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4. Current frailty knowledge, awareness, and practices among physicians following the 2022 European consensus document on Frailty in Cardiology.

Author

Jie Jun Wong, Laureen Yi-Ting Wang, Koji Hasegawa, Kay Woon Ho, Zijuan Huang, Teo, Louis L.Y., Jack Wei Chieh Tan, Kazuyuki Kasahara, Ru-San Tan, Junbo Ge, and Koh, Angela S.

Subjects
FRAILTY, HEALTH care teams, PHYSICIANS, CARDIOLOGISTS, CARDIOLOGY, HEART failure
Abstract

Aims: Aging-related cardiovascular disease and frailty burdens are anticipated to rise with global aging. In response to directions from major cardiovascular societies, we investigated frailty knowledge, awareness, and practices among cardiologists as key stakeholders in this emerging paradigm a year after the European Frailty in Cardiology consensus document was published. Methods and results: We launched a prospective multinational web-based survey via social networks to broad cardiology communities representing multiple World Health Organization regions, including Western Pacific and Southeast Asia regions. Overall, 578 respondents [38.2% female; ages 35-49 years (55.2%) and 50-64 years (34.4%)] across subspecialties, including interventionists (43.3%), general cardiologists (30.6%), and heart failure specialists (HFSs) (10.9%), were surveyed. Nearly half had read the consensus document (38.9%). Non-interventionists had better perceived knowledge of frailty assessment instruments (fully or vaguely aware, 57.2% vs. 45%, adj. P = 0.0002), exercise programmes (well aware, 12.9% vs. 6.0%, adj. P = 0.001), and engaged more in multidisciplinary team care (frequently or occasionally, 52.6% vs. 41%, adj. P = 0.002) than interventionists. Heart failure specialists more often addressed pre-procedural frailty (frequently or occasionally, 43.5% vs. 28.2%, P = 0.004) and polypharmacy (frequently or occasionally, 85.5% vs. 71%, adj. P = 0.014) and had consistently better composite knowledge (39.3% vs. 21.6%, adj. P = 0.001) and practice responses (21% vs. 11.1%, adj. P = 0.018) than non-HFSs. Respondents with better knowledge responses also had better frailty practices (40.3% vs. 3.6%, adj. P < 0.001). Conclusion: Distinct response differences suggest that future strategies strengthening frailty principles should address practices peculiar to subspecialties, such as pre-procedural frailty strategies for interventionists and rehabilitation interventions for HFSs. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Socioeconomic Status and Outcomes in Heart Failure With Reduced Ejection Fraction From Asia

