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5. Association of LDL-cholesterol <1.8 mmol/L and statin use with the recurrence of intracerebral hemorrhage

Author

LEE, Tsz Ching, primary, Leung, William CY, additional, Ho, Chun, additional, Chiu, Megan WL, additional, Leung, Ian YH, additional, Wong, Yuen Kwun, additional, Liu, Roxanna K.C., additional, Sum, Christopher HF, additional, Lui, David TW, additional, Cheung, Raymond, additional, Leung, Gilberto Ka Kit, additional, Chan, Koon Ho, additional, Teo, Kay-Cheong, additional, and Lau, G K K, additional

Published
2024
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6. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Harkness, Kirsty, Shaw, Louise, Sword, Jane, Mohd Nor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Birns, Jonathan, Cohen, David, Sekaran, Lakshmanan, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, Sprigg, Nikola, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil, Shakeshaft, Clare, Brown, Martin, Charidimou, Andreas, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark, Yousry, Tarek, Flossmann, Enrico, Muir, Keith, Gratz, Pascal, Mattle, Heinrich, Panos, Leonidas, Korczyn, Amos, Kliper, Efrat, Maeder, Philippe, Gass, Achim, Pachai, Chahin, Bracoub, Luc, Douste-Blazy, Marie-Yvonne, Fratacci, Marie Dominique, Vicaut, Eric, Sato, Shoichiro, Miwa, Kaori, Fujita, Kyohei, Ide, Toshihiro, Ma, Henry, Ly, John, Singhal, Shaloo, Chandra, Ronil, Slater, Lee-Anne, Soufan, Cathy, Moran, Christopher, Traenka, Christopher, Thilemann, Sebastian, Fladt, Joachim, Gensicke, Henrik, Bonati, Leo, Kim, Beom Joon, Han, Moon-Ku, Kang, Jihoon, Ko, Eunbin, Yang, Mi Hwa, Jang, Myung Suk, Murphy, Sean, Carty, Fiona, Akijian, Layan, Thornton, John, Schembri, Mark, Douven, Elles, Delgado-Mederos, Raquel, Marín, Rebeca, Camps-Renom, Pol, Guisado-Alonso, Daniel, Nuñez, Fidel, Medrano-Martorell, Santiago, Merino, Elisa, Iida, Kotaro, Ikeda, Syuhei, Irie, Hiroyuki, Demirelli, Derya Selcuk, Medanta, Jayesh Modi, Zerna, Charlotte, Hernández, Maria Valdés, Armitage, Paul, Heye, Anna, Muñoz-Maniega, Susana, Sakka, Eleni, Thrippleton, Michael, Dennis, Martin, Beigneux, Ysoline, Silva, Mauro, Venketasubramanian, Narayanaswamy, Ho, Shu Leung, Cheung, Raymond Tak Fai, Chan, Koon Ho, Teo, Kay Cheong, Hui, Edward, Kwan, Joseph Shiu Kwong, Chang, Richard, Tse, Man Yu, Hoi, Chu Peng, Chan, Chung Yan, Chan, Oi Ling, Cheung, Ryan Hoi Kit, Wong, Edmund Ka Ming, Leung, Kam Tat, Tsang, Suk Fung, Ip, Hing Lung, Ma, Sze Ho, Ma, Karen, Fong, Wing Chi, Li, Siu Hung, Li, Richard, Ng, Ping Wing, Wong, Kwok Kui, Liu, Wenyan, Wong, Lawrence, Ramos, Lino, De Schryver, Els, Jöbsis, Joost, van der Sande, Jaap, Brouwers, Paul, Roos, Yvo, Stam, Jan, Bakker, Stef, Verbiest, Henk, Schoonewille, Wouter, Linn, Cisca, Hertzberger, Leopold, van Gemert, Maarten, Berntsen, Paul, Van Dam-Nolen, Dianne, Kooi, M Eline, Van der Lugt, Aad, Koudstaal, Peter, Leff, Alexander, Ward, Nicholas, Nachev, Parashkev, Perry, Richard, Ozkan, Hatice, Mitchell, John, Best, Jonathan G, Ambler, Gareth, Wilson, Duncan, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sanchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M, Ben Assayag, Einor, Hallevi, Hen, Molad, Jeremy, Nishihara, Masashi, Tanaka, Jun, Coutts, Shelagh B, Polymeris, Alexandros, Wagner, Benjamin, Seiffge, David J, Lyrer, Philippe, Algra, Ale, Kappelle, L Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R, Lip, Gregory Y H, Fischer, Urs, El-Koussy, Marwan, Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J, Mess, Werner H, Nederkoorn, Paul J, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M, Maaijwee, Noortje, Guevarra, Anne Cristine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Régis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, Hendrikse, Jeroen, Kelly, Peter J, Wardlaw, Joanna, Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Engelter, Stefan T, Peters, Nils, Smith, Eric E, Hara, Hideo, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M, Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, and Werring, David J

Published
2021
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7. Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA:A Pooled Analysis

Author

Best, Jonathan G., Ambler, Gareth, Wilson, Duncan, Du, Houwei, Lee, Keon Joo, Lim, Jae Sung, Teo, Kay Cheong, Mak, Henry, Kim, Young Dae, Song, Tae Jin, Selcuk Demirelli, Derya, Nishihara, Masashi, Yoshikawa, Masaaki, Kubacka, Marta, Zietz, Annaelle, Al-Shahi Salman, Rustam, Jäger, Hans Rolf, Lip, Gregory Y.H., Panos, Leonidas, Goeldlin, Martina B., Slater, Lee Anne, Karayiannis, Christopher Charles, Phan, Thanh G., Bellut, Maximilian, Abrigo, Jill, Cheng, Cyrus, Leung, Thomas W., Chu, Winnie, Chappell, Francesca, Makin, Stephen D.J., Van Dam-Nolen, Dianne H.K., Kooi, M. Eline, Köhler, Sebastian, Staals, Julie, Kuchcinski, Grégory, Bordet, Régis, Dubost, Florian, Wardlaw, Joanna M., Soo, Yannie O.Y., Fluri, Felix, Srikanth, Velandai K., Jung, Simon, Peters, Nils, Hara, Hideo, Yakushiji, Yusuke, Necioglu Orken, Dilek, Heo, Ji Hoe, Lau, Gary Kui Kai, Bae, Hee Joon, Werring, David J., Best, Jonathan G., Ambler, Gareth, Wilson, Duncan, Du, Houwei, Lee, Keon Joo, Lim, Jae Sung, Teo, Kay Cheong, Mak, Henry, Kim, Young Dae, Song, Tae Jin, Selcuk Demirelli, Derya, Nishihara, Masashi, Yoshikawa, Masaaki, Kubacka, Marta, Zietz, Annaelle, Al-Shahi Salman, Rustam, Jäger, Hans Rolf, Lip, Gregory Y.H., Panos, Leonidas, Goeldlin, Martina B., Slater, Lee Anne, Karayiannis, Christopher Charles, Phan, Thanh G., Bellut, Maximilian, Abrigo, Jill, Cheng, Cyrus, Leung, Thomas W., Chu, Winnie, Chappell, Francesca, Makin, Stephen D.J., Van Dam-Nolen, Dianne H.K., Kooi, M. Eline, Köhler, Sebastian, Staals, Julie, Kuchcinski, Grégory, Bordet, Régis, Dubost, Florian, Wardlaw, Joanna M., Soo, Yannie O.Y., Fluri, Felix, Srikanth, Velandai K., Jung, Simon, Peters, Nils, Hara, Hideo, Yakushiji, Yusuke, Necioglu Orken, Dilek, Heo, Ji Hoe, Lau, Gary Kui Kai, Bae, Hee Joon, and Werring, David J.

