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1. Rehabilitation of Post-COVID Patients: A Virtual Reality Home-Based Intervention Including Cardio-Respiratory Fitness Training

Author

Colombo, V., Mondellini, Marta, Tauro, G., Palumbo, G., Rossini, M., Biffi, E., Nossa, R., Fumagalli, A., Ambrosini, E., Pedrocchi, A., Molteni, F., Colombo, D., Reni, G., Sacco, M., Arlati, S., Mondellini M. (ORCID:0000-0002-9578-4586), Colombo, V., Mondellini, Marta, Tauro, G., Palumbo, G., Rossini, M., Biffi, E., Nossa, R., Fumagalli, A., Ambrosini, E., Pedrocchi, A., Molteni, F., Colombo, D., Reni, G., Sacco, M., Arlati, S., and Mondellini M. (ORCID:0000-0002-9578-4586)

Abstract

The post-COVID syndrome is emerging as a new chronic condition, characterized by symptoms of breathlessness, fatigue, and decline of neurocognitive functions. Rehabilitation programs that include physical training seem to be beneficial to reduce such symptoms and improve patients’ quality of life. Given this, and considering the limitations imposed by the pandemic on rehabilitation services, it emerged the need to integrate telerehabilitation programs into clinical practice. Some telerehabilitation solutions, also based on virtual reality (VR), are available in the market. Still, they mainly focus on rehabilitation of upper limbs, balance, and cognitive training, while exercises like cycling or walking are usually not considered. The presented work aims to fill this gap by integrating a VR application to provide cardio-respiratory fitness training to post-COVID patients in an existing telerehabilitation platform. The ARTEDIA application allows patients to perform a cycling exercise and a concurrent cognitive task. Patients can cycle in a virtual park while performing a “go/no-go” task by selecting only specific targets appearing along the way. The difficulty of the practice can be adjusted by the therapists, while the physiological response is continuously monitored through wearable sensors to ensure safety. The application has been integrated into the VRRS system by Khymeia. In the next months, a study to assess the feasibility of a complete telerehabilitation program based on physical and cognitive training will take place. Such a program will combine the existing VRRS exercises and the cardio-respiratory fitness exercise provided by the ARTEDIA application. Feasibility, acceptance, and usability will be assessed from both the patients’ and the therapists’ sides.

Published
2022

2. Design of a Car Simulator to Assess Driving Capabilities in People with Disability

Author

Tauro, G., Redaelli, D. F., Dao, L. A., Mastropietro, A., Mondellini, Marta, Storm, F., Colombo, V., Arlati, S., Pirovano, I., Chiappini, M., Dei, C., Greci, L., Malosio, M., Rizzo, G., Reni, G., Sacco, M., Mondellini, M. (ORCID:0000-0002-9578-4586), Tauro, G., Redaelli, D. F., Dao, L. A., Mastropietro, A., Mondellini, Marta, Storm, F., Colombo, V., Arlati, S., Pirovano, I., Chiappini, M., Dei, C., Greci, L., Malosio, M., Rizzo, G., Reni, G., Sacco, M., and Mondellini, M. (ORCID:0000-0002-9578-4586)

Abstract

Disabilities related to motor and/or cognitive impairment may impact driving abilities. The project Rip@rto aims at supporting INAIL personnel during the evaluation of the residual capabilities of people with disability who apply for a driving license. The newly designed simulator presents new features compared to the current state of art. It will provide a realistic 3D environment and a mechatronic platform to improve the realism of the driving experience. The simulator will also allow collecting objective (mental workload) and subjective (stress, risk perception, user-experience) data to support the operator's decision.

Published
2022

11. Results of intensive therapy in childhood acute myeloid leukemia, incorporating high-dose melphalan and autologous bone marrow transplantation in first complete remission

Author

Keith Waters, Dianne Tucker, Karin Tiedemann, Henry Ekert, and Tauro G

Subjects
Melphalan, Male, medicine.medical_specialty, Time Factors, Cyclophosphamide, Adolescent, medicine.medical_treatment, Immunology, Transplantation, Autologous, Biochemistry, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Child, Survival rate, Bone Marrow Transplantation, Probability, Chemotherapy, business.industry, Childhood Acute Myeloid Leukemia, Remission Induction, Complete remission, Infant, Cell Biology, Hematology, Combined Modality Therapy, Survival Analysis, Confidence interval, Surgery, medicine.anatomical_structure, surgical procedures, operative, Leukemia, Myeloid, Child, Preschool, Acute Disease, Female, Bone marrow, business, medicine.drug
Abstract

Childhood acute myeloid leukemia (AML) has a poor prognosis with standard chemotherapy. Allogeneic bone marrow transplantation (BMT) in remission improves the outlook only for the one third of patients with sibling donors. Autologous BMT with a lower morbidity and mortality is available to all. In this study, maximum cytoreduction was achieved by intensive early chemotherapy. Final intensification, with autologous BMT was offered to all those remaining in first complete remission (CR). Patients received two induction and two consolidation courses of intensively scheduled chemotherapy. Cytoreduction was assessed on day 14 and remission was assessed after courses 2 and 4. Bone marrow was harvested after recovery from the second consolidation course or after the first maintenance course and separated on a discontinuous percoll gradient before cryopreservation. Twenty-eight of 31 consecutively enrolled patients achieved CR. Three relapsed early and, of the 25 eligible, 24 underwent autologous BMT. Twenty-three patients received high-dose melphalan and 1 received busulphan and cyclophosphamide before autologous BMT at a median of 113 days (range, 86 to 301) after initial CR. Trilineage engraftment occurred in all. Neutrophil recovery to greater than 0.5 x 10(9)/L occurred at a median of 46 days (range, 13 to 92) after autologous BMT. Platelet recovery was delayed, with a median time to achieve greater than 20 x 10(9)/L of 42 days (range, 18 to 215). With a minimum follow up of 25 months following autologous BMT only 3 children have relapsed. The 5-year event-free survival rate (EFS) from diagnosis is 68% (95% confidence interval, 46% to 90%). Five- year EFS following autologous BMT is 87% (95% confidence interval, 67% to 100%). Autologous BMT with high-dose melphalan administration after intensive chemotherapy has produced EFS equivalent to allogeneic BMT and is associated with a strikingly low relapse rate. High-dose melphalan appears to be a valuable agent for conditioning therapy in AML.

Published
1993
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14. Effect of the Philadelphia chromosome on minimal residual disease in acute lymphoblastic leukemia

Author

SH Neoh, Elizabeth Hughes, Gaynor Dolman, L Peng, Tauro G, Henry Ekert, I. Toogood, Pamela J. Sykes, Kenneth F. Bradstock, Michael J. Brisco, and Alec Morley

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Fusion Proteins, bcr-abl, Chromosomal translocation, Chromosome Disorders, Drug resistance, Philadelphia chromosome, Polymerase Chain Reaction, Translocation, Genetic, law.invention, law, hemic and lymphatic diseases, Acute lymphocytic leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, medicine, Humans, Child, Polymerase chain reaction, Aged, Chromosome Aberrations, Chemotherapy, business.industry, Cytogenetics, Infant, hemic and immune systems, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Prognosis, Minimal residual disease, humanities, Oncology, Child, Preschool, Immunology, Female, business
Abstract

The Philadelphia translocation is associated with a poor prognosis in adults and children with acute lymphoblastic leukemia, even though the majority of patients achieve remission. To test the hypothesis that the translocation leads to drug resistance in vivo, we studied 61 children and 20 adults with acute lymphoblastic leukemia and used the level of minimal residual disease at the end of induction as the measure of drug resistance in vivo. In children the presence of the translocation was associated with a significant increase in residual disease, indicating higher drug resistance in vivo; five of seven Philadelphia-positive children but only five of 54 Philadelphia-negative children had a minimal residual disease level10(-3), a level which is associated with a high risk of relapse in childhood acute lymphoblastic leukemia of standard risk. By contrast, in adults, residual disease and hence drug resistance was already higher than in children, and the presence of the Philadelphia translocation in seven patients had no obvious additional effect. We conclude that the Philadelphia chromosome may increase resistance to drugs in vivo in children, but not detectably in adults.

