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1. Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study

Author

Scichilone, N, Antonelli Incalzi, R, Blasi, F, Schino, P, Cuttitta, G, Zullo, A, Ori, A, Canonica, G, Foschino, M, Prediletto, R, Tranfa, C, Zappa, M, Patriciello, P, Labate, L, Mariotta, S, Nava, S, Vatrella, A, Mastroberardino, M, Sarzani, R, Iuliano, A, Maggi, L, Zedda, A, Pesci, A, Sera, G, Nicolini, A, Salvatore Walter, D, Forte, S, Mario, D, Rivolta, F, Ferliga, M, Raco, A, Luigi, D, Cabibbo, G, Maselli, R, Gulotta, C, Nardini, S, Guffanti, E, Castellani, W, Triolo, L, Passalacqua, G, Beghe, B, Salvatore, L, Faccini, E, Atzeni, E, Tazza, R, Giamesio, P, Scichilone N., Antonelli Incalzi R., Blasi F., Schino P., Cuttitta G., Zullo A., Ori A., Canonica G., Foschino M. P., Prediletto R., Tranfa C. M. E., Zappa M. C., Patriciello P., Labate L., Mariotta S., Nava S., Vatrella A., Mastroberardino M., Sarzani R., Iuliano A., Maggi L., Zedda A., Pesci A., Sera G., Nicolini A., Salvatore Walter D. D., Forte S., Mario D. D., Rivolta F., Ferliga M., Raco A. F., Luigi D. R., Cabibbo G., Maselli R., Gulotta C., Nardini S., Guffanti E. E., Castellani W., Triolo L., Passalacqua G., Beghe B., Salvatore L. C., Faccini E., Atzeni E., Tazza R., Giamesio P., Scichilone, N, Antonelli Incalzi, R, Blasi, F, Schino, P, Cuttitta, G, Zullo, A, Ori, A, Canonica, G, Foschino, M, Prediletto, R, Tranfa, C, Zappa, M, Patriciello, P, Labate, L, Mariotta, S, Nava, S, Vatrella, A, Mastroberardino, M, Sarzani, R, Iuliano, A, Maggi, L, Zedda, A, Pesci, A, Sera, G, Nicolini, A, Salvatore Walter, D, Forte, S, Mario, D, Rivolta, F, Ferliga, M, Raco, A, Luigi, D, Cabibbo, G, Maselli, R, Gulotta, C, Nardini, S, Guffanti, E, Castellani, W, Triolo, L, Passalacqua, G, Beghe, B, Salvatore, L, Faccini, E, Atzeni, E, Tazza, R, Giamesio, P, Scichilone N., Antonelli Incalzi R., Blasi F., Schino P., Cuttitta G., Zullo A., Ori A., Canonica G., Foschino M. P., Prediletto R., Tranfa C. M. E., Zappa M. C., Patriciello P., Labate L., Mariotta S., Nava S., Vatrella A., Mastroberardino M., Sarzani R., Iuliano A., Maggi L., Zedda A., Pesci A., Sera G., Nicolini A., Salvatore Walter D. D., Forte S., Mario D. D., Rivolta F., Ferliga M., Raco A. F., Luigi D. R., Cabibbo G., Maselli R., Gulotta C., Nardini S., Guffanti E. E., Castellani W., Triolo L., Passalacqua G., Beghe B., Salvatore L. C., Faccini E., Atzeni E., Tazza R., and Giamesio P.

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype. Methods: The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline early-morning, day-time and nocturnal symptoms (gathered via the Night-time, Morning and Day-time Symptoms of COPD questionnaire), HR-QoL (via the St. George's Respiratory Questionnaire), anxiety and depression levels (via the Hospital Anxiety and Depression Scale), quality of sleep (via COPD and Asthma Sleep Impact Scale), physical activity (via the International Physical Activity Questionnaire) as well as lung function were recorded. Results: 606 COPD subjects (age 71.4 ± 8.2 years, male 75.1%) were studied. 57.9, 35.5 5.3 and 1.3% of the sample belonged to the CB, EM, MCA and EM + CB phenotypes respectively. The vast majority of subjects reported early-morning and day-time symptoms (79.5 and 79.2% in the CB and 75.8 and 77.7% in the EM groups); the proportion suffering from night-time symptoms was higher in the CB than in the EM group (53.6% vs. 39.5%, p = 0.0016). In both CB and EM, indiscriminately, the presence of symptoms during the 24-h day was associated with poorer HR-QoL, worse quality of sleep and higher levels of anxiety/depression. Conclusions: The findings highlight the primary classificatory role of nocturnal symptoms in COPD. Trial registration: Trial registration number: NCT03105999, date of registration: 10th April 2017.

