1. Bioactive Arylnaphthalide Lignans from Justicia depauperata .
- Author
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Tchegnitegni Toussie B, Nguengang RT, Mawabo IK, Teponno RB, Kezetas Bankeu JJ, Chouna JR, Nkenfou CN, Tapondjou LA, Sewald N, and Lenta BN
- Subjects
- Plant Extracts chemistry, Molecular Structure, Lignans pharmacology, Lignans chemistry, Justicia chemistry, Acanthaceae chemistry, Drugs, Chinese Herbal chemistry
- Abstract
Eleven previously undescribed arylnaphthalide lignans ( 1 - 11 ) together with seven known compounds were isolated from the whole plant of Justicia depauperata . The structures of 1 - 11 were elucidated by spectroscopic analysis and mass spectrometry. Compounds 6 (IC
50 = 4.1 μM) and 9 (IC50 = 9.5 μM) displayed cytotoxic activity against the KB-3-1 cervical carcinoma cell line. This report provides an insight into the conformational equilibria occurring in the arylnaphthalide lignan constituents of this plant.- Published
- 2022
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