Published
1997

25. Autologous bone marrow rescue in the treatment of advanced tumors of childhood

Author

W. Mary Ellis, Tauro G, Henry Ekert, and Keith Waters

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Pathology, business.industry, Retinoblastoma, Liter, Granulocyte, medicine.disease, Cryopreservation, Lymphoma, medicine.anatomical_structure, Neuroblastoma, Internal medicine, Medicine, Stage (cooking), business, Rhabdomyosarcoma
Abstract

High-dose multiagent chemotherapy followed by autologous marrow rescue was used in the treatment of 13 patients with Stage III or IV childhood tumors. Encouraging results are being obtained in abdominal lymphoma (1/3 complete remissions (CR); rhabdomyosarcoma (2/4 CR); and retinoblastoma (1/2 CR). In neuroblastoma, the results are disappointing, with only one of four patients in CR; this patient developed a lymphoma associated with Epstein-Barr virus infection. Marrow reconstitution was obtained in 11 patients, with recovery of neutrophils to greater than 0.5 x 10(9)/liter between six and 30 days and platelet recovery to greater than 50 x 10(9)/liter between seven and 38 days. Investigations on the numbers of cells or committed granulocyte precursors ()CFU-c's) infused and parameters of hematologic recovery show poor correlation and suggest that a more accurate and reliable assay for the predictability of cryopreserved marrow to reconstitute marrow function within a reasonable time is necessary. Nonhematologic toxicities of high-dose multiagent chemotherapy are the principal dose-limiting factors.

Published
1982
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26. Hemophagocytic reticulosisA case report with investigations of immune and white cell function

Author

P. Fullerton, Henry Ekert, C. Hosking, and Tauro G

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, Vinblastine, Immune system, Oncology, Immunology, medicine, Prednisolone, business, medicine.drug
Abstract

A 5-month-old child with hemophagocytic reticulosis is described. Investigations revealed a grossly defective PHA response of the patient's lymphocytes which improved with chemotherapy. Defective glucose oxidation by phagocytosing cells and low IgA levels were demonstrated at diagnosis and have persisted despite chemotherapy. HL-A typing and chromosome studies did not reveal maternal lymphocytes in the child's circulation. The patient was treated with vinblastine and prednisolone and remains well after 11 months of treatment.

Published
1975
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27. Left shift in the peripheral blood count at diagnosis in acute lymphocytic leukemia is significantly correlated with duration of complete remission

Author

BJ Shen, Henry Ekert, A Balderas, and Tauro G

Subjects
medicine.medical_specialty, Proportional hazards model, business.industry, Immunology, Complete remission, Cell Biology, Hematology, medicine.disease, Gastroenterology, Biochemistry, Peripheral blood, Surgery, Leukemia, Internal medicine, Acute lymphocytic leukemia, Left shift, medicine, Likely outcome, Single institution, business
Abstract

The prognostic significance of a left shift in the peripheral blood at the time of diagnosis of acute lymphocytic leukemia was investigated by a retrospective analysis of 109 patients treated on the same protocol in a single institution. Left shift was defined as the presence of 1% or more of metamyelocytes, myelocytes, or promyelocytes. All peripheral blood films were checked at the time of diagnosis by one of the authors. It was found that the duration of complete remission at 92 mo was 74% in patients with left shift and 42% in those without left shift (p less than 0.05, log-rank test). By Cox regression analysis, only the total white cell count (p less than 0.001) and the presence or absence of left shift (p less than 0.01) were independently significant in determining the proportion of patients in complete remission. Patients with a left shift had a significantly higher granulocyte count at diagnosis (p less than 0.05). We postulate that left shift in the peripheral blood count at the time of diagnosis may be an indirect measure of the total leukemia cell load. It is a new prognostic factor of significance in determining the likely outcome of the disease.

Published
1984
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29. The quantitation of haemoglobin A2and haemoglobin F: A report of the techniques review group of the thalassaemia society of Victoria

Author

Cauchi, M.N. and Tauro, G.

Abstract

A techniques review group was established in 1975 to investigate the reproducibility of tests for HbA2and HbF for the diagnosis of β thalassaemia. Over a 3-year period, 22 samples were distributed for analysis by up to 14 laboratories. Of 250 estimations of HbA2, 26 (10.4%) were at variance with the majority result. The largest number of variant results were obtained in samples with a HbA2close to the upper limit of normal. Of 238 HbF determinations, 29 (12%) were equivocal or at variance with the majority result. It is concluded that the techniques of HbA2and HbF estimation as currently practised by several laboratories are not sufficiently accurate, and that, therefore, a number of cases of β thalassaemia are not being diagnosed. It is the opinion of those participating in the study that the survey is of value in providing a continuing review of techniques and a forum for discussion.

Published
1979
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30. MIXED LEUKAEMIA: A REPORT OF THREE CASES

Author

O'Neill, B. J., McCredie, K. B., Raik, E., and Tauro, G. P.

Abstract

A series of three cases of mixed leukaemia encountered In Sydney during a four‐year period is reported. In each of these cases, blood and bonemarrow changes were present which could be interpreted only as being due to the simultaneous presence of chronic lymphocytic leukaemia and acute myeloblastic leukaemia. Radiotherapy or antimitotic chemotherapy does not seem to have been a causative agent in any of these cases.

Published
1920
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33. Outcome prediction in childhood acute lymphoblastic leukaemia by molecular quantification of residual disease at the end of induction

Author

Elizabeth Hughes, Tauro G, Michael J. Brisco, I. Toogood, Henry Ekert, Alexander A. Morley, Ram Seshadri, Keith Waters, J. Condon, SH Neoh, and Pamela J. Sykes

Subjects
Oncology, Male, medicine.medical_specialty, medicine.medical_treatment, Molecular Sequence Data, Clone (cell biology), Disease, Gene Rearrangement, T-Lymphocyte, Polymerase Chain Reaction, Sensitivity and Specificity, law.invention, Leukocyte Count, law, Recurrence, Risk Factors, hemic and lymphatic diseases, Internal medicine, Acute lymphocytic leukemia, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Life Tables, Child, Polymerase chain reaction, Proportional Hazards Models, Randomized Controlled Trials as Topic, Chemotherapy, biology, Base Sequence, business.industry, Remission Induction, Bone Marrow Examination, General Medicine, DNA, Neoplasm, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Prognosis, Minimal residual disease, Clinical trial, Survival Rate, Treatment Outcome, Evaluation Studies as Topic, Immunology, biology.protein, Female, Antibody, Drug Screening Assays, Antitumor, business
Abstract

Methods to detect and quantify minimal residual disease (MRD) after chemotherapy for acute lymphoblastic leukaemia (ALL) could improve treatment by identifying patients who need more or less intensive therapy. We have used a clone-specific polymerase chain reaction to detect rearranged immunoglobulin heavy-chain gene from the leukaemic clone, and quantified the clone by limiting dilution analysis. MRD was successfully quantified, by extracting DNA from marrow slides, from 88 of 181 children with ALL, who had total leucocyte counts below 100 x 10 9 /L at presentation and were enrolled in two clinical trials, in 1980-84 and 1985-89. Leukaemia was detected in the first remission marrow of 38 patients, in amounts between 6·7 x 10 -2 and 9·9 x 10 -7 cells; 26 of these patients relapsed. Of 50 patients with no MRD detected, despite study of 522-496 000 genomes, only 6 relapsed. The association between MRD detection and outcome was significant for patients in each trial. In the first trial, patients relapsed at all levels of detected MRD, whereas in the later trial, in which treatment was more intensive and results were better, the extent of MRD was closely related to the probability of relapse (5 of 5 patients with > 10 -3 MRD, 4 of 10 with 10 -3 to 2 x 10 -5 , 0 of 3 with levels below 2 x 10 -5 , and 2 of 26 with no MRD detected). Early quantification of leukaemic cells after chemotherapy may be a successful strategy for predicting outcome and hence individualising treatment in childhood ALL, because the results indicate both in-vivo drug sensitivity of the leukaemia and the number of leukaemic cells that remain to be killed by post-induction therapy.