Author

Teng, Tiew-Hwa K., primary, Tay, Wan Ting, additional, Richards, Arthur Mark, additional, Chew, Timothy Shi Ming, additional, Anand, Inder, additional, Ouwerkerk, Wouter, additional, Chandramouli, Chanchal, additional, Huang, Weiting, additional, Lawson, Claire A., additional, Kadam, Umesh T., additional, Yap, Jonathan, additional, Lim, Shirlynn, additional, Hung, Chung-Lieh, additional, MacDonald, Michael Ross, additional, Loh, Seet Yoong, additional, Shimizu, Wataru, additional, Tromp, Jasper, additional, Lam, Carolyn Su Ping, additional, Ling, Lieng Hsi, additional, Liew, Houng Bang, additional, Narasimhan, Calambur, additional, Ngarmukos, Tachapong, additional, Park, Sang Weon, additional, Reyes, Eugenio, additional, Siswanto, Bambang B., additional, Zhang, Shu, additional, Fan, Xiaohan, additional, Chen, Keping, additional, Wu, Liqun, additional, Xie, Yucai, additional, Jin, Qi, additional, Ling, Tianyou, additional, Li, Xinli, additional, Zhou, Fang, additional, Zhou, Yanli, additional, Xu, Dongjie, additional, Zhang, Haifeng, additional, Su, Yangang, additional, Chen, Xueying, additional, Qin, Shengmei, additional, Wang, Jingfeng, additional, Gong, Xue, additional, Wu, Zhaodi, additional, Yu, Cheuk Man, additional, Sastry, B K S, additional, Gopi, Arun, additional, Raghu, K, additional, Sridevi, C, additional, Kaur, Daljeet, additional, Naik, Ajay, additional, Parikh, Keyur, additional, Chandarana, Anish, additional, Shah, Urmil, additional, Chag, Milan, additional, Baxi, Hemang, additional, Gupta, Satya, additional, Bhatia, Jyoti, additional, Khakhkhar, Vaishali, additional, Sankhla, Vineet, additional, Patel, Tejas, additional, Kapoor, Vipul, additional, Wander, Gurpreet Singh, additional, Tandon, Rohit, additional, Chopra, Vijay, additional, Kumar, Manoj, additional, Singh Sethi, Hatinder Jeet, additional, Verma, Rashmi, additional, Mittal, Sanjay, additional, Sawhney, Jitendra, additional, Sharma, Manish Kr., additional, Purayil, Mohanan Padinhare, additional, Siswanto, Bambang Budi, additional, Sadikin, RS Dr Hasan, additional, Tedjokusumo, Pintoko, additional, Martanto, Erwan, additional, Munawar, Muhammad, additional, Pambudi, Jimmy Agung, additional, Karawaci, RS Siloam, additional, Lukito, Antonia, additional, Pardede, Ingrid, additional, Thengker, Alvin, additional, Damay, Vito, additional, Danny, Siska Suridanda, additional, Surarso, Rarsari, additional, Noda, Takashi, additional, Nakajima, Ikutaro, additional, Wada, Mitsuru, additional, Ishibashi, Kohei, additional, Kurita, Takashi, additional, Yasuoka, Ryoubun, additional, Asai, Kuniya, additional, Murai, Kohji, additional, Kubota, Yoshiaki, additional, Izumi, Yuki, additional, Ikeda, Takanori, additional, Hisatake, Shinji, additional, Kabuki, Takayuki, additional, Kiuchi, Shunsuke, additional, Hagiwara, Nobuhisa, additional, Suzuki, Atsushi, additional, Suzuki, Dr Tsuyoshi, additional, Park, Sang-Weon, additional, Hong, Suk Keun, additional, Lee, SookJin, additional, Soo, Lim Dal, additional, Kim, Dong-Hyeok, additional, Shim, Jaemin, additional, Park, Seong-Mi, additional, Roh, Seung-Young, additional, Kim, Young Hoon, additional, Kim, Mina, additional, Choi, Jong-Il, additional, Na, Jin Oh, additional, Rha, Seung Woon, additional, Seo, Hong Seog, additional, Oh, Dong Joo, additional, Park, Chang Gyu, additional, Kim, Eung Ju, additional, Lee, Sunki, additional, Joung, Boyoung, additional, Uhm, Jae-Sun, additional, Lee, Moon