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1. Translocator protein (TSPO) genotype does not change cerebrospinal fluid levels of glial activation, axonal and synaptic damage markers in early Alzheimer’s disease

Author

Gouilly, Dominique, Vrillon, Agathe, Bertrand, Elsa, Goubeaud, Marie, Catala, Hélène, Germain, Johanne, Ainaoui, Nadéra, Rafiq, Marie, Nogueira, Leonor, Mouton-Liger, François, Planton, Mélanie, Salabert, Anne-Sophie, Hitzel, Anne, Méligne, Déborah, Jasse, Laurence, Sarton, Benjamine, Silva, Stein, Lemesle, Béatrice, Péran, Patrice, Payoux, Pierre, Thalamas, Claire, Paquet, Claire, and Pariente, Jérémie

Published
2024
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2. Overt and covert paths for sound in the auditory system of mammals

Author

Auriol, Bernard M., Auriol, Benjamin, Béard, Jérome, Bibé, Bernard, Broto, Jean-Marc, Descouens, Didier, Durand, Lise J. S., Florens, Jean-Pierre, Garcia, Frédérick, Joiner, Elizabeth G., Libes, Bernard, Pergent, Philippe, Ruiz, Robert, and Thalamas, Claire

Subjects
Quantitative Biology - Tissues and Organs
Abstract

Current scientific consensus holds that sound is transmitted, solely mechanically, from the tympanum to the cochlea via ossicles. But this theory does not explain the hearing extreme quality regarding high frequencies in mammals. So, we propose a bioelectronic pathway (the covert path) that is complementary to the overt path.. We demonstrate experimentally that the tympanum produces piezoelectric potentials isochronous to acoustic vibrations thanks to its collagen fibers and that their amplitude increases along with the frequency and level of the vibrations. This finding supports the existence of an electrical pathway, specialized in transmitting high-frequency sounds, that works in unison with the mechanical pathway. A bio-organic triode, similar to a field effect transistor, is the key mechanism of our hypothesized pathway. We present evidence that any deficiency along this pathway produces hearing impairment. By augmenting the classical theory of sound transmission, our discovery offers new perspectives for research into both normal and pathological audition and may contribute to an understanding of genetic and physiological problems of hearing., Comment: preprint

Published
2019

3. Successful Thrombectomy Improves Functional Outcome in Tandem Occlusions with a Large Ischemic Core

Author

Lapergue, Bertrand, Wang, Adrien, Consoli, Arturo, Coskun, Oguzhan, Maria, Federico Di, Pizzuto, Silvia, Sgreccia, Alessandro, Benoit, Charline, Gorza, Lucas, Weisenburger-Lile, David, Jabeur, Waliyde, Maia, Tchikviladze, Evrard, Serge, Rodesch, Georges, Blanc, Raphaël, Obadia, Michael, Desilles, Jean-Philippe, Piotin, Michel, Seners, Pierre, Smajda, Stanislas, Escalard, Simon, Maier, Benjamin, Sabben, Candice, Redjem, Hocine, Mikaelmazhigi, Adwan, Grace, Delvoye, François, Raaisi, Amira Al, Boisseau, William, Eker, Omer, Cho, Tae-Hee, Derex, Laurent, Fontaine, Julia, Mechtouff, Laura, Nighoghossian, Norbert, Ong, Elodie, Rascle, Lucie, Riva, Roberto, Turjman, Françis, Laubacher, Morgane, Beyragued, Mehdi, Berthezene, Yves, Hermier, Marc, Roxanna, Ameli, Bani-Sadr, Alexandre, Filip, Andrea, Cappucci, Matteo, Bourcier, Romain, Duport, Benjamin Daumas, Alexandre, Pierre Louis, Lenoble, Cédric, Hubertdesal, Gaalon, Solène De, Guillon, Benoît, Preterre, Cécile, Tessier, Guillaume, Lionnet, Arthur, Gory, Benjamin, Humbertjean-Selton, Lisa, Anxionnat, René, Derelle, Anne-Laure, Liao, Liang, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Mione, Gioia, Lacour, Jean-Christophe, Douarinou, Marian, Micard, Emilien, Chen, Bailiang, Audibert, Gérard, Masson, Agnès, Alb, Lionel, Beaumont, Marine, Tabarna, Adriana, Voicu, Marcela, Barthel, Grégoire, Podar, Iona, Brezeanu, Madalina, Reitter, Marie, Zhu, François, Marnat, Gaultier, Liegey, Jean-Sébastien, Briau, Pierre, Papillon, Lisa, Sibon, Igor, Barreau, Xavier, Papaxanthos, Jean, Berge, Jérome, Debruxelles, Sabrina, Olindo, Stephane, Poli, Mathilde, Renou, Pauline, Sagnier, Sharmila, Tourdias, Thomas, Courret, Thomas, Lucas, Ludovic, Milnerowicz, Malgorzata, Dargazanli, Cyril, Costalat, Vincent, Mourand, Isabelle, Arquizan, Caroline, Corti, Lucas, Adrien, Schiphorst, Ter, Federico, Cagnazzo, Derraz, Imad, Mahmoudi, Mehdi, Lefevre, Pierre-Henri, Gascou, Grégory, Spelle, Laurent, Caroff, Jildaz, Denier, Christian, Chalumeau, Vanessa, Mihalea, Cristian, Nicolaslegris, Ozanne, Augustin, Ikka, Leon, Chassin, Olivier, Gallas, Sophie, Venditti, Laura, Marianasarov, Cortese, Jonathan, Ferre, Jean-Christophe, Vannier, Stephane, Ronziere, Thomas, Veronica Lassalle, Maria, Gauvrit, Jean-Yves, Tracol, Clément, Boustia, Abdelghani Fakhreddine, Malrain, Cécile, Beaufreton, Edouard, Lapotre, Thibault, Alias, Quentin, Hissier, Julien, Guillen, Maud, Eugene, François, Chivot, Cyril, Courselle, Audrey, Ouin, Elisa, Lamy, Chantal, Delaforge, Kevin, Fernandez, Manuel, Vial, Jérémie, Laferte, Quentin, Desdoit, Xavier, Timsit, Serge, Jourdain, Aurore, Gentric, Jean-Christophe, Ognard, Julien, Viakhireva, Irina, Coris, Jordan, Prud'hon, Sabine, Merrien, François-Mathias, Marechal, Denis, Bruguet, Marie, Rousseau, Pierre Yves, Goas, Philippe, Boulanger, Marion, Touze, Emmanuel, Vivien, Denis, Barbier, Charlotte, Schneckenburger, Romain, Salaris, Fabrizio, Cogez, Julien, Guettier, Sophie, Porte, Estelle La, Bouchart, Jean, Mounayer, Charbel, Rouchaud, Aymeric, Saleme, Suzana, Forestier, Géraud, Clarencon, Frédéric, Rosso, Charlotte, Leder, Sara, Baronnet, Flore, Crozier, Sophie, Leger, Anne, Premat, Kevin, Eimad, Shotar, Lenck, Stéphanie, Sourour, Nader, Bottin, Laure, Ghazanfari, Sam, Yger, Marion, Alamowitch, Sonia, Delorme, Stephen, Wittwer, Aymeric, Vassilev, Christine, Naggara, Olivier, Turc, Guillaume, Hassen, Wagih Ben, Kerleroux, Basile, Trystram, Denis, Rodriguez-Regent, Christine, Ozkul-Wermester, Ozlem, Papagiannaki, Chrysanthi, Massardier, Evelyne, Triquenot, Aude, Lefebvre, Margaux, Burel, Julien, Viguier, Alain, Cognard, Christophe, Januel, Anne Christine, Albucher, Jean-François, Calviere, Lionel, Olivot, Jean-Marc, Darcourt, Jean, Raposo, Nicolas, Bonneville, Fabrice, Bellanger, Guillaume, Fontaine, Louis, Tall, Philippe, Thalamas, Claire, Geerearts, Thomas, Grepon, Antoine Faurie, Bourdain, Frédéric, Bernady, Patricia, Ballan, Guillaume, Bannier, Stéphanie, Ellie, Emmanuel, Flabeau, Olivier, Potenza, Julia, Soulages, Antoine, Lagoarde-Segot, Laurent, Cailliez, Hélène, Veunac, Louis, Higue, David, Lebras, Anthony, Adam, Sarah, Pegat, Benoit, Guen, Arnaud Le, Chedeville, François, Jouan, Jérémy, Demasles, Stéphanie, Richter, Johann Sebastian, Thierry Barroso, Bruno, Dahan, Camille, Gonnet, Alexis, Hubrecht, Régis, Lepine, Zoé, Castagnet, Hélène, Marasescu, Raluca, Heck, Olivier, Cuisenier, Pauline, Detante, Olivier, Wiki, Isabelle Favre, Bonaz, Clémentine, Garambois, Katia, Legris, Loic, Kastler, Adrian, Boubagra, Kamel, Berthet, Corentin, Charara, Stéphane, Wolff, Valérie, Pop, Raoul, Quenardelle, Véronique, Lauer, Valérie, Pierre-Paul, Irène, Roxanagheoca, Trzeciak, Malwina, Moulin, Solène, Tuan, Hua Vi, Pagano, Paolo, Doucet, Alexandre, Gelmini, Christophe, Manceau, Pierrefrançois, Paiusan, Laurentiu, Serre, Isabelle, Soize, Sébastien, Phuong Nguyen, Thi Ngoc, Sahnoun, Maher, Caucheteux, Nathalie, Ferrier, Anna, Zerroug, Abderrahim, Moreno, Ricardo, Chabert, Emmanuel, Lteif, Elie, Paulineparis, Bourgois, Nathalie, Raquin, Marie, Pasco-Papon, Anne, Girot, Jean Baptiste, Lecluse, Alderic, Godard, Sophie, L'allinec, Vincent, Janot, Kevin, Bibi, Richard, Gaudron, Marie, Bretonniere, Arnaud, Annan, Mariam, Ifergan, Héloïse, Boulouis, Grégoire, Pasi, Marco, Debiais, Séverine, Molinier, Elisabeth, Wietrich, Anthony, Ruche, Valérie, Lavandier, Karine, Bejot, Yannick, Lemogne, Brivale, Ricolfi, Fédéric, Baptiste, Laura, Thouant, Pierre, Duloquin, Gaulthier, Olivier Comby, Pierre, Charbonnier, Guillaume, Bonnet, Louise, Raybaud, Nicolas, Bouamra, Benjamin, Moulin, Thierry, Biondi, Alessandra, Finitsis, Stephanos, and Mazighi, Mikael

