245 results on '"Taylor, Amelia"'
Search Results
2. Detection of Alzheimer’s disease using pre-trained deep learning models through transfer learning: a review
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Heenaye-Mamode Khan, Maleika, Reesaul, Pushtika, Auzine, Muhammad Muzzammil, and Taylor, Amelia
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- 2024
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3. MasakhaPOS: Part-of-Speech Tagging for Typologically Diverse African Languages
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Dione, Cheikh M. Bamba, Adelani, David, Nabende, Peter, Alabi, Jesujoba, Sindane, Thapelo, Buzaaba, Happy, Muhammad, Shamsuddeen Hassan, Emezue, Chris Chinenye, Ogayo, Perez, Aremu, Anuoluwapo, Gitau, Catherine, Mbaye, Derguene, Mukiibi, Jonathan, Sibanda, Blessing, Dossou, Bonaventure F. P., Bukula, Andiswa, Mabuya, Rooweither, Tapo, Allahsera Auguste, Munkoh-Buabeng, Edwin, Koagne, victoire Memdjokam, Kabore, Fatoumata Ouoba, Taylor, Amelia, Kalipe, Godson, Macucwa, Tebogo, Marivate, Vukosi, Gwadabe, Tajuddeen, Elvis, Mboning Tchiaze, Onyenwe, Ikechukwu, Atindogbe, Gratien, Adelani, Tolulope, Akinade, Idris, Samuel, Olanrewaju, Nahimana, Marien, Musabeyezu, Théogène, Niyomutabazi, Emile, Chimhenga, Ester, Gotosa, Kudzai, Mizha, Patrick, Agbolo, Apelete, Traore, Seydou, Uchechukwu, Chinedu, Yusuf, Aliyu, Abdullahi, Muhammad, and Klakow, Dietrich
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Computer Science - Computation and Language - Abstract
In this paper, we present MasakhaPOS, the largest part-of-speech (POS) dataset for 20 typologically diverse African languages. We discuss the challenges in annotating POS for these languages using the UD (universal dependencies) guidelines. We conducted extensive POS baseline experiments using conditional random field and several multilingual pre-trained language models. We applied various cross-lingual transfer models trained with data available in UD. Evaluating on the MasakhaPOS dataset, we show that choosing the best transfer language(s) in both single-source and multi-source setups greatly improves the POS tagging performance of the target languages, in particular when combined with cross-lingual parameter-efficient fine-tuning methods. Crucially, transferring knowledge from a language that matches the language family and morphosyntactic properties seems more effective for POS tagging in unseen languages., Comment: Accepted to ACL 2023 (Main conference)
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- 2023
4. Predicting School Dropout in Malawi
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Hara, Mudaniso, Taylor, Amelia, Gawanani, Precious, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Crawford, David, editor, Foss, Jeremy, editor, Lambert, Nicholas, editor, Reed, Martin, editor, and Kriebel, Jennah, editor
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- 2024
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5. MasakhaNER 2.0: Africa-centric Transfer Learning for Named Entity Recognition
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Adelani, David Ifeoluwa, Neubig, Graham, Ruder, Sebastian, Rijhwani, Shruti, Beukman, Michael, Palen-Michel, Chester, Lignos, Constantine, Alabi, Jesujoba O., Muhammad, Shamsuddeen H., Nabende, Peter, Dione, Cheikh M. Bamba, Bukula, Andiswa, Mabuya, Rooweither, Dossou, Bonaventure F. P., Sibanda, Blessing, Buzaaba, Happy, Mukiibi, Jonathan, Kalipe, Godson, Mbaye, Derguene, Taylor, Amelia, Kabore, Fatoumata, Emezue, Chris Chinenye, Aremu, Anuoluwapo, Ogayo, Perez, Gitau, Catherine, Munkoh-Buabeng, Edwin, Koagne, Victoire M., Tapo, Allahsera Auguste, Macucwa, Tebogo, Marivate, Vukosi, Mboning, Elvis, Gwadabe, Tajuddeen, Adewumi, Tosin, Ahia, Orevaoghene, Nakatumba-Nabende, Joyce, Mokono, Neo L., Ezeani, Ignatius, Chukwuneke, Chiamaka, Adeyemi, Mofetoluwa, Hacheme, Gilles Q., Abdulmumin, Idris, Ogundepo, Odunayo, Yousuf, Oreen, Ngoli, Tatiana Moteu, and Klakow, Dietrich
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Computer Science - Computation and Language - Abstract
African languages are spoken by over a billion people, but are underrepresented in NLP research and development. The challenges impeding progress include the limited availability of annotated datasets, as well as a lack of understanding of the settings where current methods are effective. In this paper, we make progress towards solutions for these challenges, focusing on the task of named entity recognition (NER). We create the largest human-annotated NER dataset for 20 African languages, and we study the behavior of state-of-the-art cross-lingual transfer methods in an Africa-centric setting, demonstrating that the choice of source language significantly affects performance. We show that choosing the best transfer language improves zero-shot F1 scores by an average of 14 points across 20 languages compared to using English. Our results highlight the need for benchmark datasets and models that cover typologically-diverse African languages., Comment: Accepted to EMNLP 2022 (updated Github link)
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- 2022
6. AI4D -- African Language Program
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Siminyu, Kathleen, Kalipe, Godson, Orlic, Davor, Abbott, Jade, Marivate, Vukosi, Freshia, Sackey, Sibal, Prateek, Neupane, Bhanu, Adelani, David I., Taylor, Amelia, ALI, Jamiil Toure, Degila, Kevin, Balogoun, Momboladji, DIOP, Thierno Ibrahima, David, Davis, Fourati, Chayma, Haddad, Hatem, and Naski, Malek
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Computer Science - Computation and Language - Abstract
Advances in speech and language technologies enable tools such as voice-search, text-to-speech, speech recognition and machine translation. These are however only available for high resource languages like English, French or Chinese. Without foundational digital resources for African languages, which are considered low-resource in the digital context, these advanced tools remain out of reach. This work details the AI4D - African Language Program, a 3-part project that 1) incentivised the crowd-sourcing, collection and curation of language datasets through an online quantitative and qualitative challenge, 2) supported research fellows for a period of 3-4 months to create datasets annotated for NLP tasks, and 3) hosted competitive Machine Learning challenges on the basis of these datasets. Key outcomes of the work so far include 1) the creation of 9+ open source, African language datasets annotated for a variety of ML tasks, and 2) the creation of baseline models for these datasets through hosting of competitive ML challenges.
