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1. Service delivery challenges in HIV care during the first year of the COVID‐19 pandemic: results from a site assessment survey across the global IeDEA consortium

Author

Brazier, Ellen, Ajeh, Rogers, Maruri, Fernanda, Musick, Beverly, Freeman, Aimee, Wester, C. William, Lee, Man?Po, Shamu, Tinei, Ramírez, Brenda Crabtree, D' Almeida, Marcelline, Wools?Kaloustian, Kara, Kumarasamy, N., Althoff, Keri N., Twizere, Christella, Grinsztejn, Beatriz, Tanser, Frank, Messou, Eugène, Byakwaga, Helen, Duda, Stephany N., Nash, Denis, Chansilpa, Chidchon, Dougherty, Trevor, Karminia, Azar, Law, Matthew, Ross, Jeremy, Sohn, Annette, Aguirre, Ivette, Baker, David, Bloch, Mark, Cabot, Safaa, Carr, Andrew, Couldwell, Deborah, Edwards, Sian, Eu, Beng, Farlow, Heather, Finlayson, Robert, Gunathilake, Manoji, Hazlewood, Cherie, Hoy, Jennifer, Langton?Lockton, Julian, Le, Jacqueline, Leprince, Elizabeth, Minc, Ariane, Moore, Richard, O'Sullivan, Maree, Roth, Norm, Rowling, Dianne, Russell, Darren, Ryder, Nathan, Saunders, Craig, Silvers, Julie, Smith, David J., Sowden, David, Sweeney, Grant, Tan, Lynn, Teague, Ricard, Templeton, David, Thng, Caroline, Woolley, Ian, Khol, Vohith, Ly, Penh Sun, Li, Tsz Hei, Po, Lee Man, Kinikar, Aarti, Kumarasamy, Nagalingeswaran, Mundhe, Sanjay, Pujari, Sanjay, Sangle, Shashikala, Nimkar, Smita, Jassin, Madelein, Kurniati, Nia, Merati, Tuti Parwati, Muktiarti, Dina, Amalia, Rizqi, Sukmawati, Ni Made Dewi Dian, Wati, Ketut Dewi Kumara, Yunihastuti, Evy, Tanuma, Junko, Choi, Jun Yong, Azwa, Raja Iskandar Shah Raja, Cheng, Chan Kwai, Gani, Yasmin Mohamed, Mohamed, Thahira Jamal, Moy, Fong Siew, Nallusamy, Revathy, Nor, Mohamad Zulfahami Mohd, Rudi, Nuraini, Shyan, Wong Peng, Yusoff, Nik Khairulddin Nik, Ditangco, Rossana, Chan, Yu?Jiun, Wu, Pei?Chieh, Wu, Ping?Feng, Avihingsanon, Anchalee, Chaiwarith, Romanee, Chokephaibulkit, Kulkanya, Khusuwan, Suwimon, Kiertiburanakul, Sasisopin, Kosalaraksa, Pope, Lumbiganon, Pagakrong, Ounchanam, Pradtana, Puthanakit, Thanyawee, Rungmaitree, Supattra, Solai, Nuttarika, Sudjaritruk, Tavitiya, An, Vu Thien, Cuong, Do Duy, Do, Chau Viet, Huy, Bui Vu, Quy, Tuan, Van Nguyen, Kinh, Nguyen, Luan, Nguyen, Van Lam, Nguyen, Yen Thi, Nong, Vuong Minh, Truong, Huu Khanh, Tuyen, Ngo Thi Thu, Mcgowan, Catherine C., Duda, Stephany, Cahn, Florencia, Cahn, Pedro, Cesar, Carina, Fink, Valeria, Sued, Omar, Coelho, Lara, Machado, Daisy Maria, Pinto, Jorge, Wolff, Marcelo, Rouzier, Vanessa, Padgett, Denis, Gotuzzo, Eduardo, Biziragusenyuka, Jérémie, Gateretse, Patrick, Nimbona, Pelagie, Niyonkuru, Olive, Twizere, Christelle, Anicetus, Surreng, Djenabou, Amadou, Enow, Priscilla, Mbu, Eyongetah, Manga, Martin, Ndobe, Mercy, Nasah, Judith, Ekossono, Elle Nathalie Syntyche, Bouseko, Mireille Teno, Kitetele, Faustin, Lelo, Patricia, Diafouka, Merlin Isidore Justin, Mafoua, Adolphe, Nsonde, Dominique Mahambou, Bihira, Uitonze Aime Maurice, Dusabe, Marie Chantal, Feza, Rosine, Habanabashaka, Jean Claude, Habumuremyi, Viateur, Igizeneza, Ernestine, Kamigisha, Anne Marie, Kubwimana, Gallican, Maniriho, Gilbert, Mbaraga, Gilbert, Muhoza, Benjamin, Mukakarangwa, Jeanne, Mukamana, Joyce, Mukanyirigira, Patricie, Mukeshimana, Yvone Claude, Munyaneza, Athanase, Murenzi, Gad, Musaninyange, Jacqueline, Nyiraneza, Jules Ndumuhire, Ntarambirwa, Fidele, Nyiraneza, Marie Louise, Tuyishime, Josette, Tuyishimire, Yvonne, Ubandutira, Alexis, Umugiraneza, Florance, Umugwaneza, Rosine, Uwamahoro, Olive, Uwamahoro, Pauline, Uwambaje, Marie Victoire, Uwimpuhwe, Clarisse, Uwiragiye, Siphora, Kuhn, Yee Yee, Adera, Felix, Adhiambo, Beatricec, Aggrey, Khaemba, Akadikor, Daniel, Ambulla, Felix, Apiyo, Dorah, Ariya, Patrick, Atemba, Naftal, Ayodi, Fridah, Benard, Chirchir, Bett, Maureen, Birgen, Serafine, Bwalei, Rael, Chebon, Nancy, Chebor, Valentine Jirry, Chebuiywo, Philip, Chemutai, Jacline, Chepkorir, Emily, Chepseba, Carolyne, Chirchir, John, Diero, Lameck, Dukwa, Benard, Elphas, Alice, Etyang, Tom, Idiama, Agnes, Jebichuko, Ann, Jepchumba, Delvine, Juma, Churchill, Juma, Maureen, Juma, Sheila, Kadima, Julie, Karani, Rose, Keitany, Christopher, Keter, Pricilla, Kiavoga, Lucy, Kibet, Harrison, Kimutai, Ruth, Kiplagat, Mutai, Kiprono, Wilfred, Kipruto, Nicholas Kogei, Kirimi, Asenath, Koech, Zeddy, Kosgei, Carolyne, Kutto, Karen, Kweyu, Mildred, Liech, Ephraim Kenneth, Limo, Milka, Maina, Rose, Marumbu, Priscah, Masese, Agnes, Mochotto, Patricia, Molly, Omudeck, Momanyi, Tom, Murutu, John W., Mwanda, Praxidis, Ndakalu, Lillian, Nderitu, Rose N., Obatsa, Sarah, Obiga, Fredrick, Oboya, Moses, Odhiambo, Joseph, Olaya, George, Omanyala, Oscar, Oray, Christine, Otieno, Molly, Otwane, Modesta Toto, Ouma, Paul, Owuor, Charles, Pepela, Doris Tutu, Pessah, Collins, Rotich, Evans, Rotich, Edwin K., Rutto, Titus C., Shikuku, Monica, Sibweche, Rose Naliaka, Simiyu, Robert Wanyonyi, Siria, Hellen, Some, Michael, Songok, Winnie Cherotich, Tanui, Immaculate, Wafula, Grace, Wambura, Rebecca, Wanjala, Ellah, Wanyama, Carolyne, Wanyonyi, Hellen, Woyakapel, Emmanuel, Zelbabel, Wandera, Gwimo, Dikengela, Kinyota, Ester, Lwali, Jerome, Lyamuya, Rita, Machemba, Richard, Mathias, Julia, Mkombachepa, Lilian, Mokiwa, Athuman, Mushi, Ombeni, Ndunguru, Charles, Ngonyani, Kapella, Nyaga, Charles, Ruta, Happiness, Urassa, Mark, Akanyihayo, James, Arinaitwe, Arnold, Batuuka, Jesca, Birungi, Walusimbi, Bugembe, John Nyanzi, Ddungu, Ahmed, Francis, Kato, Imran, Bangira, Kafuuma, George William, Kalulue, John Bosco, Kanaabi, Grace, Kanyesigye, Michale, Karuhanga, Godfery, Kasozi, Charles, Kasule, Godfrey, Katusime, Assumpta, Kibalama, Donozio, Kimera, Simon Peter, Kulusumu, Namatovu, Lule, Yusuf, Lwanga, Isaac, Mluindwa, Margaret, Moses, Jemba, Mubarak, Sseremba, Muggaga, Daniel, Mukalazi, Evelyn, Muleebwa, Joseph, Mulema, Derick, Musisi, Ivan, Muwawu, John, Muyindike, Winnie, Mwaka, Dick, Naava, Milly, Nabiyki, Immaculate, Nabusulwa, Agnes, Nakabugo, Dorah, Nakamya, Esther, Nakanwagi, Daisy, Nakato, Oliver, Nakayi, Lydian, Nakigozi, Patience, Nakku, Juliet, Nakuya, Juliet, Nakyomu, Justine, Namayanja, Joan, Namirembe, Sarah, Namugumya, Juliet, Namukasa, Ezereth, Namulindwa, Viola, Nankya, Irene, Nannyondo, Grace Mugagga, Nansamba, Harriet, Nansera, Denis, Nanyanzi, Brenda, Nanyonjo, Esther Celina, Nayiga, Irene, Opira, Isaac, Owarwo, Noela C., Resty, Sserunkuma, Semuwemba, Haruna, Senoga, Julius, Sseguya, Gerald, Ssekyewa, John Paul, Ssemakadde, Matthew, Tebajjwa, Jonah, Tugumisirize, Doreen, Tushemerirwe, Robinah, Waliyi, Kawuki, Althoff, Keri, Bishop, Jennifer, Gill, M J., Loutfy, Mona, Smith, Graham, Bamford, Laura, Black, Anthony, Brice, Asia, Brown, Sheldon, Colasanti, Jonathan, Duarte, Piper, Firnhaber, Cynthia, Goetz, Matthew, Grasso, Chris, Gripshover, Barbara, Horberg, Michael, Kelly, Rita, Levine, Ken, Luu, Mitchell, Marconi, Vincent, Maroney, Karen, Mayer, Kenneth, Mayor, Angel, Mcgowan, Catherine, Multani, Ami, Napravnik, Sonia, Nijhawan, Ank, Novak, Richard, Palella, Frank, Rodriguez, Maria C., Scott, Mia, Tedaldi, Ellen, Willig, James, Cornell, Morna, Davies, Mary?Ann, Egger, Matthias, Haas, Andreas, Bereng, Monkoe, Kalake, Maleshoane, Lenela, Keketso, Seretse, Relebohile, Chintenga, Matthews, Chiwoko, Jane, Gumulira, Joe, Huwa, Jacqueline, Maluwa, Rafique, Matanje, Beatrice, Mbewe, Ronald, Mfungwe, Sunshine, Mphande, Zakaliah, Tweya, Hannock, Rafael, Idiovino, Apolles, Patti, Beneke, Eunice, Dlamini, Siphephelo, Edson, Claire, Eley, Brian, Euvrard, Jonathan, Fatti, Geoffrey, Goeieman, Bridgette, Grimwood, Ashraf, Huang, David, Hugo, Susan, Ismail, Zahiera, Jennings, Lauren, Mathenjwa, Thulile, Monteith, Lizette, Mshweshwe, Zamuxolo, Ntuli, Mfundi, Ndlovu, En, Ndlozi, Hloniphile, Noyakaza, Sylvia, Prozesky, Hans, Rabie, Helena, Sipambo, Nosisa, Technau, Karl?Günter, Tembe, Thokozani, Xaba, Nontando, Njobvu, Thandiwe, Munthaly, Mary, Mwetwa, Elly, Kabeba, Gillian, Mwendafilumba, Derrick, Maanguka, Ethel, Manyika, Nelly, Mwansa, Chalwe, Banda, Future, Mwenda, Dickson, Bwalya, Abel, Shapi, Leah, Syame, Kasapo, Sashi, Rita, Mulenga, Chisha, Nanyangwe, Ruth, Chimbetete, Cleophas, Chinofunga, A., Mhike, J., Mubvigwi, E., Nyika, F., Quarter, Kumbirai Pise, Arikawa, Shino Chassagne, Becquet, Renaud, Bernard, Charlotte, Dabis, François, Desmonde, Sophie, Dahourou, Désiré, Ekouevi, Didier Koumavi, Jaquet, Antoine, Jesson, Julie, Leroy, Valeriane, Malateste, Karen, Rabourdin, Elodie, Tiendrebeogo, Thierry, Assogba, Michée, Zannou, Djimon Marcel, Hounhoui, Ghislaine, Bere, Denise, Poda, Armel, Pooda, Gbolo, Traore, Richard, Abauble, Yao, Abby, Ouattara, Acquah, Patrick, Andoble, Valérie, Aude, Yobo N'Dzama, Azani, Jean?Claude, Berete, Oka, Beugre, Jacques Daple, Bohoussou, Caroline Yao, Brou, Simon Boni Emmanuel, Chenal, Henri, Cissé, Abdoulaye, Coulibaly, Nambate, Dainguy, Marie Evelyne, Daligou, Marcelle, D' Aquin, Toni Thomas, Dasse, Claude Desire, Folquet, Madeleine Amorissani, Gnepa, Guy, Gobe, Olivier, Guira, Salif, Hawerlander, Denise, Horo, Apollinaire, Kanga, Guillaume, Messou, Zobo Konan Eugène, Minga, Kla Albert, Moh, Raoul, N'Gbeche, Mariesylvie, Ogbo, Patricia, Oulai, Mathieu, Stéphanie, Se, Eboua, Tanoh, Valère, Itchy Max, Afrane, Adwoa Kumiwa Asare, Akrofi, Esther, Andoh, John Christian, Renner, Lorna, Bagayoko, Awa, Bagayoko, Kadidiatou, Bah, Abdou Salam, Berthe, Alima, Coulibaly, Boureïma, Coulibaly, Fatimata, Coulibaly, Yacouba Aba, Diakité, Aïssata, Bocoum, Fatoumata, Boré, Fatoumata, Dicko, Fatoumata, Koné, Odile, Sylla, Mariam, Tangara, Assitan, Traoré, Mamadou, Seydi, Moussa, Amegatse, Edmond, Djossou, Julienne, Takassi, Elom, and Palanga, Sénam