Published
2023
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4. Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: A prospective cohort study

Author

Pires Da Silva, Julie, Wargny, Matthieu, Raffin, Jérémy, Croyal, Mikaël, Duparc, Thibaut, Combes, Guillaume, Genoux, Annelise, Perret, Bertrand, Vellas, Bruno, Guyonnet, Sophie, Thalamas, Claire, Langin, Dominique, Moro, Cédric, Viguerie, Nathalie, Rolland, Yves, Barreto, Philipe de Souto, Cariou, Bertrand, and Martinez, Laurent O.

Published
2023
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5. Oxycodone or Higher Dose of Levodopa for the Treatment of Parkinsonian Central Pain: OXYDOPA Trial

Author

Brefel‐Courbon, Christine, primary, Harroch, Estelle, additional, Marques, Ana, additional, Devos, David, additional, Thalamas, Claire, additional, Rousseau, Vanessa, additional, Ory‐Magne, Fabienne, additional, Fabbri, Margherita, additional, Maltête, David, additional, Rouaud, Tiphaine, additional, Drapier, Sophie, additional, Tir, Melissa, additional, Thobois, Stephane, additional, Salhi, Hayet, additional, Corvol, Jean Christophe, additional, Castelnovo, Giovanni, additional, Lagha‐Boukbiza, Ouhaid, additional, Fluchère, Fréderique, additional, Frismand, Solene, additional, Ansquer, Solene, additional, Sommet, Agnes, additional, and Rascol, Olivier, additional

Published
2024
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6. Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Garibaldi, Brian T., Albertson, Timothy E., Sandrock, Christian, Lee, Janet S., Looney, Mark R., Tapson, Victor F., Wiysonge, Charles Shey, Velarde, Luis Humberto Anaya, Backenroth, Daniel, Bhushanan, Jisha, Brandenburg, Börries, Cárdenas, Vicky, Chen, Bohang, Chen, Fei, Chetty, Polan, Chu, Pei-Ling, Cooper, Kimberly, Custers, Jerome, Delanghe, Hilde, Duca, Anna, Henrick, Tracy, Juraszek, Jarek, Nalpas, Catherine, Peeters, Monika, Pinheiro, Jose, Roels, Sanne, Ryser, Martin F., Salas, Jose, Santoro Matias, Samantha, Scheys, Ilse, Shetty, Pallavi, Shukarev, Georgi, Stoddard, Jeffrey, Talloen, Willem, Tran, NamPhuong, Vaissiere, Nathalie, van Son-Palmen, Elisabeth, Xu, Jiajun, Goecker, Erin A., Greninger, Alexander L., Jerome, Keith R., Roychoudhury, Pavitra, Takuva, Simbarashe G., Accini Mendoza, Jose Luis, Achtyes, Eric, Ahsan, Habibul, Alhatemi, Azhar, Allen, Nancy, Arribas, Jose R., Bahrami, Ghazaleh, Bailon, Lucia, Bajwa, Ali, Baker, Jonathan, Baron, Mira, Benet, Susana, Berdaï, Driss, Berger, Patrick, Bertoch, Todd, Bethune, Claire, Bevilacqua, Sybille, Biagioni Santos, Maria Silvia, Binnian, Ian, Bisnauthsing, Karen, Boivin, Jean-Marc, Bollen, Hilde, Bonnet, Sandrine, Borobia, Alberto M., Botelho-Nevers, Elisabeth, Bright, Phil, Britten, Vianne, Brown, Claire, Buadi, Amanda, Buntinx, Erik, Burgess, Lesley, Bush, Larry, Capeding, Maria Rosario, Carr, Quito Osuna, Carrasco Mas, Amparo, Catala, Hélène, Cathie, Katrina, Caudill, T. Shawn, Cereto Castro, Fernando, Chau, Kénora, Chavoustie, Steven, Chowdhury, Marie, Chronos, Nicolas, Cicconi, Paola, Cifuentes, Liliana, Cobo, Sara Maria, Collins, Helen, Colton, Hayley, Cuaño, Carlos Rolando G., D'Onofrio, Valentino, Dargan, Paul, Darton, Thomas, Deane, Peter, Del Pozo, Jose Luis, Derdelinckx, Inge, Desai, Amisha, Dever, Michael, Díaz-Pollán, Beatriz, DiBuono, Mark, Doust, Matthew, Duncan, Christopher, Echave-Sustaeta, Jose Maria, Eder, Frank, Ellis, Kimberly, Elzi, Stanton, Emmett, Stevan, Engelbrecht, Johannes, Evans, Mim, Farah, Theo, Felton, Timothy, Ferreira, João Pedro, Floutier, Catherine, Flume, Patrick, Ford, Stacy, Fragoso, Veronica, Freedman, Andrew, Frentiu, Emilia, Galloway, Christopher, Galtier, Florence, Garcia Diaz, Julia, García García, Irene, Garcia, Alcaide, Gardener, Zoe, Gauteul, Pascale, Geller, Steven, Gibson, Andrew, Gillet, Claudia, Girerd, Nicolas, Girodet, Pierre-Olivier, Gler, Maria Tarcela, Glover, Richard, Go, Herschel Don D., Gokani, Karishma, Gonthier, Damien, Green, Christopher, Greenberg, Richard, Griffin, Carl, Grobbelaar, Coert, Guancia, Adonis, Hakkarainen, Gloria, Harris, James, Hassman, Michael, Heimer, Deirdre, Hellstrom-Louw, Elizabeth, Herades, Yoan, Holroyd, Christopher, Hussen, Nazreen, Isidro, Marie Grace Dawn, Jackson, Yvonne, Jain, Manish, João Filho, Esaú Custódio, Johnson, Daniel, Jones, Ben, Joseph, Natasha, Jumeras, Analyn, Junquera, Patricia, Kellett-Wright, Johanna, Kennedy, Patrick, Kilgore, Paul E., Kim, Kenneth, Kimmel, Murray, Konis, George, Kutner, Mark, Lacombe, Karine, Launay, Odile, Lazarus, Rajeka, Lederman, Samuel, Lefebvre, Gigi, Lennon Collins, Katrina, Leroux-Roels, Isabel, Lim, Kenneth Wilson O., Lins, Muriel, Liu, Edward, Llewelyn, Martin, Mahomed, Akbar, Maia, Bernardo Porto, Marín-Candon, Alícia, Martínez-Gómez, Xavier, Martinot, Jean Benoit, Mazzella, Andrea, McCaughan, Frank, McCormack, Louise, McGettigan, John, Mehra, Purvi, Mejeur, Rhonda, Miller, Vicki, Mills, Anthony, Molto Marhuenda, Jose, Moodley, Prebashan, Mora-Rillo, Marta, Mothe, Beatriz, Mullan, Daniel, Munro, Alasdair, Myers, Paul, Nell, Jeremy, Newman Lobato Souza, Tamara, O'Halloran, Jane A., Ochoa Mazarro, Maria Dolores, Oliver, Abigail, Onate Gutierrez, Jose Millan, Ortega, Jessica, Oshita, Masaru, Otero Romero, Susana, Overcash, Jeffrey Scott, Owens, Daniel, Packham, Alice, Pacurar, Mihaela, Paiva de Sousa, Leonardo, Palfreeman, Adrian, Pallares, Christian José, Patel, Rahul, Patel, Suchet, Pelkey, Leslie, Peluso, Denise, Penciu, Florentina, Pinto, S. Jerry, Pounds, Kevin, Pouzar, Joe, Pragalos, Antoinette, Presti, Rachel, Price, David, Qureshi, Ehsaan, Ramalho Madruga, José Valdez, Ramesh, Mayur, Rankin, Bruce, Razat, Béatrice, Riegel Santos, Breno, Riesenberg, Robert, Riffer, Ernie, Roche, Siobhan, Rose, Katie, Rosellini, Pietro, Rossignol, Patrick, Safirstein, Beth, Salazar, Hernan, Sanchez Vallejo, Gregorio, Santhosh, Smrithi, Seco-Meseguer, Enrique, Seep, Michael, Sherry, Emma, Short, Philip, Soentjens, Patrick, Solis, Joel, Soriano Viladomiu, Alejandro, Sorli, Caroline, Spangenthal, Selwyn, Spence, Niamh, Stephenson, Elaine, Strout, Cynthia, Surowitz, Ronald, Taladua, Kristy Michelle, Tellalian, David, Thalamas, Claire, Thiriphoo, Nang, Thomas, Judith, Thomas, Nicholas, Trout, Guillermo, Urroz, Mikel, Veekmans, Bernard, Veekmans, Laurent, Villalobos, Ralph Elvi M., Warren, Sarah, Webster, Brian, White, Alexander, Williams, Gail, Williams, Hayes, Wilson, Barbara, Winston, Alan, Wiselka, Martin, Zervos, Marcus, Hardt, Karin, Vandebosch, An, Sadoff, Jerald, Le Gars, Mathieu, Truyers, Carla, Lowson, David, Van Dromme, Ilse, Vingerhoets, Johan, Kamphuis, Tobias, Scheper, Gert, Ruiz-Guiñazú, Javier, Faust, Saul N, Spinner, Christoph D, Schuitemaker, Hanneke, Van Hoof, Johan, Douoguih, Macaya, and Struyf, Frank