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- 2021
7. Efficacy and safety of ‘Second Adjuvant’ therapy with BRAF/MEK inhibitors after local therapy for recurrent melanoma following adjuvant PD-1 based immunotherapy
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Taylor, Amelia M., McKeown, Janet, Dimitriou, Florentia, Jacques, Sarah K., Zimmer, Lisa, Allayous, Clara, Yeoh, Hui-Ling, Haydon, Andrew, Ressler, Julia M., Galea, Claire, Woodford, Rachel, Kahler, Katharina, Hauschild, Axel, Festino, Lucia, Hoeller, Christoph, Schwarze, Julia K., Neyns, Bart, Wicky, Alexandre, Michielin, Olivier, Placzke, Joanna, Rutkowski, Piotr, Johnson, Douglas B., Lebbe, Celeste, Dummer, Reinhard, Ascierto, Paolo A., Lo, Serigne, Long, Georgina V., Carlino, Matteo S., and Menzies, Alexander M.
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- 2024
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8. Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records
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Joseph, Rebecca M., Knaggs, Roger D., Coupland, Carol A. C., Taylor, Amelia, Vinogradova, Yana, Butler, Debbie, Gerrard, Louisa, Waldram, David, Iyen, Barbara, Akyea, Ralph K., Ashcroft, Darren M., Avery, Anthony J., and Jack, Ruth H.
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- 2023
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9. Towards a machine understanding of Malawi legal text
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Taylor, Amelia V. and Mfutso-Bengo, Eva
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- 2023
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10. The effect of using entry-level keyboards in improving user-adaptability to new keyboards: Case of the Central-Bantu keyboards
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Chimkono, Thokozani, Taylor, Amelia, Mphako-Banda, Eunice, and Kishindo, Pascal
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- 2023
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11. BRAF inhibitor cessation prior to disease progression in metastatic melanoma: Long-term outcomes
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Lee, Joanna, Ahmed, Tasnia, Maurichi, Andrea, Di Guardo, Lorenza, Stagno, Anna M., Warburton, Lydia, Taylor, Amelia. M., Livingstone, Elisabeth, Rehman, Saba, Khattak, Adnan, Kahler, Katharina C., Vanella, Vito, Atkinson, Victoria, Millward, Michael, Schadendorf, Dirk, Johnson, Douglas B., Ascierto, Paolo A., Hauschild, Axel, Lo, Serigne N., Long, Georgina V., Menzies, Alexander M., and Carlino, Matteo S.
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- 2023
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12. An Enhanced Deep Neural Network Model for the Detection of Anomalous Behavior of Drivers in Road Traffic.
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Khan, Maleika Heenaye-Mamode, Nagwanshi, Kapil Kumar, Muhammad Azhar, Bhuheekhan, Girish, Emerith, Baichoo, Sunilduth, Sinha, G. R., Taylor, Amelia, and Thotagamuge, Roshan
- Abstract
Over recent years, video‐surveillance systems have seen extensive adoption, largely driven by security imperatives, with radar‐based speed detection being a common feature in traffic monitoring. Despite its prevalence, broader anomaly detection in traffic patterns has not received equivalent focus. This research develops a sophisticated deep learning framework, drawing architectural inspiration from MobileNet, ResNet50, and VGG19, to not only detect and track vehicles but also analyze trajectory data to identify nonstandard behaviors. Specifically, our model detects four distinct anomalies: overspeeding, lingering in no‐stopping zones, insufficient spacing between vehicles, and violations of traffic light signals. To support this, we constructed a unique dataset comprising over 60,000 video frames. The YOLOv3 algorithm facilitated initial object recognition, which was complemented by data augmentation techniques to mitigate issues related to class imbalance and the limited availability of annotated datasets in this domain. Our enhanced model achieved an overall accuracy of 95%, with a detailed performance breakdown for each detected anomaly. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Investigating the factors affecting adherence to inhaled corticosteroids in patients with asthma using primary care data in the UK
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Taylor, Amelia C.
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362.1962 ,QP501 Animal biochemistry ,R Medicine (General) - Abstract
Background: Poor adherence to inhaled corticosteroids (ICS) is known as the main cause for therapeutic failure in asthma treatment and associated morbidity. Adherence is complex and can have many causes, which will vary between conditions, treatments and patients. To improve adherence, it is vital to understand what effects a patients adherence, so appropriate interventions can be developed and targeted, both for the patients who would benefit most and at the most important points in treatment. Very few studies have characterised the variables associated with poor adherence and how these differences may change over time, and the most appropriate methodology for investigating this relations have not previously been defined. Aims and objectives: The aim of the PhD study was to investigate what characteristics associated with a patient’s adherence to ICS, and to investigate whether these relationships change over time using a large primary care dataset. The objectives included the development of a longitudinal measure of asthma patients’ adherence to ICS, then to investigate the time dependent relationship between adherence and other available patient variables by trialling a number of different methods. In addition, the effect of adherence on clinical outcome in asthma was tested, since counter intuitively many studies have not previously found a clear relationship between the variables. Methods: A retrospective longitudinal study using a large cohort was conducted using primary care data from the Clinical Practice Research Datalink (with Hospital Episodes Statistics data) between 1997 and 2010. Asthma patients aged between 12 and 65 years, without a diagnosis of chronic obstructive pulmonary disease were included in the study cohort. ICS prescriptions were extracted and used to calculate the annual prescription possession ratio (PPR). Several definitions of the PPR measure were tested to develop a proxy measure to represent adherence. Variables related to clinical outcomes and other characteristics were also identified for each patient in the cohort. A two-way analysis was conducted to compare the relationship between adherence and each patient variable with time, and then four methods were used to further investigate the relationship between adherence and patient exacerbations including; (1) comparing adherence in the year before and after an exacerbation; (2) descriptively exploring the clinical outcomes associated with different adherence levels; (3) identifying the relative risk of an exacerbation associated with adherence defined by different cut off levels of PPR; and (4) descriptively exploring the effect of adherence on outcome and outcome on adherence over time. Finally, the available variables associated with adherence (including previous adherence and clinical outcomes) were analysed in a dynamic panel model to understand explore the effect of variables on patients’ adherence to ICS which allows for the feedback effects of previous adherence and clinical outcome and the effect of time on adherence. Results: Many patient variables were found to effect adherence. When modelling the effect of patient variables on adherence, adherence was found to be lower in younger patients (+0.11%/year), patients with fewer years in the study (+0.25%/year), with more severe asthma (step 5 patients had a 3.32% lower PPR than step 2 patients), with good control (5.21% lower), with lower previous adherence (-0.51% per % PPR), and who had not previously experienced an exacerbation (0.87% lower compared with patients who had experienced no primary car exacerbation and 1.45% lower for those who experienced no secondary care exacerbation). Adherence increased with patient year, consistently across most subgroups, with the following exceptions; the 20-25 year old age group had lower initial adherence (53.9%) than the younger patients (58.3%), patients registered in the East Midlands had the lowest adherence (57.7%), but increased over time to become the highest (90.7%) and in the first year of the study the adherence for patients treated at step 2 of the guidelines was the lowest (57.5%) but it increased over time to become the second highest step (85.7%). Conclusion: This longitudinal follow-up study using electronic patient records over time was useful to identify the effect of multiple patient variables on adherence. The main characteristics associated with poor adherence were the characteristics that we would associate with better health, or less severe asthma. Therefore, the interventions to improve adherence or to review the appropriateness of treatment should be developed to target younger patients, early on in treatment before they have experienced an exacerbation of their asthma symptoms. The PPR measure developed was useful to measure changes in adherence over time, as a measure of the maximum amount of medicine that the patient had available to them, expressed as a percentage of their recorded prescribed dose. However there are some important limitations to the PPR measure including most importantly that adherence must be measured against a routinely prescribed daily dose of ICS and medicine prescribing and not medicine taking is measured, meaning that adherence is likely to be overestimated. The methods used to analyse the adherence measure had not previously been used to assess adherence in asthma. By using the results from each analysis method, information about different parts of the relationship between adherence and other patient variables including their exacerbation risk and time could be combined, which uniquely allowed the longitudinal measurement and analysis of adherence in asthma over extended study duration.