Hyoung, additional, Cho, In-Jeong, additional, Park, Hui-Nam, additional, Park, Hyung-Wook, additional, Cho, Jeong-Gwan, additional, Yoon, Namsik, additional, Lee, KiHong, additional, Kim, Kye Hun, additional, Kim, Seong Hwan, additional, Saharudin, Sahrin, additional, Beh, Boon Cong, additional, Lee, Yu Wei, additional, Yen, Chia How, additional, Othman, Mohd Khairi, additional, Augustine, Amie-Anne, additional, Mohd Asnawi, Mohd Hariz, additional, Mojolou, Roberto Angelo, additional, Tan, You Zhuan, additional, Arbain, Aida Nurbaini, additional, Wong, Chii Koh, additional, Omar, Razali, additional, Ghazi, Azmee Mohd, additional, Khelae, Surinder Kaur, additional, Chew, David S.P., additional, Yap, Lok Bin, additional, Hussin, Azlan, additional, Muhammad, Zulkeflee, additional, Azmee, Mohd. Ghazi, additional, Abidin, Imran Zainal, additional, Mahmood Zhudi, Ahmad Syadi Bin, additional, Md Sari, Nor Ashikin, additional, Sridhar, Ganiga Srinivasaiah, additional, Mahmood Zuhdi, Ahmad Syadi, additional, Ismail, Muhammad Dzafir, additional, Ong, Tiong Kiam, additional, Cham, Yee Ling, additional, Khiew, Ning Zan, additional, Said, Asri Bin, additional, Yip Fong, Alan Yean, additional, Mohd Amin, Nor Hanim, additional, Seng, Keong Chua, additional, Tan, Sian Kong, additional, Yew, Kuan Leong, additional, Santos, Jones, additional, Lim, Allan, additional, Lapitan, Raul, additional, Andal, Ryan, additional, Lopez, Eleanor, additional, David Sim, Kheng Leng, additional, Tan, Boon Yew, additional, Lim, Choon Pin, additional, Teo, Louis L.Y., additional, Chan, Laura L.H., additional, Chai, Ping, additional, Raymond Wong, Ching Chiew, additional, Poh, Kian Keong, additional, Daniel Yeo, Poh Shuan, additional, Lee, Evelyn M., additional, Ching, Min Er, additional, Khoo, Deanna Z.L., additional, Yew, Min Sen, additional, Huang, Wenjie, additional, Gerard Leong, Kui Toh, additional, Jason See, Jia Hao, additional, Lim, Yaozong Benji, additional, Tan, Svenszeat, additional, Yeo, Colin, additional, Chai, Siang Chew, additional, Jaufeerally, Fazlur Rehman, additional, Tulsidas, Haresh, additional, Aung, Than, additional, Ong, Hean Yee, additional, Ling, Lee Fong, additional, Soon, Dinna Kar Nee, additional, Yeh, Hung-I, additional, Kuo, Jen-Yuan, additional, Yen, Chih-Hsuan, additional, Hwang, Juey-Jen, additional, Chien, Kuo-Liong, additional, Su, Ta-Chen, additional, Lin, Lian-Yu, additional, Juang, Jyh-Ming, additional, Lin, Yen-Hung, additional, Chiang, Fu-Tien, additional, Lin, Jiunn-Lee, additional, Ho, Yi-Lwun, additional, Lee, Chii-Ming, additional, Lin, Po-Chih, additional, Hung, Chi-Sheng, additional, Chang, Sheng-Nan, additional, Lin, Jou-Wei, additional, Hsu, Chih-Neng, additional, Yu, Wen-Chung, additional, Chao, Tze-Fan, additional, Sung, Shih-Hsien, additional, Wang, Kang-Ling, additional, Leu, Hsin-Bang, additional, Lin, Yenn-Jiang, additional, Chang, Shih-Lin, additional, Huang, Po-Hsun, additional, Lo, Li-Wei, additional, Wu, Cheng-Hsueh, additional, Liang, Hsin-Yueh, additional, Chang, Shih-Sheng, additional, Hsiao, Lien-Cheng, additional, Wang, Yu-Chen, additional, Lu, Chiung-Ray, additional, Wu, Hung-Pin, additional, Lin, Yen-Nien, additional, Chen, Ke-Wei, additional, Lo, Ping-Han, additional, Hsu, Chung-Ho, additional, Hsieh, Li-Chuan, additional, Chandavimol, Mann, additional, Yingchoncharoen, Teerapat, additional, Laothavorn, Prasart, additional, Tiyanon, Waraporn, additional, Wongcharoen, Wanwarang, additional, and Phrommintikul, Arintaya, additional

