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233 results on '"Tavolari, Simona"'

9. Current and novel therapeutic opportunities for systemic therapy in biliary cancer

Author

Marin, José J. G., Prete, Maria Giuseppina, Lamarca, Angela, Tavolari, Simona, Landa-Magdalena, Ana, Brandi, Giovanni, Segatto, Oreste, Vogel, Arndt, Macias, Rocío I. R., Rodrigues, Pedro M., Casta, Adelaida La, Mertens, Joachim, Rodrigues, Cecilia M. P., Fernandez-Barrena, Maite G., Da Silva Ruivo, Ana, Marzioni, Marco, Mentrasti, Giulia, Acedo, Pilar, Munoz-Garrido, Patricia, Cardinale, Vincenzo, Banales, Jesus M., Valle, Juan W., Bridgewater, John, and Braconi, Chiara

Published
2020
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11. Prognostic value of microRNA-21 in intra- and extrahepatic cholangiocarcinoma after radical resection: cohort study.

Author

Boyd, Lenka N C, Ali, Mahsoem, Comandatore, Annalisa, Brandi, Giovanni, Tavolari, Simona, Gaeta, Raffaele, Meijer, Laura L, Large, Tessa Y S Le, Riefolo, Mattia, Vasuri, Francesco, Morelli, Luca, Laarhoven, Hanneke W M van, Giovannetti, Elisa, Kazemier, Geert, and Garajová, Ingrid

Subjects
PROGNOSIS, CHOLANGIOCARCINOMA, MICRORNA, CLINICAL prediction rules, COHORT analysis, INFORMED consent (Medical law)
Abstract

This article explores the potential use of microRNA-21 (miR-21) as a prognostic marker for cholangiocarcinoma, a type of cancer that affects the bile ducts. The study analyzed data from patients who underwent surgery for cholangiocarcinoma and found that miR-21 expression was associated with overall survival. The researchers suggest that incorporating miR-21 into prognostic models could enhance risk assessment and provide more accurate prognosis estimates for cholangiocarcinoma patients. The study concludes that miR-21 could be a valuable independent predictor of overall survival in cholangiocarcinoma and may improve clinical decision-making for post-surgery patients. [Extracted from the article]

Published
2024
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13. Immune-Based Combination Therapies for Advanced Hepatocellular Carcinoma

Author

Carloni, Riccardo, additional, Sabbioni, Simone, additional, Rizzo, Alessandro, additional, Ricci, Angela Dalia, additional, Palloni, Andrea, additional, Petrarota, Cataldo, additional, Cusmai, Antonio, additional, Tavolari, Simona, additional, Gadaleta-Caldarola, Gennaro, additional, and Brandi, Giovanni, additional

Published
2023
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16. Correction: Current and novel therapeutic opportunities for systemic therapy in biliary cancer

Author

Marin, José J. G., Prete, Maria Giuseppina, Lamarca, Angela, Tavolari, Simona, Landa-Magdalena, Ana, Brandi, Giovanni, Segatto, Oreste, Vogel, Arndt, Macias, Rocío I. R., Rodrigues, Pedro M., La Casta, Adelaida, Mertens, Joachim, Rodrigues, Cecilia M. P., Fernandez-Barrena, Maite G., Da Silva Ruivo, Ana, Marzioni, Marco, Mentrasti, Giulia, Acedo, Pilar, Munoz-Garrido, Patricia, Cardinale, Vincenzo, Banales, Jesus M., Valle, Juan W., Bridgewater, John, and Braconi, Chiara

Published
2021
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17. Targeting STT3A produces an anti-tumor effect in lung adenocarcinoma by blocking the MAPK and PI3K/AKT signaling pathway

Author

Cheng, Jiahan, Xia, Liang, Hao, Xiaohu, Gan, Fanyi, Bai, Yuquan, Zhang, Chuanfen, Mao, Yonghong, Zhu, Yunke, Pu, Qiang, Park, Dong Won, Tavolari, Simona, Mei, Jiandong, Chen, Yaohui, Deng, Senyi, and Liu, Lunxu

