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1. Treating Older Patients in Cardiogenic Shock With a Microaxial Flow Pump: Is it DANGERous?

Author

Møller, Jacob Eifer, Jensen, Lisette Okkels, Junker, Anders, Veien, Karsten Tange, Udesen, Nanna Louise Junker, Schmidt, Henrik, Hassager, Christian, Engstrøm, Thomas, Holmvang, Lene, Kjaergaard, Jesper, Sørensen, Rikke, Lønborg, Jacob, Frydland, Martin, Beske, Rasmus Paulin, Boesgaard, Søren, Eiskjær, Hans, Christensen, Steffen, Christiansen, Evald Høj, Terkelsen, Christian Juhl, Schäfer, Andreas, Linke, Axel, Woitek, Felix J., Hommel, Jennifer, Mangner, Norman, Polzin, Amin, Westenfeld, Ralf, Schulze, Christian, Moebius-Winkler, Sven, Skurk, Carsten, Nordbeck, Peter, Clemmensen, Peter, Westermann, Dirk, Panoulas, Vasileios, Zimmer, Sebastian, Werner, Nicos, Klein, Anika, Beske, Rasmus P., Jensen, Lisette O., Schulze, P. Christian, Werner, Nikos, Engstøm, Thomas, Terkelsen, Christian J., and Møller, Jacob E.

Published
2025
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5. Microaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial

Author

Zweck, Elric, Hassager, Christian, Beske, Rasmus P., Jensen, Lisette O., Eiskjær, Hans, Mangner, Norman, Polzin, Amin, Schulze, P. Christian, Skurk, Carsten, Nordbeck, Peter, Clemmensen, Peter, Panoulas, Vasileios, Zimmer, Sebastian, Schäfer, Andreas, Kelm, Malte, Engstrøm, Thomas, Holmvang, Lene, Junker, Anders, Schmidt, Henrik, Terkelsen, Christian J., Linke, Axel, Westenfeld, Ralf, Møller, Jacob E., Møller, Jacob Eifer, Jensen, Lisette Okkels, Junker, Anders, Veien, Karsten Tange, Udesen, Nanna Louise Junker, Ravn, Hanne Berg, Lassen, Jens Flensted, Wachtell, Kristian, Schmidt, Henrik, Hassager, Christian, Engstrøm, Thomas, Holmvang, Lene, Kjaergaard, Jesper, Sørensen, Rikke, Lønborg, Jacob, Fryldand, Martin, Beske, Rasmus Paulin, Boesgaard, Søren, Eiskjær, Hans, Christensen, Steffen, Christiansen, Evald Høj, Christensen, Steffen, Terkelsen, Christian Juhl, Schäfer, Andreas, Linke, Axel, Woitek, Felix J., Hommel, Jennifer, Mangner, Norman, Polzin, Amin, Westenfeld, Ralf, Schulze, Christian, Moebius-Winkler, Sven, Skurk, Carsten, Nordbeck, Peter, Clemmensen, Peter, Westermann, Dirk, Panoulas, Vasileios, Zimmer, Sebastian, Werner, Nikos, and De Haas, Inge

Published
2024
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8. Prospective study on the impact of different antithrombotic therapies on subclinical leaflet thickening and its temporal dynamics in transcatheter aortic valves—The NOTION-4 trial:Antithrombotic therapy and TAV-HALT

Author

Thuraiaiyah, Jani, Jørgensen, Troels Højsgaard, Jensen, Jesper Møller, Fuchs, Andreas, Willemen, Yannick, Terkelsen, Christian Juhl, Kofoed, Klaus Fuglsang, Søndergaard, Lars, Linde Nørgaard, Bjarne, De Backer, Ole, Thuraiaiyah, Jani, Jørgensen, Troels Højsgaard, Jensen, Jesper Møller, Fuchs, Andreas, Willemen, Yannick, Terkelsen, Christian Juhl, Kofoed, Klaus Fuglsang, Søndergaard, Lars, Linde Nørgaard, Bjarne, and De Backer, Ole

Abstract

Background Transcatheter aortic valve replacement (TAVR) has become the standard-of-care treatment for a majority of patients with severe, symptomatic aortic stenosis. The postprocedural antithrombotic therapeutic management is still a topic of debate and could affect the incidence of HALT, a phenomenon which can be assessed by 4-dimensional computed tomography (4DCT). Trial design The NOTION-4 trial is a randomized controlled trial comprising TAVR patients with no indication for oral anticoagulant (OAC) therapy, comparing lifelong single antiplatelet therapy (standard arm) versus early 3-month direct oral anticoagulant (DOAC) therapy followed by single antiplateletet therapy (experimental arm). The incidence of HALT and clinical endpoints will be evaluated in both groups at 3 months, 1 year and 5 years after randomization. The primary endpoint is the number of patients with at least 1 bioprosthetic aortic valve leaflet with HALT as assessed by cardiac 4DCT imaging at 1 year. The trial is powered for superiority testing and started enrollment in 2021. In total, 324 patients will be included. The last patient is expected to be enrolled by the end of 2024 and the primary endpoint is to be presented in 2026. Conclusion and perspective The NOTION-4 trial aims to study whether an early 3-month DOAC therapy after TAVR can result in a sustained lower incidence of HALT in transcatheter aortic valves. This trial holds the potential to give valuable insights into whether early OAC therapy should be integrated in future guidelines for post-TAVR antithrombotic therapeutic management., Background: Transcatheter aortic valve replacement (TAVR) has become the standard-of-care treatment for a majority of patients with severe, symptomatic aortic stenosis. The postprocedural antithrombotic therapeutic management is still a topic of debate and could affect the incidence of HALT, a phenomenon which can be assessed by 4-dimensional computed tomography (4DCT). Trial design: The NOTION-4 trial is a randomized controlled trial comprising TAVR patients with no indication for oral anticoagulant (OAC) therapy, comparing lifelong single antiplatelet therapy (standard arm) versus early 3-month direct oral anticoagulant (DOAC) therapy followed by single antiplateletet therapy (experimental arm). The incidence of HALT and clinical endpoints will be evaluated in both groups at 3 months, 1 year and 5 years after randomization. The primary endpoint is the number of patients with at least 1 bioprosthetic aortic valve leaflet with HALT as assessed by cardiac 4DCT imaging at 1 year. The trial is powered for superiority testing and started enrollment in 2021. In total, 324 patients will be included. The last patient is expected to be enrolled by the end of 2024 and the primary endpoint is to be presented in 2026. Conclusion and perspective: The NOTION-4 trial aims to study whether an early 3-month DOAC therapy after TAVR can result in a sustained lower incidence of HALT in transcatheter aortic valves. This trial holds the potential to give valuable insights into whether early OAC therapy should be integrated in future guidelines for post-TAVR antithrombotic therapeutic management. Trial registration: NOTION-4, ClinicalTrials.gov ID NCT06449469, https://clinicaltrials.gov/study/NCT06449469

Published
2025

11. International randomized trial on the effect of revascularization or optimal medical therapy of chronic total coronary occlusions with myocardial ischemia - ISCHEMIA-CTO trial – rationale and design

