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265 results on '"Terao, Toshiki"'

1. Impact of donor type on the outcomes of acute graft versus host disease to systemic corticosteroid therapy

Author

Shimomura, Yoshimitsu, Kitamura, Tetsuhisa, Sugita, Junichi, Terao, Toshiki, Satake, Atsushi, Hirakawa, Tsuneaki, Uchida, Naoyuki, Shimabukuro, Masashi, Tanaka, Masatsugu, Eto, Tetsuya, Hiramoto, Nobuhiro, Kataoka, Keisuke, Nakamae, Hirohisa, Takase, Ken, Kawakita, Toshiro, Arai, Yasuyuki, Takeda, Wataru, Ishimaru, Fumihiko, Fukuda, Takahiro, Atsuta, Yoshiko, Nakasone, Hideki, and Kanda, Junya

Published
2024
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2. Association between human herpesvirus-6 encephalitis and antiviral prophylaxis after allogeneic hematopoietic stem cell transplantation in the letermovir era

Author

Terao, Toshiki, Matsuoka, Ken-ichi, Fuji, Shigeo, Kawamura, Shunto, Toya, Takashi, Doki, Noriko, Uchida, Naoyuki, Tanaka, Masatsugu, Fukuda, Takahiro, Sawa, Masashi, Ishikawa, Jun, Nishida, Tetsuya, Ohigashi, Hiroyuki, Maruyama, Yumiko, Fujiwara, Shin-ichiro, Kanda, Yoshinobu, Ota, Shuichi, Ishimaru, Fumihiko, Atsuta, Yoshiko, Kanda, Junya, Ogata, Masao, Yakushijin, Kimikazu, and Nakasone, Hideki

Published
2024
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10. A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling

Author

Abe, Yoshiaki, Sakata-Yanagimoto, Mamiko, Fujisawa, Manabu, Miyoshi, Hiroaki, Suehara, Yasuhito, Hattori, Keiichiro, Kusakabe, Manabu, Sakamoto, Tatsuhiro, Nishikii, Hidekazu, Nguyen, Tran B., Owada, Yohei, Enomoto, Tsuyoshi, Sawa, Aya, Bando, Hiroko, Yoshida, Chikashi, Tabata, Rikako, Terao, Toshiki, Nakayama, Masahiro, Ohshima, Koichi, Usuki, Kensuke, Oda, Tatsuya, Matsue, Kosei, and Chiba, Shigeru

Published
2022
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15. Combination of reduced post‐transplant cyclophosphamide and early tacrolimus initiation increases the incidence of chronic graft‐versus‐host disease in human leukocyte antigen‐haploidentical peripheral blood stem‐cell transplantation

Author

Terao, Toshiki, Kondo, Takumi, Nakamura, Makoto, Takasuka, Hiroki, Fujiwara, Hideaki, Asada, Noboru, Ennishi, Daisuke, Nishimori, Hisakazu, Fujii, Keiko, Fujii, Nobuharu, Maeda, Yoshinobu, and Matsuoka, Ken‐ichi

Published
2024
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21. 3D CNN-based Deep Learning Model-based Explanatory Prognostication in Patients  with Multiple Myeloma using Whole-body MRI.

Author

Morita, Kento, Karashima, Shigehiro, Terao, Toshiki, Yoshida, Kotaro, Yamashita, Takeshi, Yoroidaka, Takeshi, Tanabe, Mikoto, Imi, Tatsuya, Zaimoku, Yoshitaka, Yoshida, Akiyo, Maruyama, Hiroyuki, Iwaki, Noriko, Aoki, Go, Kotani, Takeharu, Murata, Ryoichi, Miyamoto, Toshihiro, Machida, Youichi, Matsue, Kosei, Nambo, Hidetaka, and Takamatsu, Hiroyuki

