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1. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial

Author

Li, Jie, Mirza, Sara, Vines, David, Elshafei, Ahmad A, Scott, Brady J, Weiss, Tyler, Kaur, Ramandeep, Harnois, Lauren J, Miller, Amanda, Cerda, Flor, Klein, Andrew, Burd, Jacob R, Posa-Kearney, Kathleen, Trump, Matthew, Jackson, Julie, Oetting, Trevor, Greenwood, Mark, Hazel, Lindsay, Kingery, Lisa, Mogri, Idrees, Morris, Lindsey, Moon, Joon Yong, Garnett, Julianne, Jia, Shijing, Nelson, Kristine, McNicholas, Bairbre, Cosgrave, David, Giacomini, Camilla, Laffey, John, Brennan, Aoife, Judge, Conor, Kernan, Maeve, Kelly, Claire, Ranjan, Ritika, Casey, Siobhan, O'Connell, Kevin, Newell, Evelyn, Gallagher, David, Nichol, Alistair, Curley, Ger, Estrada, Miguel Ibarra, García-Salcido, Roxana, Vargas-Obieta, Alexandra, Aguirre-Avalos, Guadalupe, Aguirre-Díaz, Sara A, Alcántar-Vallín, Luz, Alvarado-Padilla, Montserrat, Chávez-Peña, Quetzalcóatl, López-Pulgarín, José A, Mijangos-Méndez, Julio C, Marín-Rosales, Miguel, García-Alvarado, Jorge E, Baltazar-González, Oscar G, González-Guerrero, Maura C, Gutiérrez Ramírez, Paola G, Pavlov, Ivan, Gilman, Sean, Plamondon, Patrice, Roy, Rachel, Jayaraman, Dev, Shahin, Jason, Ragoshai, Raham, Kaur, Aasmine, Campisi, Josie, Dahine, Joseph, Perron, Stefanie, Achouri, Slimane, Racette, Ronald, Kulenkamp, Anne, Roca, Oriol, Pacheco, Andrés, García-de-Acilu, Marina, Masclans, Joan R, Dot, Irene, Perez, Yonatan, Bodet-Contentin, Laetitia, Garot, Denis, Ehrmann, Stephan, Mercier, Emmanuelle, Salmon Gandonnière, Charlotte, Morisseau, Marlène, Jouan, Youenn, Darwiche, Walid, Legras, Annick, Guillon, Antoine, Tavernier, Elsa, Dequin, Pierre-François, Tellier, Anne-Charlotte, Reignier, Jean, Lascarrou, Jean-Baptiste, Seguin, Amélie, Desmedt, Luc, Canet, Emmanuel, Guitton, Christophe, Marnai, Rémy, Callahan, Jean-Christophe, Landais, Mickaël, Chudeau, Nicolas, Darreau, Cédric, Tirot, Patrice, Saint Martin, Marjorie, Le Moal, Charlene, Nay, Mai-Anh, Muller, Grégoire, Jacquier, Sophie, Prat, Gwenaël, Bailly, Pierre, Ferrière, Nicola, Thille, Arnaud W, Frat, Jean-Pierre, Dellamonica, Jean, Saccheri, Clément, Buscot, Matthieu, Plantefève, Gaëtan, Contou, Damien, Roux, Damien, Ricard, Jean-Damien, Federici, Laura, Zucman, Noémie, Freita Ramos, Santiago, Amouretti, Marc, Besset, Sébastien, Gernez, Coralie, Delbove, Agathe, Voiriot, Guillaume, Elabbadi, Alexandre, Fartoukh, Muriel, Nseir, Saad, Préau, Sébastien, Favory, Raphaël, Pierre, Alexandre, Sement, Arnaud, Terzi, Nicolas, Sigaud, Florian, Candille, Clara, Turbil, Emanuele, Maizel, Julien, Brault, Clément, Zerbib, Yoan, Joret, Aurélie, Daubin, Cédric, Lefebvre, Laurent, Giraud, Alais, Auvet, Adrien, Vinsonneau, Christophe, Marzouk, Mehdi, Quenot, Jean-Pierre, Andreu, Pascal, Labruyère, Marie, Roudaut, Jean-Baptiste, Aptel, François, Boyer, Alexandre, Boyer, Philippe, Lacherade, Jean-Claude, Hille, Hugo, Bouteloup, Marie, Jeannot, Matthieu, Feller, Marc, Grillet, Guillaume, Levy, Bruno, Kimmoun, Antoine, Ibarra-Estrada, Miguel, Garcia-Salcido, Roxana, Trump, Matthew W, and Laffey, John G