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- 2017
14. Substructures in large graphs
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Taylor, Amelia May
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511 ,QA Mathematics - Abstract
The first problem we address concerns Hamilton cycles. Suppose G is a large digraph in which every vertex has in- and outdegree at least |G|/2. We show that G contains every orientation of a Hamilton cycle except, possibly, the antidirected one. The antidirected case was settled by DeBiasio and Molla. Our result is best possible and improves on an approximate result by Häggkvist and Thomason. We then investigate the random greedy F-free process which was initially studied by Erdős, Suen and Winkler and by Spencer. This process greedily adds edges without creating a copy of F, terminating in a maximal F-free graph. We provide an upper bound on the number of hyperedges at the end of this process for a large class of hypergraphs. The remainder of this thesis focuses on F-decompositions, i.e., whether the edge set of a graph can be partitioned into copies of F. We obtain the best known bounds on the minimum degree which ensures a K\(_r\)-decomposition of an r-partite graph, with applications to Latin squares. Lastly, we find exact bounds on the minimum degree for a large graph to have a C\(_2\)\(_k\)-decomposition where k≠3. In both cases, we assume necessary divisibility conditions are satisfied.
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- 2017
15. Developing a statistically powerful measure for quartet tree inference using phylogenetic identities and Markov invariants
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Sumner, Jeremy G, Taylor, Amelia, Holland, Barbara R, and Jarvis, Peter D
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Quantitative Biology - Quantitative Methods ,Mathematics - Algebraic Geometry ,Mathematics - Representation Theory ,Quantitative Biology - Populations and Evolution - Abstract
Recently there has been renewed interest in phylogenetic inference methods based on phylogenetic invariants, alongside the related Markov invariants. Broadly speaking, both these approaches give rise to polynomial functions of sequence site patterns that, in expectation value, either vanish for particular evolutionary trees (in the case of phylogenetic invariants) or have well understood transformation properties (in the case of Markov invariants). While both approaches have been valued for their intrinsic mathematical interest, it is not clear how they relate to each other, and to what extent they can be used as practical tools for inference of phylogenetic trees. In this paper, by focusing on the special case of binary sequence data and quartets of taxa, we are able to view these two different polynomial-based approaches within a common framework. To motivate the discussion, we present three desirable statistical properties that we argue any phylogenetic method should satisfy: (1) sensible behaviour under reordering of input sequences; (2) stability as the taxa evolve independently according to a Markov process; and (3) ability to detect if the conditions of a continuous-time process are violated. Motivated by these statistical properties, we develop and explore several new phylogenetic inference methods. In particular, we develop a statistical bias-corrected version of the Markov invariants approach which satisfies all three properties. We also extend previous work by showing that the phylogenetic invariants can be implemented in such a way as to satisfy property (3). A simulation study shows that, in comparison to other methods, our new proposed approach based on bias-corrected Markov invariants is extremely powerful for phylogenetic inference., Comment: 27 pages; 5 figures (now colour); 7 tables. Updated in line with reviewer comments
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- 2016
16. On the exact decomposition threshold for even cycles
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Taylor, Amelia
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Mathematics - Combinatorics - Abstract
A graph $G$ has a $C_k$-decomposition if its edge set can be partitioned into cycles of length $k$. We show that if $\delta(G)\geq 2|G|/3-1$, then $G$ has a $C_4$-decomposition, and if $\delta(G)\geq |G|/2$, then $G$ has a $C_{2k}$-decomposition, where $k\in \mathbb{N}$ and $k\geq 4$ (we assume $G$ is large and satisfies necessary divisibility conditions). These minimum degree bounds are best possible and provide exact versions of asymptotic results obtained by Barber, K\"uhn, Lo and Osthus. In the process, we obtain asymptotic versions of these results when $G$ is bipartite or satisfies certain expansion properties.
