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602 results on '"Thankappan, Krishnakumar"'

2. Improving accuracy in nodal staging of oral cancer: Proposal of a new system

Author

Subramaniam, Narayana, Heller, Gillian, Clark, Jonathan Robert, Gupta, Ruta, Goldstein, David, de Almeida, John R., Hosni, Ali, Balasubramanian, Deepak, Thankappan, Krishnakumar, Iyer, Subramania, Batstone, Martin, Iyer, N. Gopal, Smee, Robert I., Chandrasekhar, Naveen Hedne, Pillai, Vijay, Shetty, Vivek, Rangappa, Vidyabhushan, Veness, Michael, and Low, Tsu-Hui (Hubert)

Published
2024
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5. Oncological outcomes of compartmental surgery and wide local excision in oral tongue and floor of the mouth cancer

Author

Missale, Francesco, Marchi, Filippo, Iandelli, Andrea, Subramaniam, Narayana, Dokhe, Yogesh, Sampieri, Claudio, Mattavelli, Davide, Bresciani, Lorenzo, Carobbio, Andrea Luigi Camillo, Grammatica, Alberto, Thankappan, Krishnakumar, Iyer, Subramania, Fontanella, Walter, Giannini, Lorenzo, Peretti, Giorgio, Parrinello, Giampiero, Balasubramanian, Deepak, and Piazza, Cesare

Published
2022
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7. Epidemiology

Author

Dokhe, Yogesh, Vidhydharan, Sivakumar, Thankappan, Krishnakumar, Iyer, Subramania, Bahadur, Sudhir, editor, and Iyer, Subramania, editor

Published
2021
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11. Lip Reconstruction

Author

Jani, Khyati, Balasubramanian, Deepak, Thankappan, Krishnakumar, Iyer, Subramania, Bahadur, Sudhir, editor, and Iyer, Subramania, editor

Published
2021
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20. Geographical heterogeneity in the American Joint committee on Cancer oral cancer staging and prognostic implications

Author

Subramaniam, Narayana, Clark, Jonathan Robert, Goldstein, David, de Almeida, John, Abdalaty, Ali Hosni Ali, Balasubramanian, Deepak, Thankappan, Krishnakumar, Iyer, Subramania, Batstone, Martin, Iyer, N. Gopal, Smee, Robert I, Chandrasekhar, Naveen Hedne, Pillai, Vijay, Shetty, Vivek, Rangappa, Vidyabhushan, Veness, Michael, and Low, Tsu-Hui Hubert

Published
2021
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28. Cranial Nerve Palsy and Dysphagia

Author

Limbachiya, Shashikant Vishnubhai, Thankappan, Krishnakumar, Menon, Jayakumar R., Thankappan, Krishnakumar, editor, Iyer, Subramania, editor, and Menon, Jayakumar R, editor

Published
2018
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32. Compensatory Therapy

Author

Varghese, Anju Elsa, Thankappan, Krishnakumar, Thankappan, Krishnakumar, editor, Iyer, Subramania, editor, and Menon, Jayakumar R, editor

Published
2018
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33. Rehabilitative Therapy

Author

Mayadevi, Mydhili, Thankappan, Krishnakumar, Thankappan, Krishnakumar, editor, Iyer, Subramania, editor, and Menon, Jayakumar R, editor

Published
2018
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38. Two by Two Factorial Design using Metformin and Curcumin for Second Primary Head and Neck Cancer Prevention Trial.

Author

Kekatpure, Vikram, Subramaniam, Narayana, Sunny, Sumsum, Nambiar, Sruthi, Sarah, Tinku, Vasudevan, Vaishnav, Rao, Anusha, Murali, Anupama, Kolur, Trupti, Krishnamurthy, Arvind, Kantharia, Rajesh, Nair, Sudhir V., Thankappan, Krishnakumar, M. N., Baruah, Kumar, Rajeev, Balasubramanian, Satheesan, Toprani, Rajendra, Agrawala, Sunil, Battoo, Azar Jan, and Bakshi, Jaimanti

Published
2024
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39. Diagnostic efficacy of dynamic contrast-enhanced magnetic resonance perfusion imaging in detecting local tumor recurrence in patients with head and neck malignancies after definitive treatment.

