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1. Real-world routine diagnostic molecular analysis for TP53 mutational status is recommended over p53 immunohistochemistry in B-cell lymphomas

Author

de Haan, Lorraine M., de Groen, Ruben A. L., de Groot, Fleur A., Noordenbos, Troy, van Wezel, Tom, van Eijk, Ronald, Ruano, Dina, Diepstra, Arjan, Koens, Lianne, Nicolae-Cristea, Alina, Hartog, Wietske C. E. den, Terpstra, Valeska, Ahsmann, Els, Dekker, Tim J. A., Sijs-Szabo, Aniko, Veelken, Hendrik, Cleven, Arjen H. G., Jansen, Patty M., and Vermaat, Joost S. P.

Published
2024
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2. Clinical characteristics and survival outcomes of patients with primary central nervous system lymphoma treated with high-dose methotrexate-based polychemotherapy and consolidation therapies

Author

de Groot, Fleur A., Dekker, Tim J.A., Doorduijn, Jeanette K., Böhringer, Stefan, Brink, Mirian, de Groen, Ruben A.L., de Haan, Lorraine M., Woei-A-Jin, F.J. Sherida H., Noordenbos, Troy, Sijs-Szabo, Aniko, Oudshoorn, Mirjam A., Lam, King H., Diepstra, Arjan, te Boome, Liane C.J., Terpstra, Valeska, Bohmer, Lara H., Nicolae, Alina, Posthuma, Eduardus F.M., Koens, Lianne, Durian, Marc F., Stavast, Jeroen, van der Poel, Marjolein W.M., Hamid, Myrurgia Abdul, Stevens, Wendy B.C., van Rooij, Sjo L.M., Oostvogels, Rimke S., Mühlebner, Angelika, Neelis, Karen J., van den Brand, Michiel, Tousseyn, Thomas, Dierickx, Daan, de Weerdt, Okke, Beeker, Aart, Jansen, Patty M., Kersten, Marie José, Zijlstra, Josée M., Chamuleau, Martine E.D., Veelken, Hendrik, Bromberg, Jacoline C.E., Nijland, Marcel, and Vermaat, Joost S.P.

Published
2024
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3. Results from the UNITED study: a multicenter study validating the prognostic effect of the tumor–stroma ratio in colon cancer

Author

Petrushevska, Gordana, Bogdanovska, Magdalena, Zdravkoski, Panche, Antovic, Svetozar, Dzambaz, Darko, Karagjozov, Panche, de Cuba, Erienne M.V., Beverdam, Frédérique, Jansen, Jan, Vermaas, Maarten, Gašljević, Gorana, Kjær-Frifeldt, Sanne, Lindebjerg, Jan, Strous, Maud, Vogelaar, Jeroen F., Bulkmans, Nicole W.J., van Baarlen, Joop, Mekenkamp, Leonie, Hoekstra, Ronald, Sie, Mark, Cuatrecasas, Miriam, Simonetti, Sara, Rodrigo, María Teresa, Sanz, Iván Archilla, Guerrero Pineda, Jose, Leeuwis-Fedorovich, Natalja E., Talsma, Koen A., Souza da Silva, Ricella M., Lacle, Miangela M., Koopman, Miriam, Dekker, Jan Willem T., van Tilburg, Arjan, Nuciforo, Paolo, Villalobos Alberú, Xenia, Landolfi, Stefania, Zucchiatti, Adriana, Witteveen, Emma, Bordbar, Arad, Hendriks, Mathijs P., Arensman, René, Natu, Shonali, Maka, Noori, Mesker, Wilma E., Tollenaar, Rob A.E.M., Polack, Meaghan, Smit, Marloes A., van Pelt, Gabi W., Putter, Hein, Meershoek-Kleinenbarg, Elma, Roodvoets, Annet G.H., Crobach, Augustinus S.L.P., Gelderblom, Hans, Fontes e Sousa, Mário, Borralho Nunes, Paula, Cruz, João, Raimundo, Ana, Silva, Nelson, Brito, Maria J., Terpstra, Valeska, Zakhartseva, L.M., Al Dieri, Raed, Fléjou, Jean-François, Feakins, Roger, Dequeker, Els, Vink, Geraldine R., van Krieken, J.Han J.M., Polack, M., Smit, M.A., van Pelt, G.W., Roodvoets, A.G.H., Meershoek-Klein Kranenbarg, E., Putter, H., Gelderblom, H., Crobach, A.S.L.P., Terpstra, V., Petrushevska, G., Gašljević, G., Kjær-Frifeldt, S., de Cuba, E.M.V., Bulkmans, N.W.J., Vink, G.R., Al Dieri, R., Tollenaar, R.A.E.M., van Krieken, J.H.J.M., and Mesker, W.E.

Published
2024
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5. Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype

Author

de Groen, Ruben A.L., van Eijk, Ronald, Böhringer, Stefan, van Wezel, Tom, Raghoo, Richard, Ruano, Dina, Jansen, Patty M., Briaire-de Bruijn, Inge, de Groot, Fleur A., Kleiverda, Karin, te Boome, Liane, Terpstra, Valeska, Levenga, Henriette, Nicolae, Alina, Posthuma, Eduardus F.M., Focke-Snieders, Isabelle, Hardi, Lizan, den Hartog, Wietske C.E., Bohmer, Lara H., Hogendoorn, Pancras C.W., van den Berg, Anke, Diepstra, Arjan, Nijland, Marcel, Lugtenburg, Pieternella J., Kersten, Marie José, Pals, Steven T., Veelken, Hendrik, Bovée, Judith V.M.G., Cleven, Arjen H.G., and Vermaat, Joost S.P.

