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2. Patient-Reported Continued Benefits in Patients Treated with Pexidartinib for Tenosynovial Giant Cell Tumor Based on a Real-World Study in the United States

Author

Margaret Wooddell PhD, MBA, Dong Dai PhD, Feng Lin PhD, Irene Pan MS, Klaus Freivogel PhD, Xin Ye PhD, Kristen Tecson PhD, and William D. Tap MD

Subjects
Orthopedic surgery, RD701-811
Abstract

Category: Other Introduction/Purpose: Tenosynovial giant cell tumors (TGCT) are neoplastic, inflammatory lesions that arise within the synovium and can be locally aggressive. Patients with TGCT frequently experience pain and joint swelling, stiffness, reduced range of motion, and instability in affected joints. Surgical resection is standard treatment for TGCT; however, the diffuse subtype is associated with poor surgical outcomes and high rates of disease recurrence. Pexidartinib (Turalio ® ), a CSF-1R antagonist, is the first and only systemic therapy approved by the FDA for treatment of adult patients with symptomatic TGCT associated with severe morbidity or functional limitations and not amenable to improvement with surgery. The objective of this study was to assess symptom change over time among adult patients who were treated with pexidartinib for TGCT in a real-world setting. Methods: This was a longitudinal observational study of patients receiving pexidartinib for TGCT treatment in the real-world setting. The study collected Patient Reported Outcomes (PRO) from patient surveys prospectively and clinical data from medical charts retrospectively. The surveys were administered to adult patients enrolled in the post-market Turalio ® Risk Evaluation and Mitigation Strategy (REMS) program: the first wave was sent in 2021 (“Baseline”) and the final was sent in 2022 (“Follow-up”). Patients were required to be receiving pexidartinib before the Baseline Survey and to be on pexidartinib when they accessed the Follow-up Survey. The surveys consisted of validated instruments to measure PROs. The EQ-5D-5L was administered in the Follow-up Survey to understand patients’ general health state. The scores and paired changes from baseline were summarized by descriptive statistics and a random slope regression model was developed to adjust for the time since first pexidartinib dose. Results: Forty-five patients actively taking pexidartinib to treat TGCT were invited to participate in both waves of the survey; 31 (68.9%) participated in both surveys. Mean (SD) time between baseline and follow-up was 1.02 (0.17) years, mean (SD) age at follow-up was 41.9 (13.70) years, and 67.7% were female. The most common tumor sites were at the knee (67.7%), ankle (16.1%), foot (9.7%), and hip (9.7%) (non-mutually exclusive). Changes in PROs are shown in Table 1. During follow-up, at least 71% of respondents indicated slight or no problems in each of the five EQ-5D-5L domains. Since the start of the study, the majority (85.7%) of respondents experienced improved overall symptoms. Conclusion: In this study, most TGCT patients reported symptom improvement in physical function, stiffness and pain during pexidartinib treatment. After an additional year of follow-up, the PROs of physical function, worst stiffness, worst pain, and treatment satisfaction were sustained. The findings suggest longer-term benefits for patients continuing treatment with pexidartinib. Outcomes for patients who discontinued pexidartinib should be evaluated in future studies.

Published
2024
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5. Tracking Blood Pressure Control Performance and Process Metrics in 25 US Health Systems: The PCORnet Blood Pressure Control Laboratory

Author

Cooper-DeHoff, Rhonda M, Fontil, Valy, Carton, Thomas, Chamberlain, Alanna M, Todd, Jonathan, O'Brien, Emily C, Shaw, Kathryn M, Smith, Myra, Choi, Sujung, Nilles, Ester K, Ford, Daniel, Tecson, Kristen M, Dennar, Princess E, Ahmad, Faraz, Wu, Shenghui, McClay, James C, Azar, Kristen, Singh, Rajbir, Faulkner Modrow, Madelaine, Shay, Christina M, Rakotz, Michael, Wozniak, Gregory, and Pletcher, Mark J

Subjects
Patient Safety, Clinical Research, Hypertension, Cardiovascular, Good Health and Well Being, Adult, Antihypertensive Agents, Benchmarking, Blood Pressure, Cross-Sectional Studies, Female, Humans, Laboratories, Male, health equity, high blood pressure, hypertension, quality and outcomes, race and ethnicity, Cardiorespiratory Medicine and Haematology
Abstract

Background The National Patient-Centered Clinical Research Network Blood Pressure Control Laboratory Surveillance System was established to identify opportunities for blood pressure (BP) control improvement and to provide a mechanism for tracking improvement longitudinally. Methods and Results We conducted a serial cross-sectional study with queries against standardized electronic health record data in the National Patient-Centered Clinical Research Network (PCORnet) common data model returned by 25 participating US health systems. Queries produced BP control metrics for adults with well-documented hypertension and a recent encounter at the health system for a series of 1-year measurement periods for each quarter of available data from January 2017 to March 2020. Aggregate weighted results are presented overall and by race and ethnicity. The most recent measurement period includes data from 1 737 995 patients, and 11 956 509 patient-years were included in the trend analysis. Overall, 15% were Black, 52% women, and 28% had diabetes. BP control (

Published
2021

8. Comparison of Efficacy of Combined Phacoemulsification and iStent Inject versus Combined Phacoemulsification and Hydrus Microstent

Author

Chee WK, Yip VCH, Tecson IO, Chua CH, Ang BCH, Kee AR, Hu JY, Kan TCJ, and Yip LWL

Subjects
glaucoma, phacoemulsification, cataract extraction, istent inject, hydrus microstent, Ophthalmology, RE1-994
Abstract

Wai Kitt Chee,1 Vivien Cherng Hui Yip,1 Ivan O’Neill Tecson,1 Chun Hau Chua,1 Bryan Chin Hou Ang,1 Ae Ra Kee,1 Jeremy Youwei Hu,1 Tsia-Chuen John Kan,1 Leonard Wei Leon Yip1,2 1Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore; 2Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SingaporeCorrespondence: Vivien Cherng Hui Yip, Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore, Tel +65 62566011, Email vyip82@yahoo.co.ukAim: This study aims to compare the efficacy and safety of combined phacoemulsification with iStent inject (Phaco-iStent) and Hydrus microstent (Phaco-Hydrus).Methods: This was a retrospective comparative study of patients who underwent Phaco-iStent from April 2019 to August 2020 and Phaco-Hydrus from August 2019 to December 2020 at a tertiary eye centre in Singapore. Sixty-nine Phaco-iStent eyes and 49 Phaco-Hydrus eyes were included in this study. Complete surgical success was defined as freedom from second glaucoma surgery, Intraocular pressure (IOP) of 18 mmHg or less, and discontinuation of all antiglaucoma medications.Results: At 12 months, both Phaco-iStent and Phaco-Hydrus groups had comparable surgical success rate (68.1% vs 51%, p=0.061), reduction in antiglaucoma medication use (− 1.3 ± 0.1 vs − 1.4 ± 0.10, p=0.880) and intraocular pressure reduction (− 1.1 ± 0.5 mmHg vs – 1.6 ± 0.9 mmHg, p=0.323). Overall intraoperative and postoperative complications rate were similar in both groups, though hyphema was more commonly seen in early postoperative period in the Phaco-Hydrus compared to the Phaco-iStent group (8% vs 0%, p=0.028), with majority of cases resolving without any need for surgical intervention. Device obstruction was also more common in the Phaco-Hydrus group compared to the Phaco-iStent group (14% vs 4.3%, p=0.04).Conclusion: Phaco-iStent and Phaco-Hydrus have similar surgical efficacy and safety profiles at 12 months.Keywords: glaucoma, phacoemulsification, cataract extraction, iStent inject, Hydrus microstent

Published
2023

11. Diagnostic Accuracies of a Smartphone-Based Fundus Photography and Tablet-Based Visual Field Testing

Author

Patricia Anne S. Tecson MD, MBA, Victor Jose L. Caparas MD, MPh, and Rainier Victor A. Covar, MD, MMed