Abstract

Background and Objectives: Visible perivascular spaces are an MRI marker of cerebral small vessel disease and might predict future stroke. However, results from existing studies vary. We aimed to clarify this through a large collaborative multicenter analysis. Methods: We pooled individual patient data from a consortium of prospective cohort studies. Participants had recent ischemic stroke or transient ischemic attack (TIA), underwent baseline MRI, and were followed up for ischemic stroke and symptomatic intracranial hemorrhage (ICH). Perivascular spaces in the basal ganglia (BGPVS) and perivascular spaces in the centrum semiovale (CSOPVS) were rated locally using a validated visual scale. We investigated clinical and radiologic associations cross-sectionally using multinomial logistic regression and prospective associations with ischemic stroke and ICH using Cox regression. Results: We included 7,778 participants (mean age 70.6 years; 42.7% female) from 16 studies, followed up for a median of 1.44 years. Eighty ICH and 424 ischemic strokes occurred. BGPVS were associated with increasing age, hypertension, previous ischemic stroke, previous ICH, lacunes, cerebral microbleeds, and white matter hyperintensities. CSOPVS showed consistently weaker associations. Prospectively, after adjusting for potential confounders including cerebral microbleeds, increasing BGPVS burden was independently associated with future ischemic stroke (versus 0-10 BGPVS, 11-20 BGPVS: HR 1.19, 95% CI 0.93-1.53; 21+ BGPVS: HR 1.50, 95% CI 1.10-2.06; p = 0.040). Higher BGPVS burden was associated with increased ICH risk in univariable analysis, but not in adjusted analyses. CSOPVS were not significantly associated with either outcome. Discussion: In patients with ischemic stroke or TIA, increasing BGPVS burden is associated with more severe cerebral small vessel disease and higher ischemic stroke risk. Neither BGPVS nor CSOPVS were independently associated with future ICH.

Published
2024

8. Risk of Seizure Aggravation after COVID-19 Vaccinations in Patients with Epilepsy.

Author

Leung, William C.Y., Ho, Ryan Wui-Hang, Leung, Anthony Ka-Long, Chu, Florinda Hui-Ning, Lo, Cheuk Nam Rachel, Chan, Andrian A., Chan, Cheuk Yan Claudia, Chan, Desmond Yin Hei, Chui, Jacklyn Hoi Ying, Li, Wai Tak Victor, Yeung, Elton Hau Lam, Teo, Kay Cheong, Lau, Gary Kui-Kai, and Chang, Richard Shek-Kwan

Subjects
COVID-19, COVID-19 vaccines, PEOPLE with epilepsy, SEIZURES (Medicine), ANTICONVULSANTS
Abstract

Although Coronavirus disease 2019 (COVID-19) vaccinations are generally recommended for persons with epilepsy (PwE), a significant vaccination gap remains due to patient concerns over the risk of post-vaccination seizure aggravation (PVSA). In this single-centre, retrospective cohort study, we aimed to determine the early (7-day) and delayed (30-day) risk of PVSA, and to identify clinical predictors of PVSA among PwE. Adult epilepsy patients aged ≥18 years without a history of COVID-19 infection were recruited from a specialty epilepsy clinic in early 2022. Demographic, epilepsy characteristics, and vaccination data were extracted from a centralized electronic patient record. Seizure frequency before and after vaccination, vaccination-related adverse effects, and reasons for or against vaccination were obtained by a structured questionnaire. A total of 786 PwEs were included, of which 27.0% were drug-resistant. At the time of recruitment, 74.6% had at least 1 dose of the COVID-19 vaccine. Subjects with higher seizure frequency (p < 0.0005), on more anti-seizure medications (p = 0.004), or had drug-resistant epilepsy (p = 0.001) were less likely to be vaccinated. No significant increase in seizure frequency was observed in the early (7 days) and delayed phases (30 days) after vaccination in our cohort. On the contrary, there was an overall significant reduction in seizure frequency 30 days after vaccination (1.31 vs. 1.89, t = 3.436; p = 0.001). This difference was seen in both types of vaccine (BNT162b2 and CoronaVac) and drug-resistant epilepsy, but just missed significance for the second dose (1.13 vs. 1.87, t = 1.921; p = 0.055). Only 5.3% had PVSA after either dose of vaccine. Higher pre-vaccination seizure frequency of ≥1 per week (OR 3.01, 95% CI 1.05–8.62; p = 0.04) and drug-resistant status (OR 3.32, 95% CI 1.45–249 7.61; p = 0.005) were predictive of PVSA. Meanwhile, seizure freedom for 3 months before vaccination was independently associated with a lower risk of PVSA (OR 0.11, 95% CI 0.04–0.28; p < 0.0005). This may guide epilepsy treatment strategies to achieve better seizure control for at least 3 months prior to vaccination. As COVID-19 shifts to an endemic phase, this study provides important data demonstrating the overall safety of COVID-19 vaccinations among PwE. Identification of high-risk patients with subsequent individualized approaches in treatment and monitoring strategies may alleviate vaccination hesitancy among PwE. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA

Author

Best, Jonathan G., primary, Ambler, Gareth, additional, Wilson, Duncan, additional, Du, Houwei, additional, Lee, Keon-Joo, additional, Lim, Jae-Sung, additional, Teo, Kay Cheong, additional, Mak, Henry, additional, Kim, Young Dae, additional, Song, Tae-Jin, additional, Selcuk Demirelli, Derya, additional, Nishihara, Masashi, additional, Yoshikawa, Masaaki, additional, Kubacka, Marta, additional, Zietz, Annaelle, additional, Al-Shahi Salman, Rustam, additional, Jäger, Hans Rolf, additional, Lip, Gregory Y.H., additional, Panos, Leonidas, additional, Goeldlin, Martina B., additional, Slater, Lee-Anne, additional, Karayiannis, Christopher Charles, additional, Phan, Thanh G., additional, Bellut, Maximilian, additional, Abrigo, Jill, additional, Cheng, Cyrus, additional, Leung, Thomas W., additional, Chu, Winnie, additional, Chappell, Francesca, additional, Makin, Stephen D.J., additional, van Dam-Nolen, Dianne H.K., additional, Kooi, M. Eline, additional, Köhler, Sebastian, additional, Staals, Julie, additional, Kuchcinski, Grégory, additional, Bordet, Régis, additional, Dubost, Florian, additional, Wardlaw, Joanna M., additional, Soo, Yannie O.Y., additional, Fluri, Felix, additional, Srikanth, Velandai K., additional, Jung, Simon, additional, Peters, Nils, additional, Hara, Hideo, additional, Yakushiji, Yusuke, additional, Necioglu Orken, Dilek, additional, Heo, Ji-Hoe, additional, Lau, Gary Kui Kai, additional, Bae, Hee-Joon, additional, and Werring, David J., additional