Published
2022
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7. Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial

Author

Aghdami, Naser, Agüera-Morales, Eduardo, Ali, Rehiana, Allan, David, Arab, Leila, Battaglia, Mario, Berry, Isabelle, Blinkenberg, Morten, Bonetti, Bruno, Brundin, Lou, Capelli, Chiara, Castellan, Lucio, Cellerino, Maria, Cencioni, Maria Teresa, Clanet, Michel, Comi, Giancarlo, Courtman, David, Dazzi, Francesco, Fischer-Nielsen, Anne, Fernandez, Oscar, Fernandez, Victoria, Freedman, Mark S., Furlan, Roberto, Gimona, Mario, Gualandi, Francesca, Guan, Qingdong, Iacobaeus, Ellen, Inglese, Matilde, Introna, Martino, Izquierdo, Guillermo, Karimi, Shahedeh, Laroni, Alice, Le Blanc, Katarina, Loaiza, Sandra, Mallik, Shahrukh, Marley, Stephen, Marrie, Ruth Ann, Marriot, James, Martino, Gianvito, Nabavi, Seyed Massood, Miller, David, Muraro, Paolo A., Nicholas, Richard, Oliveri, Roberto S, Orengo, Giovanni, Palanicawande, Renuka, Pardini, Matteo, Radue, Ernst W, Ramo Tello, Cristina, Rush, Carolina, Schiavetti, Irene, Sellner, Johann, Sensebe, Luc, Soelberg Sorensen, Per, Sormani, Maria Pia, Strunk, Dirk, Szwajcer, David, Thalamas, Claire, Uccelli, Antonio, Wuerfel, Jens Thomas, Battaglia, Mario Alberto, Marriott, James, Muraro, Paolo, Radue, Ernst, Sorensen, Per Soelberg, and Freedman, Mark S

Published
2021
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10. Overt and covert paths for sound in the auditory system of mammals

Author

Auriol, Bernard M., Béard, Jérôme, Broto, Jean-Marc, Descouens, Didier F., Durand, Lise J. S., Garcia, Frederick, Gillieaux, Christian F., Joiner, Elizabeth G., Libes, Bernard, Ruiz, Robert, and Thalamas, Claire

Subjects
Quantitative Biology - Tissues and Organs
Abstract

The consensus, according to which the transmission of sound from the tympanum to the Outer Hair Cells is solely mechanical, is problematic, especially with respect to high pitched sounds. We demonstrate that the collagenous fibers of the tympanum produce electric potentials synchronous to acoustic vibrations and that, contrary to expectations, their amplitude increases as the frequency of the vibration increases. These electrical potentials cannot be reduced to the cochlear microphonic. Moreover, the alteration of collagen as well as that of the gap junctions (electric synapses) necessary for the transmission of the electric potentials to the complex formed by the Deiters Cells and Outer Hair Cells, results in hypoacousis or deafness. The discovery of an electronic pathway, complementary to air and bone conduction has the potential for elucidating certain important as yet unexplained aspects of hearing with respect to cochlear amplification, otoacoustic emissions, and hypoacusis related to the deterioration of collagen or of gap-junctions. Thus, our findings have important implications for both theory and practice., Comment: we submitted a new, more complete version in January 2022

Published
2013

12. Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults

Author

Del Percio, Claudio, Derambure, Philippe, Noce, Giuseppe, Lizio, Roberta, Bartrés-Faz, David, Blin, Olivier, Payoux, Pierre, Deplanque, Dominique, Méligne, Déborah, Chauveau, Nicolas, Bourriez, Jean Louis, Casse-Perrot, Catherine, Lanteaume, Laura, Thalamas, Claire, Dukart, Juergen, Ferri, Raffaele, Pascarelli, Maria Teresa, Richardson, Jill C., Bordet, Regis, and Babiloni, Claudio

Published
2019
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13. A 15-day course of donepezil modulates spectral EEG dynamics related to target auditory stimuli in young, healthy adult volunteers

Author

Leroy, Christopher, Bourriez, Jean-Louis, Dujardin, Kathy, Molaee-Ardekani, Behnam, Babiloni, Claudio, Deplanque, Dominique, Ponchel, Amélie, Hennion, Sophie, Plomhause, Lucie, Devanne, Hervé, Deguil, Julie, Payoux, Pierre, Blin, Olivier, Méligne, Déborah, Micallef, Joëlle, Chauveau, Nicolas, Lanteaume, Laura, Vervueren, Céline, Guimont, François, Thalamas, Claire, Cassé-Perrot, Catherine, Rouby, Franck, Bordet, Régis, and Derambure, Philippe

Published
2019
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14. Naftazone in advanced Parkinson's disease: An acute L-DOPA challenge randomized controlled trial

