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1. Promoting Student Success in Early College Credit Courses. Overview Brief #28: Postsecondary Transitions

Author: EdResearch for Action, Annenberg Institute for School Reform at Brown University, University of North Carolina at Chapel Hill, George Washington University (GW), Results for America, Dylan Conger, Steven W. Hemelt, and María Luisa Vásquez
Abstract: The EdResearch for Action "Overview Series" summarizes the research on key topics to provide K-12 education decision makers and advocates with an evidence base to ground discussions about how to best serve students. Authors -- leading experts from across the field of education research -- are charged with highlighting key findings from research that provide concrete, strategic insight on persistent challenges sourced from district and state leaders. This brief asks how districts and states can promote equitable success in academic early college credit courses and covers research on early college credit courses that focus on academic and general content as opposed to career and technical education (CTE).
Published: 2024

2. Expanding Apprenticeship to New Sectors and Populations: The Experiences and Outcomes of Apprentices in the American Apprenticeship Initiative

Author: Abt Associates, Inc., George Washington University (GW), Employment and Training Administration (ETA) (DOL), Walton, Douglas, Gardiner, Karen N., and Barnow, Burt
Abstract: The U.S. Department of Labor's (DOL) American Apprenticeship Initiative (AAI) supported 46 grantees across the country to expand registered apprenticeship into new sectors, such as healthcare, and to populations historically underrepresented in apprenticeships. DOL commissioned an evaluation of the AAI grants to build evidence about the effectiveness of registered apprenticeship for apprentices and employers. This report presents findings from the outcomes study of that evaluation. It examines the characteristics, reasons for enrollment, program experiences, and post-program outcomes of AAI apprentices and pre-apprentices. The data sources include an AAI Apprentice Survey administered to a sample of approximately 2,600 registered apprentices, program records from grantees, and administrative earnings data from the National Directory of New Hires.
Published: 2022

3. Structural Supports to Promote Teacher Well-Being. Brief No. 19

Author: EdResearch for Recovery Project, Annenberg Institute for School Reform at Brown University, Results for America, George Washington University (GW), Center for Health and Health Care in Schools, Santoro, Doris A., and Price, Olga Acosta
Abstract: This brief is one in a series aimed at providing K-12 education decision makers and advocates with an evidence base to ground discussions about how to best serve students during and following the novel coronavirus pandemic. It addresses one central question: What does the research say about structural supports that enable teacher well-being? In order to answer this question, the brief breaks down the issue into three points: (1) Burnout and demoralization are meaningfully different forms of work dissatisfaction that each affect teachers' ability to do their jobs and influence decisions to remain in the profession; (2) System and school conditions contribute to or buffer against demoralization and burnout in ways that directly affect the lives of both teachers and students; and (3) Evidence is growing that the pandemic has increased demoralization and burnout among many teachers. Based on these points, the brief provides six strategies to consider and two strategies to avoid. [This brief was co-prepared by Bowdoin College.]
Published: 2021

4. Trade Adjustment Assistance Community College and Career Training Grant Program: Round 4 Early Outcomes Study Report. Technical Appendices

Author: Abt Associates, Inc., Urban Institute, George Washington University (GW), Walton, Douglas, Judkins, David, Kolenikov, Stas, Schalk, Marci, and Smith, Adrienne
Abstract: This document includes seven technical appendices that accompany the main report, "Trade Adjustment Assistance Community College and Career Training Grant Program: Round 4 Early Outcomes Study Report." The appendices include: (1) Baseline Data; (2) Follow-up Survey Data; (3) Unemployment Insurance Wage Data; (4) Service Impacts; (5) Methodology for Estimating Outcomes by Program; (6) Implementation Data Collection; and (7) Expanded Results. [This document was produced in partnership with Capital Research Corporation. For the main report, see ED610190.]
Published: 2020

5. Trade Adjustment Assistance Community College and Career Training Grant Program: Round 4 Early Outcomes Study Report

Author: Abt Associates, Inc., Urban Institute, George Washington University (GW), Judkins, David, Gardiner, Karen, Smith, Adrienne, and Walton, Douglas
Abstract: The Trade Adjustment Assistance Community College and Career Training (TAACCCT) program provided grants to community colleges and other eligible institutions of higher education to expand and improve their ability to deliver education and career training programs. Grant-funded colleges served workers who were eligible for training under the Trade Adjustment Assistance for Workers (TAA) program as well as other adults in need of training for in-demand occupations. In doing so, the grant program supported the U.S. Department of Labor's (DOL) goal of training workers with the skills to succeed in fast-growing, high-wage occupations. Between 2011 and 2014, the grant program awarded $1.9 billion across four rounds of grants to more than 1,000 colleges nationwide. The fourth and final round of grants (71 grantees, 263 colleges) ended in 2018. In order to build evidence on grant-funded programs and strategies, DOL funded a national evaluation of each grant round to collect and assess qualitative and quantitative data across all participating colleges. The Round 4 evaluation included an outcomes study, the focus of this report. This report describes the training, employment, earnings, and self-sufficiency outcomes of nearly 2,800 participants who enrolled in 34 programs at nine Round 4 grantees. The overarching research questions are: (1) What were the characteristics of study participants?; (2) In which features of training programs and services did study participants engage?; (3) What education outcomes did study participants in short-term training programs achieve?; and (4) Did participants obtain employment? If so, was it in an occupation related to their training? What were their earnings? What were the characteristics of their jobs? The analyses presented in this report use data collected from study participants at two points in time (program entry and approximately 15 months later), as well as administrative wage records. The report not only summarizes the outcomes of program participants, it provides information of use for policymakers and program operators interested in funding, designing, and implementing college-based programs to train dislocated and other workers. [This report was produced in partnership with Capital Research Corporation. For the technical appendices, see ED610213.]
Published: 2020

6. Comparative study of manual identification of brain foldings in a living human brain using a proxy-endocast obtained from MRI

Author: Nicole Labra, Yann Leprince, Denis Rivière, Mathieu Santin, Jean François Mangin, Lou Albessard-Ball, Amélie Beaudet, Douglas Broadfield, Emiliano Bruner, Kristian J. Carlson, Zachary Cofran, Dean Falk, Emmanuel Gilissen, Aida Gómez-Robles, Simon Neubauer, Alannah Pearson, Carolin Röding, Yameng Zhang, Aurélien Mounier, Antoine Balzeau, Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Unité de recherche en NeuroImagerie Applicative Clinique et Translationnelle (UNIACT), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of Cambridge [UK] (CAM), University of the Witwatersrand [Johannesburg] (WITS), Department of Anthropology [Tallahassee] (FSU | Anthro), Florida State University [Tallahassee] (FSU), Royal Museum for Central Africa [Tervuren] (RMCA), Department of Anthropology [George Washington University] (GW), The George Washington University (GW), Max Planck Institute for Evolutionary Anthropology [Leipzig], and Max-Planck-Gesellschaft
Subjects: Cultural Studies, Archeology, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Anthropology, [SHS]Humanities and Social Sciences
Abstract: International audience; The use of virtual endocasts allows investigation of the folding configurations of the cerebral cortex of extinct species. However, is that really possible? Our goal is to help answer this question by qualifying and quantifying the subjective identifications of the foldings on endocasts compared to their real configurations on the brain. We invited 14 paleoneurologists to manually reconstruct the foldings they could recognize in a proxy-endocast obtained from an in-vivo MRI. MRI data were obtained on a volunteer (female, 33 y/o) during a unique session with complementary sequences. The brain structures segmentation and the folding labelling were obtained with Morphologist with the T1. The MRI UTE sequence was used to segment the bone and create the proxy-endocast with the BrainVisa software. Paleoneurologists were asked to label the endocast. Their manual reconstructions were compared with the real sulci using the Dice index in conjunction with a similarity measure based on position and shape of the foldings. Results show that foldings located closer to the base of the skull are more accurately identified in location and shape than those located in the superior region of the brain, such as the Central Sulcus that was largely misidentified and positioned closer to the precentral region. Traces that appear to be foldings but are not were also identified. The nature of some of these traces remains unknown while in particular one misidentified trace corresponds to another type of structure: the parieto-occipital suture. We hope that the information presented in this work will help the palaeoanthropology community to be more careful with the identification of foldings that might be false or largely misidentified and to validate those that are generally well reconstructed, providing support and confidence in the subsequent studies that derive from them.
Published: 2023
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7. New Seawater Dielectric Constant Parametrization and Application to SMOS Retrieved Salinity

Author: Jacqueline Boutin, Jean-Luc Vergely, Fabrice Bonjean, Xavier Perrot, Yiwen Zhou, Emmanuel P. Dinnat, Roger H. Lang, David M. Le Vine, Roberto Sabia, Processus et interactions de fine échelle océanique (PROTEO), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Analytic and Computational Research, Inc. - Earth Sciences (ACRI-ST), Swiss Federal Institute for Forest, Snow and Landscape Research WSL, NASA Goddard Space Flight Center (GSFC), Department of Mathematics [George Washington University] (GW), The George Washington University (GW), ESA Centre for Earth Observation (ESRIN), and Agence Spatiale Européenne = European Space Agency (ESA)
Subjects: [SDU]Sciences of the Universe [physics], General Earth and Planetary Sciences, Electrical and Electronic Engineering
Abstract: International audience
Published: 2023
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8. Fruit Selectivity in Anthropoid Primates: Size Matters

Author: Patrick A. Omeja, Justin A. Ledogar, Omer Nevo, Kim Valenta, David J. Daegling, Dipto Sarkar, Richard F. Kay, Manfred Ayasse, Colin A. Chapman, Sarah Bortolamiol, Urs Kalbitzer, Blythe A. Williams, University of Florida [Gainesville] (UF), Universität Ulm - Ulm University [Ulm, Allemagne], Duke University [Durham], University College Cork (UCC), McGill University = Université McGill [Montréal, Canada], Laboratoire Dynamiques Sociales et Recomposition des Espaces (LADYSS), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Makerere University Biological Field Station (MUBFS), Department of Anthropology [George Washington University] (GW), The George Washington University (GW), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Université de Paris (UP), and Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
Subjects: 0106 biological sciences, Color vision, [SDE.MCG]Environmental Sciences/Global Changes, Foraging, Zoology, 010603 evolutionary biology, 01 natural sciences, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Frugivore, Extant taxon, biology.animal, 0501 psychology and cognitive sciences, Primate, 050102 behavioral science & comparative psychology, Ecology, Evolution, Behavior and Systematics, [SHS.STAT]Humanities and Social Sciences/Methods and statistics, biology, 05 social sciences, Trichromacy, [SHS.GEO]Humanities and Social Sciences/Geography, 15. Life on land, [SDE.ES]Environmental Sciences/Environmental and Society, Animal ecology, Animal Science and Zoology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Adaptation, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Abstract: International audience; Certain features of both extant and fossil anthropoid primates have been interpreted as adaptations to ripe fruit foraging and feeding particularly spatulate incisors and trichromatic color vision. Here, we approach the question of anthropoid fruit foraging adaptations in light of the sensory and mechanical properties of anthropoid-consumed fruits in Kibale National Park, Uganda. We quantify the color, odor, size, and puncture resistance of fruits in Kibale that are consumed by anthropoid primates (N = 44) and compare these with the same traits of fruits that are not consumed by anthropoid primates (N = 24). Contrary to extant hypotheses, color and odor of anthropoid-consumed fruits do not differ from non-anthropoid–consumed fruits. However, we find that anthropoids in this system consume fruits that are significantly larger than non-anthropoid–consumed fruits, and with the exception of elephants that consume very large fruits, are the only dispersers of fruits with a surface area
Published: 2020
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9. PaleoBRAIN : ressusciter le cerveau d’Homo erectus et des Néandertaliens