Author

Lathika, Anand G., Jayasankaran, Sandya C., Chelakkot, Prameela G., Thankappan, Krishnakumar, and Moorthy, Srikanth

Subjects
CONTRAST-enhanced magnetic resonance imaging, NECK tumors, HEAD tumors, PERFUSION imaging, MAGNETIC resonance imaging, HEAD & neck cancer
Abstract

Background and Aim: Accurate interpretation of post-treatment imaging in head and neck malignancies poses a challenge due to treatment sequelae. Magnetic resonance (MR) perfusion helps in this scenario by evaluating the hemodynamic characteristics of lesions. This study aimed to elucidate the diagnostic efficacy of dynamic contrast-enhanced (DCE)-MR perfusion imaging in detecting recurrence in patients after they underwent definitive treatment for head and neck tumors. Materials and Methods: Thirty patients who had received definitive curative-intent treatment for histopathology-proven malignant head and neck tumors and in whom recurrent tumor was detected on precontrast MR imaging (MRI) were accrued in the study. Patients underwent DCE-MR perfusion imaging. Time to peak (TTP), relative maximum enhancement (RME), and relative washout (RWO) ratio were calculated by using time-intensity curve (TIC). The diagnostic accuracy was compared with histopathology. Results: A cut-off value of ≥125.3 for RME showed a sensitivity of 76.2% and specificity of 66.7% for differentiating post-radiation changes and recurrence. The optimal cut-off for RWO ratio was ≥-6.24 with a sensitivity of 76.2% and specificity of 55.6%. The optimal cut-off of TTP was ≤45.8 s with a sensitivity of 61.9% and specificity of 77.8%. Diagnostic accuracies of RME, RWO, and TTP were 73.3%, 70%, and 66.7%, respectively. Conclusions: DCE-MRI had significant diagnostic accuracy in detecting and differentiating recurrences. TIC analysis of high-temporal resolution DCE-MRI can provide information regarding microcirculation of tumors, and hence can be considered as an imaging modality of choice for assessment of early local tumor recurrence in head and neck tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Contrasting clinical outcomes and socio‐economic impact of young versus elderly‐onset oral squamous cell carcinoma, a novel health economic analysis.

Author

Singh, Manraj, Thankappan, Krishnakumar, Balasubramanian, Deepak, Pillai, Vijay, Shetty, Vivek, Rangappa, Vidyabhushan, Chandrasekhar, Naveen Hedne, Kekatpure, Vikram, Kuriakose, Moni Abraham, Krishnamurthy, Arvind, Mitra, Arun, Pattatheyil, Arun, Jain, Prateek, Iyer, Subramania, Iyer, N. Gopalakrishna, and Subramaniam, Narayana

Subjects
*SQUAMOUS cell carcinoma, *EARLY death, *TREATMENT effectiveness, *ECONOMIC impact, *OLDER patients
Abstract

Objectives: The incidence of young‐onset oral squamous cell carcinoma (OSCC) is growing, even among non‐smokers/drinkers. The effects of adverse histopathological features on long‐term oncologic outcomes between the young and old are controversial and confounded by significant heterogeneity. Few studies have evaluated the socio‐economic impact of premature mortality from OSCC. Our study seeks to quantify these differences and their economic impact on society. Materials and Methods: Four hundred and seventy‐eight young (<45 years) and 1660 old patients (≥45 years) with OSCC were studied. Logistic regression determined predictors of recurrence and death. Survival analysis was calculated via the Kaplan–Meier method. A separate health economic analysis was conducted for India and Singapore. Years of Potential Productive Life Lost (YPPLL) were estimated with the Human Capital Approach, and premature mortality cost was derived using population‐level data. Results: Adverse histopathological features were seen more frequently in young OSCC: PNI (42.9% vs. 35%, p = 0.002), LVI (22.4% vs. 17.3%, p = 0.013) and ENE (36% vs. 24.5%, p < 0.001). Although 5‐year OS/DSS were similar, the young cohort had received more intensive adjuvant therapy (CCRT 26.9% vs. 16.6%, p < 0.001). Among Singaporean males, the premature mortality cost per death was US $396,528, and per YPPLL was US $45,486. This was US $397,402 and US $38,458 for females. Among Indian males, the premature mortality cost per death was US $30,641, and per YPPLL was US $595. This was US $ 21,038 and US $305 for females. Conclusion: Young‐onset OSCC is an aggressive disease, mitigated by the ability to receive intensive adjuvant treatment. From our loss of productivity analysis, the socio‐economic costs from premature mortality are substantial. Early cancer screening and educational outreach campaigns should be tailored to this cohort. Alongside, more funding should be diverted to genetic research, developing novel biomarkers and improving the efficacy of adjuvant treatment in OSCC. [ABSTRACT FROM AUTHOR]

Published
2024
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