14 results on '"Tercan H"'
Search Results
2. Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity.
- Author
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Tercan, H. and Tercan, H.
- Subjects
- All institutes and research themes of the Radboud University Medical Center., Radboudumc 16: Vascular damage Internal Medicine., Radboudumc 4: lnfectious Diseases and Global Health Human Genetics., Radboudumc 4: lnfectious Diseases and Global Health Internal Medicine.
- Published
- 2024
Catalog
3. Interdisciplinary Data Driven Production Process Analysis for the Internet of Production
- Author
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Meyes, R., Tercan, H., Thiele, T., Krämer, A., Heinisch, J., Liebenberg, M., Hirt, G., Hopmann, Ch., Lakemeyer, G., Meisen, T., and Jeschke, S.
- Published
- 2018
- Full Text
- View/download PDF
4. Clonal hematopoiesis and trained immunity in individuals with obesity
- Author
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Tercan, H., primary, Bahrar, H., additional, Cossins, B., additional, Rutten, J., additional, Joosten, L., additional, Netea, M., additional, Hoischen, A., additional, Bekkering, S., additional, and Riksen, N., additional more...
- Published
- 2023
- Full Text
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5. Clonal hematopoiesis and inflammation in obesity
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Tercan, H., primary, Van Deuren, R.C., additional, Schraa, K., additional, Horst, R. Ter, additional, Van Den Munckhof, I.C., additional, Bekkering, S., additional, Rutten, J.H., additional, Netea, M.G., additional, Joosten, L.A.B., additional, Hoischen, A., additional, and Riksen, N.P., additional more...
- Published
- 2021
- Full Text
- View/download PDF
6. In vitro induction of trained immunity in adherent human monocytes
- Author
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Dominguez Andres, J., Arts, R.J.W., Bekkering, S., Bahrar, H., Blok, B.A., Bree, L.C.J. de, Bruno, M., Bulut, Ö, Debisarun, A., Dijkstra, H.I., Dos Santos, J.C., Ferreira, A.V., Flores Gomez, D., Groh, L.A., Grondman, I., Helder, L.S., Jacobs, C.W.M., Jacobs, L., Jansen, T.J., Kilic, G., Kluck, V., Koeken, V.A.C.M., Hak-Lemmers, H.L.M., Moorlag, S.J.C.F.M., Mourits, V.P., Puffelen, J.H. van, Rabold, K., Röring, R.J., Rosati, D., Tercan, H., Tuijl, J. van, Quintin, J., Crevel, R. van, Riksen, N.P., Joosten, L.A.B., Netea, M.G., Dominguez Andres, J., Arts, R.J.W., Bekkering, S., Bahrar, H., Blok, B.A., Bree, L.C.J. de, Bruno, M., Bulut, Ö, Debisarun, A., Dijkstra, H.I., Dos Santos, J.C., Ferreira, A.V., Flores Gomez, D., Groh, L.A., Grondman, I., Helder, L.S., Jacobs, C.W.M., Jacobs, L., Jansen, T.J., Kilic, G., Kluck, V., Koeken, V.A.C.M., Hak-Lemmers, H.L.M., Moorlag, S.J.C.F.M., Mourits, V.P., Puffelen, J.H. van, Rabold, K., Röring, R.J., Rosati, D., Tercan, H., Tuijl, J. van, Quintin, J., Crevel, R. van, Riksen, N.P., Joosten, L.A.B., and Netea, M.G. more...
- Abstract
Contains fulltext : 232459.pdf (Publisher’s version ) (Open Access), A growing number of studies show that innate immune cells can undergo functional reprogramming, facilitating a faster and enhanced response to heterologous secondary stimuli. This concept has been termed "trained immunity." We outline here a protocol to recapitulate this in vitro using adherent monocytes from consecutive isolation of peripheral blood mononuclear cells. The induction of trained immunity and the associated functional reprogramming of monocytes is described in detail using β-glucan (from Candida albicans) and Bacillus Calmette-Guérin as examples. For complete details on the use and execution of this protocol, please refer to Repnik et al. (2003) and Bekkering et al. (2016). more...
- Published
- 2021
7. Trained Immunity: Long-Term Adaptation in Innate Immune Responses
- Author
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Tercan, H., Riksen, N.P., Joosten, L.A.B., Netea, M.G., Bekkering, S., Tercan, H., Riksen, N.P., Joosten, L.A.B., Netea, M.G., and Bekkering, S.
