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Copyright of Revista Estudos Feministas is the property of Revista Estudos Feministas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Latinoamericana de Hipertension is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Analyze sex hormone's influence during Chagas disease. Methods: Male and female BALB/c mice were divided into six groups, four experimental (sham, orchiectomized, orchiectomized and supplemented with estradiol, orchiectomized supplemented with testosterone, oophorectomized, oophorectomized and supplemented with estradiol, and oophorectomized and supplemented with testosterone), and two control (healthy and intraperitoneally with T. cruzi strain NINOA infected). Clinical data were recorded daily, parasitemia was evaluated using a Neubauer chamber during the infection, and heart histopathological analysis was performed using the paraffin embedding technique. To analyze parasitemia curves and the area under the parametric curves, two-way ANOVA test was performed to correlate groups' data. P-values < 0.05 were considered statistically significant. Results: Higher mortality rates, cardiomegaly, hepatomegaly, ascites, edema, higher parasitemia levels, more amastigote nests, and more severe inflammatory infiltrate were found in higher testosterone concentration mice, whereas in higher estradiol concentration groups, paresia, prostration, edema, and necrosis were found. Conclusions: Our results showed that testosterone increased infection severity, whereas estradiol had the opposite effect. This research improves the understanding of sex hormones' infuence upon this infection to contribute with the handling of Chagas' disease. [ABSTRACT FROM AUTHOR]

Copyright of Revista Chilena de Urologia is the property of Sociedad Chilena de Urologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Congenital adrenal hyperplasia is an autosomal recessive disorder caused by a defect in adrenal steroidogenesis. The non-classical variant begins at puberty and is manifested by menstrual irregularities, hirsutism, genital hyperpigmentation, clitoral hypertrophy, accelerated growth, and elevated levels of testosterone and other androgens. Individuals with these non-classical forms of the disease are born with normal-appearing genitalia and begin clinical manifestations with the steroidogenic stimulus characteristic of adolescence. CLINICAL CASE: A 16-year-old female patient seen at the endocrinology clinic for menstrual irregularities and hirsutism, menarche at 13 years of age with menstrual irregularities (oligomenorrhea) and recession of the frontal hairline, breast and pubic hair development grade 4 on the Tanner scale for both features. The diagnosis of late-onset 21-hydroxylase blockade (non-classical form) was established. Initial treatment consisted of metformin and cyproterone, with marked relieve of hyperandrogenism and correction of menstrual irregularities. CONCLUSIONS: Late-onset non-classical congenital adrenal hyperplasia is due to a homozygous point mutation of the CYP21A2 gene, which in turn is due to a coding error at position 281 of the 21-hydroxylase protein, consisting of a substitution of the amino acid valine for leucine and resulting in complete inactivation of both alleles of the enzyme. [ABSTRACT FROM AUTHOR]

A terapia de privação androgênica (TDA) é a base para redução de níveis séricos circulantes de andrógenos. Sua principal aplicabilidade é no tratamento do carcinoma de próstata, porém, tal terapia também vem sendo aplicada na castração química destinada a bloquear estímulos sexuais em paciente com doenças psiquiátricas que impossibilitem o convívio social. Esse documento tem o propósito de descrever as opções de castração química destinadas a reduzir os níveis séricos de testosterona total e livre disponíveis para uso.

Introdução: Desde a antiguidade, o homem utiliza as plantas para diferentes finalidades, inclusive para melhorar o desempenho físico. Porém, em anos recentes, a busca por fitoterápicos destinados a mimetizar o efeito anabolizante, com menor risco para a saúde e sem ser detectado no controle antidoping vem despertando o interesse de atletas e de usuários de academias. Objetivo: Avaliar quais são as drogas vegetais com possível atividade androgênica prescritas magistralmente na cidade do Rio de Janeiro. Método: Dados de 10.276 prescrições registradas no banco de dados de uma rede de farmácias de manipulação, localizada na cidade do Rio de Janeiro, entre o período de janeiro a dezembro de 2020, foram coletados e analisados. As formulações prescritas e aviadas continham Ajuga turkestanica, Cyanotis vaga, Eurycoma longifolia, Lepidium meyenii, Mucuna pruriens, Tribulus terrestris, Trigonella foenum-graecum e Withania somnifera. Resultados: A maioria das prescrições (57,0%) foi destinada a mulheres, receitadas por médicos especialistas em medicina ortomolecular (38,0%) e apenas 4,0% das receitas foram prescritas por nutricionistas. Quanto aos tipos de medicamentos, 8.116 prescrições (79,0%) eram formulações de associações de uma ou mais drogas vegetais anabolizantes com fármacos. M. pruriens foi a droga vegetal mais prescrita (29,0%), com ou sem associação. Conclusões: A maioria das plantas prescritas ainda não possui eficácia e segurança comprovadas quanto à ação anabolizante e, por isso, mais estudos clínicos são necessários, além da determinação das possíveis interações medicamentosas e efeitos adversos dessas drogas vegetais.