41. Unveiling the strong interaction among hadrons at the LHC

Author

Acharya, Shreyasi, Adamova, Dagmar, Ahn, Sang Un, Bhattacharjee, Buddhadeb, Yurchenko, Volodymyr, Zaccolo, Valentina, Zaman, Ali, Zampolli, Chiara, Correia Zanoli, Henrique Jose, Zardoshti, Nima, Zarochentsev, Andrey, Zavada, Petr, Zavyalov, Nikolay, Zbroszczyk, Hanna Paulina, Bianchi, Antonio, Zhalov, Mikhail, Zhang, Song, Zhang, Xiaoming, Zhang, Zuman, Zherebchevskii, Vladimir, Yu, Zhi, Zhou, Daicui, Zhou, You, Zhou, Zhuo, Zhu, Jianhui, Bianchi, Livio, Zhu, Ya, Zichichi, Antonino, Zinovjev, Gennady, Zurlo, Nicola, ALICE Collaboration, Bianchi, Nicola, Bielcik, Jaroslav, Bielcikova, Jana, Bilandzic, Ante, Biro, Gabor, Biswas, Rathijit, Biswas, Saikat, Akbar, Zaenal, Blair, Justin Thomas, Blau, Dmitry, Blume, Christoph, Boca, Gianluigi, Bock, Friederike, Bogdanov, Alexey, Boi, Stefano, Bok, Jeongsu, Boldizsar, Laszlo, Bolozdynya, Alexander, Akindinov, Alexander, Bombara, Marek, Bonomi, Germano, Borel, Herve, Borissov, Alexander, Bossi, Hannah, Botta, Elena, Bratrud, Lars, Braun-munzinger, Peter, Bregant, Marco, Broz, Michal, Al-turany, Mohammad, Bruna, Elena, Bruno, Giuseppe Eugenio, Buckland, Matthew Daniel, Budnikov, Dmitry, Buesching, Henner, Bufalino, Stefania, Bugnon, Ophelie, Buhler, Paul Alois, Buncic, Predrag, Buthelezi, Edith Zinhle, Alam, Sk Noor, Bashir Butt, Jamila, Bysiak, Sebastian Adam, Caffarri, Davide, Caliva, Alberto, Calvo Villar, Ernesto, Mejia Camacho, Juan Manuel, Soto Camacho, Rabi, Camerini, Paolo, De Moraes Canedo, Fabio, Capon, Aaron Allan, Silva De Albuquerque, Danilo, Carnesecchi, Francesca, Caron, Robin Albert Andre, Castillo Castellanos, Javier Ernesto, Castro, Andrew John, Casula, Ester Anna Rita, Catalano, Fabio, Ceballos Sanchez, Cesar, Chakraborty, Pritam, Chandra, Sinjini, Chang, Wan, Aleksandrov, Dmitry, Chapeland, Sylvain, Chartier, Marielle, Chattopadhyay, Subhasis, Chattopadhyay, Sukalyan, Chauvin, Alex Henri Jean, Cheshkov, Cvetan Valeriev, Cheynis, Brigitte, Chibante Barroso, Vasco Miguel, Dobrigkeit Chinellato, David, Cho, Soyeon, Alessandro, Bruno, Chochula, Peter, Chowdhury, Tasnuva, Christakoglou, Panagiotis, Christensen, Christian Holm, Christiansen, Peter, Chujo, Tatsuya, Cicalo, Corrado, Cifarelli, Luisa, De Cilladi, Lorenzo, Cindolo, Federico, Alfanda, Haidar Mas'ud, Ciupek, Michael Rudolf, Clai, Giulia, Cleymans, Jean Willy Andre, Colamaria, Fabio Filippo, Colella, Domenico, Collu, Alberto, Colocci, Manuel, Concas, Matteo, Conesa Balbastre, Gustavo, Conesa Del Valle, Zaida, Alfaro Molina, Jose Ruben, Contin, Giacomo, Contreras Nuno, Jesus Guillermo, Cormier, Thomas Michael, Corrales Morales, Yasser, Cortese, Pietro, Cosentino, Mauro Rogerio, Costa, Filippo, Costanza, Susanna, Crochet, Philippe, Cuautle Flores, Eleazar, Adler, Alexander, Ali, Bushra, Cui, Pengyao, Cunqueiro Mendez, Leticia, Dabrowski, Daniel, Dahms, Torsten, Dainese, Andrea, Damas, Florian Paul Andre, Danisch, Meike Charlotte, Danu, Andrea, Das, Debasish, Das, Indranil, Ali, Yasir, Das, Prottay, Das, Prottoy, Das, Supriya, Dash, Ajay Kumar, Dash, Sadhana, De, Sudipan, De Caro, Annalisa, De Cataldo, Giacinto, De Cuveland, Jan, De Falco, Alessandro, Alici, Andrea, De Gruttola, Daniele, De Marco, Nora, De Pasquale, Salvatore, Deb, Suman, Franz Degenhardt, Hermann, Deja, Kamil Rafal, Deloff, Andrzej, Delsanto, Silvia, Deng, Wenjing, Dhankher, Preeti, Alizadehvandchali, Negin, Di Bari, Domenico, Di Mauro, Antonio, Arteche Diaz, Raul, Dietel, Thomas, Raisig, Pascal, Ding, Yanchun, Divia, Roberto, Dixit, Dhruv Utpalkumar, Djuvsland, Oeystein, Dmitrieva, Uliana, Alkin, Anton, Dobrin, Alexandru Florin, Donigus, Benjamin, Dordic, Olja, Dubey, Anand Kumar, Dubla, Andrea, Dudi, Sandeep, Mallick, Dukhishyam, Dupieux, Pascal, Ehlers Iii, Raymond James, Eikeland, Viljar Nilsen, Alme, Johan, Elia, Domenico, Erazmus, Barbara Ewa, Erhardt, Filip, Erokhin, Andrey, Ersdal, Magnus Rentsch, Espagnon, Bruno, Eulisse, Giulio, Evans, David, Evdokimov, Sergey, Fabbietti, Laura, Alt, Torsten, Faggin, Mattia, Faivre, Julien, Fan, Feng, Fantoni, Alessandra, Fasel, Markus, Fecchio, Pietro, Feliciello, Alessandro, Feofilov, Grigorii, Fernandez Tellez, Arturo, Ferrero, Andrea, Altenkamper, Lucas, Ferretti, Alessandro, Festanti, Andrea, Feuillard, Victor Jose Gaston, Figiel, Jan, Filchagin, Sergey, Finogeev, Dmitry, Fionda, Fiorella, Fiorenza, Gabriele, Flor, Fernando Antonio, Flores, Amanda Nicole, Altsybeev, Igor, Foertsch, Siegfried Valentin, Foka, Panagiota, Fokin, Sergey, Fragiacomo, Enrico, Frankenfeld, Ulrich Michael, Fuchs, Ulrich, Furget, Christophe, Furs, Artur, Fusco Girard, Mario, Gaardhoeje, Jens Joergen, Anaam, Mustafa, Gagliardi, Martino, Gago Medina, Alberto Martin, Gal, Arthur Willem Jean, Duarte Galvan, Carlos, Ganoti, Paraskevi, Garabatos Cuadrado, Jose, Alvarado Garcia, Jesus Ricardo, Garcia-solis, Edmundo Javier, Garg, Kunal, Gargiulo, Corrado, Adolfsson, Jonatan, Andrei, Cristian, Garibli, Aydan, Garner, Katharina, Gasik, Piotr Jan, Gauger, Erin Frances, De Leone Gay, Maria Beatriz, Germain, Marie, Ghosh, Jhuma, Ghosh, Premomoy, Ghosh, Sanjay Kumar, Giacalone, Marco, Andreou, Dimitra, Gianotti, Paola, Giubellino, Paolo, Giubilato, Piero, Glaenzer, Aude Marie Camille, Glassel, Peter, Gomez Ramirez, Andres, Gonzalez, Victor, Gonzalez Trueba, Laura Helena, Gorbunov, Sergey, Gorlich, Lidia Maria, Andronic, Anton, Goswami, Ankita, Gotovac, Sven, Grabski, Varlen, Graczykowski, Lukasz Kamil, Graham, Katie Leanne, Greiner, Leo Clifford, Grelli, Alessandro, Grigoras, Costin, Grigoryev, Vladislav, Grigoryan, Ara, Angeletti, Massimo, Grigoryan, Smbat, Groettvik, Ola Slettevoll, Grosa, Fabrizio, Grosse-oetringhaus, Jan Fiete, Grosso, Raffaele, Guernane, Rachid, Guittiere, Manuel, Gulbrandsen, Kristjan Herlache, Gunji, Taku, Gupta, Anik, Anguelov, Venelin, Gupta, Ramni, Bautista Guzman, Irais, Haake, Rudiger, Habib, Michael Karim, Hadjidakis, Cynthia Marie, Hamagaki, Hideki, Hamar, Gergoe, Hamid, Mohammed, Hannigan, Ryan Patrick, Haque, Md Rihan, Anson, Christopher Daniel, Harlenderova, Alena, Harris, John William, Harton, Austin Vincent, Hasenbichler, Jan Anton, Hassan, Hadi, Hassan, Qamar Ul, Hatzifotiadou, Despina, Hauer, Philip, Havener, Laura Brittany, Hayashi, Shinichi, Anticic, Tome, Heckel, Stefan Thomas, Hellbar, Ernst, Helstrup, Haavard, Herghelegiu, Andrei Ionut, Herman, Tomas, Gonzalez Hernandez, Emma, Herrera Corral, Gerardo Antonio, Herrmann, Florian, Hetland, Kristin Fanebust, Hillemanns, Hartmut, Antinori, Federico, Hills, Christopher, Hippolyte, Boris, Hohlweger, Bernhard, Honermann, Jan, Horak, David, Hornung, Andrea, Hornung, Sebastian, Hosokawa, Ritsuya, Hristov, Peter Zahariev, Huang, Chun-lu, Antonioli, Pietro, Hughes, Charles, Huhn, Patrick, Humanic, Thomas, Hushnud, Hushnud, Husova, Lucia Anna, Hussain, Nur, Hussain, Syed Asad, Hutter, Dirk, Iddon, James Philip, Ilkaev, Radiy, Apadula, Nicole, Ilyas, Hira, Inaba, Motoi, Innocenti, Gian Michele, Ippolitov, Mikhail, Isakov, Artem, Islam, Md Samsul, Ivanov, Marian, Ivanov, Vladimir, Izucheev, Vladimir, Jacak, Barbara, Aggarwal, Madan Mohan, Aphecetche, Laurent Bernard, Jacazio, Nicolo, Jacobs, Peter Martin, Jadlovska, Slavka, Jadlovsky, Jan, Jaelani, Syaefudin, Jahnke, Cristiane, Jakubowska, Monika Joanna, Janik, Malgorzata Anna, Janson, Thomas, Jercic, Marko, Appelshaeuser, Harald, Jevons, Oliver Thomas, Jin, Muqing, Jonas, Florian, Jones, Peter Graham, Jung, Jerome, Jung, Michael, Jusko, Anton, Kalinak, Peter, Kalweit, Alexander Philipp, Kaplin, Vladimir, Arcelli, Silvia, Kar, Somnath, Karasu Uysal, Ayben, Karatovic, David, Karavichev, Oleg, Karavicheva, Tatiana, Karczmarczyk, Przemyslaw, Karpechev, Evgeny, Kazantsev, Andrey, Kebschull, Udo Wolfgang, Keidel, Ralf, Arnaldi, Roberta, Keil, Markus, Ketzer, Bernhard Franz, Khabanova, Zhanna, Khan, Ahsan Mehmood, Khan, Shaista, Khanzadeev, Alexei, Kharlov, Yury, Khatun, Anisa, Khuntia, Arvind, Kileng, Bjarte, Arratia Munoz, Miguel Ignacio, Kim, Beomkyu, Kim, Byungchul, Kim, Daehyeok, Kim, Dong Jo, Kim, Eun Joo, Kim, Hyeonjoong, Kim, Jaehyun, Kim, Jinsook, Kim, Jiyoung, Kim, Jungeol, Arsene, Ionut Cristian, Kim, Junlee, Kim, Minjung, Kim, Se Yong, Kim, Taejun, Kim, Taesoo, Kirsch, Stefan, Kisel, Ivan, Kiselev, Sergey, Kisiel, Adam Ryszard, Klay, Jennifer Lynn, Arslandok, Mesut, Klein, Carsten, Klein, Jochen, Klein, Spencer Robert, Klein-boesing, Christian, Kleiner, Matthias, Kluge, Alexander, Knichel, Michael Linus, Knospe, Anders Garritt, Kobdaj, Chinorat, Kohler, Markus Konrad, Augustinus, Andre, Kollegger, Thorsten Sven, Kondratyev, Andrey, Kondratyeva, Natalia, Kondratyuk, Evgeny, Konig, Joshua Leon, Konigstorfer, Stephan Alexander, Konopka, Piotr Jan, Kornakov, Georgui, Koska, Lukas, Kovalenko, Oleksandr, Averbeck, Ralf Peter, Kovalenko, Vladimir, Kowalski, Marek, Kralik, Ivan, Kravcakova, Adela, Kreis, Lukas, Krivda, Marian, Krizek, Filip, Krizkova Gajdosova, Katarina, Kruger, Mario, Kryshen, Evgeny, Aziz, Sizar, Krzewicki, Mikolaj, Kubera, Andrew Michael, Kucera, Vit, Kuhn, Christian Claude, Kuijer, Paulus Gerardus, Kumar, Lokesh, Kundu, Sourav, Kurashvili, Podist, Kurepin, Alexander, Kurepin, Alexey, Aglieri Rinella, Gianluca, Azmi, Mohd Danish, Kuryakin, Alexey, Kushpil, Svetlana, Kvapil, Jakub, Kweon, Min Jung, Kwon, Jiyeon, Kwon, Youngil, La Pointe, Sarah Louise, La Rocca, Paola, Lai, Yue Shi, Lamanna, Massimo, Badala, Angela, Langoy, Rune, Lapidus, Kirill, Lardeux, Antoine Xavier, Larionov, Pavel, Laudi, Elisa, Lavicka, Roman, Lazareva, Tatiana, Lea, Ramona, Leardini, Lucia, Lee, Joonil, Baek, Yongwook, Lee, Seongjoo, Lehner, Sebastian, Lehrbach, Johannes, Lemmon, Roy Crawford, Leon Monzon, Ildefonso, Lesser, Ezra Douglas, Lettrich, Michael, Levai, Peter, Li, Xiaomei, Li, Xing Long, Bagnasco, Stefano, Lien, Jorgen Andre, Lietava, Roman, Lim, Bong-hwi, Lindenstruth, Volker, Lindner, Amelia, Lippmann, Christian, Lisa, Michael Annan, Liu, Alwina Ruixin, Liu, Jian, Liu, Suyuan, Bai, Xiaozhi, Llope, William Joseph, Lofnes, Ingrid Mckibben, Loginov, 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Mario, Skaali, Bernhard, Slupecki, Maciej, Smirnov, Nikolai, Snellings, Raimond, Soncco Meza, Carlos, Song, Jihye, Songmoolnak, Arnon, Soramel, Francesca, Bencedi, Gyula, Sorensen, Soren Pontoppidan, Sputowska, Iwona Anna, Stachel, Johanna, Stan, Ionel, Steffanic, Patrick John, Stenlund, Evert Anders, Stiefelmaier, Stephan Friedrich, Stocco, Diego, Storetvedt, Maksim Melnik, Dello Stritto, Luigi, Beole, Stefania, Alarcon Do Passo Suaide, Alexandre, Sugitate, Toru, Suire, Christophe Pierre, Suleymanov, Mais Kazim Oglu, Suljic, Miljenko, Sultanov, Rishat, Sumbera, Michal, Sumberia, Vikash, Sumowidagdo, Suharyo, Swain, Sagarika, Bercuci, Alexandru, Szabo, Alexander, Szarka, Imrich, Tabassam, Uzma, Taghavi, Seyed Farid, Taillepied, Guillaume, Takahashi, Jun, Tambave, Ganesh Jagannath, Tang, Siyu, Tarhini, Mohamad, Tarzila, Madalina-gabriela, Ahmad, Shakeel, Berdnikov, Yaroslav, Tauro, Arturo, Tejeda Munoz, Guillermo, Telesca, Adriana, Terlizzi, Livia, Terrevoli, Cristina, Thakur, 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A., Martinengo, P., Martinez, J. L., Martinez, M. I., Garcia, G. M., Masciocchi, S., Masera, M., Masoni, A., Massacrier, L., Masson, E., Mastroserio, A., Mathis, A. M., Matonoha, O., Matuoka, P. F. T., Matyja, A., Mayer, C., Mazzaschi, F., Mazzilli, M., Mazzoni, M. A., Mechler, A. F., Meddi, F., Melikyan, Y., Menchaca-Rocha, A., Mengke, C., Meninno, E., Menon, A. S., Meres, M., Mhlanga, S., Miake, Y., Micheletti, L., Migliorin, L. C., Mihaylov, D. L., Mikhaylov, K., Mishra, A. N., Miskowiec, D., Modak, A., Mohammadi, N., Mohanty, A. P., Mohanty, B., Khan, M. M., Moravcova, Z., Mordasini, C., Moreira De Godoy, D. A., Moreno, L. A. P., Morozov, I., Morsch, A., Mrnjavac, T., Muccifora, V., Mudnic, E., Muhlheim, D., Muhuri, S., Mulligan, J. D., Mulliri, A., Munhoz, M. G., Munzer, R. H., Murakami, H., Murray, S., Musa, L., Musinsky, J., Myers, C. J., Myrcha, J. W., Naik, B., Nair, R., Nandi, B. K., Nania, R., Nappi, E., Naru, M. U., Nassirpour, A. F., Nattrass, C., Nayak, R., Nayak, T. 