Published
2021
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2. Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS

Author

Souweine, Bertrand, Eisenmann, Nathanael, Quenot, Jean-Pierre, Seguin, Philippe, Asehnoune, Karim, Lasocki, Sigismond, Ferrandiere, Martine, Sossou, Achile, Langeron, Olivier, Leone, Marc, Dupont, Herve, Veber, Benoit, Ichai, Carole, Rimmelé, Thomas, Legay, François, Grelon, Fabien, Dahyot-Fizelier, Claire, Cayot, Sophie, Godet, Thomas, Guerin, Renaud, Verlhac, Camille, Chabanne, Russell, Cosserant, Bernard, Blondonnet, Raiko, Lautrette, Alexandre, Muller, Laurent, Massanet, Pablo, Boutin, Caroline, Barbar, Saber, Roger, Claire, Belafia, Fouad, Cisse, Moussa, Monnin, Marion, Conseil, Matthieu, Carr, Julie, De Jong, Audrey, Chanques, Gérald, Dargent, Auguste, Crozon, Thomas, Clauzel, Julien, Le Core, Marinne, Andreu, Pascal, Lebouvrier, Thomas, Launey, Yoann, Roquilly, Antoine, Cinotti, Raphael, Tellier, Anne-Charlotte, Barbaz, Mathilde, Cohen, Benjamin, Lemarche, Edouard, Bertrand, Pierre-Marie, Arbelot, Charlotte, Zieleskiewicz, Laurent, Hammad, Emmanuelle, Duclos, Garry, Calypso, Mathieu, Orban, Jean-Christophe, Quintard, Hervé, Assefi, Mona, Morel, Jerome, Molliex, Serge, Petitas, Frank, Nanadougmar, Hadanou, Jabaudon, Matthieu, Audard, Jules, Pereira, Bruno, Jaber, Samir, Lefrant, Jean-Yves, Futier, Emmanuel, Lambert, Céline, Bazin, Jean-Etienne, Bastarache, Julie A., Constantin, Jean-Michel, and Ware, Lorraine B.

Published
2020
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4. Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial

Author

Landais, Mickaël, primary, Nay, Mai-Anh, additional, Auchabie, Johann, additional, Hubert, Noemie, additional, Frerou, Aurélien, additional, Yehia, Aihem, additional, Mercat, Alain, additional, Jonas, Maud, additional, Martino, Frédéric, additional, Moriconi, Mikael, additional, Courte, Anne, additional, Robert-Edan, Vincent, additional, Conia, Alexandre, additional, Bavozet, Florent, additional, Egreteau, Pierre-Yves, additional, Bruel, Cédric, additional, Renault, Anne, additional, Huet, Olivier, additional, Feller, Marc, additional, Chudeau, Nicolas, additional, Ferrandiere, Martine, additional, Rebion, Anne, additional, Robert, Alain, additional, Giraudeau, Bruno, additional, Reignier, Jean, additional, Thille, Arnaud W, additional, Tavernier, Elsa, additional, Ehrmann, Stephan, additional, MORTAZA, Satar, additional, DEMISELLE, Julien, additional, SASSI, Taoufik, additional, DELALE, Charles, additional, GROUILLE, Julien, additional, DE TINTENIAC, Anne, additional, GESLAIN, Marie, additional, FLOCH, Herve, additional, BAILLY, Pierre, additional, BODENES, Laetitia, additional, PRAT, Gwenaël, additional, KALFON, Pierre, additional, BADRE, Gaetan, additional, JOURDAIN, Cecile, additional, MAZZONI, Thierry, additional, LE MEUR, Anthony, additional, FAYOLLE, Pierre Marie, additional, HERON, Anne, additional, MAILLET, Odile, additional, LEDOUX, Nelly, additional, ROLLE, Amélie, additional, RICHARD, Régine, additional, VALETTE, Marc, additional, AZAIS, Marie-Ange, additional, POUPLET, Caroline, additional, BACHOUMAS, Konstantinos, additional, CALLAHAN, Jean Christophe, additional, GUITTON, Christophe, additional, DARREAU, Cedric, additional, LEFEVRE, Montaine, additional, LELOUP, Guillaume, additional, BERTEL, Mélanie, additional, DAUVERGNE, Jerome, additional, PACAUD, Laurence, additional, LAKHAL, Karim, additional, MARTIN, Maelle, additional, GARRET, Charlotte, additional, LASCARROU, Jean-Baptiste, additional, BOULAIN, Thierry, additional, MATHONNET, Armelle, additional, MULLER, Grégoire, additional, PHILIPPART, François, additional, TRAN, Marc, additional, FOURNIER, Julien, additional, FRAT, Jean-Pierre, additional, COUDROY, Remi, additional, CHATELLIER, Delphine, additional, HALLEY, Guillaume, additional, GACOUIN, Arnaud, additional, HOFF, Jerome, additional, VASTAL, Servane, additional, TELLIER, Anne-Charlotte, additional, BARBAZ, Mathilde, additional, SALMON GANDONNIERE, Charlotte, additional, MERCIER, Emmanuelle, additional, and DARWICHE, Walid, additional