Published
2024
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10. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Harkness, Kirsty, Shaw, Louise, Sword, Jane, Mohd Nor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Birns, Jonathan, Cohen, David, Sekaran, Lakshmanan, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, Sprigg, Nikola, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil, Shakeshaft, Clare, Brown, Martin, Charidimou, Andreas, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark, Yousry, Tarek, Flossmann, Enrico, Muir, Keith, El-Koussy, Marwan, Gratz, Pascal, Molad, Jeremy, Korczyn, Amos, Kliper, Efrat, Maeder, Philippe, Gass, Achim, Pachai, Chahin, Bracoub, Luc, Douste-Blazy, Marie-Yvonne, Fratacci, Marie Dominique, Vicaut, Eric, Sato, Shoichiro, Miwa, Kaori, Fujita, Kyohei, Ide, Toshihiro, Ma, Henry, Ly, John, Singhal, Shahoo, Chandra, Ronil, Slater, Lee-Anne, Soufan, Cathy, Moran, Christopher, Traenka, Christopher, Thilemann, Sebastian, Fladt, Joachim, Gensicke, Henrik, Bonati, Leo, Kim, Beom Joon, Han, Moon-Ku, Kang, Jihoon, Ko, Eunbin, Yang, Mi Hwa, Jang, Myung Suk, Murphy, Sean, Carty, Fiona, Akijian, Layan, Thornton, John, Schembri, Mark, Douven, Elles, Delgado-Mederos;, Raquel, Marín, Rebeca, Camps-Renom, Pol, Guisado-Alonso, Daniel, Nuñez, Fidel, Medrano-Martorell, Santiago, Merino, Elisa, Iida, Kotaro, Ikeda, Syuhei, Nishihara, Masashi, Irie, Hiroyuki, Demirelli, Derya Selcuk, Medanta, Jayesh Modi, Zerna, Charlotte, Hernández, Maria Valdés, Armitage, Paul, Heye, Anna, Muñoz-Maniega, Susana, Sakka, Eleni, Thrippleton, Michael, Dennis, Martin, Beigneux, Ysoline, Silva, Mauro, Venketasubramanian, Narayanaswamy, Ho, Shu Leung, Cheung, Raymond Tak Fai, Chan, Koon Ho, Teo, Kay Cheong, Hui, Edward, Kwan, Joseph Shiu Kwong, Chang, Richard, Tse, Man Yu, Hoi, Chu Peng, Chan, Chung Yan, Chan, Oi Ling, Cheung, Ryan Hoi Kit, Wong, Edmund Ka Ming, Leung, Kam Tat, Tsang, Suk Fung, Ip, Hing Lung, Ma, Sze Ho, Ma, Karen, Fong, Wing Chi, Li, Siu Hung, Li, Richard, Ng, Ping Wing, Wong, Kwok Kui, Liu, Wenyan, Wong, Lawrence, Ramos, Lino, De Schryver, Els, Jöbsis, Joost, van der Sande, Jaap, Brouwers, Paul, Roos, Yvo, Stam, Jan, Bakker, Stef, Verbiest, Henk, Schoonewille, Wouter, Linn, Cisca, Hertzberger, Leopold, van Gemert, Maarten, Berntsen, Paul, Hendrikse, Jeroen, Nederkoorn, Paul, Mess, Werner, Koudstaal, Peter, Leff, Alexander, Ward, Nicholas, Nachev, Parashkev, Perry, Richard, Ozkan, Hatice, Mitchell, John, Wilson, Duncan, Ambler, Gareth, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sánchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Schrooten, Maarten, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M, Assayag, Einor Ben, Hallevi, Hen, Tanaka, Jun, Hara, Hideo, Coutts, Shelagh B, Hert, Lisa, Polymeris, Alexandros, Seiffge, David J, Lyrer, Philippe, Algra, Ale, Kappelle, Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R, Lip, Gregory Y H, Mattle, Heinrich P, Panos, Leonidas D, Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J, Kooi, M Eline, van Dam-Nolen, Dianne H K, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M, Maaijwee, Noortje, Guevarra, Christine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Régis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, van der Lugt, Aad, Kelly, Peter J, Wardlaw, Joanna M, Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Engelter, Stefan T, Peters, Nils, Smith, Eric E, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M, Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, and Werring, David J

Published
2019
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15. Blood Pressure Control Targets and Risk of Cardiovascular and Cerebrovascular Events After Intracerebral Hemorrhage

Author

Teo, Kay-Cheong, primary, Keins, Sophia, additional, Abramson, Jessica R., additional, Leung, William C.Y., additional, Leung, Ian Y.H., additional, Wong, Yuen-Kwun, additional, Yeung, Charming, additional, Kourkoulis, Christina, additional, Warren, Andrew D., additional, Chan, Koon-Ho, additional, Cheung, Raymond T.F., additional, Ho, Shu-Leong, additional, Gurol, M. Edip, additional, Viswanathan, Anand, additional, Greenberg, Steven M., additional, Anderson, Christopher D., additional, Lau, Kui-Kai, additional, Rosand, Jonathan, additional, and Biffi, Alessandro, additional

Published
2023
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16. Lobar intracerebral hemorrhage and risk of subsequent uncontrolled blood pressure

Author

Myserlis, Evangelos Pavlos, primary, Mayerhofer, Ernst, additional, Abramson, Jessica R, additional, Teo, Kay-Cheong, additional, Montgomery, Bailey E., additional, Sugita, Lansing, additional, Warren, Andrew D, additional, Goldstein, Joshua N, additional, Gurol, Mahmut Edip, additional, Viswanathan, Anand, additional, Greenberg, Steven M, additional, Biffi, Alessandro, additional, Anderson, Christopher D, additional, and Rosand, Jonathan, additional

Published
2022
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17. Long‐Term Blood Pressure Variability and Major Adverse Cardiovascular and Cerebrovascular Events After Intracerebral Hemorrhage

Author

Castello, Juan Pablo, primary, Teo, Kay‐Cheong, additional, Abramson, Jessica R., additional, Keins, Sophia, additional, Takahashi, Courtney E., additional, Leung, Ian Y. H., additional, Leung, William C. Y., additional, Wang, Yujie, additional, Kourkoulis, Christina, additional, Pavlos Myserlis, Evangelos, additional, Warren, Andrew D., additional, Henry, Jonathan, additional, Chan, Koon‐Ho, additional, Cheung, Raymond T. F., additional, Ho, Shu‐Leong, additional, Gurol, M. Edip, additional, Viswanathan, Anand, additional, Greenberg, Steven M., additional, Anderson, Christopher D., additional, Lau, Kui‐Kai, additional, Rosand, Jonathan, additional, and Biffi, Alessandro, additional

Published
2022
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20. Low‐Density Lipoprotein Cholesterol and Risk of Recurrent Vascular Events in Chinese Patients With Ischemic Stroke With and Without Significant Atherosclerosis

Author

Lau, Kui‐Kai, primary, Chua, Bryan J., additional, Ng, Alexander, additional, Leung, Ian Yu‐Hin, additional, Wong, Yuen‐Kwun, additional, Chan, Anna Ho‐Yin, additional, Chiu, Yuen‐Kei, additional, Chu, Ariane Xia‐Wei, additional, Leung, William C. Y., additional, Tsang, Anderson Chun‐On, additional, Teo, Kay‐Cheong, additional, and Mak, Henry Ka‐Fung, additional