Subjects
HIV (Viruses) -- Care and treatment -- Patient outcomes, Public health administration -- Evaluation, Health
Abstract

: Introduction: Interruptions in treatment pose risks for people with HIV (PWH) and threaten progress in ending the HIV epidemic; however, the COVID‐19 pandemic's impact on HIV service delivery across diverse settings is not broadly documented. Methods: From September 2020 to March 2021, the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium surveyed 238 HIV care sites across seven geographic regions to document constraints in HIV service delivery during the first year of the pandemic and strategies for ensuring care continuity for PWH. Descriptive statistics were stratified by national HIV prevalence ( Results: Questions about pandemic‐related consequences for HIV care were completed by 225 (95%) sites in 42 countries with low (n = 82), medium (n = 86) and high (n = 57) HIV prevalence, including low‐ (n = 57), lower‐middle (n = 79), upper‐middle (n = 39) and high‐ (n = 50) income countries. Most sites reported being subject to pandemic‐related restrictions on travel, service provision or other operations (75%), and experiencing negative impacts (76%) on clinic operations, including decreased hours/days, reduced provider availability, clinic reconfiguration for COVID‐19 services, record‐keeping interruptions and suspension of partner support. Almost all sites in low‐prevalence and high‐income countries reported increased use of telemedicine (85% and 100%, respectively), compared with less than half of sites in high‐prevalence and lower‐income settings. Few sites in high‐prevalence settings (2%) reported suspending antiretroviral therapy (ART) clinic services, and many reported adopting mitigation strategies to support adherence, including multi‐month dispensing of ART (95%) and designating community ART pick‐up points (44%). While few sites (5%) reported stockouts of first‐line ART regimens, 10–11% reported stockouts of second‐ and third‐line regimens, respectively, primarily in high‐prevalence and lower‐income settings. Interruptions in HIV viral load (VL) testing included suspension of testing (22%), longer turnaround times (41%) and supply/reagent stockouts (22%), but did not differ across settings. Conclusions: While many sites in high HIV prevalence settings and lower‐income countries reported introducing or expanding measures to support treatment adherence and continuity of care, the COVID‐19 pandemic resulted in disruptions to VL testing and ART supply chains that may negatively affect the quality of HIV care in these settings., INTRODUCTION The COVID‐19 pandemic has had major direct and indirect impacts on population health globally, through disruptions in the accessibility and quality of basic health services [1], in supply chains [...]

Published
2022
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2. Mammogram and Pap Smear Uptake Among Women in the HIV Outpatient Study USA, 2010–2021.