Published
2023
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6. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial

Author

Ehrmann, Stephan, primary, Li, Jie, additional, Ibarra-Estrada, Miguel, additional, Perez, Yonatan, additional, Pavlov, Ivan, additional, McNicholas, Bairbre, additional, Roca, Oriol, additional, Mirza, Sara, additional, Vines, David, additional, Garcia-Salcido, Roxana, additional, Aguirre-Avalos, Guadalupe, additional, Trump, Matthew W, additional, Nay, Mai-Anh, additional, Dellamonica, Jean, additional, Nseir, Saad, additional, Mogri, Idrees, additional, Cosgrave, David, additional, Jayaraman, Dev, additional, Masclans, Joan R, additional, Laffey, John G, additional, Tavernier, Elsa, additional, Elshafei, Ahmad A, additional, Scott, Brady J, additional, Weiss, Tyler, additional, Kaur, Ramandeep, additional, Harnois, Lauren J, additional, Miller, Amanda, additional, Cerda, Flor, additional, Klein, Andrew, additional, Burd, Jacob R, additional, Posa-Kearney, Kathleen, additional, Trump, Matthew, additional, Jackson, Julie, additional, Oetting, Trevor, additional, Greenwood, Mark, additional, Hazel, Lindsay, additional, Kingery, Lisa, additional, Morris, Lindsey, additional, Moon, Joon Yong, additional, Garnett, Julianne, additional, Jia, Shijing, additional, Nelson, Kristine, additional, Giacomini, Camilla, additional, Laffey, John, additional, Brennan, Aoife, additional, Judge, Conor, additional, Kernan, Maeve, additional, Kelly, Claire, additional, Ranjan, Ritika, additional, Casey, Siobhan, additional, O'Connell, Kevin, additional, Newell, Evelyn, additional, Gallagher, David, additional, Nichol, Alistair, additional, Curley, Ger, additional, Estrada, Miguel Ibarra, additional, García-Salcido, Roxana, additional, Vargas-Obieta, Alexandra, additional, Aguirre-Díaz, Sara A, additional, Alcántar-Vallín, Luz, additional, Alvarado-Padilla, Montserrat, additional, Chávez-Peña, Quetzalcóatl, additional, López-Pulgarín, José A, additional, Mijangos-Méndez, Julio C, additional, Marín-Rosales, Miguel, additional, García-Alvarado, Jorge E, additional, Baltazar-González, Oscar G, additional, González-Guerrero, Maura C, additional, Gutiérrez Ramírez, Paola G, additional, Gilman, Sean, additional, Plamondon, Patrice, additional, Roy, Rachel, additional, Shahin, Jason, additional, Ragoshai, Raham, additional, Kaur, Aasmine, additional, Campisi, Josie, additional, Dahine, Joseph, additional, Perron, Stefanie, additional, Achouri, Slimane, additional, Racette, Ronald, additional, Kulenkamp, Anne, additional, Pacheco, Andrés, additional, García-de-Acilu, Marina, additional, Dot, Irene, additional, Bodet-Contentin, Laetitia, additional, Garot, Denis, additional, Ehrmann, Stephan, additional, Mercier, Emmanuelle, additional, Salmon Gandonnière, Charlotte, additional, Morisseau, Marlène, additional, Jouan, Youenn, additional, Darwiche, Walid, additional, Legras, Annick, additional, Guillon, Antoine, additional, Dequin, Pierre-François, additional, Tellier, Anne-Charlotte, additional, Reignier, Jean, additional, Lascarrou, Jean-Baptiste, additional, Seguin, Amélie, additional, Desmedt, Luc, additional, Canet, Emmanuel, additional, Guitton, Christophe, additional, Marnai, Rémy, additional, Callahan, Jean-Christophe, additional, Landais, Mickaël, additional, Chudeau, Nicolas, additional, Darreau, Cédric, additional, Tirot, Patrice, additional, Saint Martin, Marjorie, additional, Le Moal, Charlene, additional, Muller, Grégoire, additional, Jacquier, Sophie, additional, Prat, Gwenaël, additional, Bailly, Pierre, additional, Ferrière, Nicola, additional, Thille, Arnaud W, additional, Frat, Jean-Pierre, additional, Saccheri, Clément, additional, Buscot, Matthieu, additional, Plantefève, Gaëtan, additional, Contou, Damien, additional, Roux, Damien, additional, Ricard, Jean-Damien, additional, Federici, Laura, additional, Zucman, Noémie, additional, Freita Ramos, Santiago, additional, Amouretti, Marc, additional, Besset, Sébastien, additional, Gernez, Coralie, additional, Delbove, Agathe, additional, Voiriot, Guillaume, additional, Elabbadi, Alexandre, additional, Fartoukh, Muriel, additional, Préau, Sébastien, additional, Favory, Raphaël, additional, Pierre, Alexandre, additional, Sement, Arnaud, additional, Terzi, Nicolas, additional, Sigaud, Florian, additional, Candille, Clara, additional, Turbil, Emanuele, additional, Maizel, Julien, additional, Brault, Clément, additional, Zerbib, Yoan, additional, Joret, Aurélie, additional, Daubin, Cédric, additional, Lefebvre, Laurent, additional, Giraud, Alais, additional, Auvet, Adrien, additional, Vinsonneau, Christophe, additional, Marzouk, Mehdi, additional, Quenot, Jean-Pierre, additional, Andreu, Pascal, additional, Labruyère, Marie, additional, Roudaut, Jean-Baptiste, additional, Aptel, François, additional, Boyer, Alexandre, additional, Boyer, Philippe, additional, Lacherade, Jean-Claude, additional, Hille, Hugo, additional, Bouteloup, Marie, additional, Jeannot, Matthieu, additional, Feller, Marc, additional, Grillet, Guillaume, additional, Levy, Bruno, additional, and Kimmoun, Antoine, additional

