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Purpose: To report a posterior segment phenotypic manifestation of Coxsackie virus infection that has not been previously appreciated. Methods: The clinical course and multimodal imaging findings, including spectral domain optical coherence tomography, fluorescein angiography, near infrared reflectance, and fundus autofluorescence of two patients with Coxsackie virus infections were documented. Results: A neurosensory macular detachment was present in both patients on baseline examination. Fluorescein angiography demonstrated pooling within this lesion and spectral domain optical coherence tomography identified thickening of the retinal pigment epithelial band with variable degrees of attenuation of the ellipsoid zone and interdigitation zone. Fundus autofluorescence and near infrared reflectance imaging revealed multiple satellite lesions adjacent to the neurosensory detachment. These lesions were not seen on fluorescein angiography or color photography. Satellite lesions were hyporeflective on near infrared reflectance imaging and hyperautofluorescent on fundus autofluorescence imaging. The satellite lesions correlated with sites of ellipsoid disruption on spectral domain optical coherence tomography. Both patients were observed and their condition improved over the course of time. There was total resolution of satellite lesions, reconstitution of the ellipsoid zone and interdigitation zone, and return of retinal pigment epithelial thickness to the normal range. A bull's eye pattern of macular retinal pigment epithelial disturbance persisted on color and near infrared reflectance images, despite good visual acuity. Conclusion: Posterior segment Coxsackie virus infection may concurrently express the clinical characteristics of acute idiopathic maculopathy and multifocal retinitis. The visual prognosis in this variant is usually favorable. The multimodal imaging features that characterize this entity should be recognized to avoid confusion with other diseases that have a similar presentation. [ABSTRACT FROM AUTHOR]

The article challenges the reader to diagnose an actual case based on clinical findings. It involves a 12-year-old boy who presented with a complaint of his left eye moving gradually downward over a one-month period. Topics include symptoms and results of his examination which included his visual acuity, motility in both eyes and normal posterior segments of both eyes. A discussion of the diagnosis, identified as Langerhans cell histiocytosis, its prognosis, and its treatment is presented.

The article describes the case of an 18-year-old woman diagnosed with focal disruption of outer retina. Topics include decreased best-corrected visual acuity in the right eye, afferent pupillary defect, and thickening at the level of the retinal pigment epithelium and trace subretinal fluid. Also mentioned are color vision, macular whitening, and unilateral acute idiopathic maculopathy.

The article presents the case of a 45-year-old woman with new onset adrk curtain and flashing lights affecting her right eye. Her medical history shows anti-phospho-lipid syndrome, hypertension and Nocardia and she diagnosed withherpes zoster ophthalmicus with corneal involvement. Her treatment shows that the most common culprits are varicella zoster virus followed by HSV-1 and HSV-2.

The article discusses the case of a 68-year-old man who complained of intermittent foggy vision in both eyes and increased photosensitivity. The patient's medical history is provided as well as his medications for diabetes mellitus. Results of several examinations performed on the patients are discussed including anterior segment and fluorescein angiography. The differential diagnosis of white-centered retinal hemorrhages is discussed.

The article presents a case study of a 40-year-old woman who presented with decreased vision and a retinal lesion in her left eye. The patient’s blood cultures were obtained. Vitreous biopsy revealed acute and chronic inflammatory cells with fungi present; pseudohyphae without septations and a wide-angle branching pattern that were characteristic of Candida indicating systemic candidemia were observed; intravenous broad-spectrum antibiotics and antifungals were given.