Author

Corvol, Jean-Christophe, Durif, Franck, Meissner, Wassilios G., Azulay, Jean-Philippe, Haddad, Raphaël, Guimarães-Costa, Raquel, Mariani, Louise-Laure, Cormier-Dequaire, Florence, Thalamas, Claire, Galitzky, Monique, Boraud, Thomas, Debilly, Bérengère, Eusebio, Alexandre, Houot, Marion, Dellapina, Estelle, Chaigneau, Véronique, Salis, Alexandrine, Lacomblez, Lucette, Benel, Laurent, and Rascol, Olivier

Published
2019
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15. ASCOD Phenotyping of Stroke With Anterior Large Vessel Occlusion Treated by Mechanical Thrombectomy

Author

Fontaine, Louis, Sibon, Igor, Raposo, Nicolas, Albucher, Jean-François, Mazighi, Michael, Rousseau, Vanessa, Darcourt, Jean, Thalamas, Claire, Drif, Amel, Sommet, Agnes, Viguier, Alain, Guenego, Adrien, Januel, Anne-Christine, Calvière, Lionel, Menegon, Patrice, Bonneville, Fabrice, Tourdias, Thomas, Albers, Gregory W., Cognard, Christophe, and Olivot, Jean-Marc

Published
2021
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16. Mismatch Profile Influences Outcome After Mechanical Thrombectomy

Author

Olivot, Jean-Marc, Albucher, Jean-François, Guenego, Adrien, Thalamas, Claire, Mlynash, Michael, Rousseau, Vanessa, Drif, Amel, Christensen, Soren, Sommet, Agnes, Viguier, Alain, Darcourt, Jean, Calvière, Lionel, Menegon, Patrice, Raposo, Nicolas, Januel, Anne-Christine, Bonneville, Fabrice, Tourdias, Thomas, Mazighi, Mikael, Sibon, Igor, Albers, Gregory W., and Cognard, Christophe

Published
2020
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17. Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study

Author

Ceccaldi, Mathieu, Guedj, Eric, Felician, Olivier, Didic, Mira, Gueriot, Claude, Koric, Lejla, Kletchkova-Gantchev, Radka, Godefroy, Olivier, Andriuta, Daniela, Devendeville, Agnès, Dupuis, Diane, Binot, Ingrid, Barbay, Mélanie, Meyer, Marc-Etienne, Moullard, Véronique, Magnin, Eloi, Chamard, Ludivine, Haffen, Sophie, Morel, Olivier, Drouet, Clément, Boulahdour, Hatem, Goas, Philippe, Querellou-Lefranc, Solène, de la Sayette, Vincent, Cogez, Julien, Branger, Pierre, Agostini, Denis, Manrique, Alain, Rouaud, Olivier, Bejot, Yannick, Jacquin-Piques, Agnès, Dygai-Cochet, Inna, Berriolo-Riedinger, Alina, Moreaud, Olivier, Sauvee, Mathilde, Crépin, Céline Gallazzani, Pasquier, Florence, Bombois, Stéphanie, Lebouvier, Thibaud, Mackowiak-Cordoliani, Marie-Anne, Deramecourt, Vincent, Rollin-Sillaire, Adeline, Cassagnaud-Thuillet, Pascaline, Chen, Yaohua, Semah, Franck, Petyt, Grégory, Krolak-Salmon, Pierre, Federico, Denis, Danaila, Keren Liora, Guilhermet, Yves, Magnier, Christophe, Makaroff, Zaza, Rouch, Isabelle, Xie, Jing, Roubaud, Caroline, Coste, Marie-Hélène, David, Kenny, Sarciron, Alain, Waissi, Aziza Sediq, Scheiber, Christian, Houzard, Claire, Gabelle-Deloustal, Audrey, Bennys, Karim, Marelli, Cecilia, Touati, Lynda, Mariano-Goulart, Denis, de Verbizier-Lonjon, Delphine, Jonveaux, Thérèse, Benetos, Athanase, Kearney-Schwartz, Anna, Perret-Guillaume, Christine, Verger, Antoine, Vercelletto, Martine, Boutoleau-Bretonniere, Claire, Pouclet-Courtemanche, Hélène, Wagemann, Nathalie, Pallardy, Amandine, Hugon, Jacques, Paquet, Claire, Dumurgier, Julien, Millet, Pascal, Queneau, Mathieu, Dubois, Bruno, Epelbaum, Stéphane, Levy, Marcel, Habert, Marie-Odile, Novella, Jean-Luc, Jaidi, Yacine, Papathanassiou, Dimitri, Morland, David, Belliard, Serge, Salmon, Anne, Lejeune, Florence, Hannequin, Didier, Wallon, David, Martinaud, Olivier, Zarea, Aline, Chastan, Mathieu, Pariente, Jérémie, Thalamas, Claire, Galitzky-Gerber, Monique, Tricoire Ricard, Anne-Marie, Calvas, Fabienne, Rigal, Emilie, Payoux, Pierre, Hitzel, Anne, Delrieu, Julien, Ousset, Pierre-Jean, Lala, Françoise, Sastre-Hengan, Nathalie, Shields, Trevor, Perrotin, Audrey, Gismondi, Rossella, Bullich, Santiago, Jovalekic, Aleksandar, Raffa, Nicola, and Stephens, Andrew

Published
2018
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19. Mismatch Profile Influences Outcome After Mechanical Thrombectomy

Author

Olivot, Jean-Marc, Albucher, Jean-François, Guenego, Adrien, Thalamas, Claire, Mlynash, Michael, Rousseau, Vanessa, Drif, Amel, Christensen, Soren, Sommet, Agnes, Viguier, Alain, Darcourt, Jean, Calvière, Lionel, Menegon, Patrice, Raposo, Nicolas, Januel, Anne-Christine, Bonneville, Fabrice, Tourdias, Thomas, Mazighi, Mikael, Sibon, Igor, Albers, Gregory W., and Cognard, Christophe

Published
2021
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20. Clinical heterogeneity of neuro-inflammatory PET profiles in early Alzheimer’s disease

Author

Gouilly, Dominique, primary, Salabert, Anne-Sophie, additional, Bertrand, Elsa, additional, Goubeaud, Marie, additional, Catala, Hélène, additional, Germain, Johanne, additional, Ainaoui, Nadéra, additional, Rafiq, Marie, additional, Benaiteau, Marie, additional, Carlier, Jasmine, additional, Nogueira, Leonor, additional, Planton, Mélanie, additional, Hitzel, Anne, additional, Méligne, Déborah, additional, Sarton, Benjamine, additional, Silva, Stein, additional, Lemesle, Béatrice, additional, Payoux, Pierre, additional, Thalamas, Claire, additional, Péran, Patrice, additional, and Pariente, Jérémie, additional