Author: Balzeau, Antoine, Bardinet, Éric, Bardo, Ameline, Gilissen, Emmanuel, Gómez-Olivencia, Asier, Gómez-Robles, Aida, Heuzé, Yann, Hublin, Jean-Jacques, Hui, Jiaming, Kubicka, Anna Maria, Avila, Nicole Labra, Masi, Shelly, Mounier, Aurélien, Noûs, Camille, Pouydebat, Emmanuelle, Prima, Sylvain, Sala, Nohemi, Santin, Mathieu, Verna, Christine, Wils, Patricia, Filippo, Andréa, Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of African Zoology [Tervuren], Royal Museum for Central Africa [Tervuren] (RMCA), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Department of Anthropology [George Washington University] (GW), The George Washington University (GW), De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Department of Human Evolution [Leipzig], Max Planck Institute for Evolutionary Anthropology [Leipzig], Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Collège de France - Chaire Paléoanthropologie, Collège de France (CdF (institution)), Poznan University of Life Sciences (Uniwersytet Przyrodniczy w Poznaniu) (PULS), Éco-Anthropologie (EA), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Cogitamus, Mécanismes Adaptatifs et Evolution (MECADEV), Space-timE RePresentation, Imaging and cellular dynamics of molecular COmplexes (SERPICO), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Acquisition et Analyse de Données pour l'Histoire naturelle (2AD), and ANR-20-CE27-0009,PaleoBRAIN,Ressusciter le cerveau d'Homo erectus et des Néandertaliens(2020)
Subjects: [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [SHS]Humanities and Social Sciences
Abstract: International audience; La question de la correspondance entre les caractéristiques cérébrales et endocrâniennes est cruciale pour les applications en paléoneurologie et n’a jamais été abordée. Pour ce faire, le projet PaleoBRAIN, financé par l’ANR (ANR-20-CE27-0009), va étudier pour la première fois la corrélation entre la forme du cerveau et celle de l’endocrâne au sein d’un échantillon d’humains actuels en utilisant des acquisitions par imagerie à résonance magnétique (IRM), dont certaines avec une séquence spécifique (UTE) qui permet la caractérisation des tissus osseux. Cette contribution sera décisive pour l’étude détaillée des informations neurologiques provenant d’humains fossiles. Nous reconstruirons ensuite le cerveau d’Homo erectus et le cerveau d’Homo neanderthalensis, ainsi que leurs schémas de croissance respectifs, en tenant compte des spécificités de ces espèces. Au-delà de l’analyse détaillée des relations cerveau-endocrâne pour améliorer notre compréhension de l’anatomie des hominines fossiles, plusieurs objectifs complémentaires sont abordés. Nous analyserons les modèles de variation et de corrélation entre asymétries cérébrales et crâniennes, dont celles concernant les structures internes. Nous aborderons aussi les éventuelles relations entre asymétries du cerveau et latéralisations comportementales sur le même échantillon de volontaires. Tous ces résultats, confrontés à la variation observée chez les hominines fossiles, vont documenter les connaissances sur l’évolution du cerveau et donc sur le lien généralement supposé entre forme et fonction. Nous présentons ici les méthodes, les grands axes de recherche et les premiers résultats de ce projet qui se terminera en 2025. La pluridisciplinarité et l’interdisciplinarité seront des composantes fortes de PaleoBRAIN ainsi que des conditions essentielles pour atteindre nos objectifs scientifiques. En outre, ce projet est engagé dans une politique de science ouverte : tous les ensembles de données d’imagerie virtuelle produits seront mis à la disposition d’autres scientifiques pour leurs recherches.
Published: 2022
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10. Strengthening the Connection between Science, Society and Environment to Develop Future French and European Bioeconomies: Cutting-Edge Research of VAALBIO Team at UCCS

Author: Araque Marin, M-C. (Marcia-Carolina), Bellot Noronha, F. (Fabio), Capron, M. (Mickael), Dumeignil, F. (Franck), Friend, M. (Michèle), Heuson, E. (Egon), Itabaiana, I. (Ivaldo), Jalowiecki-Duhamel, L. (Louise), Katryniok, B. (Benjamin), Löfberg, A. (Axel), PAUL, S. (Sébastien), Wojcieszak, R. (Robert), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Instituto Nacional de Tecnologia (INT), The George Washington University (GW), ANR-16-IDEX-0004,ULNE,ULNE(2016), Université de Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, 3209|||Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181, The George Washington University [GW], and Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Subjects: catalysis, Organic Chemistry, furanics, Pharmaceutical Science, lignin, glycerol, [CHIM.CATA]Chemical Sciences/Catalysis, Analytical Chemistry, hybrid catalysis, [CHIM.POLY]Chemical Sciences/Polymers, Chemistry (miscellaneous), Drug Discovery, Molecular Medicine, Biomass, bioeconomy, polymers, Physical and Theoretical Chemistry, Hydrogen
Abstract: Le développement des futures bioéconomies françaises et européennes passe par la mise au point de nouveaux procédés de chimie verte dans lesquels les transformations catalytiques sont essentielles. L'équipe VAALBIO (valorisation des alcanes et de la biomasse) du laboratoire UCCS (Unité de Catalyse et Chimie du Solide) travaille sur différents procédés catalytiques, soit en développant de nouveaux catalyseurs et/ou en concevant l'ensemble des procédés catalytiques. Nos recherches portent à la fois sur les aspects fondamentaux et appliqués de ces procédés. Dans cet article de revue, nous présentons les principaux sujets développés par notre équipe en nous concentrant principalement sur les procédés liés à l'oxygène et à l'hydrogène, ainsi que sur la production d'hydrogène vert et la catalyse hybride. Les impacts sociaux de la bioéconomie sont également abordés en appliquant le concept de la boussole institutionnelle. The development of the future French and European bioeconomies will involve developing new green chemical processes in which catalytic transformations are key. The VAALBIO team (valorization of alkanes and biomass) of the UCCS laboratory (Unité de Catalyse et Chimie du Solide) are working on various catalytic processes, either developing new catalysts and/or designing the whole catalytic processes. Our research is focused on both the fundamental and applied aspects of the processes. Through this review paper, we demonstrate the main topics developed by our team focusing mostly on oxygen- and hydrogen-related processes as well as on green hydrogen production and hybrid catalysis. The social impacts of the bioeconomy are also discussed applying the concept of the institutional compass. 27;12
Published: 2022
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11. MASTREE+ : time-series of plant reproductive effort from six continents