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- 2016
17. Clique decompositions of multipartite graphs and completion of Latin squares
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Barber, Ben, Kühn, Daniela, Lo, Allan, Osthus, Deryk, and Taylor, Amelia
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Mathematics - Combinatorics - Abstract
Our main result essentially reduces the problem of finding an edge-decomposition of a balanced r-partite graph of large minimum degree into r-cliques to the problem of finding a fractional r-clique decomposition or an approximate one. Together with very recent results of Bowditch and Dukes as well as Montgomery on fractional decompositions into triangles and cliques respectively, this gives the best known bounds on the minimum degree which ensures an edge-decomposition of an r-partite graph into r-cliques (subject to trivially necessary divisibility conditions). The case of triangles translates into the setting of partially completed Latin squares and more generally the case of r-cliques translates into the setting of partially completed mutually orthogonal Latin squares., Comment: 40 pages. To appear in Journal of Combinatorial Theory, Series A
- Published
- 2016
18. National Experiential v. Chicago: Free Speech, Zoning, a Fight Over Commercial Displays, and the NBA All-Star Game.
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Taylor, Amelia
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- 2024
19. On the random greedy F-free hypergraph process
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Kühn, Daniela, Osthus, Deryk, and Taylor, Amelia
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Mathematics - Combinatorics - Abstract
Let $F$ be a strictly $k$-balanced $k$-uniform hypergraph with $e(F)\geq |F|-k+1$ and maximum co-degree at least two. The random greedy $F$-free process constructs a maximal $F$-free hypergraph as follows. Consider a random ordering of the hyperedges of the complete $k$-uniform hypergraph $K_n^k$ on $n$ vertices. Start with the empty hypergraph on $n$ vertices. Successively consider the hyperedges $e$ of $K_n^k$ in the given ordering, and add $e$ to the existing hypergraph provided that $e$ does not create a copy of $F$. We show that asymptotically almost surely this process terminates at a hypergraph with $\tilde{O}(n^{k-(|F|-k)/(e(F)-1)})$ hyperedges. This is best possible up to logarithmic factors.
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- 2015
20. Evaluating a large-scale rollout of a pharmacist-led information technology intervention (PINCER) in English general practice
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Taylor, Amelia, Avery, Anthony, Roberts, Steve, Ashcroft, Darren, Rodgers, Sarah, Elliott, Rachel, and Allen, Thomas
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Pharmacists -- Practice ,Cost benefit analysis -- Methods ,Drug therapy -- Methods ,Physicians (General practice) -- Services ,Cost benefit analysis ,Health ,Science and technology - Abstract
Context: We previously reported the effectiveness and cost-effectiveness of a pharmacist-led information technology intervention (PINCER) at reducing hazardous prescribing. The PINCER intervention searches GP clinical systems to identify patients at risk of hazardous prescribing, identified by 11 prescribing safety indicators, and with pharmacist support the practice acts to correct the prescribing to minimise future risk. Objective: To evaluate the effectiveness of PINCER when widely implemented in general practices on the prevalence of patient exposure to hazardous prescribing and also on the incidence of serious harm in patients at risk of hazardous prescribing. Study Design and Analysis: The PINCER intervention was rolled out in 370 general practices using a non-randomised multicentre incomplete stepped-wedge study design whereby the intervention was introduced to successive groups of general practices between Sept 2015 and Apr 2017. Data was extracted from 115 of these practices between Feb 2013 and Aug 2019. We used the indicators to identify potentially hazardous prescribing and collected data over a maximum of 16 quarterly time periods around the times of implementation. Modelling of each hazardous prescribing indicator and serious harm outcome, and composite indicators utilised a mixed model approach, with logistic mixed models for the quarterly event numbers with the appropriate denominator. Setting or Dataset: Data extracted directly from GP systems. Population Studied: Practices who had implemented PINCER in the East Midlands, England. Intervention/Instrument: PINCER. Outcome Measures: The proportion of patients in each practice and quarter exposed to at least one type of hazardous prescribing, identified using the prescribing safety indicators, and the proportion of patients with serious harm. Results: The PINCER intervention was associated with a decrease in the rate of hazardous prescribing at 6 months, 12 months and 24 months post-intervention. A reduction in deaths and all cause hospitalisation were observed post intervention. However, a less clear association between the PINCER intervention and serious harm outcomes (identified within primary care data) were observed. Detailed results will be presented. Conclusions: We demonstrate the real-world effectiveness of the PINCER intervention in reducing exposure to potentially hazardous medication when rolled out at scale in UK general practices, where the reductions were sustained for up to 24 months., Presenters Amelia Taylor, PhD, BSc, Anthony Avery, MD, FRCGP, FRCPC, MBChB, DM, Steve Roberts, PhD, Darren Ashcroft, Sarah Rodgers, PhD, BSc, Rachel Elliott, PhD, BPharm, FRPharmS, Thomas Allen, PhD, BSc, [...]
- Published
- 2023
21. Impact of Social Stories on social and emotional health of autism spectrum primary school children: the ASSSIST2 RCT with economic evaluation.
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Wright, Barry, Bell, Kerry Jane, Blackwell, Jane E, Teige, Catarina, Mandefield, Laura, Wang, Han I, Welch, Charlie, Scantlebury, Arabella, Watson, Jude, McMillan, Dean, Standley, Emma, Attwell, Leah, Carrick, Hayley, Taylor, Amelia, Taylor, Olivia, Hodkinson, Rachel, Edwards, Hannah, Pearson, Hannah, Parrott, Steve, and Marshall, David
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- 2024
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22. Safety Nets: A Social Prescribing Intervention to Support Young People on CAMHS Waiting Lists.
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Garside, Megan, Taylor, Amelia, Dias, Ryan, Powell, Lauren, Parker, Jack, Fenton, Clare, and Roscoe, Clare M. P.
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CHILD mental health services , *YOUNG adults , *PSYCHOEDUCATION , *PHYSICAL activity , *ATHLETIC clubs - Abstract
AbstractHigh numbers of children face mental health difficulties in the UK, leading to increased referrals to Child and Adolescent Mental Health Services (CAMHS) which face reduced capacity and increased waiting times. Children’s mental health can deteriorate significantly during this wait for treatment. Safety Nets is an 8-week group intervention for children on CAMHS waiting lists, involving psychoeducation and physical activity co-delivered by clinicians and coaches at local sports clubs. A mixed-methods feasibility study was conducted exploring the impact of Safety Nets. A fully powered trial is now needed to further test for clinical and cost-effectiveness and to support future implementation. [ABSTRACT FROM AUTHOR]
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- 2024
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23. A Systematic Review of the Use, Acceptability, Perceived Effectiveness and Effectiveness of Self-Help Toolkits.