Published
2021
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21. Impact of Uncontrolled Hypertension at 3 Months After Intracerebral Hemorrhage

Author

Biffi, Alessandro, primary, Teo, Kay‐Cheong, additional, Castello, Juan Pablo, additional, Abramson, Jessica R., additional, Leung, Ian Y. H., additional, Leung, William C. Y., additional, Wang, Yujie, additional, Kourkoulis, Christina, additional, Myserlis, Evangelos Pavlos, additional, Warren, Andrew D., additional, Henry, Jonathan, additional, Chan, Koon‐Ho, additional, Cheung, Raymond T. F., additional, Ho, Shu‐Leong, additional, Anderson, Christopher D., additional, Gurol, M. Edip, additional, Viswanathan, Anand, additional, Greenberg, Steven M., additional, Lau, Kui‐Kai, additional, and Rosand, Jonathan, additional

Published
2021
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22. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Best, Jonathan G, primary, Ambler, Gareth, additional, Wilson, Duncan, additional, Lee, Keon-Joo, additional, Lim, Jae-Sung, additional, Shiozawa, Masayuki, additional, Koga, Masatoshi, additional, Li, Linxin, additional, Lovelock, Caroline, additional, Chabriat, Hugues, additional, Hennerici, Michael, additional, Wong, Yuen Kwun, additional, Mak, Henry Ka Fung, additional, Prats-Sanchez, Luis, additional, Martínez-Domeño, Alejandro, additional, Inamura, Shigeru, additional, Yoshifuji, Kazuhisa, additional, Arsava, Ethem Murat, additional, Horstmann, Solveig, additional, Purrucker, Jan, additional, Lam, Bonnie Yin Ka, additional, Wong, Adrian, additional, Kim, Young Dae, additional, Song, Tae-Jin, additional, Lemmens, Robin, additional, Eppinger, Sebastian, additional, Gattringer, Thomas, additional, Uysal, Ender, additional, Tanriverdi, Zeynep, additional, Bornstein, Natan M, additional, Ben Assayag, Einor, additional, Hallevi, Hen, additional, Molad, Jeremy, additional, Nishihara, Masashi, additional, Tanaka, Jun, additional, Coutts, Shelagh B, additional, Polymeris, Alexandros, additional, Wagner, Benjamin, additional, Seiffge, David J, additional, Lyrer, Philippe, additional, Algra, Ale, additional, Kappelle, L Jaap, additional, Al-Shahi Salman, Rustam, additional, Jäger, Hans R, additional, Lip, Gregory Y H, additional, Fischer, Urs, additional, El-Koussy, Marwan, additional, Mas, Jean-Louis, additional, Legrand, Laurence, additional, Karayiannis, Christopher, additional, Phan, Thanh, additional, Gunkel, Sarah, additional, Christ, Nicolas, additional, Abrigo, Jill, additional, Leung, Thomas, additional, Chu, Winnie, additional, Chappell, Francesca, additional, Makin, Stephen, additional, Hayden, Derek, additional, Williams, David J, additional, Mess, Werner H, additional, Nederkoorn, Paul J, additional, Barbato, Carmen, additional, Browning, Simone, additional, Wiegertjes, Kim, additional, Tuladhar, Anil M, additional, Maaijwee, Noortje, additional, Guevarra, Anne Cristine, additional, Yatawara, Chathuri, additional, Mendyk, Anne-Marie, additional, Delmaire, Christine, additional, Köhler, Sebastian, additional, van Oostenbrugge, Robert, additional, Zhou, Ying, additional, Xu, Chao, additional, Hilal, Saima, additional, Gyanwali, Bibek, additional, Chen, Christopher, additional, Lou, Min, additional, Staals, Julie, additional, Bordet, Régis, additional, Kandiah, Nagaendran, additional, de Leeuw, Frank-Erik, additional, Simister, Robert, additional, Hendrikse, Jeroen, additional, Kelly, Peter J, additional, Wardlaw, Joanna, additional, Soo, Yannie, additional, Fluri, Felix, additional, Srikanth, Velandai, additional, Calvet, David, additional, Jung, Simon, additional, Kwa, Vincent I H, additional, Engelter, Stefan T, additional, Peters, Nils, additional, Smith, Eric E, additional, Hara, Hideo, additional, Yakushiji, Yusuke, additional, Orken, Dilek Necioglu, additional, Fazekas, Franz, additional, Thijs, Vincent, additional, Heo, Ji Hoe, additional, Mok, Vincent, additional, Veltkamp, Roland, additional, Ay, Hakan, additional, Imaizumi, Toshio, additional, Gomez-Anson, Beatriz, additional, Lau, Kui Kai, additional, Jouvent, Eric, additional, Rothwell, Peter M, additional, Toyoda, Kazunori, additional, Bae, Hee-Joon, additional, Marti-Fabregas, Joan, additional, Werring, David J, additional, Harkness, Kirsty, additional, Shaw, Louise, additional, Sword, Jane, additional, Mohd Nor, Azlisham, additional, Sharma, Pankaj, additional, Kelly, Deborah, additional, Harrington, Frances, additional, Randall, Marc, additional, Smith, Matthew, additional, Mahawish, Karim, additional, Elmarim, Abduelbaset, additional, Esisi, Bernard, additional, Cullen, Claire, additional, Nallasivam, Arumug, additional, Price, Christopher, additional, Barry, Adrian, additional, Roffe, Christine, additional, Coyle, John, additional, Hassan, Ahamad, additional, Birns, Jonathan, additional, Cohen, David, additional, Sekaran, Lakshmanan, additional, Parry-Jones, Adrian, additional, Parry, Anthea, additional, Hargroves, David, additional, Proschel, Harald, additional, Datta, Prabel, additional, Darawil, Khaled, additional, Manoj, Aravindakshan, additional, Burn, Mathew, additional, Patterson, Chris, additional, Giallombardo, Elio, additional, Smyth, Nigel, additional, Mansoor, Syed, additional, Anwar, Ijaz, additional, Marsh, Rachel, additional, Ispoglou, Sissi, additional, Chadha, Dinesh, additional, Prabhakaran, Mathuri, additional, Meenakishundaram, Sanjeevikumar, additional, O'Connell, Janice, additional, Scott, Jon, additional, Krishnamurthy, Vinodh, additional, Aghoram, Prasanna, additional, McCormick, Michael, additional, Sprigg, Nikola, additional, O'Mahony, Paul, additional, Cooper, Martin, additional, Choy, Lillian, additional, Wilkinson, Peter, additional, Leach, Simon, additional, Caine, Sarah, additional, Burger, Ilse, additional, Gunathilagan, Gunaratam, additional, Guyler, Paul, additional, Emsley, Hedley, additional, Davis, Michelle, additional, Manawadu, Dulka, additional, Pasco, Kath, additional, Mamun, Maam, additional, Luder, Robert, additional, Sajid, Mahmud, additional, Okwera, James, additional, Warburton, Elizabeth, additional, Saastamoinen, Kari, additional, England, Timothy, additional, Putterill, Janet, additional, Flossman, Enrico, additional, Power, Michael, additional, Dani, Krishna, additional, Mangion, David, additional, Suman, Appu, additional, Corrigan, John, additional, Lawrence, Enas, additional, Vahidassr, Djamil, additional, Shakeshaft, Clare, additional, Brown, Martin, additional, Charidimou, Andreas, additional, Cohen, Hannah, additional, Banerjee, Gargi, additional, Houlden, Henry, additional, White, Mark, additional, Yousry, Tarek, additional, Flossmann, Enrico, additional, Muir, Keith, additional, Gratz, Pascal, additional, Mattle, Heinrich, additional, Panos, Leonidas, additional, Korczyn, Amos, additional, Kliper, Efrat, additional, Maeder, Philippe, additional, Gass, Achim, additional, Pachai, Chahin, additional, Bracoub, Luc, additional, Douste-Blazy, Marie-Yvonne, additional, Fratacci, Marie Dominique, additional, Vicaut, Eric, additional, Sato, Shoichiro, additional, Miwa, Kaori, additional, Fujita, Kyohei, additional, Ide, Toshihiro, additional, Ma, Henry, additional, Ly, John, additional, Singhal, Shaloo, additional, Chandra, Ronil, additional, Slater, Lee-Anne, additional, Soufan, Cathy, additional, Moran, Christopher, additional, Traenka, Christopher, additional, Thilemann, Sebastian, additional, Fladt, Joachim, additional, Gensicke, Henrik, additional, Bonati, Leo, additional, Kim, Beom Joon, additional, Han, Moon-Ku, additional, Kang, Jihoon, additional, Ko, Eunbin, additional, Yang, Mi Hwa, additional, Jang, Myung Suk, additional, Murphy, Sean, additional, Carty, Fiona, additional, Akijian, Layan, additional, Thornton, John, additional, Schembri, Mark, additional, Douven, Elles, additional, Delgado-Mederos, Raquel, additional, Marín, Rebeca, additional, Camps-Renom, Pol, additional, Guisado-Alonso, Daniel, additional, Nuñez, Fidel, additional, Medrano-Martorell, Santiago, additional, Merino, Elisa, additional, Iida, Kotaro, additional, Ikeda, Syuhei, additional, Irie, Hiroyuki, additional, Demirelli, Derya Selcuk, additional, Medanta, Jayesh Modi, additional, Zerna, Charlotte, additional, Hernández, Maria Valdés, additional, Armitage, Paul, additional, Heye, Anna, additional, Muñoz-Maniega, Susana, additional, Sakka, Eleni, additional, Thrippleton, Michael, additional, Dennis, Martin, additional, Beigneux, Ysoline, additional, Silva, Mauro, additional, Venketasubramanian, Narayanaswamy, additional, Ho, Shu Leung, additional, Cheung, Raymond Tak Fai, additional, Chan, Koon Ho, additional, Teo, Kay Cheong, additional, Hui, Edward, additional, Kwan, Joseph Shiu Kwong, additional, Chang, Richard, additional, Tse, Man Yu, additional, Hoi, Chu Peng, additional, Chan, Chung Yan, additional, Chan, Oi Ling, additional, Cheung, Ryan Hoi Kit, additional, Wong, Edmund Ka Ming, additional, Leung, Kam Tat, additional, Tsang, Suk Fung, additional, Ip, Hing Lung, additional, Ma, Sze Ho, additional, Ma, Karen, additional, Fong, Wing Chi, additional, Li, Siu Hung, additional, Li, Richard, additional, Ng, Ping Wing, additional, Wong, Kwok Kui, additional, Liu, Wenyan, additional, Wong, Lawrence, additional, Ramos, Lino, additional, De Schryver, Els, additional, Jöbsis, Joost, additional, van der Sande, Jaap, additional, Brouwers, Paul, additional, Roos, Yvo, additional, Stam, Jan, additional, Bakker, Stef, additional, Verbiest, Henk, additional, Schoonewille, Wouter, additional, Linn, Cisca, additional, Hertzberger, Leopold, additional, van Gemert, Maarten, additional, Berntsen, Paul, additional, Van Dam-Nolen, Dianne, additional, Kooi, M Eline, additional, Van der Lugt, Aad, additional, Koudstaal, Peter, additional, Leff, Alexander, additional, Ward, Nicholas, additional, Nachev, Parashkev, additional, Perry, Richard, additional, Ozkan, Hatice, additional, and Mitchell, John, additional

