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3. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

Author

Chambers, Edward S, Viardot, Alexander, Psichas, Arianna, Morrison, Douglas J, Murphy, Kevin G, Zac-Varghese, Sagen E K, MacDougall, Kenneth, Preston, Tom, Tedford, Catriona, Finlayson, Graham S, Blundell, John E, Bell, Jimmy D, Thomas, E Louise, Mt-Isa, Shahrul, Ashby, Deborah, Gibson, Glen R, Kolida, Sofia, Dhillo, Waljit S, Bloom, Stephen R, Morley, Wayne, Clegg, Stuart, and Frost, Gary

Published
2015
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5. The effects of dietary supplementation with inulin and inulin‐propionate ester on hepatic steatosis in adults with non‐alcoholic fatty liver disease

Author

Chambers, Edward S., Byrne, Claire S., Rugyendo, Annette, Morrison, Douglas J., Preston, Tom, Tedford, Catriona, Bell, Jimmy D., Thomas, Louise, Akbar, Arne N., Riddell, Natalie E., Sharma, Rohini, Thursz, Mark R., Manousou, Pinelopi, and Frost, Gary

Abstract

The short chain fatty acid (SCFA) propionate, produced through fermentation of dietary fibre by the gut microbiota, has been shown to alter hepatic metabolic processes that reduce lipid storage. We aimed to investigate the impact of raising colonic propionate production on hepatic steatosis in adults with non‐alcoholic fatty liver disease (NAFLD). Eighteen adults were randomized to receive 20 g/d of an inulin‐propionate ester (IPE), designed to deliver propionate to the colon, or an inulin control for 42 days in a parallel design. The change in intrahepatocellular lipid (IHCL) following the supplementation period was not different between the groups (P = 0.082), however, IHCL significantly increased within the inulin‐control group (20.9% ± 2.9% to 26.8% ± 3.9%; P = 0.012; n = 9), which was not observed within the IPE group (22.6% ± 6.9% to 23.5% ± 6.8%; P = 0.635; n = 9). The predominant SCFA from colonic fermentation of inulin is acetate, which, in a background of NAFLD and a hepatic metabolic profile that promotes fat accretion, may provide surplus lipogenic substrate to the liver. The increased colonic delivery of propionate from IPE appears to attenuate this acetate‐mediated increase in IHCL.

Published
2019

6. Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study

Author

Byrne, Claire S, primary, Chambers, Edward S, additional, Preston, Tom, additional, Tedford, Catriona, additional, Brignardello, Jerusa, additional, Garcia-Perez, Isabel, additional, Holmes, Elaine, additional, Wallis, Gareth A, additional, Morrison, Douglas J, additional, and Frost, Gary S, additional

Published
2019
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7. Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial

Author

Chambers, Edward S, primary, Byrne, Claire S, additional, Morrison, Douglas J, additional, Murphy, Kevin G, additional, Preston, Tom, additional, Tedford, Catriona, additional, Garcia-Perez, Isabel, additional, Fountana, Sofia, additional, Serrano-Contreras, Jose Ivan, additional, Holmes, Elaine, additional, Reynolds, Catherine J, additional, Roberts, Jordie F, additional, Boyton, Rosemary J, additional, Altmann, Daniel M, additional, McDonald, Julie A K, additional, Marchesi, Julian R, additional, Akbar, Arne N, additional, Riddell, Natalie E, additional, Wallis, Gareth A, additional, and Frost, Gary S, additional

Published
2019
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8. The effects of dietary supplementation with inulin and inulin‐propionate ester on hepatic steatosis in adults with non‐alcoholic fatty liver disease

Author

Chambers, Edward S., primary, Byrne, Claire S., additional, Rugyendo, Annette, additional, Morrison, Douglas J., additional, Preston, Tom, additional, Tedford, Catriona, additional, Bell, Jimmy D., additional, Thomas, Louise, additional, Akbar, Arne N., additional, Riddell, Natalie E., additional, Sharma, Rohini, additional, Thursz, Mark R., additional, Manousou, Pinelopi, additional, and Frost, Gary, additional

Published
2018
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9. Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised crossover trial

Author

Chambers, Edward S., Byrne, Claire S., Morrison, Douglas J., Murphy, Kevin G., Preston, Tom, Tedford, Catriona, Garcia-Perez, Isabel, Fountana, Sofia, Serrano-Contreras, Jose Ivan, Holmes, Elaine, Reynolds, Catherine J., Roberts, Jordie F., Boyton, Rosemary J., Altmann, Daniel M., McDonald, Julie A. K., Marchesi, Julian R., Akbar, Arne N., Riddell, Natalie E., Wallis, Gareth A., and Frost, Gary S.