Published
2021
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7. Etomidate increases susceptibility to pneumonia in trauma patients

Author

Asehnoune, Karim, Mahe, Pierre Joachim, Seguin, Philippe, Jaber, Samir, Jung, Boris, Guitton, Christophe, Chatel-Josse, Nolwen, Subileau, Aurelie, Tellier, Anne Charlotte, Masson, Françoise, Renard, Benoit, Malledant, Yannick, Lejus, Corinne, Volteau, Christelle, Sébille, Véronique, and Roquilly, Antoine

Published
2012
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8. Massage therapy reduces arterial puncture-induced pain: the randomized cross-over bi-center TORREA study

Author

Lasocki, Sigismond, Moncho, Régine, Bontemps, Julien, Verger, Xavier, Tellier, Anne-Charlotte, Gergaud, Soizic, and Ferrandière, Martine

Subjects
Blood -- Medical examination, Massage, Health care industry
Abstract

Author(s): Sigismond Lasocki [sup.1], Régine Moncho [sup.1], Julien Bontemps [sup.2], Xavier Verger [sup.1], Anne-Charlotte Tellier [sup.2], Soizic Gergaud [sup.1], Martine Ferrandière [sup.2] Author Affiliations: (1) grid.411147.6, 0000 0004 0472 0283, [...]

