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4. A multicentre observational study on management of general anaesthesia in elderly patients at high-risk of postoperative adverse outcomes

Author

Bruder, N., Vaisse, C., Bechis, C., Bernard, L., Leone, M., Poirier, M., Vincent, A., Abdelkrim, N., Paugam, C., Lion, F., Montravers, P., Langeron, O., Raux, M., Baussier, M., Xu, K., Bart, F., Dagois, S., Plaud, B., Rabuel, C., Roland, E., Biais, M., Nouette-Gaulain, K., Cabart, A., Hanouz, J.L., Lambert, C., Godet, T., Thibault, S., Bouhemad, B., Chambade, E., Bouzat, P., Garot, M., Lebuffe, G., Lallemant, F., Lemery, C., Tavernier, B., de Jong, A., Jaber, S., Verzilli, D., Delannoy, M., Meistelman, C., Carles, M., Tran, L., Bertran, S., Cuvillon, P., Ripart, J., Simon-Pene, S., Boisson, M., Debaene, B., Beloeil, H., Godet, G., Collange, O., Mertes, P.M., Diemunsch, P., Joganah, D., Oehlkern, L., Baulieu, M., Beauchesne, B., Beraud, A.M., Berthier-Berrada, S., Bien, J.Y., Dupont, G., Gavory, J., Lambert, P., Lanoiselée, J., Zufferey, P., Ferré, F., Martin, C., Minville, V., Planté, B., Baffeleuf, B., Ben Abdelkarim, M., David, J.S., Incagnoli, P., Khaled, M., Laplace, M.C., Lefevre, M., Piriou, V., Aubrun, F., Cero, V., Delsuc, C., Faulcon, C., Meuret, P., Rimmelé, T., Truc, C., Molliex, Serge, Passot, Sylvie, Morel, Jerome, Futier, Emmanuel, Lefrant, Jean Yves, Constantin, Jean Michel, Le Manach, Yannick, and Pereira, Bruno

Published
2019
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7. Evaluation of a novel closed-loop fluid-administration system based on dynamic predictors of fluid responsiveness: An in silico simulation study

Author

Rinehart, J, Alexander, B, Manach, YL, Hofer, C, Tavernier, B, Kain, ZN, and Cannesson, M

Abstract

Introduction: Dynamic predictors of fluid responsiveness have made automated management of fluid resuscitation more practical. We present initial simulation data for a novel closed-loop fluid-management algorithm (LIR, Learning Intravenous Resuscitator).Methods: The performance of the closed-loop algorithm was tested in three phases by using a patient simulator including a pulse-pressure variation output. In the first phase, LIR was tested in three different hemorrhage scenarios and compared with no management. In the second phase, we compared LIR with 20 practicing anesthesiologists for the management of a simulated hemorrhage scenario. In the third phase, LIR was tested under conditions of noise and artifact in the dynamic predictor.Results: In the first phase, we observed a significant difference between the unmanaged and the LIR groups in moderate to large hemorrhages in heart rate (76 ± 8 versus 141 ± 29 beats/min), mean arterial pressure (91 ± 6 versus 59 ± 26 mm Hg), and cardiac output (CO; (6.4 ± 0.9 versus 3.2 ± 1.8 L/min) (P < 0.005 for all comparisons). In the second phase, LIR intervened significantly earlier than the practitioners (16.0 ± 1.3 minutes versus 21.5 ± 5.6 minutes; P < 0.05) and gave more total fluid (2,675 ± 244 ml versus 1,968 ± 644 ml; P < 0.05). The mean CO was higher in the LIR group than in the practitioner group (5.9 ± 0.2 versus 5.2 ± 0.6 L/min; P < 0.05). Finally, in the third phase, despite the addition of noise to the pulse-pressure variation value, no significant difference was found across conditions in mean, final, or minimum CO.Conclusion: These data demonstrate that LIR is an effective volumetric resuscitator in simulated hemorrhage scenarios and improved physician management of the simulated hemorrhages. © 2011 Cannesson et al.; licensee BioMed Central Ltd.