Subjects
teleglaucoma, melbourne rapid fields, remote diagnosis, iphone fundus photo, Ophthalmology, RE1-994
Abstract

Objective: We determined the diagnostic accuracies of the mydriatic, monoscopic, iPhone 6s+ optic nerve photographs with a 20D lens and the Melbourne Rapid Fields (MRF) visual fields iPad application. Methods: This was a prospective, cross-sectional, single-center study involving 47 non-glaucomatous and 49 glaucomatous eyes. Each eye underwent 2 visual field tests: MRF iPad application and the Humphrey Field Analyzer (HRF). Mydriatic photographs of the fundus were taken with two devices: an iPhone 6s+ combined with a 20 D lens and the Visucam 500 fundus camera. All printouts were evaluated by 2 independent, masked glaucoma specialists. Diagnostic accuracies between the modalities were computed. Agreements between different parameters of both devices were analyzed using Cohen’s kappa test. Results: Smartphone-based (iPhone 6s+) fundus photos had an overall sensitivity of 100%, specificity of 89.36%, positive predictive value (PPV) of 89.36% and negative predictive value (NPV) of 100%, with all kappa values between graders of each parameter above 0.61. Tablet-based Melbourne Rapid Fields test had a sensitivity of 81.82%, specificity of 86.54%, PPV of 83.72% and NPV of 84.91%, showing good agreement with the HRF with a kappa value of 0.68 ± 0.07. Conclusion: Smartphone-based fundus photography and tablet-based visual field tests are comparable to the standard fundus photos and visual field tests in evaluating the optic nerve and visual field. These portable devices are reliable and appropriate tools for diagnosing glaucoma and can be used for documentation and testing in remote areas and in a wider range of settings.

Published
2022

12. A prospective observational study on impact of epinephrine administration route on acute myocardial infarction patients with cardiac arrest in the catheterization laboratory (iCPR study)

Author

Ali Aldujeli, Ayman Haq, Kristen M. Tecson, Zemyna Kurnickaite, Karolis Lickunas, Som Bailey, Vacis Tatarunas, Rima Braukyliene, Giedre Baksyte, Montazar Aldujeili, Hussein Khalifeh, Kasparas Briedis, Rasa Ordiene, Ramunas Unikas, Anas Hamadeh, and Emmanouil S. Brilakis

Subjects
Intracoronary epinephrine, Cardiopulmonary resuscitation, Cardiac arrest, Acute myocardial infarction, Stent thrombosis, Return of spontaneous circulation (ROSC), Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Epinephrine is routinely utilized in cardiac arrest; however, it is unclear if the route of administration affects outcomes in acute myocardial infarction patients with cardiac arrest. Objectives To compare the efficacy of epinephrine administered via the peripheral intravenous (IV), central IV, and intracoronary (IC) routes. Methods Prospective two-center pilot cohort study of acute myocardial infarction patients who suffered cardiac arrest in the cardiac catheterization laboratory during percutaneous coronary intervention. We compared the outcomes of patients who received epinephrine via peripheral IV, central IV, or IC. Results 158 participants were enrolled, 48 (30.4%), 50 (31.6%), and 60 (38.0%) in the central IV, IC, and peripheral IV arms, respectively. Peripheral IV epinephrine administration route was associated with lower odds of achieving return of spontaneous circulation (ROSC, odds ratio = 0.14, 95% confidence interval = 0.05–0.36, p

Published
2022
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13. Class effects of SGLT2 inhibitors on cardiorenal outcomes

Author

Kluger, Aaron Y, Tecson, Kristen M, Lee, Andy Y, Lerma, Edgar V, Rangaswami, Janani, Lepor, Norman E, Cobble, Michael E, and McCullough, Peter A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cardiovascular, Clinical Research, Kidney Disease, Clinical Trials and Supportive Activities, Diabetes, Heart Disease, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, Benzhydryl Compounds, Canagliflozin, Cardiovascular Diseases, Cardiovascular System, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Disease Progression, Glucosides, Humans, Kidney, Protective Factors, Randomized Controlled Trials as Topic, Renal Insufficiency, Chronic, Risk Assessment, Risk Factors, Sodium-Glucose Transporter 2 Inhibitors, Time Factors, Treatment Outcome, SGLT2 inhibitor, Empagliflozin, Dapagliflozin, CANVAS, EMPA-REG OUTCOME, DECLARE-TIMI 58, CREDENCE, Cardiovascular outcome trials, Heart failure hospitalization, Cardiovascular death, Albuminuria, Estimated glomerular filtration function, Chronic kidney disease, End-stage renal disease, Mortality, EMPA–REG OUTCOME, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundTo summarize the four recent sodium-glucose cotransporter 2 inhibitor (SGLT2i) trials: Dapagliflozin Effect on CardiovascuLAR Events (DECLARE-TIMI 58), CANagliflozin CardioVascular Assessment Study (CANVAS) Program, Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients-Removing Excess Glucose (EMPA-REG OUTCOME), Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE), and explore the potential determinants for their cardiovascular, renal, and safety outcomes.ResultsThe composite renal outcome event rates per 1000 patient-years for drug and placebo, as well as the corresponding relative risk reductions, were 3.7, 7.0, 47%; 5.5, 9.0, 40%; 6.3, 11.5, 46%; 43.2, 61.2, 30% for DECLARE-TIMI 58, CANVAS, EMPA-REG OUTCOME, and CREDENCE, respectively (event definitions varied across trials). The major adverse cardiovascular (CV) event rates per 1000 patient-years for drug and placebo, as well as the corresponding relative risk reductions, were 22.6, 24.2, 7%; 26.9, 31.5, 14%; 37.4, 43.9, 14%; 38.7, 48.7, 20% for DECLARE-TIMI 58, CANVAS, EMPA-REG OUTCOME, and CREDENCE, respectively. DECLARE-TIMI 58 had the fewest cardiorenal events and CREDENCE the most. These differences were presumably due to varying inclusion criteria resulting in DECLARE-TIMI 58 having the best baseline renal filtration function and CREDENCE the worst (mean estimated glomerular filtration rate 85.2, 76.5, 74, 56.2 mL/min/1.73 m2 for DECLARE-TIMI 58, CANVAS, EMPA-REG OUTCOME, and CREDENCE, respectively). Additionally, CREDENCE had considerably higher rates of albuminuria (median urinary albumin-creatinine ratios (UACR) were 927, 12.3, and 13.1 mg/g for CREDENCE, CANVAS, and DECLARE-TIMI 58, respectively; EMPA-REG OUTCOME had 59.4% UACR  30-300, 11.0% UACR > 300 mg/g).ConclusionsDapagliflozin, empagliflozin, and canagliflozin have internally and externally consistent and biologically plausible class effects on cardiorenal outcomes. Baseline renal filtration function and degree of albuminuria are the most significant indicators of risk for both CV and renal events. Thus, these two factors also anticipate the greatest clinical benefit for SGLT2i.