Author

Firnhaber, Cynthia, Simoncini, Gina, Mayer, Cynthia, Armon, Carl, Ewing, Alexander C., Tedaldi, Ellen, Battalora, Linda, Carlson, Kimberly, Chagaris, Kalliope, Buchacz, Kate, and Li, Jun

Subjects
BREAST tumor diagnosis, DIAGNOSIS of HIV infections, HIV infection epidemiology, OUTPATIENT services in hospitals, CERVIX uteri tumors, HIV-positive persons, EARLY detection of cancer, PATIENT care, MAMMOGRAMS, PAP test, WOMEN'S health, MEDICAL screening, PATIENTS' attitudes
Published
2024
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4. Incidence of Hyperlipidemia among Adults Initiating Antiretroviral Therapy in the HIV Outpatient Study (HOPS), USA, 2007–2021.

Author

Li, Jun, Agbobli-Nuwoaty, Selom, Palella, Frank J., Novak, Richard M., Tedaldi, Ellen, Mayer, Cynthia, Mahnken, Jonathan D., Hou, Qingjiang, Carlson, Kimberly, Thompson-Paul, Angela M., Durham, Marcus D., and Buchacz, Kate

Abstract

Current U.S. guidelines recommend integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) as initial treatment for people with HIV (PWH). We assessed long-term effects of INSTI use on lipid profiles in routine HIV care. We analyzed medical record data from the HIV Outpatient Study's participants in care from 2007 to 2021. Hyperlipidemia was defined based on clinical diagnoses, treatments, and laboratory results. We calculated hyperlipidemia incidence rates and rate ratios (RRs) during initial ART and assessed predictors of incident hyperlipidemia by using Poisson regression. Among 349 eligible ART-naïve PWH, 168 were prescribed INSTI-based ART (36 raltegravir (RAL), 51 dolutegravir (DTG), and 81 INSTI-others (elvitegravir and bictegravir)) and 181 non-INSTI-based ART, including 68 protease inhibitor (PI)-based ART. During a median follow-up of 1.4 years, hyperlipidemia rates were 12.8, 22.3, 22.7, 17.4, and 12.6 per 100 person years for RAL-, DTG-, INSTI-others-, non-INSTI-PI-, and non-INSTI-non-PI-based ART, respectively. In multivariable analysis, compared with the RAL group, hyperlipidemia rates were higher in INSTI-others (RR = 2.25; 95% confidence interval (CI): 1.29–3.93) and non-INSTI-PI groups (RR = 1.89; CI: 1.12–3.19) but not statistically higher for the DTG (RR = 1.73; CI: 0.95–3.17) and non-INSTI-non-PI groups (RR = 1.55; CI: 0.92–2.62). Other factors independently associated with hyperlipidemia included older age, non-Hispanic White race/ethnicity, and ART without tenofovir disoproxil fumarate. PWH using RAL-based regimens had lower rates of incident hyperlipidemia than PWH receiving non-INSTI-PI-based ART but had similar rates as those receiving DTG-based ART, supporting federal recommendations for using DTG-based regimens as the initial therapy for ART-naïve PWH. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Nice to Your Heart: A Pilot Community-Based Intervention to Improve Heart Health Behaviours in Urban Residents

Author

Carter, Stephanie R., Walker, Alia, Abdul-Latif, Safiyah, Maurer, Laurie, Masunungure, Daniel, Tedaldi, Ellen, and Patterson, Freda

Abstract

Objective: Efforts to improve cardiovascular health among adult African American populations, particularly through organised physical activity, have met with limited success. This study pilot-tested a novel soul line dancing and nutrition education programme ("Nice to Your Heart") that was designed and implemented as part of an academic community-based collaboration. Design: Eight, 2-hour sessions were delivered to 38 eligible and consenting participants. Each session included 60?minutes of soul line dancing and up to 30?minutes of nutrition education. Methods: The outcomes of programme attendance including days physically active and fruit and vegetable consumption in the last week, as well as blood pressure, were assessed. Results: In all, 58% of the sample (N?=?13) attended five or more sessions, with women and those not currently employed more likely to achieve high attendance. Improvements in days active in the last week (t?=?-8.69, p?

Published
2016
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7. Pulmonary effects of immediate versus deferred antiretroviral therapy in HIV-positive individuals: a nested substudy within the multicentre, international, randomised, controlled Strategic Timing of Antiretroviral Treatment (START) trial

Author

Kunisaki, Ken M, Niewoehner, Dennis E, Collins, Gary, Aagaard, Bitten, Atako, Nafisah B, Bakowska, Elzbieta, Clarke, Amanda, Corbelli, Giulio Maria, Ekong, Ernest, Emery, Sean, Finley, Elizabeth B, Florence, Eric, Infante, Rosa M, Kityo, Cissy M, Madero, Juan Sierra, Nixon, Daniel E, Tedaldi, Ellen, Vestbo, Jørgen, Wood, Robin, and Connett, John E

Published
2016
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8. Weight Gain and Metabolic Effects in Persons With HIV Who Switch to ART Regimens Containing Integrase Inhibitors or Tenofovir Alafenamide

Author

Palella, Frank J., primary, Hou, Qingjiang, additional, Li, Jun, additional, Mahnken, Jonathan, additional, Carlson, Kimberly J., additional, Durham, Marcus, additional, Ward, Douglas, additional, Fuhrer, Jack, additional, Tedaldi, Ellen, additional, Novak, Richard, additional, and Buchacz, Kate, additional

Published
2023
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9. Comparison of the Outcomes of Individuals With Medically Attended Influenza A and B Virus Infections Enrolled in 2 International Cohort Studies Over a 6-Year Period: 2009–2015