- Abstract
Item does not contain fulltext, Adaptive immune responses are characterized by antigen specificity and induction of lifelong immunologic memory. Recently, it has been reported that innate immune cells can also build immune memory characteristics-a process termed trained immunity. Trained immunity describes the persistent hyperresponsive phenotype that innate immune cells can develop after brief stimulation. Pathogenic stimuli such as microorganisms, and also endogenous molecules including uric acid, oxidized LDL (low-density lipoprotein), and catecholamines, are capable of inducing memory in monocytes and macrophages. While trained immunity provides favorable cross-protection in the context of infectious diseases, the heightened immune response can be maladaptive in diseases driven by chronic systemic inflammation, such as atherosclerosis. Trained immunity is maintained by distinct epigenetic and metabolic mechanisms and persists for at least several months in vivo due to reprogramming of myeloid progenitor cells. Additionally, certain nonimmune cells are also found to exhibit trained immunity characteristics. Thus, trained immunity presents an exciting framework to develop new approaches to vaccination and also novel pharmacological targets in the treatment of inflammatory diseases. more...
- Published
- 2021
8. The Effect of Low-Dose Colchicine on the Phenotype and Function of Neutrophils and Monocytes in Patients with Chronic Coronary Artery Disease: A Double-Blind Randomized Placebo-Controlled Cross-Over Study.
- Author
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Tercan H, van Broekhoven A, Bahrar H, Opstal T, Cossins BC, Rother N, Rodwell L, Bekkering S, El Messaoudi S, Riksen NP, and Cornel JH
- Subjects
- Humans, Double-Blind Method, Male, Middle Aged, Female, Aged, Lipocalin-2 genetics, Lipocalin-2 metabolism, Chronic Disease, Colchicine pharmacology, Colchicine administration & dosage, Monocytes drug effects, Monocytes metabolism, Cross-Over Studies, Neutrophils drug effects, Neutrophils metabolism, Coronary Artery Disease drug therapy, Phenotype
- Abstract
Recent landmark trials showed that colchicine provides a substantial benefit in reducing major cardiovascular events in patients with coronary artery disease. Yet, its exact mechanism of action is still poorly understood. This study aimed to unravel the effect of colchicine on monocyte and neutrophil phenotype and function. A randomized double-blind placebo-controlled cross-over intervention study was executed in patients with a history of myocardial infarction. In neutrophils, colchicine treatment decreased CD62L expression and NGAL release upon ex vivo stimulation and increased PMA-induced ROS production. The effects of colchicine on monocytes were limited to a decrease in HLA-DR expression in the intermediate and nonclassical monocytes. Also, on the level of RNA expression, colchicine did not affect monocyte phenotype, while affecting various immunomodulating genes in neutrophils. Overall, our study suggests that treatment with colchicine affects neutrophil function, particularly by reducing neutrophil recruitment, lowering concentrations of NGAL, and changing the expression of various genes with immunomodulatory potential, whereas the effect on monocytes is limited., (© 2024 The Author(s). Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.) more...
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- 2024
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- View/download PDF
9. Clonal hematopoiesis is associated with cardiovascular events in patients with stable coronary artery disease.
- Author
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Dregoesc MI, Tercan H, Țigu AB, Bekkering S, Joosten LA, Netea MG, van Deuren RC, Hoischen A, Riksen NP, and Iancu AC
- Abstract
Clonal hematopoiesis (CH) is a risk factor for atherosclerotic cardiovascular disease, but the impact of smaller clones and the effect on inflammatory parameters is largely unknown. Using ultrasensitive single-molecule molecular inversion probe sequencing, we evaluated the association between CH and a first major adverse cardiovascular event (MACE) in patients with angiographically documented stable coronary artery disease (CAD) and no history of acute ischemic events. CH was associated with an increased rate of MACE at four years follow-up. The size of the clone predicted MACE at an optimal cut-off value of 1.07% variant allele frequency (VAF). Mutation carriers had no change in monocytes subsets or cytokine production capacity but had higher levels of circulating tissue factor, matrilysin, and proteinase-activated receptor-1. Our study identified CH driver mutations with a VAF as small as 1.07% as a residual cardiovascular risk factor and identified potential biomarkers and therapeutic targets for patients with stable CAD., Competing Interests: The authors declare no competing interests., (© 2024 The Authors.) more...
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- 2024
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10. Soluble urate-induced effects on cytokine production in vitro - Assessment of methodologies and cell types.