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Fenton, Clare, Holmes, Jannah, Taylor, Amelia, and Jackson, Zoe
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SELF-injurious behavior ,HEALTH self-care ,AMED (Information retrieval system) ,MEDICAL information storage & retrieval systems ,EMOTION regulation ,SELF-efficacy ,EVALUATION of medical care ,HELP-seeking behavior ,REFLECTION (Philosophy) ,SYSTEMATIC reviews ,MEDLINE ,THEMATIC analysis ,CREATIVE ability ,HEALTH behavior ,DISTRACTION ,GROUNDED theory ,INTERPERSONAL relations ,SELF-consciousness (Awareness) ,PSYCHOLOGY information storage & retrieval systems ,HOPE ,RELAXATION for health - Abstract
Self-harming behaviours can include cutting the skin, ligaturing and taking overdoses. These actions can result in infection, blood loss, or even death. A young person's risk of dying by suicide increases if they engage in self-harm. Self-help empowers people to utilise different coping strategies and implement life changes without reliance on a clinical intervention, "helping people to help themselves". Self-help toolkits contain a variety of items that are selected by the person to help them manage the urge to self-harm. The items included sensory objects, distractions, prompts to seek help and creative prompts such as colouring books and pens and personal items that trigger positive memories. AMED, EMBASE, APA Psycinfo and MEDLINE were searched with no language restriction or date restriction. Of the 368 studies screened, 13 met the inclusion criteria. The studies were mainly small scale or case studies pertaining to the use of self-help toolkits or similar. They described the need for a flexible and/or individualised approach to self-help toolkits. Abstracts and studies were screened separately by two members of the research team for inclusion. Qualitative data was analysed using Grounded Theory. Nine themes were identified: Creativity, Hope, Social contact/help seeking, calming/relaxing, sensory items, reflection, distractions, therapeutic prompts and emotional release. Self-efficacy and self-awareness were the two main mechanisms identified. Self-help toolkits were found to be acceptable and helpful, but the limited evidence base means their efficacy for reducing self-harm episodes has not been established. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Value-based decision-making in regular cannabis users and non-users: A proof-of-concept study
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Taylor, Amelia J, primary and Copeland, Amber, additional
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- 2024
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25. Arbitrary Orientations of Hamilton Cycles in Digraphs
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DeBiasio, Louis, Kühn, Daniela, Molla, Theodore, Osthus, Deryk, and Taylor, Amelia
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Mathematics - Combinatorics - Abstract
Let $n$ be sufficiently large and suppose that $G$ is a digraph on $n$ vertices where every vertex has in- and outdegree at least $n/2$. We show that $G$ contains every orientation of a Hamilton cycle except, possibly, the antidirected one. The antidirected case was settled by DeBiasio and Molla, where the threshold is $n/2+1$. Our result is best possible and improves on an approximate result by H\"aggkvist and Thomason., Comment: Final version, to appear in SIAM Journal Discrete Mathematics (SIDMA)
- Published
- 2014
26. The regularity method for graphs and digraphs
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Taylor, Amelia
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Mathematics - Combinatorics - Abstract
This MSci thesis surveys results in extremal graph theory, in particular relating to Hamilton cycles. Szem\'eredi's Regularity Lemma plays a central role. We also investigate the robust outexpansion property for digraphs. Kelly showed that every sufficiently large oriented graph on $n$ vertices with minimum in- and outdegree at least $3n/8 +o(n)$ contains any orientation of a Hamilton cycle. We use Kelly's arguments to extend his result to any robustly expanding digraph of linear degree., Comment: MSci Thesis
- Published
- 2014
27. The Structure of N-Player Games when Influence and Independence Collide
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Steel, Mike and Taylor, Amelia
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Mathematics - Probability - Abstract
We study the mathematical properties of probabilistic processes in which the independent actions of $n$ players (`causes') can influence the outcome of each player (`effects'). In such a setting, each pair of outcomes will generally be statistically correlated, even if the actions of all the players provide a complete causal description of the players' outcomes, and even if we condition on the outcome of any one player's action. This correlation always holds when $n=2$, but when $n=3$ there exists a highly symmetric process, recently studied, in which each cause can influence each effect, and yet each pair of effects is probabilistically independent (even upon conditioning on any one cause). We study such symmetric processes in more detail, obtaining a complete classification for all $n \geq 3$. Using a variety of mathematical techniques, we describe the geometry and topology of the underlying probability space that allows independence and influence to coexist., Comment: 24 pages, 3 figures
- Published
- 2013
28. A semialgebraic description of the general Markov model on phylogenetic trees
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Allman, Elizabeth S., Rhodes, John A., and Taylor, Amelia
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Quantitative Biology - Populations and Evolution ,Mathematics - Algebraic Geometry ,Mathematics - Statistics Theory ,60J20, 92D15, 92D20, 62P10, 14P10 - Abstract
Many of the stochastic models used in inference of phylogenetic trees from biological sequence data have polynomial parameterization maps. The image of such a map --- the collection of joint distributions for a model --- forms the model space. Since the parameterization is polynomial, the Zariski closure of the model space is an algebraic variety which is typically much larger than the model space, but has been usefully studied with algebraic methods. Of ultimate interest, however, is not the full variety, but only the model space. Here we develop complete semialgebraic descriptions of the model space arising from the k-state general Markov model on a tree, with slightly restricted parameters. Our approach depends upon both recently-formulated analogs of Cayley's hyperdeterminant, and the construction of certain quadratic forms from the joint distribution whose positive (semi-)definiteness encodes information about parameter values. We additionally investigate the use of Sturm sequences for obtaining similar results., Comment: 29 pages, 0 figures; Mittag-Leffler Institute, Spring 2011
- Published
- 2012
29. Minimal primes of ideals arising from conditional independence statements
- Author
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Swanson, Irena and Taylor, Amelia
- Subjects
Mathematics - Commutative Algebra ,13P10, 13P25 - Abstract
We consider ideals arising in the context of conditional independence models that generalize the class of ideals considered by Fink [7] in a way distinct from the generalizations of Herzog-Hibi-Hreinsdottir-Kahle-Rauh [13] and Ay-Rauh [1]. We introduce switchable sets to give a combinatorial description of the minimal prime ideals, and for some classes we describe the minimal components. We discuss many possible interpretations of the ideals we study, including as 2 \times 2 minors of generic hypermatrices. We also introduce a definition of diagonal monomial orders on generic hypermatrices and we compute some Groebner bases., Comment: We shortened and streamlined the paper from 24 to 17 pages, we improved several proofs, we updated references, and we added Groebner bases of certain ideals under t-diagonal orders on generic hypermatrices (a generalization of diagonal orders on variables in a generic matrix). The term "admissible" from previous versions is now changed to "switchable"