Author

Dwyer, Dominic E, Lynfield, Ruth, Losso, Marcelo H, Davey, Richard T, Cozzi-Lepri, Alessandro, Wentworth, Deborah, Uyeki, Timothy M, Gordin, Fred, Angus, Brian, Qvist, Tavs, Emery, Sean, Lundgren, Jens, Neaton, James D, Aagaard, Bitten, Borges, Álvaro H D, Cozzi-Lepri, Alessandro, Eid, Marius, Jansson, Per O, Jeppesen, Marianne, Joensen, Zillah Maria, Pedersen, Ruth Kjærgaard, Lundgren, Jens, Nielsen, Birgit Riis, Pearson, Mary, Peters, Lars, Qvist, Tavs, Angus, Brian, Babiker, Abdel, Bennett, Rachel, Braimah, Nafisah, Collaco-Moraes, Yolanda, Cursley, Adam, Hudson, Fleur, Pett, Sarah, Russell, Charlotte, Webb, Helen, Carey, Dianne, Courtney-Rodgers, David, Emery, Sean, Shaw, Pamela, Gordin, Fred, Sanchez, Adriana, Standridge, Barbara, Vjecha, Michael, Brekke, Kate, Campbell, Megan, Denning, Eileen, DuChene, Alain, Engen, Nicole, George, Michelle, Harrison, Merrie, Neaton, James D, Nelson, Ray, Quan, Siu-Fun, Schultz, Terri, Wentworth, Deborah, Baxter, John, Brown, Shawn, Hoover, Marie, Beigel, John, Davey, Richard T, Jr., Dewar, Robin, Gover, Erin, McConnell, Rose, Metcalf, Julia, Natarajan, Ven, Rehman, Tauseef, Voell, Jocelyn, Dwyer, Dominic E, Kok, Jen, Uyeki, Timothy M, Munroe, David, Aguila, Damian, Alzogaray, Maria Fernanda, Ballesteros, Maria Fernanda, Barcan, Laura, Barcelona, Laura, Belloso, Waldo, Berdiñas, Veronica, Bonvehi, Pablo, Caeiro, Juan Pablo, Cisneros, Veronica, Crinejo, Ana, David, Daniel, Doldan, Luz, Ebenrstejin, Juan, Lipari, Flavio, Lopardo, Ana, Lopardo, Gustavo, Losso, Marcelo, Lucchetti, Pablo, Lupo, Sergio, Macias, Laura Moreno, de Tesco, Alejandra Moricz, Mykietiuk, Analia, Nannini, Estaban, Nieto, Gabriel, Nieto, Laura, Peroni, Luciana, Retta, Ignacio, Rodriguez, Patricia, Sanchez, Marisa, Sanchez, Pablo, de Paz Sierra, Mariana, Tavella, Silvina, Temporiti, Elena, Trape, Liliana, Vieni, Ines, Warley, Eduardo, Yahni, Diego, Zarate, Abel Humberto, Avihingsanon, Anchalee, Charoentonpuban, Kanlaya, Chetchotisakd, Ploenchan, Kaewon, Peeraporn, Laopraynak, Naphassanant, Manosuthi, Weerawat, Pussadee, Kanitta, Putcharoen, Opass, Ruxrungtham, Kiat, Suwanpimonkul, Gompol, Ubolyam, Sasiwimol, Arduino, Roberto, Atkinson, Barbara, Aulicino, Taryn M, Baker, Jason V, Bardascino, Cindy, Bass, Caitlin, Baxter, John D, Beilke, Mark, Bentley, Beverly D, Lee Bertrand, Mary, Brown, Ann B, Carbonneau, June, Cindrich, Richard, Coburn, Patty, Cohen, Calvin J, Clark, Linda, Cummins, Shirley, Dassow, Paul, DeHovitz, Jack A, Dharan, Nila J, Faber, Leslie, Farrough, Marti, Freiberg, Matthew, Gardner, Edward, Jo Garrett, Kimberly, Geisler, Christiane, Glesby, Marshall, Green, Julia, Grenade, Joanne, Gunderson, Edie, Gunter, John, Ham, Kirsis, Holman, Susan, Hughes, Valery, Hurt, Christopher, Johnson, Mary, Koerbel, Glory, Koletar, Susan, Lan, Audrey, MacArthur, Rodger, Marcus, Cheryl, Markowitz, Norm, Martinez, Maria Laura, McLaughlin, Karen, Nahra, Raquel, Nettles, Mary Jane, Nixon, Daniel, Novak, Richard, Nuffer, Kathleen, Olivet, Hannah B, Omotosho, Bola, Paez, Armando P, Paez-Quinde, Marta, Parker, Sonija, Patil, Namrata, Polenakovik, Hari, Powell, Sandra, Prosser, Rachel A, Reilly, Nancy A, Riska, Paul F, Rizza, Stacey, Schooley, Robert, Schwarber, Marla, Scott, James, Simon, Gary L, Sivoravong, Jon, Skiest, Daniel J, Solorzano, Clemencia, Sondengam, Rita, Swanson, Nicole, Tedaldi, Ellen, Temesgen, Zelalem, Thomas, Doug, Thron, Bill, Traverse, Colleen, Uddin, David E, Uslan, Daniel Z, Vasco, Marina, Vaughan, William M, Vecino, Isabel, Wade, Barbara, Walker, Catrice, Watson, Kathy, Watson, Vicky, Wohl, David, Wolfe, Cameron R, Andry, Leslie, Bielen, Mireille, Clumeck, Nathan, Florence, Eric, Kabeya, Kabamba, Sagaer, Jolanthe, Weckx, Jozef, Anagnostou, Olga, Antoniadou, Anastasia, Daikos, George, Gioukari, Vicky, Kalomenidis, Ioannis, Kantzanou, Maria, Koratzanis, Georgios, Koulouris, Nikolaos, Maltezos, Efstratios, Metallidis, Symeon, Polixronopoulos, Vlassis, Sambatakou, Helen, Skoutelis, Athanasios, Touloumi, Giota, Vasilopoulos, Nikolaos, Bloch, Mark, Cunningham, Nicky, Dwyer, Dominic E, Edwards, Sian, Elliott, Julian, Garlick, Jill, Habel, Philip, Kilkenny, Fiona, Lau, Helen, MacRae, Karen, McBride, John, Moore, Richard, Prone, Isabel, Ram, Ristila, Richmond, Sue, Roth, Norm, Meng Soo, Tuck, Jo-Anne, Thompson, Vincent, Trina, Vlakahis, Emanuel, Woolstencroft, Rachel, Chadwick, David, Clarke, Tristan, Democratis, Jane, Dockrell, David, Heyderman, Robert, Jeffs, Ben, Kutter, Stefan, Llewelyn, Martin, Minton, Jane, Newport, Melanie, Price, Ashley, Benites, Carlos, Castillo, Raul, Chinchay, Romina, Cornelio, Eva, Guevara, Maria, Gutierrez, Luis, Hidalgo, Jose, La Rosa, Alberto, Pinedo, Yvett, Saenz, Maria, Vega, Juan, Baadegaard, Bente, Bach, Karen, Collins, Philippa, Gerstoft, Jan, Hergens, Lene, Jensen, Lene Pors, Joensen, Zillah Maria, Kronborg, Gitte, Loftheim, Iben Rose, Nielsen, Henrik, Oestergaard, Lars, Pedersen, Court, Stauning Pedersen, Jens Aage, Yehdego, Yordanos, Bergmann, Frank, Boesecke, Christoph, Bogner, Johannes R, Brockmeyer, Norbert, Czaja-Harder, Christine, Draenert, Rika, Fätkenheuer, Gerd, Klinker, Hartwig, Kümmerle, Tim, Lehmann, Clara, Müller, Vera, Plettenberg, Andreas, Rockstroh, Jürgen, Schlabe, Stefan, E Schmidt, Wolfgang, Schürmann, Dirk, Schüttfort, Gundolf, Seybold, Ulrich, Stephan, Christoph, Stoehr, Albrecht, Tillmann, Klaus, Wiebecke, Susanne, Wolf, Timo, Arribas, Jose, Carbone, Javier, Fernández Cruz, Eduardo, Dalmau, David, Estrada, Vincente, Herrero, Patricia, Knobel, Hernando, López, Paco, Montejano, Rocío, Sans Moreno, José, Ramón Paño, José, Portas, Begoña, Rodrigo, Maria, Romero, Pilar, Sánchez-Sendín, Domingo, Soriano, Vincente, Bakowska, Elzbieta, Horban, Andrzej Jerzy, Knysz, Brygida, Kowalska, Karolina Pyziak, Zubkiewicz-Zarebska, Anna, Kase, Kerstin, Mülle, Helen, Zilmer, Kai, Allendes, Gladys, Flores, Jimena, Northland, Rebeka, Perez, Carlos, Velasco, Isabel, Wolff, Marcelo, Chu, Man-Yee, Wu, Tak-chiu, Burgmann, Heinz, Tobudic, Selma, Imahashi, Mayumi, Imamura, Junji, Iwatani, Yasumasa, Kogure, Ayumi, Nakahata, Masashi, Sugiura, Wataru, Yokomaku, Yoshiyuki, and Maagaard, Anne

Published
2017
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15. Trends in use of genotypic resistance testing and frequency of major drug resistance among antiretroviral-naive persons in the HIV Outpatient Study, 1999–2011

Author

Buchacz, Kate, Young, Benjamin, Palella, Frank J., Jr, Armon, Carl, Brooks, John T., Buchacz, Kate, Brooks, John T., Durham, Marcus D., Hays, Harlen, Wood, Kathleen C., Hankerson, Darlene, Hart, Rachel, Subramanian, Thilakavathy, Armon, Carl, Dean, Bonnie, Franklin, Dana, Palella, Frank J., Chmiel, Joan S., Jahangir, Saira, Flaherty, Conor Daniel, Dixon-Evans, Jerian Denise, Lichtenstein, Kenneth A., Stewart, Cheryl, Hammer, John, Greenberg, Kenneth S., Widick, Barbara, Franklin, Rosa, Yangco, Bienvenido G., Chagaris, Kalliope, Ward, Doug, Fuhrer, Jack, Ording-Bauer, Linda, Kelly, Rita, Esteves, Jane, Tedaldi, Ellen M., Christian, Ramona A., Ruley, Faye, Beadle, Dania, Graham, Princess, Novak, Richard M., Wendrow, Andrea, Smith, Renata, Young, Benjamin, Widick, Barbara, and Scott, Mia

Published
2015
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16. Factors associated with mortality among persistently viraemic triple-antiretroviral-class-experienced patients receiving antiretroviral therapy in the HIV Outpatient Study (HOPS)

Author

Palella, Frank J., Jr, Armon, Carl, Buchacz, Kate, Chmiel, Joan S., Novak, Richard M., DʼAquila, Richard T., Brooks, John T., Brooks, John T., Buchacz, Kate, Durham, Marcus D., Wood, Kathleen C., Hankerson, Darlene, Debes, Rachel, Subramanian, Thila, Akridge, Cheryl, Hayes, Harlan, Armon, Carl, Dean, Bonnie, Binkley, Jeff, Bozzette, Sam, Palella, Frank J., Chmiel, Joan S., Studney, Carolyn, Jahangir, Saira, Lichtenstein, Kenneth A., Stewart, Cheryl, Hammer, John, Greenberg, Kenneth S., Widick, Barbara, Franklin, Rosa, Yangco, Bienvenido G., Chagaris, Kalliope, Ward, Doug, Thomas, Troy, Neale, Fletcher, Fuhrer, Jack, Ording-Bauer, Linda, Kelly, Rita, Esteves, Jane, Tedaldi, Ellen M., Christian, Ramona A., Ruley, Faye, Beadle, Dania, Graham, Princess, Novak, Richard M., Wendrow, Andrea, Smith, Renata, Young, Benjamin, Widick, Barbara, and Scott, Mia

Published
2014
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18. Disparities in outcomes for African American and Latino subjects in the Flexible Initial Retrovirus Suppressive Therapies (FIRST) trial

Author

Giordano, Thomas P., Bartsch, Glenn, Zhang, Yafeng, Tedaldi, Ellen, Absalon, Judith, Mannheimer, Sharon, Thomas, Avis, and MacArthur, Rodger D.