Published
2019

14. Prospective 12-month outcomes of combined iStent inject implantation and phacoemulsification in Asian eyes with normal tension glaucoma

Author

Bryan Chin Hou Ang, Wenqi Chiew, Vivien Cherng Hui Yip, Chun Hau Chua, Wei Shan Han, Ivan O’Neill C. Tecson, Jeanne Joyce Ogle, Boon Ang Lim, Owen Kim Hee, Elton Lik Yong Tay, Vernon Khet Yau Yong, Hon Tym Wong, and Leonard Wei Leon Yip

Subjects
iStent inject, Normal tension glaucoma, Minimally invasive glaucoma surgery, Asian, Ophthalmology, RE1-994
Abstract

Abstract Background Glaucoma is the leading cause of irreversible blindness. Normal tension glaucoma (NTG) is a subset of open-angle glaucoma, demonstrating glaucomatous optic nerve damage in the absence of raised intraocular pressure (IOP). NTG is more prevalent in Asian populations. While generally slow-progressing, NTG may be associated with significant central visual field loss. In recent years, minimally invasive glaucoma surgery has been added to the armamentarium of glaucoma surgery. This prospective study aims to evaluate 12-month surgical outcomes of combined iStent inject (Glaukos Corporation, Laguna Hills, CA) implantation and phacoemulsification in Asian eyes with NTG. Methods This is a prospective, single-centre case series of 30 eyes followed up until 12 months after surgery. Outcome measures included IOP, number of glaucoma medications, best-corrected visual acuity (BCVA) and intra and postoperative complications. Results Mean age of subjects was 73.1 ± 6.3 years. Majority were ethnic Chinese (n = 27, 90%). Baseline medicated mean IOP was 13.8 ± 2.4 mmHg and mean number of glaucoma medications was 1.3 ± 0.7. Mean Humphrey visual field mean deviation was − 13.7 ± 7.6. The mean IOP reduction at all timepoints from postoperative month (POM) 3 onwards was statistically significant (all P

Published
2022
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17. A phase 4, multicenter, global clinical study to evaluate discontinuation and rechallenge of pexidartinib in patients with tenosynovial giant cell tumor previously treated with pexidartinib.

Author

Desai, Jayesh, Wagner, Andrew J., Carrasco Garcia, Irene, Cesari, Marilena, Gordon, Michael, Lin, Chia‐Chi, Papai, Zsuzsanna, Ryan, Christopher W., Tap, William D., Trent, Jonathan C., Gelderblom, Hans, Grimison, Peter, López Pousa, Antonio, Van Tine, Brian A., Rubinacci, Maria, Dai, Dong, Rajper, Abdul Waheed, Tecson, Kristen, Wooddell, Margaret, and Stacchiotti, Silvia

Subjects
GIANT cell tumors, VISUAL analog scale, PHYSICAL mobility, SURVIVAL rate, CANCER invasiveness
Abstract

Background: Pexidartinib is effective in patients with tenosynovial giant cell tumor (TGCT) for whom surgery is not feasible. Durability of response after discontinuation of pexidartinib and the safety and efficacy of restarting pexidartinib have not been previously recorded. This phase 4 study was designed to mimic the real‐world experience with pexidartinib to evaluate the effects of discontinuation of and retreatment with pexidartinib in patients with TGCT who previously benefited from the drug. Methods: This was a global, multicenter, phase 4 study that enrolled patients with TGCT who were experiencing clinical benefit from pexidartinib in one of four prior phase 1 or phase 3 studies investigating pexidartinib in the disease. Patients could choose to continue pexidartinib at the same dose (the treatment‐continuation cohort) or discontinue treatment with the option to restart pexidartinib (the treatment‐free/retreatment cohort). Tumor progression determined by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, patient‐reported outcomes (the Patient‐Reported Outcomes Measurement Information System–Physical Function [PROMIS‐PF] questionnaire and the EuroQol 5‐dimension, 5‐level [EQ‐5D‐5L] visual analog scale), and safety were assessed every 3 months. The primary end point was the proportion of patients in the treatment‐free/retreatment cohort who remained treatment‐free at month 12 and 24; this did not depend on disease progression. Results: Thirty‐two patients were enrolled: 21 chose to enter the treatment‐continuation cohort, and 11 entered the treatment‐free/retreatment cohort. During the treatment‐free period, six of 11 (54.5%) patients in the treatment‐free/retreatment cohort had progressive disease (PD) according to RECIST, version 1.1, whereas no patient in the treatment‐continuation cohort had disease progression. Over the 24‐month study, three of 11 (27.3%) patients in the treatment‐free/retreatment cohort restarted treatment because of RECIST version 1.1 PD, symptomatic progression, or both (n = 1 each). The probability of remaining treatment‐free in the treatment‐free/retreatment cohort was 73% (95% confidence interval, 37%–90%). In the treatment‐free/retreatment cohort, the median progression‐free survival of the treatment‐free period was 22.8 months (95% confidence interval, 1.6 months to not estimable). By 6 months of retreatment, all retreated patients achieved new disease stabilization with no new safety concerns; two patients had clinically significant improvements in PROMIS‐PF and EQ‐5D‐5L visual analog scale scores. The mean PROMIS‐PF and EQ‐5D‐5L scores remained stable throughout the study. There was no hepatotoxicity and no new safety signal in either cohort. Conclusions: In this small phase 4 study designed to evaluate outcomes in patients who stopped and restarted pexidartinib, 54.5% of patients who discontinued pexidartinib showed PD, with a median progression‐free survival of 22.8 months. Each of the three patients who restarted pexidartinib stopped progressing, and some reported a new gain in physical function. No PD was detected in patients who remained on treatment, and the safety profile did not indicate long‐term hepatotoxicity or any new safety concerns. Plain Language Summary: Pexidartinib is a medication for people with tenosynovial giant cell tumor (TGCT) for whom surgery is not recommended.This study examined what happens when patients stop taking pexidartinib (after it has helped them) to see whether it is safe and effective to restart if needed.Thirty‐two patients were followed for 2 years: 21 chose to continue pexidartinib and did not experience disease progression, while 11 chose to stop pexidartinib; 54.5% of them had disease progression within 2 years.Three patients who stopped pexidartinib restarted treatment after their tumor size increased or their symptoms worsened.Restarting pexidartinib was safe and effective in these patients. [ABSTRACT FROM AUTHOR]

Published
2025
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21. Re-examination of the current distribution of two endemic malkohas from Greater Luzon PAIC, the Philippines

Author

Estephen Balais Fortela and Juan Carlos Tecson Gonzalez

Subjects
Distribution maps, Luzon PAIC, Museum collections, Online anecdotes, Philippine cuckoos, Ecology, QH540-549.5
Abstract

This study was conducted to re-examine the geographic distribution and update the existing maps and distribution data of the two Greater Luzon Philippine malkohas (Lepidogrammus cumingi and Dasylophus superciliosus) derived from museum specimens and online anecdotes. Precise locality of each skin specimen from various museum collections and recent field accounts from various online platforms on the occurrence of these malkohas were collected, plotted, and compared with the existing distribution maps from the BirdLife International using the Quantum Geographic Information System (QGIS) software. Results showed that the data collected on the locations of the two endemic Philippine malkohas revealed that L. cumingi and D. superciliosus exhibited broader range on their distributions compared to the existing BirdLife International distribution data. Furthermore, the collected distribution data also revealed that the subspecies D. s. cagayanensis is not restricted in the northeast region of Cagayan province but also occurs in its southern regions as well as in the provinces of Benguet and Nueva Vizcaya. The updated and generated maps of the distribution of these birds constitutes a significant range extension that will serve as additional information in the proper implementation of conservation management plan of the Philippine Malkohas.

Published
2022
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22. Determinants and Outcomes of Vasoplegia Following Left Ventricular Assist Device Implantation.