Published
2021
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23. Abstract P878: Racial and Ethnic Disparities in Early Hypertension Control After Intracerebral Hemorrhage

Author

Castello, Juan Pablo, primary, Teo, Kay Cheong, additional, Abramson, Jessica R, additional, Leung, Ian Y, additional, Leung, William Chun-yin, additional, Wang, Yujie, additional, Kourkoulis, Christina, additional, Myserlis, Evangelos Pavlos, additional, Warren, Andrew, additional, Henry, Jonathan, additional, Chan, Koon Ho H, additional, Cheung, Raymond, additional, Ho, Shu Leong, additional, Anderson, Christopher D, additional, Gurol, Edip M, additional, Viswanathan, Anand, additional, Greenberg, Steven M, additional, Lau, Kui Kai, additional, Rosand, Jonathan, additional, and Biffi, Alessandro, additional

Published
2021
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24. Abstract 15: Medication Inadequacy Accounts for Two-Third of Uncontrolled Hypertension Following Intracerebral Hemorrhage in a Multinational Study

Author

Teo, Kay Cheong, primary, Biffi, Alessandro, additional, Leung, Ian Y, additional, Leung, William C, additional, Wang, Yujie, additional, Kourkoulis, Christina, additional, Warren, Andrew, additional, Henry, Jonathan, additional, Chan, Koon Ho, additional, Cheung, Raymond T, additional, Ho, Shu Leong, additional, Gurol, Edip, additional, Viswanathan, Anand, additional, Greenberg, Steven M, additional, Anderson, Christopher D, additional, Lau, Kui Kai, additional, and Rosand, Jonathan, additional

Published
2020
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25. Low-Density Lipoprotein Cholesterol and Risk of Recurrent Vascular Events in Chinese Patients With Ischemic Stroke With and Without Significant Atherosclerosis.