Published
2021
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6. Results from the UNITED study: a multicenter study validating the prognostic effect of the tumor–stroma ratio in colon cancer

Author

Polack, M., primary, Smit, M.A., additional, van Pelt, G.W., additional, Roodvoets, A.G.H., additional, Meershoek-Klein Kranenbarg, E., additional, Putter, H., additional, Gelderblom, H., additional, Crobach, A.S.L.P., additional, Terpstra, V., additional, Petrushevska, G., additional, Gašljević, G., additional, Kjær-Frifeldt, S., additional, de Cuba, E.M.V., additional, Bulkmans, N.W.J., additional, Vink, G.R., additional, Al Dieri, R., additional, Tollenaar, R.A.E.M., additional, van Krieken, J.H.J.M., additional, Mesker, W.E., additional, Petrushevska, Gordana, additional, Bogdanovska, Magdalena, additional, Zdravkoski, Panche, additional, Antovic, Svetozar, additional, Dzambaz, Darko, additional, Karagjozov, Panche, additional, de Cuba, Erienne M.V., additional, Beverdam, Frédérique, additional, Jansen, Jan, additional, Vermaas, Maarten, additional, Gašljević, Gorana, additional, Kjær-Frifeldt, Sanne, additional, Lindebjerg, Jan, additional, Strous, Maud, additional, Vogelaar, Jeroen F., additional, Bulkmans, Nicole W.J., additional, van Baarlen, Joop, additional, Mekenkamp, Leonie, additional, Hoekstra, Ronald, additional, Sie, Mark, additional, Cuatrecasas, Miriam, additional, Simonetti, Sara, additional, Rodrigo, María Teresa, additional, Sanz, Iván Archilla, additional, Guerrero Pineda, Jose, additional, Leeuwis-Fedorovich, Natalja E., additional, Talsma, Koen A., additional, Souza da Silva, Ricella M., additional, Lacle, Miangela M., additional, Koopman, Miriam, additional, Dekker, Jan Willem T., additional, van Tilburg, Arjan, additional, Nuciforo, Paolo, additional, Villalobos Alberú, Xenia, additional, Landolfi, Stefania, additional, Zucchiatti, Adriana, additional, Witteveen, Emma, additional, Bordbar, Arad, additional, Hendriks, Mathijs P., additional, Arensman, René, additional, Natu, Shonali, additional, Maka, Noori, additional, Mesker, Wilma E., additional, Tollenaar, Rob A.E.M., additional, Polack, Meaghan, additional, Smit, Marloes A., additional, van Pelt, Gabi W., additional, Putter, Hein, additional, Meershoek-Kleinenbarg, Elma, additional, Roodvoets, Annet G.H., additional, Crobach, Augustinus S.L.P., additional, Gelderblom, Hans, additional, Fontes e Sousa, Mário, additional, Borralho Nunes, Paula, additional, Cruz, João, additional, Raimundo, Ana, additional, Silva, Nelson, additional, Brito, Maria J., additional, Terpstra, Valeska, additional, Zakhartseva, L.M., additional, Al Dieri, Raed, additional, Fléjou, Jean-François, additional, Feakins, Roger, additional, Dequeker, Els, additional, Vink, Geraldine R., additional, and van Krieken, J.Han J.M., additional

Published
2024
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7. Real-world routine diagnostic molecular analysis for TP53 mutational status is recommended over p53 immunohistochemistry in B-cell lymphomas

Author

de Haan, Lorraine M., primary, de Groen, Ruben A. L., additional, de Groot, Fleur A., additional, Noordenbos, Troy, additional, van Wezel, Tom, additional, van Eijk, Ronald, additional, Ruano, Dina, additional, Diepstra, Arjan, additional, Koens, Lianne, additional, Nicolae-Cristea, Alina, additional, Hartog, Wietske C. E. den, additional, Terpstra, Valeska, additional, Ahsmann, Els, additional, Dekker, Tim J. A., additional, Sijs-Szabo, Aniko, additional, Veelken, Hendrik, additional, Cleven, Arjen H. G., additional, Jansen, Patty M., additional, and Vermaat, Joost S. P., additional

Published
2023
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11. Targeted next-generation sequencing has incremental value in the diagnostic work-up of patients with suspect pancreatic masses; a multi-center prospective cross sectional study

Author

Achterberg, Friso B, Mulder, Babs G Sibinga, Janssen, Quisette P, Koerkamp, Bas Groot, Hol, Lieke, Quispel, Rutger, Bonsing, Bert A, Vahrmeijer, Alexander L, van Eijck, Casper H J, Roos, Daphne, Perk, Lars E, van der Harst, Erwin, Coene, Peter-Paul L O, Doukas, Michail, Smedts, Frank M M, Kliffen, Mike, van Velthuysen, Marie-Louise F, Terpstra, Valeska, Sarasqueta, Arantza Farina, Morreau, Hans, Mieog, J Sven D, Achterberg, Friso B, Mulder, Babs G Sibinga, Janssen, Quisette P, Koerkamp, Bas Groot, Hol, Lieke, Quispel, Rutger, Bonsing, Bert A, Vahrmeijer, Alexander L, van Eijck, Casper H J, Roos, Daphne, Perk, Lars E, van der Harst, Erwin, Coene, Peter-Paul L O, Doukas, Michail, Smedts, Frank M M, Kliffen, Mike, van Velthuysen, Marie-Louise F, Terpstra, Valeska, Sarasqueta, Arantza Farina, Morreau, Hans, and Mieog, J Sven D