Author

Råmunddal, Truls, Holck, Emil Nielsen, Karim, Salma, Eftekhari, Ashkan, Escaned, Javier, Ioanes, Dan, Walsh, Simon, Spratt, James, Veien, Karsten, Jensen, Lisette Okkels, Tilsted, Hans-Henrik, Terkelsen, Christian Juhl, Havndrup, Ole, Olsen, Niels Thue, Kajander, Olli A., Faurie, Benjamin, Lanematt, Peep, Jakobsen, Lars, and Christiansen, Evald Høj

Published
2023
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12. Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation – the third nordic aortic valve intervention trial – NOTION-3

Author

Sabbah, Muhammad, Veien, Karsten, Niemela, Matti, Freeman, Phillip, Linder, Rickard, Ioanes, Dan, Terkelsen, Christian Juhl, Kajander, Olli A., Koul, Sasha, Savontaus, Mikko, Karjalainen, Pasi, Erglis, Andrejs, Minkkinen, Mikko, Jørgensen, Troels, Sondergaard, Lars, De Backer, Ole, Engstrøm, Thomas, and Lønborg, Jacob

Published
2023
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15. Use of Helicopters to Reduce Health Care System Delay in Patients With ST-Elevation Myocardial Infarction Admitted to an Invasive Center

Author

Mørk, Sivagowry Rasalingam, Bøtker, Morten Thingemann, Hjort, Jakob, Jensen, Lisette Okkels, Pedersen, Frants, Jørgensen, Gitte, Christensen, Erika Frischknect, Christensen, Marina Krintel, Aarø, Jens, Lippert, Freddy, Knudsen, Lars, Hansen, Troels Martin, Steinmetz, Jacob, and Terkelsen, Christian Juhl

Published
2022
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16. Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy

Author

Madsen, Jasmine Melissa, Glinge, Charlotte, Jabbari, Reza, Nepper-Christensen, Lars, Høfsten, Dan Eik, Tilsted, Hans-Henrik, Holmvang, Lene, Pedersen, Frants, Joshi, Francis Richard, Sørensen, Rikke, Bang, Lia Evi, Bøtker, Hans Erik, Terkelsen, Christian Juhl, Mæng, Michael, Jensen, Lisette Okkels, Aarøe, Jens, Kelbæk, Henning, Torp-Pedersen, Christian, Køber, Lars, Lønborg, Jacob Thomsen, and Engstrøm, Thomas

Published
2022
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18. Microaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic Shock: A Substudy of the DanGer Shock Randomized Clinical Trial

Author

Udesen, Nanna Louise Junker, Beske, Rasmus Paulin, Hassager, Christian, Jensen, Lisette Okkels, Eiskjær, Hans, Mangner, Norman, Polzin, Amin, Schulze, P. Christian, Skurk, Carsten, Nordbeck, Peter, Clemmensen, Peter, Panoulas, Vasileios, Zimmer, Sebastian, Schäfer, Andreas, Werner, Nikos, Frydland, Martin, Holmvang, Lene, Kjærgaard, Jesper, Engstøm, Thomas, Schmidt, Henrik, Junker, Anders, Terkelsen, Christian Juhl, Christensen, Steffen, Linke, Axel, and Møller, Jacob Eifer

Abstract

IMPORTANCE: Mechanical circulatory support with a microaxial flow pump (MAFP) has been shown to improve survival in ST-elevation myocardial infarction–induced cardiogenic shock (STEMI-CS). Understanding the impact on hemodynamic stability over time is crucial for optimizing patient treatment. OBJECTIVE: To determine if an MAFP reduces the need for pharmacological circulatory support without compromising hemodynamics compared with standard care in STEMI-CS. DESIGN, SETTING, AND PARTICIPANTS: This was a substudy of the Danish-German (DanGer) Shock trial, an international, multicenter, open-label randomized clinical trial. Patients from 14 heart centers across Denmark, Germany, and the UK were enrolled. Inclusion criteria for the trial were STEMI and systolic blood pressure less than 100 mm Hg or ongoing vasopressor treatment, left ventricular ejection fraction less than 45%, and arterial lactate level greater than 2.5 mmol/L. Of the enrolled patients, after exclusions from death in the catheterization laboratory or immediately on intensive care unit (ICU) admission, the remaining patients had serial recordings of hemodynamics, arterial lactate, and use of vasoactive drugs. Patients who were in comas after cardiac arrest and patients with mechanical complications or right ventricular failure were excluded. Data were analyzed from May to September 2024. INTERVENTIONS: MAFP and standard of care or standard of care alone. MAIN OUTCOMES AND MEASURES: Hemodynamic status in terms of heart rate and blood pressure, metabolic status in terms of arterial lactate concentration, and vasoactive-inotropic score (VIS). The clinical events during the first 72 hours were as follows: death from all causes, escalation of mechanical circulatory support, and discharge alive from the ICU. RESULTS: From 355 enrolled patients, 324 (mean [IQR] age, 68 [58-75] years; 259 male [80%]) underwent ICU treatment (169 [52%] in the MAFP group, 155 [48%] in the standard-care group). Baseline characteristics were balanced. There was no difference in heart rate between groups, and mean arterial pressure was above the treatment target of 65 mm Hg in both groups but was achieved with a lower VIS in the MAFP group. No difference in arterial lactate level was found between groups at randomization, but on arrival to the ICU, the MAFP group had significantly lower arterial lactate levels compared with the standard-care group (mean difference, 1.3 mmol/L; 95% CI, 0.7-1.9 mmol/L), a difference that persisted throughout the first 24 hours of observation. The MAFP group achieved lactate normalization (<2 mmol/L) 12 hours (95% CI, 5-18 hours) before the standard-care group. CONCLUSIONS AND RELEVANCE: Use of a MAFP reduces the use of vasopressors and inotropic medication while maintaining hemodynamic stability and achieving faster normalization of lactate level in patients with STEMI-CS. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01633502

Published
2025
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19. DANSPOT:A Multicenter Stepped-Wedge Cluster-Randomized Trial of the Reclassification of Acute Myocardial Infarction: Rationale and Study Design

Author

Strandkjær, Nina, Jørgensen, Nicoline, Hasselbalch, Rasmus Bo, Kristensen, Jonas, Knudsen, Marie Sophie Sander, Kock, Thilde Olivia, Lange, Theis, Lindholm, Matias Greve, Bruun, Niels Eske, Holmvang, Lene, Terkelsen, Christian Juhl, Pedersen, Claus Kjær, Christensen, Martin Kirk, Lassen, Jens Flensted, Hilsted, Linda, Ladefoged, Søren, Nybo, Mads, Bor, Mustafa Vakur, Dahl, Morten, Hansen, Annebirthe Bo, Kamstrup, Pia Rørbæk, Bundgaard, Henning, Torp-Pedersen, Christian, Iversen, Kasper Karmark, Strandkjær, Nina, Jørgensen, Nicoline, Hasselbalch, Rasmus Bo, Kristensen, Jonas, Knudsen, Marie Sophie Sander, Kock, Thilde Olivia, Lange, Theis, Lindholm, Matias Greve, Bruun, Niels Eske, Holmvang, Lene, Terkelsen, Christian Juhl, Pedersen, Claus Kjær, Christensen, Martin Kirk, Lassen, Jens Flensted, Hilsted, Linda, Ladefoged, Søren, Nybo, Mads, Bor, Mustafa Vakur, Dahl, Morten, Hansen, Annebirthe Bo, Kamstrup, Pia Rørbæk, Bundgaard, Henning, Torp-Pedersen, Christian, and Iversen, Kasper Karmark