Contexto: los implantes de testosterona pueden lograr el incremento de los niveles séricos de testosterona. Objetivo: evaluar los beneficios y riesgos de los implantes de testosterona en mujeres, mediante una revisión sistemática de la literatura. Metodología: se realizó una revisión sistemática de la literatura acerca de los beneficios y riesgos del uso de los implantes de testosterona en mujeres. La búsqueda se hizo en diferentes bases de datos electrónicas (Medline, Central, Embase, entre otras), con términos de búsqueda libres y estandarizados. En los beneficios se consideró como desenlace primario la reactivación del deseo sexual, y en los riesgos la proporción de acné, spotting, clitoromegalia e hirsutismo. Resultados: se incluyeron 79 publicaciones. No se encontraron ensayos clínicos controlados aleatorizados que evaluaran los beneficios y riesgos de los implantes de testosterona en mujeres. En escasas publicaciones observacionales retrospectivas, el uso de implantes de testosterona en mujeres, se asoció con una mejoría en varios dominios de la función sexual y la angustia personal. Los datos acerca de la eficacia de seguridad a largo plazo son escasos y la calidad de la evidencia es baja. En los riesgos y efectos adversos comunes se encontró: acné, alopecia e hirsutismo, así como eritrocitosis (policitemia), extrusión, celulitis/infección y hematomas. Conclusiones: los beneficios de los implantes de testosterona en mujeres son superados por los riesgos, y la incidencia de efectos adversos irreversibles puede ser mucho más alta de lo que se ha informado. Es necesaria una estrecha vigilancia del uso racional de los implantes de testosterona en mujeres.

En 2003, el Comité Olímpico Internacional emitió reglas de elegibilidad para personas transgénero y, desde entonces, varios organismos deportivos han desarrollado sus propias reglas. Algunas federaciones aplican reglas basadas en la autodefinición del sexo, mientras que otras aplican reglas basadas en el sexo asignado al nacer o cuando se hizo la declaración de sexo. Este artículo profundiza el debate sobre la inclusión de las personas trans en el deporte a través de la presentación del caso de estudio del rugby, cuya federación internacional presentó, en 2020, reglas exclusivistas bajo el argumento de la competencia leal y la protección de la integridad física de las mujeres cisgénero. Se presentará un análisis crítico de los fundamentos de estas reglas y se discutirán las consecuencias de enfoques similares en la carrera deportiva de las personas trans. Como metodología se realizó un análisis documental crítico a las reglas de World Rugby y se realizaron entrevistas semiestructuradas a personas relacionadas con el universo deportivo en Portugal. Se observó que las reglas elaboradas crean una jerarquía entre los sexos binarios y entre las propias personas trans, se centran en medidas limitadas de comparación, como la fuerza de repetición única, y descartan factores como el aumento de la masa grasa después de la transición. Ante la ausencia de la posibilidad de seguir una carrera deportiva, existía una capacidad de agencia y compromiso en otros ámbitos que, al no ser la práctica de la competición como atletas, les permite alcanzar otras funciones importantes dentro del universo deportivo.