Published
2019

2. Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study

Author

Scichilone, Nicola, Antonelli Incalzi, Raffaele, Blasi, Francesco, Schino, Pietro, Cuttitta, Giuseppina, Zullo, Alessandro, Ori, Alessandra, Canonica, Giorgio Walter, Schino P, Cuttitta G, Foschino MP, Prediletto R, Tranfa C, Zappa MC, Patriciello P, Labate L, Mariotta S, Nava S, Vatrella A, Mastroberardino M, Sarzani R, Iuliano A, Maggi L, Zedda A, Pesci A, Sera G, Nicolini A, Salvatore Walter DD, Forte S, Mario DD, Rivolta F, Ferliga M, Raco AF, Luigi DR, Cabibbo G, Maselli R, Gulotta C, Nardini S, Guffanti EE, Castellani W, Triolo L, Passalacqua G, Beghè B, Salvatore LC, Faccini E, Atzeni E, Tazza R, Giamesio P., Scichilone N., Antonelli Incalzi R., Blasi F., Schino P., Cuttitta G., Zullo A., Ori A., Canonica G., Foschino M.P., Prediletto R., Tranfa C.M.E., Zappa M.C., Patriciello P., Labate L., Mariotta S., Nava S., Vatrella A., Mastroberardino M., Sarzani R., Iuliano A., Maggi L., Zedda A., Pesci A., Sera G., Nicolini A., Salvatore Walter D.D., Forte S., Mario D.D., Rivolta F., Ferliga M., Raco A.F., Luigi D.R., Cabibbo G., Maselli R., Gulotta C., Nardini S., Guffanti E.E., Castellani W., Triolo L., Passalacqua G., Beghe B., Salvatore L.C., Faccini E., Atzeni E., Tazza R., Giamesio P., Scichilone, N, Antonelli Incalzi, R, Blasi, F, Schino, P, Cuttitta, G, Zullo, A, Ori, A, Canonica, G, Foschino, M, Prediletto, R, Tranfa, C, Zappa, M, Patriciello, P, Labate, L, Mariotta, S, Nava, S, Vatrella, A, Mastroberardino, M, Sarzani, R, Iuliano, A, Maggi, L, Zedda, A, Pesci, A, Sera, G, Nicolini, A, Salvatore Walter, D, Forte, S, Mario, D, Rivolta, F, Ferliga, M, Raco, A, Luigi, D, Cabibbo, G, Maselli, R, Gulotta, C, Nardini, S, Guffanti, E, Castellani, W, Triolo, L, Passalacqua, G, Beghe, B, Salvatore, L, Faccini, E, Atzeni, E, Tazza, R, Giamesio, P, Scichilone, Nicola, Antonelli Incalzi, Raffaele, Blasi, Francesco, Schino, Pietro, Cuttitta, Giuseppina, Zullo, Alessandro, Ori, Alessandra, Canonica, Giorgio, Walter, Foschino, Mp, Zappa, Mc, Salvatore Walter, Dd, Mario, Dd, Raco, Af, Luigi, Dr, Guffanti, Ee, Beghè, B, Salvatore, Lc, and Giamesio, P.

Subjects
Male, Chronic bronchitis, Time Factors, Health Status, Anxiety, Hospital Anxiety and Depression Scale, Severity of Illness Index, Health Statu, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Surveys and Questionnaires, Forced Expiratory Volume, Clinical phenotype, Medicine, Surveys and Questionnaire, Respiratory function, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Lung, Depression (differential diagnoses), COPD, Depression, Middle Aged, Circadian Rhythm, Phenotype, Italy, Female, medicine.symptom, 24-hour symptoms, Clinical phenotype, Real-world, Respiratory function, Research Article, Human, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Chronic Obstructive, Time Factor, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Pulmonary Disease, 03 medical and health sciences, Internal medicine, Humans, Asthma, 24-hour symptoms, Real-world, Aged, Sleep, Quality of Life, lcsh:RC705-779, business.industry, Correction, lcsh:Diseases of the respiratory system, medicine.disease, 24-hour symptom, Prospective Studie, 030228 respiratory system, business
Abstract