Abstract

Background Cardiac troponins are the preferred biomarkers for the diagnosis of acute myocardial infarction. Although sex‐specific 99th percentile thresholds of troponins are recommended in international guidelines, the clinical effect of their use is poorly investigated. The DANSPOT Study (The Danish Study of Sex‐ and Population‐Specific 99th percentile upper reference limits of Troponin) aims to evaluate the clinical effect of a prospective implementation of population‐ and sex‐specific diagnostic thresholds of troponins into clinical practice. Methods This study is a nationwide, multicenter, stepped‐wedge cluster‐randomized trial of the implementation of population‐ and sex‐specific thresholds of troponins in 22 of 23 clinical centers in Denmark. We established sex‐specific thresholds for 5 different troponin assays based on troponin levels in a healthy Danish reference population. Centers will sequentially cross over from current uniform manufacturer‐derived thresholds to the new population‐ and sex‐specific thresholds. The primary cohort is defined as patients with symptoms suggestive of acute coronary syndrome having at least 1 troponin measurement performed within 24 hours of arrival with a peak troponin value between the current uniform threshold and the new sex‐specific female and male thresholds. The study will compare the occurrence of the primary outcome, defined as a composite of nonfatal myocardial infarction, unplanned revascularization, and all‐cause mortality within 1 year, separately for men and women before and after the implementation of the new sex‐specific thresholds. Conclusions The DANSPOT Study is expected to show the clinical effects on diagnostics, treatment, and clinical outcomes in patients with myocardial infarction of implementing sex‐specific diagnostic thresholds for troponin based on a national Danish reference population. Registration URL: https://www.clinicaltrials.gov; Unique identifier, BACKGROUND: Cardiac troponins are the preferred biomarkers for the diagnosis of acute myocardial infarction. Although sex-specific 99th percentile thresholds of troponins are recommended in international guidelines, the clinical effect of their use is poorly investigated. The DANSPOT Study (The Danish Study of Sex- and Population-Specific 99th percentile upper reference limits of Troponin) aims to evaluate the clinical effect of a prospective implementation of population- and sex-specific diagnostic thresholds of troponins into clinical practice. METHODS: This study is a nationwide, multicenter, stepped-wedge cluster-randomized trial of the implementation of population- and sex-specific thresholds of troponins in 22 of 23 clinical centers in Denmark. We established sex-specific thresholds for 5 different troponin assays based on troponin levels in a healthy Danish reference population. Centers will sequentially cross over from current uniform manufacturer-derived thresholds to the new population- and sex-specific thresholds. The primary cohort is defined as patients with symptoms suggestive of acute coronary syndrome having at least 1 troponin measurement performed within 24 hours of arrival with a peak troponin value between the current uniform threshold and the new sex-specific female and male thresholds. The study will compare the occurrence of the primary outcome, defined as a composite of nonfatal myocardial infarction, unplanned revascularization, and all-cause mortality within 1 year, separately for men and women before and after the implementation of the new sex-specific thresholds. CONCLUSIONS: The DANSPOT Study is expected to show the clinical effects on diagnostics, treatment, and clinical outcomes in patients with myocardial infarction of implementing sex-specific diagnostic thresholds for troponin based on a national Danish reference population. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05336435.

Published
2024

20. Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation:A Nationwide Register-Based Study

Author

Gregers, Emilie, Kragholm, Kristian, Linde, Louise, Mørk, Sivagowry Rasalingam, Andreasen, Jo Bønding, Terkelsen, Christian Juhl, Lassen, Jens Flensted, Møller, Jacob Eifer, Laugesen, Helle, Smerup, Morten, Kjærgaard, Jesper, Møller-Sørensen, Peter Hasse, Holmvang, Lene, Torp-Pedersen, Christian, Hassager, Christian, Søholm, Helle, Gregers, Emilie, Kragholm, Kristian, Linde, Louise, Mørk, Sivagowry Rasalingam, Andreasen, Jo Bønding, Terkelsen, Christian Juhl, Lassen, Jens Flensted, Møller, Jacob Eifer, Laugesen, Helle, Smerup, Morten, Kjærgaard, Jesper, Møller-Sørensen, Peter Hasse, Holmvang, Lene, Torp-Pedersen, Christian, Hassager, Christian, and Søholm, Helle

Abstract

Background Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory out‐of‐hospital cardiac arrest (OHCA). However, survivors managed with ECPR are at risk of poor functional status. The purpose of this study was to investigate return to work (RTW) after refractory OHCA. Methods and Results Of 44 360 patients with OHCA in the period of 2011 to 2020, this nationwide registry‐based study included 805 patients with refractory OHCA in the working age (18–65 years) who were employed before OHCA (2% of the total OHCA cohort). Demographics, prehospital characteristics, status at hospital arrival, employment status, and survival were retrieved through the Danish national registries. Sustainable RTW was defined as RTW for ≥6 months without any long sick leave relapses. Median follow‐up time was 4.1 years. ECPR and standard advanced cardiovascular life support were applied in 136 and 669 patients, respectively. RTW 1 year after OHCA was similar (39% versus 54%; P=0.2) and sustainable RTW was high in both survivors managed with ECPR and survivors managed with standard advanced cardiovascular life support (83% versus 85%; P>0.9). Younger age and shorter length of hospitalization were associated with RTW in multivariable Cox analysis, whereas ECPR was not. Conclusions In refractory OHCA‐patients employed prior to OHCA, approximately 1 out of 2 patients were employed after 1 year with no difference between patients treated with ECPR or standard advanced cardiovascular life support. Younger age and shorter length of hospitalization were associated with RTW while ECPR was not., BACKGROUND: Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory out-of-hospital cardiac arrest (OHCA). However, survivors managed with ECPR are at risk of poor functional status. The purpose of this study was to investigate return to work (RTW) after refractory OHCA.METHODS AND RESULTS: Of 44 360 patients with OHCA in the period of 2011 to 2020, this nationwide registry-based study included 805 patients with refractory OHCA in the working age (18-65 years) who were employed before OHCA (2% of the total OHCA cohort). Demographics, prehospital characteristics, status at hospital arrival, employment status, and survival were retrieved through the Danish national registries. Sustainable RTW was defined as RTW for ≥6 months without any long sick leave relapses. Median follow-up time was 4.1 years. ECPR and standard advanced cardiovascular life support were applied in 136 and 669 patients, respectively. RTW 1 year after OHCA was similar (39% versus 54%; P=0.2) and sustainable RTW was high in both survivors managed with ECPR and survivors managed with standard advanced cardiovascular life support (83% versus 85%; P>0.9). Younger age and shorter length of hospitalization were associated with RTW in multivariable Cox analysis, whereas ECPR was not.CONCLUSIONS: In refractory OHCA-patients employed prior to OHCA, approximately 1 out of 2 patients were employed after 1 year with no difference between patients treated with ECPR or standard advanced cardiovascular life support. Younger age and shorter length of hospitalization were associated with RTW while ECPR was not.