Published
2020
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10. Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS

Author

Jabaudon, Matthieu, primary, Audard, Jules, additional, Pereira, Bruno, additional, Jaber, Samir, additional, Lefrant, Jean-Yves, additional, Blondonnet, Raiko, additional, Godet, Thomas, additional, Futier, Emmanuel, additional, Lambert, Céline, additional, Bazin, Jean-Etienne, additional, Bastarache, Julie A., additional, Constantin, Jean-Michel, additional, Ware, Lorraine B., additional, Souweine, Bertrand, additional, Eisenmann, Nathanael, additional, Quenot, Jean-Pierre, additional, Seguin, Philippe, additional, Asehnoune, Karim, additional, Lasocki, Sigismond, additional, Ferrandiere, Martine, additional, Sossou, Achile, additional, Langeron, Olivier, additional, Leone, Marc, additional, Dupont, Herve, additional, Veber, Benoit, additional, Ichai, Carole, additional, Rimmelé, Thomas, additional, Legay, François, additional, Grelon, Fabien, additional, Dahyot-Fizelier, Claire, additional, Cayot, Sophie, additional, Guerin, Renaud, additional, Verlhac, Camille, additional, Chabanne, Russell, additional, Cosserant, Bernard, additional, Lautrette, Alexandre, additional, Muller, Laurent, additional, Massanet, Pablo, additional, Boutin, Caroline, additional, Barbar, Saber, additional, Roger, Claire, additional, Belafia, Fouad, additional, Cisse, Moussa, additional, Monnin, Marion, additional, Conseil, Matthieu, additional, Carr, Julie, additional, De Jong, Audrey, additional, Chanques, Gérald, additional, Dargent, Auguste, additional, Crozon, Thomas, additional, Clauzel, Julien, additional, Le Core, Marinne, additional, Andreu, Pascal, additional, Lebouvrier, Thomas, additional, Launey, Yoann, additional, Roquilly, Antoine, additional, Cinotti, Raphael, additional, Tellier, Anne-Charlotte, additional, Barbaz, Mathilde, additional, Cohen, Benjamin, additional, Lemarche, Edouard, additional, Bertrand, Pierre-Marie, additional, Arbelot, Charlotte, additional, Zieleskiewicz, Laurent, additional, Hammad, Emmanuelle, additional, Duclos, Garry, additional, Calypso, Mathieu, additional, Orban, Jean-Christophe, additional, Quintard, Hervé, additional, Assefi, Mona, additional, Morel, Jerome, additional, Molliex, Serge, additional, Petitas, Frank, additional, and Nanadougmar, Hadanou, additional

Published
2020
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11. Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial

Author

Jean-Michel Constantin, Matthieu Jabaudon, Jean-Yves Lefrant, Samir Jaber, Jean-Pierre Quenot, Olivier Langeron, Martine Ferrandière, Fabien Grelon, Philippe Seguin, Carole Ichai, Benoit Veber, Bertrand Souweine, Thomas Uberti, Sigismond Lasocki, François Legay, Marc Leone, Nathanael Eisenmann, Claire Dahyot-Fizelier, Hervé Dupont, Karim Asehnoune, Achille Sossou, Gérald Chanques, Laurent Muller, Jean-Etienne Bazin, Antoine Monsel, Lucile Borao, Jean-Marc Garcier, Jean-Jacques Rouby, Bruno Pereira, Emmanuel Futier, Cayot Sophie, Godet Thomas, Guerin Renaud, Verlac Camille, Chabanne Russel, Cosserant Bernard, Blondonnet Raiko, Lautrette Alexandre, Eisenmann Nathanael, Muller Laurent, Massanet Pablo, Boutin Caroline, Barbar Saber, Roger Claire, Belafia Fouad, Cisse Moussa, Monnin Marion, Conseil Matthieu, Carr Julie, De Jong Audrey, Dargent Auguste, Andreu Pascal, Lebouvrier Thomas, Launey Yoann, Roquilly Antoine, Cinotti Raphael, Tellier Anne-Charlotte, Barbaz Mathilde, Cohen Benjamin, Lemarche Edouard, Bertrand Pierre-Marie, Arberlot Charlotte, Zieleskiewicz Laurent, Hammad Emmanuelle, Duclos Garry, Mathie Calypso, Dupont Herve, Veber Benoit, Orban Jean-Christophe, Quintard Hervé, Rimmele Thomas, Crozon-Clauzel Julien, Le Core Marinne, Grelon Fabien, Assefi Mona, Petitas Frank, Morel Jerome, Molliex Serge, Hadanou Nanadougmar, CHU Clermont-Ferrand, Service d'Anésthésie Réanimation [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Réanimation Médicale (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Le Mans (CH Le Mans), CHU Pontchaillou [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de réanimation, Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital St Roch, Département d'anesthésie-Réanimation-Samu, CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Unité de soins intensifs [Clermont Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], Edouard Herriot Hospital, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), CHU de Saint-Brieuc, Service Anesthésie et Réanimation [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Thérapeutiques cliniques et expérimentales des infections (EA 3826) (EA 3826), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Department of Anesthesiology and Critical Care Medicine, Emile-Roux general hospital, Le Puy-en-Velay, Université de Montpellier (UM), Immunologie - Immunopathologie - Immunothérapie (I3), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Génétique, Reproduction et Développement (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Department of Perioperative Medicine, CHU Clermont-Ferrand, CHU Pitié-Salpêtrière [APHP], Hopital Général, Le Mans, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Clermont-Ferrand-Hôpital Gabriel Montpied, Hospital General Saint-Brieuc, Hôpital Nord [CHU - APHM]-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU), Centre Régional de Lutte Contre le Cancer Jean Perrin, Centre hospitalier universitaire d'Amiens (CHU Amiens-Picardie), Service de réanimation adulte, département d'anesthésie-réanimation, CHU Clermont-Ferrand-Hôtel Dieu, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), University Hospital of Clermont-Ferrand, Institut Pascal - Clermont Auvergne (IP), Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Unité de biostatistiques, CHU Clermont-Ferrand-Hôpital Montpied, Génétique, Reproduction et Développement - Clermont Auvergne (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), MORNET, Dominique, Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, ARDS, medicine.medical_treatment, [SDV]Life Sciences [q-bio], law.invention, Positive-Pressure Respiration, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Fraction of inspired oxygen, Intensive care, medicine, Prone Position, Tidal Volume, Humans, Single-Blind Method, 030212 general & internal medicine, Prospective Studies, Precision Medicine, Lung, Positive end-expiratory pressure, Tidal volume, ComputingMilieux_MISCELLANEOUS, Proportional Hazards Models, Mechanical ventilation, Respiratory Distress Syndrome, business.industry, Hazard ratio, Middle Aged, medicine.disease, Respiration, Artificial, 3. Good health, [SDV] Life Sciences [q-bio], Intensive Care Units, Editorial Commentary, Treatment Outcome, 030228 respiratory system, Female, France, business
Abstract

The effect of personalised mechanical ventilation on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remains uncertain and needs to be evaluated. We aimed to test whether a mechanical ventilation strategy that was personalised to individual patients' lung morphology would improve the survival of patients with ARDS when compared with standard of care.We designed a multicentre, single-blind, stratified, parallel-group, randomised controlled trial enrolling patients with moderate-to-severe ARDS in 20 university or non-university intensive care units in France. Patients older than 18 years with early ARDS for less than 12 h were randomly assigned (1:1) to either the control group or the personalised group using a minimisation algorithm and stratified according to the study site, lung morphology, and duration of mechanical ventilation. Only the patients were masked to allocation. In the control group, patients received a tidal volume of 6 mL/kg per predicted bodyweight and positive end-expiratory pressure (PEEP) was selected according to a low PEEP and fraction of inspired oxygen table, and early prone position was encouraged. In the personalised group, the treatment approach was based on lung morphology; patients with focal ARDS received a tidal volume of 8 mL/kg, low PEEP, and prone position. Patients with non-focal ARDS received a tidal volume of 6 mL/kg, along with recruitment manoeuvres and high PEEP. The primary outcome was 90-day mortality as established by intention-to-treat analysis. This study is registered online with ClinicalTrials.gov, NCT02149589.From June 12, 2014, to Feb 2, 2017, 420 patients were randomly assigned to treatment. 11 patients were excluded in the personalised group and nine patients were excluded in the control group; 196 patients in the personalised group and 204 in the control group were included in the analysis. In a multivariate analysis, there was no difference in 90-day mortality between the group treated with personalised ventilation and the control group in the intention-to-treat analysis (hazard ratio [HR] 1·01; 95% CI 0·61-1·66; p=0·98). However, misclassification of patients as having focal or non-focal ARDS by the investigators was observed in 85 (21%) of 400 patients. We found a significant interaction between misclassification and randomised group allocation with respect to the primary outcome (p0·001). In the subgroup analysis, the 90-day mortality of the misclassified patients was higher in the personalised group (26 [65%] of 40 patients) than in the control group (18 [32%] of 57 patients; HR 2·8; 95% CI 1·5-5·1; p=0·012.Personalisation of mechanical ventilation did not decrease mortality in patients with ARDS, possibly because of the misclassification of 21% of patients. A ventilator strategy misaligned with lung morphology substantially increases mortality. Whether improvement in ARDS phenotyping can decrease mortality should be assessed in a future clinical trial.French Ministry of Health (Programme Hospitalier de Recherche Clinique InterRégional 2013).