Author

Tecson, Kristen, Lima, Brian, Raza, Fayez, Ching, Grace, Lee, Cheng-Han, Felius, Joost, Baxter, Ronald, Still, Sasha, Collier, Justin, Hall, Shelley, Joseph, Susan, and Lee, Andy

Subjects
left ventricular assist device, vasoplegia, Aged, Arterial Pressure, Cardiopulmonary Bypass, Central Venous Pressure, Female, Heart Failure, Heart-Assist Devices, Humans, Male, Middle Aged, Prosthesis Design, Prosthesis Implantation, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Time Factors, Treatment Outcome, Vasoconstrictor Agents, Vasoplegia, Ventricular Function, Left
Abstract

BACKGROUND: Vasoplegia is associated with adverse outcomes following cardiac surgery; however, its impact following left ventricular assist device implantation is largely unexplored. METHODS AND RESULTS: In 252 consecutive patients receiving a left ventricular assist device, vasoplegia was defined as the occurrence of normal cardiac function and index but with the need for intravenous vasopressors within 48 hours following surgery for >24 hours to maintain a mean arterial pressure >70 mm Hg. We further categorized vasoplegia as none; mild, requiring 1 vasopressor (vasopressin, norepinephrine, or high-dose epinephrine [>5 μg/min]); or moderate to severe, requiring ≥2 vasopressors. Predictors of vasoplegia severity were determined using a cumulative logit (ordinal logistic regression) model, and 1-year mortality was evaluated using competing-risks survival analysis. In total, 67 (26.6%) patients developed mild vasoplegia and 57 (22.6%) developed moderate to severe vasoplegia. The multivariable model for vasoplegia severity utilized preoperative Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile, central venous pressure, systolic blood pressure, and intraoperative cardiopulmonary bypass time, which yielded an area under the curve of 0.76. Although no significant differences were noted in stroke or pump thrombosis rates (P=0.87 and P=0.66, respectively), respiratory failure and major bleeding increased with vasoplegia severity (P