Abstract

BACKGROUND: The diagnostic process of patients with suspect pancreatic lesions is often lengthy and prone to repeated diagnostic procedures due to inconclusive results. Targeted Next-Generation Sequencing (NGS) performed on cytological material obtained with fine needle aspiration (FNA) or biliary duct brushing can speed up this process. Here, we study the incremental value of NGS for establishing the correct diagnosis, and subsequent treatment plan in patients with inconclusive diagnosis after regular diagnostic work-up for suspect pancreatic lesions.METHODS: In this prospective cross-sectional cohort study, patients were screened for inclusion in four hospitals. NGS was performed with AmpliSeq Cancer Hotspot Panel v2 and v4b in patients with inconclusive cytology results or with an uncertain diagnosis. Diagnostic results were evaluated by the oncology pancreatic multidisciplinary team. The added value of NGS was determined by comparing diagnosis (malignancy, cystic lesion or benign condition) and proposed treatment plan (exploration/resection, neoadjuvant chemotherapy, follow-up, palliation or repeated FNA) before and after integration of NGS results. Final histopathological analysis or a 6-month follow-up period were used as the reference standard in case of surgical intervention or non-invasive treatment, respectively.RESULTS: In 50 of the 53 included patients, cytology material was sufficient for NGS analysis. Diagnosis before and after integration of NGS results differed in 24% of the patients. The treatment plan was changed in 32% and the diagnosis was substantiated by the NGS data in 44%. Repetition of FNA/brushing was prevented in 14% of patients. All changes in treatment plan were correctly made after integration of NGS. Integration of NGS increased overall diagnostic accuracy from 68% to 94%.INTERPRETATION: This study demonstrates the incremental diagnostic value of NGS in patients with an initial inconclusive diagnosis. Integratio

Published
2023

12. Uniform Noting for International application of the Tumor-stroma ratio as Easy Diagnostic tool: The UNITED study - An update

Author

Polack, Meaghan, primary, Smit, Marloes A., additional, Crobach, Stijn A.L.P., additional, Terpstra, Valeska, additional, Roodvoets, Annet G.H., additional, Meershoek-Klein Kranenbarg, Elma M., additional, Dequeker, Els M.C., additional, van der Laak, Jeroen A., additional, Tollenaar, Rob A.E.M., additional, van Krieken, Han J.H.J.M., additional, and Mesker, Wilma E., additional

Published
2023
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13. Oncological Safety and Potential Cost Savings of Routine vs Selective Histopathological Examination After Appendectomy Results of the Multicenter, Prospective, Cross-Sectional FANCY Study

Author

Bastiaenen, Vivian P., de Jonge, Joske, Corten, Bartholomeus J. G. A., de Savornin Lohman, Elise A. J., Kraima, Anne C., Swank, Hilko A., van Vliet, Jaap L. P., van Acker, Gijs J. D., van Geloven, Anna A. W., in'tHof, Klaas H., Koens, Lianne, de Reuver, Philip R., van Rossem, Charles C., Slooter, Gerrit D., Tanis, Pieter J., Terpstra, Valeska, Dijkgraaf, Marcel G. W., Bemelman, Willem A., Amelung, F. J., Atema, J. J., Bessems, S., Beunders, A. A. M., Bodewes, T. C. F., den Boer, F. C., Boerma, D., Boerma, E. G., van den Boezem, P., Bökkerink, W. J. V., van den Boogaart, D., Boogerd, L. S. F., Bouwman, H., Broos, A., Brueren, L. O., Bruinsma, W. E., Bruns, E. R. C., Castelijns, P. S. S., de Castro, S. M. M., Consten, E. C. J., Crolla, R. M. P. H., Dam, M. J., Dang, Q., Dekker, J. W. T., Deroose, J. P., Devriendt, S., Dijkema, E. J., Dijkstra, N., Driessen, M. L. S., van Duijvendijk, P., Duinhouwer, L. E., van Duyn, E. B., el-Massoudi, Y., Elfrink, A. K. E., Elschot, J. H., van Essen, J. A., Ferenschild, F. T. J., Gans, S. L., Gaznay, C., Geraedts, A. C. M., van Gessel, B. S. H., Giesen, L. J. X., van Gils, N., Gorgec, B., Gorter, R. R., Govaert, K. M., Greuter, G. N., van Grevenstein, W. M. U., Groot, L., Hardy, J. C. A., Heemskerk, J., Heeren, J. F., Heidotting, J., Heikens, J. T., Hosseinzoi, E., van Iersel, J. J., Inberg, B., Jansen, L. J., Jens, A. J. T., Jilesen, A. P. J., Joosten, M., de Jong, L., Keijzers, M., Klicks, R. J., Kloppenberg, F. W. H., Koedam, T. W. A., Koëter, T., Konsten, J. L. M., Koolen, L. J. E. R., Kruyt, Ph. M., Lange, J. F. M., Lavrijssen, B. D. A., de Leede, E. M., Leliefeld, P. H. C., Linnemann, R. J. A., Lo, G. C., van de Loo, M., Lubbert, P. H. W., Holzik, M. F. Lutke, Manusama, E., Masselink, I., Matthée, E. P. C., Matthijsen, R. A., Mearadji, A., Melenhorst, J., Merkus, J. W. S., Michiels, T. D., Moes, D. E., Moossdorff, M., Mulder, E., Nallayici, E. G., Neijenhuis, P. A., Nielsen, K., Nieuwenhuijzen, G. A. P., Nijhuis, J., Okkema, S., Olthof, P. B., van Onkelen, R. S., van Oostendorp, S. E., Plaisier, P. W., Polle, S. W., Reiber, B. M. M., Reichert, F. C. M., van Rest, K. L. C., van Rijn, R., Roozendaal, N. C., de Ruijter, W. M. J., Schat, E., Scheerhoorn, J., Scheijmans, J. C. G., Schimmer, J., Schipper, R. J., Schouten, R., Schreurs, W. H., Schrijver, W. A. M. E., Shapiro, J., Siemons, A., Silvis, R., Simkens, G. A., Smakman, N., Smeets, B. J. J., Sonneveld, D. J. A., van Suijlichem, M., Talsma, A. K., Thoolen, J. M. M., van Tol, R. R., Tournoij, E., Tseng, L. N. L., Tuynman, J. B., van der Velde, K., Veltkamp, S. C., Verbeek, F. P. R., Verdaasdonk, E., Verhaak, T., Verheuvel, N. C., Vermaas, M., Verseveld, M., Vlek, S., Vogels, S., van de Voort, E. M. F., van Vugt, S. T., Wegdam, J. A., Wennekers, M. M., Wiering, B., de Wijkerslooth, E. M. L., Wijkmans, A. A., Wijnhoven, B. P. L., Witjes, C. D. M., Wolfhagen, N., de Zeeuw, S., van Zoonen, G., Surgery, Erasmus MC other, Obstetrics & Gynecology, Department of Strategic Management and Entrepreneurship, Neurology, Rotterdam School of Management, Cardiology, Gastroenterology & Hepatology, Radiology & Nuclear Medicine, Otorhinolaryngology and Head and Neck Surgery, Emergency Medicine, Public Health, Plastic and Reconstructive Surgery and Hand Surgery, Dermatology, Clinical Chemistry, Internal Medicine, Erasmus School of Social and Behavioural Sciences, General Practice, Radiotherapy, Research & Education, Rehabilitation Medicine, Urology, Pathology, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Hematology laboratory, VU University medical center, CCA - Cancer Treatment and quality of life, and CCA - Imaging and biomarkers