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N., Uras, A., Usai, G. L., Vala, M., Valle, N., Vallero, S., van der Kolk, N., van Doremalen, L. V. R., van Leeuwen, M., Vyvre, P. V., Varga, D., Varga, Z., Varga-Kofarago, M., Vargas, A., Vasileiou, M., Vasiliev, A., Doce, O. V., Vechernin, V., Vercellin, E., Limon, S. V., Vermunt, L., Vernet, R., Vertesi, R., Vickovic, L., Vilakazi, Z., Baillie, O. V., Vino, G., Vinogradov, A., Virgili, T., Vislavicius, V., Vodopyanov, A., Volkel, B., Volkl, M. A., Voloshin, K., Voloshin, S. A., Volpe, G., von Haller, B., Vorobyev, I., Voscek, D., Vrlakova, J., Wagner, B., Weber, M., Weber, S. G., Wegrzynek, A., Wenzel, S. C., Wessels, J. P., Wiechula, J., Wikne, J., Wilk, G., Wilkinson, J., Willems, G. A., Willsher, E., Windelband, B., Winn, M., Witt, W. E., Wright, J. R., Wu, Y., Xu, R., Yalcin, S., Yamaguchi, Y., Yamakawa, K., Yang, S., Yano, S., Yin, Z., Yokoyama, H., Yoo, I. -K., Yoon, J. H., Yuan, S., Yuncu, A., Yurchenko, V., Zaccolo, V., Zaman, A., Zampolli, C., Zanoli, H. J. C., Zardoshti, N., Zarochentsev, A., Zavada, P., Zaviyalov, N., Zbroszczyk, H., Zhalov, M., Zhang, S., Zhang, X., Zhang, Z., Zherebchevskii, V., Zhi, Y., Zhou, D., Zhou, Y., Zhou, Z., Zhu, J., Zhu, Y., Zichichi, A., Zinovjev, G., Zurlo, N., Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique de Clermont (LPC), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ALICE, Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), S. 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Husova, N. Hussain, S. A. Hussain, D. Hutter, J. P. Iddon, R. Ilkaev, H. Ilyas, M. Inaba, G. M. Innocenti, M. Ippolitov, A. Isakov, M. S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, B. Jacak, N. Jacazio, P. M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M. J. Jakubowska, M. A. Janik, T. Janson, M. Jercic, O. Jevons, M. Jin, F. Jonas, P. G. Jones, J. Jung, M. Jung, A. Jusko, P. Kalinak, A. Kalweit, V. Kaplin, S. Kar, A. Karasu Uysal, D. Karatovic, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, A. Kazantsev, U. Kebschull, R. Keidel, M. Keil, B. Ketzer, Z. Khabanova, A. M. Khan, S. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, B. Kileng, B. Kim, B. Kim, D. Kim, D. J. Kim, E. J. Kim, H. Kim, J. Kim, J. S. Kim, J. Kim, J. Kim, J. Kim, M. Kim, S. Kim, T. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J. L. Klay, C. Klein, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, A. Kluge, M. L. Knichel, A. G. Knospe, C. Kobdaj, M. K. Köhler, T. Kollegger, A. Kondratyev, N. Kondratyeva, E. Kondratyuk, J. Konig, S. A. Konigstorfer, P. J. Konopka, G. Kornakov, L. Koska, O. Kovalenko, V. Kovalenko, M. Kowalski, I. Králik, A. Kravčáková, L. Kreis, M. Krivda, F. Krizek, K. Krizkova Gajdosova, M. Krüger, E. Kryshen, M. Krzewicki, A. M. Kubera, V. Kučera, C. Kuhn, P. G. Kuijer, L. Kumar, S. Kundu, P. Kurashvili, A. Kurepin, A. B. Kurepin, A. Kuryakin, S. Kushpil, J. Kvapil, M. J. Kweon, J. Y. Kwon, Y. Kwon, S. L. La Pointe, P. La Rocca, Y. S. Lai, M. Lamanna, R. Langoy, K. Lapidus, A. Lardeux, P. Larionov, E. Laudi, R. Lavicka, T. Lazareva, R. Lea, L. Leardini, J. Lee, S. Lee, S. Lehner, J. Lehrbach, R. C. Lemmon, I. León Monzón, E. D. Lesser, M. Lettrich, P. Lévai, X. Li, X. L. Li, J. Lien, R. Lietava, B. Lim, V. Lindenstruth, A. Lindner, C. Lippmann, M. A. Lisa, A. Liu, J. Liu, S. Liu, W. J. Llope, I. M. Lofnes, V. Loginov, C. Loizides, P. Loncar, J. A. Lopez, X. Lopez, E. López Torres, J. R. Luhder, M. Lunardon, G. Luparello, Y. G. Ma, A. Maevskaya, M. Mager, S. M. Mahmood, T. Mahmoud, A. Maire, R. D. Majka, M. Malaev, Q. W. Malik, L. Malinina, D. Mal’Kevich, P. Malzacher, G. Mandaglio, V. Manko, F. Manso, V. Manzari, Y. Mao, M. Marchisone, J. Mareš, G. V. Margagliotti, A. Margotti, A. Marín, C. Markert, M. Marquard, C. D. Martin, N. A. Martin, P. Martinengo, J. L. Martinez, M. I. Martínez, G. Martínez García, S. Masciocchi, M. Masera, A. Masoni, L. Massacrier, E. Masson, A. Mastroserio, A. M. Mathis, O. Matonoha, P. F. T. Matuoka, A. Matyja, C. Mayer, F. Mazzaschi, M. Mazzilli, M. A. Mazzoni, A. F. Mechler, F. Meddi, Y. Melikyan, A. Menchaca-Rocha, C. Mengke, E. Meninno, A. S. Menon, M. Meres, S. Mhlanga, Y. Miake, L. Micheletti, L. C. Migliorin, D. L. Mihaylov, K. Mikhaylov, A. N. Mishra, D. Miśkowiec, A. Modak, N. Mohammadi, A. P. Mohanty, B. Mohanty, M. Mohisin Khan, Z. Moravcova, C. Mordasini, D. A. Moreira De Godoy, L. A. P. Moreno, I. Morozov, A. Morsch, T. Mrnjavac, V. Muccifora, E. Mudnic, D. Mühlheim, S. Muhuri, J. D. Mulligan, A. Mulliri, M. G. Munhoz, R. H. Munzer, H. Murakami, S. Murray, L. Musa, J. Musinsky, C. J. Myers, J. W. Myrcha, B. Naik, R. Nair, B. K. Nandi, R. Nania, E. Nappi, M. U. Naru, A. F. Nassirpour, C. Nattrass, R. Nayak, T. K. Nayak, S. Nazarenko, A. Neagu, R. A. Negrao De Oliveira, L. Nellen, S. V. Nesbo, G. Neskovic, D. Nesterov, L. T. Neumann, B. S. Nielsen, S. Nikolaev, S. Nikulin, V. Nikulin, F. Noferini, P. Nomokonov, J. Norman, N. Novitzky, P. Nowakowski, A. Nyanin, J. Nystrand, M. Ogino, A. Ohlson, J. Oleniacz, A. C. Oliveira Da Silva, M. H. Oliver, C. Oppedisano, A. Ortiz Velasquez, A. Oskarsson, J. Otwinowski, K. Oyama, Y. Pachmayer, V. Pacik, S. Padhan, D. Pagano, G. Paić, J. Pan, S. Panebianco, P. Pareek, J. Park, J. E. Parkkila, S. Parmar, S. P. Pathak, B. Paul, J. Pazzini, H. Pei, T. Peitzmann, X. Peng, L. G. Pereira, H. Pereira Da Costa, D. Peresunko, G. M. Perez, S. Perrin, Y. Pestov, V. Petráček, M. Petrovici, R. P. Pezzi, S. Piano, M. Pikna, P. Pillot, O. Pinazza, L. Pinsky, C. Pinto, S. Pisano, D. Pistone, M. Płoskoń, M. Planinic, F. Pliquett, M. G. Poghosyan, B. Polichtchouk, N. Poljak, A. Pop, S. Porteboeuf-Houssais, V. Pozdniakov, S. K. Prasad, R. Preghenella, F. Prino, C. A. Pruneau, I. Pshenichnov, M. Puccio, J. Putschke, S. Qiu, L. Quaglia, R. E. Quishpe, S. Ragoni, S. Raha, S. Rajput, J. Rak, A. Rakotozafindrabe, L. Ramello, F. Rami, S. A. R. Ramirez, R. Raniwala, S. Raniwala, S. S. Räsänen, R. Rath, V. Ratza, I. Ravasenga, K. F. Read, A. R. Redelbach, K. Redlich, A. Rehman, P. Reichelt, F. Reidt, X. Ren, R. Renfordt, Z. Rescakova, K. Reygers, A. Riabov, V. Riabov, T. Richert, M. Richter, P. Riedler, W. Riegler, F. Riggi, C. Ristea, S. P. Rode, M. Rodríguez Cahuantzi, K. Røed, R. Rogalev, E. Rogochaya, D. Rohr, D. Röhrich, P. F. Rojas, P. S. Rokita, F. Ronchetti, A. Rosano, E. D. Rosas, K. Roslon, A. Rossi, A. Rotondi, A. Roy, P. Roy, O. V. Rueda, R. Rui, B. Rumyantsev, A. Rustamov, E. Ryabinkin, Y. Ryabov, A. Rybicki, H. Rytkonen, O. A. M. Saarimaki, R. Sadek, S. Sadhu, S. Sadovsky, K. Šafařík, S. K. Saha, B. Sahoo, P. Sahoo, R. Sahoo, S. Sahoo, P. K. Sahu, J. Saini, S. Sakai, S. Sambyal, V. Samsonov, D. Sarkar, N. Sarkar, P. Sarma, V. M. Sarti, M. H. P. Sas, E. Scapparone, J. Schambach, H. S. Scheid, C. Schiaua, R. Schicker, A. Schmah, C. Schmidt, H. R. Schmidt, M. O. Schmidt, M. Schmidt, N. V. Schmidt, A. R. Schmier, J. Schukraft, Y. Schutz, K. Schwarz, K. Schweda, G. Scioli, E. Scomparin, J. E. Seger, Y. Sekiguchi, D. Sekihata, I. Selyuzhenkov, S. Senyukov, D. Serebryakov, A. Sevcenco, A. Shabanov, A. Shabetai, R. Shahoyan, W. Shaikh, A. Shangaraev, A. Sharma, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sharma, O. Sheibani, K. Shigaki, M. Shimomura, S. Shirinkin, Q. Shou, Y. Sibiriak, S. Siddhanta, T. Siemiarczuk, D. Silvermyr, G. Simatovic, G. Simonetti, B. Singh, R. Singh, R. Singh, R. Singh, V. K. Singh, V. Singhal, T. Sinha, B. Sitar, M. Sitta, T. B. Skaali, M. Slupecki, N. Smirnov, R. J. M. Snellings, C. Soncco, J. Song, A. Songmoolnak, F. Soramel, S. Sorensen, I. Sputowska, J. Stachel, I. Stan, P. J. Steffanic, E. Stenlund, S. F. Stiefelmaier, D. Stocco, M. M. Storetvedt, L. D. Stritto, A. A. P. Suaide, T. Sugitate, C. Suire, M. Suleymanov, M. Suljic, R. Sultanov, M. Šumbera, V. Sumberia, S. Sumowidagdo, S. Swain, A. Szabo, I. Szarka, U. Tabassam, S. F. Taghavi, G. Taillepied, J. Takahashi, G. J. Tambave, S. Tang, M. Tarhini, M. G. Tarzila, A. Tauro, G. Tejeda Muñoz, A. Telesca, L. Terlizzi, C. Terrevoli, D. Thakur, S. Thakur, D. Thomas, F. Thoresen, R. Tieulent, A. Tikhonov, A. R. Timmins, A. Toia, N. Topilskaya, M. Toppi, F. Torales-Acosta, S. R. Torres, A. Trifiró, S. Tripathy, T. Tripathy, S. Trogolo, G. Trombetta, L. Tropp, V. Trubnikov, W. H. Trzaska, T. P. Trzcinski, B. A. Trzeciak, A. Tumkin, R. Turrisi, T. S. Tveter, K. Ullaland, E. N. Umaka, A. Uras, G. L. Usai, M. Vala, N. Valle, S. Vallero, N. van der Kolk, L. V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, A. Vargas, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vernet, R. Vértesi, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, J. Vrláková, B. Wagner, M. Weber, S. G. Weber, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, E. Willsher, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, Y. Wu, R. Xu, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, H. Yokoyama, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Yurchenko, V. Zaccolo, A. Zaman, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, H. Zbroszczyk, M. Zhalov, S. Zhang, X. Zhang, Z. Zhang, V. Zherebchevskii, Y. Zhi, D. Zhou, Y. Zhou, Z. Zhou, J. Zhu, Y. Zhu, A. Zichichi, G. Zinovjev & N. Zurlo, Helsinki Institute of Physics, Sub Subatomic Physics (SAP), Afd Subatomic Physics (SAP), Sub Algemeen Physics Education, and Subatomic Physics