Subjects
MULTIPLE myeloma, STATISTICAL models, PREDICTIVE tests, THREE-dimensional imaging, RECEIVER operating characteristic curves, RESEARCH funding, HUMAN beings, MAGNETIC resonance imaging, RETROSPECTIVE studies, DESCRIPTIVE statistics, LONGITUDINAL method, KAPLAN-Meier estimator, LOG-rank test, DEEP learning, ARTIFICIAL neural networks, MEDICAL records, ACQUISITION of data, RESEARCH methodology, PROGRESSION-free survival, CONFIDENCE intervals, DATA analysis software, SENSITIVITY & specificity (Statistics), PROPORTIONAL hazards models
Abstract

Although magnetic resonance imaging (MRI) data of patients with multiple myeloma (MM) are used to predict prognosis, few reports have applied artificial intelligence (AI) techniques for this purpose. We aimed to analyze whole-body diffusion-weighted MRI data using three-dimensional (3D) convolutional neural networks (CNNs) and Gradient-weighted Class Activation Mapping (Grad-CAM), an explainable AI, to predict prognosis and explore the factors involved in prediction. We retrospectively analyzed the MRI data of a total of 142 patients with MM obtained from two medical centers. We defined the occurrence of progressive disease after MRI evaluation within 12 months as a poor prognosis and constructed a 3D CNN-based deep learning model to predict prognosis. Images from 111 cases were used as the training and internal validation data; images from 31 cases were used as the external validation data. Internal validation of the AI model with stratified 5-fold cross-validation resulted in a significant difference in progression-free survival (PFS) between good and poor prognostic cases (2-year PFS, 91.2% versus [vs.] 61.1%, P = 0.0002). The AI model clearly stratified good and poor prognostic cases in the external validation cohort (2-year PFS, 92.9% vs. 55.6%, P = 0.004), with an area under the receiver operating characteristic curve of 0.804. According to Grad-CAM, the MRI signals of the spleen and bones of the vertebrae and pelvis contributed to prognosis prediction. This study is the first to show that image analysis of whole-body MRI using a 3D CNN without any other clinical data is effective in predicting the prognosis of patients with MM. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Remission of hypersensitivity pneumonitis after allogeneic hematopoietic stem cell transplantation

Author

Inukai Motokura, Yumi, Higo, Hisao, Matsumoto, Chiaki, Uno, Mari, Fujiwara, Kanako, Terao, Toshiki, Makimoto, Satoko, Higaki, Fumiyo, Matsuoka, Ken-ichi, Tokioka, Fumiaki, Maeda, Yoshinobu, and Miyahara, Nobuaki

Abstract

A 50-year-old man was diagnosed with hypersensitivity pneumonitis caused by the environment of his bar owing to worsening symptoms, laboratory test results, and computed tomography images after an environmental inhalation challenge test. His hypersensitivity pneumonitis exacerbated despite receiving prednisolone 20 mg/day. The patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen-matched unrelated donor for myelodysplastic syndrome. No exacerbation of hypersensitivity pneumonitis was observed after HSCT. An environmental inhalation challenge test involving exposure to his bar confirmed the remission of hypersensitivity pneumonitis after HSCT. This case demonstrates that hypersensitivity pneumonitis can be remitted by HSCT.

Published
2024
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23. Multiple myeloma with t(11;14)-associated immature phenotype has lower CD38 expression and higher BCL2 dependence

Author

Kitadate, Akihiro, Terao, Toshiki, Narita, Kentaro, Ikeda, Sho, Takahashi, Yuto, Tsushima, Takafumi, Miura, Daisuke, Takeuchi, Masami, Takahashi, Naoto, Matsue, Kosei, Kitadate, Akihiro, Terao, Toshiki, Narita, Kentaro, Ikeda, Sho, Takahashi, Yuto, Tsushima, Takafumi, Miura, Daisuke, Takeuchi, Masami, Takahashi, Naoto, and Matsue, Kosei