Subjects
medicine.medical_specialty, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], All institutes and research themes of the Radboud University Medical Center, business.industry, General surgery, Medicine, Surgery, Histopathological examination, business, Cost savings
Abstract

Objective: To investigate the oncological safety and potential cost savings of selective histopathological examination after appendectomy. Background: The necessity of routine histopathological examination after appendectomy has been questioned, but prospective studies investigating the safety of a selective policy are lacking. Methods: In this multicenter, prospective, cross-sectional study, inspection and palpation of the (meso)appendix was performed by the surgeon in patients with suspected appendicitis. The surgeon's opinion on additional value of histopathological examination was reported before sending all specimens to the pathologist. Main outcomes were the number of hypothetically missed appendiceal neoplasms with clinical consequences benefiting the patient (upper limit two-sided 95% confidence interval below 3:1000 considered oncologically safe) and potential cost savings after selective histopathological examination. Results: Seven thousand three hundred thirty-nine patients were included. After a selective policy, 4966/7339 (67.7%) specimens would have been refrained from histopathological examination. Appendiceal neoplasms with clinical consequences would have been missed in 22/4966 patients. In 5/22, residual disease was completely resected during additional surgery. Hence, an appendiceal neoplasm with clinical consequences benefiting the patient would have been missed in 1.01:1000 patients (upper limit 95% confidence interval 1.61:1000). In contrast, twice as many patients (10/22) would not have been exposed to potential harm due to re-resections without clear benefit, whereas consequences were neither beneficial nor harmful in the remaining seven. Estimated cost savings established by replacing routine for selective histopathological examination were 725,400 per 10,000 patients. Conclusions: Selective histopathological examination after appendectomy for suspected appendicitis is oncologically safe and will likely result in a reduction of pathologists' workload, less costs, and fewer re-resections without clear benefit.

Published
2023
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14. Targeted next-generation sequencing has incremental value in the diagnostic work-up of patients with suspect pancreatic masses; a multi-center prospective cross sectional study

Author

Achterberg, Friso B., primary, Mulder, Babs G. Sibinga, additional, Janssen, Quisette P., additional, Koerkamp, Bas Groot, additional, Hol, Lieke, additional, Quispel, Rutger, additional, Bonsing, Bert A., additional, Vahrmeijer, Alexander L., additional, van Eijck, Casper H. J., additional, Roos, Daphne, additional, Perk, Lars E., additional, van der Harst, Erwin, additional, Coene, Peter-Paul L. O., additional, Doukas, Michail, additional, Smedts, Frank M. M., additional, Kliffen, Mike, additional, van Velthuysen, Marie-Louise F., additional, Terpstra, Valeska, additional, Sarasqueta, Arantza Farina, additional, Morreau, Hans, additional, and Mieog, J. Sven D., additional

Published
2023
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15. Polyostotic DLBCL Is Characterized By a NF-Κb Pathway Affecting Molecular Profile and Superior Survival

Author

De Groen, Ruben A.L., primary, De Groot, Fleur A, additional, De Haan, Lorraine M., additional, van Wezel, Tom, additional, Noordenbos, Troy, additional, Boehringer, Stefan, additional, Van Eijk, Ronald, additional, Raghoo, Richard, additional, Ruano, Dina, additional, Sijs-Szabo, Aniko, additional, te Boome, Liane, additional, Terpstra, Valeska, additional, Levenga, Henriette, additional, Nicolae, Aline, additional, Posthuma, Ward, additional, Focke-Snieders, Isabelle, additional, Hardi, Lizan, additional, den Hartog, Wietske, additional, Böhmer, Lara H., additional, Van Den Berg, Anke, additional, Mutseaers, Pim, additional, Van Der Poel, Marjolein W.M., additional, Abdul Hamid, Myrurgia, additional, Woei-a-Jin, F.J. Sherida H., additional, Janssens, Ann, additional, Tousseyn, Thomas, additional, Bovée, Judith, additional, Veelken, Hendrik, additional, Pals, Steven T, additional, Diepstra, Arjan, additional, Nijland, Marcel, additional, Kersten, Marie José, additional, Jansen, Patty M., additional, Cleven, Arjen, additional, and Vermaat, Joost S.P., additional

Published
2022
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16. Consolidation Improves Survival in Primary Central Nervous System Lymphoma without Preference for Type of High-Dose Methotrexate-Based Induction Treatment Regimen