- Author
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Liu R, Klück V, Kischkel B, Tercan H, Netea MG, Crişan TO, and Joosten LAB
- Subjects
- Humans, Leukocytes, Mononuclear metabolism, Sodium Hydroxide metabolism, Sodium Hydroxide pharmacology, Monocytes, Inflammation Mediators metabolism, Uric Acid pharmacology, Uric Acid metabolism, Hyperuricemia metabolism
- Abstract
Background: Hyperuricemia has been shown to be an inducer of pro-inflammatory mediators by human primary monocytes. To study the deleterious effects of hyperuricemia, a reliable and stable in vitro model using soluble urate is needed. One recent report showed different urate-dissolving methods resulted in either pro-inflammatory or anti-inflammatory properties. The aim of this study was to compare the effect of two methods of dissolving urate on both primary human peripheral blood mononuclear cells (PBMCs) and THP-1 cells. The two methods tested were 'pre-warming' and 'dissolving with NaOH'., Methods: Primary human PBMCs and THP-1 cells were exposed to urate solutions, prepared using the two methodologies: pre-warming and dissolving with NaOH. Afterwards, cells were stimulated with various stimuli, followed by the measurement of the inflammatory mediators IL-1β, IL-6, IL-1Ra, TNF, IL-8, and MCP-1., Results: In PBMCs, we observed an overall pro-inflammatory effect of urate, both in the pre-warming and the NaOH dissolving method. A similar pro-inflammatory effect was seen in THP-1 cells for both dissolving methods after restimulation. However, THP-1 cells exhibited pro-inflammatory profile with exposure to urate alone without restimulation. We did not find MSU crystals in our cellular assays., Conclusions: Overall, the urate dissolving methods do not have critical impact on its inflammatory properties. Soluble urate prepared using either of the two methods showed mostly pro-inflammatory effects on human primary PBMCs and monocytic cell line THP-1. However, human primary PBMCs and the THP-1 differ in their response to soluble urate without restimulation., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Leo AB Joosten reports administrative support, article publishing charges, and equipment, drugs, or supplies were provided by Radboud University Nijmegen Medical Centre. Leo AB Joosten reports a relationship with Radboud University Nijmegen Medical Centre that includes: If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.) more...
- Published
- 2024
- Full Text
- View/download PDF
11. Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity.
- Author
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Tercan H, Cossins BC, van Deuren RC, Rutten JHW, Joosten LAB, Netea MG, Hoischen A, Bekkering S, and Riksen NP
- Subjects
- Male, Humans, Female, Middle Aged, Aged, Aged, 80 and over, Clonal Hematopoiesis, Leukocytes, Mononuclear metabolism, Cross-Sectional Studies, Overweight metabolism, Hematopoiesis genetics, Obesity complications, Obesity genetics, Inflammation metabolism, Interleukin-6 metabolism, Mutation, Metabolic Syndrome complications, Metabolic Syndrome genetics, Atherosclerosis metabolism
- Abstract
Background: Obesity is accompanied by dysregulated inflammation, which can contribute to vasculometabolic complications including metabolic syndrome and atherosclerosis. Recently, clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a risk factor for cardiovascular diseases. We aimed to determine how CHIP is related to immune cell function, systemic inflammation, and vasculometabolic complications in obese individuals., Methods and Results: Two hundred ninety-seven individuals with overweight and obesity, between the ages of 54 and 81 years, were recruited in a cross-sectional study. Clonal hematopoiesis driver mutations (CHDMs) were identified with an ultrasensitive targeted assay. Assessment of carotid artery atherosclerosis was performed with ultrasound. Detailed immunological parameters, including cytokine production capacity of peripheral blood mononuclear cells, and targeted plasma proteomics analysis, were studied. Adipose tissue inflammation was determined in subcutaneous fat biopsies. Individuals with CHIP had higher concentrations of circulating IL (interleukin)-6. Total number of leukocytes and neutrophils were higher in individuals with CHIP. In contrast, ex vivo cytokine production capacity of peripheral blood mononuclear cells was significantly lower in individuals with CHIP. Sex-stratified analysis showed that men with CHDMs had significantly higher leukocyte and neutrophil counts, and ex vivo cytokine production capacity was lower in women with CHDMs. Surprisingly, the presence of atherosclerotic plaques was significantly lower in individuals with CHDMs. There was no relation between CHIP and metabolic syndrome., Conclusions: In individuals with overweight or obesity, CHDMs are not associated with vasculometabolic complications, but rather with a lower presence of carotid plaques. CHDMs associate with increased circulating inflammatory markers and leukocyte numbers, but a lower peripheral blood mononuclear cell cytokine production capacity. more...
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- 2024
- Full Text
- View/download PDF
12. Exploring the link between Turkish gifted children's perceptions of the gifted label and emotional intelligence competencies.