Published
2018

27. Impact of COVID-19 Pandemic on Cardiovascular Testing in Asia: The IAEA INCAPS-COVID Study

Author

Einstein, Andrew J., Paez, Diana, Dondi, Maurizio, Better, Nathan, Cerci, Rodrigo, Dorbala, Sharmila, Pascual, Thomas N.B., Raggi, Paolo, Shaw, Leslee J., Villines, Todd C., Vitola, Joao V., Williams, Michelle C., Pynda, Yaroslav, Hinterleitner, Gerd, Lu, Yao, Morozova, Olga, Xu, Zhuoran, Hirschfeld, Cole B., Cohen, Yosef, Goebel, Benjamin, Malkovskiy, Eli, Randazzo, Michael, Choi, Andrew, Lopez-Mattei, Juan, Parwani, Purvi, Nasery, Mohammad Nawaz, Goda, Artan, Shirka, Ervina, Benlabgaa, Rabie, Bouyoucef, Salah, Medjahedi, Abdelkader, Nailli, Qais, Agolti, Mariela, Aguero, Roberto Nicolas, Alak, Maria del Carmen, Alberguina, Lucia Graciela, Arroñada, Guillermo, Astesiano, Andrea, Astesiano, Alfredo, Norton, Carolina Bas, Benteo, Pablo, Blanco, Juan, Bonelli, Juan Manuel, Bustos, Jose Javier, Cabrejas, Raul, Cachero, Jorge, Campisi, Roxana, Canderoli, Alejandro, Carames, Silvia, Carrascosa, Patrícia, Castro, Ricardo, Cendoya, Oscar, Cognigni, Luciano Martin, Collaud, Carlos, Cortes, Claudia, Courtis, Javier, Cragnolino, Daniel, Daicz, Mariana, De La Vega, Alejandro, De Maria, Silvia Teresa, Del Riego, Horacio, Dettori, Fernando, Deviggiano, Alejandro, Dragonetti, Laura, Embon, Mario, Enriquez, Ruben Emilio, Ensinas, Jorge, Faccio, Fernando, Facello, Adolfo, Garofalo, Diego, Geronazzo, Ricardo, Gonza, Natalia, Gutierrez, Lucas, Guzzo, Miguel Angel, Hasbani, Victor, Huerin, Melina, Jäger, Victor, Lewkowicz, Julio Manuel, López De Munaín, Maria Nieves A., Lotti, Jose Maria, Marquez, Alejandra, Masoli, Osvaldo, Masoli, Osvaldo Horacio, Mastrovito, Edgardo, Mayoraz, Matias, Melado, Graciela Eva, Mele, Anibal, Merani, Maria Fernanda, Meretta, Alejandro Horacio, Molteni, Susana, Montecinos, Marcos, Noguera, Eduardo, Novoa, Carlos, Sueldo, Claudio Pereyra, Ascani, Sebastian Perez, Pollono, Pablo, Pujol, Maria Paula, Radzinschi, Alejandro, Raimondi, Gustavo, Redruello, Marcela, Rodríguez, Marina, Rodríguez, Matías, Romero, Romina Lorena, Acuña, Arturo Romero, Rovaletti, Federico, San Miguel, Lucas, Solari, Lucrecia, Strada, Bruno, Traverso, Sonia, Traverzo, Sonia Simona, Espeche, Maria del Huerto Velazquez, Weihmuller, Juan Sebastian, Wolcan, Juan, Zeffiro, Susana, Sakanyan, Mari, Beuzeville, Scott, Boktor, Raef, Butler, Patrick, Calcott, Jennifer, Carr, Loretta, Chan, Virgil, Chao, Charles, Chong, Woon, Dobson, Mark, Downie, D'Arne, Dwivedi, Girish, Elison, Barry, Engela, Jean, Francis, Roslyn, Gaikwad, Anand, Basavaraj, Ashok Gangasandra, Goodwin, Bruce, Greenough, Robert, Hamilton-Craig, Christian, Hsieh, Victar, Joshi, Subodh, Lederer, Karin, Lee, Kenneth, Lee, Joseph, Magnussen, John, Mai, Nghi, Mander, Gordon, Murton, Fiona, Nandurkar, Dee, Neill, Johanne, O'Rourke, Edward, O'Sullivan, Patricia, Pandos, George, Pathmaraj, Kunthi, Pitman, Alexander, Poulter, Rohan, Premaratne, Manuja, Prior, David, Ridley, Lloyd, Rutherford, Natalie, Salehi, Hamid, Saunders, Connor, Scarlett, Luke, Seneviratne, Sujith, Shetty, Deepa, Shrestha, Ganesh, Shulman, Jonathan, Solanki, Vijay, Stanton, Tony, Stuart, Murch, Stubbs, Michael, Swainson, Ian, Taubman, Kim, Taylor, Andrew, Thomas, Paul, Unger, Steven, Upton, Anthony, Vamadevan, Shankar, Van Gaal, William, Verjans, Johan, Voutnis, Demetrius, Wayne, Victor, Wilson, Peter, Wong, David, Wong, Kirby, Younger, John, Feuchtner, Gudrun, Mirzaei, Siroos, Weiss, Konrad, Maroz-Vadalazhskaya, Natallia, Gheysens, Olivier, Homans, Filip, Moreno-Reyes, Rodrigo, Pasquet, Agnès, Roelants, Veronique, Van De Heyning, Caroline M., Ríos, Raúl Araujo, Soldat-Stankovic, Valentina, Stankovic, Sinisa, Albernaz Siqueira, Maria Helena, Almeida, Augusto, Alves Togni, Paulo Henrique, Andrade, Jose Henrique, Andrade, Luciana, Anselmi, Carlos, Araújo, Roberta, Azevedo, Guilherme, Bezerra, Sabbrina, Biancardi, Rodrigo, Grossman, Gabriel Blacher, Brandão, Simone, Pianta, Diego Bromfman, Carreira, Lara, Castro, Bruno, Chang, Tien, Cunali, Fernando, Jr., Cury, Roberto, Dantas, Roberto, de Amorim Fernandes, Fernando, De 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Mesquita, Cláudio Tinoco, Torreao, Jorge, Torres, Rafael, Uellendahl, Marly, Monte, Guilherme Urpia, Veríssimo, Otávia, Cabeda, Estevan Vieira, Pedras, Felipe Villela, Waltrick, Roberto, Zapparoli, Marcello, Naseer, Hamid, Garcheva-Tsacheva, Marina, Kostadinova, Irena, Theng, Youdaline, Abikhzer, Gad, Barette, Rene, Chow, Benjamin, Dabreo, Dominique, Friedrich, Matthias, Garg, Ria, Hafez, Mohammed Nassoh, Johnson, Chris, Kiess, Marla, Leipsic, Jonathon, Leung, Eugene, Miller, Robert, Oikonomou, Anastasia, Probst, Stephan, Roifman, Idan, Small, Gary, Tandon, Vikas, Trivedi, Adwait, White, James, Zukotynski, Katherine, Canessa, Jose, Muñoz, Gabriel Castro, Concha, Carmen, Hidalgo, Pablo, Lovera, Cesar, Massardo, Teresa, Vargas, Luis Salazar, Abad, Pedro, Arturo, Harold, Ayala, Sandra, Benitez, Luis, Cadena, Alberto, Caicedo, Carlos, Moncayo, Antonio Calderón, Gomez, Sharon, Gutierrez Villamil, Claudia T., Jaimes, Claudia, Londoño, Juan, Londoño Blair, Juan Luis, Pabon, Luz, Pineda, Mauricio, Rojas, Juan Carlos, Ruiz, Diego, Escobar, Manuel Valencia, Vasquez, Andres, Vergel, Damiana, Zuluaga, Alejandro, Gamboa, Isabel Berrocal, Castro, Gabriel, González, Ulises, Baric, Ana, Batinic, Tonci, Franceschi, Maja, Paar, Maja Hrabak, Jukic, Mladen, Medakovic, Petar, Persic, Viktor, Prpic, Marina, Punda, Ante, Batista, Juan Felipe, Gómez Lauchy, Juan Manuel, Gutierrez, Yamile Marcos, Menéndez, Rayner, Peix, Amalia, Rochela, Luis, Panagidis, Christoforos, Petrou, Ioannis, Engelmann, Vaclav, Kaminek, Milan, Kincl, Vladimír, Lang, Otto, Simanek, Milan, Abdulla, Jawdat, Bøttcher, Morten, Christensen, Mette, Gormsen, Lars Christian, Hasbak, Philip, Hess, Søren, Holdgaard, Paw, Johansen, Allan, Kyhl, Kasper, Norgaard, Bjarne Linde, Øvrehus, Kristian Altern, Rønnow Sand, Niels Peter, Steffensen, Rolf, Thomassen, Anders, Zerahn, Bo, Perez, Alfredo, Escorza Velez, Giovanni Alejandro, Velez, Mayra Sanchez, Abdel Aziz, Islam Shawky, Abougabal, Mahasen, Ahmed, Taghreed, Allam, Adel, 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Zhu, Li, Alfaro, Ana, Abrihan, Paz, Barroso, Asela, Cruz, Eric, Gomez, Marie Rhiamar, Magboo, Vincent Peter, Medina, John Michael, Obaldo, Jerry, Pastrana, Davidson, Pawhay, Christian Michael, Quinon, Alvin, Tang, Jeanelle Margareth, Tecson, Bettina, Uson, Kristine Joy, Uy, Mila, Kostkiewicz, Magdalena, Kunikowska, Jolanta, Bettencourt, Nuno, Cantinho, Guilhermina, Ferreira, Antonio, Syed, Ghulam, Arnous, Samer, Atyani, Said, Byrne, Angela, Gleeson, Tadhg, Kerins, David, Meehan, Conor, Murphy, David, Murphy, Mark, Murray, John, O'Brien, Julie, Bang, Ji-In, Bom, Henry, Cho, Sang-Geon, Hong, Chae Moon, Jang, Su Jin, Jeong, Yong Hyu, Kang, Won Jun, Kim, Ji-Young, Lee, Jaetae, Namgung, Chang Kyeong, So, Young, Won, Kyoung Sook, Majstorov, Venjamin, Vavlukis, Marija, Salobir, Barbara Gužic, Štalc, Monika, Benedek, Theodora, Benedek, Imre, Mititelu, Raluca, Stan, Claudiu Adrian, Ansheles, Alexey, Dariy, Olga, Drozdova, Olga, Gagarina, Nina, Gulyaev, Vsevolod Milyevich, Itskovich, Irina, 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Lopez, Lumbreras, Luis, Marquez-Cabeza, Juan Javier, Martin, Francisco, Martinez de Alegria, Anxo, Medina, Francisco, Canal, Maria Pedrera, Peiro, Virginia, Pubul-Nuñez, Virginia, Rayo Madrid, Juan Ignacio, Rey, Cristina Rodríguez, Perez, Ricardo Ruano, Ruiz, Joaquín, Hernández, Gertrudis Sabatel, Sevilla, Ana, Zeidán, Nahla, Nanayakkara, Damayanthi, Udugama, Chandraguptha, Simonsson, Magnus, Alkadhi, Hatem, Buechel, Ronny Ralf, Burger, Peter, Ceriani, Luca, De Boeck, Bart, Gräni, Christoph, Juillet de Saint Lager Lucas, Alix, Kamani, Christel H., Kawel-Boehm, Nadine, Manka, Robert, Prior, John O., Rominger, Axel, Vallée, Jean-Paul, Khiewvan, Benjapa, Premprabha, Teerapon, Thientunyakit, Tanyaluck, Sellem, Ali, Kir, Kemal Metin, Sayman, Haluk, Sebikali, Mugisha Julius, Muyinda, Zerida, Kmetyuk, Yaroslav, Korol, Pavlo, Mykhalchenko, Olena, Pliatsek, Volodymyr, Satyr, Maryna, Albalooshi, Batool, Ahmed Hassan, Mohamed Ismail, Anderson, Jill, Bedi, Punit, Biggans, Thomas, Bularga, Anda, 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Attanasio, Lea, Balmer-Swain, Mallory, Bayer, Richard R., Bernheim, Adam, Bhatti, Sabha, Bieging, Erik, Blankstein, Ron, Bloom, Stephen, Blue, Sean, Bluemke, David, Borges, Andressa, Branch, Kelley, Bravo, Paco, Brothers, Jessica, Budoff, Matthew, Bullock-Palmer, Renée, Burandt, Angela, Burke, Floyd W., Bush, Kelvin, Candela, Candace, Capasso, Elizabeth, Cavalcante, Joao, Chang, Donald, Chatterjee, Saurav, Chatzizisis, Yiannis, Cheezum, Michael, Chen, Tiffany, Chen, Jennifer, Chen, Marcus, Clarcq, James, Cordero, Ayreen, Crim, Matthew, Danciu, Sorin, Decter, Bruce, Dhruva, Nimish, Doherty, Neil, Doukky, Rami, Dunbar, Anjori, Duvall, William, Edwards, Rachael, Esquitin, Kerry, Farah, Husam, Fentanes, Emilio, Ferencik, Maros, Fisher, Daniel, Fitzpatrick, Daniel, Foster, Cameron, Fuisz, Tony, Gannon, Michael, Gastner, Lori, Gerson, Myron, Ghoshhajra, Brian, Goldberg, Alan, Goldner, Brian, Gonzalez, Jorge, Gore, Rosco, Gracia-López, Sandra, Hage, Fadi, Haider, Agha, Haider, Sofia, 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2021
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28. Impact of COVID-19 on Cardiovascular Testing in the United States Versus the Rest of the World

