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Falling from windows as a mechanism of traumatic injury has been a priority for public health interventions since the 1970s, yet window falls remain a cause of injury and death in children. The complexity of the issue requires a multilayered approach well represented by the socioecological model (SEM). This analysis of local window fall events, prevention efforts, and existing legislation promotes an opportunity to ensure child safety and family well-being in California and other communities by providing recommendations for cost-effective and trauma-informed policy to prevent unintentional pediatric window falls., Falls are the leading cause of nonfatal injury in U.S. children (Centers for Disease Control and Prevention [CDC], 2023). More than 1.3 million children younger than 18 visit an emergency [...]

Ruminococcus gnavus is a human gut symbiont wherein the ability to degrade mucins is mediated by an intramolecular trans-sialidase (RgNanH). RgNanH comprises a GH33 catalytic domain and a sialic acid-binding carbohydrate-binding module (CBM40). Here we used glycan arrays, STD NMR, X-ray crystallography, mutagenesis and binding assays to determine the structure and function of RgNanH_CBM40 (RgCBM40). RgCBM40 displays the canonical CBM40 β-sandwich fold and broad specificity towards sialoglycans with millimolar binding affinity towards α2,3- or α2,6-sialyllactose. RgCBM40 binds to mucus produced by goblet cells and to purified mucins, providing direct evidence for a CBM40 as a novel bacterial mucus adhesin. Bioinformatics data show that RgCBM40 canonical type domains are widespread among Firmicutes. Furthermore, binding of R. gnavus ATCC 29149 to intestinal mucus is sialic acid mediated. Together, this study reveals novel features of CBMs which may contribute to the biogeography of symbiotic bacteria in the gut.

Renaissance clothes were piecemeal assemblages of parts. This pervasive practice is connected to early English theater, which emphasized variety rather than the (neo)classical focus on unity of time, place, action, genre, audience, and affect. Like aging costumes, aging plays could be updated by changing their parts without needing to create or buy something entirely new. Like early modern clothes and costumes, and like the earliest portraits of Shakespeare, the Shakespeare First Folio of 1623 is a heterogeneous miscellany. But for marketing purposes the Folio constructs a series of bibliographical and rhetorical uniformity-effects. The Folio celebrates 'the great Variety of Readers' but denigrates the great variety of play-texts. Its claims to unity of authorship and condemnation of alternative printings underlie the myth of a unified one-parent canon consisting of one-version and one-date works., which misrepresents early modern composite play-production and its most successful patchwork playwright. To illustrate the complexity of the relationship between early performances and posthumous print, the essay examines in detail the Folio text of The Life of Henry the Fift, re-examining certain Folio-only passages in light of the known performance of the play by the King's Men at Whitehall for a court audience on 7 January 1605. [ABSTRACT FROM AUTHOR]

Being a continuous learner often is viewed as a key attribute of successful accounting professionals. This paper describes a project that engages master level financial accounting students directly in the standard-setting process by having students research, write and submit a class comment letter on a current Exposure Draft to the Financial Accounting Standards Board (FASB). This project integrates multiple competencies through experiential learning. The project is designed to provide students with first-hand experience engaging in the standard setting process, introduce students to some of the challenges with staying abreast of current developments, and help students develop tools and skills they can use throughout their careers to learn about emerging accounting issues and critically analyze alternative solutions. JEL Classifications: M41. [ABSTRACT FROM AUTHOR]