Author

De Groot, Fleur A, primary, Doorduijn, Jeanette K., additional, Brink, Mirian, additional, De Groen, Ruben A.L., additional, De Haan, Lorraine M., additional, Noordenbos, Troy, additional, Sijs-Szabo, Aniko, additional, Lam, King Hong, additional, Diepstra, Arjan, additional, te Boome, Liane, additional, Terpstra, Valeska, additional, Böhmer, Lara H., additional, Zijlstra, Josée M., additional, Koens, Lianne, additional, Durian, Marc, additional, Oudshoorn, Mirjam A., additional, Veelken, Hendrik, additional, Van Der Poel, Marjolein W.M., additional, Abdul Hamid, Myrurgia, additional, Stevens, Wendy B.C., additional, van Rooij, J L.M, additional, Oostvogels, Rimke, additional, Neelis, Karen J., additional, van den Brand, Michiel, additional, Woei-a-Jin, F.J. Sherida H., additional, Tousseyn, Thomas, additional, Dierickx, Daan, additional, Jansen, Patty M., additional, Kersten, Marie Jose, additional, Bromberg, Jacoline, additional, Nijland, Marcel, additional, and Vermaat, Joost S.P., additional

Published
2022
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17. Special Anatomical Subtypes of Diffuse Large B-Cell Lymphoma Have Distinct Tumor Microenvironments

Author

Noordenbos, Troy, primary, De Groot, Fleur A, additional, De Groen, Ruben A.L., additional, De Haan, Lorraine M., additional, Krog, Ricki T., additional, Sijs-Szabo, Aniko, additional, Griffioen, Marieke, additional, de Groot, Rosa, additional, Heemskerk, Mirjam H.M., additional, Ijsselsteijn, Marieke E., additional, Terpstra, Valeska, additional, Nijland, Marcel, additional, Mutseaers, Pim, additional, Chamuleau, Martine E.D., additional, Kersten, Marie Jose, additional, Diepstra, Arjan, additional, Bovée, Judith, additional, Jansen, Patty M., additional, De Miranda, Noel F.C.C., additional, and Vermaat, Joost S.P., additional

Published
2022
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22. Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype

Author

de Groen, A. L., van Eijk, Ronald, Bohringer, Stefan, Wezel, Tom van, Raghoo, Richard, Ruano, Dina, Jansen, Patty M., Briaire-De Bruijn, Inge, de Groot, Fleur A., Kleiverda, Karin, te Boome, Liane, Terpstra, Valeska, Levenga, Henriette, Nicolae, Alina, Posthuma, Eduardus F.M., Focke-Snieders, Isabelle, Hardi, Lizan, den Hartog, Wietske C.E., Bohmer, Lara H., Hogendoorn, Pancras C.W., den Berg, Anke van, Diepstra, Arjan, Nijland, Marcel, Lugtenburg, Pieternella J., Kersten, Marie Jose, Pals, Steven T., Veelken, Hendrik, Bovee, Judith V.M.G., Cleven, Arjen H.G., Vermaat, Joost S.P., de Groen, A. L., van Eijk, Ronald, Bohringer, Stefan, Wezel, Tom van, Raghoo, Richard, Ruano, Dina, Jansen, Patty M., Briaire-De Bruijn, Inge, de Groot, Fleur A., Kleiverda, Karin, te Boome, Liane, Terpstra, Valeska, Levenga, Henriette, Nicolae, Alina, Posthuma, Eduardus F.M., Focke-Snieders, Isabelle, Hardi, Lizan, den Hartog, Wietske C.E., Bohmer, Lara H., Hogendoorn, Pancras C.W., den Berg, Anke van, Diepstra, Arjan, Nijland, Marcel, Lugtenburg, Pieternella J., Kersten, Marie Jose, Pals, Steven T., Veelken, Hendrik, Bovee, Judith V.M.G., Cleven, Arjen H.G., and Vermaat, Joost S.P.

Published
2021

27. Safety and economic analysis of selective histopathology following cholecystectomy: multicentre, prospective, cross-sectional FANCY study.

Author

Bastiaenen, Vivian P., van Vliet, Jaap L. P., de Savornin Lohman, Elise A. J., Corten, Bartholomeus J. G. A., de Jonge, Joske, Kraima, Anne C., Swank, Hilko A., van Acker, Gijs J. D., van Geloven, Anna A. W., in 't Hof, Klaas H., Koens, Lianne, de Reuver, Philip R., van Rossem, Charles C., Slooter, Gerrit D., Tanis, Pieter J., Terpstra, Valeska, Dijkgraaf, Marcel G. W., and Bemelman, Willem A.

Subjects
CHOLECYSTITIS, GALLBLADDER cancer, HISTOPATHOLOGY, GALLSTONES, CROSS-sectional method, PATHOLOGISTS, CHOLECYSTECTOMY, PATHOLOGY
Abstract

Background: There is ongoing debate concerning the necessity of routine histopathological examination following cholecystectomy. In order to reduce the pathology workload and save costs, a selective approach has been suggested, but evidence regarding its oncological safety is lacking. Methods: In this multicentre, prospective, cross-sectional study, all gallbladders removed for gallstone disease or cholecystitis were systematically examined by the surgeon for macroscopic abnormalities indicative of malignancy. Before sending all specimens to the pathologist, the surgeon judged whether histopathological examination was indicated. The main outcomes were the number of patients with hypothetically missed malignancy with clinical consequences (upper limit two-sided 95 per cent c.i. below 3:1000 considered oncologically safe) and potential cost savings of selective histopathological examination. Results: Twenty-two (2.19:1000) of 10 041 specimens exhibited malignancy with clinical consequences. In case of a selective policy, surgeons would have held back 7846 of 10041 (78.1 per cent) gallbladders from histopathological examination. Malignancy with clinical consequences would have been missed in seven of 7846 patients (0.89:1000, upper limit 95% c.i. 1.40:1000). No patient benefitted from the clinical consequences, while two were harmed (futile additional surgery). Of 15 patients in whom malignancy with clinical consequences would have been diagnosed, one benefitted (residual disease radically removed), two potentially benefitted (palliative systemic therapy), and four experienced harm (futile additional surgery). Estimated cost savings established by replacing routine for selective histopathological examination were €703 500 per 10 000 patients. Conclusion: Selective histopathological examination following cholecystectomy is oncologically safe and could reduce pathology workload, costs, and futile re-resections. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Scavenger Receptors, Oxidized LDL, and Atherosclerosis