Published
2024

21. Lactate and lactate clearance as predictors of one-year survival in extracorporeal cardiopulmonary resuscitation – An international, multicentre cohort study

Author

Thevathasan, Tharusan, Gregers, Emilie, Mørk, Sivagowry Rasalingam, Degbeon, Sêhnou, Linde, Louise, Andreasen, Jo Bønding, Smerup, Morten, Møller, Jacob Eifer, Hassager, Christian, Laugesen, Helle, Dreger, Henryk, Brand, Anna, Balzer, Felix, Landmesser, Ulf, Terkelsen, Christian Juhl, Flensted Lassen, Jens, Skurk, Carsten, Søholm, Helle, Thevathasan, Tharusan, Gregers, Emilie, Mørk, Sivagowry Rasalingam, Degbeon, Sêhnou, Linde, Louise, Andreasen, Jo Bønding, Smerup, Morten, Møller, Jacob Eifer, Hassager, Christian, Laugesen, Helle, Dreger, Henryk, Brand, Anna, Balzer, Felix, Landmesser, Ulf, Terkelsen, Christian Juhl, Flensted Lassen, Jens, Skurk, Carsten, and Søholm, Helle

Abstract

Aim Extracorporeal cardiopulmonary resuscitation (ECPR) can be considered in selected patients with refractory cardiac arrest. Given the risk of patient futility and high resource utilisation, identifying ECPR candidates, who would benefit from this therapy, is crucial. Previous ECPR studies investigating lactate as a potential prognostic marker have been small and inconclusive. In this study, it was hypothesised that the lactate level (immediately prior to initiation of ECPR) and lactate clearance (within 24 hours after ECPR initiation) are predictors of one-year survival in a large, multicentre study cohort of ECPR patients. Methods Adult patients with refractory cardiac arrest at three German and four Danish tertiary cardiac care centres between 2011 and 2021 were included. Pre-ECPR lactate and 24-hour lactate clearance were divided into three equally sized tertiles. Multivariable logistic regression analyses and Kaplan-Meier analyses were used to analyse survival outcomes. Results 297 adult patients with refractory cardiac arrest were included in this study, of which 65 (22%) survived within one year. The pre-ECPR lactate level and 24-hour lactate clearance were level-dependently associated with one-year survival: OR 5.40 [95% CI 2.30–13.60] for lowest versus highest pre-ECPR lactate level and OR 0.25 [95% CI 0.09–0.68] for lowest versus highest 24-hour lactate clearance. Results were confirmed in Kaplan-Meier analyses (each p log rank < 0.001) and subgroup analyses. Conclusion Pre-ECPR lactate levels and 24 hour-lactate clearance after ECPR initiation in patients with refractory cardiac arrest were level-dependently associated with one-year survival. Lactate is an easily accessible and quickly available point-of-care measurement which might be considered as an early prognostic marker when considering initiation or continuation of ECPR treatment., Aim: Extracorporeal cardiopulmonary resuscitation (ECPR) can be considered in selected patients with refractory cardiac arrest. Given the risk of patient futility and high resource utilisation, identifying ECPR candidates, who would benefit from this therapy, is crucial. Previous ECPR studies investigating lactate as a potential prognostic marker have been small and inconclusive. In this study, it was hypothesised that the lactate level (immediately prior to initiation of ECPR) and lactate clearance (within 24 hours after ECPR initiation) are predictors of one-year survival in a large, multicentre study cohort of ECPR patients. Methods: Adult patients with refractory cardiac arrest at three German and four Danish tertiary cardiac care centres between 2011 and 2021 were included. Pre-ECPR lactate and 24-hour lactate clearance were divided into three equally sized tertiles. Multivariable logistic regression analyses and Kaplan-Meier analyses were used to analyse survival outcomes. Results: 297 adult patients with refractory cardiac arrest were included in this study, of which 65 (22%) survived within one year. The pre-ECPR lactate level and 24-hour lactate clearance were level-dependently associated with one-year survival: OR 5.40 [95% CI 2.30–13.60] for lowest versus highest pre-ECPR lactate level and OR 0.25 [95% CI 0.09–0.68] for lowest versus highest 24-hour lactate clearance. Results were confirmed in Kaplan-Meier analyses (each p log rank < 0.001) and subgroup analyses. Conclusion: Pre-ECPR lactate levels and 24 hour-lactate clearance after ECPR initiation in patients with refractory cardiac arrest were level-dependently associated with one-year survival. Lactate is an easily accessible and quickly available point-of-care measurement which might be considered as an early prognostic marker when considering initiation or continuation of ECPR treatment.