Subjects
Oncology, Original Article
Abstract

BACKGROUND: Glycosylation is crucial for the stability and biological functions of proteins. The aberrant glycosylation of critical proteins plays an important role in multiple cancers, including lung adenocarcinoma (LUAD). STT3 oligosaccharyltransferase complex catalytic subunit A (STT3A) is a major isoform of N-linked glycosyltransferase that catalyzes the glycosylation of various proteins. However, the functions of STT3A in LUAD are still unclear. METHODS: The expression profiles of STT3A were initially analyzed in public data sets and then validated by quantitative real-time polymerase chain reaction, Western blot and immunohistochemistry assays in clinical LUAD samples. The overall survival (OS) between patients with high and low STT3A expression was compared using a Kaplan-Meier curve with a log-rank analysis. STT3A was knocked-out using CRISPR/Cas9 and inhibited by NGI-1. Cell Counting Kit-8, colony formation assay, wound-healing, transwell assay, and flow cytometry were performed to assess the cellular functions of STT3A in vitro. A mice xenograft model was established to investigate the effects of STT3A on tumor growth in vivo. Further, the downstream signaling pathways of STT3A were screened by mass spectrometry with a bioinformatics analysis, and the activation of the target pathways were subsequently validated by Western blot. RESULTS: The expression of STT3A was frequently upregulated in LUAD tissues than normal lung tissues. The high expression of STT3A was significantly associated with poor OS in LUAD patients. The knockout or inhibition of STT3A suppressed proliferation, migration, and invasion, and arrested the cell cycle of LUAD cell lines in vitro. Similarly, the knockout or inhibition of STT3A suppressed tumor growth in vivo. In terms of molecular mechanism, STT3A may promote LUAD progression by activating the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase and protein kinase B (PI3K/AKT) pathways and regulating the epithelial-mesenchymal transition. CONCLUSIONS: STT3A promotes LUAD progression via the MAPK and PI3K/AKT signaling pathways and could serve as a novel prognostic biomarker and potential therapeutic target for LUAD patients.

Published
2022

20. Data from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells

Author

Fornari, Francesca, primary, Gramantieri, Laura, primary, Giovannini, Catia, primary, Veronese, Angelo, primary, Ferracin, Manuela, primary, Sabbioni, Silvia, primary, Calin, George Adrian, primary, Grazi, Gian Luca, primary, Croce, Carlo Maria, primary, Tavolari, Simona, primary, Chieco, Pasquale, primary, Negrini, Massimo, primary, and Bolondi, Luigi, primary

Published
2023
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21. Supplementary Figure 1 from Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

Author

Studebaker, Adam W., primary, Storci, Gianluca, primary, Werbeck, Jillian L., primary, Sansone, Pasquale, primary, Sasser, A. Kate, primary, Tavolari, Simona, primary, Huang, Tim, primary, Chan, Michael W.Y., primary, Marini, Frank C., primary, Rosol, Thomas J., primary, Bonafé, Massimiliano, primary, and Hall, Brett M., primary

Published
2023
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22. Supplementary Figure 4 from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells

Author

Fornari, Francesca, primary, Gramantieri, Laura, primary, Giovannini, Catia, primary, Veronese, Angelo, primary, Ferracin, Manuela, primary, Sabbioni, Silvia, primary, Calin, George Adrian, primary, Grazi, Gian Luca, primary, Croce, Carlo Maria, primary, Tavolari, Simona, primary, Chieco, Pasquale, primary, Negrini, Massimo, primary, and Bolondi, Luigi, primary

Published
2023
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23. Supplementary Table 2 from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells

Author

Fornari, Francesca, primary, Gramantieri, Laura, primary, Giovannini, Catia, primary, Veronese, Angelo, primary, Ferracin, Manuela, primary, Sabbioni, Silvia, primary, Calin, George Adrian, primary, Grazi, Gian Luca, primary, Croce, Carlo Maria, primary, Tavolari, Simona, primary, Chieco, Pasquale, primary, Negrini, Massimo, primary, and Bolondi, Luigi, primary