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Einstein, Andrew J., Paez, Diana, Dondi, Maurizio, Better, Nathan, Cerci, Rodrigo, Dorbala, Sharmila, Pascual, Thomas N.B., Raggi, Paolo, Shaw, Leslee J., Villines, Todd C., Vitola, Joao V., Williams, Michelle C., Pynda, Yaroslav, Hinterleitner, Gerd, Lu, Yao, Morozova, Olga, Xu, Zhuoran, Hirschfeld, Cole B., Cohen, Yosef, Goebel, Benjamin, Malkovskiy, Eli, Randazzo, Michael, Choi, Andrew, Lopez-Mattei, Juan, Parwani, Purvi, Nasery, Mohammad Nawaz, Goda, Artan, Shirka, Ervina, Benlabgaa, Rabie, Bouyoucef, Salah, Medjahedi, Abdelkader, Nailli, Qais, Agolti, Mariela, Aguero, Roberto Nicolas, Alak, Maria del Carmen, Alberguina, Lucia Graciela, Arroñada, Guillermo, Astesiano, Andrea, Astesiano, Alfredo, Norton, Carolina Bas, Benteo, Pablo, Blanco, Juan, Bonelli, Juan Manuel, Bustos, Jose Javier, Cabrejas, Raul, Cachero, Jorge, Campisi, Roxana, Canderoli, Alejandro, Carames, Silvia, Carrascosa, Patrícia, Castro, Ricardo, Cendoya, Oscar, Cognigni, Luciano Martin, Collaud, Carlos, Cortes, Claudia, Courtis, Javier, Cragnolino, Daniel, Daicz, Mariana, De La Vega, Alejandro, De Maria, Silvia Teresa, Del Riego, Horacio, Dettori, Fernando, Deviggiano, Alejandro, Dragonetti, Laura, Embon, Mario, Enriquez, Ruben Emilio, Ensinas, Jorge, Faccio, Fernando, Facello, Adolfo, Garofalo, Diego, Geronazzo, Ricardo, Gonza, Natalia, Gutierrez, Lucas, Guzzo, Miguel Angel, Hasbani, Victor, Huerin, Melina, Jäger, Victor, Lewkowicz, Julio Manuel, Nieves A López De Munaín, Maria, Lotti, Jose Maria, Marquez, Alejandra, Masoli, Osvaldo, Masoli, Osvaldo Horacio, Mastrovito, Edgardo, Mayoraz, Matias, Melado, Graciela Eva, Mele, Anibal, Merani, Maria Fernanda, Meretta, Alejandro Horacio, Molteni, Susana, Montecinos, Marcos, Noguera, Eduardo, Novoa, Carlos, Sueldo, Claudio Pereyra, Ascani, Sebastian Perez, Pollono, Pablo, Pujol, Maria Paula, Radzinschi, Alejandro, Raimondi, Gustavo, Redruello, Marcela, Rodríguez, Marina, Rodríguez, Matías, Romero, Romina Lorena, Acuña, Arturo Romero, Rovaletti, 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Bonfiglioli, Rachele, Boni, Roberto, Bruno, Andrea, Bruno, Isabella, Busnardo, Elena, Califaretti, Elena, Camoni, Luca, Carnevale, Aldo, Casoni, Roberta, Cavallo, Armando Ugo, Cavenaghi, Giorgio, Chierichetti, Franca, Chiocchi, Marcello, Cittanti, Corrado, Colletta, Mauro, Conti, Umberto, Cossu, Alberto, Cuocolo, Alberto, Cuzzocrea, Marco, De Rimini, Maria Luisa, De Vincentis, Giuseppe, Del Giudice, Eleonora, Del Torto, Alberico, Della Tommasina, Veronica, Durmo, Rexhep, Erba, Paola Anna, Evangelista, Laura, Faletti, Riccardo, Faragasso, Evelina, Farsad, Mohsen, Ferro, Paola, Florimonte, Luigia, Frantellizzi, Viviana, Fringuelli, Fabio Massimo, Gatti, Marco, Gaudiano, Angela, Gimelli, Alessia, Giubbini, Raffaele, Giuffrida, Francesca, Ialuna, Salvatore, Laudicella, Riccardo, Leccisotti, Lucia, Leva, Lucia, Liga, Riccardo, Liguori, Carlo, Longo, Giampiero, Maffione, Margherita, Mancini, Maria Elisabetta, Marcassa, Claudio, Milan, Elisa, Nardi, Barbara, Pacella, Sara, Pepe, Giovanna, 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Sakata, Sakata Yasushi, Sarai, Masayoshi, Sato, Daisuke, Shiraishi, Shinya, Suwa, Yoshinobu, Takanami, Kentaro, Takehana, Kazuya, Taki, Junichi, Tamaki, Nagara, Taniguchi, Yasuyo, Teragawa, Hiroki, Tomizawa, Nobuo, Tsujita, Kenichi, Umeji, Kyoko, Wakabayashi, Yasushi, Yamada, Shinichiro, Yamazaki, Shinya, Yoneyama, Tatsuya, Rawashdeh, Mohammad, Batyrkhanov, Daultai, Dautov, Tairkhan, Makhdomi, Khalid, Ombati, Kevin, Alkandari, Faridah, Garashi, Masoud, Coie, Tchoyoson Lim, Rajvong, Sonexay, Kalinin, Artem, Kalnina, Marika, Haidar, Mohamad, Komiagiene, Renata, Kviecinskiene, Giedre, Mataciunas, Mindaugas, Vajauskas, Donatas, Picard, Christian, Karim, Noor Khairiah A., Reichmuth, Luise, Samuel, Anthony, Allarakha, Mohammad Aaftaab, Naojee, Ambedhkar Shantaram, Alexanderson-Rosas, Erick, Barragan, Erika, González-Montecinos, Alejandro Becerril, Cabada, Manuel, Rodriguez, Daniel Calderon, Carvajal-Juarez, Isabel, Cortés, Violeta, Cortés, Filiberto, De La Peña, Erasmo, Gama-Moreno, Manlio, 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Abrihan, Paz, Barroso, Asela, Cruz, Eric, Gomez, Marie Rhiamar, Magboo, Vincent Peter, Medina, John Michael, Obaldo, Jerry, Pastrana, Davidson, Pawhay, Christian Michael, Quinon, Alvin, Tang, Jeanelle Margareth, Tecson, Bettina, Uson, Kristine Joy, Uy, Mila, Kostkiewicz, Magdalena, Kunikowska, Jolanta, Bettencourt, Nuno, Cantinho, Guilhermina, Ferreira, Antonio, Syed, Ghulam, Arnous, Samer, Atyani, Said, Byrne, Angela, Gleeson, Tadhg, Kerins, David, Meehan, Conor, Murphy, David, Murphy, Mark, Murray, John, O'Brien, Julie, Bang, Ji-In, Bom, Henry, Cho, Sang-Geon, Hong, Chae Moon, Jang, Su Jin, Jeong, Yong Hyu, Kang, Won Jun, Kim, Ji-Young, Lee, Jaetae, Namgung, Chang Kyeong, So, Young, Won, Kyoung Sook, Majstorov, Venjamin, Vavlukis, Marija, Salobir, Barbara Gužic, Štalc, Monika, Benedek, Theodora, Benedek, Imre, Mititelu, Raluca, Stan, Claudiu Adrian, Ansheles, Alexey, Dariy, Olga, Drozdova, Olga, Gagarina, Nina, Gulyaev, Vsevolod Milyevich, Itskovich, Irina, Karalkin, Anatoly, Kokov, Alexander, Migunova, Ekaterina, Pospelov, Viktor, Ryzhkova, Daria, Saifullina, Guzaliya, Sazonova, Svetlana, Sergienko, Vladimir, Shurupova, Irina, Trifonova, Tatjana, Ussov, Wladimir Yurievich, Vakhromeeva, Margarita, Valiullina, Nailya, Zavadovsky, Konstantin, Zhuravlev, Kirill, Alasnag, Mirvat, Okarvi, Subhani, Saranovic, Dragana Sobic, Keng, Felix, Jason See, Jia Hao, Sekar, Ramkumar, Yew, Min Sen, Vondrak, Andrej, Bejai, Shereen, Bennie, George, Bester, Ria, Engelbrecht, Gerrit, Evbuomwan, Osayande, Gongxeka, Harlem, Vuuren, Magritha Jv, Kaplan, Mitchell, Khushica, Purbhoo, Lakhi, Hoosen, Louw, Lizette, Malan, Nico, Milos, Katarina, Modiselle, Moshe, More, Stuart, Naidoo, Mathava, Scholtz, Leonie, Vangu, Mboyo, Aguadé-Bruix, Santiago, Blanco, Isabel, Cabrera, Antonio, Camarero, Alicia, Casáns-Tormo, Irene, Cuellar-Calabria, Hug, Flotats, Albert, Fuentes Cañamero, Maria Eugenia, García, María Elia, Jimenez-Heffernan, Amelia, Leta, Rubén, Diaz, Javier Lopez, Lumbreras, Luis, Marquez-Cabeza, Juan Javier, Martin, Francisco, Martinez de Alegria, Anxo, Medina, Francisco, Canal, Maria Pedrera, Peiro, Virginia, Pubul-Nuñez, Virginia, Rayo Madrid, Juan Ignacio, Rey, Cristina Rodríguez, Perez, Ricardo Ruano, Ruiz, Joaquín, Hernández, Gertrudis Sabatel, Sevilla, Ana, Zeidán, Nahla, Nanayakkara, Damayanthi, Udugama, Chandraguptha, Simonsson, Magnus, Alkadhi, Hatem, Buechel, Ronny Ralf, Burger, Peter, Ceriani, Luca, De Boeck, Bart, Gräni, Christoph, Juillet de Saint Lager Lucas, Alix, Kamani, Christel H., Kawel-Boehm, Nadine, Manka, Robert, Prior, John O., Rominger, Axel, Vallée, Jean-Paul, Khiewvan, Benjapa, Premprabha, Teerapon, Thientunyakit, Tanyaluck, Sellem, Ali, Kir, Kemal Metin, Sayman, Haluk, Sebikali, Mugisha Julius, Muyinda, Zerida, Kmetyuk, Yaroslav, Korol, Pavlo, Mykhalchenko, Olena, Pliatsek, Volodymyr, Satyr, Maryna, Albalooshi, Batool, Ahmed Hassan, Mohamed Ismail, Anderson, Jill, Bedi, Punit, Biggans, Thomas, Bularga, Anda, Bull, Russell, Burgul, Rajesh, Carpenter, John-Paul, Coles, Duncan, Cusack, David, Deshpande, Aparna, Dougan, John, Fairbairn, Timothy, Farrugia, Alexia, Gopalan, Deepa, Gummow, Alistair, Ramkumar, Prasad Guntur, Hamilton, Mark, Harbinson, Mark, Hartley, Thomas, Hudson, Benjamin, Joshi, Nikhil, Kay, Michael, Kelion, Andrew, Khokhar, Azhar, Kitt, Jamie, Lee, Ken, Low, Chen, Mak, Sze Mun, Marousa, Ntouskou, Martin, Jon, Mcalindon, Elisa, Menezes, Leon, Morgan-Hughes, Gareth, Moss, Alastair, Murray, Anthony, Nicol, Edward, Patel, Dilip, Peebles, Charles, Pugliese, Francesca, Luis Rodrigues, Jonathan Carl, Rofe, Christopher, Sabharwal, Nikant, Schofield, Rebecca, Semple, Thomas, Sharma, Naveen, Strouhal, Peter, Subedi, Deepak, Topping, William, Tweed, Katharine, Weir-Mccall, Jonathan, Abbara, Suhny, Abbasi, Taimur, Abbott, Brian, Abohashem, Shady, Abramson, Sandra, Al-Abboud, Tarek, Al-Mallah, Mouaz, Almousalli, Omar, Ananthasubramaniam, Karthikeyan, Kumar, Mohan Ashok, Askew, Jeffrey, Attanasio, Lea, 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2021
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33. IUBMB/PSBMB 2019 Conference/Plenary: Mentoring in Biochemical Education and Research--Traditional, Structured, and Institutional