Subjects
EXCHANGE-POTENTIAL APPROACH, Strange quark, ALICE Collaboration, Hadron, Nuclear Theory, Strong interaction, hadron collisions, Position and momentum space, hiukkasfysiikka, nucl-ex, 7. Clean energy, 01 natural sciences, VDP::Fysikk: 430, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Hadron-Hadron scattering (experiments), scattering [hadron], p p scattering, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], scattering [p p], Nuclear Experiment (nucl-ex), Experimental nuclear physics, NUCLEON, Nuclear Experiment, VDP::Physics: 430, Physics, Multidisciplinary, Large Hadron Collider, strong interaction, lattice [space-time], Publisher Correction, PRIRODNE ZNANOSTI. Fizika, BARYON-BARYON SCATTERING, CERN LHC Coll, LHC, ddc:500, Nucleon, Particle Physics - Experiment, discrete [space-time], Quark, Particle physics, CERN Lab, General Science & Technology, FOS: Physical sciences, short-range, Hadron, strong interaction, LHC, 114 Physical sciences, Fysikk: 430 [VDP], Article, hadron scattering, quark, ultrarelativistic proton–proton collisions, LHC, ALICE, 0103 physical sciences, Nuclear Physics - Experiment, General, 010306 general physics, Physics: 430 [VDP], interaction [hadron hadron], hep-ex, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, effect [strong interaction], hadron-hadron interaction, strong interaction: effect, space-time: discrete, space-time: lattice, correlation, NATURAL SCIENCES. Physics, Baryon, Hypernuclei, Neutron Stars, Strangeness, Physics::Accelerator Physics, High Energy Physics::Experiment, hadron, Experimental particle physics
Abstract