In 2003, the International Olympic Committee issued eligibility rules for transgender people, and since then, various sporting bodies have developed their own rules. Some federations apply rules based on self-definition of sex, while others apply rules based on the sex assigned at birth or when the sex claim was made. This article deepens the debate on the inclusion of trans people in sport through the presentation of the rugby's case study, whose international federation presented, in 2020, exclusivist rules under the argument of fair competition and protection of the physical integrity of cisgender women. A critical analysis of the foundations of these rules will be presented and the consequences of similar approaches in the sports career of trans people will be discussed. Regarding methodology, a critical document analysis on the World Rugby's rules was carried out and semi-structured interviews were conducted with people related to the sports universe in Portugal. It was observed that the elaborate rules create a hierarchy between the binary sexes and between trans people themselves, focus on limited measures of comparison such as single repetition strength, and rule out factors such as increased fat mass after transition. In the absence of the possibility of pursuing a sporting career, there was a capacity for agency and engagement in other areas that allows trans people to reach other important functions within the sports universe. [ABSTRACT FROM AUTHOR]

Introduction. Anxiety, mood- and stress-related behaviors are regulated by sex hormones in pregnant and non-pregnant women. Very scarce information exists about the role of sex steroids in pregnant women displaying high levels of anxiety. Objective. To determine sex hormones serum levels in pregnant women exhibiting high levels of anxiety symptoms. Method. The Hamilton Anxiety Rating Scale (HARS/ HAM-A) was used to assess the intensity of anxiety symptoms in third-trimester pregnant women. Two groups were included in the study, pregnant women exhibiting severe anxiety (ANX; HARS scores ≥ 25; n = 101) and healthy control subjects (CTRL; n = 40) displaying lower scores for anxiety (HARS scores ≤ 7). Estradiol (E2), progesterone (P4), and testosterone (T) serum levels were measured using a standard chemiluminescent immunoassay. Bivariate and partial correlations were performed to detect significant associations between groups, clinical measures, biochemical data, and HARS scores. Results. The anxiety group (ANX) showed an increase in E2 and T serum levels (p < .001) compared to CTRL. Conversely, significantly lower P4 levels were found in the symptomatic group (p < .001) as compared to the CTRL hormone values. The P4:E2 index was significantly reduced in pregnant women with high levels of anxiety (p < .001). Negative correlations between anxiety (HARS) scores, P4 serum levels (p = .02), and P4:E2 ratio (p = .04) were found in the symptomatic group. Conversely, T serum levels displayed a positive association (p = .001) with high levels of anxiety symptoms in the same group, after adjusting our data by clinical confounders. Discussion and conclusion. Serum levels of sex-steroid hormones are altered in pregnant women exhibiting severe anxiety. [ABSTRACT FROM AUTHOR]

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Resumo Fundamento: A deficiência de testosterona (DT) é uma condição prevalente em nosso meio e ainda muito negligenciada. A hipertensão arterial (HA) é um de seus possíveis fatores associados. Objetivos: Determinar a prevalência de DT em uma população masculina hipertensa e os fatores associados à sua ocorrência, como idade, tempo de diagnóstico de HA, número de classes de anti-hipertensivos, índice de massa corporal (IMC), diabetes, dislipidemia, doença renal crônica (DRC), sintomas positivos de DT (questionário ADAM positivo) e uso de espironolactona. Métodos: Estudo transversal com aplicação do questionário ADAM, e avaliação de dados bioquímicos, clínicos e antropométricos. Os pacientes foram estratificados em grupos de DT e testosterona normal. As variáveis categóricas foram comparadas pelo teste do qui-quadrado e as variáveis contínuas pelo teste de Mann-Witney; as variáveis com significância (p

El hueso es un tejido dinámico, que se encuentra en constante adaptación durante la vida de los vertebrados con el fin de alcanzar tamaño, forma, preservar la integridad estructural del esqueleto y regular la homeostasis mineral. Su desarrollo durante la infancia es determinante para alcanzar la estatura, así como la resistencia a fracturas en edad avanzada. Las hormonas sexuales juegan un papel importante en el remodelado óseo, tanto en hombres como en mujeres y las alteraciones en los perfiles hormonales pueden conducir al desarrollo de enfermedades asociadas con el metabolismo del hueso. En mujeres, la deficiencia de estrógenos durante la menopausia es una de las principales causas de osteoporosis, mientras que en hombres los andrógenos pueden influir en la salud ósea al unirse directamente a los receptores de andrógenos o indirectamente a receptores de estrógenos. En esta revisión se explora el papel y los efectos de las hormonas sexuales sobre el metabolismo óseo, las vías de señalización implicadas y los efectos que pueden conducir al desarrollo de enfermedades como la osteoporosis. [ABSTRACT FROM AUTHOR]