Published
2011

9. A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19: the DAWn-Antico study

Author

Vanassche, T., Engelen, M. M., Van Thillo, Q., Wauters, J., Gunst, J., Wouters, C., Vandenbriele, C., Rex, S., Liesenborghs, L., Wilmer, A., Meersseman, P., Van den Berghe, G., Dauwe, D., Verbeke, G., Thomeer, M., Fivez, T., Mesotten, D., Ruttens, D., Heytens, L., Dapper, I., Tuyls, S., De Tavernier, B., and Verhamme, P.

Published
2020
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31. Individualized Fluid Management Using the Pleth Variability Index: A Randomized Clinical Trial

Author

Fischer, M. O., Lemoine, S., Tavernier, B., Bouchakour, C. E., Colas, V., Houard, M., Greub, W., Daccache, G., Hulet, C., Compère, V., Taing, D., Lorne, Emmanuel, Parienti, J. J., Hanouz, J. L., Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département Anesthésie-Réanimation, Hôpital Roger Salengro, CHRU de Lille, Hôpital Roger Salengro, CHRU de Lille, Lille, France, GRAMAT (DAM/GRAMAT), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Systèmes Thermiques (GRETh/LETH), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre hospitalier de Saint-Quentin, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), and GRETh

Subjects
[SDV]Life Sciences [q-bio]
Abstract

BACKGROUND: The present trial was designed to assess whether individualized strategies of fluid administration using a noninvasive plethysmographic variability index could reduce the postoperative hospital length of stay and morbidity after intermediate-risk surgery. METHODS: This was a multicenter, randomized, nonblinded parallel-group clinical trial conducted in five hospitals. Adult patients in sinus rhythm having elective orthopedic surgery (knee or hip arthroplasty) under general anesthesia were enrolled. Individualized hemodynamic management aimed to achieve a plethysmographic variability index under 13%, and the standard management strategy aimed to maintain a mean arterial pressure above 65 mmHg during general anesthesia. The primary outcome was the postoperative hospital length of stay decided by surgeons blinded to the group allocation of the patient. RESULTS: In total, 447 patients were randomized, and 438 were included in the analysis. The mean hospital length of stay ± SD was 6 ± 3 days for the plethysmographic variability index group and 6 ± 3 days for the control group (adjusted difference, 0.0 days; 95% CI, -0.6 to 0.5; P = 0.860); the theoretical postoperative hospital length of stay was 4 ± 2 days for the plethysmographic variability index group and 4 ± 1 days for the control group (P = 0.238). In the plethysmographic variability index and control groups, serious postoperative cardiac complications occurred in 3 of 217 (1%) and 2 of 224 (1%) patients (P = 0.681), acute postoperative renal failure occurred in 9 (4%) and 8 (4%) patients (P = 0.808), the troponin Ic concentration was more than 0.06 μg/l within 5 days postoperatively for 6 (3%) and 5 (2%) patients (P = 0.768), and the postoperative arterial lactate measurements were 1.44 ± 1.01 and 1.43 ± 0.95 mmol/l (P = 0.974), respectively. CONCLUSIONS: Among intermediate-risk patients having orthopedic surgery with general anesthesia, fluid administration guided by the plethysmographic variability index did not shorten the duration of hospitalization or reduce complications.

Published
2020
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38. A multicentre observational study on management of general anaesthesia in elderly patients at high-risk of postoperative adverse outcomes

