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Your search keyword '"Tessaro, Fernando H. G."' showing total 7 results
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7 results on '"Tessaro, Fernando H. G."'

3. Cytokine and Adhesion Molecule Expression Induced by Different Strains of Staphylococcus aureus in Type 1 Diabetic Rats: Role of Insulin

Author

de Souza, Paula R. Knox, primary, Ferreira, Sabrina S., additional, Nunes, Fernanda P. B., additional, Casagrande, Felipe B., additional, Tessaro, Fernando H. G., additional, Silva, Mariana C. F., additional, Cruz, José Walber Miranda Costa, additional, Mamizuka, Elsa M., additional, and Martins, Joilson O., additional

Published
2019
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6. Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus

Author

Tessaro, Fernando H. G., Ayala, Thais S., and Martins, Joilson O.

Subjects
Article Subject, cardiovascular system, lipids (amino acids, peptides, and proteins), respiratory system
Abstract

The biosynthesis pathway of eicosanoids derived from arachidonic acid, such as prostaglandins and leukotrienes, relates to the pathophysiology of diabetes mellitus (DM). A better understanding of how lipid mediators modulate the inflammatory process may help recognize key factors underlying the progression of diabetes complications. Our review presents recent knowledge about eicosanoid synthesis and signaling in DM-related complications, and discusses eicosanoid-related target therapeutics.

Published
2015
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7. Single-cell RNA-seq of a soft-tissue sarcoma model reveals the critical role of tumor-expressed MIF in shaping macrophage heterogeneity.

Author

Tessaro FHG, Ko EY, De Simone M, Piras R, Broz MT, Goodridge HS, Balzer B, Shiao SL, and Guarnerio J

Subjects
Animals, Histocompatibility Antigens Class II genetics, Histocompatibility Antigens Class II metabolism, Macrophage Migration-Inhibitory Factors genetics, Mice, RNA-Seq, Tumor Microenvironment, Intramolecular Oxidoreductases metabolism, Macrophage Migration-Inhibitory Factors metabolism, Sarcoma genetics, Soft Tissue Neoplasms
Abstract

The standard of care is unsuccessful to treat recurrent and aggressive soft-tissue sarcomas. Interventions aimed at targeting components of the tumor microenvironment have shown promise for many solid tumors yet have been only marginally tested for sarcoma, partly because knowledge of the sarcoma microenvironment composition is limited. We employ single-cell RNA sequencing to characterize the immune composition of an undifferentiated pleiomorphic sarcoma mouse model, showing that macrophages in the sarcoma mass exhibit distinct activation states. Sarcoma cells use the pleiotropic cytokine macrophage migration inhibitory factor (MIF) to interact with macrophages expressing the CD74 receptor to switch macrophages' activation state and pro-tumorigenic potential. Blocking the expression of MIF in sarcoma cells favors the accumulation of macrophages with inflammatory and antigen-presenting profiles, hence reducing tumor growth. These data may pave the way for testing new therapies aimed at re-shaping the sarcoma microenvironment, in combination with the standard of care., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2022
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