Published
2024

23. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial

Author

Junker, Anders, Kaltoft, Anne, Madsen, Morten, Christiansen, Evald Høj, Jakobsen, Lars, Carstensen, Steen, Kristensen, Steen Dalby, Thim, Troels, Pedersen, Karin Møller, Korsgaard, Mette Tidemand, Iversen, Allan, Jørgensen, Erik, Joshi, Francis, Pedersen, Frants, Tilsted, Hans Henrik, Alzuhairi, Karam, Saunamäki, Kari, Holmvang, Lene, Ahlehof, Ole, Sørensen, Rikke, Helqvist, Steffen, Mark, Bettina Løjmand, Villadsen, Anton Boel, Raungaard, Bent, Thuesen, Leif, Christiansen, Martin Kirk, Freeman, Philip, Jensen, Svend Eggert, Skov, Charlotte Schmidt, Aziz, Ahmed, Hansen, Henrik Steen, Ellert, Julia, Veien, Karsten, Pedersen, Knud Erik, Hansen, Knud Nørregård, Ahlehoff, Ole, Cappelen, Helle, Wittrock, Daniel, Hansen, Poul Anders, Ankersen, Jens Peter, Hedegaard, Kim Witting, Kempel, John, Kaus, Henning, Erntgaard, Dennis, Pedersen, Danny Mejsner, Giebner, Matthias, Hansen, Troels Martin Hansen, Radosavljevic-Radovanovic, Mina, Prodanovic, Maja, Savic, Lidija, Pejic, Marijana, Matic, Dragan, Uscumlic, Ana, Subotic, Ida, Lasica, Ratko, Vukcevic, Vladan, Suárez, Alfonso, Samaniego, Beatriz, Morís, César, Segovia, Eduardo, Hernández, Ernesto, Lozano, Iñigo, Pascual, Isaac, Vegas-Valle, Jose M., Rozado, José, Rondán, Juan, Avanzas, Pablo, del Valle, Raquel, Padrón, Remigio, García-Castro, Alfonso, Arango, Amalia, Medina-Cameán, Ana B., Fente, Ana I., Muriel-Velasco, Ana, Pomar-Amillo, Ángeles, Roza, César L., Martínez-Fernández, César M., Buelga-Díaz, Covadonga, Fernández-Gonzalo, David, Fernández, Elena, Díaz-González, Eloy, Martinez-González, Eugenio, Iglesias-Llaca, Fernando, Viribay, Fernando M., Fernández-Mallo, Francisco J., Hermosa, Francisco J., Martínez-Bastida, Ginés, Goitia-Martín, Javier, Vega-Fernández, José L., Tresguerres, Jose M., Rodil-Díaz, Juan A., Villar-Fernández, Lara, Alberdi, Lucía, Abella-Ovalle, Luis, de la Roz, Manuel, Fernández-Carral, Marcos Fernández-Carral, Naves, María C., Peláez, María C., Fuentes, María D., García-Alonso, María, Villanueva, María J., Vinagrero, María S., Vázquez-Suárez, María, Martínez-Valle, Marta, Nonide, Marta, Pozo-López, Mónica, Bernardo-Alba, Pablo, Galván-Núñez, Pablo, Martínez-Pérez, Polácido J., Castro, Rafael, Suárez-Coto, Raquel, Suárez-Noriega, Raquel, Guinea, Rocío, Quintana, Rosa B., de Cima, Sara, Hedrera, Segundo A., Laca, Sonia I., Llorente-Álvarez, Susana, Pascual, Susana, Cimas, Teodorna, Mathur, Anthony, McFarlane-Henry, Eleanor, Leonard, Gerry, Veerapen, Jessry, Westwood, Mark, Colicchia, Martina, Prossora, Mary, Andiapen, Mervyn, Mohiddin, Saidi, Lenzi, Valentina, Chong, Jun, Francis, Rohin, Pine, Amy, Jamieson-Leadbitter, Caroline, Neal, Debbie, Din, J., McLeod, Jane, Roberts, Josh, Polokova, Karin, Longman, Kristel, Penney, Lucy, Lakeman, Nicki, Wells, Nicki, Hopper, Oliver, Coward, Paul, O'Kane, Peter, Harkins, Ruth, Guyatt, Samantha, Kennard, Sarah, Orr, Sarah, Horler, Stephanie, Morris, Steve, Walvin, Tom, Snow, Tom, Cunnington, Michael, Burd, Amanda, Gowing, Anne, Krishnamurthy, Arvindra, Harland, Charlotte, Norfolk, Derek, Johnstone, Donna, Newman, Hannah, Reed, Helen, O'Neill, James, Greenwood, John, Cuxton, Josephine, Corrigan, Julie, Somers, Kathryn, Anderson, Michelle, Burtonwood, Natalie, Bijsterveld, Petra, Brogan, Richard, Ryan, Tony, Kodoth, Vivek, Khan, Arif, Sebastian, Deepti, Gorog, Diana, Boyle, Georgina, Shepherd, Lucy, Hamid, Mahmood, Farag, Mohamed, Spinthakis, Nicholas, Waitrak, Paulina, De Sousa, Phillipa, Bhatti, Rishma, Oliver, Victoria, Walshe, Siobhan, Odedra, Toral, Gue, Ying, Kanji, Rahim, Ryding, Alisdair, Ratcliffe, Amanda, Merrick, Angela, Horwood, Carol, Sarti, Charlotte, Maart, Clint, Moore, Donna, Dockerty, Francesca, Baucutt, Karen, Pitcher, Louise, Ilsley, Mary, Clarke, Millie, Germon, Rachel, Gomes, Sara, Clare, Thomas, Nair, Sunil, Staines, Jocasta, Nicholson, Susan, Watkinson, Oliver, Gallagher, Ian, Nelthorpe, Faye, Musselwhite, Janine, Grosser, Konrad, Stimson, Leah, Eaton, Michelle, Heppell, Richard, Turney, Sharon, Horner, Victoria, Schumacher, Natasha, Moon, Angela, Mota, Paula, O'Donnell, Joshua, Panicker, Abeesh Sadasiva, Musa, Anntoniette, Tapp, Luke, Krishnamoorthy, Suresh, Ansell, Valerie, Ali, Danish, Hyndman, Samantha, Banerjee, Prithwish, Been, Martin, Mackenzie, Ailie, McGregor, Andrew, Hildick-Smith, David, Champney, Felicity, Ingoldby, Fiona, Keate, Kirstie, Bennett, Lorraine, Skipper, Nicola, Gregory, Sally, Harfield, Scott, Mudd, Alexandra, Wragg, Christopher, Barmby, David, Grech, Ever, Hall, Ian, Middle, Janet, Barker, Joann, Fofie, Joyce, Gunn, Julian, Housley, Kay, Cockayne, Laura, Weatherlley, Louise, Theodorou, Nana, Wheeldon, Nigel, Fati, Pene, Storey, Robert