- Published
- 2011
30. Second symmetric powers of chain complexes
- Author
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Frankild, Anders J., Sather-Wagstaff, Sean, and Taylor, Amelia
- Subjects
Mathematics - Commutative Algebra ,13C10, 13D25 - Abstract
We investigate Buchbaum and Eisenbud's construction of the second symmetric power S^2_R(X) of a chain complex X of modules over a commutative ring R. We state and prove a number of results from the folklore of the subject for which we know of no good direct references. We also provide several explicit computations and examples. We use this construction to prove the following version of a result of Avramov, Buchweitz, and Sega: Let R \to S be a module-finite ring homomorphism such that R is noetherian and local, and such that 2 is a unit in R. Let X be a complex of finite rank free S-modules such that X_n = 0 for each n < 0. If \cup_n Ass_R(H_n(X \otimes_S X)) \subseteq Ass(R) and if X_P \simeq S_P for each P \in Ass(R), then X \simeq S., Comment: 25 pages, uses xypic. v.2: introduction revised, Theorem 3.1 generalized with part in new Corollary 3.2, and minor changes made throughout. v3: significantly rewritten, final version to appear in Bulletin of the Iranian Mathematical Society
- Published
- 2008
31. Relations between semidualizing complexes
- Author
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Frankild, Anders J., Sather-Wagstaff, Sean, and Taylor, Amelia
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Mathematics - Commutative Algebra ,13D05, 13D07, 13D25, 13H10 - Abstract
We study the following question: Given two semidualizing complexes B and C over a commutative noetherian ring R, does the vanishing of Ext^n_R(B,C) for n>>0 imply that B is C-reflexive? This question is a natural generalization of one studied by Avramov, Buchweitz, and Sega. We begin by providing conditions equivalent to B being C-reflexive, each of which is slightly stronger than the condition Ext^n_R(B,C)=0 for all n>>0. We introduce and investigate an equivalence relation \approx on the set of isomorphism classes of semidualizing complexes. This relation is defined in terms of a natural action of the derived Picard group and is well-suited for the study of semidualizing complexes over nonlocal rings. We identify numerous alternate characterizations of this relation, each of which includes the condition Ext^n_R(B,C)=0 for all n>>0. Finally, we answer our original question in some special cases., Comment: final version, to appear in J. Commutative Algebra, 27 pages, uses XY-pic
- Published
- 2007
32. A study of the effectiveness of self-video interventions on parent-child interaction and children's verbal communication skills and the experience of video interaction guidance for parents of children with communication difficulties
- Author
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Taylor, Amelia Fay
- Subjects
370.15 - Abstract
It is widely believed that positive parent-child interaction fosters child development. Interventions involving participants viewing videos of their own interactions (self- video interventions) can support the development of interaction skills. The systematic literature review focused on the effectiveness of self-video interventions on parent- child interaction and the verbal communication skills of children. The study focused on nine published, empirical studies. Findings suggested some positive outcomes relating to parents‘ interaction skills and aspects of children‘s expressive and receptive language skills. Whilst there is some evidence that self-video interventions can have a positive effect on parent-child interactions and children‘s verbal communication skills, less is known about the parental experience of self-video interventions (Lomas, 2011). One specific self-video intervention, video interaction guidance (VIG) was then investigated in a practitioner research project. The project aimed to uncover the parental experience of VIG. Three participants took part in one cycle of VIG and one interview with the researcher who was a trainee VIG guider. Interview data were analysed using Interpretive Phenomenological Analysis (IPA). The findings indicated parents valued the opportunity for reflection using video and they felt empowered to make positive changes in their relationships with their children through one cycle of VIG. The findings also raised questions about parents‘ experiences of control and feelings of being judged during VIG. Participants felt the VIG experience involved a degree of professional judgement of their parenting skills and their children‘s verbal communication skills. This is discussed within the wider socio-cultural context of practitioner-client relationships. Understanding of the function of the relationship between the guider and the VIG client was identified as a key area for future research.
- Published
- 2013
33. Borel Fixed Initial Ideals of Prime Ideals in Dimension Two
- Author
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Taylor, Amelia
- Subjects
Mathematics - Commutative Algebra ,13P10 - Abstract
We prove that if the initial ideal of a prime ideal is Borel-fixed and the dimension of the quotient ring is less than or equal to two, then given any non-minimal associated prime ideal of the initial ideal it contains another associated prime ideal of dimension one larger., Comment: 4 pages
- Published
- 2003
34. Methods for Computing Normalisations of Affine Rings
- Author
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Taylor, Amelia
- Subjects
Mathematics - Commutative Algebra ,Mathematics - Rings and Algebras ,13B22 - Abstract
Our main purpose is to give multiple examples for using the available implementations for computing the normalization of an affine ring, computing the minimial generators of the normalization as an algebra over the original ring and integral closures of ideals. Some such examples have been published for Singular, but not for Macaulay 2 and we present both in this paper. We also briefly describe the implementations., Comment: To Appear in "Advances in Algebra and Geometry (University of Hyderabad Conference 2001)" . Includes extensive examples. 17 pages
- Published
- 2003
35. Inverse Grobner Basis Problem in Codimension Two
- Author
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Taylor, Amelia
- Subjects
Mathematics - Commutative Algebra ,Mathematics - Algebraic Geometry - Abstract
Generic linkage is used to compute a prime ideal such that the radical of the initial ideal of the prime ideal is equal to the radical of a given codimension two monomial ideal that has a Cohen-Macaulay quotient ring., Comment: 18 pages, AMSLaTeX
- Published
- 2000
36. A unifying framework for Lambda Calculi and their extensions with explicit substitution operators that is useful for verifying confluence
- Author
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Taylor, Amelia V.
- Subjects
511.35 - Published
- 2006
37. Clique decompositions of multipartite graphs and completion of Latin squares
- Author
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Barber, Ben, Kühn, Daniela, Lo, Allan, Osthus, Deryk, and Taylor, Amelia
- Published
- 2017
- Full Text
- View/download PDF
38. INSPIRE datahub: a pan-African integrated suite of services for harmonising longitudinal population health data using OHDSI tools.