Published
2023
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24. Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Hardt, Karin, primary, Vandebosch, An, additional, Sadoff, Jerald, additional, Le Gars, Mathieu, additional, Truyers, Carla, additional, Lowson, David, additional, Van Dromme, Ilse, additional, Vingerhoets, Johan, additional, Kamphuis, Tobias, additional, Scheper, Gert, additional, Ruiz-Guiñazú, Javier, additional, Faust, Saul N, additional, Spinner, Christoph D, additional, Schuitemaker, Hanneke, additional, Van Hoof, Johan, additional, Douoguih, Macaya, additional, Struyf, Frank, additional, Garibaldi, Brian T., additional, Albertson, Timothy E., additional, Sandrock, Christian, additional, Lee, Janet S., additional, Looney, Mark R., additional, Tapson, Victor F., additional, Wiysonge, Charles Shey, additional, Velarde, Luis Humberto Anaya, additional, Backenroth, Daniel, additional, Bhushanan, Jisha, additional, Brandenburg, Börries, additional, Cárdenas, Vicky, additional, Chen, Bohang, additional, Chen, Fei, additional, Chetty, Polan, additional, Chu, Pei-Ling, additional, Cooper, Kimberly, additional, Custers, Jerome, additional, Delanghe, Hilde, additional, Duca, Anna, additional, Henrick, Tracy, additional, Juraszek, Jarek, additional, Nalpas, Catherine, additional, Peeters, Monika, additional, Pinheiro, Jose, additional, Roels, Sanne, additional, Ryser, Martin F., additional, Salas, Jose, additional, Santoro Matias, Samantha, additional, Scheys, Ilse, additional, Shetty, Pallavi, additional, Shukarev, Georgi, additional, Stoddard, Jeffrey, additional, Talloen, Willem, additional, Tran, NamPhuong, additional, Vaissiere, Nathalie, additional, van Son-Palmen, Elisabeth, additional, Xu, Jiajun, additional, Goecker, Erin A., additional, Greninger, Alexander L., additional, Jerome, Keith R., additional, Roychoudhury, Pavitra, additional, Takuva, Simbarashe G., additional, Accini Mendoza, Jose Luis, additional, Achtyes, Eric, additional, Ahsan, Habibul, additional, Alhatemi, Azhar, additional, Allen, Nancy, additional, Arribas, Jose R., additional, Bahrami, Ghazaleh, additional, Bailon, Lucia, additional, Bajwa, Ali, additional, Baker, Jonathan, additional, Baron, Mira, additional, Benet, Susana, additional, Berdaï, Driss, additional, Berger, Patrick, additional, Bertoch, Todd, additional, Bethune, Claire, additional, Bevilacqua, Sybille, additional, Biagioni Santos, Maria Silvia, additional, Binnian, Ian, additional, Bisnauthsing, Karen, additional, Boivin, Jean-Marc, additional, Bollen, Hilde, additional, Bonnet, Sandrine, additional, Borobia, Alberto M., additional, Botelho-Nevers, Elisabeth, additional, Bright, Phil, additional, Britten, Vianne, additional, Brown, Claire, additional, Buadi, Amanda, additional, Buntinx, Erik, additional, Burgess, Lesley, additional, Bush, Larry, additional, Capeding, Maria Rosario, additional, Carr, Quito Osuna, additional, Carrasco Mas, Amparo, additional, Catala, Hélène, additional, Cathie, Katrina, additional, Caudill, T. Shawn, additional, Cereto Castro, Fernando, additional, Chau, Kénora, additional, Chavoustie, Steven, additional, Chowdhury, Marie, additional, Chronos, Nicolas, additional, Cicconi, Paola, additional, Cifuentes, Liliana, additional, Cobo, Sara Maria, additional, Collins, Helen, additional, Colton, Hayley, additional, Cuaño, Carlos Rolando G., additional, D'Onofrio, Valentino, additional, Dargan, Paul, additional, Darton, Thomas, additional, Deane, Peter, additional, Del Pozo, Jose Luis, additional, Derdelinckx, Inge, additional, Desai, Amisha, additional, Dever, Michael, additional, Díaz-Pollán, Beatriz, additional, DiBuono, Mark, additional, Doust, Matthew, additional, Duncan, Christopher, additional, Echave-Sustaeta, Jose Maria, additional, Eder, Frank, additional, Ellis, Kimberly, additional, Elzi, Stanton, additional, Emmett, Stevan, additional, Engelbrecht, Johannes, additional, Evans, Mim, additional, Farah, Theo, additional, Felton, Timothy, additional, Ferreira, João Pedro, additional, Floutier, Catherine, additional, Flume, Patrick, additional, Ford, Stacy, additional, Fragoso, Veronica, additional, Freedman, Andrew, additional, Frentiu, Emilia, additional, Galloway, Christopher, additional, Galtier, Florence, additional, Garcia Diaz, Julia, additional, García García, Irene, additional, Garcia, Alcaide, additional, Gardener, Zoe, additional, Gauteul, Pascale, additional, Geller, Steven, additional, Gibson, Andrew, additional, Gillet, Claudia, additional, Girerd, Nicolas, additional, Girodet, Pierre-Olivier, additional, Gler, Maria Tarcela, additional, Glover, Richard, additional, Go, Herschel Don D., additional, Gokani, Karishma, additional, Gonthier, Damien, additional, Green, Christopher, additional, Greenberg, Richard, additional, Griffin, Carl, additional, Grobbelaar, Coert, additional, Guancia, Adonis, additional, Hakkarainen, Gloria, additional, Harris, James, additional, Hassman, Michael, additional, Heimer, Deirdre, additional, Hellstrom-Louw, Elizabeth, additional, Herades, Yoan, additional, Holroyd, Christopher, additional, Hussen, Nazreen, additional, Isidro, Marie Grace Dawn, additional, Jackson, Yvonne, additional, Jain, Manish, additional, João Filho, Esaú Custódio, additional, Johnson, Daniel, additional, Jones, Ben, additional, Joseph, Natasha, additional, Jumeras, Analyn, additional, Junquera, Patricia, additional, Kellett-Wright, Johanna, additional, Kennedy, Patrick, additional, Kilgore, Paul E., additional, Kim, Kenneth, additional, Kimmel, Murray, additional, Konis, George, additional, Kutner, Mark, additional, Lacombe, Karine, additional, Launay, Odile, additional, Lazarus, Rajeka, additional, Lederman, Samuel, additional, Lefebvre, Gigi, additional, Lennon Collins, Katrina, additional, Leroux-Roels, Isabel, additional, Lim, Kenneth Wilson O., additional, Lins, Muriel, additional, Liu, Edward, additional, Llewelyn, Martin, additional, Mahomed, Akbar, additional, Maia, Bernardo Porto, additional, Marín-Candon, Alícia, additional, Martínez-Gómez, Xavier, additional, Martinot, Jean Benoit, additional, Mazzella, Andrea, additional, McCaughan, Frank, additional, McCormack, Louise, additional, McGettigan, John, additional, Mehra, Purvi, additional, Mejeur, Rhonda, additional, Miller, Vicki, additional, Mills, Anthony, additional, Molto Marhuenda, Jose, additional, Moodley, Prebashan, additional, Mora-Rillo, Marta, additional, Mothe, Beatriz, additional, Mullan, Daniel, additional, Munro, Alasdair, additional, Myers, Paul, additional, Nell, Jeremy, additional, Newman Lobato Souza, Tamara, additional, O'Halloran, Jane A., additional, Ochoa Mazarro, Maria Dolores, additional, Oliver, Abigail, additional, Onate Gutierrez, Jose Millan, additional, Ortega, Jessica, additional, Oshita, Masaru, additional, Otero Romero, Susana, additional, Overcash, Jeffrey Scott, additional, Owens, Daniel, additional, Packham, Alice, additional, Pacurar, Mihaela, additional, Paiva de Sousa, Leonardo, additional, Palfreeman, Adrian, additional, Pallares, Christian José, additional, Patel, Rahul, additional, Patel, Suchet, additional, Pelkey, Leslie, additional, Peluso, Denise, additional, Penciu, Florentina, additional, Pinto, S. Jerry, additional, Pounds, Kevin, additional, Pouzar, Joe, additional, Pragalos, Antoinette, additional, Presti, Rachel, additional, Price, David, additional, Qureshi, Ehsaan, additional, Ramalho Madruga, José Valdez, additional, Ramesh, Mayur, additional, Rankin, Bruce, additional, Razat, Béatrice, additional, Riegel Santos, Breno, additional, Riesenberg, Robert, additional, Riffer, Ernie, additional, Roche, Siobhan, additional, Rose, Katie, additional, Rosellini, Pietro, additional, Rossignol, Patrick, additional, Safirstein, Beth, additional, Salazar, Hernan, additional, Sanchez Vallejo, Gregorio, additional, Santhosh, Smrithi, additional, Seco-Meseguer, Enrique, additional, Seep, Michael, additional, Sherry, Emma, additional, Short, Philip, additional, Soentjens, Patrick, additional, Solis, Joel, additional, Soriano Viladomiu, Alejandro, additional, Sorli, Caroline, additional, Spangenthal, Selwyn, additional, Spence, Niamh, additional, Stephenson, Elaine, additional, Strout, Cynthia, additional, Surowitz, Ronald, additional, Taladua, Kristy Michelle, additional, Tellalian, David, additional, Thalamas, Claire, additional, Thiriphoo, Nang, additional, Thomas, Judith, additional, Thomas, Nicholas, additional, Trout, Guillermo, additional, Urroz, Mikel, additional, Veekmans, Bernard, additional, Veekmans, Laurent, additional, Villalobos, Ralph Elvi M., additional, Warren, Sarah, additional, Webster, Brian, additional, White, Alexander, additional, Williams, Gail, additional, Williams, Hayes, additional, Wilson, Barbara, additional, Winston, Alan, additional, Wiselka, Martin, additional, and Zervos, Marcus, additional

Published
2022
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27. Plasma level of ATPase inhibitory factor 1 (IF1) is associated with type 2 diabetes risk in humans: a prospective cohort study

Author

Silva, Julie Pires, primary, Wargny, Matthieu, additional, Raffin, Jeremy, additional, Croyal, Mikaël, additional, Duparc, Thibaut, additional, Combes, Guillaume, additional, Genoux, Annelise, additional, Perret, Bertrand, additional, Vellas, Bruno, additional, Guyonnet, Sophie, additional, Thalamas, Claire, additional, Langin, Dominique, additional, Moro, Cédric, additional, Viguerie, Nathalie, additional, Rolland, Yves, additional, Barreto, Philipe Souto, additional, Cariou, Bertrand, additional, and Martinez, Laurent O., additional

Published
2022
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29. Essais cliniques institutionnels : quel monitoring ?

