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147 results on '"Teague, Ryan M."'

9. Data from Fructose Promotes Cytoprotection in Melanoma Tumors and Resistance to Immunotherapy

Author

Kuehm, Lindsey M., primary, Khojandi, Niloufar, primary, Piening, Alexander, primary, Klevorn, Lauryn E., primary, Geraud, Simone C., primary, McLaughlin, Nicole R., primary, Griffett, Kristine, primary, Burris, Thomas P., primary, Pyles, Kelly D., primary, Nelson, Afton M., primary, Preuss, Mary L., primary, Bockerstett, Kevin A., primary, Donlin, Maureen J., primary, McCommis, Kyle S., primary, DiPaolo, Richard J., primary, and Teague, Ryan M., primary

Published
2023
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10. Data from Oxidized Lipoproteins Promote Resistance to Cancer Immunotherapy Independent of Patient Obesity

Author

Khojandi, Niloufar, primary, Kuehm, Lindsey M., primary, Piening, Alexander, primary, Donlin, Maureen J., primary, Hsueh, Eddy C., primary, Schwartz, Theresa L., primary, Farrell, Kaitlin, primary, Richart, John M., primary, Geerling, Elizabeth, primary, Pinto, Amelia K., primary, George, Sarah L., primary, Albert, Carolyn J., primary, Ford, David A., primary, Chen, Xiufen, primary, Kline, Justin, primary, and Teague, Ryan M., primary

Published
2023
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11. Supplemental Figures S1-S9 from Fructose Promotes Cytoprotection in Melanoma Tumors and Resistance to Immunotherapy

Author

Kuehm, Lindsey M., primary, Khojandi, Niloufar, primary, Piening, Alexander, primary, Klevorn, Lauryn E., primary, Geraud, Simone C., primary, McLaughlin, Nicole R., primary, Griffett, Kristine, primary, Burris, Thomas P., primary, Pyles, Kelly D., primary, Nelson, Afton M., primary, Preuss, Mary L., primary, Bockerstett, Kevin A., primary, Donlin, Maureen J., primary, McCommis, Kyle S., primary, DiPaolo, Richard J., primary, and Teague, Ryan M., primary

Published
2023
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12. Supplemental Figures from Oxidized Lipoproteins Promote Resistance to Cancer Immunotherapy Independent of Patient Obesity

Author

Khojandi, Niloufar, primary, Kuehm, Lindsey M., primary, Piening, Alexander, primary, Donlin, Maureen J., primary, Hsueh, Eddy C., primary, Schwartz, Theresa L., primary, Farrell, Kaitlin, primary, Richart, John M., primary, Geerling, Elizabeth, primary, Pinto, Amelia K., primary, George, Sarah L., primary, Albert, Carolyn J., primary, Ford, David A., primary, Chen, Xiufen, primary, Kline, Justin, primary, and Teague, Ryan M., primary

Published
2023
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24. Single-cell analysis of peripheral CD8+ T cell responses in patients receiving checkpoint blockade immunotherapy for cancer.

Author

Khojandi, Niloufar, Connelly, Louis, Piening, Alexander, Hoft, Stella G., Pherson, Michelle, Donlin, Maureen J., DiPaolo, Richard J., and Teague, Ryan M.

Subjects
T cells, CYTOTOXIC T cells, T cell receptors, IMMUNOTHERAPY, ANTI-NMDA receptor encephalitis, IMMUNE response
Abstract

Checkpoint blockade immunotherapy has become a first-line treatment option for cancer patients, with success in increasingly diverse cancer types. Still, many patients do not experience durable responses and the reasons for clinical success versus failure remain largely undefined. Investigation of immune responses within the tumor microenvironment can be highly informative but access to tumor tissue is not always available, highlighting the need to identify biomarkers in the blood that correlate with clinical success. Here, we used single-cell RNA sequencing coupled with T cell receptor sequencing to define CD8+ T cell responses in peripheral blood of two patients with melanoma before and after immunotherapy with either anti-PD-1 (nivolumab) alone or the combination of anti-PD-1 and CTLA-4 (ipilimumab). Both treatment regimens increased transcripts associated with cytolytic effector function and decreased transcripts associated with naive T cells. These responses were further evaluated at the protein level and extended to a total of 53 patients with various cancer types. Unexpectedly, the induction of CD8+ T cell responses associated with cytolytic function was variable and did not predict therapeutic success in this larger patient cohort. Rather, a decrease in the frequency of T cells with a naive-like phenotype was consistently observed after immunotherapy and correlated with prolonged patient survival. In contrast, a more detailed clonotypic analysis of emerging and expanding CD8+ T cells in the blood revealed that a majority of individual T cell clones responding to immunotherapy acquired a transcriptional profile consistent with cytolytic effector function. These results suggest that responses to checkpoint blockade immunotherapy are evident and traceable in patients' blood, with outcomes predicted by the simultaneous loss of naive-like CD8+ T cells and the expansion of mostly rare and diverse cytotoxic CD8+ T cell clones. [ABSTRACT FROM AUTHOR]