One of the key challenges for nuclear physics today is to understand from first principles the effective interaction between hadrons with different quark content. First successes have been achieved using techniques that solve the dynamics of quarks and gluons on discrete space-time lattices1,2. Experimentally, the dynamics of the strong interaction have been studied by scattering hadrons off each other. Such scattering experiments are difficult or impossible for unstable hadrons3–6 and so high-quality measurements exist only for hadrons containing up and down quarks7. Here we demonstrate that measuring correlations in the momentum space between hadron pairs8–12 produced in ultrarelativistic proton–proton collisions at the CERN Large Hadron Collider (LHC) provides a precise method with which to obtain the missing information on the interaction dynamics between any pair of unstable hadrons. Specifically, we discuss the case of the interaction of baryons containing strange quarks (hyperons). We demonstrate how, using precision measurements of proton–omega baryon correlations, the effect of the strong interaction for this hadron–hadron pair can be studied with precision similar to, and compared with, predictions from lattice calculations13,14. The large number of hyperons identified in proton–proton collisions at the LHC, together with accurate modelling15 of the small (approximately one femtometre) inter-particle distance and exact predictions for the correlation functions, enables a detailed determination of the short-range part of the nucleon-hyperon interaction., Correlations in momentum space between hadrons created by ultrarelativistic proton–proton collisions at the CERN Large Hadron Collider provide insights into the strong interaction, particularly the short-range dynamics of hyperons—baryons that contain strange quarks.