Author

Molliex, Serge, primary, Passot, Sylvie, additional, Morel, Jerome, additional, Futier, Emmanuel, additional, Lefrant, Jean Yves, additional, Constantin, Jean Michel, additional, Le Manach, Yannick, additional, Pereira, Bruno, additional, Bruder, N., additional, Vaisse, C., additional, Bechis, C., additional, Bernard, L., additional, Leone, M., additional, Poirier, M., additional, Vincent, A., additional, Abdelkrim, N., additional, Paugam, C., additional, Lion, F., additional, Montravers, P., additional, Langeron, O., additional, Raux, M., additional, Baussier, M., additional, Xu, K., additional, Bart, F., additional, Dagois, S., additional, Plaud, B., additional, Rabuel, C., additional, Roland, E., additional, Biais, M., additional, Nouette-Gaulain, K., additional, Cabart, A., additional, Hanouz, J.L., additional, Lambert, C., additional, Godet, T., additional, Thibault, S., additional, Bouhemad, B., additional, Chambade, E., additional, Bouzat, P., additional, Garot, M., additional, Lebuffe, G., additional, Lallemant, F., additional, Lemery, C., additional, Tavernier, B., additional, de Jong, A., additional, Jaber, S., additional, Verzilli, D., additional, Delannoy, M., additional, Meistelman, C., additional, Carles, M., additional, Tran, L., additional, Bertran, S., additional, Cuvillon, P., additional, Ripart, J., additional, Simon-Pene, S., additional, Boisson, M., additional, Debaene, B., additional, Beloeil, H., additional, Godet, G., additional, Collange, O., additional, Mertes, P.M., additional, Diemunsch, P., additional, Joganah, D., additional, Oehlkern, L., additional, Baulieu, M., additional, Beauchesne, B., additional, Beraud, A.M., additional, Berthier-Berrada, S., additional, Bien, J.Y., additional, Dupont, G., additional, Gavory, J., additional, Lambert, P., additional, Lanoiselée, J., additional, Zufferey, P., additional, Ferré, F., additional, Martin, C., additional, Minville, V., additional, Planté, B., additional, Baffeleuf, B., additional, Ben Abdelkarim, M., additional, David, J.S., additional, Incagnoli, P., additional, Khaled, M., additional, Laplace, M.C., additional, Lefevre, M., additional, Piriou, V., additional, Aubrun, F., additional, Cero, V., additional, Delsuc, C., additional, Faulcon, C., additional, Meuret, P., additional, Rimmelé, T., additional, and Truc, C., additional

Published
2019
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40. P2662Prognostic value of postoperative high-sensitivity troponin among patients undergoing fenestrated and/or branched endovascular aortic aneurysm repair

Author

Moussa, M D, primary, Lamer, A, additional, Mass, G, additional, Louvel, P, additional, Lecaitel, S, additional, Hertault, A, additional, Gantois, G, additional, Leroy, G, additional, Ait-Ouarab, S, additional, Brandt, C, additional, Kipnis, E, additional, Sobocinski, J, additional, Tavernier, B, additional, Haulon, S, additional, and Robin, E, additional

Published
2018
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41. Axial displacement of abutments into implants and implant replicas, with the tapered cone-screw internal connection, as a function of tightening torque.

Author

Dailey B, Jordan L, Blind O, and Tavernier B

Abstract

Purpose: The passive fit of a superstructure on implant abutments is essential to success. One source of error when using a tapered cone-screw internal connection may be the difference between the tightening torque level applied to the abutments by the laboratory technician compared to that applied by the treating clinician. The purpose of this study was to measure the axial displacement of tapered cone-screw abutments into implants and their replicas as a function of the tightening torque level. Materials and Methods: Twenty tapered cone-screw abutments were selected. Two groups were created: 10 abutments were secured into 10 implants, and 10 abutments were secured into 10 corresponding implant replicas. Each abutment was tightened in increasing increments of 5 Ncm, from 0Ncm to 45 Ncm, with a torque controller. The length of each sample was measured repeatedly with an Electronic Digital Micrometer. The mean axial displacement for the implant group and the replica group was calculated. The data were analyzed by the Mann-Whitney and Spearman tests. Results: For both groups, there was always an axial displacement of the abutment upon each incremental application of torque. The mean axial displacement values varied between 7 and 12 micro-m for the implant group and between 6 and 21 micro-m for the replica group at each 5-Ncm increment. From 0 to 45 Ncm, the total mean axial displacement values were 89 micro-m for the implant group and 122 micro-m for the replica group. Conclusion: There was a continuous axial displacement of the abutments into implants and implant replicas when the applied torque was raised from 0 to 45 Ncm. Torque applied above the level recommended by the manufacturer increased the difference in displacement between the two groups. INT J ORAL MAXILLOFAC IMPLANTS 2009;24:251-256 [ABSTRACT FROM AUTHOR]

