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4 results on '"Terrosu, P. F."'

1. Pravastatin vs Gemfibrozil in the Treatment of Primary Hypercholesterolaemia

Author

Malacco, E., Magni, Alberto, Scandiani, L., Casini, A., Albano, S., Ansuini, R., Biasion, T., Biffi, E., Bilardo, G., Boccuzzi, G., Breda, E., Buttafarro, A., Chella, P. S., Chieffo, C., Coletta, D., Coli, L., Colombo, L., Compagnoni, A., D’Amico, G., D’Ascia, C., De Gregori, M., De Joannon, U., Distante, R., Donadon, V., Donnini, P., Fallucca, F., Ferrari, L., Fesce, E., Formoso, L., Furlani, M., Galetta, F., Gianni, R., Giustina, G., Irace, L., Lipizer, A., Maggio, F., Magri, F., Mangiameli, S., Marasco, S., Marchetti, M., Marrazza, B., Melandri, F., Mondillo, G., Montagnani, M., Napoli, C., Neri, G. F., Orlandi, M., Pantaleoni, M., Papa, A., Perrella, G., Pileggi, V., Pilleri, G. P., Pittalis, M., Piva, M., Resta, F., Rodari, T., Savastano, A., Savona, M., Sensi, S., Sorrentino, F., Squadrito, S., Stocchiero, C., Stranieri, A., Susco, G., Tani, F., Tassone, F., Taverniti, R., Terrosu, P. F., Tirella, G., and Vicario, A.

Published
1994
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2. Pravastatin vsGemfibrozil in the Treatment of Primary Hypercholesterolaemia

Author

Malacco, E., Magni, Alberto, Scandiani, L., Casini, A., Albano, S., Ansuini, R., Biasion, T., Biffi, E., Bilardo, G., Boccuzzi, G., Breda, E., Buttafarro, A., Chella, P. S., Chieffo, C., Coletta, D., Coli, L., Colombo, L., Compagnoni, A., D’Amico, G., D’Ascia, C., De Gregori, M., De Joannon, U., Distante, R., Donadon, V., Donnini, P., Fallucca, F., Ferrari, L., Fesce, E., Formoso, L., Furlani, M., Galetta, F., Gianni, R., Giustina, G., Irace, L., Lipizer, A., Maggio, F., Magri, F., Mangiameli, S., Marasco, S., Marchetti, M., Marrazza, B., Melandri, F., Mondillo, G., Montagnani, M., Napoli, C., Neri, G. F., Orlandi, M., Pantaleoni, M., Papa, A., Perrella, G., Pileggi, V., Pilleri, G. P., Pittalis, M., Piva, M., Resta, F., Rodari, T., Savastano, A., Savona, M., Sensi, S., Sorrentino, F., Squadrito, S., Stocchiero, C., Stranieri, A., Susco, G., Tani, F., Tassone, F., Taverniti, R., Terrosu, P. F., Tirella, G., and Vicario, A.

Abstract

An increase in total and low density lipoprotein (LDL) cholesterol concentrations is related to the incidence of cardiovascular heart disease. The purpose of this study was to compare the efficacy and safety of pravastatin, an HMG-CoA reductase inhibitor, versus gemfibrozil, a fibrate, in the treatment of primary hypercholesterolaemia. 855 subjects (males and females, aged between 18 and 70 years) with total cholesterol (TC) concentrations > 240 mg/dl and triglyceride (TG) concentrations < 250 mg/dl were enrolled. After a pretreatment diet period, patients received either pravastatin 20 mg/day (659 patients) or gemfibrozil 1200 mg/day (196 patients). At the end of the 12-week treatment period, reductions in TC (−23%) and LDL-C (−31%) were noted in the pravastatin group. Gemfibrozil reduced TC by 16% and LDL by 20%. High density lipoprotein (HDL) cholesterol concentrations increased in a similar way in the two groups: pravastatin +10%, gemfibrozil+11%. Triglycerides decreased by 14% with pravastatin and by 22% with gemfibrozil. Pravastatin and gemfibrozil were both well tolerated. No significant adverse events or variations in laboratory parameters occurred during this study.

Published
1994
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3. [Urokinase in the therapy of spontaneous angina].

Author

Ibba GV, Terrosu PF, Innocenti P, Franceschino V, Contini GM, Delpini A, and Pes R

Subjects
Angina Pectoris diagnostic imaging, Coronary Angiography, Female, Humans, Injections, Intravenous, Male, Middle Aged, Urokinase-Type Plasminogen Activator administration & dosage, Angina Pectoris drug therapy, Urokinase-Type Plasminogen Activator therapeutic use
Abstract

Unlabelled: In an open non-comparative clinical study, 19 patients with spontaneous angina pectoris admitted to hospital with attacks lasting greater than 10 minutes, unresponsive to nitrate and/or calcium antagonist treatment, at least 2 ECG readings of raised (greater than or equal to 1.5 mm) or lowered (greater than or equal to 1 mm) ST segment not attributable to earlier AMI in the same area, were treated after the interruption of conventional treatment (mean 47 +/- 34.2 min) with 2 million IU endovenous UK in 15 mins followed by 1 million IU endovenous UK in 60 mins. Sixty minutes after UK administration was terminated, they were given a bolus of 5000 IU calcium heparin, followed by 1000 IU per hour for 2 days. Coronary angiography (Judkins technique) was performed before the start of UK treatment and 15, 30, 45, 60 and 75 minutes into it., Results: Basal coronarography showed only "multiple organic stenosis" in 5 out of the 19 patients, a more complex situation suggestive of thrombi in the coronary arteries in 14. Subsequent angiographies (mean 30 mins later) revealed coronarographic improvement in 11 out of the 19 (58%), or 11 out of 14 (78.5%) if we exclude those with simple stenosis. Angina attacks were significantly lower in the 8 days after UK treatment than in the week before it in terms of number (4 v. 1; p less than 0.01), global severity (7 v. 1.5; p less than 0.01) and global duration (45 v. 4.25 min; p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1989

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