Author: Andrew Hacket‐Pain, Jessie J. Foest, Ian S. Pearse, Jalene M. LaMontagne, Walter D. Koenig, Giorgio Vacchiano, Michał Bogdziewicz, Thomas Caignard, Paulina Celebias, Joep van Dormolen, Marcos Fernández‐Martínez, Jose V. Moris, Ciprian Palaghianu, Mario Pesendorfer, Akiko Satake, Eliane Schermer, Andrew J. Tanentzap, Peter A. Thomas, Davide Vecchio, Andreas P. Wion, Thomas Wohlgemuth, Tingting Xue, Katharine Abernethy, Marie‐Claire Aravena Acuña, Marcelo Daniel Barrera, Jessica H. Barton, Stan Boutin, Emma R. Bush, Sergio Donoso Calderón, Felipe S. Carevic, Carolina Volkmer de Castilho, Juan Manuel Cellini, Colin A. Chapman, Hazel Chapman, Francesco Chianucci, Patricia da Costa, Luc Croisé, Andrea Cutini, Ben Dantzer, R. Justin DeRose, Jean‐Thoussaint Dikangadissi, Edmond Dimoto, Fernanda Lopes da Fonseca, Leonardo Gallo, Georg Gratzer, David F. Greene, Martín A. Hadad, Alejandro Huertas Herrera, Kathryn J. Jeffery, Jill F. Johnstone, Urs Kalbitzer, Władysław Kantorowicz, Christie A. Klimas, Jonathan G. A. Lageard, Jeffrey Lane, Katharina Lapin, Mateusz Ledwoń, Abigail C. Leeper, Maria Vanessa Lencinas, Ana Cláudia Lira‐Guedes, Michael C. Lordon, Paula Marchelli, Shealyn Marino, Harald Schmidt Van Marle, Andrew G. McAdam, Ludovic R. W. Momont, Manuel Nicolas, Lúcia Helena de Oliveira Wadt, Parisa Panahi, Guillermo Martínez Pastur, Thomas Patterson, Pablo Luis Peri, Łukasz Piechnik, Mehdi Pourhashemi, Claudia Espinoza Quezada, Fidel A. Roig, Karen Peña Rojas, Yamina Micaela Rosas, Silvio Schueler, Barbara Seget, Rosina Soler, Michael A. Steele, Mónica Toro‐Manríquez, Caroline E. G. Tutin, Tharcisse Ukizintambara, Lee White, Biplang Yadok, John L. Willis, Anita Zolles, Magdalena Żywiec, Davide Ascoli, CAROLINA VOLKMER DE CASTILHO, CPAF-RR, PATRICIA DA COSTA, CNPMA, ANA CLAUDIA LIRA GUEDES, CPAF-AP, FERNANDA LOPES DA FONSECA, CPAF-AC, LUCIA HELENA DE OLIVEIRA WADT, CPAF-RO., Hacket-Pain, Andrew [0000-0003-3676-1568], Foest, Jessie J [0000-0002-8236-4646], Pearse, Ian S [0000-0001-7098-0495], LaMontagne, Jalene M [0000-0001-7713-8591], Koenig, Walter D [0000-0001-6207-1427], Vacchiano, Giorgio [0000-0001-8100-0659], Bogdziewicz, Michał [0000-0002-6777-9034], Caignard, Thomas [0000-0001-5009-4613], Celebias, Paulina [0000-0001-9916-2904], Fernández-Martínez, Marcos [0000-0002-5661-3610], Moris, Jose V [0000-0003-0241-7910], Palaghianu, Ciprian [0000-0003-2496-2135], Pesendorfer, Mario [0000-0002-7994-7090], Satake, Akiko [0000-0002-0831-8617], Schermer, Eliane [0000-0001-7302-2241], Tanentzap, Andrew J [0000-0002-2883-1901], Thomas, Peter A [0000-0003-3115-3301], Wion, Andreas P [0000-0002-0701-2843], Wohlgemuth, Thomas [0000-0002-4623-0894], Abernethy, Katharine [0000-0002-0393-9342], Aravena Acuña, Marie-Claire [0000-0002-4493-4396], Daniel Barrera, Marcelo [0000-0002-9207-8109], Barton, Jessica H [0000-0002-2016-4278], Boutin, Stan [0000-0001-6317-038X], Bush, Emma R [0000-0003-4036-125X], Donoso Calderón, Sergio [0000-0002-4599-4702], Carevic, Felipe S [0000-0002-6137-2057], de Castilho, Carolina Volkmer [0000-0002-1064-2758], Manuel Cellini, Juan [0000-0002-7870-5751], Chapman, Colin A [0000-0002-8827-8140], Chapman, Hazel [0000-0001-8509-703X], Chianucci, Francesco [0000-0002-5688-2060], da Costa, Patricia [0000-0002-5192-6685], Cutini, Andrea [0000-0002-7033-2399], Dantzer, Ben [0000-0002-3058-265X], Justin DeRose, R [0000-0002-4849-7744], da Fonseca, Fernanda Lopes [0000-0001-7289-6684], Gratzer, Georg [0000-0002-6355-6562], Hadad, Martín A [0000-0002-9334-064X], Herrera, Alejandro Huertas [0000-0003-2229-6714], Johnstone, Jill F [0000-0001-6131-9339], Kalbitzer, Urs [0000-0002-6289-7971], Kantorowicz, Władysław [0000-0002-2474-0113], Klimas, Christie A [0000-0001-9362-1305], Lageard, Jonathan GA [0000-0001-8971-0444], Lapin, Katharina [0000-0003-4462-2058], Ledwoń, Mateusz [0000-0003-3017-6376], Vanessa Lencinas, Maria [0000-0002-2123-3976], Lira-Guedes, Ana Cláudia [0000-0001-9200-4727], Marchelli, Paula [0000-0002-6949-0656], McAdam, Andrew G [0000-0001-7323-2572], Nicolas, Manuel [0000-0002-0885-1227], de Oliveira Wadt, Lúcia Helena [0000-0002-5018-7550], Panahi, Parisa [0000-0002-5295-9534], Martínez Pastur, Guillermo [0000-0003-2614-5403], Patterson, Thomas [0000-0002-3498-893X], Luis Peri, Pablo [0000-0002-5398-4408], Piechnik, Łukasz [0000-0002-3958-7393], Pourhashemi, Mehdi [0000-0002-8918-6336], Roig, Fidel A [0000-0003-0987-0486], Peña Rojas, Karen [0000-0001-6795-1503], Micaela Rosas, Yamina [0000-0001-7476-399X], Schueler, Silvio [0000-0003-0155-5692], Seget, Barbara [0000-0002-7872-926X], Soler, Rosina [0000-0002-5799-1672], Toro-Manríquez, Mónica [0000-0001-6492-1333], White, Lee [0000-0002-4595-5981], Yadok, Biplang [0000-0001-5926-9897], Willis, John L [0000-0003-0238-0003], Zolles, Anita [0000-0003-3476-3172], Żywiec, Magdalena [0000-0002-5992-4051], Ascoli, Davide [0000-0002-0546-4467], Apollo - University of Cambridge Repository, Department of Geography and Planning, School of Environmental Sciences, University of Liverpool, US Geological Survey [Fort Collins], United States Geological Survey [Reston] (USGS), Department of Biological Sciences [Chicago], University of Illinois [Chicago] (UIC), University of Illinois System-University of Illinois System, University of California [Berkeley] (UC Berkeley), University of California (UC), Department of Agricultural and Environmental Sciences, Università degli Studi di Milano = University of Milan (UNIMI), Laboratoire des EcoSystèmes et des Sociétés en Montagne (UR LESSEM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biodiversité, Gènes & Communautés (BioGeCo), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universitatea Stefan cel Mare Suceava (USU), Department of Forest and Soil Sciences, Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU), Kyushu University, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), ECOSYSTEMS AND GLOBAL CHANGE GROUP DEPARTMENT OF PLANT SCIENCES UNIVERSITY OF CAMBRIDGE GBR, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), School of Life Sciences, University of Northumbria at Newcastle [United Kingdom], Faculty of Natural Sciences [Stirling], University of Stirling, Universidad Nacional de la Plata [Argentine] (UNLP), Department of Biological Sciences [Edmonton], University of Alberta, Royal Botanic Garden [Edinburgh], Brazilian Agricultural Research Corporation (Embrapa), Department of Anthropology [George Washington University] (GW), The George Washington University (GW), School of biological Sciences [Christchurch], University of Canterbury [Christchurch], Centro di Viticoltura ed Enologia [CREA], Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics (CREA), Département Recherche-Développement-Innovation, Office National des Forêts (ONF), Agence Nationale des Parcs Nationaux du Gabon (ANPN), Centro de Investigación en Ecosistemas de la Patagonia (CIEP), Universidad Austral de Chile, Institute of Arctic Biology, University of Alaska [Fairbanks] (UAF), Department of Biology, University of Konstanz, Konstanz, forest research institute, Department of silviculture and genetics of forest trees, Austrian Research Centre for Forests (BFW), Department of Ecology and Evolutionary Biology [Boulder], University of Colorado [Boulder], Instituto Nacional de Tecnología Agropecuaria, and Universidad Nacional de la Patagonia Austral (UNPA)
Subjects: Plantas Perennes, Reclutamiento, demography, Seed production, Regeneración, Regeneration (biological), Q1, Perennials, Flowering, Plant Propagation, Evolución de las Estrategias Reproductivas, Ecología Vegetal, flowering, general flowering, masting, plant reproduction, recruitment, regeneration, Propagación de Plantas, General Environmental Science, Global and Planetary Change, Ecology, Ecosistemas de Tierras Secas, Reproduction, R735, Plants, [SDE]Environmental Sciences, Seeds, General flowering, Recruitment, Strategies, FOS: Medical biotechnology, demography, flowering, general flowering, masting, plant reproduction, recruitment, regeneration, Dryland Ecosystems, Plant reproduction, ddc:570, Environmental Chemistry, Demografía, Regeneration, Floración, Time Series Analysis, Ecosystem, Demography, Plant Ecology, Masting, QR, Evolution of Reproductive Strategies, FOS: Biological sciences, Análisis de Series Temporales, Estrategias
Abstract: Significant gaps remain in understanding the response of plant reproduction to environmental change. This is partly because measuring reproduction in long-lived plants requires direct observation over many years and such datasets have rarely been made publicly available. Here we introduce MASTREE+, a data set that collates reproductive time-series data from across the globe and makes these data freely available to the community. MASTREE+ includes 73,828 georeferenced observations of annual reproduction (e.g. seed and fruit counts) in perennial plant populations worldwide. These observations consist of 5971 population-level time-series from 974 species in 66 countries. The mean and median time-series length is 12.4 and 10 years respectively, and the data set includes 1122 series that extend over at least two decades (≥20 years of observations). For a subset of well-studied species, MASTREE+ includes extensive replication of time-series across geographical and climatic gradients. Here we describe the open-access data set, available as a.csv file, and we introduce an associated web-based app for data exploration. MASTREE+ will provide the basis for improved understanding of the response of long-lived plant reproduction to environmental change. Additionally, MASTREE+ will enable investigation of the ecology and evolution of reproductive strategies in perennial plants, and the role of plant reproduction as a driver of ecosystem dynamics. EEA Santa Cruz Fil: Hacket-Pain, Andrew. University of Liverpool. School of Environmental Sciences. Department of Geography and Planning; Reino Unido Fil: Foest, Jessie J. University of Liverpool. School of Environmental Sciences. Department of Geography and Planning; Reino Unido Fil: Pearse, Ian S. U.S. Fort Collins Science Center. Geological Survey; Estados Unidos Fil: LaMontagne, Jalene M. DePaul University. Department of Biological Sciences; Estados Unidos Fil: Koenig, Walter D. University of California Berkeley. Hastings Reservation; Estados Unidos Fil: Vacchiano, Giorgio. University of Milan. Milan Department of Agricultural and Environmental Sciences; Italia. Fil: Bogdziewicz, Michał. Adam Mickiewicz University. Faculty of Biology. Institute of Environmental Biology; Polonia Fil: Bogdziewicz, Michał. University Grenoble Alpes. INRAE, LESSEM; Francia Fil: Caignard, Thomas. Université Bordeaux. INRAE, BIOGECO; Francia Fil: Celebias, Paulina. Adam Mickiewicz University. Faculty of Biology. Institute of Environmental Biology; Polonia Fil: Peri, Pablo Luis. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz; Argentina. Fil: Peri, Pablo Luis. Universidad Nacional de la Patagonia Austral; Argentina. Fil: Peri, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Ascoli, Davide. University of Torino. Department of Agricultural. Forest and Food Sciences (DISAFA); Italia Fil: Gallo, Leonardo Ariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche; Argentina Fil: Gallo, Leonardo Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentina Fil: Marchelli, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche; Argentina Fil: Marchelli, Paula. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentina
Published: 2022
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12. Partial regularity in time for the space homogeneous Landau equation with Coulomb potential

Author: Golse, Fran��ois, Gualdani, Maria Pia, Imbert, Cyril, Vasseur, Alexis, Centre de Mathématiques Laurent Schwartz (CMLS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X), Department of Mathematics [George Washington University] (GW), The George Washington University (GW), Département de Mathématiques et Applications - ENS Paris (DMA), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), University of Texas at Austin [Austin], Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)
Subjects: Mathematics - Analysis of PDEs, FOS: Mathematics, Mathematics::Metric Geometry, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], 35Q20, 35B65, 35K15 (Primary) 35B44 (Secondary), Analysis of PDEs (math.AP)
Abstract: International audience; We prove that the set of singular times for weak solutions of the space homogeneous Landau equation with Coulomb potential constructed as in [C. Villani, Arch. Rational Mech. Anal. 143 (1998), 273-307] has Hausdorff dimension at most 1/2.
Published: 2021

13. Fossils from Mille-Logya, Afar, Ethiopia, elucidate the link between Pliocene environmental changes and Homo origins

Author: René Bobe, Zeresenay Alemseged, Joseph Mohan, Alan L. Deino, W. Andrew Barr, Mulugeta Alene, Shannon P. McPherron, Mark Jan Sier, Denné Reed, Jonathan G. Wynn, Denis Geraads, Diana C. Roman, University of Chicago, National Science Foundation [Arlington] (NSF), Centre de Recherche en Paléontologie - Paris (CR2P), Muséum national d'Histoire naturelle (MNHN)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Texas at Austin [Austin], Department of Anthropology [George Washington University] (GW), The George Washington University (GW), Department of Anthropology [New York University], New York University [New York] (NYU), NYU System (NYU)-NYU System (NYU), University of Oxford [Oxford], Max Planck Institute for Evolutionary Anthropology [Leipzig], Max-Planck-Gesellschaft, Berkeley Geochronology Center (BGC), Addis Ababa University (AAU), Utrecht University [Utrecht], Carnegie Institution for Science [Washington], and University of Maine
Subjects: 010506 paleontology, Geologic Sediments, Time Factors, Hominidae, Fauna, Human Migration, Biological anthropology, Science, [SDV]Life Sciences [q-bio], General Physics and Astronomy, Structural basin, 010502 geochemistry & geophysics, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, Article, Paleontology, Animals, lcsh:Science, Ledi-geraru, Ecosystem, 0105 earth and related environmental sciences, Human evolution, Multidisciplinary, biology, Geography, Fossils, Palaeontology, Palaeoecology, Hadar formation, Geology, General Chemistry, 15. Life on land, biology.organism_classification, Australopithecus, Middle awash valley, Period (geology), Paleoecology, lcsh:Q, Ethiopia, Australopithecus afarensis
Abstract: Several hypotheses posit a link between the origin of Homo and climatic and environmental shifts between 3 and 2.5 Ma. Here we report on new results that shed light on the interplay between tectonics, basin migration and faunal change on the one hand and the fate of Australopithecus afarensis and the evolution of Homo on the other. Fieldwork at the new Mille-Logya site in the Afar, Ethiopia, dated to between 2.914 and 2.443 Ma, provides geological evidence for the northeast migration of the Hadar Basin, extending the record of this lacustrine basin to Mille-Logya. We have identified three new fossiliferous units, suggesting in situ faunal change within this interval. While the fauna in the older unit is comparable to that at Hadar and Dikika, the younger units contain species that indicate more open conditions along with remains of Homo. This suggests that Homo either emerged from Australopithecus during this interval or dispersed into the region as part of a fauna adapted to more open habitats., Key events in human evolution are thought to have occurred between 3 and 2.5 Ma, but the fossil record of this period is sparse. Here, Alemseged et al. report a new fossil site from this period, Mille-Logya, Ethiopia, and characterize the geology, basin evolution and fauna, including specimens of Homo.
Published: 2020
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14. De novo and biallelic DEAF1 variants cause a phenotypic spectrum