Author

Tecson-Mendoza, Evelyn Mae

Abstract

Mentoring to many is the informal highly unstructured teaching, advising, and nurturing which we receive from various individuals during our school years and professional lives and then give back to our students and more junior colleagues. However, with the advances in science and technology, the increasing competitiveness in the workplace, fast pace of life, and globalization, the importance of proper mentoring in the training of science professionals has gained the attention of and has been discussed and studied by higher institutions of learning and national academies of science. During the past two decades, efforts toward making mentoring more structured by national academies of sciences and academic and professional institutions have produced guidelines, mentoring programs for mentors and mentees, faculty, students, scholarly research publications on mentoring, and related aspects. This article attempts to discuss the various aspects and concerns of traditional, structured, and institutional mentoring. [Paper presented at the joint International Union of Biochemistry and Molecular Biology (IUBMB) Education Conference and Philippine Society of Biochemistry and Molecular Biology (PSBMB) Annual Convention (46th) (Manila City, Philippines, Nov 13-15, 2019).]

Published
2020
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35. Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection

Author

McCullough, Peter A., Kelly, Ronan J., Ruocco, Gaetano, Lerma, Edgar, Tumlin, James, Wheelan, Kevin R., Katz, Nevin, Lepor, Norman E., Vijay, Kris, Carter, Harvey, Singh, Bhupinder, McCullough, Sean P., Bhambi, Brijesh K., Palazzuoli, Alberto, De Ferrari, Gaetano M., Milligan, Gregory P., Safder, Taimur, Tecson, Kristen M., Wang, Dee Dee, McKinnon, John E., O'Neill, William W., Zervos, Marcus, and Risch, Harvey A.

Published
2021
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36. Total Makeover: Federal Cosmetics Regulation and Its Need for Legislative Overhaul to Ensure Consumer Protection.

Author

Tecson, Justice

Subjects
Consumer protection -- Laws, regulations and rules -- Standards, Cosmetics industry -- Laws, regulations and rules, United States. Food and Drug Administration -- Management -- Standards, Government regulation, Company business management, Food, Drug and Cosmetic Act
Abstract

"History has repeatedly shown that when there is insufficient regulatory oversight, a few unscrupulous people or companies will exploit the vulnerable public for profit." (1) INTRODUCTION 128 I. FEDERAL COSMETICS [...]

Published
2021

38. Antibiotic use and risk of Clostridioides difficile infection in patients with inflammatory bowel disease.

Author

Bejcek, Alexis, Ancha, Anupama, Lewis, Megan, Beaver, Ryan, Tecson, Kristen, Bomar, Jaccallene, and Johnson, Christopher

Subjects
INFLAMMATORY bowel diseases, CLOSTRIDIOIDES difficile, MACROLIDE antibiotics, CLINDAMYCIN, ODDS ratio
Abstract

Background and Aim: Patients with inflammatory bowel disease (IBD) have an increased risk of Clostridioides difficile infection (CDI) compared with those without IBD, which is worsened with antibiotic usage. While prior studies have shown a correlation between CDI development and certain classes of antibiotics, the IBD population has not been well represented. This study evaluates the rates of CDI with outpatient antibiotic use in patients with IBD. Methods: We conducted a retrospective cohort study composed of patients with IBD and compared the incidence of CDI in patients who received an outpatient prescription for antibiotics (6694 patients) against those without prescriptions (6025 patients) from 2014 to 2020 at our institution. We compared CDI rates based on nine antibiotic classes: penicillins, cephalosporins, sulfonamides, tetracyclines, macrolides, quinolones, clindamycin, metronidazole, and nitrofurantoin. Results: The risk of CDI was low (0.7%) but significantly higher for those with antibiotic exposure (0.9% vs 0.5%, P = 0.005) and had a positive correlation with a smoking history. The increased risk of CDI in the IBD population was attributable to the clindamycin and metronidazole classes (odds ratio = 4.7, 95% confidence interval: 1.9–11.9, P = 0.001; odds ratio = 3.6, 95% confidence interval: 2.1–6.2, P < 0.0001, respectively). Conclusions: The use of clindamycin or metronidazole prescribed in an outpatient setting was associated with a statistically significant increased risk of CDI in patients with IBD. Although the association between clindamycin and CDI is a well‐established and common finding, the association between metronidazole and CDI is unique in this study. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Mortality Risk Assessment Using CHA(2)DS(2)-VASc Scores in Patients Hospitalized With Coronavirus Disease 2019 Infection

