wake syndrome
- Author
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Tatsuro Hayakawa, Jujiro Urata, Masako Okawa, Makoto Uchiyama, Yuichi Kamei, Shigeru Ozaki, and Kayo Shibui
- Subjects
Adult ,Male ,Sleep Wake Disorders ,Evening ,genetic structures ,Melatonin ,Humans ,Medicine ,Circadian rhythm ,Wakefulness ,Morning ,Sleep Stages ,Bright light therapy ,business.industry ,General Neuroscience ,General Medicine ,Phototherapy ,Combined Modality Therapy ,Circadian Rhythm ,Psychiatry and Mental health ,Treatment Outcome ,Neurology ,Anesthesia ,Hour sleep ,sense organs ,Neurology (clinical) ,business ,hormones, hormone substitutes, and hormone antagonists ,Bright light ,medicine.drug - Abstract
We report a patient with non-24 h sleep-wake syndrome (non-24) whose free-running sleep-wake cycle was successfully treated with both scheduled bright light exposure and melatonin treatment. In the present study, morning bright light as well as evening melatonin phase-advanced sleep-wake cycles and melatonin rhythm. Both these procedures achieved appropriate entrainment to a 24 h day. However, the patient did not continue morning bright light therapy after the discharge. Rising at appropriate times in the morning for bright light therapy was difficult for him to continue. Melatonin treatment was better tolerated because of its ease of application. more...
- Published
- 1998
- Full Text
- View/download PDF
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