- Author
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Bhattacharjee, Tathagata, Sylvia Kiwuwa-Muyingo, Kanjala, Chifundo, Maoyi, Molulaqhooa L., Amadi, David, Ochola, Michael, Kadengye, Damazo, Gregory, Arofan, Kiragga, Agnes, Taylor, Amelia, Greenfield, Jay, Slaymaker, Emma, and Todd, Jim
- Subjects
POPULATION health ,DATA privacy ,MICROSOFT Azure (Computing platform) ,WEB services ,DATA science ,MIDDLE-income countries ,DATA security ,DATA integration - Abstract
Introduction: Population health data integration remains a critical challenge in low- and middle-income countries (LMIC), hindering the generation of actionable insights to inform policy and decision-making. This paper proposes a pan-African, Findable, Accessible, Interoperable, and Reusable (FAIR) research architecture and infrastructure named the INSPIRE datahub. This cloud-based Platform-as-a-Service (PaaS) and on-premises setup aims to enhance the discovery, integration, and analysis of clinical, population-based surveys, and other health data sources. Methods: The INSPIRE datahub, part of the Implementation Network for Sharing Population Information from Research Entities (INSPIRE), employs the Observational Health Data Sciences and Informatics (OHDSI) open-source stack of tools and the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) to harmonise data from African longitudinal population studies. Operating on Microsoft Azure and Amazon Web Services cloud platforms, and on on-premises servers, the architecture offers adaptability and scalability for other cloud providers and technology infrastructure. The OHDSI-based tools enable a comprehensive suite of services for data pipeline development, profiling, mapping, extraction, transformation, loading, documentation, anonymization, and analysis. Results: The INSPIRE datahub's "On-ramp" services facilitate the integration of data and metadata from diverse sources into the OMOP CDM. The datahub supports the implementation of OMOP CDM across data producers, harmonizing source data semantically with standard vocabularies and structurally conforming to OMOP table structures. Leveraging OHDSI tools, the datahub performs quality assessment and analysis of the transformed data. It ensures FAIR data by establishing metadata flows, capturing provenance throughout the ETL processes, and providing accessible metadata for potential users. The ETL provenance is documented in a machine- and human-readable Implementation Guide (IG), enhancing transparency and usability. Conclusion: The pan-African INSPIRE datahub presents a scalable and systematic solution for integrating health data in LMICs. By adhering to FAIR principles and leveraging established standards like OMOP CDM, this architecture addresses the current gap in generating evidence to support policy and decision-making for improving the well-being of LMIC populations. The federated research network provisions allow data producers to maintain control over their data, fostering collaboration while respecting data privacy and security concerns. A use-case demonstrated the pipeline using OHDSI and other open-source tools. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
39. How Do Parents of Children with Communication Difficulties Experience Video Interaction Guidance? A Practitioner Research Project
- Author
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Taylor, Amelia Fay
- Abstract
This practitioner research article sought to provide an interpretation of the parental experience of video interaction guidance (VIG). Two mothers and one grandmother participated in one cycle of VIG and one interview about their experiences. Transcripts were analysed using Interpretive Phenomenological Analysis (IPA). Findings indicated that parents valued the opportunity to use video to reflect on their interaction skills. They felt empowered to use their learning to develop relationships with their children. Questions emerged about parents' experiences of control and feeling judged during VIG. Participants' felt VIG involved some judgement of their parenting skills and their children's communication skills. This is discussed within the wider socio-cultural context of practitioner-client relationships. The article highlighted implications for VIG practitioners to be honest about their positions and mindful of the feelings of the clients they support. Understanding of the function of the relationship between the guider and the VIG client was identified as an area for future research.
- Published
- 2016
- Full Text
- View/download PDF
40. Enabling data sharing and utilization for African population health data using OHDSI tools with an OMOP-common data model
- Author
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Kiwuwa-Muyingo, Sylvia, primary, Todd, Jim, additional, Bhattacharjee, Tathagata, additional, Taylor, Amelia, additional, and Greenfield, Jay, additional
- Published
- 2023
- Full Text
- View/download PDF
41. Optimization of in situ growth nanoparticles on filter paper for saliva characterization via surface-enhanced Raman spectroscopy
- Author
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Taylor, Amelia, primary, Carroll, Braden, additional, and Locke, Andrea K., additional
- Published
- 2023
- Full Text
- View/download PDF
42. Metastatic primary breast neuroendocrine neoplasms: a case series.
- Author
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Batty, Kathleen, Taylor, Amelia M., Bernard, Elizabeth J., Diakos, Connie I., Clarke, Stephen J., Guminski, Alexander, Baron‐Hay, Sally, Boyle, Frances, Pavlakis, Nick, and Chan, David L.
- Subjects
- *
BREAST tumor treatment , *BREAST cancer prognosis , *CANCER chemotherapy , *METASTASIS , *RETROSPECTIVE studies , *ACQUISITION of data , *CANCER patients , *MOLECULAR biology , *NEUROENDOCRINE tumors , *CASE studies , *MEDICAL records , *POSITRON emission tomography , *HISTOLOGY , *PROGRESSION-free survival , *COMBINED modality therapy , *BREAST tumors , *OVERALL survival , *CANCER patient medical care , *SYMPTOMS - Abstract
Background: Breast neuroendocrine neoplasms represent a rare subtype of breast cancer which have not been well studied or characterised, particularly in the metastatic setting. Aim: To present clinicopathological characteristics, treatment and outcomes of a series of patients with metastatic neuroendocrine carcinoma of the breast and review the current literature. Methods: We performed a retrospective review to identify and describe patients with metastatic neuroendocrine carcinoma of the breast at our centre between 2011 and 2021. Medical records, pathology and imaging results were examined to evaluate the clinical and histopathological features as well as the treatment pathways and prognosis of these patients. Results: We present a series of seven female patients with metastatic neuroendocrine carcinoma of the breast, as defined by the World Health Organization classification, over a period of 10 years (2011–2021) from a single centre. Median age at diagnosis was 48 years (range 39–63). Six of seven tissue samples expressed synaptophysin and chromogranin and were also oestrogen and progesterone receptor positive; median Ki‐67 index was 50% (range 20–90%). All seven patients had demonstrated avidity on 18F‐FDG PET imaging, and the six who underwent 68Ga‐DOTATATE PET all had significant avidity. Treatment modalities and sequencing varied, but all patients received chemotherapy during their disease course. Six patients received three or more lines of treatment. Median overall survival was 31.8 months (range 3.7–108.6). Median progression‐free survival (PFS) with first‐line therapy for metastatic disease was 5.8 months (range 1.8–37.8). Conclusions: This series shows the use of multiple modalities in treating this disease, with different sequencing in different patients. Despite multiple modalities used in the first‐line setting, first‐line PFS remains short. Larger series and further molecular characterisation are required to aid clinicians in managing this condition and to guide optimal treatment sequencing to improve outcomes in this rare patient group. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