Author

BOULLIER, AGNES, BIRD, DAVID A., CHANG, MI-KYUNG, DENNIS, EDWARD A., FRIEDMAN, PETER, GILLOTTE-TAYLOR, KRISTIN, HÖRKKÖ, SOHVI, PALINSKI, WULF, QUEHENBERGER, OSWALD, SHAW, PETER, STEINBERG, DANIEL, TERPSTRA, VALESKA, and WITZTUM, JOSEPH L.

Published
2001

29. Safety and cost analysis of selective histopathological examination following appendicectomy and cholecystectomy (FANCY study): protocol and statistical analysis plan of a prospective observational multicentre study

Author

Bastiaenen, Vivian P, primary, Corten, Bartholomeus JGA, additional, de Savornin Lohman, Elise AJ, additional, de Jonge, Joske, additional, Kraima, Anne C, additional, Swank, Hilko A, additional, van Vliet, Jaap LP, additional, van Acker, Gijs JD, additional, van Geloven, Anna AW, additional, in 't Hof, Klaas H, additional, Koens, Lianne, additional, de Reuver, Philip R, additional, van Rossem, Charles C, additional, Slooter, Gerrit D, additional, Tanis, Pieter J, additional, Terpstra, Valeska, additional, Dijkgraaf, Marcel GW, additional, and Bemelman, Willem A, additional

Published
2019
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30. High Frequencies of Mutated EZH2 and IRF8 and Other Epigenetic Genes in Primary Bone Lymphomas Are Indicative of GCB-Phenotype

Author

De Groen, Ruben A.L., primary, Van Eijk, Ronald, additional, van Wezel, Tom, additional, Raghoo, Richard, additional, Schrader, Anne-Roos, additional, Jansen, Patty M., additional, briaire-De Bruijn, Inge, additional, Kleiverda, Karin, additional, Vlasveld, Tom, additional, Terpstra, Valeska, additional, Levenga, Henriette, additional, Nicolae, Aline, additional, Posthuma, Ward, additional, Focke-Snieders, Isabelle, additional, Hardi, Lizan, additional, den Hartog, Wietske, additional, Van Den Berg, Anke, additional, Diepstra, Arjan, additional, Lugtenburg, Pieternella, additional, Kersten, Marie José, additional, Pals, Steven T, additional, Veelken, Hendrik, additional, Bovée, Judith, additional, Cleven, Arjen, additional, and Vermaat, Joost, additional

Published
2019
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31. Acute Clinical Manifestation of Mesenteric Heterotopic Pancreatitis: A Pre- and Postoperative Confirmed Case

Author

de Kok, Bente M., de Korte, Fleur I., Perk, Lars E., Terpstra, Valeska, Mieog, J. Sven D., and Zijta, Frank M.

Subjects
Article Subject
Abstract

Heterotopic pancreas is a relatively uncommon congenital anomaly, defined as pancreatic tissue in ectopic sites without an anatomic and vascular continuity with the main body of the pancreas. We report the case of a 58-year-old woman who was admitted to the hospital with the clinical suspicion of a mild, acute pancreatitis. Computed tomography, magnetic resonance imaging, transabdominal ultrasound, and endoscopic ultrasound revealed a normal orthotopic pancreas and the suspicion of a large heterotopic pancreas in the small bowel mesentery with signs of acute inflammation. The diagnosis of mesenteric heterotopic pancreatitis was preoperatively confirmed by endoscopic ultrasound-guided fine-needle aspiration and consequently histologically established after surgical resection.

Published
2018
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32. Frequent mutated B2M, EZH2, IRF8, and TNFRSF14in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype

Author

de Groen, Ruben A.L., van Eijk, Ronald, Böhringer, Stefan, van Wezel, Tom, Raghoo, Richard, Ruano, Dina, Jansen, Patty M., Briaire-de Bruijn, Inge, de Groot, Fleur A., Kleiverda, Karin, te Boome, Liane, Terpstra, Valeska, Levenga, Henriette, Nicolae, Alina, Posthuma, Eduardus F.M., Focke-Snieders, Isabelle, Hardi, Lizan, den Hartog, Wietske C.E., Bohmer, Lara H., Hogendoorn, Pancras C.W., van den Berg, Anke, Diepstra, Arjan, Nijland, Marcel, Lugtenburg, Pieternella J., Kersten, Marie José, Pals, Steven T., Veelken, Hendrik, Bovée, Judith V.M.G., Cleven, Arjen H.G., and Vermaat, Joost S.P.