Author

Kui-Kai Lau, Chua, Bryan J., Ng, Alexander, Yu-Hin Leung, Ian, Yuen-Kwun Wong, Ho-Yin Chan, Anna, Yuen-Kei Chiu, Xia-Wei Chu, Ariane, Leung, William C. Y., Chun-On Tsang, Anderson, Kay-Cheong Teo, Ka-Fung Mak, Henry, Lau, Kui-Kai, Leung, Ian Yu-Hin, Wong, Yuen-Kwun, Chan, Anna Ho-Yin, Chiu, Yuen-Kei, Chu, Ariane Xia-Wei, Tsang, Anderson Chun-On, and Teo, Kay-Cheong

Published
2021
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26. Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes

Author

Lau Kui-Kai, Wong Yuen-Kwun, Chan Yap-Hang, Yiu Kai-Hang, Teo Kay-Cheong, Li Leonard, Ho Shu-Leong, Chan Koon-Ho, Siu Chung-Wah, and Tse Hung-Fat

Subjects
Vascular markers of atherosclerosis, Type 2 diabetes mellitus, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Type 2 diabetes mellitus (T2DM) patients are at increased risk of developing cardiovascular events. Unfortunately traditional risk assessment scores, including the Framingham Risk Score (FRS), have only modest accuracy in cardiovascular risk prediction in these patients. Methods We sought to determine the prognostic values of different non-invasive markers of atherosclerosis, including brachial artery endothelial function, carotid artery atheroma burden, ankle-brachial index, arterial stiffness and computed tomography coronary artery calcium score (CACS) in 151 T2DM Chinese patients that were identified low-intermediate risk from the FRS recalibrated for Chinese ( Results A total of 17 atherosclerotic events in 16 patients (11%) occurred during the follow-up period. The mean FRS of the study population was 5.0 ± 4.6% and area under curve (AUC) from receiver operating characteristic curve analysis for prediction of atherosclerotic events was 0.59 ± 0.07 (P = 0.21). Among different vascular assessments, CACS > 40 had the best prognostic value (AUC 0.81 ± 0.06, P ) and offered significantly better accuracy in prediction compared with FRS (P = 0.038 for AUC comparisons). Combination of FRS with CACS or other surrogate vascular markers did not further improve the prognostic values over CACS alone. Multivariate Cox regression analysis identified CACS > 40 as an independent predictor of atherosclerotic events in T2DM patients (Hazards Ratio 27.11, 95% Confidence Interval 3.36-218.81, P = 0.002). Conclusions In T2DM patients identified as low-intermediate risk by the FRS, a raised CACS > 40 was an independent predictor for atherosclerotic events.

Published
2012
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27. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Wilson, Duncan, primary, Ambler, Gareth, additional, Lee, Keon-Joo, additional, Lim, Jae-Sung, additional, Shiozawa, Masayuki, additional, Koga, Masatoshi, additional, Li, Linxin, additional, Lovelock, Caroline, additional, Chabriat, Hugues, additional, Hennerici, Michael, additional, Wong, Yuen Kwun, additional, Mak, Henry Ka Fung, additional, Prats-Sánchez, Luis, additional, Martínez-Domeño, Alejandro, additional, Inamura, Shigeru, additional, Yoshifuji, Kazuhisa, additional, Arsava, Ethem Murat, additional, Horstmann, Solveig, additional, Purrucker, Jan, additional, Lam, Bonnie Yin Ka, additional, Wong, Adrian, additional, Kim, Young Dae, additional, Song, Tae-Jin, additional, Schrooten, Maarten, additional, Lemmens, Robin, additional, Eppinger, Sebastian, additional, Gattringer, Thomas, additional, Uysal, Ender, additional, Tanriverdi, Zeynep, additional, Bornstein, Natan M, additional, Assayag, Einor Ben, additional, Hallevi, Hen, additional, Tanaka, Jun, additional, Hara, Hideo, additional, Coutts, Shelagh B, additional, Hert, Lisa, additional, Polymeris, Alexandros, additional, Seiffge, David J, additional, Lyrer, Philippe, additional, Algra, Ale, additional, Kappelle, Jaap, additional, Al-Shahi Salman, Rustam, additional, Jäger, Hans R, additional, Lip, Gregory Y H, additional, Mattle, Heinrich P, additional, Panos, Leonidas D, additional, Mas, Jean-Louis, additional, Legrand, Laurence, additional, Karayiannis, Christopher, additional, Phan, Thanh, additional, Gunkel, Sarah, additional, Christ, Nicolas, additional, Abrigo, Jill, additional, Leung, Thomas, additional, Chu, Winnie, additional, Chappell, Francesca, additional, Makin, Stephen, additional, Hayden, Derek, additional, Williams, David J, additional, Kooi, M Eline, additional, van Dam-Nolen, Dianne H K, additional, Barbato, Carmen, additional, Browning, Simone, additional, Wiegertjes, Kim, additional, Tuladhar, Anil M, additional, Maaijwee, Noortje, additional, Guevarra, Christine, additional, Yatawara, Chathuri, additional, Mendyk, Anne-Marie, additional, Delmaire, Christine, additional, Köhler, Sebastian, additional, van Oostenbrugge, Robert, additional, Zhou, Ying, additional, Xu, Chao, additional, Hilal, Saima, additional, Gyanwali, Bibek, additional, Chen, Christopher, additional, Lou, Min, additional, Staals, Julie, additional, Bordet, Régis, additional, Kandiah, Nagaendran, additional, de Leeuw, Frank-Erik, additional, Simister, Robert, additional, van der Lugt, Aad, additional, Kelly, Peter J, additional, Wardlaw, Joanna M, additional, Soo, Yannie, additional, Fluri, Felix, additional, Srikanth, Velandai, additional, Calvet, David, additional, Jung, Simon, additional, Kwa, Vincent I H, additional, Engelter, Stefan T, additional, Peters, Nils, additional, Smith, Eric E, additional, Yakushiji, Yusuke, additional, Orken, Dilek Necioglu, additional, Fazekas, Franz, additional, Thijs, Vincent, additional, Heo, Ji Hoe, additional, Mok, Vincent, additional, Veltkamp, Roland, additional, Ay, Hakan, additional, Imaizumi, Toshio, additional, Gomez-Anson, Beatriz, additional, Lau, Kui Kai, additional, Jouvent, Eric, additional, Rothwell, Peter M, additional, Toyoda, Kazunori, additional, Bae, Hee-Joon, additional, Marti-Fabregas, Joan, additional, Werring, David J, additional, Harkness, Kirsty, additional, Shaw, Louise, additional, Sword, Jane, additional, Mohd Nor, Azlisham, additional, Sharma, Pankaj, additional, Kelly, Deborah, additional, Harrington, Frances, additional, Randall, Marc, additional, Smith, Matthew, additional, Mahawish, Karim, additional, Elmarim, Abduelbaset, additional, Esisi, Bernard, additional, Cullen, Claire, additional, Nallasivam, Arumug, additional, Price, Christopher, additional, Barry, Adrian, additional, Roffe, Christine, additional, Coyle, John, additional, Hassan, Ahamad, additional, Birns, Jonathan, additional, Cohen, David, additional, Sekaran, Lakshmanan, additional, Parry-Jones, Adrian, additional, Parry, Anthea, additional, Hargroves, David, additional, Proschel, Harald, additional, Datta, Prabel, additional, Darawil, Khaled, additional, Manoj, Aravindakshan, additional, Burn, Mathew, additional, Patterson, Chris, additional, Giallombardo, Elio, additional, Smyth, Nigel, additional, Mansoor, Syed, additional, Anwar, Ijaz, additional, Marsh, Rachel, additional, Ispoglou, Sissi, additional, Chadha, Dinesh, additional, Prabhakaran, Mathuri, additional, Meenakishundaram, Sanjeevikumar, additional, O'Connell, Janice, additional, Scott, Jon, additional, Krishnamurthy, Vinodh, additional, Aghoram, Prasanna, additional, McCormick, Michael, additional, Sprigg, Nikola, additional, O'Mahony, Paul, additional, Cooper, Martin, additional, Choy, Lillian, additional, Wilkinson, Peter, additional, Leach, Simon, additional, Caine, Sarah, additional, Burger, Ilse, additional, Gunathilagan, Gunaratam, additional, Guyler, Paul, additional, Emsley, Hedley, additional, Davis, Michelle, additional, Manawadu, Dulka, additional, Pasco, Kath, additional, Mamun, Maam, additional, Luder, Robert, additional, Sajid, Mahmud, additional, Okwera, James, additional, Warburton, Elizabeth, additional, Saastamoinen, Kari, additional, England, Timothy, additional, Putterill, Janet, additional, Flossman, Enrico, additional, Power, Michael, additional, Dani, Krishna, additional, Mangion, David, additional, Suman, Appu, additional, Corrigan, John, additional, Lawrence, Enas, additional, Vahidassr, Djamil, additional, Shakeshaft, Clare, additional, Brown, Martin, additional, Charidimou, Andreas, additional, Cohen, Hannah, additional, Banerjee, Gargi, additional, Houlden, Henry, additional, White, Mark, additional, Yousry, Tarek, additional, Flossmann, Enrico, additional, Muir, Keith, additional, El-Koussy, Marwan, additional, Gratz, Pascal, additional, Molad, Jeremy, additional, Korczyn, Amos, additional, Kliper, Efrat, additional, Maeder, Philippe, additional, Gass, Achim, additional, Pachai, Chahin, additional, Bracoub, Luc, additional, Douste-Blazy, Marie-Yvonne, additional, Fratacci, Marie Dominique, additional, Vicaut, Eric, additional, Sato, Shoichiro, additional, Miwa, Kaori, additional, Fujita, Kyohei, additional, Ide, Toshihiro, additional, Ma, Henry, additional, Ly, John, additional, Singhal, Shahoo, additional, Chandra, Ronil, additional, Slater, Lee-Anne, additional, Soufan, Cathy, additional, Moran, Christopher, additional, Traenka, Christopher, additional, Thilemann, Sebastian, additional, Fladt, Joachim, additional, Gensicke, Henrik, additional, Bonati, Leo, additional, Kim, Beom Joon, additional, Han, Moon-Ku, additional, Kang, Jihoon, additional, Ko, Eunbin, additional, Yang, Mi Hwa, additional, Jang, Myung Suk, additional, Murphy, Sean, additional, Carty, Fiona, additional, Akijian, Layan, additional, Thornton, John, additional, Schembri, Mark, additional, Douven, Elles, additional, Delgado-Mederos;, Raquel, additional, Marín, Rebeca, additional, Camps-Renom, Pol, additional, Guisado-Alonso, Daniel, additional, Nuñez, Fidel, additional, Medrano-Martorell, Santiago, additional, Merino, Elisa, additional, Iida, Kotaro, additional, Ikeda, Syuhei, additional, Nishihara, Masashi, additional, Irie, Hiroyuki, additional, Demirelli, Derya Selcuk, additional, Medanta, Jayesh Modi, additional, Zerna, Charlotte, additional, Hernández, Maria Valdés, additional, Armitage, Paul, additional, Heye, Anna, additional, Muñoz-Maniega, Susana, additional, Sakka, Eleni, additional, Thrippleton, Michael, additional, Dennis, Martin, additional, Beigneux, Ysoline, additional, Silva, Mauro, additional, Venketasubramanian, Narayanaswamy, additional, Ho, Shu Leung, additional, Cheung, Raymond Tak Fai, additional, Chan, Koon Ho, additional, Teo, Kay Cheong, additional, Hui, Edward, additional, Kwan, Joseph Shiu Kwong, additional, Chang, Richard, additional, Tse, Man Yu, additional, Hoi, Chu Peng, additional, Chan, Chung Yan, additional, Chan, Oi Ling, additional, Cheung, Ryan Hoi Kit, additional, Wong, Edmund Ka Ming, additional, Leung, Kam Tat, additional, Tsang, Suk Fung, additional, Ip, Hing Lung, additional, Ma, Sze Ho, additional, Ma, Karen, additional, Fong, Wing Chi, additional, Li, Siu Hung, additional, Li, Richard, additional, Ng, Ping Wing, additional, Wong, Kwok Kui, additional, Liu, Wenyan, additional, Wong, Lawrence, additional, Ramos, Lino, additional, De Schryver, Els, additional, Jöbsis, Joost, additional, van der Sande, Jaap, additional, Brouwers, Paul, additional, Roos, Yvo, additional, Stam, Jan, additional, Bakker, Stef, additional, Verbiest, Henk, additional, Schoonewille, Wouter, additional, Linn, Cisca, additional, Hertzberger, Leopold, additional, van Gemert, Maarten, additional, Berntsen, Paul, additional, Hendrikse, Jeroen, additional, Nederkoorn, Paul, additional, Mess, Werner, additional, Koudstaal, Peter, additional, Leff, Alexander, additional, Ward, Nicholas, additional, Nachev, Parashkev, additional, Perry, Richard, additional, Ozkan, Hatice, additional, and Mitchell, John, additional