- Author
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Tercan H and Bıçakçı MY
- Subjects
- Child, Emotional Intelligence, Emotions, Female, Humans, Male, Parents, Self Concept, Child, Gifted psychology
- Abstract
The present study attempts to explore the relation between Turkish gifted children's perceptions of the gifted label and their emotional intelligence competencies. We included 122 gifted children in this correlational study in the 2018-2019 academic year and collected the data using the Perceptions of Gifted Label Scale (PGLS) and the Emotional Intelligence Competencies Scale (EICS). In the analysis, we utilized descriptive statistics and calculated Pearson's correlation coefficients between the variables. The mean age of the children was 11.5 years, and there was an equal number of girls and boys. The findings revealed that the children got almost average scores on all subscales of the PGLS. The results uncovered that self-perception of the gifted label was significantly correlated with friends' and parents' perceptions of the gifted label [r = 0.380, p < .01]. We found a significant negative relationship between the PGLS self-perception and the EICS self-consciousness. To put it more clearly, as having increased self-consciousness, they are likely to have decreased perception of being labeled decreases. . Our findings also seem noteworthy in suggesting a helpful conceptual framework for designing therapeutic interventions for gifted children, who are often considered more sensitive to social-emotional issues., (© 2022. The Author(s).) more...
- Published
- 2022
- Full Text
- View/download PDF
13. In vitro induction of trained immunity in adherent human monocytes.
- Author
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Domínguez-Andrés J, Arts RJW, Bekkering S, Bahrar H, Blok BA, de Bree LCJ, Bruno M, Bulut Ö, Debisarun PA, Dijkstra H, Cristina Dos Santos J, Ferreira AV, Flores-Gomez D, Groh LA, Grondman I, Helder L, Jacobs C, Jacobs L, Jansen T, Kilic G, Klück V, Koeken VACM, Lemmers H, Moorlag SJCFM, Mourits VP, van Puffelen JH, Rabold K, Röring RJ, Rosati D, Tercan H, van Tuijl J, Quintin J, van Crevel R, Riksen NP, Joosten LAB, and Netea MG more...
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- Cellular Reprogramming physiology, Cytokines immunology, Humans, Leukocytes, Mononuclear cytology, Leukocytes, Mononuclear physiology, Monocytes physiology, Mycobacterium bovis physiology, beta-Glucans pharmacology, Cellular Reprogramming Techniques methods, Immunity, Innate immunology
- Abstract
A growing number of studies show that innate immune cells can undergo functional reprogramming, facilitating a faster and enhanced response to heterologous secondary stimuli. This concept has been termed "trained immunity." We outline here a protocol to recapitulate this in vitro using adherent monocytes from consecutive isolation of peripheral blood mononuclear cells. The induction of trained immunity and the associated functional reprogramming of monocytes is described in detail using β-glucan (from Candida albicans ) and Bacillus Calmette-Guérin as examples. For complete details on the use and execution of this protocol, please refer to Repnik et al. (2003) and Bekkering et al. (2016)., Competing Interests: The authors declare no competing interests, (© 2021 The Author(s).) more...
- Published
- 2021
- Full Text
- View/download PDF
14. Trained Immunity: Long-Term Adaptation in Innate Immune Responses.
- Author
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Tercan H, Riksen NP, Joosten LAB, Netea MG, and Bekkering S
- Subjects
- Animals, Communicable Diseases genetics, Communicable Diseases metabolism, Energy Metabolism, Epigenesis, Genetic, Hematopoietic Stem Cells metabolism, Host-Pathogen Interactions, Humans, Inflammation genetics, Inflammation metabolism, Inflammation Mediators immunology, Inflammation Mediators metabolism, Signal Transduction, Time Factors, Communicable Diseases immunology, Hematopoietic Stem Cells immunology, Immunity, Innate, Immunologic Memory, Inflammation immunology
- Abstract
Adaptive immune responses are characterized by antigen specificity and induction of lifelong immunologic memory. Recently, it has been reported that innate immune cells can also build immune memory characteristics-a process termed trained immunity. Trained immunity describes the persistent hyperresponsive phenotype that innate immune cells can develop after brief stimulation. Pathogenic stimuli such as microorganisms, and also endogenous molecules including uric acid, oxidized LDL (low-density lipoprotein), and catecholamines, are capable of inducing memory in monocytes and macrophages. While trained immunity provides favorable cross-protection in the context of infectious diseases, the heightened immune response can be maladaptive in diseases driven by chronic systemic inflammation, such as atherosclerosis. Trained immunity is maintained by distinct epigenetic and metabolic mechanisms and persists for at least several months in vivo due to reprogramming of myeloid progenitor cells. Additionally, certain nonimmune cells are also found to exhibit trained immunity characteristics. Thus, trained immunity presents an exciting framework to develop new approaches to vaccination and also novel pharmacological targets in the treatment of inflammatory diseases. more...
- Published
- 2021
- Full Text
- View/download PDF
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