Author: Elysa J. Marco, Heather C Mefford, Stacey McGee, Christèle Dubourg, Edmund Cauley, Randi J Hagerman, Maria J. Nabais Sá, Bert B.A. de Vries, Rüdiger Lorenz, Elizabeth E. Palmer, Michael J. Parker, Arjan P.M. de Brouwer, Hester Y. Kroes, M. Chiara Manzini, Abbey A. Scott, Tara Montgomery, Naama Orenstein, Jeanne Amiel, Delphine Héron, Leonie A. Menke, Jonathan Berg, Sylvie Odent, Rachel Harrison, Philip J. Jensik, Rani Sachdev, Miranda Splitt, Tyler Mark Pierson, Jan Maarten Cobben, Ehsan Ghayoor Karimiani, Anneke T. Vulto-vanSilfhout, Roberto Colombo, Nayana Lahiri, Julian A. Martinez-Agosto, Evan P. McNeil, Boris Keren, John M. Graham, Chanika Phornphutkul, Reza Maroofian, Radboud University Medical Center [Nijmegen], Southern Illinois University [Carbondale] (SIU), Sheffield Clinical Genetics Service, Sheffield Children's NHS Foundation Trust, St George's, University of London, Geisel School of Medicine at Dartmouth, University Medical Center [Utrecht], University of California [Davis] (UC Davis), University of California, Nottingham University Hospitals NHS Trust, Northern Genetics Service, Newcastle University [Newcastle], University of New South Wales [Sydney] (UNSW), Department of Pediatrics [Seattle, WA, USA] (Division of Genetic Medicine), University of Washington [Seattle]-Seattle Children’s Hospital, University of California [Los Angeles] (UCLA), Tel Aviv University [Tel Aviv], University of Dundee, Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Amsterdam [Amsterdam] (UvA), Cedars-Sinai Medical Center, The George Washington University (GW), Fondazione 'Policlinico Universitario A. Gemelli' [Rome], CHU Pontchaillou [Rennes], Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Warren Alpert Medical School of Brown University, University of California (UC), Nottingham University Hospitals NHS Trust (NUH), Department of Pediatrics [Seattle, WA, USA], Tel Aviv University (TAU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), General Paediatrics, Paediatric Genetics, Amsterdam Reproduction & Development (AR&D), Sheffield Children's Hospital, St George‘s, University of London, University of Washington [Seattle]-Seattle Children’s Hospital [Seattle, WA, USA], Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], George Washington University (GW), and AMS - Sports
Subjects: Adult, Male, Microcephaly, Adolescent, phenotype, Developmental Disabilities, genotype, [SDV]Life Sciences [q-bio], Mutation, Missense, Biology, Young Adult, 03 medical and health sciences, Neurodevelopmental disorder, All institutes and research themes of the Radboud University Medical Center, Genotype, medicine, Humans, Exome, Language Development Disorders, Autistic Disorder, Allele, Child, Alleles, Genetic Association Studies, Genetics (clinical), 030304 developmental biology, Genetics, 0303 health sciences, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], 030305 genetics & heredity, medicine.disease, Phenotype, neurodevelopmental disorder, Human genetics, DEAF1, DNA-Binding Proteins, intellectual disability, Child, Preschool, Speech delay, Autism, Female, medicine.symptom, Transcription Factors
Abstract: International audience; Purpose To investigate the effect of different DEAF1 variants on the phenotype of patients with autosomal dominant and recessive inheritance patterns and on DEAF1 activity in vitro. Methods We assembled a cohort of 23 patients with de novo and biallelic DEAF1 variants, described the genotype–phenotype correlation, and investigated the differential effect of de novo and recessive variants on transcription assays using DEAF1 and Eif4g3 promoter luciferase constructs. Results The proportion of the most prevalent phenotypic features, including intellectual disability, speech delay, motor delay, autism, sleep disturbances, and a high pain threshold, were not significantly different in patients with biallelic and pathogenic de novo DEAF1 variants. However, microcephaly was exclusively observed in patients with recessive variants (p < 0.0001). Conclusion We propose that different variants in the DEAF1 gene result in a phenotypic spectrum centered around neurodevelopmental delay. While a pathogenic de novo dominant variant would also incapacitate the product of the wild-type allele and result in a dominant-negative effect, a combination of two recessive variants would result in a partial loss of function. Because the clinical picture can be nonspecific, detailed phenotype information, segregation, and functional analysis are fundamental to determine the pathogenicity of novel variants and to improve the care of these patients. © 2019, American College of Medical Genetics and Genomics.
Published: 2019
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15. Declines and Resilience of Communities of Leaf Chewing Insects on Missouri Oaks Following Spring Frost and Summer Drought

Author: James B. Whitfield, John M. Landosky, Rebecca E. Forkner, Josiane Le Corff, Robert J. Marquis, John T. Lill, University of Missouri [St. Louis], University of Missouri System, The George Washington University (GW), George Mason University [Fairfax], Institut de Recherche en Horticulture et Semences (IRHS), Université d'Angers (UA)-Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Missouri Department of Conservation, USDA : 02DG 1124225 430, National Science Foundation (NSF) : 6164397., George Washington University (GW), and Université d'Angers (UA)-AGROCAMPUS OUEST-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: 0106 biological sciences, 0301 basic medicine, media_common.quotation_subject, Fauna, education, lcsh:Evolution, Climate change, drought, Insect, Biology, 010603 evolutionary biology, 01 natural sciences, Lepidoptera genitalia, Quercus, 03 medical and health sciences, Extreme weather, lcsh:QH540-549.5, lcsh:QH359-425, insect decline, Ecology, Evolution, Behavior and Systematics, media_common, spring frosts, Ecology, fungi, food and beverages, 15. Life on land, insect populations, climate change, 030104 developmental biology, Habitat, 13. Climate action, Guild, Late season, herbivorous insects, lcsh:Ecology, [SDV.EE.BIO]Life Sciences [q-bio]/Ecology, environment/Bioclimatology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract: Extreme weather events dramatically impact populations of individual insect species but the consequences of such events for entire insect communities are not well documented. We present evidence that late spring frosts and summer drought negatively affect the community of insects found on Missouri oaks (Quercus alba and Q. velutina), amounting to a 23-186 fold decrease depending on the oak species, insect size and feeding guild, and the specific weather event. Spring faunas required three years or more following spring frosts to reach pre-event levels, whereas summer faunas were more resilient, rebounding within 1-2 years. The impact of summer drought on leaf tying caterpillars, however, lasted longer than that of the spring frost; it was five years before numbers of leaf ties reached pre-drought levels. Smaller species of leaf tying Lepidoptera took longer to recover than larger species following the drought. Overall, we found no evidence for a general decline in abundance, even a modest one, during the 20 years of study of faunas on oak trees in southeastern Missouri. However, the effects of drought reported here are likely to increase with time as the climate in the Midwest U.S. is only expected to become warmer and drier during the summer months. Similarly, the risk of late season frost damage to trees is expected to increase with predicted earlier onset of spring. Understanding the impact of such weather events on insect communities influences our ability to predict how habitat and landscape management, or lack thereof, will influence future patterns of insect abundance and diversity.
Published: 2019
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16. Strongly self-interacting processes on the circle

Author: Carl-Eric Gauthier, Pierre Monmarché, Department of Mathematics, The George Washington University, Washington State University (WSU), Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Mathematics [George Washington University] (GW), and The George Washington University (GW)
Subjects: Statistics and Probability, Physics, Self-interacting Markov processes, Probability (math.PR), 010102 general mathematics, Ergodicity, almost-sure convergence, diffusions, 16. Peace & justice, 01 natural sciences, 010104 statistics & probability, Convergence of random variables, Modeling and Simulation, FOS: Mathematics, PDMP, ergodicity, Statistical physics, 0101 mathematics, Diffusion (business), [MATH]Mathematics [math], Jump process, Mathematics - Probability
Abstract: The purpose of this paper is to investigate the long time behaviour for a self-interacting diffusion and a self-interacting velocity jump process. While the diffusion case has already been studied for some particular potential function, the second one, which belongs to the family of piecewise deterministic processes, is new. Depending on the underlying potential function's shape, we prove either the almost sure convergence or the recurrence for a natural extended process given by a change a variable., 22 pages and 1 figure. Proof of Proposition 2 and proof of the first part of Theorem 1 (Section 5) have been updated. Correction of some typos
Published: 2019
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17. Observatory science with eXTP