F., Richardson, James, Iqbal, Javid, Adam, Zul, Brett, Sarah, Agyemang, Michael, Tawiah, Cecilia, Hogrefe, Kai, Raju, Prashanth, Braybrook, Christine, Gracey, Jay, Waldron, Molly, Holloway, Rachael, Burunsuzoglu, Senem, Sidgwick, Sian, Hetherington, Simon, Beirnes, Charmaine, Fernandez, Olga, Lazar, Nicoleta, Knighton, Abigail, Rai, Amrit, Hoare, Amy, Webb, Ian, Breeze, Jonathan, Martin, Katherine, Andrews, Michelle, Patale, Sheetal, Bennett, Amy, Smallwood, Andrew, Radford, Elizabeth, Cotton, James, Martins, Joe, Wallace, Lauren, Milgate, Sarah, Munir, Shahzad, Metherell, Stella, Cottam, Victoria, Massey, Ian, Copestick, Jane, Delaney, Jane, Wain, Jill, Sandhu, Kully, Emery, Lisa, Butler, Robert, Hall, Charlotte, Bucciarelli-Ducci, Chiara, Besana, Rissa, Hussein, Jodie, Bell, Sheila, Gill, Abby, Bales, Emily, Polwarth, Gary, East, Clare, Smith, Ian, Oliveira, Joana, Victor, Saji, Woods, Sarah, Hoole, Stephen, Ramos, Angelo, Sevillano, Annaliza, Nicholson, Anne, Solieri, Ashley, Redman, Emily, Byrne, Jean, Joyce, Joan, Riches, Joanne, Davies, John, Allen, Kezia, Saclot, Louie, Ocampo, Madelaine, Vertue, Mark, Christmas, Natasha, Koothoor, Raiji, Gamma, Reto, Alvares, Wilson, Pepper, Stacey, Kobson, Barbara, Reeve, Christy, Malik, Iqbal, Chester, Emma, Saunders, Heidi, Mojela, Idah, Smee, Joanna, Davies, Justin, Davies, Nina, Clifford, Piers, Dias, Priyanthi, Kaur, Ramandeep, Moreira, Silvia, Ahmad, Yousif, Tomlinson, Lucy, Pengelley, Clare, Bidle, Amanda, Spence, Sharon, Al-Lamee, Rasha, Phuyal, Urmila, Abbass, Hakam, Bose, Tuhina, Elliott, Rebecca, Foundun, Aboo, Chung, Alan, Freestone, Beth, Lee, Dr Kaeng, Elshiekh, Dr Mohamed, Pulikal, George, Bhatre, Gurbir, Douglas, James, Kaeng, Lee, Pitt, Mike, Watkins, Richard, Gill, Simrat, Hartley, Amy, Lucking, Andrew, Moreby, Berni, Darby, Damaris, Corps, Ellie, Parsons, Georgina, De Mance, Gianluigi, Fahrai, Gregor, Turner, Jenny, Langrish, Jeremy, Gaughran, Lisa, Wolyrum, Mathias, Azkhalil, Mohammed, Bates, Rachel, Given, Rachel, Kharbanda, Rajesh, Douthwaite, Rebecca, Lloyd, Steph, Neubauer, Stephen, Barker, Deborah, Dana, Ali, Suttling, Anne, Turner, Charlotte, Smith, Clare, Longbottom, Colin, Ross, David, Cunliffe, Denise, Cox, Emily, Whitehead, Helena, Hudson, Karen, Jones, Leslie, Drew, Martin, Chant, Nicholas, Haworth, Peter, Capel, Robert, Austin, Rosalynn, Howe, Serena, Smith, Trevor, Hobson, Alex, Strike, Philip, Griffiths, Huw, Anantharam, Brijesh, Jack, Pearse, Thornton, Emma, Hodgson, Adrian, Jennison, Alan, McSkeane, Anna, Smith, Bethany, Shaw, Caroline, Leathers, Chris, Armstrong, Elissa, Carruthers, Gayle, Simpson, Holly, Smith, Jan, Hodierne, Jeremy, Kelly, Julie, Barclay, Justin, Scott, Kerry, Gregson, Lisa, Buchanan, Louise, McCormick, Louise, Varma, Madhusudhan, Kelsall, Nicci, Mcarthy, Rachel, Taylor, Rebecca, Thompson, Rebecca, Shelton, Rhidian, Moore, Roger, Tomlinson, Sharon, Thambi, Sunil, Cooper, Theresa, Oakes, Trevor, Deen, Zakhira, Relph, Chris, prentice, Scott, Hall, Lorna, Dillon, Angela, Meadows, Deborah, Frank, Emma, Markham-Jones, Helene, Thomas, Isobel, Gale, Joanne, Denman, Joanne, O'Connor, John, Hindle, Julia, Jackson-Lawrence, Karen, Warner, Karen, Lee, Kelvin, Upton, Robert, Elston, Ruth, Lee, Sandra, Venugopal, Vinod, Finch, Amanda, Fleming, Catherine, Whiteside, Charlene, Pemberton, Chris, Wilkinson, Conor, Sebastian, Deepa, Riedel, Ella, Giuffrida, Gaia, Burnett, Gillian, Spickett, Helen, Glen, James, Brown, Janette, Thornborough, Lauren, Pedley, Lauren, Morgan, Maureen, Waddington, Natalia, Brennan, Oliver, More, Ranjit, Brady, Rebecca, Preston, Stephen, Loder, Chris, Vlad, Ionela, Laurence, Julia, Smit, Angelique, Dimond, Kirsty, Hayes, Michelle, Paddy, Loveth, Crause, Jacolene, Amed, Nadifa, Kaur-Babooa, Priya, Rakhit, Roby, Kotecha, Tushar, Fayed, Hossam, Pavlidis, Antonis, Prendergast, Bernard, Clapp, Brian, Perara, Divaka, Atkinson, Emma, Ellis, Howard, Wilson, Karen, Gibson, Kirsty, Smith, Megan, Khawaja, Muhammed Zeeshan, Sanchez-Vidal, Ruth, Redwood, Simon, Jones, Sophie, Tipping, Aoife, Oommen, Anu, Hendry, Cara, Fath-Orboubadi, DR Fazin, Phillips, Hannah, Kolakaluri, Laurel, Sherwood, Martin, Mackie, Sarah, Aleti, Shilpa, Charles, Thabitha, Roy, Liby, Henderson, Rob, Stables, Rod, Marber, Michael, Berry, Alan, Redington, Andrew, Thygesen, Kristian, Andersen, Henning Rud, Berry, Colin, Copas, Andrew, Meade, Tom, Kelbæk, Henning, Bueno, Hector, von Weitzel-Mudersbach, Paul, Andersen, Grethe, Ludman, Andrew, Cruden, Nick, Topic, Dragan, Mehmedbegovic, Zlatko, de la Hera Galarza, Jesus Maria, Robertson, Steven, Van Dyck, Laura, Chu, Rebecca, Astarci, Josenir, Jamal, Zahra, Hetherington, Daniel, Collier, Lucy, Hausenloy, Derek J, Kharbanda, Rajesh K, Møller, Ulla Kristine, Ramlall, Manish, Aarøe, Jens, Bulluck, Heerajnarain, Clayton, Tim, Dodd, Matthew, Engstrom, Thomas, Evans, Richard, Lassen, Jens Flensted, Christensen, Erika Frischknecht, Garcia-Ruiz, José Manuel, Gorog, Diana A, Hjort, Jakob, Houghton, Richard F, Ibanez, Borja, Knight, Rosemary, Lippert, Freddy K, Lønborg, Jacob T, Maeng, Michael, Milasinovic, Dejan, Nicholas, Jennifer M, Jensen, Lisette Okkels, Perkins, Alexander, Radovanovic, Nebojsa, Rakhit, Roby D, Ravkilde, Jan, Ryding, Alisdair D, Schmidt, Michael R, Riddervold, Ingunn Skogstad, Sørensen, Henrik Toft, Stankovic, Goran, Terkelsen, Christian Juhl, Greenwood, John P, Yellon, Derek M, and Bøtker, Hans Erik