Objetivo: descrever os principais efeitos anabólicos e colaterais provenientes do uso de esteroides anabolizantes (EA) nos praticantes de exercício físico. Materiais e Métodos: trata-se de uma revisão sistemática. A identificação dos trabalhos científicos foi realizada a partir dos seguintes descritores: agentes anabolizantes, testosterona, exercício físico, efeito adverso. Também foram pesquisados esses termos nos idiomas inglês e espanhol. O processo de seleção excluiu artigos duplicados, a partir da leitura dos títulos e resumos. Após a seleção, no processo de elegibilidade foram excluídos artigos com problema no desenho, no seguimento e intervenção inadequada. Assim, foram selecionados apenas artigos que passaram no processo de análise qualitativa, se for esse o caso. Resultados: dentre 125 artigos identificados, apenas 14 artigos foram selecionados, somando-se 26.131 indivíduos envolvidos nos estudos. A maior parte dos estudos foi do tipo transversal cujos dados foram obtidos por meio da aplicação de questionários. O uso de EA variou entre 2,3% e 31% no público estudado. Nota-se ampla predominância do sexo masculino, representando 87% dos casos. O uso de EA predominou entre pessoas com idade entre 20 a 29 anos (42,8%), com ensino médio completo (46,7%) e com mais de três anos na prática de musculação (44,1%). A acne foi identificada entre 42,9% e 63,4% dos usuários, oscilação na libido entre 14,3% e 48,7%, disfunção sexual em 24,6% e variações de humor em até 42,8% dos usuários. Entre os EAs mais utilizados, destacara-se Deca Durabolin®, Hemogenin®, Testosteron®, Estanozolol® e Durateston®. Conclusão: a prevalência do uso de EAs é maior entre pessoas de 20 a 29 anos com ensino médio completo e com mais de 3 anos na prática de musculação. Dentre os efeitos colaterais, identificaram-se a acne, oscilação na libido, com usuários declarando um aumento no desejo sexual.

Background: Crocodile farming aims to produce high-quality skins from captive crocodilians. Captivity usually exposes the animals to stressful conditions, resulting in increased serum corticosterone (CORT) levels that correlate negatively with those of sex hormones and reproductive success. Objective: To evaluate serum concentrations of CORT and sex hormones and their relationship in farmed Morelet's crocodiles (Crocodylus moreletii) during the non-breeding (NBS) and breeding (BS) seasons. Methods: The study included 59 adult crocodiles (29 females and 30 males). One blood sample was collected in NBS (n=31) and BS (n=28) from each crocodile to determine serum concentrations of CORT, estradiol (E2), progesterone (P4), and testosterone (T). Crocodiles were kept in mixed-sex groups and were fed once or twice a week throughout the study. Results: In females, CORT was higher in NBS (p<0.05) but had no correlation with E2 or P4 in any season (p>0.05). In males, CORT was similar in NBS and BS (p>0.05) and had no correlation with T (p>0.5). Conclusion: The CORT levels had no effect on sex hormones. This could be explained by low CORT levels resulting from farming conditions where the animals were not exposed to severe or chronic stress. [ABSTRACT FROM AUTHOR]

Copyright of Health & Society is the property of Instituto de Ensino e Pesquisa Periodicojs and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Health & Society is the property of Instituto de Ensino e Pesquisa Periodicojs and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

La correcta aproximación clínica a un amplio grupo de situaciones depende en gran medida de la disponibilidad de resultados analíticos de esteroides sexuales que sean exactos y reproducibles, obtenidos con métodos con la especificidad y sensibilidad analíticas adecuadas. En este sentido, los inmunoanálisis quimioluminiscentes actuales presentan limitaciones analíticas con repercusiones clínicas importantes. El documento de posicionamiento revisa el estado actual en la estandarización de los métodos de medida de estradiol y testosterona y su repercusión en distintas situaciones clínicas. Se incluye asimismo una serie de recomendaciones a seguir para introducir en los sistemas nacionales de salud los análisis de esteroides por espectrometría de masas, metodología recomendada desde hace más de una década por las sociedades internacionales.