Published
2009

44. Genome-wide association study indentifies variants at CLU and CR1 associated with Alzheimer’s disease

Author

Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, European Alzheimer's Disease Initiative Investigators, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanché H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alpérovitch A, Lathrop M, Amouyel P, FORTI, PAOLA, Lambert, J, Heath, S, Even, G, Campion, D, Sleegers, K, Hiltunen, M, Cambarros, O, Zelenika, D, Bullido, M, Tavernier, B, Letenneur, L, Bettens, K, Berr, C, Pasquier, F, Fiévet, N, Barbager Gateau, P, Engelborghs, S, De Deyn, P, Mateo, I, Franck, A, Helisalmi, S, Porcellini, E, Hanon, O, the European Alzheimer’s disease Initiative, I, de Pancorbo, M, Lendon, C, Dufouil, C, Jaillard, C, Leveillard, T, Alvarez, V, Bosco, P, Mancuso, M, Panza, F, Nacmias, B, Bossù, P, Piccardi, P, Annoni, G, Seripa, D, Galimberti, D, Hannequin, D, Licastro, F, Soininen, H, Ritchie, K, Blanché, H, Dartigues, J, Tzourio, C, Gut, I, Broeckhoven, C, Alpérovitch, A, Lathrop, M, Amouyel, P, Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, European Alzheimer's Disease Initiative Investigator, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanché H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alpérovitch A, Lathrop M, Amouyel P, Electronics and Informatics, Clinical sciences, Neurology, and Pathologic Biochemistry and Physiology

Subjects
Apolipoprotein E, SORL1, Genome-wide association study, Disease, Polymorphism, Single Nucleotide, White People, ABCA7, PICALM, Alzheimer Disease, Genetics, Humans, Genetic Predisposition to Disease, European Continental Ancestry Group/genetics, Alzheimer's disease, genome-wide association, APOE, APOJ, Medicine(all), Alzheimer Disease/genetics, biology, Phosphatidylinositol binding, Clusterin, Haplotypes, Receptors, Complement 3b, biology.protein, Human medicine, Clusterin/genetics, Receptors, Complement 3b/genetics, Genome-Wide Association Study
Abstract

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wide association study of 2,032 individuals from France with Alzheimer's disease (cases) and 5,328 controls. Markers outside APOE with suggestive evidence of association (P 10 5) were examined in collections from Belgium, Finland, Italy and Spain totaling 3,978 Alzheimer's disease cases and 3,297 controls. Two loci gave replicated evidence of association: one within CLU (also called APOJ), encoding clusterin or apolipoprotein J, on chromosome 8 (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7.5 × 10 9 for combined data) and the other within CR1, encoding the complement component (3b/4b) receptor 1, on chromosome 1 (rs6656401, OR = 1.21, 95% CI 1.14-1.29, P = 3.7 × 10 9 for combined data). Previous biological studies support roles of CLU and CR1 in the clearance of Β amyloid (AΒ) peptide, the principal constituent of amyloid plaques, which are one of the major brain lesions of individuals with Alzheimer's disease. © 2009 Nature America, Inc. All rights reserved.

Published
2009

46. Effects of Halothane on Mechanical Response of Skeletal Muscle from Malignant Hyperthermia Susceptible Patients

Author

G. Haudecoeur, T. Etchrivi, Tavernier B, Diallo A, P. J. Adnet, and Krivosic-Horber Rm

Subjects
Contraction (grammar), Physiology, Vastus lateralis muscle, Biopsy, Isometric exercise, In Vitro Techniques, Membrane Potentials, Nuclear magnetic resonance, Normal muscle, Caffeine, Physiology (medical), medicine, Humans, Muscle, Skeletal, Chemistry, Malignant hyperthermia, Skeletal muscle, General Medicine, Anatomy, medicine.disease, Muscle bundle, medicine.anatomical_structure, Anesthetics, Inhalation, Disease Susceptibility, Halothane, Malignant Hyperthermia, Muscle Contraction, medicine.drug
Abstract