Published
2023
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24. Data from Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

Author

Studebaker, Adam W., primary, Storci, Gianluca, primary, Werbeck, Jillian L., primary, Sansone, Pasquale, primary, Sasser, A. Kate, primary, Tavolari, Simona, primary, Huang, Tim, primary, Chan, Michael W.Y., primary, Marini, Frank C., primary, Rosol, Thomas J., primary, Bonafé, Massimiliano, primary, and Hall, Brett M., primary

Published
2023
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25. Supplementary Figure 2 from Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

Author

Studebaker, Adam W., primary, Storci, Gianluca, primary, Werbeck, Jillian L., primary, Sansone, Pasquale, primary, Sasser, A. Kate, primary, Tavolari, Simona, primary, Huang, Tim, primary, Chan, Michael W.Y., primary, Marini, Frank C., primary, Rosol, Thomas J., primary, Bonafé, Massimiliano, primary, and Hall, Brett M., primary

Published
2023
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26. Supplementary Figure 1 from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells

Author

Fornari, Francesca, primary, Gramantieri, Laura, primary, Giovannini, Catia, primary, Veronese, Angelo, primary, Ferracin, Manuela, primary, Sabbioni, Silvia, primary, Calin, George Adrian, primary, Grazi, Gian Luca, primary, Croce, Carlo Maria, primary, Tavolari, Simona, primary, Chieco, Pasquale, primary, Negrini, Massimo, primary, and Bolondi, Luigi, primary

Published
2023
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27. Supplementary Table 1 from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells

Author

Fornari, Francesca, primary, Gramantieri, Laura, primary, Giovannini, Catia, primary, Veronese, Angelo, primary, Ferracin, Manuela, primary, Sabbioni, Silvia, primary, Calin, George Adrian, primary, Grazi, Gian Luca, primary, Croce, Carlo Maria, primary, Tavolari, Simona, primary, Chieco, Pasquale, primary, Negrini, Massimo, primary, and Bolondi, Luigi, primary

Published
2023
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28. Supplementary Figure 2 from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells

Author

Fornari, Francesca, primary, Gramantieri, Laura, primary, Giovannini, Catia, primary, Veronese, Angelo, primary, Ferracin, Manuela, primary, Sabbioni, Silvia, primary, Calin, George Adrian, primary, Grazi, Gian Luca, primary, Croce, Carlo Maria, primary, Tavolari, Simona, primary, Chieco, Pasquale, primary, Negrini, Massimo, primary, and Bolondi, Luigi, primary

Published
2023
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29. Supplementary Figure Legends 1-4 from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells

Author

Fornari, Francesca, primary, Gramantieri, Laura, primary, Giovannini, Catia, primary, Veronese, Angelo, primary, Ferracin, Manuela, primary, Sabbioni, Silvia, primary, Calin, George Adrian, primary, Grazi, Gian Luca, primary, Croce, Carlo Maria, primary, Tavolari, Simona, primary, Chieco, Pasquale, primary, Negrini, Massimo, primary, and Bolondi, Luigi, primary

Published
2023
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30. Supplementary Figure 4 from Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

Author

Studebaker, Adam W., primary, Storci, Gianluca, primary, Werbeck, Jillian L., primary, Sansone, Pasquale, primary, Sasser, A. Kate, primary, Tavolari, Simona, primary, Huang, Tim, primary, Chan, Michael W.Y., primary, Marini, Frank C., primary, Rosol, Thomas J., primary, Bonafé, Massimiliano, primary, and Hall, Brett M., primary

Published
2023
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31. Supplementary Figure 3 from Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

Author

Studebaker, Adam W., primary, Storci, Gianluca, primary, Werbeck, Jillian L., primary, Sansone, Pasquale, primary, Sasser, A. Kate, primary, Tavolari, Simona, primary, Huang, Tim, primary, Chan, Michael W.Y., primary, Marini, Frank C., primary, Rosol, Thomas J., primary, Bonafé, Massimiliano, primary, and Hall, Brett M., primary

Published
2023
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32. Supplementary Figure 3 from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells

Author

Fornari, Francesca, primary, Gramantieri, Laura, primary, Giovannini, Catia, primary, Veronese, Angelo, primary, Ferracin, Manuela, primary, Sabbioni, Silvia, primary, Calin, George Adrian, primary, Grazi, Gian Luca, primary, Croce, Carlo Maria, primary, Tavolari, Simona, primary, Chieco, Pasquale, primary, Negrini, Massimo, primary, and Bolondi, Luigi, primary

Published
2023
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34. Single-cell analysis for medical research: a narrative review

Author

Qian, Lin, primary, Mou, Haoya, additional, Yue, Yan, additional, Liu, Jing, additional, Huang, R. Stephanie, additional, Giordano, Raffaele, additional, Kai, Keita, additional, Amedei, Amedeo, additional, Lippi, Giuseppe, additional, Sugimura, Haruhiko, additional, Brandi, Giovanni, additional, Tavolari, Simona, additional, Gao, Peiyang, additional, and Zhang, Song, additional

Published
2023
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35. Intensive Follow-Up Program and Oncological Outcomes of Biliary Tract Cancer Patients after Curative-Intent Surgery: A Twenty-Year Experience in a Single Tertiary Medical Center

Author

Rizzo, Alessandro, primary, Carloni, Riccardo, additional, Frega, Giorgio, additional, Palloni, Andrea, additional, Di Federico, Alessandro, additional, Ricci, Angela Dalia, additional, De Luca, Raffaele, additional, Tavolari, Simona, additional, and Brandi, Giovanni, additional

Published
2022
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36. BARX2/FOXA1/HK2 axis promotes lung adenocarcinoma progression and energy metabolism reprogramming

Author

Xie, Kai, primary, Feng, Jian, additional, Fan, Dingwei, additional, Wang, Shi, additional, Luo, Jing, additional, Ren, Zhijian, additional, Zheng, Chao, additional, Diao, Yifei, additional, De Mello, Ramon Andrade, additional, Tavolari, Simona, additional, Brandi, Giovanni, additional, Roden, Anja C., additional, Ren, Binhui, additional, Shen, Yi, additional, and Xu, Lin, additional

Published
2022
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37. Immunotherapy in Pancreatic Cancer: Why Do We Keep Failing? A Focus on Tumor Immune Microenvironment, Predictive Biomarkers and Treatment Outcomes

Author

Di Federico, Alessandro, primary, Mosca, Mirta, additional, Pagani, Rachele, additional, Carloni, Riccardo, additional, Frega, Giorgio, additional, De Giglio, Andrea, additional, Rizzo, Alessandro, additional, Ricci, Dalia, additional, Tavolari, Simona, additional, Di Marco, Mariacristina, additional, Palloni, Andrea, additional, and Brandi, Giovanni, additional

Published
2022
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43. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

Author

Sansone, Pasquale, Storci, Gianluca, Tavolari, Simona, Guarnieri, Tiziana, Giovannini, Catia, Taffurelli, Mario, Ceccarelli, Claudio, Santini, Donatella, Paterini, Paola, Marcu, Kenneth B., Chieco, Pasquale, and Bonafe, Massimiliano

Subjects
Breast cancer -- Genetic aspects, Breast cancer -- Research, Gene expression -- Research, Interleukin-6 -- Health aspects, Interleukin-6 -- Research
Abstract

High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However, no data are available on the relationship between IL-6 and mammary stem/progenitor cells, which may fuel the genesis of breast cancer in vivo. Herein, we address this issue in the MCF-7 breast cancer cell line and in primary human mammospheres (MS), multicellular structures enriched in stem/progenitor cells of the mammary gland. MS from node invasive breast carcinoma tissues expressed IL-6 mRNA at higher levels than did MS from matched nonneoplastic mammary glands. In addition, IL-6 mRNA was detected only in basal-like breast carcinoma tissues, an aggressive breast carcinoma variant showing stem cell features. IL-6 treatment triggered Notch-3-dependent upregulation of the Notch ligand Jagged-1 and promotion of MS and MCF-7-derived spheroid growth. Moreover, IL-6 induced Notch-3-dependent upregulation of the carbonic anhydrase IX gene and promoted a hypoxia-resistant/invasive phenotype in MCF-7 cells and MS. Finally, autocrine IL-6 signaling relied upon Notch-3 activity to sustain the aggressive features of MCF-7-derived hypoxia-selected cells. In conclusion, these data support the hypothesis that IL-6 induces malignant features in Notch-3-expressing stem/progenitor cells from human ductal breast carcinoma and normal mammary gland., Introduction IL-6, a major mediator of the inflammatory response, plays a primary role in the pathophysiology of cancer (1), (2). In breast cancer patients, the extent of the increase in [...]

