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15 results on '"Taube, Eliane Tabea"'

2. Human leucocyte antigen class I in hormone receptor-positive, HER2-negative breast cancer: association with response and survival after neoadjuvant chemotherapy

Author

Sinn, Bruno Valentin, Weber, Karsten E., Schmitt, Wolfgang Daniel, Fasching, Peter A., Symmans, William Fraser, Blohmer, Jens-Uwe, Karn, Thomas, Taube, Eliane Tabea, Klauschen, Frederick, Marmé, Frederik, Schem, Christian, Stickeler, Elmar, Ataseven, Beyhan, Huober, Jens, von Minckwitz, Gunter, Seliger, Barbara, Denkert, Carsten, and Loibl, Sibylle

Published
2019
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4. Low Expression of RGS2 Promotes Poor Prognosis in High-Grade Serous Ovarian Cancer

Author

Ihlow, Jana, primary, Monjé, Nanna, additional, Hoffmann, Inga, additional, Bischoff, Philip, additional, Sinn, Bruno Valentin, additional, Schmitt, Wolfgang Daniel, additional, Kunze, Catarina Alisa, additional, Darb-Esfahani, Sylvia, additional, Kulbe, Hagen, additional, Braicu, Elena Ioana, additional, Sehouli, Jalid, additional, Denkert, Carsten, additional, Horst, David, additional, and Taube, Eliane Tabea, additional

Published
2022
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5. Prognostic value of regulatory T cells and T helper 17 cells in high grade serous ovarian carcinoma

Author

Marchenko, Sofya, primary, Piwonski, Iris, additional, Hoffmann, Inga, additional, Sinn, Bruno Valentin, additional, Kunze, Catarina Alisa, additional, Monjé, Nanna, additional, Pohl, Jonathan, additional, Kulbe, Hagen, additional, Schmitt, Wolfgang Daniel, additional, Darb-Esfahani, Sylvia, additional, Braicu, Elena Ioana, additional, von Brünneck, Ann-Christin, additional, Sehouli, Jalid, additional, Denkert, Carsten, additional, Horst, David, additional, Jöhrens, Korinna, additional, and Taube, Eliane Tabea, additional

Published
2022
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6. Correction: MGMT promoter methylation in triple negative breast cancer of the GeparSixto trial

Author

Jank, Paul, primary, Gehlhaar, Claire, additional, Lederer, Bianca, additional, Fontanella, Caterina, additional, Schneeweiss, Andreas, additional, Karn, Thomas, additional, Marmé, Frederik, additional, Sinn, Hans-Peter, additional, van Mackelenbergh, Marion, additional, Sinn, Bruno, additional, Zahm, Dirk-Michael, additional, Ingold-Heppner, Barbara, additional, Schem, Christian, additional, Stickeler, Elmar, additional, Fasching, Peter A., additional, Nekljudova, Valentina, additional, Taube, Eliane Tabea, additional, Heppner, Frank, additional, Müller, Volkmar, additional, Denkert, Carsten, additional, and Loibl, Sibylle, additional

Published
2021
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7. Prognostic significance of Ki-67 levels and hormone receptor expression in low-grade serous ovarian carcinoma: an investigation of the Tumor Bank Ovarian Cancer Network

Author

Sehouli, Jalid, Braicu, Elena Ioana, Richter, Rolf, Denkert, Carsten, Jank, Paul, Jurmeister, Philipp Sebastian, Kunze, Catarina Alisa, Budczies, Jan, Darb-Esfahani, Sylvia, Schmitt, Wolfgang Daniel, Traut, Alexander, Grabowski, Jacek, Taube, Eliane Tabea, Plett, Helmut, and Taube, ElianeTabea

Subjects
Adult, 0301 basic medicine, Oncology, medicine.medical_specialty, Medizin, Estrogen receptor, Pathology and Forensic Medicine, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Ovarian carcinoma, Internal medicine, Progesterone receptor, Biomarkers, Tumor, medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, Ovarian Neoplasms, biology, business.industry, Middle Aged, Prognosis, medicine.disease, Immunohistochemistry, Progression-Free Survival, Cystadenocarcinoma, Serous, Survival Rate, Serous fluid, Ki-67 Antigen, 030104 developmental biology, Receptors, Estrogen, Hormone receptor, 030220 oncology & carcinogenesis, Ki-67, biology.protein, Female, Cancer biomarkers, Receptors, Progesterone, business, Ovarian cancer
Abstract