Published
2021
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8. Regional Variation of Mortality in Heart Failure With Reduced and Preserved Ejection Fraction Across Asia: Outcomes in the ASIAN‐HF Registry

Author

MacDonald, Michael R., primary, Tay, Wan Ting, additional, Teng, Tiew‐Hwa Katherine, additional, Anand, Inder, additional, Ling, Lieng Hsi, additional, Yap, Jonathan, additional, Tromp, Jasper, additional, Wander, Gurpreet S., additional, Naik, Ajay, additional, Ngarmukos, Tachapong, additional, Siswanto, Bambang B., additional, Hung, Chung‐Lieh, additional, Richards, A. Mark, additional, Lam, Carolyn S. P., additional, Liew, Houng Bang, additional, Narasimhan, Calambur, additional, Park, Sang Weon, additional, Reyes, Eugenio, additional, Shimizu, Wataru, additional, Zhang, Shu, additional, Wu, Liqun, additional, Ling, Tianyou, additional, Li, Xinli, additional, Zhang, Haifeng, additional, Su, Yangang, additional, Yu, Cheuk Man, additional, Sastry, B K S, additional, Gopi, Arun, additional, Raghu, K, additional, Sridevi, C, additional, Kaur, Daljeet, additional, Parikh, Keyur, additional, Chandarana, Anish, additional, Shah, Urmil, additional, Chag, Milan, additional, Baxi, Hemang, additional, Gupta, Satya, additional, Bhatia, Jyoti, additional, Khakhkhar, Vaishali, additional, Sankhla, Vineet, additional, Patel, Tejas, additional, Kapoor, Vipul, additional, Tandon, Rohit, additional, Chopra, Vijay, additional, Kumar, Manoj, additional, Sethi, Hatinder Jeet Singh, additional, Verma, Rashmi, additional, Sawhney, Jitendra, additional, Sharma, Manish Kr., additional, Purayil, Mohanan Padinhare, additional, Munawar, Muhammad, additional, Pambudi, Jimmy Agung, additional, Lukito, Antonia, additional, Pardede, Ingrid, additional, Thengker, Alvin, additional, Damay, Vito, additional, Danny, Siska Suridanda, additional, Surarso, Rarsari, additional, Yasuoka, Ryoubun, additional, Asai, Kuniya, additional, Ikeda, Takanori, additional, Park, Sang‐Weon, additional, Hong, Suk Keun, additional, Lee, SookJin, additional, Soo, Lim Dal, additional, Kim, Dong‐Hyeok, additional, Shim, Jaemin, additional, Park, Seong‐Mi, additional, Roh, Seung‐Young, additional, Kim, Young Hoon, additional, Kim, Mina, additional, Choi, Jong‐Il, additional, Na, Jin Oh, additional, Rha, Seung Woon, additional, Seo, Hong Seog, additional, Oh, Dong Joo, additional, Park, Chang Gyu, additional, Kim, Eung Ju, additional, Lee, Sunki, additional, Joung, Boyoung, additional, Uhm, Jae‐Sun, additional, Lee, Moon Hyoung, additional, Cho, In‐Jeong, additional, Park, Hui‐Nam, additional, Park, Hyung‐Wook, additional, Cho, Jeong‐Gwan, additional, Yoon, Namsik, additional, Lee, KiHong, additional, Kim, Kye Hun, additional, Kim, Seong Hwan, additional, Saharudin, Sahrin, additional, Beh, Boon Cong, additional, Lee, Yu Wei, additional, Yen, Chia How, additional, Othman, Mohd Khairi, additional, Augustine, Amie‐Anne, additional, Asnawi, Mohd Hariz Mohd, additional, Mojolou, Roberto Angelo, additional, Tan, You Zhuan, additional, Arbain, Aida Nurbaini, additional, Wong, Chii Koh, additional, Ghazi, Azmee Mohd, additional, Khelae, Surinder Kaur, additional, Chew, David S.P., additional, Yap, Lok Bin, additional, Hussin, Azlan, additional, Muhammad, Zulkeflee, additional, Abidin, Imran Zainal, additional, Zhudi, Ahmad Syadi Bin Mahmood, additional, Sari, Nor Ashikin Md, additional, Sridhar, Ganiga Srinivasaiah, additional, Zuhdi, Ahmad Syadi Mahmood, additional, Ismail, Muhammad Dzafir, additional, Ong, Tiong Kiam, additional, Cham, Yee Ling, additional, Khiew, Ning Zan, additional, Said, Asri Bin, additional, Fong, Alan Yean Yip, additional, Amin, Nor Hanim Mohd, additional, Seng, Keong Chua, additional, Tan, Sian Kong, additional, Yew, Kuan Leong, additional, Santos, Jones, additional, Lim, Allan, additional, Lapitan, Raul, additional, Andal, Ryan, additional, Lopez, Eleanor, additional, Sim, Kheng Leng David, additional, Tan, Boon Yew, additional, Lim, Choon Pin, additional, Teo, Louis L.Y., additional, Chan, Laura L. H., additional, Chai, Ping, additional, Wong, Ching Chiew Raymond, additional, Poh, Kian Keong, additional, Yeo, Poh Shuan Daniel, additional, Lee, Evelyn M., additional, Loh, Seet Yong, additional, Ching, Min Er, additional, Khoo, Deanna Z.L., additional, Yew, Min Sen, additional, Huang, Wenjie, additional, See, Jia Hao Jason, additional, Lim, Yaozong Benji, additional, Tan, Svenszeat, additional, Yeo, Colin, additional, Chai, Siang Chew, additional, Jaufeerally, Fazlur Rehman, additional, Tulsidas, Haresh, additional, Aung, Than, additional, Ong, Hean Yee, additional, Ling, Lee Fong, additional, Soon, Dinna Kar Nee, additional, Yeh, Hung‐I, additional, Kuo, Jen‐Yuan, additional, Yen, Chih‐Hsuan, additional, Hwang, Juey‐Jen, additional, Chien, Kuo‐Liong, additional, Su, Ta‐Chen, additional, Lin, Lian‐Yu, additional, Juang, Jyh‐Ming, additional, Lin, Yen‐Hung, additional, Chiang, Fu‐Tien, additional, Lin, Jiunn‐Lee, additional, Ho, Yi‐Lwun, additional, Lee, Chii‐Ming, additional, Lin, Po‐Chih, additional, Hung, Chi‐Sheng, additional, Chang, Sheng‐Nan, additional, Lin, Jou‐Wei, additional, Hsu, Chih‐Neng, additional, Yu, Wen‐Chung, additional, Chao, Tze‐Fan, additional, Sung, Shih‐Hsien, additional, Wang, Kang‐Ling, additional, Leu, Hsin‐Bang, additional, Lin, Yenn‐Jiang, additional, Chang, Shih‐Lin, additional, Huang, Po‐Hsun, additional, Lo, Li‐Wei, additional, Wu, Cheng‐Hsueh, additional, Liang, Hsin‐Yueh, additional, Chang, Shih‐Sheng, additional, Hsiao, Lien‐Cheng, additional, Wang, Yu‐Chen, additional, Lu, Chiung‐Ray, additional, Wu, Hung‐Pin, additional, Lin, Yen‐Nien, additional, Chen, Ke‐Wei, additional, Lo, Ping‐Han, additional, Hsu, Chung‐Ho, additional, Hsieh, Li‐Chuan, additional, Chandavimol, Mann, additional, Yingchoncharoen, Teerapat, additional, Laothavorn, Prasart, additional, Wongcharoen, Wanwarang, additional, and Phrommintikul, Arintaya, additional