43. MasakhaPOS: Part-of-Speech Tagging for Typologically Diverse African languages
- Author
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Dione, Cheikh M. Bamba, primary, Adelani, David Ifeoluwa, additional, Nabende, Peter, additional, Alabi, Jesujoba, additional, Sindane, Thapelo, additional, Buzaaba, Happy, additional, Muhammad, Shamsuddeen Hassan, additional, Emezue, Chris Chinenye, additional, Ogayo, Perez, additional, Aremu, Anuoluwapo, additional, Gitau, Catherine, additional, Mbaye, Derguene, additional, Mukiibi, Jonathan, additional, Sibanda, Blessing, additional, Dossou, Bonaventure F. P., additional, Bukula, Andiswa, additional, Mabuya, Rooweither, additional, Tapo, Allahsera Auguste, additional, Munkoh-Buabeng, Edwin, additional, Memdjokam Koagne, Victoire, additional, Ouoba Kabore, Fatoumata, additional, Taylor, Amelia, additional, Kalipe, Godson, additional, Macucwa, Tebogo, additional, Marivate, Vukosi, additional, Gwadabe, Tajuddeen, additional, Elvis, Mboning Tchiaze, additional, Onyenwe, Ikechukwu, additional, Atindogbe, Gratien, additional, Adelani, Tolulope, additional, Akinade, Idris, additional, Samuel, Olanrewaju, additional, Nahimana, Marien, additional, Musabeyezu, Théogène, additional, Niyomutabazi, Emile, additional, Chimhenga, Ester, additional, Gotosa, Kudzai, additional, Mizha, Patrick, additional, Agbolo, Apelete, additional, Traore, Seydou, additional, Uchechukwu, Chinedu, additional, Yusuf, Aliyu, additional, Abdullahi, Muhammad, additional, and Klakow, Dietrich, additional
- Published
- 2023
- Full Text
- View/download PDF
44. Evaluating a Large-Scale Rollout of a Pharmacist-Led Information Technology Intervention (PINCER) in English General Practice
- Author
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Taylor, Amelia, primary, Avery, Anthony, additional, Roberts, Steve, additional, Ashcroft, Darren, additional, Rodgers, Sarah, additional, Elliott, Rachel, additional, and Allen, Thomas, additional
- Published
- 2023
- Full Text
- View/download PDF
45. The structure of symmetric n-player games when influence and independence collide
- Author
-
Molitor, Denali, Steel, Mike, and Taylor, Amelia
- Published
- 2015
- Full Text
- View/download PDF
46. Developing a statistically powerful measure for quartet tree inference using phylogenetic identities and Markov invariants
- Author
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Sumner, Jeremy G., Taylor, Amelia, Holland, Barbara R., and Jarvis, Peter D.
- Published
- 2017
- Full Text
- View/download PDF
47. Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study
- Author
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Rodgers, Sarah, primary, Taylor, Amelia C., additional, Roberts, Stephen A., additional, Allen, Thomas, additional, Ashcroft, Darren M., additional, Barrett, James, additional, Boyd, Matthew J., additional, Elliott, Rachel A., additional, Khunti, Kamlesh, additional, Sheikh, Aziz, additional, Laparidou, Despina, additional, Siriwardena, Aloysius Niroshan, additional, and Avery, Anthony J., additional
- Published
- 2022
- Full Text
- View/download PDF
48. Metastatic primary breast neuroendocrine neoplasms: a case series
- Author
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Batty, Kathleen, primary, Taylor, Amelia M., additional, Bernard, Elizabeth J., additional, Diakos, Connie I., additional, Clarke, Stephen J., additional, Guminski, Alexander, additional, Baron‐Hay, Sally, additional, Boyle, Frances, additional, Pavlakis, Nick, additional, and Chan, David L., additional
- Published
- 2022
- Full Text
- View/download PDF
49. BRAF inhibitor cessation prior to disease progression in metastatic melanoma: Long-term outcomes
- Author
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Lee, Joanna, Ahmed, Tasnia, Maurichi, Andrea, Di Guardo, Lorenzo, Stagno, Anna M., Warburton, Lydia, Taylor, Amelia. M., Livingstone, Elisabeth, Rehman, Saba, Khattak, Adnan, Kahler, Katharina C., Vanella, Vito, Atkinson, Victoria, Millward, Michael, Schadendorf, Dirk, Johnson, Douglas B., Ascierto, Paolo A., Hauschild, Axel, Lo, Serigne N., Long, Georgina V., Menzies, Alexander M., Carlino, Matteo S., and Di Guardo, Lorenza
- Subjects
Cancer Research ,Oncology ,Medizin - Abstract
BRAF mutant melanoma treated with BRAF ± MEK inhibitor (targeted therapy) has a high response rate; however, most patients progress (PD). Some patients have durable response, but it is unknown whether treatment can be discontinued in these patients. We describe the recurrence risk, progression patterns, response to subsequent treatment, and survival of patients with advanced melanoma who ceased targeted therapy prior to PD.Ninety-four patients who ceased targeted therapy without progression were identified retrospectively from 11 centres: 45 were male; 81 V600E; 88 stage IV. Fifty-nine were treated with BRAF + MEK inhibitor, and 35 were treated with BRAF inhibitor alone. Median treatment duration was 29.6 months (range 0.36-77.9). At cessation, 67 were in complete response, 21 in partial response, and 2 stable disease.After median follow-up from cessation of 42.9 months (range 0.0-88.7), 36 (38%) progressed; median time to progression was 4.7 months (range 0.7-56.9); 30 (83%) were asymptomatic and 7 (19%) had new brain metastases. Progression rates did not differ by best response: 34% for complete response and 43% for partial response (P = 0.65). Treatment duration was strongly associated with risk of progression: Median treatment duration was 18.3 (range 0.85-65.7) months for those who progressed and 34.6 (range 0.36-77.9) months for those who did not (P = 0.0004). Twenty-two received further targeted therapy with 15 (68%) responses.Risk of progression after cessation of targeted therapy is strongly associated with treatment duration. Response to retreatment with targeted therapy is high.
- Published
- 2022
50. A Systematic Review of Systematic Reviews Exploring the Factors Related to Child and Adolescent Self-Harm
- Author
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Varley, Danielle, primary, Fenton, Clare, additional, Gargan, Georgina, additional, Taylor, Olivia, additional, Taylor, Amelia, additional, Kirby, Natalie, additional, Morton, Michael, additional, Barrow, Jamie, additional, Hatton, Christopher, additional, and Wright, Barry, additional
- Published
- 2022
- Full Text
- View/download PDF
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