Author

Cornu, Catherine, Binquet, Christine, Thalamas, Claire, Vigouroux, Céline, Gaillard, Ségolène, Ginhoux, Tiphanie, Vaz, Bernadette, Jossan, Claire, Félin, Alexandra, Sailly, Annabelle, Gueyffier, François, Journot, Valérie, and Kassaï, Behrouz

Published
2013
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34. A French survey on the lockdown consequences of COVID-19 pandemic in Parkinson's disease. The ERCOPARK study

Author

Fabbri, Margherita, Leung, Clémence, Baille, Guillaume, Béreau, Matthieu, Brefel Courbon, Christine, Castelnovo, Giovanni, Carriere, Nicolas, Damier, Philippe, Defebvre, Luc, Doe de Maindreville, Anne, Fluchere, Frederique, Fuzzatti, Marie, Grabli, David, Maltete, David, Rousseau, Vanessa, Sommet A, Agnès, Thalamas, Claire, Thiriez, Claire, Rascol, Olivier, and Ory-Magne, Fabienne

Published
2021
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35. What predicts poor outcome after successful thrombectomy in early time window?

Author

Olivot, Jean-Marc, primary, Heit, Jeremy J, additional, Mazighi, Mikael, additional, Raposo, Nicolas, additional, Albucher, Jean François, additional, Rousseau, Vanessa, additional, Guenego, Adrien, additional, Thalamas, Claire, additional, Mlynash, Michael, additional, Drif, Amel, additional, Christensen, Soren, additional, Sommet, Agnes, additional, Viguier, Alain, additional, Darcourt, Jean, additional, Januel, Anne-Christine, additional, Calviere, Lionel, additional, Menegon, Patrice, additional, Caparros, François, additional, Bonneville, Fabrice, additional, Tourdias, Thomas, additional, Sibon, Igor, additional, Albers, Gregory W, additional, and Cognard, Christophe, additional

Published
2021
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36. Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial

Author

Uccelli, Antonio, primary, Laroni, Alice, additional, Ali, Rehiana, additional, Battaglia, Mario Alberto, additional, Blinkenberg, Morten, additional, Brundin, Lou, additional, Clanet, Michel, additional, Fernandez, Oscar, additional, Marriott, James, additional, Muraro, Paolo, additional, Nabavi, Seyed Massood, additional, Oliveri, Roberto S, additional, Radue, Ernst, additional, Ramo Tello, Cristina, additional, Schiavetti, Irene, additional, Sellner, Johann, additional, Sorensen, Per Soelberg, additional, Sormani, Maria Pia, additional, Wuerfel, Jens Thomas, additional, Freedman, Mark S, additional, Aghdami, Naser, additional, Agüera-Morales, Eduardo, additional, Allan, David, additional, Arab, Leila, additional, Battaglia, Mario, additional, Berry, Isabelle, additional, Bonetti, Bruno, additional, Capelli, Chiara, additional, Castellan, Lucio, additional, Cellerino, Maria, additional, Cencioni, Maria Teresa, additional, Comi, Giancarlo, additional, Courtman, David, additional, Dazzi, Francesco, additional, Fischer-Nielsen, Anne, additional, Fernandez, Victoria, additional, Freedman, Mark S., additional, Furlan, Roberto, additional, Gimona, Mario, additional, Gualandi, Francesca, additional, Guan, Qingdong, additional, Iacobaeus, Ellen, additional, Inglese, Matilde, additional, Introna, Martino, additional, Izquierdo, Guillermo, additional, Karimi, Shahedeh, additional, Le Blanc, Katarina, additional, Loaiza, Sandra, additional, Mallik, Shahrukh, additional, Marley, Stephen, additional, Marrie, Ruth Ann, additional, Marriot, James, additional, Martino, Gianvito, additional, Miller, David, additional, Muraro, Paolo A., additional, Nicholas, Richard, additional, Orengo, Giovanni, additional, Palanicawande, Renuka, additional, Pardini, Matteo, additional, Radue, Ernst W, additional, Rush, Carolina, additional, Sensebe, Luc, additional, Soelberg Sorensen, Per, additional, Strunk, Dirk, additional, Szwajcer, David, additional, Thalamas, Claire, additional, and Uccelli, Antonio, additional

Published
2021
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37. Metabolic and cardiovascular adaptations to an 8-wk lifestyle weight loss intervention in younger and older obese men

Author

Vion, Julie, primary, Sramkova, Veronika, additional, Montastier, Emilie, additional, Marquès, Marie-Adeline, additional, Caspar-Bauguil, Sylvie, additional, Duparc, Thibaut, additional, Martinez, Laurent O., additional, Bourlier, Virginie, additional, Harant, Isabelle, additional, Larrouy, Dominique, additional, Moussaoui, Nabila, additional, Bonnel, Sophie, additional, Vindis, Cécile, additional, Dray, Cédric, additional, Valet, Philippe, additional, Saulnier-Blache, Jean-Sébastien, additional, Schanstra, Joost P., additional, Thalamas, Claire, additional, Viguerie, Nathalie, additional, Moro, Cedric, additional, and Langin, Dominique, additional

Published
2021
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39. Exploratory Clinical Trials: Implementation Modes & Guidelines, Scope and Regulatory Framework

Author

Abiteboul, Michel, Bégaud, Bernard, Behier, Jehan-Michel, Belorgey, Chantal, Chauvin, Bénédicte, Cournot, Antoine, Defrance, Rémy, Demarez, Jean-Paul, Devilliers, Élisabeth, Diebolt, Vincent, Diquet, Bertrand, Donazzolo, Yves, Echemann, Muriel, Francillon, Alain, Funck-Brentano, Christian, Genissel, Patrick, Houedé, Nadine, Husson, Jean-Marc, Lefevre, Philippe, Macquin-Mavier, Isabelle, Marchenay, Brigitte, Marey, Christine, Negres-Pages, Laurence, Pickering, Gisèle, Pitel, Séverine, Plattner, Valérie, Roy, Christine, Sibille, Michel, Simon, Nicolas, Thalamas, Claire, Tremblay, Dominique, and Waegemans, Tony

Published
2009
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40. Essais cliniques exploratoires : quelles modalités de mise en œuvre, recommandations de mise en œuvre, champ d’application, cadre réglementaire ?

Author

Abiteboul, Michel, Bégaud, Bernard, Behier, Jehan-Michel, Belorgey, Chantal, Chauvin, Bénédicte, Cournot, Antoine, Defrance, Rémy, Demarez, Jean-Paul, Devilliers, Élisabeth, Diebolt, Vincent, Diquet, Bertrand, Donazzolo, Yves, Echemann, Muriel, Francillon, Alain, Funck-Brentano, Christian, Genissel, Patrick, Houedé, Nadine, Husson, Jean-Marc, Lefevre, Philippe, Macquin-Mavier, Isabelle, Marchenay, Brigitte, Marey, Christine, Negres-Pages, Laurence, Pickering, Gisèle, Pitel, Séverine, Plattner, Valérie, Roy, Christine, Sibille, Michel, Simon, Nicolas, Thalamas, Claire, Tremblay, Dominique, and Waegemans, Tony

Published
2009
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42. What predicts poor outcome after successful thrombectomy in early time window?