Author: in't Zand, Jean J. M., Bozzo, Enrico, Qu, Jinlu, Li, Xiang-Dong, Amati, Lorenzo, Chen, Yang, Donnarumma, Immacolata, Doroshenko, Victor, Drake, Stephen A., Hernanz, Margarita, Jenke, Peter A., Maccarone, Thomas J., Mahmoodifar, Simin, De Martino, Domitilla, De Rosa, Alessandra, Rossi, Elena M., Rowlinson, Antonia, Sala, Gloria, Stratta, Giulia, Tauris, Thomas M., Wilms, Joern, Wu, Xuefeng, Zhou, Ping, Agudo, Iván, Altamirano, Diego, Atteia, Jean-Luc, Andersson, Nils A., Baglio, M. Cristina, Ballantyne, David R., Baykal, Altan, Behar, Ehud, Belloni, Tomaso, Bhattacharyya, Sudip, Bianchi, Stefano, Bilous, Anna, Blay, Pere, Braga, Joao, Brandt, Søren, Brown, Edward F., Bucciantini, Niccolò, Burderi, Luciano, Cackett, Edward M., Campana, Riccardo, Campana, Sergio, Casella, Piergiorgio, Cavecchi, Yuri, Chambers, Frank, Chen, Liang, Chen, Yu-Peng, Chenevez, Jérôme, Chernyakova, Maria, Jin, Chichuan, Ciolfi, Riccardo, Costantini, Elisa, Cumming, Andrew, D'Aì, Antonino, Dai, Zi-Gao, D'Ammando, Filippo, De Pasquale, Massimiliano, Degenaar, Nathalie, Del Santo, Melania, D'Elia, Valerio, Di Salvo, Tiziana, Doyle, Gerry, Falanga, Maurizio, Fan, Xilong, Ferdman, Robert D., Feroci, Marco, Fraschetti, Federico, Galloway, Duncan K., Gambino, Angelo F., Gandhi, Poshak, Ge, Mingyu, Gendre, Bruce, Gill, Ramandeep, Götz, Diego, Gouiffès, Christian, Grandi, Paola, Granot, Jonathan, Güdel, Manuel, Heger, Alexander, Heinke, Craig O., Homan, Jeroen, Iaria, Rosario, Iwasawa, Kazushi, Izzo, Luca, Ji, Long, Jonker, Peter G., José, Jordi, Kaastra, Jelle S., Kalemci, Emrah, Kargaltsev, Oleg, Kawai, Nobuyuki, Keek, Laurens, Komossa, Stefanie, Kreykenbohm, Ingo, Kuiper, Lucien, Kunneriath, Devaky, Li, Gang, Liang, En-Wei, Linares, Manuel, Longo, Francesco, Lu, Fangjun, Lutovinov, Alexander A., Malyshev, Denys, Malzac, Julien, Manousakis, Antonios, McHardy, Ian, Mehdipour, Missagh, Men, Yunpeng, Méndez, Mariano, Mignani, Roberto P., Mikusincova, Romana, Miller, M. Coleman, Miniutti, Giovanni, Motch, Christian, Nättilä, Joonas, Nardini, Emanuele, Neubert, Torsten, O'Brien, Paul T., Orlandini, Mauro, Osborne, Julian P., Pacciani, Luigi, Paltani, Stéphane, Paolillo, Maurizio, Papadakis, Iossif E., Paul, Biswajit, Pellizzoni, Alberto, Peretz, Uria, Pérez Torres, Miguel A., Perinati, Emanuele, Prescod-Weinstein, Chanda, Reig, Pablo, Riggio, Alessandro, Rodriguez, Jerome, Rodríguez-Gil, Pablo, Romano, Patrizia, Różańska, Agata, Sakamoto, Takanori, Salmi, Tuomo, Salvaterra, Ruben, Sanna, Andrea, Santangelo, Andrea, Savolainen, Tuomas, Schanne, Stéphane, Schatz, Hendrik, Shao, Lijing, Shearer, Andy, Shore, Steven N., Stappers, Ben W., Strohmayer, Tod E., Suleimanov, Valery F., Svoboda, Jir̆í, Thielemann, F.-K., Tombesi, Francesco, Torres, Diego F., Torresi, Eleonora, Turriziani, Sara, Vacchi, Andrea, Vercellone, Stefano, Vink, Jacco, Wang, Jian-Min, Wang, Junfeng, Watts, Anna L., Weng, Shanshan, Weinberg, Nevin N., Wheatley, Peter J., Wijnands, Rudy, Woods, Tyrone E., Woosley, Stan E., Xiong, Shaolin, Xu, Yupeng, Yan, Zhen, Younes, George, Yu, Wenfei, Yuan, Feng, Zampieri, Luca, Zane, Silvia, Zdziarski, Andrzej A., Zhang, Shuang-Nan, Zhang, Shu, Zhang, Shuo, Zhang, Xiao, Zingale, Michael, in ’t Zand, Jean, Drake, Stephen, Jenke, Peter, Maccarone, Thomas, Rossi, Elena, Tauris, Thomas, Andersson, Nils, Ballantyne, David, Brown, Edward, Cackett, Edward, D’Aì, Antonino, D’Ammando, Filippo, D’Elia, Valerio, Ferdman, Robert, Galloway, Duncan, Gambino, Angelo, Heinke, Craig, Jonker, Peter, Kaastra, Jelle, Lutovinov, Alexander, Mignani, Roberto, O’Brien, Paul, Osborne, Julian, Papadakis, Iossif, Pérez Torres, Miguel, Shore, Steven, Stappers, Ben, Strohmayer, Tod, Suleimanov, Valery, Torres, Diego, Watts, Anna, Weinberg, Nevin, Wheatley, Peter, Woods, Tyrone, Woosley, Stan, Zdziarski, Andrzej, in ’t Zand, Jean J. M., Bozzo, Enrico, Qu, JinLu, Li, Xiang-Dong, Amati, Lorenzo, Chen, Yang, Donnarumma, Immacolata, Doroshenko, Victor, Drake, Stephen A., Hernanz, Margarita, Jenke, Peter A., Maccarone, Thomas J., Mahmoodifar, Simin, de Martino, Domitilla, De Rosa, Alessandra, Rossi, Elena M., Rowlinson, Antonia, Sala, Gloria, Stratta, Giulia, Tauris, Thomas M., Wilms, Joern, Wu, XueFeng, Zhou, Ping, Agudo, Iván, Altamirano, Diego, Atteia, Jean-Luc, Andersson, Nils A., Baglio, M. Cristina, Ballantyne, David R., Baykal, Altan, Behar, Ehud, Belloni, Tomaso, Bhattacharyya, Sudip, Bianchi, Stefano, Bilous, Anna, Blay, Pere, Braga, João, Brandt, Søren, Brown, Edward F., Bucciantini, Niccolò, Burderi, Luciano, Cackett, Edward M., Campana, Riccardo, Campana, Sergio, Casella, Piergiorgio, Cavecchi, Yuri, Chambers, Frank, Chen, Liang, Chen, Yu-Peng, Chenevez, Jérôme, Chernyakova, Maria, Jin, ChiChuan, Ciolfi, Riccardo, Costantini, Elisa, Cumming, Andrew, D’Aì, Antonino, Dai, Zi-Gao, D’Ammando, Filippo, De Pasquale, Massimiliano, Degenaar, Nathalie, Del Santo, Melania, D’Elia, Valerio, Di Salvo, Tiziana, Doyle, Gerry, Falanga, Maurizio, Fan, XiLong, Ferdman, Robert D., Feroci, Marco, Fraschetti, Federico, Galloway, Duncan K., Gambino, Angelo F., Gandhi, Poshak, Ge, MingYu, Gendre, Bruce, Gill, Ramandeep, Götz, Diego, Gouiffès, Christian, Grandi, Paola, Granot, Jonathan, Güdel, Manuel, Heger, Alexander, Heinke, Craig O., Homan, Jeroen, Iaria, Rosario, Iwasawa, Kazushi, Izzo, Luca, Ji, Long, Jonker, Peter G., José, Jordi, Kaastra, Jelle S., Kalemci, Emrah, Kargaltsev, Oleg, Kawai, Nobuyuki, Keek, Lauren, Komossa, Stefanie, Kreykenbohm, Ingo, Kuiper, Lucien, Kunneriath, Devaky, Li, Gang, Liang, En-Wei, Linares, Manuel, Longo, Francesco, Lu, FangJun, Lutovinov, Alexander A., Malyshev, Deny, Malzac, Julien, Manousakis, Antonio, McHardy, Ian, Mehdipour, Missagh, Men, YunPeng, Méndez, Mariano, Mignani, Roberto P., Mikusincova, Romana, Miller, M. Coleman, Miniutti, Giovanni, Motch, Christian, Nättilä, Joona, Nardini, Emanuele, Neubert, Torsten, O’Brien, Paul T., Orlandini, Mauro, Osborne, Julian P., Pacciani, Luigi, Paltani, Stéphane, Paolillo, Maurizio, Papadakis, Iossif E., Paul, Biswajit, Pellizzoni, Alberto, Peretz, Uria, Pérez Torres, Miguel A., Perinati, Emanuele, Prescod-Weinstein, Chanda, Reig, Pablo, Riggio, Alessandro, Rodriguez, Jerome, Rodríguez-Gil, Pablo, Romano, Patrizia, Różańska, Agata, Sakamoto, Takanori, Salmi, Tuomo, Salvaterra, Ruben, Sanna, Andrea, Santangelo, Andrea, Savolainen, Tuoma, Schanne, Stéphane, Schatz, Hendrik, Shao, LiJing, Shearer, Andy, Shore, Steven N., Stappers, Ben W., Strohmayer, Tod E., Suleimanov, Valery F., Svoboda, Jirí, Thielemann, F.-K., Tombesi, Francesco, Torres, Diego F., Torresi, Eleonora, Turriziani, Sara, Vacchi, Andrea, Vercellone, Stefano, Vink, Jacco, Wang, Jian-Min, Wang, JunFeng, Watts, Anna L., Weng, ShanShan, Weinberg, Nevin N., Wheatley, Peter J., Wijnands, Rudy, Woods, Tyrone E., Woosley, Stan E., Xiong, ShaoLin, Xu, YuPeng, Yan, Zhen, Younes, George, Yu, WenFei, Yuan, Feng, Zampieri, Luca, Zane, Silvia, Zdziarski, Andrzej A., Zhang, Shuang-Nan, Zhang, Shu, Zhang, Shuo, Zhang, Xiao, Zingale, Michael, Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), eXTP, Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Centre de Recherche en Information Biomédicale sino-français (CRIBS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Southeast University [Jiangsu]-Institut National de la Santé et de la Recherche Médicale (INSERM), Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), ASI Science Data Center (ASDC), Italian Space Agency, INAF - Osservatorio Astronomico di Brera (OAB), Istituto Nazionale di Astrofisica (INAF), Laboratoire d'Anthropobiologie (LA), École des hautes études en sciences sociales (EHESS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astrofisico di Arcetri (OAA), SRON Netherlands Institute for Space Research (SRON), Istituto di Radioastronomia [Bologna] (IRA), KAUST Catalysis Center (KCC), King Abdullah University of Sciences & Technologie, IASF, Area di Ricerca di Tor Vergata, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), School of Physics and Astronomy [Southampton], University of Southampton, Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Institut für Astrophysik [Wien], Universität Wien, Sabanci University [Istanbul], The George Washington University (GW), Department of Physics, Tokyo Institute of Technology [Tokyo] (TITECH), Deakin University [Burwood], Copernicus Astronomical Center of the Polish Academy of Sciences (CAMK), Polish Academy of Sciences (PAN), University of New Hampshire (UNH), Department of Mechanical and Industrial Engineering [Trondheim] (MTP NTNU), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU)-Norwegian University of Science and Technology (NTNU), Ethoikos, Radicondoli, Jodrell Bank Centre for Astrophysics, University of Manchester [Manchester], Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Sichuan University [Chengdu] (SCU), University of Warwick [Coventry], U.S. Department of Energy [Washington] (DOE), University College of London [London] (UCL), Medical School (University of Nanjing), Nanjing University (NJU), Beijing Municipal Climate Center, Max-Planck-Institut für Radioastronomie (MPIFR), Laboratorio de Investigación y Formación en Informática Avanzada [La Plata] (LIFIA), Facultad de Informática [La Plata], Universidad Nacional de la Plata [Argentine] (UNLP)-Universidad Nacional de la Plata [Argentine] (UNLP), NLD, Unidad de Excelencia Científica María de Maeztu Instituto de Ciencias del Cosmos (ICCUB), MDM-2014-0369, National Natural Science Foundation of China (NSFC), European Research Council (ERC), National Aeronautics and Space Administration (NASA), Agencia Estatal de Investigación (AEI), Royal Society, Strategic Priority Research Program of the Chinese Academy of Sciences, National Science Centre, Poland (NCN), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Royal Society (UK), European Research Council, European Commission, National Natural Science Foundation of China, National Basic Research Program (China), National Science Foundation (US), Ministerio de Economía y Competitividad (España), Polish Academy of Sciences, Astronomy, Discrete Technology and Production Automation, in't Zand, Jean J. M., Qu, Jinlu, Tauris, Thomas M., Wilm, Joern, Wu, Xuefeng, Jin, Chichuan, D'Aì, Antonino, D'Ammando, Filippo, D'Elia, Valerio, Fan, Xilong, Ge, Mingyu, Lu, Fangjun, Mchardy, Ian, Men, Yunpeng, O'Brien, Paul T., Shao, Lijing, Svoboda, Jir̆í, Thielemann, F. -K., Wang, Junfeng, Weng, Shanshan, Xiong, Shaolin, Xu, Yupeng, Yu, Wenfei, Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. GAA - Grup d'Astronomia i Astrofísica, Institut de Mathématiques de Toulouse UMR5219 (IMT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Osservatorio Astronomico di Brera, Istituto di Radioastronomia (IRA), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), George Washington University (GW), Department of Mechanical and Industrial Engineering [Trondheim], Sichuan University, U.S. Department of Energy (DOE), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Université Toulouse III - Paul Sabatier (UT3), SRON Netherlands Institute for Space Research, University of Geneva, CAS - Institute of High Energy Physics, Nanjing University, INAF/IASF Bologna, National Institute for Astrophysics, University of Tübingen, NASA Goddard Space Flight Center, ICREA, University of Alabama in Huntsville, Texas Tech University, Osservatorio Astronomico di Capodimonte, Leiden University, University of Amsterdam, Polytechnic University of Catalonia, University of Urbino, Max Planck Institute for Radio Astronomy, Friedrich-Alexander University Erlangen-Nürnberg, CAS - Purple Mountain Observatory, CSIC, IRAP, New York University Abu Dhabi, Georgia Institute of Technology, Middle East Technical University, Technion-Israel Institute of Technology, Tata Institute of Fundamental Research, Roma Tre University, Instituto de Astrofísica de Canarias, Instituto Nacional de Pesquisas Espaciais, Danmarks Tekniske Universitet, Michigan State University, Osservatorio Astrofisico Di Arcetri, Florence, University of Cagliari, Wayne State University, Osservatorio Astronomico Roma, CAS - Shanghai Astronomical Observatory, Department of Electronics and Nanoengineering, Aalto-yliopisto, and Aalto University
Subjects: cataclysmic binaries, Astronomy, FIELD CAMERAS OBSERVATIONS, space research instruments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves, General Physics and Astronomy, gamma-ray burst, space research instrument, 01 natural sciences, Gamma ray bursts, Observatory, Accretion and accretion disks, Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, gravitational wave, accretion and accretion disk, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), supernova remnants, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], flare stars, gamma-ray bursts, Astrophysics::Instrumentation and Methods for Astrophysics, accretion and accretion disks, active galactic nuclei, gravitational waves, mass loss and stellar winds, nuclear astrophysics, space research instruments, X-ray binaries, X-ray bursts, Physics and Astronomy (all), Space research instruments, X ray burst, Supernova, QUIET, High mass, X-ray binarie, Mass loss and stellar winds, Nuclear astrophysics, Gamma-ray bursts, Astrophysics - High Energy Astrophysical Phenomena, PULSAR-WIND NEBULAE, FAST RADIO-BURSTS, Astrofísica nuclear, Active galactic nucleus, TIDAL DISRUPTION, Supernova remnants, Astrophysics::High Energy Astrophysical Phenomena, Polarimetry, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, ACCRETING NEUTRON-STARS, Gravitational waves, cataclysmic binarie, Settore FIS/05 - Astronomia e Astrofisica, SUPERMASSIVE BLACK-HOLES, 0103 physical sciences, 010306 general physics, X-ray burst, Astrophysics::Galaxy Astrophysics, Cataclysmic binaries, Active galactic nuclei, flare star, White dwarf, Flare stars, Stars, supernova remnant, QB460-466 Astrophysics, [SDU]Sciences of the Universe [physics], mass loss and stellar wind, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], X-RAY, Supernova remmants, X ray binaries, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], SEYFERT 1 GALAXY, nuclear astrophysic
Abstract: Disponible preprint en: arXiv:1812.04023v1 [astro-ph.HE] [v1] Mon, 10 Dec 2018 19:00:52 UTC (4,376 KB), In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry (eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.© 2018, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature., This work was supported by the Royal Society, ERC Starting (Grant No. 639217), the European Union Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Global Fellowship (Grant No. 703916), the National Natural Science Foundation of China (Grant Nos. 11233001, 11773014, 11633007, 11403074, 11333005, 11503008, and 11590781), the National Basic Research Program of China (Grant No. 2015CB857100), NASA (Grant No. NNX13AD28A), an ARC Future Fellowship (Grant No. FT120100363), the National Science Foundation (Grant No. PHY-1430152), the Spanish MINECO (Grant No. AYA2016-76012-C3-1-P), the ICCUB (Unidad de Excelencia 'Maria de Maeztu') (Grant No. MDM-2014-0369), EU's Horizon Programme through a Marie Sklodowska-Curie Fellowship (Grant No. 702638), the Polish National Science Center (Grant Nos. 2015/17/B/ST9/03422, 2015/18/M/ST9/00541, 2013/10/M/ST9/00729, and 2015/18/A/ST9/00746), the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA15020100), and the NWO Veni Fellowship (Grant No. 639.041.647).
Published: 2019
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18. The Indian-French Trishna Mission: Earth Observation in the Thermal Infrared with High Spatio-Temporal Resolution