Published
2020
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42. Inclusivity is child's play: pilot study on usability, acceptability and user experience of a sensory-motor PC game for children with cerebral palsy (GiocAbile).

Author

Consales A, Biffi E, Nossa R, Pittaccio S, Lazzari F, Malosio M, Lavit Nicora M, Tauro G, Redaelli DF, Chaudhary A, Diella E, Valoriani M, Fedeli F, Picciolini O, Giannì ML, and Porro M

Subjects
Humans, Pilot Projects, Male, Child, Female, Patient Satisfaction, Surveys and Questionnaires, Cerebral Palsy rehabilitation, Video Games
Abstract

Background: The use of video games in rehabilitation settings is gaining increasing popularity. However, the lack of commercial video games suitable for children with disabilities and the disappointing user experience of serious games limit their applicability. The aim of this study was to assess the usability, acceptability and user experience of GiocAbile, an active video game for children with cerebral palsy (CP)., Methods: This multicenter pilot observational study was conducted from May to September 2022 at the participating institutions, and enrolled school-aged children affected by CP. Enrolled children played GiocAbile in single-player mode for one hour. The gaming experience was evaluated through self-assessment questionnaires. Non-parametric correlation analysis was conducted to examine the influence of motor and cognitive abilities (GMFCS, MACS, ICF) on declared usability and acceptability., Results: Nineteen children (9.01 ± 1.95 years, 63.1% male) with mild to severe CP were enrolled. The 100% of respondents expressed satisfaction and fulfillment associated with gameplay, with no reports of frustration or disappointment. The 83% would recommend the game to a friend. The controllers were generally deemed easy to use and maneuver, with very few reports of discomfort associated with their use. No correlations were found between usability/acceptability levels and measures of impairment (i.e., GMFCS, MACS, and ICF scales), while cognitive impairment positively correlated with satisfaction during gameplay., Conclusions: GiocAbile is an accessible, user-friendly and enjoyable tool for children with CP, regardless of level of impairment. Based on existing literature, we hypothesize that GiocAbile may improve motivation, participation, and rehabilitation outcomes in children with CP, although further studies are needed to confirm our hypothesis., Competing Interests: Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of Milano Area B (No 817; date of approval: 20/07/2021) and by the IRCCS Medea Ethics Committee (Prot. N. 89/21-CE; date of approval: 12/11/2021). Written informed consent was provided by parents/legal guardians of the children enrolled in the study. The study was conducted in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests., (© 2024. The Author(s).)

Published
2024
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43. Socially interactive agents for robotic neurorehabilitation training: conceptualization and proof-of-concept study.

Author

Arora R, Prajod P, Nicora ML, Panzeri D, Tauro G, Vertechy R, Malosio M, André E, and Gebhard P

Abstract

Introduction: Individuals with diverse motor abilities often benefit from intensive and specialized rehabilitation therapies aimed at enhancing their functional recovery. Nevertheless, the challenge lies in the restricted availability of neurorehabilitation professionals, hindering the effective delivery of the necessary level of care. Robotic devices hold great potential in reducing the dependence on medical personnel during therapy but, at the same time, they generally lack the crucial human interaction and motivation that traditional in-person sessions provide., Methods: To bridge this gap, we introduce an AI-based system aimed at delivering personalized, out-of-hospital assistance during neurorehabilitation training. This system includes a rehabilitation training device, affective signal classification models, training exercises, and a socially interactive agent as the user interface. With the assistance of a professional, the envisioned system is designed to be tailored to accommodate the unique rehabilitation requirements of an individual patient. Conceptually, after a preliminary setup and instruction phase, the patient is equipped to continue their rehabilitation regimen autonomously in the comfort of their home, facilitated by a socially interactive agent functioning as a virtual coaching assistant. Our approach involves the integration of an interactive socially-aware virtual agent into a neurorehabilitation robotic framework, with the primary objective of recreating the social aspects inherent to in-person rehabilitation sessions. We also conducted a feasibility study to test the framework with healthy patients., Results and Discussion: The results of our preliminary investigation indicate that participants demonstrated a propensity to adapt to the system. Notably, the presence of the interactive agent during the proposed exercises did not act as a source of distraction; instead, it positively impacted users' engagement., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Arora, Prajod, Nicora, Panzeri, Tauro, Vertechy, Malosio, André and Gebhard.)

Published
2024
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44. Gaze detection as a social cue to initiate natural human-robot collaboration in an assembly task.

Author

Lavit Nicora M, Prajod P, Mondellini M, Tauro G, Vertechy R, André E, and Malosio M

Abstract

Introduction: In this work we explore a potential approach to improve human-robot collaboration experience by adapting cobot behavior based on natural cues from the operator. Methods: Inspired by the literature on human-human interactions, we conducted a wizard-of-oz study to examine whether a gaze towards the cobot can serve as a trigger for initiating joint activities in collaborative sessions. In this study, 37 participants engaged in an assembly task while their gaze behavior was analyzed. We employed a gaze-based attention recognition model to identify when the participants look at the cobot. Results: Our results indicate that in most cases (83.74%), the joint activity is preceded by a gaze towards the cobot. Furthermore, during the entire assembly cycle, the participants tend to look at the cobot mostly around the time of the joint activity. Given the above results, a fully integrated system triggering joint action only when the gaze is directed towards the cobot was piloted with 10 volunteers, of which one characterized by high-functioning Autism Spectrum Disorder. Even though they had never interacted with the robot and did not know about the gaze-based triggering system, most of them successfully collaborated with the cobot and reported a smooth and natural interaction experience. Discussion: To the best of our knowledge, this is the first study to analyze the natural gaze behavior of participants working on a joint activity with a robot during a collaborative assembly task and to attempt the full integration of an automated gaze-based triggering system., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Lavit Nicora, Prajod, Mondellini, Tauro, Vertechy, André and Malosio.)

Published
2024
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45. Characterization of clonal immunoglobulin heavy chain and I cell receptor gamma gene rearrangements during progression of childhood acute lymphoblastic leukemia.

Author

Marshall GM, Kwan E, Haber M, Brisco MJ, Sykes PJ, Morley AA, Toogood I, Waters K, Tauro G, and Ekert H

Subjects
Adolescent, Base Sequence, Child, Child, Preschool, Clone Cells, DNA Primers chemistry, DNA, Neoplasm genetics, Female, Humans, Infant, Male, Molecular Sequence Data, Neoplasm, Residual diagnosis, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology, Time Factors, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor, Genes, Immunoglobulin, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics, Receptors, Antigen, T-Cell, gamma-delta genetics
Abstract

Instability of antigen receptor gene rearrangements during progression of acute lymphoblastic leukemia (ALL) has important implications for polymerase chain reaction (PCR)-based techniques using these genes for the detection of minimal residual disease (MRD). Antigen receptor gene instability may lead to false negative results in bone marrow samples taken during remission. Utilizing the PCR and consensus primers for rearranged immunoglobulin heavy chain (IgH) and T cell receptor gamma (TCR gamma) gene sequences, we analyzed the bone marrow samples at diagnosis and first relapse for 37 children with ALL. The incidence of clonal evolution at the IgH locus was 9/33 (27%) and at the TCR gamma locus 1/15 (7%). In four of the nine patients with clonal evolution at the IgH locus, the sequence at relapse retained the diversity and joining region (D-N-J) sequences from diagnosis. Patients with clonal evolution were characterized by a higher incidence of more than one IgH PCR band at diagnosis and by late relapse (> 18 months from diagnosis). These results suggest that, where possible, patients with more than one IgH PCR rearrangement at diagnosis should be monitored using another antigen receptor gene, such as TCR gamma, since evolution for this gene was found to be a rare event. By combining this approach with a strategy directed at the more stable D-N-J region of the IgH gene, MRD false negativity would have occurred in less than 10% of patients in the present study.