Author

Olivot, Jean-Marc, Heit, Jeremy J., Mazighi, Mikael, Raposo, Nicolas, Albucher, Jean François, Rousseau, Vanessa, Guenego, Adrien, Thalamas, Claire, Mlynash, Michael, Drif, Amel, Christensen, Soren, Sommet, Agnes, Viguier, Alain, Darcourt, Jean, Januel, Anne-Christine, Calviere, Lionel, Menegon, Patrice, Caparros, François, Bonneville, Fabrice, and Tourdias, Thomas

Subjects
SURGICAL complication risk factors, MORTALITY risk factors, HEART radiography, CONFIDENCE intervals, CEREBRAL revascularization, MULTIPLE regression analysis, NIH Stroke Scale, RISK assessment, DIAGNOSTIC imaging, THROMBECTOMY, DESCRIPTIVE statistics, ENDOVASCULAR surgery, ODDS ratio
Abstract

Background Half of the patients with large vessel occlusion (LVO)-related acute ischemic stroke (AIS) who undergo endovascular reperfusion are dead or dependent at 3 months. We hypothesize that in addition to established prognostic factors, baseline imaging profile predicts outcome among reperfusers. Methods Consecutive patients receiving endovascular treatment (EVT) within 6 hours after onset with Thrombolysis In Cerebral Infarction (TICI) 2b, 2c and 3 revascularization were included. Poor outcome was defined by a modified Rankin scale (mRS) 3-6 at 90 days. No mismatch (NoMM) profile was defined as a mismatch (MM) ratio ≤1.2 and/or a volume <10 mL on pretreatment imaging. Results 187 patients were included, and 81 (43%) had a poor outcome. Median delay from stroke onset to the end of EVT was 259 min (IQR 209-340). After multivariable logistic regression analysis, older age (OR 1.26, 95% CI 1.06 to 1.5; p=0.01), higher National Institutes of Health Stroke Scale (NIHSS) (OR 1.15, 95% CI 1.06 to 1.25; p<0.0001), internal carotid artery (ICA) occlusion (OR 3.02, 95% CI 1.2 to 8.0; p=0.021), and NoMM (OR 4.87, 95% CI 1.09 to 22.8; p=0.004) were associated with poor outcome. In addition, post-EVT hemorrhage (OR 3.64, 95% CI 1.5 to 9.1; p=0.04) was also associated with poor outcome. Conclusions The absence of a penumbra defined by a NoMM profile on baseline imaging appears to be an independent predictor of poor outcome after reperfusion. Strategies aiming to preserve the penumbra may be encouraged to improve these patients' outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Natriuretic peptides enhance the oxidative capacity of human skeletal muscle

Author

Engeli, Stefan, Birkenfeld, Andreas L., Badin, Pierre-Marie, Bourlier, Virginie, Louche, Katie, Viguerie, Nathalie, Thalamas, Claire, Montastier, Emilie, Larrouy, Dominique, Harant, Isabelle, Glisezinski, Isabelle de, Lieske, Stefanie, Reinke, Julia, Beckmann, Bibiana, Langin, Dominique, Jordan, Jens, and Moro, Cedric

Subjects
Exercise -- Physiological aspects, Natriuretic peptides -- Physiological aspects, Oxidative stress -- Physiological aspects, Muscles -- Physiological aspects, Health care industry
Abstract

Cardiac natriuretic peptides (NP) are major activators of human fat cell lipolysis and have recently been shown to control brown fat thermogenesis. Here, we investigated the physiological role of NP on the oxidative metabolism of human skeletal muscle. NP receptor type A (NPRA) gene expression was positively correlated to mRNA levels of PPAR γ coactivator-1 α (PGC1A) and several oxidative phosphorylation (OXPHOS) genes in human skeletal muscle. Further, the expression of NPRA, PGC1A, and OXPHOS genes was coordinately upregulated in response to aerobic exercise training in human skeletal muscle. In human myotubes, NP induced PGC-1 α and mitochondrial OXPHOS gene expression in a cyclic GMP-dependent manner. NP treatment increased OXPHOS protein expression, fat oxidation, and maximal respiration independent of substantial changes in mitochondrial proliferation and mass. Treatment of myotubes with NP recapitulated the effect of exercise training on muscle fat oxidative capacity in vivo. Collectively, these data show that activation of NP signaling in human skeletal muscle enhances mitochondrial oxidative metabolism and fat oxidation. We propose that NP could contribute to exercise training-induced improvement in skeletal muscle fat oxidative capacity in humans., Introduction The cardiac hormones, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), play a major role in the regulation of fluid homeostasis and cardiac physiology (1). Natriuretic peptide-mediated (NP-mediated) [...]

Published
2012
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46. Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men

Author

Moro, Cedric, Pillard, Fabien, de Glisezinski, Isabelle, Klimcakova, Eva, Crampes, Francois, Thalamas, Claire, Harant, Isabelle, Marques, Marie-Adeline, Lafontan, Max, and Berlan, Michel

Subjects
Adipose tissues -- Evaluation, Lipid metabolism -- Evaluation, Obesity -- Physiological aspects, Biological sciences
Abstract

Involvement of sympathetic nervous system and natriuretic peptides in the control of exercise-induced lipid mobilization was compared in overweight and lean men. Lipid mobilization was determined using local microdialysis during exercise. Subjects performed 35-min exercise bouts at 60% of their maximal oxygen consumption under placebo or after oral tertatolol [a [beta]-adrenergic receptor (AR) antagonist]. Under placebo, exercise increased dialysate glycerol concentration (DGC) in both groups. Phentolamine ([alpha]-AR antagonist) potentiated exercise-induced lipolysis in overweight but not in lean subjects; the [[alpha].sub.2]-antilipolytic effect was only functional in overweight men. After tertatolol administration, the DGC increased similarly during exercise no matter which was used probe in both groups. Compared with the control probe under placebo, lipolysis was reduced in lean but not in overweight men treated with the [beta]-AR blocker. Tertatolol reduced plasma nonesterified fatty acids and insulin concentration in both groups at rest. Under placebo or tertatolol, the exercise-induced changes in plasma nonesterified fatty acids, glycerol, and insulin concentrations were similar in both groups. Exercise promoted a higher increase in catecholamine and ANP plasma levels after tertatolol administration. In conclusion, the major finding of our study is that in overweight men, in addition to an increased [[alpha].sub.2]-antilipolytic effect, the lipid mobilization in subcutaneous adipose tissue that persists during exercise under [beta]-blockade is not dependent on catecholamine action. On the basis of correlation findings, it seems to be related to a concomitant exercise-induced rise in plasma ANP when exercise is performed under tertatolol intake and a decrease in plasma insulin. microdialysis; tertatolol; atrial natriuretic peptide; insulin

Published
2008

47. Thrombocytopenia is independently associated with poor outcome in patients hospitalized for COVID‐19

Author

Maquet, Julien, Lafaurie, Margaux, Sommet, Agnès, Moulis, Guillaume, Alvarez, Muriel, Amar, Jacques, Attal, Michel, Balardy, Laurent, Balen, Frédéric, Beyne‐Rauzy, Odile, Bouali, Ourdia, Bounes, Fanny, Bureau, Christophe, Buscail, Louis, Calviere, Lionel, Charpentier, Sandrine, Chollet, François, Claudet, Isabelle, Constantin, Arnaud, Debard, Alexa, Delavigne, Karen, Delobel, Pierre, Delrieu, Julien, Didier, Alain, Faruch, Marie, Fourcade, Olivier, Georges, Bernard, Grunenwald, Etienne, Guyonnet, Sophie, Hanaire, Hélène, Hein, Christophe, Kamar, Nassim, Lairez, Olivier, Mansat, Pierre, Martin‐Blondel, Guillaume, Minville, Vincent, Pariente, Jérémie, Paul, Carle, Payoux, Pierre, Pugnet, Grégory, Piel‐Julian, Marie‐Léa, Recher, Christian, Rolland, Yves, Ruyssen‐Witrand, Adeline, Sabatier, Jean, Sailler, Laurent, Salles, Jean‐Pierre, Sans, Nicolas, Secher, Marion, Sevely, Annick, Silva, Stein, Thalamas, Claire, and Toulza, Olivier