Published
2023
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25. CD40 ligation reverses T cell tolerance in acute myeloid leukemia

Author

Zhang, Long, Chen, Xiufen, Liu, Xiao, Kline, Douglas E., Teague, Ryan M., Gajewski, Thomas F., and Kline, Justin

Subjects
Immunization -- Methods -- Research, CD4 lymphocytes -- Physiological aspects, Health care industry
Abstract

Spontaneous antigen-specific T cell responses can be generated in hosts harboring a variety of solid malignancies, but are subverted by immune evasion mechanisms active within the tumor microenvironment. In contrast [...]

Published
2013
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27. Fructose Promotes Cytoprotection in Melanoma Tumors and Resistance to Immunotherapy

Author

Kuehm, Lindsey M., primary, Khojandi, Niloufar, additional, Piening, Alexander, additional, Klevorn, Lauryn E., additional, Geraud, Simone C., additional, McLaughlin, Nicole R., additional, Griffett, Kristine, additional, Burris, Thomas P., additional, Pyles, Kelly D., additional, Nelson, Afton M., additional, Preuss, Mary L., additional, Bockerstett, Kevin A., additional, Donlin, Maureen J., additional, McCommis, Kyle S., additional, DiPaolo, Richard J., additional, and Teague, Ryan M., additional

Published
2021
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28. Oxidized Lipoproteins Promote Resistance to Cancer Immunotherapy Independent of Patient Obesity

Author

Khojandi, Niloufar, primary, Kuehm, Lindsey M., additional, Piening, Alexander, additional, Donlin, Maureen J., additional, Hsueh, Eddy C., additional, Schwartz, Theresa L., additional, Farrell, Kaitlin, additional, Richart, John M., additional, Geerling, Elizabeth, additional, Pinto, Amelia K., additional, George, Sarah L., additional, Albert, Carolyn J., additional, Ford, David A., additional, Chen, Xiufen, additional, Kline, Justin, additional, and Teague, Ryan M., additional

Published
2021
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29. Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors

Author

Teague, Ryan M, Sather, Blythe D, Sacks, Jilian A, Huang, Maria Z, Dossett, Michelle L, Morimoto, Junko, Tan, Xiaoxio, Sutton, Susan E, Cooke, Michael P, Ohlen, Claes, and Greenberg, Philip D

Abstract

Author(s): Ryan M Teague [1, 2]; Blythe D Sather [1]; Jilian A Sacks [1]; Maria Z Huang [1]; Michelle L Dossett [1, 2]; Junko Morimoto [1, 2]; Xiaoxio Tan [1, [...]

Published
2006
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45. Neuropilin-1 Expression Is Induced on Tolerant Self-Reactive CD8+ T Cells but Is Dispensable for the Tolerant Phenotype.

Author

Jackson, Stephanie R., Berrien-Elliott, Melissa, Yuan, Jinyun, Hsueh, Eddy C., and Teague, Ryan M.

Subjects
NEUROPILINS, T cells, IMMUNITY, PHENOTYPES, IMMUNE system
Abstract

Establishing peripheral CD8+ T cell tolerance is vital to avoid immune mediated destruction of healthy self-tissues. However, it also poses a major impediment to tumor immunity since tumors are derived from self-tissue and often induce T cell tolerance and dysfunction. Thus, understanding the mechanisms that regulate T cell tolerance versus immunity has important implications for human health. Signals received from the tissue environment largely dictate whether responding T cells become activated or tolerant. For example, induced expression and subsequent ligation of negative regulatory receptors on the surface of self-reactive CD8+ T cells are integral in the induction of tolerance. We utilized a murine model of T cell tolerance to more completely define the molecules involved in this process. We discovered that, in addition to other known regulatory receptors, tolerant self-reactive CD8+ T cells distinctly expressed the surface receptor neuropilin-1 (Nrp1). Nrp1 was highly induced in response to self-antigen, but only modestly when the same antigen was encountered under immune conditions, suggesting a possible mechanistic link to T cell tolerance. We also observed a similar Nrp1 expression profile on human tumor infiltrating CD4+ and CD8+ T cells. Despite high expression on tolerant CD8+ T cells, our studies revealed that Nrp1 had no detectable role in the tolerant phenotype. Specifically, Nrp1-deficient T cells displayed the same functional defects as wild-type self-reactive T cells, lacking in vivo cytolytic potential, IFNγ production, and antitumor responses. While reporting mostly negative data, our findings have therapeutic implications, as Nrp1 is now being targeted for human cancer therapy in clinical trials, but the precise molecular pathways and immune cells being engaged during treatment remain incompletely defined. [ABSTRACT FROM AUTHOR]

Published
2014
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