Os hormônios testosterona e cortisol possuem ação antagônica no organismo, sendo a razão testosterona/cortisol usada para apreciar o estado anabólico/catabólico dos jogadores de futebol. Buscou-se avaliar as variações nas concentrações desses hormônios ao longo de uma temporada competitiva de alta densidade. Participaram do estudo 23 atletas do sexo masculino de uma equipe da primeira divisão do futebol nacional no contexto da Copa do Mundo, divididos em titulares e reservas. Coletou-se 7 amostras de sangue durante o calendário de jogos (M0 a M6). Para a análise estatística utilizou-se a ANOVA two way para medidas repetidas seguida do post hoc de Tukey. Obteve-se uma matriz de correlação entre as variáveis através do coeficiente de Pearson. O nível de significância foi de p

Oxytocin and vasopressin share a similar chemical structure but have different functions. Both hormones are produced in different brain areas, are transported through the hypophyseal portal system, pass to the anterior hypophysis, and released to reach their target organs. These hormones also act as neuromodulators, where its receptors are found in the lateral septum, the middle amygdala, the hippocampus, the hypothalamus, and the brain stem. These brain structures regulate socio-sexual behaviors in vertebrates. Moreover, the oxytocinergic and the vasopressin systems are sexually different. The sexual steroids promote oxytocin release and the oxytocin receptor synthesis, as well as promoting or inhibiting vasopressin release and its receptor genetic transcription. Both neuropeptides are involved in social recognition, male-female pair bonding, aggression, and cognition. Furthermore, the disruption or malfunctioning of the oxytocin and vasopressin systems adds to the causes of some psychiatric disorders like depression, schizophrenia, autism, and borderline personality. [ABSTRACT FROM AUTHOR]

Copyright of Advances in Laboratory Medicine / Avances en Medicina de Laboratorio is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Brasileira de Medicina do Esporte is the property of Redprint Editora Ltda. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Revista Brasileira de Prescrição e Fisiologia do Exercício is the property of Instituto Brasileiro de Pesquisa e Ensino em Fisiologia do Exercicio and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Brasileira de Medicina do Esporte is the property of Redprint Editora Ltda. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction and Objectives: Chronic obstructive pulmonary disease (COPD) frequently coexists with other comorbidities, including hypogonadism. However, the association between COPD severity and hypogonadism remains controversial. This study aimed to evaluate this association and compare the clinical characteristics of hypogonadal and eugonadal COPD patients., Materials and Methods: A cross-sectional study including men with stable COPD was performed. Hypogonadism was diagnosed based on the presence of symptoms, according to the Androgen Deficiency in Aging Males questionnaire, and a total testosterone deficit (<300ng/dL). COPD severity was classified according to the Spanish COPD guideline risk classification. A multivariate logistic regression analysis was performed in order to evaluate the relationship between COPD severity and hypogonadism., Results: 134 subjects were recruited. The prevalence of hypogonadism was higher in severe COPD than in mild COPD, with a prevalence ratio of 1.8 (p=0.007). An increased odds of hypogonadism was observed in severe COPD subjects (OR 2.60, 95% CI 1.23-5.48, p=0.012) independent of age, body mass index, cardiovascular disease, and chronic renal failure. Hypogonadal COPD patients exhibited lower percentage levels of FVC and FEV 1 and a higher degree of dyspnea than compared to eugonadal COPD patients., Conclusion: Patients with severe COPD had a higher prevalence of hypogonadism compared to those with mild COPD. Additionally, severe COPD was identified as an independent risk factor for hypogonadism. These findings suggest that hypogonadism should be evaluated in patients with COPD, particularly in those with severe disease., (Copyright © 2024 Elsevier España, S.L.U. All rights reserved.)