Subjects
African Americans -- Health aspects, African Americans -- Comparative analysis, HIV infection -- Drug therapy, HIV infection -- Patient outcomes, HIV infection -- Research, Hispanic Americans -- Health aspects, Hispanic Americans -- Comparative analysis, Health
Abstract

To benefit maximally from antiretroviral therapy, patients with HIV infection must enter care before their disease is advanced and adhere to care. We sought to determine if and where on this continuum of care racial/ethnic disparities were evident. Data from the Flexible Initial Retrovirus Suppressive Therapies (FIRST) trial, which evaluated three strategies for initial HIV therapy, were compared for White, African American, and Latino subjects. Outcomes included progression of disease and death, HIV viral suppression, and change in [CD4.sup.+] cell count. Multivariate Cox proportional hazard models adjusted for known predictors of survival. There were 1357 subjects, including 368 non-Latino white, 751 non-Latino African American, and 238 Latino subjects. At baseline, the two latter groups were more likely to have had AIDS and had lower [CD4.sup.+] cell counts than white subjects. In follow-up, African American subjects had lower self-reported adherence to therapy, lower [CD4.sup.+] cell count increases, and lower odds of viral suppression. African American and Latino subjects had unadjusted hazard ratios of progression of disease or death of 1.57 (1.17, 2.10; p = 0.0025) and 1.57 (1.09, 2.26; p = 0.02), respectively. Adjusting for baseline differences and differences in adherence, [CD4.sup.+] cell count change, and viral suppression accounted for the disparities in outcomes. Opportunities to reduce disparities in outcomes for African American and Latino patients exist along the continuum of HIV care. Efforts to promote access to HIV testing and care and to improve adherence have the potential to reduce racial/ethnic disparities in outcomes of patients with HIV infection. DOI: 10.1089/apc.2009.0332

Published
2010

19. Ezetimibe combined with low-dose statin effectively lowers LDL in protease inhibitor-treated patients

Author

van den Berg-Wolf, Mary, Klibanov, Olga M., Gaughan, John P., and Tedaldi, Ellen M.

Subjects
Statins -- Physiological aspects, Statins -- Dosage and administration, Low density lipoproteins -- Physiological aspects, Health
Abstract

Ezetimibe (EZB) lowers cholesterol by blocking cholesterol absorption in the intestine. Data with EZB are limited in HIV-infected patients. We enrolled HIV-infected adults in this prospective, noncontrolled, single-center pilot study if their low-density lipoprotein (LDL) was not at goal despite therapy with a statin. Stable protease inhibitor (PI)-based highly active antiretroviral therapy (HAART) and a low-dose statin were required for inclusion. The primary endpoint was LDL reduction at 18 weeks. In a subgroup of patients on lopinavir/ritonavir (LPV/r), trough concentrations were obtained before and after addition of EZB. Twenty patients were enrolled; 12 (60%) men, 18 (90%) African American. HAART included ritonavir (RTV)-boosted PIs in 17 (85%) patients; 3 05%) were on nelfinavir. Mean percent changes from baseline in LDL were -10.9%, -12.2%, and -12.4% at weeks 6, 12, and 18, respectively (p 0.05 for each rime period vs. baseline). Mean percent changes from baseline in total cholesterol (TC) were -11.1%, -9.6%, and 9.1% at weeks 6, 12, and 18, respectively (p < 0.05 at each time period vs. baseline). No significant changes in triglycerides, high-density lipoprotein, and LPV/r concentrations were seen. One patient experienced elevated creatine phosphokinase possibly related to study medication; no other adverse effects were seen. Addition of EZB to low-dose statin effectively lowers LDL and TC and appears to be safe and well tolerated.

Published
2008

21. Increased body mass index does not alter response to initial highly active antiretroviral therapy in HIV-1-infected patients

Author

Tedaldi, Ellen M., Brooks, John T., Wiedle, Paul J., Richardson, James T., Baker, Rose K., Buchacz, Kate, Moorman, Anne C., Wood, Kathleen C., and Holmberg, Scott D.

Subjects
Highly active antiretroviral therapy -- Patient outcomes, Body mass index -- Health aspects, Body mass index -- Research, HIV patients -- Health aspects, HIV infection -- Risk factors, Health
Abstract

The effect of body mass index (BMI) on virologic and immunologic response in previously antiretroviral therapy-naive (ART-naive) patients initiating therapy was evaluated. The results indicated that increased BMI was not associated with decreased virologic and immunologic responses to initial highly active antiretroviral therapy (HAART), and responses were equivalent and within expected ranges between normal weight patients, overweight patients and obese patients at 3 to 9 months of observation.

Published
2006

23. Hepatitis A and B vaccination practices for ambulatory patients infected with HIV

Author

Tedaldi, Ellen M., Baker, Rose K., Moorman, Anne C., Wood, Kathleen C., Fuhrer, Jack, McCabe, Robert E., and Holmberg, Scott D.

Subjects
Hepatitis B -- Care and treatment, Hepatitis B -- Research, Hepatitis A -- Care and treatment, Hepatitis A -- Research, HIV infection -- Care and treatment, HIV infection -- Research, Highly active antiretroviral therapy -- Health aspects, Health, Health care industry
Published
2004

25. Prevalence and characteristics of hepatitis C virus coinfection in a human immunodeficiency virus clinical trials group: the Terry Beirn Community Programs for Clinical Research on AIDS. (HIV/AIDS)

Author

Tedaldi, Ellen M., Hullsiek, Katherine Huppler, Malvestutto, Carlos D., Arduino, Roberto C., Fisher, Evelyn J., Gaglio, Paul J., Jenny-Avital, Elizabeth R., McGowan, Joseph P., and Perez, George

Subjects
Comorbidity -- Research, HIV patients -- Diseases, Hepatitis C -- Demographic aspects, Hepatitis C -- Risk factors, Health, Health care industry
Published
2003

26. Influence of coinfection with hepatitis C virus on morbidity and mortality due to human immunodeficiency virus infection in the era of highly active antiretroviral therapy. (Major Article: HIV/AIDS)

Author

Tedaldi, Ellen M., Baker, Rose K., Moorman, Anne C., Alzola, Carlos F., Furhrer, Jack, McCabe, Robert E., Wood, Kathleen C., and Holmberg, Scott D.

Subjects
HIV infection -- Complications, HIV infection -- Patient outcomes, HIV infection -- Development and progression, Highly active antiretroviral therapy -- Physiological aspects, Hepatitis C virus -- Physiological aspects, Health, Health care industry
Published
2003