The purpose of this investigation was to compare the effects of halothane on malignant hyperthermia (MH) and normal isolated muscle bundle performance during isometric contraction and relaxation phases. Mechanical parameters were measured: peak tension (PT), time to peak tension (TPT) and positive peak of isometric tension derivative (+dP/dtmax) characterized the contraction phase. Half-relaxation time (RT1/2) and negative peak of isometric tension derivative (-dP/dtmax) characterized the relaxation phase. The ratio R = (+dP/dtmax)/(-dP/dtmax) was used to study the coupling between contraction and relaxation under isometric condition. In normal muscle, halothane increased PT by nearly 40% without altering TPT. The +dP/dtmax value increased concomitantly with the -dP/dtmax values, thus no changes in R was observed. In MH muscle, PT was first potentiated (0.5-1.0 vol% halothane) and then depressed (2.0-3.0 vol% halothane). TPT and +dP/dtmax were not altered whereas RT1/2 increased progressively with concomitant decrease in -dP/dtmax, thus R increased by nearly 40%. The amplitude of MH muscle contracture with stepwise concentrations of halothane was correlated with the increase of RT1/2 and R, and the decrease of -dP/dtmax. These results suggest that halothane alters the relaxation phase more than the contraction phase in MH human skeletal muscle compared to normal muscle.

Published
1998
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47. THE CALCIUM SENSITIZER EMD 57033 INCREASES CONTRACTILITY TO A GREATER EXTENT IN MYOCYTES ISOLATED FROM ENDOTOXAEMIC THAN CONTROL RATS

Author

Patterson, M, Layland, J, Tavernier, B, and Shah, A M.

Subjects
Heart muscle -- Physiological aspects -- Usage, Rats as laboratory animals -- Usage -- Physiological aspects, Septic shock -- Care and treatment, Muscle contraction -- Physiological aspects -- Usage, Health
Abstract

Gram negative endotoxaemia is associated with an intrinsic impairment of cardiac myocyte contractility, but the underlying sub-cellular mechanisms that are responsible remain uncertain. We investigated the function of cardiac myocytes [...]

Published
2001

48. Etude de la dégradation à hautes températures de matériaux d'outils d'emboutissage vis-à-vis d'une tôle USIBOR 1500P revêtue AluSi: Quantification expérimentale de l’adhésion

Author

Boher, Christine, Penazzi, Luc, Lucin, V., Tovar, S., Dessain, C., Tavernier, B., Le Roux, Sabine, Institut Clément Ader (ICA), Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi)-Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)

Subjects
[PHYS.MECA.MSMECA]Physics [physics]/Mechanics [physics]/Materials and structures in mechanics [physics.class-ph], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2011

49. Etude de la dégradation à hautes températures de matériaux d’outils d’emboutissage vis-à vis d’une tôle USIBOR 1500P revêtue AluSi : quantification expérimentale de l’adhésion

Author

Christine BOHER, Luc Penazzi, Sabine Le Roux, Lucin, V., Tovar, S., Dessain, C., Tavernier, B., Institut Clément Ader (ICA), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
[PHYS.MECA.MSMECA]Physics [physics]/Mechanics [physics]/Materials and structures in mechanics [physics.class-ph], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2011

50. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

Author

Lambert, Jc, Heath, S, Even, G, Campion, D, Sleegers, K, Hiltunen, M, Combarros, O, Zelenika, D, Bullido, Mj, Tavernier, B, Letenneur, L, Bettens, K, Berr, C, Pasquier, F, Fiévet, N, BARBERGER GATEAU, P, Engelborghs, S, DE DEYN, P, Mateo, I, Franck, A, Helisalmi, S, Porcellini, E, Hanon, O, Siciliano, Gabriele, DE PANCORBO MM, Lendon, C, Dufouil, C, Jaillard, C, Leveillard, T, Alvarez, V, Bosco, P, Mancuso, Michelangelo, Panza, F, Nacmias, B, Bossù, P, Piccardi, P, Annoni, G, Seripa, D, Galimberti, D, Hannequin, D, Licastro, F, Soininen, H, Ritchie, K, Blanché, H, Dartigues, Jf, Tzourio, C, Gut, I, VAN BROECKHOVEN, C, Alpérovitch, A, Lathrop, M, and Amouyel, P.

Published
2009

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