Objective: This study aims to investigate the relationship between the presence of late-onset hypogonadism (LOH) syndrome in men and alterations in testicular echogenicity in a rural population sample., Materials and Methods: Prospective observational cohort study in which men between 45 and 75 years old from Villarta de San Juan area (Ciudad Real) were included. In order to determine the incidence of HIT, each patient was administered the AMSS test, a blood test to determine the concentration of testosterone, and a bilateral testicular ultrasound was performed., Results: 287 patients were included in the study. The diagnosis of LOH syndrome was established in 9.76% of them. 154 bilateral testicular ultrasounds were performed in which their testicular echogenicity patterns were evaluated. In 72.7% of the cases, alterations could be described in accordance with the standards proposed by the European Academy of Andrology of the year 2022. Testicular echogenicity evaluated by ultrasound demonstrated a sensitivity of 72.7%, a specificity of 78.8%, a negative predictive value of 94.5% and a positive predictive value of 36.4%, for the diagnosis of LOH., Conclusions: The determination of testicular echogenicity in patients with suspected LOH syndrome showed much greater specificity than the AMSS test and a similar negative predictive value. Based on its innocuousness and the fact that it is a relatively simple examination from a technical point of view, it could be postulated as a diagnostic tool to be taken into account in the identification of this syndrome., (Copyright © 2024 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.)

Background: Hypogonadism is a common finding of chronic obstructive pulmonary disease (COPD). However, the prevalence of hypogonadism in COPD varies among studies. The aim of this study was to determine and compare the prevalence of hypogonadism in men with and without COPD., Methods: We conducted a cross-sectional study with 134 patients with stable COPD and 70 age-matched men with non-COPD. Hypogonadism was defined by the presence of symptoms according to the Androgen Deficiency in Aging Males questionnaire, along with total testosterone deficiency (<300ng/dL)., Results: Patients had a mean age of 68 years (SD, 6), a body mass index of 28kg/m 2 (SD, 6), and 17% were current smokers. The prevalence of hypogonadism was 41.8% in COPD men (N=56, 95%CI, 33-51) and 10.0% in non-COPD men (N=7, 95%CI, 4-20), with a prevalence ratio of 4.2 (95%CI, 2.0-8.7, p<0.001). The prevalence of low total testosterone concentrations (<300ng/dL) were significantly higher in COPD patients vs the control group (47.0% vs 15.7%, p=<0.001). In the COPD group, 89.3% of patients had hypogonadotropic hypogonadism and 10.7%, hypergonadotropic hypogonadism. The prevalence of hypogonadism was higher in severe vs non-severe COPD patients (55.8% vs 35.2%; p=0.024)., Conclusions: The prevalence of hypogonadism was high and greater in COPD vs non-COPD men. This study suggests that COPD patients should be screened for hypogonadism., (Copyright © 2024 SEEN and SED. Published by Elsevier España, S.L.U. All rights reserved.)

Diversos estudios relacionan la concentración plasmática de testosterona con un comportamiento agresivo del animal. En ellos se han estudiado diferentes especies animales, pero se desconoce cómo es esta relación en el toro de lidia, perteneciente a una raza bovina singular por su selección etológica hacia la agresividad. En este trabajo se analizó de forma objetiva el comportamiento en el ruedo de 302 machos adultos de la raza bovina de lidia. Se registraron 33 parámetros etológicos, el número y gravedad de las caídas experimentadas por el animal y el tiempo de las cuatro fases del espectáculo, para correlacionar dicha información con la concentración plasmática de testosterona. Los resultados mostraron diferencias en la media de concentración plasmática de testosterona entre ganaderías y entre las líneas genéticas de procedencia estudiadas en la muestra. Igualmente se constata una correlación positiva entre la concentración de testosterona y un grupo de ocho parámetros etológicos, que señalan ejercicio físico del animal; por otro lado se observó una correlación negativa con los parámetros etológicos: “sale suelto”, “querencia” y “tardea”, sinónimos de falta de casta, lo que podría indicar una correlación positiva entre la testosterona y la agresividad, como indica la bibliografía.