Published
2019
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24. Unreported exclusion and sampling bias in interpretation of randomized controlled trials in patients with STEMI

Author

Laursen, Peter Nørkjær, Holmvang, Lene, Lønborg, Jacob, Køber, Lars, Høfsten, Dan E., Helqvist, Steffen, Clemmensen, Peter, Kelbæk, Henning, Jørgensen, Erik, Lassen, Jens Flensted, Pedersen, Frants, Høi-Hansen, Thomas, Raungaard, Bent, Terkelsen, Christian Juhl, Jensen, Lisette Okkels, Sadjadieh, Golnaz, and Engstrøm, Thomas

Published
2019
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26. Everolimus-Eluting Versus Biolimus-Eluting Stents With Biodegradable Polymers in Unselected Patients Undergoing Percutaneous Coronary Intervention: A Randomized Noninferiority Trial With 1-Year Follow-Up (SORT OUT VIII Trial)

Author

Maeng, Michael, Bøtker, Hans Erik, Christiansen, Evald Høj, Raungaard, Bent, Jensen, Svend Eggert, Hansen, Henrik Steen, Jensen, Lisette Okkels, Bargsteen, Helle, Pedersen, Helle, Jørgensen, Lars P., Ottosen, Pia, Pedersen, Karin M., Thygesen, Kristian, Sørensen, Jacob Thorsted, Andersen, Henning Rud, Kahlert, Johnny, Terkelsen, Christian Juhl, Kristensen, Steen Dalby, Carstensen, Steen, Aarøe, Jens, Villadsen, Anton Boel, Lassen, Jens Flensted, Thim, Troels, Eftekhari, Ashkan, Veien, Karsten Tange, Hansen, Knud Nørregaard, and Junker, Anders

Published
2019
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27. Mechanical circulatory support for refractory out-of-hospital cardiac arrest: a Danish nationwide multicenter study

Author

Mørk, Sivagowry Rasalingam, Stengaard, Carsten, Linde, Louise, Møller, Jacob Eifer, Jensen, Lisette Okkels, Schmidt, Henrik, Riber, Lars Peter, Andreasen, Jo Bønding, Thomassen, Sisse Anette, Laugesen, Helle, Freeman, Phillip Michael, Christensen, Steffen, Greisen, Jacob Raben, Tang, Mariann, Møller-Sørensen, Peter Hasse, Holmvang, Lene, Gregers, Emilie, Kjaergaard, Jesper, Hassager, Christian, Eiskjær, Hans, and Terkelsen, Christian Juhl

Published
2021
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30. Relation of Bleeding Events to Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated by Percutaneous Coronary Intervention (a DANAMI-3 Substudy)

Author

Sadjadieh, Golnaz, Engstrøm, Thomas, Helqvist, Steffen, Høfsten, Dan Eik, Køber, Lars, Pedersen, Frants, Laursen, Peter Nørkjær, Nepper-Christensen, Lars, Clemmensen, Peter, Møller-Helgestad, Ole Kristian, Sørensen, Rikke, Ravkilde, Jan, Terkelsen, Christian Juhl, Jørgensen, Erik, Saunamäki, Kari, Tilsted, Hans-Henrik, Kelbæk, Henning, and Holmvang, Lene

Published
2018
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32. Long‐term outcomes after coronary intervention with biodegradable polymer stents in patients with acute coronary syndromes

Author

Noori, Manijeh, primary, Christiansen, Evald Høj, additional, Raungaard, Bent, additional, Junker, Anders, additional, Christensen, Martin Kirk, additional, Kahlert, Johnny, additional, Maeng, Michael, additional, Freeman, Phillip, additional, Hansen, Kirstine Nørregaard, additional, Terkelsen, Christian Juhl, additional, Ellert‐Gregersen, Julia, additional, Kristensen, Steen Dalby, additional, Veien, Karsten Tange, additional, Jakobsen, Lars, additional, and Jensen, Lisette Okkels, additional

Published
2023
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33. 393 Why do patients develop in-hospital cardiac arrest? A prospective, single-center observational study of in-hospital cardiac arrest aetiologies (WHY-IHCA) - preliminary results in non-survivor cases

Author

Lind, Peter Carøe, primary, Al-Mashhadi, Rozh, additional, Nielsen, Tomas Frahm, additional, Bro-Jeppesen, John, additional, Terkelsen, Christian Juhl, additional, Boel, Lene Warner Thorup, additional, Andersen, Lars Wiuff, additional, and Granfeldt, Asger, additional

Published
2023
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38. Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register-Based Study.

Author

Gregers, Emilie, Kragholm, Kristian, Linde, Louise, Mørk, Sivagowry Rasalingam, Andreasen, Jo Bønding, Terkelsen, Christian Juhl, Lassen, Jens Flensted, Møller, Jacob Eifer, Laugesen, Helle, Smerup, Morten, Kjærgaard, Jesper, Møller-Sørensen, Peter Hasse, Holmvang, Lene, Torp-Pedersen, Christian, Hassager, Christian, and Søholm, Helle

Published
2024
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40. Randomized Comparison of the Polymer-Free Biolimus-Coated BioFreedom Stent With the Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Orsiro Stent in an All-Comers Population Treated With Percutaneous Coronary Intervention: The SORT OUT IX Trial

Author

Jensen, Lisette Okkels, Maeng, Michael, Raungaard, Bent, Kahlert, Johnny, Ellert, Julia, Jakobsen, Lars, Villadsen, Anton Boel, Veien, Karsten Tange, Kristensen, Steen Dalby, Ahlehoff, Ole, Carstensen, Steen, Christensen, Martin Kirk, Terkelsen, Christian Juhl, Engstroem, Thomas, Hansen, Knud Nørregaard, Bøtker, Hans Erik, Aaroe, Jens, Thim, Troels, Thuesen, Leif, Freeman, Philip, Aziz, Ahmed, Eftekhari, Ashkan, Junker, Anders, Jensen, Svend Eggert, Lassen, Jens Flensted, Hansen, Henrik Steen, and Christiansen, Evald Høj

Published
2020
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42. Comparison of Outcome of Patients With ST-Segment Elevation Myocardial Infarction and Complete Versus Incomplete ST-Resolution Before Primary Percutaneous Coronary Intervention

Author

Lønborg, Jacob, Kelbæk, Henning, Holmvang, Lene, Helqvist, Steffen, Vejlstrup, Niels, Jørgensen, Erik, Saunamäki, Kari, Dridi, Nadia P., Kløvgaard, Lene, Kaltoft, Anne, Bøtker, Hans-Erik, Lassen, Jens F., Clemmensen, Peter, Terkelsen, Christian Juhl, and Engstrøm, Thomas

Published
2016
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45. Clinical outcomes of the ACURATE neo2 transcatheter heart valve:a prospective, multicentre, observational, post-market surveillance study

Author

Kim, Won-Keun, Tamburino, Corrado, Möllmann, Helge, Montorfano, Matteo, Ellert-Gregersen, Julia, Rudolph, Tanja K., Van Mieghem, Nicolas M., Hilker, Michael, Amat-Santos, Ignacio J., Terkelsen, Christian Juhl, Petronio, Anna Sonia, Stella, Pieter R., Götberg, Matthias, Rück, Andreas, Kasel, A. Markus, Trillo, Ramiro, Appleby, Clare, Barbanti, Marco, Blanke, Philipp, Modolo, Rodrigo, Allocco, Dominic J., Sondergaard, Lars, Kim, Won-Keun, Tamburino, Corrado, Möllmann, Helge, Montorfano, Matteo, Ellert-Gregersen, Julia, Rudolph, Tanja K., Van Mieghem, Nicolas M., Hilker, Michael, Amat-Santos, Ignacio J., Terkelsen, Christian Juhl, Petronio, Anna Sonia, Stella, Pieter R., Götberg, Matthias, Rück, Andreas, Kasel, A. Markus, Trillo, Ramiro, Appleby, Clare, Barbanti, Marco, Blanke, Philipp, Modolo, Rodrigo, Allocco, Dominic J., and Sondergaard, Lars