Abstract

Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is a rare extranodal lymphoma subtype. This retrospective study elucidates the currently unknown genetic background of a large clinically well-annotated cohort of DLBCL with osseous localizations (O-DLBCL), including PB-DLBCL. A total of 103 patients with O-DLBCL were included and compared with 63 (extra)nodal non-osseous (NO)-DLBCLs with germinal center B-cell phenotype (NO-DLBCL-GCB). Cell-of-origin was determined by immunohistochemistry and gene-expression profiling (GEP) using (extended)-NanoString/Lymph2Cx analysis. Mutational profiles were identified with targeted next-generation deep sequencing, including 52 B-cell lymphoma-relevant genes. O-DLBCLs, including 34 PB-DLBCLs, were predominantly classified as GCB phenotype based on immunohistochemistry (74%) and NanoString analysis (88%). Unsupervised hierarchical clustering of an extended-NanoString/Lymph2Cx revealed significantly different GEP clusters for PB-DLBCL as opposed to NO-DLBCL-GCB (P< .001). Expression levels of 23 genes of 2 different targeted GEP panels indicated a centrocyte-like phenotype for PB-DLBCL, whereas NO-DLBCL-GCB exhibited a centroblast-like constitution. PB-DLBCL had significantly more frequent mutations in four GCB-associated genes (ie, B2M, EZH2, IRF8, TNFRSF14) compared with NO-DLBCL-GCB (P= .031, P= .010, P= .047, and P= .003, respectively). PB-DLBCL, with its corresponding specific mutational profile, was significantly associated with a superior survival compared with equivalent Ann Arbor limited-stage I/II NO-DLBCL-GCB (P= .016). This study is the first to show that PB-DLBCL is characterized by a GCB phenotype, with a centrocyte-like GEP pattern and a GCB-associated mutational profile (both involved in immune surveillance) and a favorable prognosis. These novel biology-associated features provide evidence that PB-DLBCL represents a distinct extranodal DLBCL entity, and its specific mutational landscape offers potential for targeted therapies (eg, EZH2 inhibitors).

Published
2021
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34. Noncirrhotic Portal Hypertension in Perinatally HIV-infected Adolescents Treated With Didanosine-containing Antiretroviral Regimens in Childhood

Author

Scherpbier, Henriette J., primary, Terpstra, Valeska, additional, Pajkrt, Dasja, additional, Puthakanit, Thanyawee, additional, Ananworanich, Jintanat, additional, Foster, Caroline, additional, van den Bergh Weerman, Marius, additional, Deurloo, Eline E., additional, van der Valk, Marc, additional, Kuijpers, Taco W., additional, and Koot, Bart G., additional

Published
2016
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35. An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B

Author

Jansen, Louis, primary, de Niet, Annikki, additional, Makowska, Zuzanna, additional, Dill, Michael T., additional, van Dort, Karel A., additional, Terpstra, Valeska, additional, Bart Takkenberg, R., additional, Janssen, Harry L.A., additional, Heim, Markus H., additional, Kootstra, Neeltje A., additional, and Reesink, Hendrik W., additional

Published
2015
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36. Comparison of interobserver agreement of magnetic resonance elastography with histopathological staging of liver fibrosis

Author

Runge, Jurgen H., primary, Bohte, Anneloes E., additional, Verheij, Joanne, additional, Terpstra, Valeska, additional, Nederveen, Aart J., additional, van Nieuwkerk, Karin M. J., additional, de Knegt, Rob J., additional, Baak, Bert C., additional, Jansen, Peter L. M., additional, Sinkus, Ralph, additional, and Stoker, Jaap, additional

Published
2013
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37. Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C

Author

Bohte, Anneloes E., primary, de Niet, Annikki, additional, Jansen, Louis, additional, Bipat, Shandra, additional, Nederveen, Aart J., additional, Verheij, Joanne, additional, Terpstra, Valeska, additional, Sinkus, Ralph, additional, van Nieuwkerk, Karin M. J., additional, de Knegt, Rob J., additional, Baak, Bert C., additional, Jansen, Peter L. M., additional, Reesink, Henk W., additional, and Stoker, Jaap, additional

Published
2013
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38. Baseline Hepatitis B Surface Antigen (Hbsag) as Predictor of Sustained Hbsag Loss in Chronic Hepatitis B Patients Treated with Pegylated Interferon-α2A and Adefovir

Author

Takkenberg, R Bart, primary, Jansen, Louis, additional, De Niet, Annikki, additional, Zaaijer, Hans L, additional, Weegink, Christine J, additional, Terpstra, Valeska, additional, Dijkgraaf, Marcel GW, additional, Molenkamp, Richard, additional, Jansen, Peter LM, additional, Koot, Maarten, additional, Rijckborst, Vincent, additional, Janssen, Harry LA, additional, Beld, Marcel GHM, additional, and Reesink, Hendrik W, additional

Published
2013
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41. Detection of hepatitis B virus covalently closed circular DNA in paraffin-embedded and cryo-preserved liver biopsies of chronic hepatitis B patients

Author

Takkenberg, R. Bart, primary, Zaaijer, Hans L., additional, Menting, Sandra, additional, Weegink, Christine J., additional, Terpstra, Valeska, additional, Cornelissen, Marion, additional, Dijkgraaf, Marcel G.W., additional, Jansen, Peter L.M., additional, Reesink, Hendrik W., additional, and Beld, Marcel G.H.M., additional

Published
2010
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42. Scavenger Receptors, Oxidized LDL, and Atherosclerosis

Author

BOULLIER, AGNES, primary, BIRD, DAVID A., additional, CHANG, MI-KYUNG, additional, DENNIS, EDWARD A., additional, FRIEDMAN, PETER, additional, GILLOTTE-TAYLOR, KRISTIN, additional, HÖRKKÖ, SOHVI, additional, PALINSKI, WULF, additional, QUEHENBERGER, OSWALD, additional, SHAW, PETER, additional, STEINBERG, DANIEL, additional, TERPSTRA, VALESKA, additional, and WITZTUM, JOSEPH L., additional

Published
2006
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46. Baseline Hepatitis B Surface Antigen (Hbsag) as Predictor of Sustained Hbsag Loss in Chronic Hepatitis B Patients Treated with Pegylated Interferon-a2A and Adefovir

Author

Takkenberg, R Bart, Jansen, Louis, De Niet, Annikki, Zaaijer, Hans L, Weegink, Christine J, Terpstra, Valeska, Dijkgraaf, Marcel GW, Molenkamp, Richard, Jansen, Peter LM, Koot, Maarten, Rijckborst, Vincent, Janssen, Harry LA, Beld, Marcel GHM, and Reesink, Hendrik W