Author

Ruocco, Gaetano, McCullough, Peter A., Tecson, Kristen M., Mancone, Massimo, De Ferrari, Gaetano M., D'Ascenzo, Fabrizio, De Rosa, Francesco G., Paggi, Anita, Forleo, Giovanni, Secco, Gioel G., Pistis, Gianfranco, Monticone, Silvia, Vicenzi, Marco, Rota, Irene, Blasi, Francesco, Pugliese, Francesco, Fedele, Francesco, and Palazzuoli, Alberto

Published
2020
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46. Vitamin D deficiency in association with endothelial dysfunction: Implications for patients with COVID-19

Author

Jun Zhang, Peter A. McCullough, Kristen M. Tecson

Subjects
coagulation, covid-19, cytokines, endothelial activation, endothelial dysfunction, inflammation, sars-cov-2, vitamin d, von willebrand factor, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

There is emerging evidence to suggest that vitamin D deficiency is associated with adverse outcomes in COVID-19 patients. Conversely, vitamin D supplementation protects against an initial alveolar diffuse damage of COVID-19 becoming progressively worse. The mechanisms by which vitamin D deficiency exacerbates COVID-19 pneumonia remain poorly understood. In this review we describe the rationale of the putative role of endothelial dysfunction in this event. Herein, we will briefly review (1) anti-inflammatory and anti-thrombotic effects of vitamin D, (2) vitamin D receptor and vitamin D receptor ligand, (3) protective role of vitamin D against endothelial dysfunction, (4) risk of vitamin D deficiency, (5) vitamin D deficiency in association with endothelial dysfunction, (6) the characteristics of vitamin D relevant to COVID-19, (7) the role of vitamin D on innate and adaptive response, (8) biomarkers of endothelial cell activation contributing to cytokine storm, and (9) the bidirectional relationship between inflammation and homeostasis. Finally, we hypothesize that endothelial dysfunction relevant to vitamin D deficiency results from decreased binding of the vitamin D receptor with its ligand on the vascular endothelium and that it may be immune-mediated via increased interferon 1 α. A possible sequence of events may be described as (1) angiotensin II converting enzyme-related initial endothelial injury followed by vitamin D receptor-related endothelial dysfunction, (2) endothelial lesions deteriorating to endothelialitis, coagulopathy and thrombosis, and (3) vascular damage exacerbating pulmonary pathology and making patients with vitamin D deficiency vulnerable to death.

Published
2020
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47. Endothelial dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy

Author

Jun Zhang, Kristen M. Tecson, Peter A. McCullough

Subjects
covid-19, coagulation, cytokines, endothelial dysfunction, sars-cov-2, von willebrand factor, thrombosis, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Great attention has been paid to endothelial dysfunction (ED) in coronavirus disease 2019 (COVID-19). There is growing evidence to suggest that the angiotensin converting enzyme 2 receptor (ACE2 receptor) is expressed on endothelial cells (ECs) in the lung, heart, kidney, and intestine, particularly in systemic vessels (small and large arteries, veins, venules, and capillaries). Upon viral infection of ECs by severe acute respiratory syndrome coronarvirus 2 (SARS-CoV-2), ECs become activated and dysfunctional. As a result of endothelial activation and ED, the levels of pro-inflammatory cytokines (interleukin -1, interleukin-6 (IL-6), and tumor necrosis factor-α), chemokines (monocyte chemoattractant protein-1), von Willebrand factor (vWF) antigen, vWF activity, and factor VIII are elevated. Higher levels of acute phase reactants (IL-6, C-reactive protein, and D-dimer) are also associated with SARS-CoV-2 infection. Therefore, it is reasonable to assume that ED contributes to COVID-19-associated vascular inflammation, particularly endotheliitis, in the lung, heart, and kidney, as well as COVID-19-associated coagulopathy, particularly pulmonary fibrinous microthrombi in the alveolar capillaries. Here we present an update on ED-relevant vasculopathy in COVID-19. Further research for ED in COVID-19 patients is warranted to understand therapeutic opportunities.

Published
2020
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48. Inpatient hospitalisation and mortality rate trends from 2004 to 2014 in the USA: a propensity score-matched case–control study of hyperkalaemia

Author

Peter A McCullough, Kristen Michelle Tecson, Rebecca A Baker, and Laura Clariday

Subjects
Medicine
Abstract

Objective To study the trends of hyperkalaemia in USA inpatient hospitalisation records with heart failure (HF), chronic kidney disease (CKD), acute kidney injury (AKI) and/or type II diabetes mellitus (T2DM) from 2004 to 2014 with respect to prevalence and inpatient mortality.Design Observational cross-sectional and propensity score-matched case–control study.Setting The National Inpatient Sample (representing up to 97% of inpatient hospital discharge records in the USA) from 2004 to 2014Participants 120 513 483 (±2 312 391) adult inpatient hospitalisation records with HF, CKD/end-stage renal disease (ESRD), AKI and/or T2DM.Exposure Hyperkalaemia, defined as the presence of an International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code of ‘276.7’ in any of the first 15 diagnostic codes.Primary and secondary outcome measures The outcomes of interest are the annual rates of hyperkalaemia prevalence and inpatient mortality.Results Among 120 513 483 (±2 312 391) adult inpatient hospitalisations with HF, CKD/ESRD, AKI and/or T2DM, we found a 28.9% relative increase of hyperkalaemia prevalence from 4.94% in 2004 to 6.37% in 2014 (p

Published
2022
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49. 58MO Evaluation of three pexidartinib doses in a global phase IV clinical study of patients with tenosynovial giant cell tumor (TGCT) who chose to continue treatment

Author

Stacchiotti, S, Wagner, AJ, Garcia, ICC, Cesari, M, Gordon, M, Lin, C-C, Papai, Z, Ryan, CW, Tap, WD, Trent, JC, Gelderblom, H, Grimison, P, Pousa, AL, Van Tine, BA, Rubinacci, M, Tecson, K, Wooddell, M, Desai, J, Stacchiotti, S, Wagner, AJ, Garcia, ICC, Cesari, M, Gordon, M, Lin, C-C, Papai, Z, Ryan, CW, Tap, WD, Trent, JC, Gelderblom, H, Grimison, P, Pousa, AL, Van Tine, BA, Rubinacci, M, Tecson, K, Wooddell, M, and Desai, J

Published
2024

50. The Continuous Kidnapping in Pasong Putik, Quezon City

Author

Acibar, Mary Jean, Torres, Feb Marie, Maduro, Rose Anne, Tecson, Wena, Acibar, Mary Jean, Torres, Feb Marie, Maduro, Rose Anne, and Tecson, Wena

Abstract

Kidnapping is a major problem for many law enforcement agencies. The primary objective isto catch all the people behind this kind of illegal activity and protect the person from any threatto his surroundings; the primary target of a perpetrator is women; according to the PhilippineNational Police Anti-Kidnapping Group, every year, we are expecting a hundred cases ofkidnapping in a different part of the Philippines which is the primary victim are women to askfor some ransom and favor in exchange of the life of a victim. Respondents assessed the impact of continuous kidnapping in Pasong Putik, Quezon City.Severe or long terms stress, trauma, neglect, cause of kidnapping in Pasong Putik, QuezonCity, sleep problems, low mood, high levels of anxiety, and other mental health problems canmake it difficult in daily life, Experiencing panic attacks, depression, and schizophrenia,Having problem with memory, reality thinking confusion and concentration.The discussion demonstrates the impact of continuous kidnapping in Pasong Putik QuezonCity on how to address the problem encountered by the respondent, and here are some waysto promote and practice safety. Avoid posting your personal information or your homeaddress, conduct free legal advice to the victim, Conduct a seminar about kidnapping at leastonce a month, Install more CCTV cameras on every corner of the street, And the last rank isCarry any self-defense weapon at all times, sharp object such as a ball pen or pepper sprayhas regarded as (Very Agree)

Published
2024

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