Published
2019
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12. Recipient Selection for Optimal Utilization of Discarded Grafts in Liver Transplantation

Author

Giretti, Giovanni, primary, Barbier, Louise, additional, Bucur, Petru, additional, Marques, Frédéric, additional, Perarnau, Jean-Marc, additional, Ferrandière, Martine, additional, Tellier, Anne-Charlotte, additional, Kerouredan, Vincent, additional, Altieri, Mario, additional, Causse, Xavier, additional, Debette-Gratien, Maryline, additional, Silvain, Christine, additional, and Salamé, Ephrem, additional

Published
2018
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13. Epidemiological Outbreaks of Pneumocystis jirovecii Pneumonia Are Not Limited to Kidney Transplant Recipients: Genotyping Confirms Common Source of Transmission in a Liver Transplantation Unit

Author

Desoubeaux, Guillaume, primary, Dominique, Manon, additional, Morio, Florent, additional, Thepault, Rose-Anne, additional, Franck-Martel, Claire, additional, Tellier, Anne-Charlotte, additional, Ferrandière, Martine, additional, Hennequin, Christophe, additional, Bernard, Louis, additional, Salamé, Ephrem, additional, Bailly, Éric, additional, and Chandenier, Jacques, additional

Published
2016
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14. Sensibilité aux échinocandines des souches de C. glabrata isolées en réanimation chirurgicale au CHU de Tours (nov 2013–avril 2014) : étude phénotypique et génotypique

Author

Defresne, Thibault, primary, Bailly, Éric, additional, Morio, Florent, additional, Tellier, Anne-Charlotte, additional, Provot, Stéphanie, additional, Ferrandiere, Martine, additional, Lagarrigue, François, additional, Vourc’H, Patrick, additional, Chandenier, Jacques, additional, and Desoubeaux, Guillaume, additional

Published
2015
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17. Epidemiological Outbreaks of Pneumocystis jiroveciiPneumonia Are Not Limited to Kidney Transplant Recipients: Genotyping Confirms Common Source of Transmission in a Liver Transplantation Unit

Author

Desoubeaux, Guillaume, Dominique, Manon, Morio, Florent, Thepault, Rose-Anne, Franck-Martel, Claire, Tellier, Anne-Charlotte, Ferrandière, Martine, Hennequin, Christophe, Bernard, Louis, Salamé, Ephrem, Bailly, Éric, and Chandenier, Jacques

Abstract

ABSTRACTOver a 5-month period, four liver transplant patients at a single hospital were diagnosed with Pneumocystis jiroveciipneumonia (PCP). This unusually high incidence was investigated using molecular genotyping. Bronchoalveolar lavage fluids (BALF) obtained from the four liver recipients diagnosed with PCP were processed for multilocus sequence typing (MLST) at three loci (SOD, mt26s, and CYB). Twenty-four other BALF samples, which were positive for P. jiroveciiand collected from 24 epidemiologically unrelated patients with clinical signs of PCP, were studied in parallel by use of the same method. Pneumocystis jiroveciiisolates from the four liver recipients all had the same genotype, which was different from those of the isolates from all the epidemiologically unrelated individuals studied. These findings supported the hypothesis of a common source of contamination or even cross-transmission of a single P. jiroveciiclone between the four liver recipients. Hospitalization mapping showed several possible encounters between these four patients, including outpatient consultations on one particular date when they all possibly met. This study demonstrates the value of molecular genotyping of P. jiroveciiisolated from clinical samples for epidemiological investigation of PCP outbreaks. It is also the first description of a common source of exposure to a single P. jiroveciiclone between liver transplant recipients and highlights the importance of prophylaxis in such a population.

Published
2016
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