Published
2007

44. Immunomodulation by 17[beta]-estradiol in bivalve hemocytes

Author

Canesi, Laura, Ciacci, Caterina, Lorusso, Lucia Cecilia, Betti, Michele, Guarnieri, Tiziana, Tavolari, Simona, and Gallo, Gabriella

Subjects
Estrogen -- Research, Mytilus edulis -- Physiological aspects, Mytilus edulis -- Research, Biological sciences
Abstract

In mammals, estrogens have dose- and cell-type-specific effects on immune cells and may act as pro- and anti-inflammatory stimuli, depending on the setting. In the bivalve mollusc Mytilus, the natural estrogen 17[beta]-estradiol ([E.sub.2]) has been shown to affect neuroimmune functions. We have investigated the immunomodulatory role of [E.sub.2] in Mytilus hemocytes, the cells responsible for the innate immune response. [E.sub.2] at 5-25 nM rapidly stimulated phagocytosis and oxyradical production in vitro; higher concentrations of [E.sub.2] inhibited phagocytosis. [E.sub.2]-induced oxidative burst was prevented by the nitric oxide (NO) synthase inhibitor [N.sup.G]-monomethyl-L-arginine and superoxide dismutase, indicating involvement of NO and [O.sup.-.sub.2]; NO production was confirmed by nitrite accumulation. The effects of [E.sub.2] were prevented by the antiestrogen tamoxifen and by specific kinase inhibitors, indicating a receptor-mediated mechanism and involvement of p38 MAPK and PKC. [E.sub.2] induced rapid and transient increases in the phosphorylation state of PKC, as well as of a aCREB-like (cAMP responsive element binding protein) transcription factor, as indicated by Western blot analysis with specific anti-phospho-antibodies. Localization of estrogen receptor-[alpha]- and -[beta]-like proteins in hemocytes was investigated by immunofluorescence confocal microscopy. The effects of [E.sub.2] on immune function were also investigated in vivo at 6 and 24 h in hemocytes of [E.sub.2]-injected mussels. [E.sub.2] significantly affected hemocyte lysosomal membrane stability, phagocytosis, and extracellular release of hydrolytic enzymes: lower concentrations of [E.sub.2] resulted in immunostimulation, and higher concentrations were inhibitory. Our data indicate that the physiological role of [E.sub.2] in immunomodulation is conserved from invertebrates to mammals. estrogen; innate immunity; kinase-mediated cell signaling; Mytilus doi: 10.1152/ajpregu.00139.2006.

Published
2006

49. PARP Inhibitors in Biliary Tract Cancer: A New Kid on the Block?

Author

Ricci, Angela Dalia, primary, Rizzo, Alessandro, additional, Bonucci, Chiara, additional, Tober, Nastassja, additional, Palloni, Andrea, additional, Mollica, Veronica, additional, Maggio, Ilaria, additional, Deserti, Marzia, additional, Tavolari, Simona, additional, and Brandi, Giovanni, additional

Published
2020
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50. Evolution of the Experimental Models of Cholangiocarcinoma

Author

Massa, Annamaria, primary, Varamo, Chiara, additional, Vita, Francesca, additional, Tavolari, Simona, additional, Peraldo-Neia, Caterina, additional, Brandi, Giovanni, additional, Rizzo, Alessandro, additional, Cavalloni, Giuliana, additional, and Aglietta, Massimo, additional

Published
2020
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