Abstract

Background In this study, we aimed to identify baseline predictors of response in chronic hepatitis B patients treated with a combination of pegylated interferon (PEG-IFN)-a2a and adefovir.Methods We treated 92 chronic hepatitis B patients (44 hepatitis B e antigen [HBeAg]-positive and 48 HBeAg-negative) with HBV DNA>100,000 copies/ml (>17,182 IU/ ml) with PEG-IFN and adefovir for 48 weeks and followed them up for 2 years. Baseline markers for HBeAg loss, combined response (HBeAg negativity, HBV DNA levels =2,000 IU/ml and alanine aminotransferase [ALT] normalization) and hepatitis B surface antigen (HBsAg) loss were evaluated.Results Two years after the end of treatment, rates of HBeAg loss and HBsAg loss in HBeAg-positive patients were 18/44 (41%) and 5/44 (11%), respectively. In HBeAg-negative patients, rates of combined response and HBsAg loss were 12/48 (25%) and 8/48 (17%), respectively. HBeAg-negative patients with HBsAg loss had lower baseline HBsAg levels than those without HBsAg loss (mean HBsAg 2.35 versus 3.55 log10IU/ml; P<0.001). They also had lower HBV DNA levels and were more often (PEG-)IFN experienced. Baseline HBsAg was the only independent predictor of HBsAg loss (OR 0.02; P=0.01).Conclusions With combination therapy of PEG-IFN and adefovir for 48 weeks, a high rate of HBsAg loss was observed in both HBeAg-positive (11%) and HBeAg-negative (17%) patients 2 years after treatment ended. In HBeAg-negative patients, a low baseline HBsAg level was a strong predictor for HBsAg loss.

Published
2013
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47. Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage...

Author

Ramparasad, Mysore P. and Terpstra, Valeska

Subjects
*CELL membranes, *MACROPHAGES, *LIPOPROTEINS
Abstract

Studies the cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein. Antibodies and flow cytommetry; Ligand and western blot analysis; Cell surface biotinylation.

Published
1996

48. High Frequencies of Mutated EZH2and IRF8and Other Epigenetic Genes in Primary Bone Lymphomas Are Indicative of GCB-Phenotype

Author

De Groen, Ruben A.L., Van Eijk, Ronald, van Wezel, Tom, Raghoo, Richard, Schrader, Anne-Roos, Jansen, Patty M., briaire-De Bruijn, Inge, Kleiverda, Karin, Vlasveld, Tom, Terpstra, Valeska, Levenga, Henriette, Nicolae, Aline, Posthuma, Ward, Focke-Snieders, Isabelle, Hardi, Lizan, den Hartog, Wietske, Van Den Berg, Anke, Diepstra, Arjan, Lugtenburg, Pieternella, Kersten, Marie José, Pals, Steven T, Veelken, Hendrik, Bovée, Judith, Cleven, Arjen, and Vermaat, Joost

Abstract

Introduction

Published
2019
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49. Acute Clinical Manifestation of Mesenteric Heterotopic Pancreatitis: A Pre- and Postoperative Confirmed Case

Author

M. de Kok, Bente, I. de Korte, Fleur, E. Perk, Lars, Terpstra, Valeska, Sven D. Mieog, J., and M. Zijta, Frank

Abstract

Heterotopic pancreas is a relatively uncommon congenital anomaly, defined as pancreatic tissue in ectopic sites without an anatomic and vascular continuity with the main body of the pancreas. We report the case of a 58-year-old woman who was admitted to the hospital with the clinical suspicion of a mild, acute pancreatitis. Computed tomography, magnetic resonance imaging, transabdominal ultrasound, and endoscopic ultrasound revealed a normal orthotopic pancreas and the suspicion of a large heterotopic pancreas in the small bowel mesentery with signs of acute inflammation. The diagnosis of mesenteric heterotopic pancreatitis was preoperatively confirmed by endoscopic ultrasound-guided fine-needle aspiration and consequently histologically established after surgical resection.

Published
2018
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50. Efficacy of EUS-guided keyhole biopsies in diagnosing subepithelial lesions of the upper gastrointestinal tract.

Author

Verhoeve S, Verloop C, Bruno M, Terpstra V, Van Driel L, Perk L, and Hol L

Abstract

Background and study aims Tissue acquisition is required for diagnosis of subepithelial lesions (SELs). However, obtaining adequate tissue remains challenging. This study investigated an EUS-guided technique using a forceps to create a channel and take multiple biopsies from the center of the lesion, therefore called endoscopic ultrasound-guided keyhole biopsy (EUS-KB). Patients and methods A retrospective cohort study was conducted in 56 patients with SELs in the upper gastrointestinal tract who were scheduled to undergo EUS-KB. The primary aim was to assess diagnostic yield, defined as the percentage of procedures where EUS-KB resulted in a definitive histopathological diagnosis. Furthermore, factors influencing diagnostic yield were investigated. Additional outcomes included technical success and adverse events. Results Technical success was achieved in 55 of 60 biopsies (91.7%). EUS-KB provided a diagnosis in 44 of 55 biopsies (80.0%), histology mostly showing gastrointestinal stromal tumor or leiomyoma. The diagnostic yield was not significantly influenced by the size or location of the SEL. Adverse events occurred in one patient (1.7%). Conclusions EUS-KB is a feasible and safe technique for obtaining a classifying diagnosis for SELs in the upper gastrointestinal tract. It could offer an alternative diagnostic modality, especially in lesions smaller than 20 mm., Competing Interests: Conflict of Interest M. J. Bruno has received research grants from Boston Scientific, Cook Medical, Pentax Medical, Interscope, Mylan, and 3M and acted as a consultant for Boston Scientific and Cook Medical. The remaining authors have no conflicts of interest to declare., (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).)

Published
2024
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