Author: Benoit Laignel, Isabelle Dadou, Bimal K. Bhattacharya, Mathieu Gouhier, Xavier Briottet, José A. Sobrino, Albert Olioso, Philippe Gamet, Anil Kumar, Frédéric Jacob, S. K. Singh, G. Boulet, M. Irvine, Muddu Sekhar, Ratheesh Ramakrishnan, K. K. Kumar, Gérard Dedieu, Catherine Ottlé, S. Cherchali, J.-L. Roujean, S. Suresh Babu, C. S. Murthy, Olivier Hagolle, Krishna Mohan Buddhiraju, M. R. Pandya, P. V. Raju, Philippe Crebassol, M. V. Shukla, Kaniska Mallick, Jean-Pierre Lagouarde, Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique (LHEEA), École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Indian Space Research Organisation (ISRO), Centre National d'Études Spatiales [Toulouse] (CNES), Space Physics Laboratory, Centre d'études spatiales de la biosphère (CESBIO), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), ONERA / DOTA, Université de Toulouse [Toulouse], ONERA-PRES Université de Toulouse, Space technology cell (ISRO, ITT(B)), DYNBIO LEGOS, Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Groupe de Recherche en Informatique, Image, Automatique et Instrumentation de Caen (GREYC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut de Recherche pour le Développement (IRD [ Madagascar])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), School of Medicine and Health Sciences [George Washigton University] (SMHS), George Washington University (GW), Morphodynamique Continentale et Côtière (M2C), Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Institut de Physique Théorique - UMR CNRS 3681 (IPHT), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Luxembourg Institute of Science and Technology (LIST), National Remote Sensing Centre [Hyderabad] (NRSC), Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes (EMMAH), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Groupe d'étude de l'atmosphère météorologique (CNRM-GAME), Institut national des sciences de l'Univers (INSU - CNRS)-Météo France-Centre National de la Recherche Scientifique (CNRS), Indian Institute of Science, Foundation for Innovation and Technology Transfer (FITT), Indian Institute of Technology Delhi (IIT Delhi), Global Change Unit, University of Valencia, Universitat de València (UV), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), The George Washington University (GW), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rouen Normandie (UNIROUEN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Modélisation des Surfaces et Interfaces Continentales (MOSAIC), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institute of Electrical and Electronics Engineers (IEEE). USA., Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre national de recherches météorologiques (CNRM), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Interactions Sol Plante Atmosphère (ISPA), Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)-Institut National de la Recherche Agronomique (INRA), ISRO, Centre National d’Etudes Spatiales, Space Phys Lab, Vikram Sarabhai Space Ctr, Institut de Recherche pour le Développement (IRD [Réunion]), Université de Toulouse, Institut de Recherche pour le Développement (IRD), Université de Rouen Normandie (UNIROUEN), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Subjects: Earth observation, 010504 meteorology & atmospheric sciences, INFRAROUGE, CLIMATE CHANGE, WATER MANAGEMENT, 0211 other engineering and technologies, Climate change, 02 engineering and technology, 01 natural sciences, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, WATER STRESS, Water cycle, Thermal infrared, Baseline (configuration management), SATELLITE, 021101 geological & geomatics engineering, 0105 earth and related environmental sciences, Remote sensing, THERMAL, [SDE.IE]Environmental Sciences/Environmental Engineering, INFRARED, Spectral bands, MISSION SPATIALE, Natural resource, 13. Climate action, Temporal resolution, [SDE]Environmental Sciences, Environmental science, Satellite
Abstract: International audience; The monitoring of the water cycle at the Earth surface which tightly interacts with the climate change processes as well as a number of practical applications (agriculture, soil and water quality assessment, irrigation and water resource management, etc...) requires surface temperature measurements at local scale. Such is the goal of the Indian-French high spatio-temporal TRISHNA mission (Thermal infraRed Imaging Satellite for High-resolution Natural resource Assessment). The scientific objectives of the mission and research work conducted to consolidate the mission specifications are presented. Progress in modelling of surface fluxes is then discussed. The main specifications of the mission such as the revisit, the spatial resolution, the overpass time, the spectral bands and the orbit are analyzed and justified. The resulting baseline of the mission is given.
Published: 2018
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19. GENERALIZED KDV EQUATION SUBJECT TO A STOCHASTIC PERTURBATION

Author: Annie Millet, Svetlana Roudenko, Statistique, Analyse et Modélisation Multidisciplinaire (SAmos-Marin Mersenne) (SAMM), Université Paris 1 Panthéon-Sorbonne (UP1), Laboratoire de Probabilités, Statistiques et Modélisations (LPSM (UMR_8001)), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Mathematics [George Washington University] (GW), The George Washington University (GW), and NSF Carrer grant # 1151618 for Svetlana Roudenko
Subjects: Mathematics::Analysis of PDEs, Perturbation (astronomy), stochastic additive noise, symbols.namesake, Mathematics - Analysis of PDEs, Wiener process, well-posedness, Quartic function, FOS: Mathematics, Discrete Mathematics and Combinatorics, Initial value problem, Korteweg–de Vries equation, Nonlinear Sciences::Pattern Formation and Solitons, Mathematics, Primary: 60H15, 35R60, 35Q53, Secondary: 35L75, 37K10, Applied Mathematics, Mathematical analysis, Sobolev space, [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], Nonlinear system, Covariance operator, Nonlinear Sciences::Exactly Solvable and Integrable Systems, symbols, Generalized Korteweg de Vries (gKdV) equation, initial value problem, Mathematics Subject Classification 2000: Primary 60H15, 35R60, 35Q53, Secondary 35L75, 37K10, Analysis of PDEs (math.AP)
Abstract: International audience; We prove global well-posedness of the subcritical generalized Korteweg-de Vries equation (the mKdV and the gKdV with quartic power of nonlinearity) subject to an additive random perturbation. More precisely, we prove that if the driving noise is a cylindrical Wiener process on L 2 (R) and the covariance operator is Hilbert-Schmidt in an appropriate Sobolev space, then the solutions with H 1 (R) data are globally wellposed in H 1 (R). This extends results obtained by A. de Bouard and A. Debussche for the stochastic KdV equation. Dedication: In the memory of Igor Chueshov.
Published: 2018
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20. Patterns of lateral enamel growth in Homo naledi as assessed through perikymata distribution and number