Abstract

CD38 expression on myeloma cells is a critical factor affecting the early response to the anti-CD38 antibody daratumumab. However, factors affecting CD38 expression in untreated multiple myeloma are not fully elucidated. In this study, we found that CD38 expression was significantly lower in myeloma patients with the translocation t(11;14)-associated immature plasma cell phenotype, and particularly in those expressing B-cell-associated genes such as PAX5 and CD79A. CD138, a representative marker of plasmacytic differentiation, was also significantly lower in these patients, suggesting that CD38 expression may be associated with the differentiation and maturation stages of myeloma cells. Furthermore, the BCL2/BCL2L1 ratio, a response marker of the BCL2 inhibitor venetoclax, was significantly higher in patients with the immature phenotype expressing B-cell-associated genes. The BCL2/BCL2L1 ratio and CD38 expression were significantly negatively correlated. We also confirmed that patients with translocation t(11;14) expressing B-cell-associated genes were indeed less sensitive to daratumumab-mediated direct cytotoxicity but highly sensitive to venetoclax treatment in ex vivo assays. Moreover, all-trans-retinoic acid, which enhances CD38 expression and induces cell differentiation in myeloma cells, reduced B-cell marker expression and the BCL2/BCL2L1 ratio in myeloma cell lines, leading to reduced efficacy of venetoclax. Venetoclax specifically induces cell death in myeloma with t(11;14), although why patients with translocation t(11;14) show BCL2 dependence is unclear. These results suggest that BCL2 dependence, as well as CD38 expression, are deeply associated with the differentiation and maturation stages of myeloma cells. This study highlights the importance of examining t(11;14) and considering cell maturity in myeloma treatment strategies.

Published
2023

25. Early initiation of low-dose gilteritinib maintenance improves posttransplant outcomes in patients with R/R FLT3mut AML

Author

Terao, Toshiki, primary, Matsuoka, Ken-ichi, additional, Ueda, Hiroko, additional, Matsumura, Akifumi, additional, Matsubara, Chisato, additional, Kondo, Kaho, additional, Kondo, Takumi, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Fujii, Keiko, additional, Fujii, Nobuharu, additional, and Maeda, Yoshinobu, additional

Published
2022
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26. Impact of the Dose of Post-Transplant Cyclophosphamide and the Start Timing of Tacrolimus in Patients Who Received Allogeneic Stem-Cell Transplantation from Haploidentical Donor

Author

Terao, Toshiki, primary, Matsuoka, Ken-ichi, additional, Takasuka, Hiroki, additional, Kondo, Takumi, additional, Kamoi, Chihiro, additional, Ueda, Hiroko, additional, Matsumura, Akifumi, additional, Matsubara, Chisato, additional, Kondo, Kaho, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Fujii, Keiko, additional, Fujii, Nobuharu, additional, and Maeda, Yoshinobu, additional

Published
2022
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27. Prospective Study of the Usefulness of Liquid Biopsy in Patients with Unknown Fever Suspected of Malignant Lymphoma

Author

Okamoto, Akinao, primary, Sanada, Masashi, additional, Yasuda, Takahiko, additional, Kato, Seiichi, additional, Satou, Akira, additional, Matsue, Kosei, additional, Hosoi, Hiroki, additional, Yoshida, Masahiro, additional, Murakami, Satsuki, additional, Kondo, Eisei, additional, Masaki, Yasufumi, additional, Suzuki, Yasuhiro, additional, Miyazaki, Kana, additional, Kajiguchi, Tomohiro, additional, Hiraga, Junji, additional, Kurahashi, Shingo, additional, Inagaki, Yuichiro, additional, Ozeki, Kazutaka, additional, Saito, Shigeki, additional, Terao, Toshiki, additional, Iba, Sachiko, additional, Hattori, Keiko, additional, Yamamoto, Hideyuki, additional, Goto, Naoe, additional, Iriyama, Chisako, additional, Okamoto, Masataka, additional, and Tomita, Akihiro, additional