Steroids play an essential role in coordinating the activities of the hypothalamic-pitu-itary-gonad axis and their activity in controlling multiple processes, including mating and reproduction. The current study described the serum levels of testosterone (T), estradiol (E2), and cortisol in specimens older than two years of Pseudoplatystoma metaense x Leiarius marmoratus in captive conditions. Eight samplings were carried out from January to October. Nine hybrid individuals were used between males and females (4: 5, respectively), with 7 ± 2 individuals being randomly selected for each sampling. The blood samples were processed and analyzed every 40-45 days during the experimental period. The levels of T in males (0.65 ng/ml) and E2 in females (0.88 ng/ml) presented the highest peaks during the months of the most significant rainfall in the region (June -July) that triggered the beginning of the reproductive season. On the one hand, E2 levels in females are possibly associated with ovarian maturation and aromatase activity, while males showed decreases of 0.1 ng/ml from June to July; and a maximum increase of 0.7 ng/ml for October. On the other hand, cortisol levels increased towards the breeding season, being higher in females (18.8 - 25.4 ng/ml). This may indicate that despite high cortisol concentrations, steroid production was not inhibited. [ABSTRACT FROM AUTHOR]

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El hipogonadismo debe sospecharse siempre en un paciente con disfunción sexual eréctil y principalmente cuando existan: disminución de las fantasías sexuales, de la libido y/o de las erecciones espontáneas, y un trastorno metabólico presente (obesidad, síndrome metabólico [SM] o diabetes mellitus tipo 2). La mayor edad es también un factor de riesgo para tener testosterona baja.

Introduction: precocious puberty (PP) is characterized by the development of secondary sexual characteristics prematurely. There are different causes of PP. The objective of this article is to describe how inadvertent testosterone exposure can cause peripheral PP. Clinical case: five-year-old male with macrogenitosomia and increased growth rate (20 cm/year). Physical examination: height 135 cm (80th percentile), facial acne, and increased muscle development; in genitalia, pubarche grade II, penis length 12 cm (Tanner 5), testicles 4 cm3 (Tanner 2). Bone age of 8.5 years. In laboratory studies, it was highlighted that serum testosterone levels were 98 ng/dL (normal < 5 ng/dL). In directed questioning, the father refers to the use of gel containing testosterone for aesthetic purposes, and close contact with his children. With all this information, diagnosis of peripheral PP was concluded. The gel was suspended, observing a decrease in testosterone to 60 ng/dL at 10 days. Conclusion: testosterone-containing products used topically by parents can cause peripheral PP in children, which is characterized by virilization, with growth of external genitalia and accelerated skeletal maturation. [ABSTRACT FROM AUTHOR]

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O consumo de suplementos alimentares, como whey protein (WP) e de esteróides androgênicos anabolizantes (EAA) tem se tornado evidente entre atletas e praticantes de exercícios físicos. Objetivou-se analisar os efeitos da suplementação de WP e da administração de uma dose suprafisiológica de testosterona, associadas ou não, em ratos machos Wistar submetidos ao nado forçado. Foram utilizados 40 ratos, divididos em: Grupo controle (G1), Grupo WP (G2), Grupo WP + testosterona (G3) e Grupo testosterona (G4). Os quatro grupos realizaram nado forçado por 30 minutos diários, cinco vezes por semana. Em todos os grupos analisou-se o peso inicial e final dos animais, o peso final do coração e do quadríceps, os parâmetros bioquímicos (glicose, colesterol total e frações, triglicerídeos, albumina, proteínas totais, creatinina, ureia, alanina aminotransferase, aspartato aminotransferase e creatina quinase), a curva glicêmica e a dosagem de glicogênio hepático e muscular. A suplementação com WP associada ou não a administração de testosterona, não promoveu alterações no peso corporal e do coração, fígado e quadríceps dos animais, nem alterou a tolerância a glicose e o armazenamento de glicogênio hepático ou muscular, porém os grupos que receberam testosterona apresentaram valores mais baixos de glicemia. A suplementação com WP causou uma redução no consumo de ração, já a testosterona isolada não alterou a ingesta. As funções hepática e renal não foram alteradas por nenhuma das substâncias, porém houve tendência de piora do perfil lipídico motivada pela administração de testosterona e o esteróide associado a suplementação parece diminuir a lesão muscular provocada pelo exercício.