Author: Lee R. Berger, Debbie Guatelli-Steinberg, Matthew M. Skinner, Donald J. Reid, Mackie C. O'Hara, Adeline Le Cabec, Lucas K. Delezene, Department of Anthropology, The Ohio State University, School of Anthropology and Conservation [University of Kent], University of Kent [Canterbury], Department of Human Evolution [Leipzig], Max Planck Institute for Evolutionary Anthropology [Leipzig], Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Department of Anthropology [University of Arkansas], University of Arkansas [Fayetteville], University of the Witwatersrand [Johannesburg] (WITS), Department of Anthropology [George Washington University] (GW), and The George Washington University (GW)
Subjects: 0301 basic medicine, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, Paranthropus robustus, 03 medical and health sciences, stomatognathic system, Homo ergaster, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Animals, 0601 history and archaeology, Dental Enamel, Australopithecus africanus, Ecology, Evolution, Behavior and Systematics, Anterior teeth, Orthodontics, 060101 anthropology, biology, Fossils, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Hominidae, 06 humanities and the arts, biology.organism_classification, Tooth enamel, stomatognathic diseases, 030104 developmental biology, medicine.anatomical_structure, Anthropology, GN, Homo erectus, Australopithecus afarensis, Paranthropus boisei
Abstract: International audience; Perikymata, incremental growth lines visible on tooth enamel surfaces, differ in their distribution and number among hominin species, although with overlapping patterns. This study asks: (1) How does the distribution of perikymata along the lateral enamel surface of Homo naledi anterior teeth compare to that of other hominins? (2) When both perikymata distribution and number are analyzed together, how distinct is H. naledi from other hominins? A total of 19 permanent anterior teeth (incisors and canines) of H. naledi were compared, by tooth type, to permanent anterior teeth of other hominins: Australopithecus afarensis, Australopithecus africanus, Paranthropus robustus, Paranthropus boisei, Homo ergaster/Homo erectus, other early Homo, Neandertals, and modern humans, with varying sample sizes. Repeated measures analyses of the percentage of perikymata per decile of reconstructed crown height yielded several statistically significant differences between H. naledi and other hominins. Canonical variates analysis of percentage of perikymata in the cervical half of the crown together with perikymata number revealed that, in 8 of 19 cases, H. naledi teeth were significantly unlikely to be classified as other hom-inins, while exhibiting least difference from modern humans (especially southern Africans). In a cross-validated analysis, 68% of the H. naledi teeth were classified as such, while 32% were classified as modern human (most often southern African). Of 313 comparative teeth use for this analysis, only 1.9% were classified as H. naledi. What tends to differentiate H. naledi anterior tooth crowns from those of most other hominins, including some modern humans, is strongly skewed perikymata distributions combined with perikymata numbers that fall in the middle to lower ranges of hominin values. H. naledi therefore tends toward a particular combination of these features that is less often seen in other hom-inins. Implications of these data for the growth and development of H. naledi anterior teeth are considered.
Published: 2018
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21. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013