Published
2022
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28. Anti-Sars-Cov-2 Antibody and T-Cell Responses Using Deep T-Cell Receptor Immunosequencing after Vaccination Among Healthy Individuals and Patients with Multiple Myeloma or Lymphoma

Author

Takamatsu, Hiroyuki, primary, Ikeda, Daisuke, additional, Terao, Toshiki, additional, Yamashita, Takeshi, additional, Urushihara, Ryota, additional, Hatano, Yuzuki, additional, Hirose, Nana, additional, Yamada, Natsu, additional, Murata, Ryoichi, additional, Miyamoto, Toshihiro, additional, and Matsue, Kosei, additional

Published
2022
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29. Humoral Response to the Third-Dose COVID-19 Vaccination in Patients with Hematological Malignancy

Author

Ikeda, Daisuke, primary, Terao, Toshiki, additional, Fukumoto, Ami, additional, Kuzume, Ayumi, additional, Kamura, Yuya, additional, Tabata, Rikako, additional, Tsushima, Takafumi, additional, Miura, Daisuke, additional, Narita, Kentaro, additional, Takeuchi, Masami, additional, Yamashita, Takeshi, additional, Takamatsu, Hiroyuki, additional, and Matsue, Kosei, additional

Published
2022
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30. Gilteritinib Maintenance Therapy Post-Allogenic Stem-Cell Transplantation Improves the Prognosis of Patients with FLT3-Mutated AML

Author

Terao, Toshiki, primary, Matsuoka, Ken-ichi, additional, Ueda, Hiroko, additional, Matsumura, Akifumi, additional, Matsubara, Chisato, additional, Kondo, Kaho, additional, Kondo, Takumi, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Fujii, Keiko, additional, Fujii, Nobuharu, additional, and Maeda, Yoshinobu, additional

Published
2022
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31. Antibody status following booster vaccination against SARS‐CoV ‐2 virus in patients with haematologic malignancies

Author

Ikeda, Daisuke, primary, Terao, Toshiki, additional, Fukumoto, Ami, additional, Uesugi, Yuka, additional, Tabata, Rikako, additional, Kuzume, Ayumi, additional, Tsushima, Takafumi, additional, Miura, Daisuke, additional, Narita, Kentaro, additional, Takeuchi, Masami, additional, Yamashita, Takeshi, additional, Takamatsu, Hiroyuki, additional, and Matsue, Kosei, additional

Published
2022
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34. A Highly Conductive n-Type Coordination Complex with Thieno[3,2-b]thiophene Units: Facile Synthesis, Orientation, and Thermoelectric Properties

Author

Ueda, Kazuki, primary, Fukuzaki, Riku, additional, Ito, Takumu, additional, Toyama, Nana, additional, Muraoka, Masahiro, additional, Terao, Toshiki, additional, Manabe, Kei, additional, Hirai, Tomoyasu, additional, Wu, Ching-Ju, additional, Chuang, Shih-Ching, additional, Kawano, Shintaro, additional, and Murata, Michihisa, additional

Published
2022
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40. Impaired Antibody Response Following the Second Dose of the BNT162b2 Vaccine in Patients With Myeloproliferative Neoplasms Receiving Ruxolitinib

Author

Ikeda, Daisuke, primary, Terao, Toshiki, additional, Miura, Daisuke, additional, Narita, Kentaro, additional, Fukumoto, Ami, additional, Kuzume, Ayumi, additional, Kamura, Yuya, additional, Tabata, Rikako, additional, Tsushima, Takafumi, additional, Takeuchi, Masami, additional, Hosoki, Takaaki, additional, and Matsue, Kosei, additional

Published
2022
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41. Depletion of CD38 ‐positive regulatory T cells by anti‐CD38 monoclonal antibodies induces a durable response to SARS‐CoV ‐2 vaccination in patients with plasma cell dyscrasia

Author

Terao, Toshiki, primary, Naduka, Takashi, additional, Ikeda, Daisuke, additional, Fukumoto, Ami, additional, Kamura, Yuya, additional, Kuzume, Ayumi, additional, Tabata, Rikako, additional, Tsushima, Takafumi, additional, Miura, Daisuke, additional, Narita, Kentaro, additional, Takeuchi, Masami, additional, and Matsue, Kosei, additional

Published
2022
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43. Antibody status following booster vaccination against SARS‐CoV‐2 virus in patients with haematologic malignancies.