Published
2020
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12. Water Conservation Overrides Osmotic Diuresis During SGLT2 Inhibition in Patients With Heart Failure.

Author

Marton, Adriana, Saffari, Seyed Ehsan, Rauh, Manfred, Sun, Ruo-Ning, Nagel, Armin M., Linz, Peter, Lim, Tzy Tiing, Takase-Minegishi, Kaoru, Pajarillaga, Anastacia, Saw, Sharon, Morisawa, Norihiko, Yam, Wan Keat, Minegishi, Shintaro, Totman, John J., Teo, Serena, Teo, Louis L.Y., Ng, Choon Ta, Kitada, Kento, Wild, Johannes, and Kovalik, Jean-Paul

Subjects
*DAPAGLIFLOZIN, *WATER conservation, *SODIUM-glucose cotransporter 2 inhibitors, *HEART failure patients, *DIURESIS, *VENTRICULAR ejection fraction
Abstract

Sodium-glucose cotransporter 2 inhibitors are believed to improve cardiac outcomes due to their osmotic diuretic potential. The goal of this study was to test the hypothesis that vasopressin-driven urine concentration overrides the osmotic diuretic effect of glucosuria induced by dapagliflozin treatment. DAPA-Shuttle1 (Hepato-renal Regulation of Water Conservation in Heart Failure Patients With SGLT-2 Inhibitor Treatment) was a single-center, double-blind, randomized, placebo-controlled trial, in which patients with chronic heart failure NYHA functional classes I/II and reduced ejection fraction were randomly assigned to receive dapagliflozin 10 mg daily or placebo (1:1) for 4 weeks. The primary endpoint was change from baseline in urine osmolyte concentration. Secondary endpoints included changes in copeptin levels and solute free water clearance. Thirty-three randomized, sodium-glucose cotransporter 2 inhibitor–naïve participants completed the study, 29 of whom (placebo: n = 14; dapagliflozin: n = 15) provided accurate 24-hour urine collections (mean age 59 ± 14 years; left ventricular ejection fraction 31% ± 9%). Dapagliflozin treatment led to an isolated increase in urine glucose excretion by 3.3 mmol/kg/d (95% CI: 2.51–4.04; P < 0.0001) within 48 hours (early) which persisted after 4 weeks (late; 2.7 mmol/kg/d [95% CI: 1.98–3.51]; P < 0.0001). Dapagliflozin treatment increased serum copeptin early (5.5 pmol/L [95% CI: 0.45-10.5]; P < 0.05) and late (7.8 pmol/L [95% CI: 2.77–12.81]; P < 0.01), leading to proportional reductions in free water clearance (early: −9.1 mL/kg/d [95% CI: −14 to −4.12; P < 0.001]; late: −11.0 mL/kg/d [95% CI: −15.94 to −6.07; P < 0.0001]) and elevated urine concentrations (late: 134 mmol/L [95% CI: 39.28–229.12]; P < 0.01). Therefore, urine volume did not significantly increase with dapagliflozin (mean difference early: 2.8 mL/kg/d [95% CI: −1.97 to 7.48; P = 0.25]; mean difference late: 0.9 mL/kg/d [95% CI: −3.83 to 5.62]; P = 0.70). Physiological-adaptive water conservation eliminated the expected osmotic diuretic potential of dapagliflozin and thereby prevented a glucose-driven increase in urine volume of approximately 10 mL/kg/d · 75 kg = 750 mL/kg/d. (Hepato-renal Regulation of Water Conservation in Heart Failure Patients With SGLT-2 Inhibitor Treatment [DAPA-Shuttle1]; NCT04080518). [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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