Summary Low-grade serous ovarian carcinoma (LGSOC) has recently come up as a distinct rare entity of epithelial ovarian cancer. Predictive and prognostic markers are not well studied yet. Because Ki-67 and hormone receptors (HR) have been established as relevant cancer biomarkers in several malignant tumors, we evaluated Ki-67 and HR expression rates by immunohistochemistry in 68 patients with LGSOC. We used a standardized cutoff finder algorithm to analyze prognostic significance for overall survival (OS) and progression-free survival (PFS). Cox regression showed a significant continuous decrease in OS for higher proliferation rates with an HR of 1.07% (95% confidence interval, 1.01%-3.67%; P = .048) but not in PFS (P = .86). Cutoff finder analysis revealed the best possible cutoff for OS at 6.28% (P = .04) and for PFS at 1.85% proliferative activity (P = .04). Estrogen receptors (ERs) were expressed in most LGSOC patients (n = 61; 89.7%), progesterone receptor (PR) in about half of patients (n = 33; 48.5%). For both ER/PR, a statistically significant cutoff for PFS could be determined, which was at 75% of positive tumor cells for ER (P = .02) and at 15% of positive tumor cells for PR (P = .03). For OS, HR expression showed a tendency toward better OS for HR-positive tumors but did not turn out statistically significant. Our results show that Ki-67 is a valuable prognostic marker in the subgroup of LGSOC. We could also show that most LGSOCs express HRs but that this expression is associated with a better PFS, a finding valuable in times of antihormonal therapy in LGSOC.

Published
2019

9. MGMT promoter methylation in triple negative breast cancer of the GeparSixto trial

Author

Jank, Paul, primary, Gehlhaar, Claire, additional, Bianca, Lederer, additional, Caterina, Fontanella, additional, Andreas, Schneeweiss, additional, Karn, Thomas, additional, Marmé, Frederik, additional, Sinn, Hans-Peter, additional, van Mackelenbergh, Marion, additional, Sinn, Bruno, additional, Zahm, Dirk-Michael, additional, Ingold-Heppner, Barbara, additional, Schem, Christian, additional, Stickeler, Elmar, additional, Fasching, Peter A., additional, Nekljudova, Valentina, additional, Taube, Eliane Tabea, additional, Heppner, Frank, additional, Müller, Volkmar, additional, Denkert, Carsten, additional, and Loibl, Sibylle, additional

Published
2020
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11. Rapid progression of aortic and mitral stenosis in a patient with AA amyloidosis: a case report

Author

Frumkin, David, Taube, Eliane Tabea, Stangl, Karl, and Knebel, Fabian

Subjects
Chronic kidney disease, Case report, Left ventricular hypertrophy, Case Reports, Cardiac amyloidosis, Aortic valve stenosis, Mitral valve stenosis, Dialysis, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

Background Aortic stenosis is a common finding in cardiac amyloidosis (CA). Younger patients often remain asymptomatic. If unrecognized, this can lead to serious complications such as heart failure. Progression of aortic stenosis can be accelerated in patients with chronic kidney disease and need for dialysis. Perioperative risk in these patients is often high due to the underlying systemic disease. Case summary A 40-year-old Caucasian man with known AA amyloidosis, highly active Ankylosing Spondylitis and need for chronic dialysis due to end-stage chronic renal failure presented for echocardiographic routine exam without reporting any cardiac symptoms. At the last visit 4 years ago, a normal heart valve function was noted and no echocardiographic follow-up was performed in the following. Now, rapid progression with severe aortic valve and mitral valve stenosis was stated and the patient underwent combined aortic and mitral surgical valve replacement following discussion in the multidisciplinary cardiology meeting. Macroscopic examination of the valves revealed significant calcification and histological examination showed the high presence of amyloid by Congo-red staining and immunohistological staining for AA-Amyloid. Both valve prosthetic devices showed normal function as well as a normal left ventricular ejection fraction in initial post-operative transoesophageal echocardiography. After prolonged and complicated post-operative course in the intensive care unit the patient died 3 months after surgery due to intractable multiorgan failure in combined severe abdominal septic and cardiogenic shock. Discussion Concomitant CA and chronic dialysis can accelerate the onset of severe aortic valve stenosis. Young patients, as in this case, often stay asymptomatic, perioperative risk increases with duration of chronic dialysis and severity of valve stenosis. This increases the need for regular short-term echocardiographic examinations even in clinical stable patients.

Published
2019

15. Ligneous Cervicitis in a Woman With Plasminogen Deficiency Associated With an Atypical Form of Microglandular Hyperplasia

Author

Taube, Eliane Tabea, primary, Frangini, Sergio, additional, Caselitz, Jörg, additional, Chiantera, Vito, additional, Pahl, Stephan, additional, Vercellino, Guiseppe Filiberto, additional, Ullrich, Andrea, additional, von Cotta, Guido, additional, Dietel, Manfred, additional, Younes, Shadi, additional, and Denkert, Carsten, additional

Published
2013
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