30. The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

Author

Pereyra, Florencia, Jia, Xiaoming, McLaren, Paul J., Telenti, Amalio, de Bakker, Paul I.W., Walker, Bruce D., Ripke, Stephan, Brumme, Chanson J., Pulit, Sara L, Carrington, Mary, Kadie, Carl M., Carlson, Jonathan M., Heckerman, David, Graham, Robert R., Plenge, Robert M., Deeks, Steven G., Gianniny, Lauren, Crawford, Gabriel, Sullivan, Jordan, Gonzalez, Elena, Davies, Leela, Camargo, Amy, Moore, Jamie M., Beattie, Nicole, Gupta, Supriya, Crenshaw, Andrew, Burtt, Noël P., Guiducci, Candace, Gupta, Namrata, Gao, Xiaojiang, Qi, Ying, Yuki, Yuko, Piechocka-Trocha, Alicja, Cutrell, Emily, Rosenberg, Rachel, Moss, Kristin L., Lemay, Paul, OʼLeary, Jessica, Schaefer, Todd, Verma, Pranshu, Toth, Ildiko, Block, Brian, Baker, Brett, Rothchild, Alissa, Lian, Jeffrey, Proudfoot, Jacqueline, Alvino, Marie L, Vine, Seanna, Addo, Marylyn M., Allen, Todd M., Altfeld, Marcus, Henn, Matthew R., Gall, Sylvie Le, Streeck, Hendrik, Haas, David W., Kuritzkes, Daniel R., Shafer, Robert W., Gulick, Roy M., Shikuma, Cecilia M., Haubrich, Richard, Riddler, Sharon, Sax, Paul E., Daar, Eric S., Ribaudo, Heather J., Agan, Brian, Agarwal, Shanu, Ahem, Richard L, Allen, Brady L., Altidor, Sherly, Altschuler, Eric L, Ambardar, Sujata, Anastos, Kathryn, Anderson, Ben, Anderson, Val, Andrady, Ushan, Antoniskis, Diana, Bangsberg, David, Barbaro, Daniel, Barrie, William, Bartzak, J., Barton, Simon, Basden, Patricia, Basgoz, Nesli, Bazner, Suzane, Bellos, Nicholaos C., Benson, Anne M., Berger, Judith, Bernard, Nicole F., Bemard, Annette M., Birch, Christopher, Bodner, Stanley J., Bolan, Robert K., Boudreaux, Emilie T., Bradley, Meg, Braun, James F., Brndjar, Jon E., Brown, Stephen J., Brown, Katherine, Brown, Sheldon T., Burack, Jedidiah, Bush, Larry M., Cafaro, Virginia, Campbell, Omobolaji, Campbell, John, Carlson, Robert H., Carmichael, Kevin J., Casey, Kathleen K., Cavacuiti, Chris, Celestin, Gregory, Chambers, Steven T., Chez, Nancy, Chirch, Lisa M., Cimoch, Paul J., Cohen, Daniel, Cohn, Lillian E., Conway, Brian, Cooper, David A., Cornelson, Brian, Cox, David T., Cristofano, Michael V., Cuchural, George, Jr., Czartoski, Julie L., Dahman, Joseph M., Daly, Jennifer S., Davis, Benjamin T., Davis, Kristine, Davod, Sheila M., DeJesus, Edwin, Dietz, Craig A., Dunham, Eleanor, Dunn, Michael E., Ellerin, Todd B., Eron, Joseph J., Fangman, John J.W., Farel, Claire E., Ferlazzo, Helen, Fidler, Sarah, Fleenor-Ford, Anita, Frankel, Renee, Freedberg, Kenneth A., French, Neel K., Fuchs, Jonathan D., Fuller, Jon D., Gaberman, Jonna, Gallant, Joel E., Gandhi, Rajesh T., Garcia, Efrain, Garmon, Donald, Gathe, Joseph C., Jr., Gaultier, Cyril R., Gebre, Wondwoosen, Gilman, Frank D., Gilson, Ian, Goepfert, Paul A., Gottlieb, Michael S., Goulston, Claudia, Groger, Richard K., Gurley, Douglas T., Haber, Stuart, Hardwicke, Robin, Hardy, David W., Harrigan, Richard P., Hawkins, Trevor N., Heath, Sonya, Hecht, Frederick M., Henry, Keith W., Hladek, Melissa, Hoffman, Robert P., Horton, James M., Hsu, Ricky K., Huhn, Gregory D., Hunt, Peter, Hupert, Mark J., Illeman, Mark L., Jaeger, Hans, Jellinger, Robert M., John, Mina, Johnson, Jennifer A., Johnson, Kristin L, Johnson, Heather, Johnson, Kay, Joly, Jennifer, Jordan, Wilbert C., Kauffman, Carol A., Khanlou, Homayoon, Kiltian, Robert K., Kim, Arthur Y., Kim, David D., Kinder, Clifford A., Kirchner, Jeffrey T., Kogelman, Laura, Kojic, Ema Milunka, Korthuis, Todd P., Kurisu, Wayne, Kwon, Douglas S., LaMar, Melissa, Lampiris, Harry, Lanzafame, Massimiliano, Lederman, Michael M., Lee, David M., Lee, Jean M.L, Lee, Marah J., Lee, Edward T.Y., Lemoine, Janice, Levy, Jay A., Llibre, Josep M., Liguori, Michael A., Little, Susan J., Liu, Anne Y., Lopez, Alvaro J., Loutfy, Mono R., Loy, Dawn, Mohammed, Debbie Y., Man, Alan, Mansour, Michael K., Marconi, Vincent C., Markowitz, Martin, Marques., Rui, Martin, Jeffrey N., Martin, Harold L., Jr., Mayer, Kenneth Hugh, McElrath, Juliana M., McGhee, Theresa A, McGovem, Barbara H., McGowan, Katherine, Mclntyre, Dawn, Mcleod, Gavin X., Menezes, Prema, Mesa, Greg, Metroka, Craig E., Meyer-Olson, Dirk, Miller, Andy O., Montgomery, Kate, Mounzer, Karam C., Nagami, Ellen H., Nagin, Iris, Nahass, Ronald G., Nelson, Margret O., Nielsen, Craig, Norene, David L, OʼConnor, David H., Ojikutu, Bisola O., Okulicz, Jason, Oladehin, Olakunle O., Oldfield, Edward C, III, Olender, Susan A., Ostrowski, Mario, Owen, William F., Jr., Pae, Eunice, Parsonnet, Jeffrey, Pavlatos, Andrew M., Perlmutter, Aaron M., Pierce, Michael N., Pincus, Jonathan M., Pisani, Leandro, Price, Lawrence Jay, Proia, Laurie, Prokesch, Richard C., Pujet, Heather Calderon, Ramgopal, Moti, Rathod, Almas, Rausch, Michael, Ravishankar, J., Rhame, Frank S., Richards, Constance Shamuyarira, Richman, Douglas D., Robbins, Gregory K., Rodes, Berta, Rodriguez, Milagros, Rose, Richard C., III, Rosenberg, Eric S., Rosenthal, Daniel, Ross, Polly E., Rubin, David S., Rumbaugh, Elease, Saenz, Luis, Salvaggio, Michelle R., Sanchez, William C., Sanjana, Veeraf M., Santiago, Steven, Schmidt, Wolfgang, Schuitemaker, Hanneke, Sestak, Philip M., Shalit, Peter, Shay, William, Shirvani, Vivian N., Silebi, Vanessa I., Sizemore, James M., Jr., Skolnik, Paul R., Sokol-Anderson, Marcia, Sosman, James M., Stabile, Paul, Stapleton, Jack T., Starrett, Sheree, Stein, Francine, Stellbrink, Hans-Jurgen, Sterman, Lisa F., Stone, Valerie E., Stone, David R., Tambussi, Giuseppe, Taplitz, Randy A., Tedaldi, Ellen M., Theisen, William, Torres, Richard, Tosiello, Lorraine, Tremblay, Cecile, Tribble, Marc A., Trinh, Phuong D., Tsao, Alice, Ueda, Peggy, Vaccaro, Anthony, Valadas, Emilia, Vanig, Thanes J., Vecino, Isabel, Vega, Vilma M., Veikley, Wenoah, Wade, Barbara H., Walworth, Charles, Wanidworanun, Chingchai, Ward, Douglas J., Warner, Daniel A., Weber, Robert D., Webster, Duncan, Weis, Steve, Wheeler, David A., White, David J., Wilkins, Ed, Winston, Alan, Wlodaver, Clifford G., vanʼt Wout, Angelique, Wright, David P., Yang, Otto O., Yurdin, David L, Zabukovic, Brandon W., Zachary, Kimon C., Zeeman, Beth, and Zhao, Meng

Published
2010
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32. Chlamydia and Gonorrhea Incidence and Testing Among Patients in the Human Immunodeficiency Virus Outpatient Study (HOPS), 2007−2017

Author

Li, Jun, primary, Armon, Carl, additional, Palella, Frank J, additional, Novak, Richard M, additional, Ward, Douglas, additional, Purinton, Stacey, additional, Durham, Marcus, additional, Buchacz, Kate, additional, Li, Jun, additional, Durham, Marcus D, additional, Akridge, Cheryl, additional, Rayeed, Nabil, additional, Agbobil-Nuwoaty, Selom, additional, Chagaris, Kalliope, additional, Carlson, Kimberly, additional, Battalora, Linda, additional, Mahnken, Jonathan, additional, Jahangir, Saira, additional, Flaherty, Conor Daniel, additional, Bustamante, Patricia, additional, Hammer, John, additional, Greenberg, Kenneth S, additional, Widick, Barbara, additional, Franklin, Rosa, additional, Ward, Douglas J, additional, Thomas, Troy, additional, Stewart, Cheryl, additional, Fuhrer, Jack, additional, Ording-Bauer, Linda, additional, Kelly, Rita, additional, Esteves, Jane, additional, Tedaldi, Ellen M, additional, Christian, Ramona A, additional, Ruley, Faye, additional, Beadle, Dania, additional, Davenport, Princess, additional, Wendrow, Andrea, additional, Mayer, Stockton, additional, Scott, Mia, additional, Thomas, Billie, additional, Van Slyke, Loraine, additional, Mayer, Cynthia, additional, Beitler, Terry, additional, Maroney, Karen, additional, and Franklin, Denise, additional

Published
2019
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35. Disparities in Treatment with Direct-Acting Hepatitis C Virus Antivirals Persist Among Adults Coinfected with HIV and Hepatitis C Virus in US Clinics, 2010–2018.