Background Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype. Methods The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline early-morning, day-time and nocturnal symptoms (gathered via the Night-time, Morning and Day-time Symptoms of COPD questionnaire), HR-QoL (via the St. George’s Respiratory Questionnaire), anxiety and depression levels (via the Hospital Anxiety and Depression Scale), quality of sleep (via COPD and Asthma Sleep Impact Scale), physical activity (via the International Physical Activity Questionnaire) as well as lung function were recorded. Results 606 COPD subjects (age 71.4 ± 8.2 years, male 75.1%) were studied. 57.9, 35.5 5.3 and 1.3% of the sample belonged to the CB, EM, MCA and EM + CB phenotypes respectively. The vast majority of subjects reported early-morning and day-time symptoms (79.5 and 79.2% in the CB and 75.8 and 77.7% in the EM groups); the proportion suffering from night-time symptoms was higher in the CB than in the EM group (53.6% vs. 39.5%, p = 0.0016). In both CB and EM, indiscriminately, the presence of symptoms during the 24-h day was associated with poorer HR-QoL, worse quality of sleep and higher levels of anxiety/depression. Conclusions The findings highlight the primary classificatory role of nocturnal symptoms in COPD. Trial registration Trial registration number: NCT03105999, date of registration: 10th April 2017.

Published
2019

10. Evaluation of tuberculosis treatment results in Italy, report 1998

Author

Centis, R., Ianni, A., Migliori, G. B., Casali, L., Agati, G., Aiolfi, S., Altieri, A., Ambrosetti, M., Angarano, G., Arossa, W., Bagnasco, G., Bazzerla, G., Berra, A., Besozzi, G., Bottrighi, P., Bugiani, M., Calabro, S., Castiglioni, G., Cavallero, M., Cicchitto, G., luigi codecasa, Colorizio, V., Confalonieri, M., D Ambrosio, L., D Ambrosio, V., Dellatommasa, S., Di Pisa, G., Ermeti, M., Faccini, E., Falcone, F., Farinelli, G., Fatigante, R., Farris, B., Fatur Volante, T., Felisatti, G., Ferranti, P., Fiorentini, F., Foschi, C., Garzone, A., Giorgio, V., Gozzellino, F., Jacopino, L., Lauriello, G., Le Donne, R., Longi, R., Macor, G., Mancini, D., Marchesani, M. F., Marcias, S., Mariano, V., Mennea, G., Monaco, A., Montesano, G., Moretti, G., Napolitano, G., Nardini, S., Nutini, S., Orani, G., Orsi, A., Parpanesi, M., Pasi, A., Penza, O., Perboni, A., Petrozzi, L., Pretto, P., Rossi, S., Sabato, E., Saini, L., Schiavi, L., Tazza, R., Trucco, G., Vertuccio, C., Viviani, U., Volante, M., Vinciguerra, P., Viola, S., Zaccara, F., Barelle, L., Bertoli, G., Bisetti, A., Bistoni, F., Buono, L., Carbonara, S., Carosi, G. P., Cascina, A., Cassone, A., Costa, D., Crepaldi, P., Santis, A., Diamare, F., Fabbro, L., Fadda, G., Farris, A. G., Fattorini, L., Ferrara, G., Gamba, S., Iona, E., and Losi, M.

11. Satisfaction with chronic obstructive pulmonary disease treatment: results from a multicenter, observational study

Author

Marco Contoli, Paola Rogliani, Fabiano Di Marco, Fulvio Braido, Angelo G. Corsico, Christian A. Amici, Roberto Piro, Riccardo Sarzani, Patrizia Lessi, Carla Scognamillo, Nicola Scichilone, Pierachille Santus, Angelo Guido Corsico, Rita Raccanelli, Dejan Radovanovic, Erica Gini, Vincenzo Patella, Giovanni Florio, Silvia Garuti, Giacomo Forini, Alida Benfante, Giuseppe Fiorentino, Antonella Marotta, Fausta Alfano, Francesco Cavalli, Patrizia Ruggiero, Mauro Carone, Maria Aliani, Antonio Iannaccone, Alessandro Izzo, Biago Polla, Francesco Spannella, Claudio Micheletto, Rigoletta Vincenti, Laura Maugeri, Carlo Gulotta, Roberto Tazza, Luigi Di Re, Paolo Mimotti, Roberto Carbone, Rodolfo Riva, Giovanni Fiori, Stefano Viaggi, Alessandra Ori, Lucia Simoni, Christian Amici, Fabio Ferri, Barbara Roncari, Saide Sala, Francesca Trevisan, Nicole Lanci, Contoli M., Rogliani P., Di Marco F., Braido F., Corsico A.G., Amici C.A., Piro R., Sarzani R., Lessi P., Scognamillo C., Scichilone N., Santus P., Raccanelli R., Radovanovic D., Gini E., Patella V., Florio G., Garuti S., Forini G., Benfante A., Fiorentino G., Marotta A., Alfano F., Cavalli F., Ruggiero P., Carone M., Aliani M., Iannaccone A., Izzo A., Polla B., Spannella F., Micheletto C., Vincenti R., Maugeri L., Gulotta C., Tazza R., Di Re L., Mimotti P., Carbone R., Riva R., Fiori G., Viaggi S., Ori A., Simoni L., Amici C., Ferri F., Roncari B., Sala S., Trevisan F., and Lanci N.