Published
2019
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28. Long‐Term Prognostic Implications of Cerebral Microbleeds in Chinese Patients With Ischemic Stroke

Author

Lau, Kui Kai, primary, Wong, Yuen Kwun, additional, Teo, Kay Cheong, additional, Chang, Richard S. K., additional, Tse, Man Yu, additional, Hoi, Chu Peng, additional, Chan, Chung Yan, additional, Chan, Oi Ling, additional, Cheung, Ryan Hoi Kit, additional, Wong, Edmund Ka Ming, additional, Kwan, Joseph Shiu Kwong, additional, Hui, Edward S., additional, and Mak, Henry Ka Fung, additional

Published
2017
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30. Visit-to-visit blood pressure variability as a prognostic marker in patients with cardiovascular and cerebrovascular diseases – Relationships and comparisons with vascular markers of atherosclerosis

Author

Lau, Kui Kai, primary, Wong, Yuen Kwun, additional, Chan, Yap Hang, additional, Teo, Kay Cheong, additional, Chan, Koon Ho, additional, Wai Li, Leonard Sheung, additional, Cheung, Raymond Tak Fai, additional, Siu, Chung Wah, additional, Ho, Shu Leong, additional, and Tse, Hung Fat, additional

Published
2014
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34. Stroke Patients with a Past History of Cancer Are at Increased Risk of Recurrent Stroke and Cardiovascular Mortality

Author

Lau, Kui-Kai, primary, Wong, Yuen-Kwun, additional, Teo, Kay-Cheong, additional, Chang, Richard Shek-Kwan, additional, Hon, Sonny Fong-Kwong, additional, Chan, Koon-Ho, additional, Cheung, Raymond Tak-Fai, additional, Li, Leonard Sheung-Wai, additional, Tse, Hung-Fat, additional, Ho, Shu-Leong, additional, and Siu, Chung-Wah, additional

Published
2014
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37. Correlation of sputum inflammatory markers with severity and blood inflammatory markers in bronchiectasis.