Author

Simoncini, Gina M., Hou, Qingjiang, Carlson, Kimberly, Buchacz, Kate, Tedaldi, Ellen, Palella Jr., Frank, Durham, Marcus, Li, Jun, Durham, Marcus D., Akridge, Cheryl, Purinton, Stacey, Agbobil-Nuwoaty, Selom, Chagaris, Kalliope, Armon, Carl, Battalora, Linda, Palella, Frank J., Jahangir, Saira, Flaherty, Conor Daniel, Greenberg, Kenneth S., and Widick, Barbara

Subjects
HIV infections, HIV-positive persons, HEALTH services accessibility, ACQUISITION of data methodology, VIRAL load, AGE distribution, ANTIVIRAL agents, HEPATITIS C, HEALTH status indicators, SOCIOECONOMIC factors, TREATMENT effectiveness, MIXED infections, MEDICAL records, DRUG prescribing, HEALTH insurance, DESCRIPTIVE statistics, LOGISTIC regression analysis, PHYSICIAN practice patterns, OUTPATIENT services in hospitals, LONGITUDINAL method
Abstract

Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection carries substantial risk for all-cause mortality and liver-related morbidity and mortality, yet many persons coinfected with HIV/HCV remain untreated for HCV. We explored demographic, clinical, and sociodemographic factors among participants in routine HIV care associated with prescription of direct-acting antivirals (DAAs). The HIV Outpatient Study (HOPS) is an ongoing longitudinal cohort study of persons with HIV in care at participating clinics since 1993. There are currently eight study sites in six US cities. We analyzed medical records data of HOPS participants diagnosed with HCV since June 2010. Sustained virological response (SVR) was documented with first undetectable HCV viral load (VL). We assessed factors associated with being prescribed DAAs by multi-variable logistic regression and described the cumulative rate of SVR. Among 306 eligible participants, 131 (43%) were prescribed DAA therapy. Factors associated with greater odds of being prescribed DAA were older age, private health insurance, higher CD4 cell count, being a person who injects drugs, and receiving care at publicly funded sites (p < 0.05). Of 127 (97%) participants with at least 1 follow-up HCV VL, 110 (87%) achieved SVR at 12 weeks. Of the total 131 participants, 123 (94%) eventually achieved SVR. Less than half of HIV/HCV coinfected patients in HOPS have been prescribed DAAs. Interventions are needed to address deficits in DAA prescription, including among patients with public or no health insurance, younger age, and lower CD4 cell count. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Gutierrez_et_al_Supplemental_Material_revision20190224 – Supplemental material for Sleep disturbances in HIV-infected patients associated with depression and high risk of obstructive sleep apnea

Author

Jeydith Gutierrez, Tedaldi, Ellen M, Armon, Carl, Vaidahi Patel, Hart, Rachel, and Buchacz, Kate

Subjects
FOS: Veterinary sciences, 111199 Nutrition and Dietetics not elsewhere classified, Cardiology, 170199 Psychology not elsewhere classified, 111799 Public Health and Health Services not elsewhere classified, 110604 Sports Medicine, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology, 111099 Nursing not elsewhere classified, 111708 Health and Community Services, 160807 Sociological Methodology and Research Methods, 111702 Aged Health Care, 111403 Paediatrics, 110904 Neurology and Neuromuscular Diseases, 110203 Respiratory Diseases, 110315 Otorhinolaryngology, 70706 Veterinary Medicine, FOS: Clinical medicine, 110319 Psychiatry (incl. Psychotherapy), FOS: Sociology, FOS: Psychology, 110599 Dentistry not elsewhere classified, 110323 Surgery, 110305 Emergency Medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, Gutierrez_et_al_Supplemental_Material_revision20190224 for Sleep disturbances in HIV-infected patients associated with depression and high risk of obstructive sleep apnea by Jeydith Gutierrez, Ellen M Tedaldi, Carl Armon, Vaidahi Patel, Rachel Hart and Kate Buchacz in SAGE Open Medicine

Published
2019
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37. Continuation of Postpartum Antiretroviral Therapy in a Cohort of Women Infected With Human Immunodeficiency Virus

Author

Tedaldi, Ellen, Willard, Suzanne, Gilmore, Joanne, Holdsworth, Catherine, Dix-Lassiter, Sheila, and Axelrod, Peter

Subjects
Pregnant women -- Health aspects, Pregnant women -- Analysis, HIV (Viruses) -- Health aspects, HIV (Viruses) -- Analysis, Antiviral agents -- Health aspects, Antiviral agents -- Analysis, HIV patients -- Health aspects, HIV patients -- Analysis, HIV infection -- Health aspects, HIV infection -- Analysis, Nurses -- Health aspects, Nurses -- Analysis, Cross infection -- Health aspects, Cross infection -- Analysis, Nosocomial infections -- Health aspects, Nosocomial infections -- Analysis, RNA -- Health aspects, RNA -- Analysis, Patient compliance -- Health aspects, Patient compliance -- Analysis, Highly active antiretroviral therapy -- Health aspects, Highly active antiretroviral therapy -- Analysis, Business, Health, Health care industry, Temple University Hospital
Published
2002

38. Hepatitis C Virus Testing Among Men With Human Immunodeficiency Virus Who Have Sex With Men: Temporal Trends and Racial/Ethnic Disparities.

Author

Li, Jun, Armon, Carl, Palella, Frank J, Tedaldi, Ellen, Novak, Richard M, Fuhrer, Jack, Simoncini, Gina, Carlson, Kimberly, Buchacz, Kate, and Investigators, for the HIV Outpatient Study (HOPS)

Subjects
HIV, HEPATITIS C virus, MEN who have sex with men, VIRAL load, GENERALIZED estimating equations
Abstract

Background National guidelines recommend that sexually active people with human immunodeficiency virus (PWH) who are men who have sex with men (MSM) be tested for hepatitis C virus (HCV) infection at least annually. Hepatitis C virus testing rates vary by race/ethnicity in the general population, but limited data are available for PWH. Methods We analyzed medical records data from MSM in the HIV Outpatient Study at 9 human immunodeficiency virus (HIV) clinics from January 1, 2011 through December 31, 2019. We excluded observation time after documented past or current HCV infection. We evaluated HCV antibody testing in each calendar year among HCV-seronegative MSM, and we assessed testing correlates by generalized estimating equation analyses. Results Of 1829 eligible MSM who were PWH, 1174 (64.2%) were non-Hispanic/Latino white (NHW), 402 (22.0%) non-Hispanic black (NHB), 187 (10.2%) Hispanic/Latino, and 66 (3.6%) of other race/ethnicity. Most were ≥40 years old (68.9%), privately insured (64.5%), with CD4 cell count/mm3 (CD4) ≥350 (77.0%), and with HIV viral load <200 copies/mL (76.9%). During 2011–2019, 1205 (65.9%) had ≥1 HCV antibody test and average annual HCV percentage tested was 30.3% (from 33.8% for NHB to 28.5% for NHW; P <.001). Multivariable factors positively associated (P <.05) with HCV testing included more recent HIV diagnosis, public insurance, lower CD4, prior chlamydia, gonorrhea, syphilis, or hepatitis B virus diagnoses, and elevated liver enzyme levels, but not race/ethnicity. Conclusions Although we found no disparities by race/ethnicity in HCV testing, low overall HCV testing rates indicate suboptimal uptake of recommended HCV testing among MSM in HIV care. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Emerging from the shadows: Trends in HIV ambulatory care, viral load testing, and viral suppression in a U.S. HIV cohort, 2019–2022: Impact of COVID-19 pandemic

Author

Tedaldi, Ellen, Hou, Qingjiang, Armon, Carl, Mahnken, Jonathan D, Palella F, Frank J, Simoncini, Gina, Fuhrer, Jack, Mayer, Cynthia, Ewing, Alexander, Chagaris, Kalliope, Carlson, Kimberly J, Li, Jun, and Buchacz, Kate