Published
1995

46. Results of intensive therapy in childhood acute myeloid leukemia, incorporating high-dose melphalan and autologous bone marrow transplantation in first complete remission.

Author

Tiedemann K, Waters KD, Tauro GP, Tucker D, and Ekert H

Subjects
Acute Disease, Adolescent, Child, Child, Preschool, Combined Modality Therapy adverse effects, Female, Humans, Infant, Leukemia, Myeloid mortality, Male, Probability, Remission Induction, Survival Analysis, Time Factors, Transplantation, Autologous, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bone Marrow Transplantation, Leukemia, Myeloid therapy, Melphalan therapeutic use
Abstract

Childhood acute myeloid leukemia (AML) has a poor prognosis with standard chemotherapy. Allogeneic bone marrow transplantation (BMT) in remission improves the outlook only for the one third of patients with sibling donors. Autologous BMT with a lower morbidity and mortality is available to all. In this study, maximum cytoreduction was achieved by intensive early chemotherapy. Final intensification, with autologous BMT was offered to all those remaining in first complete remission (CR). Patients received two induction and two consolidation courses of intensively scheduled chemotherapy. Cytoreduction was assessed on day 14 and remission was assessed after courses 2 and 4. Bone marrow was harvested after recovery from the second consolidation course or after the first maintenance course and separated on a discontinuous percoll gradient before cryopreservation. Twenty-eight of 31 consecutively enrolled patients achieved CR. Three relapsed early and, of the 25 eligible, 24 underwent autologous BMT. Twenty-three patients received high-dose melphalan and 1 received busulphan and cyclophosphamide before autologous BMT at a median of 113 days (range, 86 to 301) after initial CR. Trilineage engraftment occurred in all. Neutrophil recovery to greater than 0.5 x 10(9)/L occurred at a median of 46 days (range, 13 to 92) after autologous BMT. Platelet recovery was delayed, with a median time to achieve greater than 20 x 10(9)/L of 42 days (range, 18 to 215). With a minimum follow up of 25 months following autologous BMT only 3 children have relapsed. The 5-year event-free survival rate (EFS) from diagnosis is 68% (95% confidence interval, 46% to 90%). Five-year EFS following autologous BMT is 87% (95% confidence interval, 67% to 100%). Autologous BMT with high-dose melphalan administration after intensive chemotherapy has produced EFS equivalent to allogeneic BMT and is associated with a strikingly low relapse rate. High-dose melphalan appears to be a valuable agent for conditioning therapy in AML.

Published
1993

47. Prognostic significance of detection of monoclonality in remission marrow in acute lymphoblastic leukemia in childhood. Australian and New Zealand Children's Cancer Study Group.

Author

Brisco MJ, Condon J, Hughes E, Neoh SH, Nicholson I, Sykes PJ, Tauro G, Ekert H, Waters K, and Toogood I

Subjects
Bone Marrow chemistry, Bone Marrow Cells, Clone Cells physiology, DNA, Neoplasm analysis, DNA, Neoplasm genetics, Gene Amplification, Gene Rearrangement genetics, Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor genetics, Humans, Immunoglobulin Heavy Chains genetics, Lymphocytes physiology, Polymerase Chain Reaction, Precursor Cell Lymphoblastic Leukemia-Lymphoma blood, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology, Predictive Value of Tests, Prognosis, Receptors, Antigen, T-Cell, gamma-delta genetics, Remission Induction, Bone Marrow physiology, Genes, Immunoglobulin genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
Abstract

Techniques based on the polymerase chain reaction (PCR) to detect rearrangement of the immunoglobulin or T-cell receptor genes can detect residual disease in leukemia and hence have the potential to improve prognosis and treatment. Such techniques may involve either detection of monoclonality, which is simple and quick but has limited sensitivity, or specific detection of the leukaemic clone, which is complex and time-consuming but has high sensitivity. The PCR was used to detect monoclonal rearrangements of the immunoglobulin heavy chain and/or T-cell receptor gamma chain genes in archival marrow specimens from 185 children with acute lymphoblastic leukemia who achieved remission during two consecutive Australasian trials of treatment. A monoclonal rearrangement was detected at diagnosis in 152 (84%) patients and in these patients detection of the same rearrangement in the remission marrow at the end of induction therapy was highly significantly correlated with outcome. There were nine patients in whom polymerase chain reaction showed only the monoclonal rearrangement and eight (89%) relapsed; there were 26 patients in whom PCR showed the leukemic monoclonal rearrangement as well as polyclonal rearrangements from normal lymphocytes and 12 (46%) relapsed; and there were 117 patients in whom only polyclonal rearrangements could be detected and only 29 (25%) relapsed. In patients who relapsed, remissions were shorter in those patients in whom the leukemic rearrangements had been detected in the remission marrow. Treatment in the later trial was more intensive than in the earlier trial, the results were better and the PCR detected the leukemic rearrangement in the remission marrow in significantly fewer patients. We conclude that detection by PCR of the monoclonal gene rearrangement of the leukemic clone in remission marrow indicates that numerous leukemic cells have survived induction therapy and is a good predictor of relapse. However, due to limited sensitivity of the test, failure to detect the leukemic clone by PCR is not a sufficiently good predictor of ultimate cure.

Published
1993

49. Left shift in the peripheral blood count at diagnosis in acute lymphocytic leukemia is significantly correlated with duration of complete remission.

Author

Shen BJ, Ekert H, Tauro GP, and Balderas A

Subjects
Adolescent, Child, Child, Preschool, Female, Hematopoietic Stem Cells pathology, Humans, Infant, Leukemia, Lymphoid diagnosis, Leukemia, Lymphoid pathology, Long-Term Care, Male, Prognosis, Cell Transformation, Neoplastic pathology, Leukemia, Lymphoid blood, Leukocyte Count
Abstract

The prognostic significance of a left shift in the peripheral blood at the time of diagnosis of acute lymphocytic leukemia was investigated by a retrospective analysis of 109 patients treated on the same protocol in a single institution. Left shift was defined as the presence of 1% or more of metamyelocytes, myelocytes, or promyelocytes. All peripheral blood films were checked at the time of diagnosis by one of the authors. It was found that the duration of complete remission at 92 mo was 74% in patients with left shift and 42% in those without left shift (p less than 0.05, log-rank test). By Cox regression analysis, only the total white cell count (p less than 0.001) and the presence or absence of left shift (p less than 0.01) were independently significant in determining the proportion of patients in complete remission. Patients with a left shift had a significantly higher granulocyte count at diagnosis (p less than 0.05). We postulate that left shift in the peripheral blood count at the time of diagnosis may be an indirect measure of the total leukemia cell load. It is a new prognostic factor of significance in determining the likely outcome of the disease.

Published
1984

50. Dihydrofolate reductase deficiency causing megaloblastic anemia in two families.

Author

Tauro GP, Danks DM, Rowe PB, Van der Weyden MB, Schwarz MA, Collins VL, and Neal BW

Subjects
Anemia, Megaloblastic congenital, Anemia, Megaloblastic enzymology, Bone Marrow metabolism, Bone Marrow Cells, Child, Preschool, DNA biosynthesis, Deoxyuridine, Female, Humans, Infant, Newborn, Liver enzymology, Male, Tetrahydrofolate Dehydrogenase analysis, Anemia, Macrocytic genetics, Anemia, Megaloblastic genetics, Tetrahydrofolate Dehydrogenase deficiency
Abstract

To determine the cause of severe megaloblastosis detected at birth and at four weeks in two unrelated infants their bone marrow and liver cells were studied. Both patients had abnormal deoxyuridine suppression tests, corrected to normal by 5-formyl tetrahydrofolic acid. Liver-cell homogenate from one patient had a previously undetectable level of dihydrofolate reductase restored to normal by high cation concentration in the assay. Activity of the liver-cell homogenate from the other patient, which was one quarter of the normal level, was restored to only half normal activity by high cation concentration. Dihydrofolic acid reductase deficiency prevents this conversion of folic acid to tetrahydrofolic acid; the enzyme activity appears to differ in each patient. A satisfactory clinical response in both patients followed parenteral therapy with 5-formyl tetrahydrofolic acid. One sibling in each family died of a similar illness. Autosomal recessive inheritance is probable.

Published
1976
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