Abstract

BACKGROUND: The next-generation ACURATE neo2 transcatheter aortic valve was designed for simplified implantation and to mitigate the risk of paravalvular leak (PVL) compared to the earlier device.AIMS: To collect clinical outcomes and device performance data, including echocardiography and 4-dimensional computed tomography (4D-CT) data, with the ACURATE neo2 transcatheter heart valve in patients with severe aortic stenosis (AS).METHODS: ACURATE neo2 PMCF is a single-arm, multicentre study of patients with severe AS treated in routine clinical practice. The primary safety endpoint was all-cause mortality at 30-days. The primary imaging endpoint was hypo-attenuated leaflet thickening (HALT), measured by core laboratory-adjudicated 4D-CT at 30 days. Secondary endpoints included VARC safety endpoints, procedural success, and evaluation of valve performance via core laboratory-adjudicated echocardiography.RESULTS: The study enrolled 250 patients at 18 European centres (mean age: 80.8 years; 63.6% female; mean STS score: 2.9±2.0%); 246 (98.4%) were successfully treated with ACURATE neo2. The 30-day rates for mortality and disabling stroke were 0.8% and 0%, respectively. The new permanent pacemaker implantation rate was 6.5%. HALT >50% was present in 9.3% of patients at 30 days. Valve haemodynamics improved from baseline to 30 days (mean aortic valve gradient: from 47.6±14.5 mmHg to 8.6±3.9 mmHg; mean aortic valve area: from 0.7±0.2 cm2 to 1.6±0.4 cm2). At 30 days, PVL was evaluated as none/trace in 79.2% of patients, mild in 18.9%, moderate in 1.9%, and severe in 0%.CONCLUSIONS: The study results support the safety and efficacy of TAVI with ACURATE neo2 in patients in routine clinical practice.

Published
2023

46. Selection of patients for mechanical circulatory support for refractory out-of-hospital cardiac arrest

Author

Linde, Louise, Mørk, Sivagowry Rasalingam, Gregers, Emilie, Andreasen, Jo Bønding, Lassen, Jens Flensted, Ravn, Hanne Berg, Schmidt, Henrik, Riber, Lars Peter, Thomassen, Sisse Anette, Laugesen, Helle, Eiskjær, Hans, Terkelsen, Christian Juhl, Christensen, Steffen, Tang, Mariann, Moeller-Soerensen, Hasse, Holmvang, Lene, Kjaergaard, Jesper, Hassager, Christian, Moller, Jacob Eifer, Linde, Louise, Mørk, Sivagowry Rasalingam, Gregers, Emilie, Andreasen, Jo Bønding, Lassen, Jens Flensted, Ravn, Hanne Berg, Schmidt, Henrik, Riber, Lars Peter, Thomassen, Sisse Anette, Laugesen, Helle, Eiskjær, Hans, Terkelsen, Christian Juhl, Christensen, Steffen, Tang, Mariann, Moeller-Soerensen, Hasse, Holmvang, Lene, Kjaergaard, Jesper, Hassager, Christian, and Moller, Jacob Eifer

Abstract

Objective: To describe characteristics of patients admitted with refractory cardiac arrest for possible extracorporeal cardiopulmonary resuscitation (ECPR) and gain insight into the reasons for refraining from treatment in some. Methods: Nationwide retrospective cohort study involving all tertiary centres providing ECPR in Denmark. Consecutive patients admitted with ongoing chest compression for evaluation for ECPR treatment were enrolled. Presenting characteristics, duration of no-flow and low-flow time, end-tidal carbon dioxide (ETCO2), lactate and pH, and recording of reasons for refraining from ECPR documented by the treating team were recorded. Outcomes were survival to intensive care unit admission and survival to hospital discharge. Results: Of 579 patients admitted with refractory cardiac arrest for possible ECPR, 221 patients (38%) proceeded to ECPR and 358 patients (62%) were not considered candidates. Median prehospital low-flow time was 70 min (IQR 56 to 85) in ECPR patients and 62 min (48 to 81) in no-ECPR patients, p<0.001. Intra-arrest transport was more than 50 km in 92 (42%) ECPR patients and 135 in no-ECPR patients (38%), p=0.25. The leading causes for not initiating ECPR stated by the treating team were duration of low-flow time in 39%, severe metabolic derangement in 35%, and in 31% low ETCO2. The prevailing combination of contributing factors were non-shockable rhythm, low ETCO2, and metabolic derangement or prehospital low-flow time combined with low ETCO2. Survival to discharge was only achieved in six patients (1.7%) in the no-ECPR group. Conclusions: In this large nationwide study of patients admitted for possible ECPR, two-thirds of patients were not treated with ECPR. The most frequent reasons to abstain from ECPR were long duration of prehospital low-flow time, metabolic derangement and low ETCO2.

Published
2023

47. Long‐term outcomes after coronary intervention with biodegradable polymer stents in patients with acute coronary syndromes.

Author

Noori, Manijeh, Christiansen, Evald Høj, Raungaard, Bent, Junker, Anders, Christensen, Martin Kirk, Kahlert, Johnny, Maeng, Michael, Freeman, Phillip, Hansen, Kirstine Nørregaard, Terkelsen, Christian Juhl, Ellert‐Gregersen, Julia, Kristensen, Steen Dalby, Veien, Karsten Tange, Jakobsen, Lars, and Jensen, Lisette Okkels

Published
2024
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48. Real-World Experience with Cangrelor as Adjuvant to Percutaneous Coronary Intervention: A Single-Centre Observational Study

Author

Thim, Troels, primary, Jakobsen, Lars, additional, Jensen, Rebekka Vibjerg, additional, Støttrup, Nicolaj, additional, Eftekhari, Ashkan, additional, Grove, Erik Lerkevang, additional, Larsen, Sanne Bøjet, additional, Sørensen, Jacob Thorsted, additional, Carstensen, Steen, additional, Amiri, Sahar, additional, Veien, Karsten Tange, additional, Christiansen, Evald Høj, additional, Terkelsen, Christian Juhl, additional, Maeng, Michael, additional, and Kristensen, Steen Dalby, additional

Published
2023
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49. Clinical outcomes of the ACURATE neo2 transcatheter heart valve:&nbsp;a prospective, multicentre, observational, post-market surveillance study

Author

Kim, Won-Keun, primary, Tamburino, Corrado, additional, Möllmann, Helge, additional, Montorfano, Matteo, additional, Ellert-Gregersen, Julia, additional, Rudolph, Tanja K., additional, Van Mieghem, Nicolas M., additional, Hilker, Michael, additional, Amat-Santos, Ignacio J., additional, Terkelsen, Christian Juhl, additional, Petronio, Anna Sonia, additional, Stella, Pieter R., additional, Götberg, Matthias, additional, Rück, Andreas, additional, Kasel, A. Markus, additional, Trillo, Ramiro, additional, Appleby, Clare, additional, Barbanti, Marco, additional, Blanke, Philipp, additional, Modolo, Rodrigo, additional, Allocco, Dominic J., additional, and Sondergaard, Lars, additional

Published
2023
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