Abstract

This article aimed at analyzing the acute impact and the longer-term recovery of COVID-19 pandemic effects on clinical encounter types, HIV viral load (VL) testing, and suppression (HIV VL < 200 copies/mL). This study was a longitudinal cohort study of participants seen during 2019–2022 at nine HIV Outpatient Study (HOPS) sites. Generalized linear mixed models (GLMMs) estimated monthly rates of all encounters, office and telemedicine visits, and HIV VL tests using 2010–2022 data. We examined factors associated with nonsuppressed VL (VL ≥ 200 copies/mL) and not having ambulatory care visits during the pandemic using GLMM for logistic regression with 2017–2022 and 2019–2022 data, respectively. Of 2351 active participants, 76.0% were male, 57.6% aged ≥ 50 years, 40.7% non-Hispanic White, 38.2% non-Hispanic Black, 17.3% Hispanic/Latino, and 51.0% publicly insured. The monthly rates of in-person and telemedicine visits varied during 2020 through mid-year 2022. Multivariable logistic regression showed that persons with no encounters were more likely to be male or have VL ≥ 200 copies/mL. For participants with ≥1 VL test, the prevalence rate of HIV VL ≥ 200 copies/mL during 2020 was close to the rates from 2014 to 2019. The change in probability of viral suppression was not associated with participant’s age, sex, race/ethnicity, or insurance type. In the HOPS, overall patient encounters declined over 2 years during the pandemic with variations in telemedicine and in-person events, with relative maintenance of viral suppression. Ongoing recovery from the impact of COVID-19 on ambulatory care will require continued efforts to improve retention and patient access to medical services.

Published
2024
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41. The HIV Outpatient Study—25 Years of HIV Patient Care and Epidemiologic Research.

Author

Buchacz, Kate, Armon, Carl, Palella, Frank J, Novak, Richard M, Fuhrer, Jack, Tedaldi, Ellen, Ward, Douglas, Mayer, Cynthia, Battalora, Linda, Carlson, Kimberly, Purinton, Stacey, Durham, Marcus, Li, Jun, and Investigators, for the HIV Outpatient Study (HOPS)

Subjects
HIV-positive persons, EPIDEMIOLOGISTS, CD4 lymphocyte count, NON-communicable diseases, HIV infections, CLINICAL epidemiology
Abstract

Background The clinical epidemiology of treated HIV infection in the United States has dramatically changed in the past 25 years. Few sources of longitudinal data exist for people with HIV (PWH) spanning that period. Cohort data enable investigating new exposure and disease associations and monitoring progress along the HIV care continuum. Methods We synthesized key published findings and conducted primary data analyses in the HIV Outpatient Study (HOPS), an open cohort of PWH seen at public and private HIV clinics since 1993. We assessed temporal trends in health outcomes (1993–2017) and mortality (1994–2017) for 10 566 HOPS participants. Results The HOPS contributed to characterizing new conditions (eg, lipodystrophy), demonstrated reduced mortality with earlier HIV treatment, uncovered associations between select antiretroviral agents and cardiovascular disease, and documented remarkable shifts in morbidity from AIDS opportunistic infections to chronic noncommunicable diseases. The median CD4 cell count of participants increased from 244 cells/mm3 to 640 cells/mm3 from 1993 to 2017. Mortality fell from 121 to 16 per 1000 person-years from 1994 to 2017 (P  < .001). In 2010, 83.7% of HOPS participants had a most recent HIV viral load <200 copies/mL, compared with 92.2% in 2017. Conclusions Since 1993, the HOPS has been detecting emerging issues and challenges in HIV disease management. HOPS data can also be used for monitoring trends in infectious and chronic diseases, immunologic and viral suppression status, retention in care, and survival, thereby informing progress toward the Ending the HIV Epidemic initiative. [ABSTRACT FROM AUTHOR]

Published
2020
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44. HIV-Associated Neurocognitive Disorders: The Relationship of HIV Infection with Physical and Social Comorbidities

Author

Tedaldi, Ellen M., Minniti, Nancy L., and Fischer, Tracy

Subjects
Article Subject
Abstract

The prevalence of HIV (human immunodeficiency virus) associated neurocognitive disorders (HAND) will undoubtedly increase with the improved longevity of HIV-infected persons. HIV infection, itself, as well as multiple physiologic and psychosocial factors can contribute to cognitive impairment and neurologic complications. These comorbidities confound the diagnosis, assessment, and interventions for neurocognitive disorders. In this review, we discuss the role of several key comorbid factors that may contribute significantly to the development and progression of HIV-related neurocognitive impairment, as well as the current status of diagnostic strategies aimed at identifying HIV-infected individuals with impaired cognition and future research priorities and challenges.

Published
2015
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48. Disparities in HIV Viral Load Suppression by Race/Ethnicity Among Men Who Have Sex with Men in the HIV Outpatient Study.

Author

Buchacz, Kate, Armon, Carl, Tedaldi, Ellen, Palella, Frank J., Novak, Richard M., Ward, Douglas, Hart, Rachel, Durham, Marcus D., Brooks, John T., and the HIV Outpatient Study Investigators

Abstract

Maximizing the rates of virologic suppression (VS) among gay, bisexual, and other men who have sex with men (MSM) is essential to limiting HIV morbidity and sexual transmission of HIV in the United States. We analyzed data for MSM of non-Hispanic white (white), non-Hispanic black (black), or Hispanic/Latino race/ethnicity in the HIV Outpatient Study (HOPS) at nine U.S. HIV clinics. VS (HIV RNA <50 copies/ml) was measured closest to January 1, 2015. We modeled factors associated with VS among persons prescribed antiretroviral therapy (ART) for ≥6 months and assessed VS for a subset of participants with behavioral interview data. Among 1,303 MSM studied, 24% were black and 11% were Hispanic/Latino. Fewer black than white or Hispanic/Latino MSM had any documented ART use history (92% vs. 99% and 94%, respectively), and fewer had VS (72% vs. 91% and 81%), p < .001. In analyses of MSM prescribed ART, which adjusted for insurance type, duration of ART use, and CD4+ cell count, blacks had lower prevalence of VS than whites [adjusted prevalence ratio (PR) 0.87, confidence interval (95% CI) 0.81–0.93] and Hispanics/Latinos did not (PR 0.95, 95% CI 0.88–1.02). Among 331 MSM with interview data, 6% had no VS, but reported anal sex without a condom with an HIV-uninfected or unknown HIV serostatus male partner in the past 6 months. In this study of HIV-infected MSM, blacks had a significantly lower prevalence of VS than white men. Optimizing HIV care and prevention among all MSM will require addressing underlying risk factors and social determinants of health that contribute to racial/ethnic disparities in HIV outcomes. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Trends of racial and ethnic disparities in virologic suppression among women in the HIV Outpatient Study, USA, 2010-2015.

Author

Geter, Angelica, Sutton, Madeline Y., Armon, Carl, Durham, Marcus D., Jr.Palella, Frank J., Tedaldi, Ellen, Hart, Rachel, Buchacz, Kate, and null, null

Subjects
HIV infections, THERAPEUTICS, ANTIRETROVIRAL agents, ETHNICITY, VIROLOGY, HIV-positive women
Abstract

In the United States, women accounted for 19% of new HIV diagnoses in 2015 and were less likely to reach virologic suppression when compared to men. We assessed trends and disparities in virologic suppression among HIV-positive women to inform HIV treatment strategies. Data were from a prospective cohort of the HIV Outpatient Study and collected at nine United States HIV clinics. We included women aged ≥18 years, with ≥1 visit, who were prescribed antiretroviral therapy, and had ≥1 viral load test performed between 2010 and 2015. We defined virologic suppression as viral load <50 copies/mL and calculated adjusted prevalence ratios (aPR) with 95% confidence intervals (CI) for virologic suppression by race/ethnicity and year of measure. Generalized estimating equations were used for multivariable analyses to assess factors associated with virologic suppression. Among 809 women (median age = 44 years), 482 (60%) were black, 177 (22%) white, 150 (19%) Hispanic/Latina. Virologic suppression was less prevalent among black women (73%) compared with Hispanic/Latina women (83%) and white women (91%). In multivariable analyses, not achieving virologic suppression was more likely among black women (aPR = 2.13; CI = 1.50–3.02) or Hispanic/Latina women (aPR = 1.66; CI = 1.08–2.56) compared with white women, and among women who attended public clinics (aPR = 1.42; CI = 1.07–1.87) compared with those who attended a private clinic. Between 2010 and 2015, virologic suppression among HIV-positive women increased from 68% to 83%, but racial/ethnic disparities persisted. Black and Hispanic/Latina women had significantly lower rates of virologic suppression than white women. Interventions targeting virologic suppression improvement among HIV-positive women of color, especially those who attend public clinics, are warranted. [ABSTRACT FROM AUTHOR]

Published
2018
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