RESUMEN Objetivo: Revisión en la literatura de la relación entre la testosterona y la conducta suicida, enfatizando la importancia del abordaje multidisciplinar en la transexualidad. Caso clínico: Varón (mujer biológica) de 33 años, con antecedentes psiquiátricos de un ingreso en 2010, diagnosticado de Trastorno depresivo NE y Trastorno de la personalidad NE. Posteriormente, realizó seguimiento irregular en consultas de Psiquiatría hasta abandono voluntario. En 2019, solicita nueva consulta para valoración de disforia de género. Refiere no sentirse identificado con su cuerpo y sentir rechazo hacia sus caracteres sexuales. Tras confirmación de ausencia de contraindicaciones, se realiza interconsulta al Servicio de Endocrinología, pautando tratamiento hormonal cruzado. A los 4 días de iniciar el tratamiento con testosterona, el paciente realiza un intento autolítico. No existía historia de intentos autolíticos ni ideación suicida previa, manteniendo estabilidad anímica en visitas anteriores. Resultados y conclusiones: los estudios publicados sugieren el efecto de la testosterona sobre la agresividad, la dominancia, la impulsividad y la líbido; así como sugieren una asociación entre la testosterona y la conducta suicida. Este hecho apoya la necesidad del seguimiento multidisciplinar del proceso de la transexualidad, siendo esencial el abordaje por parte de los profesionales de la Salud Mental.

Introducción: los niveles de vitamina D (VD) plasmática se han investigado sobre todo en mujeres, no obstante también son relevantes en hombres, y no sólo en relación al estado de salud ósea. Un estudio previo realizado hace dos décadas en una pequeña muestra de hombres y mujeres uruguayos reveló serias deficiencias de VD. Por otra parte, el magnesio posee importantes efectos no solo relacionados a los niveles de VD, también afecta el hueso directa e indirectamente. Objetivos: analizar posibles interrelaciones entre valores de VD plasmática, testosterona plasmática, densitometría ósea, y otros parámetros en una población de jóvenes varones uruguayos. Métodos: durante julio-agosto de 2015, cien hombres uruguayos afiliados al sistema prepago de salud fueron invitados a participar en nuestra Unidad de Metabolismo Fosfocálcico, para ser estudiados con técnicas de antropometría, laboratorio y densitométricas. Los datos colectados fueron analizados estadísticamente. Resultados: los hombres estudiados mostraron bajos niveles de VD plasmática (96% insuficientes-deficientes), que no mostraron correlaciones significativas con ninguno de los parámetros estudiados. El magnesio plasmático se correlacionó significativa e inversamente con los z-scores densitométricos, lo que fue más intenso en hombres con sobrepeso y con VD ≥15 ng/ml. Conclusiones: a pesar de lo pequeño de la muestra, los resultados confirman la presencia de bajos niveles de VD en hombres aparentemente saludables. Los hallazgos dan razones para pensar en posibles recomendaciones para mejorar el espectro preventivo enfocado en osteoporosis y cáncer colorrectal.

Resumo Este artigo analisa a percepção de homens usuários de testosterona acerca dos efeitos adversos no uso do hormônio, a fim de refletir sobre a eficácia e o alcance de ações em saúde voltadas para essa prática. Os dados empíricos foram obtidos a partir de 21 relatos de história de vida de homens que utilizam a testosterona, com ou sem acompanhamento médico, de perfil variado, coletados em 2016 majoritariamente no Rio de Janeiro. A discussão se apoia nos estudos de gênero e de masculinidades para argumentar como os homens interpretam os impactos do uso da testosterona a partir de uma valorização de características masculinas associadas a um ideal normalizador de masculinidade. Os resultados apontam uma percepção generalizada no campo de que o hormônio causa pouco ou nenhum mal, através de um processo de invisibilização ou ressignificação dos efeitos potencialmente negativos. Além disso, há um movimento de deslocamento dos problemas associados ao uso a personagens estereotipadas, num processo de desresponsabilização de si e reafirmação de atributos de um ideal de masculinidade. Com isso, busca-se contribuir para a construção de ações em saúde mais adequadas ao cotidiano dos usuários e, portanto, mais eficazes.

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