Subjects
Pulmonary and Respiratory Medicine, Male, Chronic Obstructive, medicine.medical_specialty, COPD, adherence, treatment satisfaction, Pulmonary disease, Socio-culturale, Treatment results, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Outcome (game theory), Medication Adherence, Pulmonary Disease, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Surveys and Questionnaires, Administration, Inhalation, Settore MED/10, Medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Intensive care medicine, Original Research, Aged, lcsh:RC705-779, adherence, COPD, treatment satisfaction, business.industry, lcsh:Diseases of the respiratory system, Middle Aged, Dyspnea, Inhalation, 030228 respiratory system, Italy, Patient Satisfaction, Administration, Observational study, Female, business, Follow-Up Studies
Abstract

Background: Understanding the level of patients’ satisfaction with treatment and its determinants have the potential to impact therapeutic management and clinical outcome in chronic conditions such as chronic obstructive pulmonary disease (COPD). Methods: A national, multicenter, longitudinal, observational study of COPD from 20 Italian pulmonary centers to explore patients’ satisfaction to treatment [assessed by the Treatment Satisfaction Questionnaire, 9 items (TSQM-9)] and association with clinical parameters [including dyspnea score, COPD Assessment Test (CAT) score, exacerbation rate], adherence to treatment [Morisky Medication-Taking Adherence Scale (MMAS-4)], illness perception [evaluated by Brief Illness Perception Questionnaire (B-IPQ)] in a 1-year follow up. Results: A total of 401 COPD patients were enrolled [69.4% group B Global Initiative for COPD (GOLD), considering 366 patients with available GOLD 2017 classification at enrollment]. At enrollment, satisfaction with treatment was moderate, being TSQM-9 mean scores for effectiveness 64.2 [95% confidence interval (CI) 62.5–65.9], for convenience 75.8 (95% CI 74.2–77.3), and for global satisfaction 65.7 (95% CI 64.0–67.4). Global satisfaction was negatively associated with disease perception (β = −0.4709, p Conclusions: The results of this real-life study showed that the patients’ satisfaction with treatments is only moderate in COPD. A high grade of patients’ satisfaction is associated mainly with a low perception of the disease, high adherence to treatment and lower level of dyspnea. Trial Registration: Clinicaltrials.gov identifier: NCT02689492 The reviews of this paper are available via the supplemental material section.

Published
2019

12. Efficacy and safety of a new immunostimulating bacterial lysate in the prophylaxis of acute lower respiratory tract infections. A randomised, open, controlled clinical trial.

Author

Rossi S and Tazza R

Subjects
Adjuvants, Immunologic administration & dosage, Adjuvants, Immunologic adverse effects, Administration, Oral, Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Bacterial Vaccines administration & dosage, Bacterial Vaccines adverse effects, Cough etiology, Cough pathology, Female, Humans, Male, Middle Aged, Pain etiology, Respiratory Tract Infections complications, Sputum, Adjuvants, Immunologic therapeutic use, Bacteria immunology, Bacterial Vaccines therapeutic use, Respiratory Tract Infections prevention & control
Published
2004
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13. [Picotamide: use in chronic obliterative arteriopathies of the lower limbs].

Author

Tazza G, Tazza R, Valentini M, Leoni G, Avenia N, and Ragusa M

Subjects
Aged, Arterial Occlusive Diseases diagnosis, Female, Humans, Male, Middle Aged, Phthalic Acids administration & dosage, Time Factors, Arterial Occlusive Diseases drug therapy, Leg blood supply, Phthalic Acids therapeutic use
Abstract

In the present study the authors evaluated treatment efficiency and patient compliance of medium-term therapy with Picotamide, given in doses of 900 mg/die for the first 15 days, and 600 mg/die up to the completion of a three-month period, to 50 patients affected by vaso-occlusive arterial disease of the lower limbs. At follow-up visits the following controls have been carried out: CW Doppler sonography of the lower limbs, Maximum Walking Distance (M.W.D.), Red blood cell count, White blood cell count, Platelet count, Haemoglobin and Fibrinogen levels. At the end of the three-month therapy period the Ankle-Arm parameters remained unchanged.

Published
1991

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