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4 results on '"Teng Kiat Koh"'

1. A poor perspective of self weight significantly increases adverse outcomes in non-alcoholic fatty liver disease (NAFLD)

Author

Clarissa Elysia Fu, Cheng Han Ng, Nicholas W. S. Chew, Zane En Qi Heng, Yip Han Chin, Jingxuan Quek, Wen Hui Lim, Jieling Xiao, Kai En Chan, Darren Jun Hao Tan, Caitlyn Tan, Sitong Zhang, Teng Kiat Koh, Benjamin Nah, Yock Young Dan, Nicholas Syn, Mohammad Shadab Siddiqui, Arun J. Sanyal, Mazen Noureddin, and Mark Muthiah

Subjects
weight perception, NAFLD, non-alcoholic fatty liver disease, NAFLD outcomes, mortality, Medicine (General), R5-920
Abstract

BackgroundNon-alcoholic fatty liver disease (NAFLD) is prevalent amongst overweight and obese individuals, and weight loss remains the main mode of treatment for NAFLD patients. Weight perception plays a key role in the efficacy of such treatment. The current study aims to investigate the prevalence, associating factors and implications of poor weight perception amongst such individuals.MethodsAn analysis was done on data collected from NHANES between 1999 and 2018. Comparison was made between NAFLD individuals with and without poor weight perception in terms of prevalence, associated characteristics, and clinical outcomes. Multivariate analysis was used to compare effect size of adverse events associated with NAFLD individuals with poor weight perception.ResultsOf the 12,170 NAFLD patients, 19.2% (CI: 18.5 to 19.9%) had poor weight perception. Poor weight perception was significantly associated with lower education levels, reduced levels of exercise and unhealthier lipid profiles. There was an increased risk in all-cause mortality (HR: 1.18, CI: 1.00 to 1.38, p = 0.047), cardiovascular disease mortality (SHR: 1.33, CI: 1.03 to 1.71, p = 0.026), major adverse cardiovascular events (OR: 1.21 CI: 1.10 to 1.32, p < 0.001), and advanced fibrosis (OR: 1.30, CI: 1.03 to 1.64, p = 0.025) for individuals with poor weight perception.ConclusionThis study highlights the positive association between appropriate weight perception and better outcomes in individuals with NAFLD. Poor weight perception increased the risk of adverse events and decreased inclination toward seeking weight loss treatment. Greater emphasis should be placed on dealing with weight perception in individuals with NAFLD for better treatment outcomes.

Published
2022
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2. DEXA Scan Body Fat Mass Distribution in Obese and Non-Obese Individuals and Risk of NAFLD-Analysis of 10,865 Individuals

Author

Caitlyn Tan, Kai En Chan, Cheng Han Ng, Michael Tseng, Nicholas Syn, Ansel Shao Pin Tang, Yip Han Chin, Wen Hui Lim, Darren Jun Hao Tan, Nicholas Chew, Elden Yen Hng Ong, Teng Kiat Koh, Jieling Xiao, Douglas Chee, Arun Valsan, Mohammad Shadab Siddiqui, Daniel Huang, Mazen Noureddin, Karn Wijarnpreecha, and Mark D. Muthiah

Subjects
General Medicine, non-alcoholic fatty liver disease, non-obese NAFLD, lean NAFLD, dual-energy X-ray absorptiometry, obesity
Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide yet predicting non-obese NAFLD is challenging. Thus, this study investigates the potential of regional fat percentages obtained by dual-energy X-ray absorptiometry (DXA) in accurately assessing NAFLD risk. Using the United States National Health and Nutrition Examination Survey (NHANES) 2011–2018, multivariate logistic regression and marginal analysis were conducted according to quartiles of regional fat percentages, stratified by gender. A total of 23,752 individuals were analysed. Males generally showed a larger increase in marginal probabilities of NAFLD development than females, except in head fat, which had the highest predictive probabilities of non-obese NAFLD in females (13.81%, 95%CI: 10.82–16.79) but the lowest in males (21.89%, 95%CI: 20.12–23.60). Increased percent of trunk fat was the strongest predictor of both non-obese (OR: 46.61, 95%CI: 33.55–64.76, p < 0.001) and obese NAFLD (OR: 2.93, 95%CI: 2.07–4.15, p < 0.001), whereas raised percent gynoid and leg fat were the weakest predictors. Ectopic fat deposits are increased in patients with non-obese NAFLD, with greater increases in truncal fat over gynoid fat. As increased fat deposits in all body regions can increase odds of NAFLD, therapeutic intervention to decrease ectopic fat, particularly truncal fat, may decrease NAFLD risk.

Published
2022

4. Coronary and arch hybrid surgery in a patient with infrarenal aortic occlusion

Author

Kristine L K Teoh, Jocelyn Zi Lin Ting, Bernard Wee, Vitaly Sorokin, Julian Wong, Teng Kiat Koh, and Rustem Khamitov

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Computed Tomography Angiography, medicine.medical_treatment, Aortic Diseases, Arterial Occlusive Diseases, Constriction, Pathologic, Coronary Artery Disease, 030204 cardiovascular system & hematology, Aortography, law.invention, Blood Vessel Prosthesis Implantation, 03 medical and health sciences, Aortic aneurysm, 0302 clinical medicine, law, medicine.artery, Occlusion, medicine, Cardiopulmonary bypass, Humans, Aorta, Abdominal, cardiovascular diseases, Coronary Artery Bypass, Arch, Aged, Aorta, Ejection fraction, Aortic Aneurysm, Thoracic, business.industry, Endovascular Procedures, Stent, General Medicine, medicine.disease, Sternotomy, Blood Vessel Prosthesis, Surgery, Treatment Outcome, 030228 respiratory system, cardiovascular system, Stents, medicine.symptom, Cardiology and Cardiovascular Medicine, Claudication, business
Abstract

A 65-year-old gentleman with claudication underwent contrast-enhanced computed tomography. The scan showed occlusion of the infrarenal abdominal aorta and a 6.0 × 3.7 cm saccular zone-3 arch aneurysm. The left ventricular ejection fraction was 35% and a coronary angiogram revealed triple-vessel disease. In view of the patient’s high risk with EuroSCORE II 20.34%, coronary artery surgery was combined with hybrid type I arch aneurysm repair. An endovascular stent was delivered in an antegrade manner. Open heart surgery and a hybrid type I arch intervention can be performed simultaneously through a midline sternotomy approach.

Published
2018
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