Subjects
Male, medicine.medical_specialty, Letter, Coronavirus disease 2019 (COVID-19), Pneumonia, Viral, Population, thrombocytopenia, COVID‐2019, intensive care unit, SARS‐CoV‐2, Disease-Free Survival, law.invention, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, law, Internal medicine, medicine, Humans, Platelet, Letters, Prospective Studies, Platelet activation, education, Prospective cohort study, Pandemics, Survival rate, Aged, education.field_of_study, Hematology, SARS-CoV-2, business.industry, COVID-19, Middle Aged, mortality, Intensive care unit, Hospitalization, Survival Rate, 030220 oncology & carcinogenesis, Female, Coronavirus Infections, business, 030215 immunology
Abstract

Thrombocytopenia (defined by platelet count

Published
2020

48. Reducing Attentional Bias in Individuals With Alcohol Use Disorders With a Tablet Application: A Randomized Controlled Trial Pilot Study

Author

Pereira, Bruno, Benchetrit, Eve, Socha, Julie, Pineau, Fanny, Elbaz, Alexis, Artaud, Fanny, Mangone, Graziella, You, Hana, Cormier, Florence, Galitstky, Monique, Pomies, Elsa, Derkinderen, Pascal, Weintraub, Daniel, Corvol, Jean Christophe, Chereau-Boudet, Isabelle, Fantini, Maria Livia, Marques, Ana, Derost, Philippe, Boirie, Yves, Girard, Romuald, Obeso, Ignacio, Thobois, Stéphane, Park, Seongmin, Vidal, Tiphaine, Favre, Emilie, Ulla, Miguel, Broussolle, Emmanuel, Krack, Paul, Dreher, Jean-Claude, Corvol, Jean-Christophe, Durif, Franck, Meissner, Wassilios, Azulay, Jean-Philippe, Haddad, Raphaël, Guimarães-Costa, Raquel, Mariani, Louise-Laure, Cormier-Dequaire, Florence, Thalamas, Claire, Galitzky, Monique, Boraud, Thomas, Debilly, Bérengère, Eusebio, Alexandre, Houot, Marion, Dellapina, Estelle, Chaigneau, Véronique, Salis, Alexandrine, Lacomblez, Lucette, Benel, Laurent, Rascol, Olivier, Flaudias, Valentin, Zerhouni, Oulmann, Chakroun-Baggioni, Nadia, Pires, Sylvie, Schmitt, Audrey, De Chazeron, Ingrid, Llorca, Pierre Michel, Brousse, Georges, Service de Psychiatrie de l'Adulte B [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire Parisien de Psychologie Sociale (LAPPS), Université Paris Nanterre (UPN)-Université Paris 8 Vincennes-Saint-Denis (UP8), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), service de Biostatistiques, DRCI, Centre Hospitalier Universitaire de Clermont-Ferrand, Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique (CNRS), Epidemiology, Departments of Health Sciences Research, Mayo Clinic College of Medicine, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Neuropathies du système nerveux entérique et pathologies digestives, implication des cellules gliales entériques, Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Neurology, University of Pennsylvania [Philadelphia], Centres d'addictologies - Région Centre, CHU Clermont-Ferrand, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Service de neurologie, Hôpital Gabriel Montpied, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie, Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service de Neurologie [CHU Clermont-Ferrand], Hospices Civils de Lyon (HCL), Neurosciences précliniques, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de Myologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de neurologie [Le Kremlin Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bicêtre, CIC - Biotherapie - Toulouse, Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Toulouse, Laboratoire Mouvement Adaptation Cognition (MAC), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Imagerie cérébrale et handicaps neurologiques, Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social (LIP-PC2S ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Grenoble Alpes (UGA), Laboratoire de Psychologie Sociale et Cognitive - Clermont Auvergne (LAPSCO), Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), and Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)

Subjects
Adult, Male, Cognitive bias modification, Ecological validity, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Mental processes, education, Craving, Pilot Projects, Alcohol use disorder, Attentional bias, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Memory, medicine, Humans, ComputingMilieux_MISCELLANEOUS, Tablet dosage form, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Cognitive Behavioral Therapy, Ethanol, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Play behavior, Cognition, General Medicine, Middle Aged, medicine.disease, Cognitive bias, 030227 psychiatry, Alcoholism, Inhibition, Psychological, Treatment Outcome, Therapy, Computer-Assisted, [SCCO.PSYC]Cognitive science/Psychology, Female, medicine.symptom, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Clinical psychology
Abstract

Aims Cognitive bias modification (CBM) training has been considered a promising and effective intervention tool for reducing cognitive biases toward alcohol. However, the link between the cognitive process and actual behavior remains statistically insignificant because computerized tasks do not have sufficient ecological validity and suffer from high dropout rates. The recent development of ‘serious games’ has shown encouraging results in maintaining adherence to health-related interventions. We aim to evaluate a CBM program using a gamified attentional bias (AB) training procedure on a touchpad for individuals with alcohol use disorders. Methods Forty-one patients were included in this study, 33 of whom displayed an AB and were randomly assigned into the ‘CBM group’ (N = 18, 16.7% women) or ‘Memory group’—which involved playing a memory game—(N = 15, no woman). Eight other participants (12.5% women) with no AB comprised the ‘Without AB group’. Efficacy was assessed for AB, craving, and inhibition and attentional capacities before and after the program. Results We observed that the reduction of AB was higher for the ‘CBM group’ (Mbefore = 153.61, SD = 172.21; Mafter = 18.00, SD = 77.71; t (17) = 4.21, P = 0.001) than for the ‘Memory group’ (Mbefore = 73.20, SD = 66.65; Mafter =42.47, SD = 113.77; ts Conclusions This study demonstrated an increased reduction of AB for patients included in the CBM program on a touchpad than for patients playing only a memory game.

Published
2020

49. Atrial natriuretic peptide contribution to lipid mobilization and utilization during head-down bed rest in humans

Author

Moro, Cedric, Pillard, Fabien, de Glisezinski, Isabelle, Crampes, Francois, Thalamas, Claire, Harant, Isabelle, Marques, Marie-Adeline, Lafontan, Max, and Berlan, Michel

Subjects
Natriuretic peptides -- Influence, Lipolysis -- Evaluation, Lipid peroxidation -- Evaluation, Bed rest -- Physiological aspects, Biological sciences
Abstract

Head-down bed rest (HDBR) increases plasma levels of atrial natriuretic peptide (ANP) and decreases norepinephrine levels. We previously demonstrated that ANP promotes lipid mobilization and utilization, an effect independent of sympathetic nervous system activation, when infused into lean healthy men at pharmacological doses. The purpose of the present study was to demonstrate that a physiological increase in ANP contributes to lipid mobilization and oxidation in healthy young men. Eight men were positioned for 4 h in a sitting (control) or in a HDBR position. Indexes of lipid mobilization and hormonal changes were measured in plasma. Extracellular glycerol, an index of lipolysis, was determined in subcutaneous adipose tissue (SCAT) with a microdialysis technique. A twofold increase in plasma ANP concentration was observed after 60 min of HDBR, and a plateau was maintained thereafter. Plasma norepinephrine decreased by 30-40% during HDBR, while plasma insulin and glucose levels did not change. The level of plasma nonesterified fatty acids was higher during HDBR. SCAT lipolysis, as reflected by interstitial glycerol, as well as interstitial cGMP, the second messenger of the ANP pathway, increased during HDBR. This was associated with an increase in blood flow observed throughout HDBR. Significant changes in respiratory exchange ratio and percent use of lipid and carbohydrate were seen only after 3 h of HDBR. Thus the proportion of lipid oxidized increased by 40% after 3 h of HDBR. The rise in plasma ANP during HDBR was associated with increased lipolysis in SCAT and whole body lipid oxidation. In this physiological setting, independent of increasing catecholamines, our study suggests that ANP contributes to lipid mobilization and oxidation in healthy young men. lipolysis; lipid oxidation

Published
2007

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