Author

Kwok WC, Lau KK, Teo KC, and Ho JCM

Abstract

Background: As a disease characterized by chronic neutrophilic inflammation, various sputum biomarkers have been investigated in the association with the severity and prognosis of bronchiectasis. However, there is lack of data on the association between sputum interleukin-1beta (IL-1β), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) levels at clinical stable state and the clinical, spirometric and blood inflammatory parameters, as well as prognostic scores. The purpose of the study is to assess the association between sputum IL-1β, IL-8 and TNF-α levels at clinical stable state and various clinical and laboratory parameters in bronchiectasis., Methods: A prospective study was conducted in a major regional hospital and tertiary respiratory referral centre in Hong Kong, including 44 Chinese patients with bronchiectasis. The correlation between stable state sputum IL-1β, IL-8 and TNF-α levels with various clinical, laboratory and spirometric parameters in bronchiectasis, as well as FACED [forced expiratory volume in one second (FEV 1 ), age, chronic colonisation by Pseudomonas aeruginosa , radiological extension and dyspnoea]/E-FACED (FACED plus exacerbations) scores were assessed., Results: Baseline sputum IL-1β level was found to have significant moderate positive correlation with baseline blood high sensitivity C-reactive protein (hs-CRP) level with Pearson correlation coefficient (r) of 0.529 (P=0.001). Baseline sputum IL-8 level was found to have significant moderate positive correlation with baseline FACED and E-FACED score with r of 0.574 (P<0.001) and 0.539 (P<0.001) respectively. Baseline sputum TNF-α level was found to have significant moderate positive correlation with baseline FACED score with r of 0.520 (P<0.001)., Conclusions: Sputum IL-1β and, IL-8 and TNF-α levels were shown to have significant correlation with various clinical, laboratory and spirometry parameters in bronchiectasis, as well as more severe disease as measured by FACED and E-FACED scores., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-24-573/coif). W.C.K. reports that the study was supported by the Hong Kong College of Physicians Young Investigator Research Grant, Hong Kong College of Physicians. The other authors have no conflicts of interest to declare., (2024 Journal of Thoracic Disease. All rights reserved.)

Published
2024
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38. Impact of renal function variability on long-term prognosis in ischemic stroke patients with atrial fibrillation.

Author

Wang X, Sin CF, Teo KC, Leung WCY, Wong YK, Liu RKC, Fok JW, Ip BY, Kwan HH, Lee TC, Sheng B, Yip EK, Yap DYH, Luo H, and Lau KK

Abstract

Background: Although renal dysfunction is associated with adverse clinical outcomes in patients with atrial fibrillation (AF) following stroke, the impact of renal function variability is unclear., Aim: This study aimed to assess the association between renal function variability and various adverse clinical outcomes in patients with transient ischemic attack (TIA)/ischemic stroke and atrial fibrillation (AF)., Methods: We conducted a population-based study and retrospectively identified patients hospitalized with a diagnosis of TIA/ischemic stroke and AF during 2016-2020 using the Clinical Data Analysis and Reporting System of Hong Kong. Serial serum creatinine tested upon the onset of TIA/ischemic stroke and during their subsequent follow-up was collected. Renal function variability was calculated using the coefficient of variation of the estimated glomerular filtration rate (eGFR). Clinical endpoints that occurred during the study period were captured and included ischemic stroke/systemic embolism, intracerebral hemorrhage (ICH), total bleeding, major adverse cardiovascular events (MACE), cardiovascular, non-cardiovascular, and all-cause mortality. Competing risk regression and Cox proportional hazard regression models were used to assess the associations of renal function variability with the outcomes of interest., Results: A total of 3,809 patients (mean age 80 ± 10 years, 43% men) who satisfied the inclusion and exclusion criteria were followed up for a mean of 2.5 ± 1.5 years (9,523 patient-years). The mean eGFR was 66 ± 22 mL/min/1.73 m 2 at baseline, and the median number of renal function tests per patient during the follow-up period was 20 (interquartile range 11-35). After accounting for potential confounders, a greater eGFR variability was associated with increased risks of recurrent ischemic stroke/systemic embolism [fully adjusted subdistribution hazard ratio 1.11, 95% confidence interval (CI) 1.03-1.20], ICH (1.17, 1.01-1.36), total bleeding (1.13, 1.06-1.21), MACE (1.22, 1.15-1.30), cardiovascular (1.49, 1.32-1.69), non-cardiovascular (1.43, 1.35-1.52), and all-cause mortality (fully adjusted hazard ratio 1.44, 1.39-1.50)., Conclusion: Visit-to-visit renal function variability is independently associated with adverse clinical outcomes in TIA/ischemic stroke patients with AF. Further large-scale studies are needed to validate our results., Competing Interests: K-KL received grants from Research Fund Secretariat of the Food and Health Bureau, Innovation and Technology Bureau, Research Grants Council and Eisai; and consultation fees from Amgen, Boehringer Ingelheim, Daiichi Sankyo and Sanofi, all outside the submitted work. BI received grants from Research Grants Council that is outside the submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Wang, Sin, Teo, Leung, Wong, Liu, Fok, Ip, Kwan, Lee, Sheng, Yip, Yap, Luo and Lau.)

Published
2024
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39. Long-term prognostic implications of visit-to-visit blood pressure variability in patients with ischemic stroke.

Author

Lau KK, Wong YK, Teo KC, Chang RS, Chan KH, Hon SF, Wat KL, Cheung RT, Li LS, Siu CW, and Tse HF

Subjects
Aged, Blood Pressure Determination, Brain Ischemia etiology, Brain Ischemia mortality, Cause of Death trends, Female, Follow-Up Studies, Hong Kong epidemiology, Humans, Hypertension complications, Hypertension mortality, Male, Prognosis, Prospective Studies, Risk Factors, Survival Rate trends, Time Factors, Blood Pressure physiology, Brain Ischemia physiopathology, Hypertension physiopathology, Office Visits
Abstract

Background: Blood pressure (BP) variability (BPV) is a novel risk factor for the development of atherosclerotic diseases. High BPV has recently been shown to predict all-cause and cardiovascular mortality in patients with lacunar infarct. Whether BPV has prognostic implications in patients with ischemic stroke subtypes, other than those due to small-vessel occlusion, remains uncertain., Methods: We prospectively followed up the clinical outcome of 632 consecutive ischemic stroke patients without atrial fibrillation. The average BP and BPV, as determined by the coefficient of variation of the systolic and diastolic BP, were recorded during a mean 12 ± 6 outpatient clinic visits., Results: The average age of the population was 71 ± 11 years. After a mean of 76 ± 18 months of follow-up, 161 patients died (26%); 35% (n = 56 of 161) of these deaths were due to cardiovascular causes. Sixteen percent and 5% developed recurrent stroke and acute coronary syndrome (ACS), respectively. After adjusting for mean systolic BP and confounding variables, patients with high systolic BPV were at significantly greater risk of cardiovascular mortality (hazards ratio (HR) = 2.36; 95% confidence interval (CI) = 1.02-5.49; P < 0.05). High systolic BPV also predicted all-cause mortality after adjusting for mean systolic BP (HR = 1.79; 95% CI = 1.16-2.75; P < 0.05). There was no association between systolic BPV and nonfatal recurrent stroke or nonfatal ACS. Raised diastolic BPV did not predict recurrent nonfatal stroke, nonfatal ACS, or mortality., Conclusions: Visit-to-visit systolic BPV predicts long-term all-cause and cardiovascular mortality in patients with ischemic stroke without atrial fibrillation, independent of other conventional risk factors, including average BP control., (© American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Published
2014
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