Author

Ikeda, Daisuke, Terao, Toshiki, Fukumoto, Ami, Uesugi, Yuka, Tabata, Rikako, Kuzume, Ayumi, Tsushima, Takafumi, Miura, Daisuke, Narita, Kentaro, Takeuchi, Masami, Yamashita, Takeshi, Takamatsu, Hiroyuki, and Matsue, Kosei

Subjects
*BOOSTER vaccines, *SARS-CoV-2, *ANTIBODY titer, *COVID-19 vaccines, *IMMUNOGLOBULIN G
Abstract

Summary: Antibody titres in 462 patients with haematological malignancies after the second (D2) and third (D3) SARS‐CoV‐2 vaccine were compared with those of healthy controls (HCs). Significant decay of antibody titre was observed pre D3, but titre surged post D3. The number of seronegative patients decreased from 79 (17.1%) to 44 (9.5%) from post D2 to post D3, and patients with adequate antibody titre increased from 204 (44.2%) to 358 (77.5%). Of the patients who received B‐cell‐targeted therapy, 80% were seronegative and 71% remained seronegative after D3. CD19+, CD4+, CD8+ cell counts, and immunoglobulin G (IgG) levels were identified as independent predictors for adequate serologic response. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Prognostic Relevance of Tumor-Infiltrating T-Lymphocytes on Total Metabolic Tumor Volume-Based Risk Stratification of Patients with Diffuse Large B-Cell Lymphoma

Author

Ikeda, Daisuke, primary, Narita, Kentaro, additional, Fukumoto, Ami, additional, Kuzume, Ayumi, additional, Kamura, Yuya, additional, Tabata, Rikako, additional, Terao, Toshiki, additional, Tsushima, Takafumi, additional, Miura, Daisuke, additional, Takeuchi, Masami, additional, Machida, Youichi, additional, and Matsue, Kosei, additional

Published
2021
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46. Loss of Spleen Visualization on Whole-Body Diffusion-Weighted Imaging in Patients with Multiple Myeloma Is Associated with Poor Prognosis and High Tumor Burden

Author

Terao, Toshiki, primary, Machida, Youichi, additional, Tateishi, Ukihide, additional, Tsushima, Takafumi, additional, Narita, Kentaro, additional, Ikeda, Daisuke, additional, Fukumoto, Ami, additional, Kuzume, Ayumi, additional, Tabata, Rikako, additional, Miura, Daisuke, additional, Takeuchi, Masami, additional, and Matsue, Kosei, additional

Published
2021
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50. Additional file 1 of Light chain deposition disease involving kidney and liver in a patient with IgD myeloma

Author

Tsushima, Takafumi, Suzuki, Tomo, Terao, Toshiki, Miura, Daisuke, Narita, Kentaro, Takeuchi, Masami, Shimuzu, Akira, and Kosei Matsue

Abstract

Additional file 1. Supplemental Fig. 1 Kidney biopsy specimen showed (a) mesangial nodular glomerulosclerosis and thickened glomerular basement membrane. Mesangiolysis with aneurysmal dilatation of capillary lumen (PAS). Immunohistochemistry showed (b) positive staining for Igκand (c) negative staining for Igλ. (d) Proximal tubular basement membrane was thickened and distal tubule was occupied with PAS positive cast which was (e) positive for Igκ and (f) negative for Igλ.

Published
2021
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