Subjects
GUT microbiome, INULIN, INSULIN resistance, ESTERS, LIFE sciences
Published
2019
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10. The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro

Author

Pingitore, Attilio, primary, Chambers, Edward S., additional, Hill, Thomas, additional, Maldonado, Inmaculada Ruz, additional, Liu, Bo, additional, Bewick, Gavin, additional, Morrison, Douglas J., additional, Preston, Tom, additional, Wallis, Gareth A., additional, Tedford, Catriona, additional, Castañera González, Ramón, additional, Huang, Guo C., additional, Choudhary, Pratik, additional, Frost, Gary, additional, and Persaud, Shanta J., additional

Published
2016
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11. Effects of Elevating Colonic Propionate on Liver Fat Content in Adults with Non‐Alcoholic Fatty Liver Disease

Author

Chambers, Edward, primary, Viardot, Alexander, additional, Psichas, Arianna, additional, Morrison, Douglas, additional, Murphy, Kevin, additional, Zac‐Varghese, Sagen, additional, Preston, Tom, additional, Tedford, Catriona, additional, Bell, Jimmy, additional, Thomas, Louise, additional, Dhillo, Waljit, additional, Bloom, Stephen, additional, and Frost, Gary, additional

Published
2015
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12. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

Author

Chambers, Edward S, primary, Viardot, Alexander, additional, Psichas, Arianna, additional, Morrison, Douglas J, additional, Murphy, Kevin G, additional, Zac-Varghese, Sagen E K, additional, MacDougall, Kenneth, additional, Preston, Tom, additional, Tedford, Catriona, additional, Finlayson, Graham S, additional, Blundell, John E, additional, Bell, Jimmy D, additional, Thomas, E Louise, additional, Mt-Isa, Shahrul, additional, Ashby, Deborah, additional, Gibson, Glen R, additional, Kolida, Sofia, additional, Dhillo, Waljit S, additional, Bloom, Stephen R, additional, Morley, Wayne, additional, Clegg, Stuart, additional, and Frost, Gary, additional

Published
2014
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13. Catalytic antibodies: designed and accidental

Author

Suckling, Colin J., primary, Stimson, William H., additional, Proctor, George R., additional, Bence, Laura H., additional, Brooks, Linda, additional, Khalaf, Abedawn L., additional, Tedford, Catriona M., additional, Linaza, Sabin, additional, McGilp, Iain, additional, Maguire, Raymond, additional, and Irvine, June, additional

Published
1993
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15. The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease.

Author

Chambers ES, Byrne CS, Rugyendo A, Morrison DJ, Preston T, Tedford C, Bell JD, Thomas L, Akbar AN, Riddell NE, Sharma R, Thursz MR, Manousou P, and Frost G

Subjects
Adolescent, Adult, Aged, Esters pharmacology, Female, Gastrointestinal Microbiome drug effects, Humans, Lipid Metabolism drug effects, Liver drug effects, Liver metabolism, Male, Middle Aged, Non-alcoholic Fatty Liver Disease metabolism, Non-alcoholic Fatty Liver Disease pathology, Young Adult, Dietary Supplements, Fatty Acids, Volatile pharmacology, Inulin pharmacology, Non-alcoholic Fatty Liver Disease diet therapy, Propionates pharmacology
Abstract

The short chain fatty acid (SCFA) propionate, produced through fermentation of dietary fibre by the gut microbiota, has been shown to alter hepatic metabolic processes that reduce lipid storage. We aimed to investigate the impact of raising colonic propionate production on hepatic steatosis in adults with non-alcoholic fatty liver disease (NAFLD). Eighteen adults were randomized to receive 20 g/d of an inulin-propionate ester (IPE), designed to deliver propionate to the colon, or an inulin control for 42 days in a parallel design. The change in intrahepatocellular lipid (IHCL) following the supplementation period was not different between the groups (P = 0.082), however, IHCL significantly increased within the inulin-control group (20.9% ± 2.9% to 26.8% ± 3.9%; P = 0.012; n = 9), which was not observed within the IPE group (22.6% ± 6.9% to 23.5% ± 6.8%; P = 0.635; n = 9). The predominant SCFA from colonic fermentation of inulin is acetate, which, in a background of NAFLD and a hepatic metabolic profile that promotes fat accretion, may provide surplus lipogenic substrate to the liver. The increased colonic delivery of propionate from IPE appears to attenuate this acetate-mediated increase in IHCL., (© 2018 John Wiley & Sons Ltd.)

Published
2019
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