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26 results on '"Teng, Fangfang"'

7. Supplemental Figures S1-S5 from Comparative microstructural study on the teeth of Mesozoic birds and non-avian dinosaurs

Author

Wang, Yan, Li, Zhiheng, Wang, Chun-Chieh, Bailleul, Alida M., Wang, Min, O'Connor, Jingmai, Li, Jinhua, Zheng, Xiaoting, Pei, Rui, Teng, Fangfang, Wang, Xiaoli, and Zhou, Zhonghe

Abstract

Although it is commonly considered that in birds, there is a trend towards reduced dentition, teeth persisted in birds for 90 Ma and numerous macroscopic morphologies are observed. However, the extent to which the microstructure of bird teeth differs from other lineages is poorly understood. To explore the microstructural differences of the teeth of birds in comparison to closely related non-avialan dinosaurs, the enamel and dentine-related features were evaluated in four Mesozoic paravian species from the Yanliao and Jehol biotas. Different patterns of dentinal tubular tissues with mineralized extensions of the odontoblast processes were revealed through the examination of histological sectioning under electron microscopy. Secondary modification of the tubular structures, forming reactive sclerotic dentin of Longipteryx, and the mineralization of peritubular dentin of Sapeornis were observed in the mantle dentin region. The new observed features combined with other dentinal-associated ultrastructure suggest that the developmental mechanisms controlling dentin formation are quite plastic, permitting the evolution of unique morphologies associated with specialized feeding behaviours in the toothed birds. Proportionally greater functional stress placed on the stem bird teeth may have induced reactive dentin mineralization, which was observed more often within tubules of these taxa, suggests modifications to the dentin to counteract potential failure.

Published
2023
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15. Xinghaiornis lini(Aves: Ornithothoraces) from the Early Cretaceous of Liaoning: An Example of Evolutionary Mosaic in Early Birds

Author

Wang Xuri, Teng Fangfang, Chiappe M. Luis, and Ji Qiang

Subjects
Xinghaiornis, biology, Ecology, Rostrum, Geology, Ornithothoraces, biology.organism_classification, Yixian Formation, Mosaic, Cretaceous, Trophic level
Abstract

We describe a new species of Early Cretaceous bird from the Yixian Formation of Liaoning Province. Xinghaiornis lini gen. et sp. nov. is relatively large and characterized by a long, toothless rostrum and an elevated pedal digit I. The design of the skull and feet suggests that this bird was likely a mud-prober. This discovery provides strong support indicating that this avian trophic specialization originated at least 125 million years ago.

Published
2013

24. Methoxy poly (ethylene glycol)-b-poly (δ-valerolactone) copolymeric micelles for improved skin delivery of ketoconazole.

Author

Deng, Peizong, Teng, Fangfang, Zhou, Feilong, Song, Zhimei, Meng, Ning, and Feng, Runliang

Subjects
*KETOCONAZOLE, *MYCOSES, *MICELLES, *X-ray diffraction, *FLUORESCENCE microscopy
Abstract

Ketoconazole is a broad spectrum imidazole antifungal drug. For the treatment of superficial fungal infections with ketoconazole, it needs to be permeated to deep skin layers. In order to develop topical formulation of ketoconazole for improving its skin deposition and water-solubility, ketoconazole-loaded methoxy poly (ethylene glycol)-b-poly (δ-valerolactone) micelles were developed through thin-film hydration method. Particle size, drug loading capacity, infrared spectrum and X-ray diffraction of drug-loaded micelles were characterized. The optimal drug formulation was selected for skin delivery and deposition investigation performed by use of mice skin, and itsin vitrorelease and antifungal activity were also investigated. Penetration and distribution in the skin were also visualized using fluorescein-loaded micelles and fluorescence microscopy. The drug-loaded micelles were obtained with encapsulation efficiency of 86.39% and particle diameter of about 12 nm. The micelles made ketoconazole aqueous solubility increase to 86-fold higher than crude one. Ketoconazole-loaded micelles showed no skin permeation of ketoconazole, obviously enhance skin deposition and demonstrated similar antifungal activity as compared with marketed ketoconazole cream. Fluorescein-loaded micelles displayed higher skin deposition than fluorescein water solution. These results demonstrate that the MPEG-PVL micelle is a potential delivery system for ketoconazole in the field of skin delivery. [ABSTRACT FROM AUTHOR]

Published
2017
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26. Recent Progress of Nano-drug Delivery System for Liver Cancer Treatment

Author

Zhou, Feilong, Teng, Fangfang, Deng, Peizong, Meng, Ning, Song, Zhimei, and Feng, Runliang

Abstract

Liver cancer is one of serious diseases which threaten human life and health. Studies on the treatment of liver cancer have attracted widespread attention. Application of nano-drug delivery system (NDDS) can not only improve selective drug delivery to liver tissue and improve the bioavailability of drug, but also can reduce the side effects of drugs when it is specially modified in the respects of structure modification or specific target molecules decoration. This review will address the latest development of liver-targeted drug delivery system.

Published
2017
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