Author: Meghan D. Mooney, Ken Takahashi, Andrea Stewart, Jonathan C Brown, Shireen Sindi, Amany H Refaat, Ruben Castro, Sara Sheikhbahaei, Kyle R. Heuton, Gillian M. Hansen, Chante Karimkhani, Bryan K. Phillips, Ibrahim Abubakar, Yohannes Kinfu, Victoria F Bachman, Konstantinos Stroumpoulis, Megan Coggeshall, Lucía Cuevas-Nasu, Yichong Li, Vineet K. Chadha, Andrew G. M. Bulloch, Takayoshi Ohkubo, Don C. Des Jarlais, Giancarlo Logroscino, Francis Apolinary Mhimbira, Jefferson G Fernandes, Cheng Huang, Ejaz Ahmad Khan, Fortuné Gbètoho Gankpé, Roderick J Hay, Itamar S. Santos, Zanfina Ademi, Fiona J Charlson, Norlinah Mohamed Ibrahim, Anwar Rafay, Andrew L. Thorne-Lyman, Juanita A. Haagsma, Emmanuel A. Ameh, John J. McGrath, Massimo Cirillo, Wubegzier Mekonnen, Holly Hagan, Naohiro Yonemoto, Frida Namnyak Ngalesoni, Dietrich Plass, Matias Trillini, David Phillips, Braden Te Ao, Wanqing Chen, Yun Jin Kim, David Rojas-Rueda, Christina Papachristou, Andrew E. Moran, Richard A. Gosselin, Maziar Moradi-Lakeh, Soraya Seedat, Janet L Leasher, Belinda K Lloyd, Lorenzo Monasta, Bruno F. Sunguya, Eun-Kee Park, Eduardo A. Undurraga, Mohammad A. AlMazroa, Mohammad H. Forouzanfar, Young-Ho Khang, Vasiliki Stathopoulou, Dima M. Qato, James Scott, Ileana Heredia-Pi, Luca Ronfani, Haidong Kan, Tasara T. Mazorodze, Murugesan Raju, Saeid Shahraz, Taavi Tillmann, Wang Wenzhi, Neil Pearce, Eric Y. Tenkorang, Aliya Naheed, Ferrán Catalá-López, Sudan Prasad Neupane, Emily Dansereau, Michael McKee, Derrick A Bennett, Mazeda Hossain, Paul S. F. Yip, Grant Nguyen, Norberto Perico, Miguel Angel Alegretti, Babak Eshrati, Boris Bikbov, Palwasha Anwari, Guoqing Hu, Amelia Bertozzi-Villa, Peter A. Meaney, Farshad Farzadfar, Svetlana Popova, Tara Templin, Hmwe H Kyu, Uche S. Uchendu, Kebede Deribe, Sergey Soshnikov, Nobhojit Roy, Daniel Kim, Ilana N. Ackerman, Homie Razavi, Leslie T. Cooper, Sandra Nolte, David T. Felson, John J Huang, Yang Liu, Fiorella Cavalleri, Adrian Davis, Héctor Gómez Dantés, Klara Dokova, Yuantao Hao, Catalina Medina, Austin E Schumacher, Stan Biryukov, Jane Rowley, Arindam Basu, Jose C. Adsuar, Rosana E. Norman, Yousef Khader, Rafael Alfonso-Cristancho, Sukanta Saha, Simón Barquera, Diego Gonzalez-Medina, Philip B. Mitchell, Lars Barregard, Haidong Wang, Yongmei Li, Ami R. Moore, Marie Ng, Raghib Ali, Peter T. Serina, Lijing L Yan, Ayse Abbasoglu Ozgoren, Ricky Leung, Michelle L. Bell, Tim Driscoll, Azmeraw T. Amare, Farshad Pourmalek, Tea Lallukka, Benjamin O Anderson, Raimundas Lunevicius, Corine Karema, Robert G. Weintraub, Erin C Mullany, Anders Larsson, Glen Mola, Paulo A. Lotufo, Luke Nyakarahuka, Sayed Saidul Alam, Louisa Degenhardt, Hugh R. Taylor, E. Ray Dorsey, Suzanne Polinder, Hilton Lam, Urbano Fra Paleo, David Zonies, Rahman Shiri, Marco A Avila, Alicia Elena Beatriz Lawrynowicz, Katya Anne Shackelford, Lynne Gaffikin, Konstantin Kazanjan, Mark T Mackay, Jasvinder A. Singh, Bryan L. Sykes, Sadaf G. Sepanlou, Chantal Huynh, Rakhi Dandona, Logan Sandar, Lavanya Singh, Dietrich Rothenbacher, Theo Vos, Steven E. Lipshultz, Coen H. Van Gool, Peggy P. Chiang, Mark G. Shrime, Christopher J L Murray, Scott Weichenthal, Jae-Hyun Park, Samia Alhabib, Philimon Gona, Christian Kieling, Yuichiro Yano, Ronny Westerman, Thomas Truelsen, Rajeev Gupta, Megan Bohensky, Abdullatif Husseini, Qing Lan, Luke D. Knibbs, Yousef M. Elshrek, H. Ross Anderson, Guohong Jiang, Madeline L. Moyer, Vinod K. Paul, Wim H. van Brakel, Emin Murat Tuzcu, Kara Estep, Lalit Dandona, Uchechukwu K.A. Sampson, Mohammad Tavakkoli, Ying Jiang, Joseph A Wagner, Mitsuru Mukaigawara, In-Hwan Oh, Siyi Shangguan, Noela M. Prasad, Charles D.A. Wolfe, Borja del Pozo-Cruz, Gokalp Kadri Yentur, Hilda L Harb, Elena Alvarez, Carlos A Castañeda-Orjuela, Mustafa Z. Younis, Herbert C. Duber, Erica Leigh Slepak, George A. Mensah, Knud Juel, Graeme J. Hankey, Natan M. Bornstein, Martha Híjar, Johan Ärnlöv, Mohamed Hsairi, Katherine T. Lofgren, Murray B. Stein, Renata Micha, Luigi Naldi, Margreet ten Have, Bolajoko O. Olusanya, Kyle J Foreman, Kenji Shibuya, F. Gerry R. Fowkes, Abdullah Sulieman Terkawi, Rana J. Asghar, Karen M. Tabb, Kovin Naidoo, Rogelio Pérez-Padilla, Honglei Chen, Antônio Luiz Pinho Ribeiro, Rasmus Havmoeller, Yukito Shinohara, Bongani M. Mayosi, Ernst J Kuipers, Konrad Pesudovs, Mouhanad Hammami, Lee Richardson, Rintaro Mori, Thomas D. Fleming, Pouria Heydarpour, Stephen G. Waller, Nicholas Graetz, Chanda Kulkarni, Peter Brooks, Gulfaraz Khan, Marcel Tanner, Van C. Lansingh, François Alla, Jamie Hancock, Yohannes Adama Melaku, Neeraj Bedi, Anthony D. Woolf, Tariku Jibat Beyene, Amanda W Pain, Eric L. Ding, Narayanaswamy Venketasubramanian, Semaw Ferede Abera, Devina Nand, Odgerel Chimed-Ochir, George D Thurston, Victor Aboyans, Alanur Çavlin, Jefferson Traebert, Michael R. Phillips, Yingfeng Zheng, Baffour Awuah, Carlo Irwin A. Panelo, Selen Begüm Uzun, Muhammad Imran Nisar, Samir Soneji, Veena S. Kulkarni, Mukesh Dherani, Stephen S Lim, Andre Keren, Kingsley N. Ukwaja, Sajjad Ur Rahman, Giuseppe Remuzzi, Kjetil Søreide, Blake Thomson, Samath D Dharmaratne, Christopher D. Blosser, David H. Rothstein, Amanda G. Thrift, Fabrizio Tediosi, Andrew H. Kemp, H. Dean Hosgood, Yoshihiro Kokubo, Miia Kivipelto, Amitava Banerjee, Edgar P. Simard, Reza Malekzadeh, Maggie Lind, Robert P. Dellavalle, Emerito Jose A. Faraon, Lydia S. Atkins, Tom Achoki, Aslam Pervaiz, Peter Scarborough, Hans W. Hoek, Ettore Beghi, Emilie Agardh, Abraham D. Flaxman, Dariush Mozaffarian, Juan R. Sanabria, Muluken Dessalegn, David C. Schwebel, Caitlyn Steiner, Ubai Alsharif, Richard C. Franklin, Gail Davey, Gelin Xu, Reyna A Gutiérrez, Joannie Lortet-Tieulent, Ashish Bhalla, Jost B. Jonas, Paul N. Jensen, Simon I. Hay, Xiaonong Zou, Andre Pascal Kengne, Tolesa Bekele, Brittany Wurtz, Jung-Chen Chang, Joseph Murray, Luciano A. Sposato, Stefan Ma, Summer Lockett Ohno, Charles R. Newton, Bradford D. Gessner, JianLi Wang, Scott B. Patten, Thomas Fürst, Carol Brayne, Christina Fitzmaurice, Peilin Shi, Ted R. Miller, Kinnari S. Murthy, Habib Benzian, Peter W. Gething, Cesar Diaz-Torne, Burcu Kucuk Bicer, Bo Norrving, Carly E Levitz, Adam D M Briggs, Sungroul Kim, Isabela M. Benseñor, John A. Crump, Sergey Petrovich Ermakov, Kalpana Balakrishnan, Awoke Misganaw Temesgen, Marcella Montico, Sanjay Krishnaswami, Kim Moesgaard Iburg, Ann Kristin Knudsen, Sun Ha Jee, Valery L. Feigin, Christine M. Budke, Anne Bulchis, Anand Dayama, Jonathan R. Carapetis, Cyrus Cooper, Teresa Shamah Levy, Ismael R. Campos-Nonato, Nataliya A. Foigt, Beth E. 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Dean, Hotez, Peter J, Hoy, Damian G, Huang, John J, Iannarone, Marissa L, Iburg, Kim M, Jacobsen, Kathryn H, Jarvis, Deborah L, Jassal, Simerjot K, Jensen, Paul N, Jonas, Jost B, Karema, Corine K, Kassebaum, Nicholas J, Kemp, Andrew H, Kengne, Andre P, Khader, Yousef S, Khalifa, Shams Eldin A, Khan, Ejaz A, Khang, Young Ho, Kinge, Jonas M, Knibbs, Luke D, Kuipers, Ernst J, Kulkarni, Veena S, Kumar, G. Anil, Kyu, Hmwe H, Lansingh, Van C, Lawrynowicz, Alicia E. B, Leasher, Janet L, Levitz, Carly E, Lim, Stephen S, Lipshultz, Steven E, Lloyd, Belinda K, Lofgren, Katherine T, Looker, Katharine J, Lortet Tieulent, Joannie, Lotufo, Paulo A, Lucas, Robyn M, Lyons, Ronan A, Macintyre, Michael F, Mackay, Mark T, Margolis, David J, Marzan, Melvin B, Masci, Joseph R, Mashal, Mohammad T, Mayosi, Bongani M, Mazorodze, Tasara T, Mcgill, Neil W, Mcgrath, John J, Meaney, Peter A, Melaku, Yohannes A, Memish, Ziad A, Mensah, George A, Mhimbira, Francis A, Miller, Ted R, Mills, Edward J, Mitchell, Philip B, Mock, Charles N, Mohammad, Karzan A, Mokdad, Ali H, Mola, Glen L. D, Montine, Thomas J, Mooney, Meghan D, Moore, Ami R, Moradi Lakeh, Maziar, Moran, Andrew E, Moturi, Wilkister N, Moyer, Madeline L, Msemburi, William T, Mueller, Ulrich O, Mullany, Erin C, Murdoch, Michele E, Murthy, Kinnari S, Naidoo, Kovin S, Narayan, K. M. Venkat, Neupane, Sudan P, Newton, Charles R, Ngalesoni, Frida N, Nisar, Muhammad I, Norheim, Ole F, Norman, Rosana E, Oh, In Hwan, Ohno, Summer L, Olusanya, Bolajoko O, Pain, Amanda W, Pandian, Jeyaraj D, Panelo, Carlo Irwin A, Park, Eun Kee, Park, Jae Hyun, Patten, Scott B, Patton, George C, Paul, Vinod K, Pavlin, Boris I, Pereira, David M, Perez Padilla, Rogelio, Perez Ruiz, Fernando, Peterson, Carrie B, Phillips, Michael R, Phillips, Bryan K, Phillips, David E, Piel, Frédéric B, Poulton, Richie G, Prasad, Noela M, Pullan, Rachel L, Qato, Dima M, Quistberg, D. Alex, Rahman, Sajjad U, Rana, Saleem M, Reddy, K. Srinath, Ribeiro, Antonio L, Roberts, D. Allen, Rojas Rueda, David, Roth, Gregory A, Rothstein, David H, Rowley, Jane T, Ruhago, George M, Saeedi, Mohammad Y, Sampson, Uchechukwu K. A, Sanabria, Juan R, Santos, Itamar S, Schneider, Ione J, Schumacher, Austin E, Schwebel, David C, Scott, James G, Sepanlou, Sadaf G, Serina, Peter T, Servan Mori, Edson E, Shackelford, Katya A, Shrime, Mark G, Sigfusdottir, Inga D, Silberberg, Donald H, Simard, Edgar P, Singh, Jasvinder A, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stanaway, Jeffrey D, Stein, Dan J, Stein, Murray B, Steiner, Timothy J, Stovner, Lars J, Sunguya, Bruno F, Sykes, Bryan L, Tabb, Karen M, Taylor, Hugh R, Ao, Braden J. Te, Temesgen, Awoke M, Tenkorang, Eric Y, Terkawi, Abdullah S, Thorne Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tran, Bach X, Tuzcu, Emin M, Uchendu, Uche S, Ukwaja, Kingsley N, Undurraga, Eduardo A, Uzun, Selen B, Van Brakel, Wim H, van Gool, Coen H, Vasankari, Tommi J, Violante, Francesco S, Vlassov, Vasiliy V, Wagner, Gregory R, Waller, Stephen G, Warouw, Tati S, Weintraub, Robert G, Whiteford, Harvey A, Wilkinson, James D, Williams, Thomas N, Wolfe, Charles D, Wolock, Timothy M, Woolf, Anthony D, Yan, Lijing L, Yentür, Gökalp K, Yoon, Seok Jun, Younis, Mustafa Z, Zaki, Maysaa E, Salomon, Joshua A, Lopez, Alan D, Computational Science and Engineering Department [Daresbury] ( STFC ), Science & Technologie Facilities Council, Neuroépidémiologie Tropicale ( NET ), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST ), Université de Limoges ( UNILIM ) -Université de Limoges ( UNILIM ), Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Weill Cornell Medical College - Qatar, Qatar Foundation - Education City, Doha, Maladies chroniques, santé perçue, et processus d'adaptation ( APEMAC ), Université Paris Descartes - Paris 5 ( UPD5 ) -Université de Lorraine ( UL ), Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Karolinska Institute, karolinska institute, Centro de Estudios Avanzados en Zonas Aridas ( CEAZA ), Ecole Polytechnique Fédérale de Lausanne ( EPFL ), Wisconsin Division of Public Health, Regional Genetic Service, St Mary's Hospital, Manchester, Laboratoire d'Ingénierie des Matériaux ( LIM ), Centre National de la Recherche Scientifique ( CNRS ), Computer Science Department [Bristol], University of Bristol [Bristol], Lawrence Berkeley National Laboratory [Berkeley] ( LBNL ), Samsung Research &Development Institute India - Bangalore (Groupe Samsung) ( SRI-B ), Multimedia Research Center ( MRC ), University of Alberta [Edmonton], Division of Biostatistics ( Biostat - MINNEAPOLIS ), University of Minnesota [Minneapolis], Laboratory of Neurologic Diseases, Mario Negri Institute, Milan, University of Southampton [Southampton], Imperial College London, Neurology Department, Ichilov Medical Center, Department of Public Health and Primary Care, Cambridge University, Interactions, transferts, ruptures artistiques et culturels - EA 6301 ( InTRu ), Université de Tours, Institut Jacques Monod ( IJM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Institute of Parasitology, STAR laboratory, Stanford University [Stanford], Unité de recherche Virologie et Immunologie Moléculaires ( VIM ), Institut National de la Recherche Agronomique ( INRA ), Tennent Institute of Ophthalmology, National University of Singapore ( NUS ), Multidisciplinary Nanotechnology Centre, Swansea University, Department of Computer Sciences [Scheffield], University of Sheffield [Sheffield], Cyprus International Institute for the Environment and Public Health, Harvard School of Public Health, Glasgow Centre for Physical Organic Chemistry, University of Glasgow, King‘s College London, Université Panthéon-Sorbonne - UFR Science Politique ( UP1 UFR11 ), Université Panthéon-Sorbonne ( UP1 ), National Diagnostics Centre ( NDC ), National University of Ireland [Galway] ( NUI Galway ), Arthritis Research UK Epidemiology Unit ( MANCHESTER - Arthritis Research ), University of Manchester [Manchester], CEGOT - Porto, Universidade do Porto [Porto], Advanced Laboratories on Embedded Systems [Roma] ( ALES ), Department of Biology [Miami], University of Miami [Coral Gables], Division of Human Nutrition, Wageningen University and Research Centre [Wageningen] ( WUR ), Spatial Ecology and Epidemiology Group, University of Oxford [Oxford], Department of Civil Engineering [Hamirpur], National Institute of Technology [Hamirpur], GEMMA — Environmental Engineering and Microbiology Research Group, Department of Hydraulic, Maritime and Environmental Engineering, Universitat Politècnica de Catalunya [Barcelona] ( UPC ), Institut National de Recherche et d'Analyse Physico-Chimique ( INRAP ), Institut National de Recherche et d'Analyse Physico-chimique (INRAP-Tunisie), University of Connecticut ( UCONN ), Norwegian Institute for Air Research ( NILU ), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) ( FEMTO-ST ), Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Université de Technologie de Belfort-Montbeliard ( UTBM ), Tehran University, Friedrich-Alexander Universität Erlangen-Nürnberg ( FAU ), Secretariat of the Pacific Community, Public Health Division, Sociétés, Acteurs, Gouvernement en Europe ( SAGE ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ), School of Physics and Astronomy, Washington State University ( WSU ), Laboratoire de Physique de l'ENS Lyon ( Phys-ENS ), École normale supérieure - Lyon ( ENS Lyon ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Institut de recherche en informatique de Toulouse ( IRIT ), Institut National Polytechnique [Toulouse] ( INP ) -Université Toulouse 1 Capitole ( UT1 ) -Université Toulouse - Jean Jaurès ( UT2J ) -Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique ( CNRS ), School of Computer Science - China University of Geosciences (China University of Geosciences (East Area)), Université Catholique de Louvain ( UCL ), Div Cyclotron & Radiopharmaceut Sci ( DRDO, INMAS ), Univ New Delhi, University of St Andrews [Scotland], University of Cape Town, Department of Neuroscience, Karolinska Institutet [Stockholm], Institut de Physique Nucléaire d'Orsay ( IPNO ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Computer Science and Engineering [Daejeon] (Chungnam National University), Lawrence University, Gastroenterology & Hepatology, Tata Research Development and Design Center ( TRDDC ), TCS Innovation Labs, Laboratoire MOLTECH-Anjou [Angers] ( MOLTECH ANJOU ), Université d'Angers ( UA ) -Centre National de la Recherche Scientifique ( CNRS ), University of Helsinki [Helsinki], Google Inc [Mountain View], Research at Google, Swedish Defense Research Agency ( FOI ), Centre de Recherche en Information Biomédicale sino-français ( CRIBS ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Southeast University [Jiangsu]-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratory of Image Science and Technology [Nanjing] ( LIST ), Southeast University [Jiangsu]-School of Computer Science and Engineering, Laboratoire de glaciologie et géophysique de l'environnement ( LGGE ), Observatoire des Sciences de l'Univers de Grenoble ( OSUG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ), School of Business and Informatics, University of Boras, Department of Mechanical and Automation Engineering ( CAD Laboratory ), The Chinese University of Hong Kong [Hong Kong], Università degli studi di Bari, Heuristique et Diagnostic des Systèmes Complexes [Compiègne] ( Heudiasyc ), Université de Technologie de Compiègne ( UTC ) -Centre National de la Recherche Scientifique ( CNRS ), Department of plant pathology and microbiology - centre for sustainable pest and disease management, Rothamsted Research, RGU, Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Barts and The London School of Medicine and Dentistry, Queen Mary University of London ( QMUL ), Centre d'économie de la Sorbonne ( CES ), Université Panthéon-Sorbonne ( UP1 ) -Centre National de la Recherche Scientifique ( CNRS ), Paris School of Economics ( PSE ), Istituto Dalle Molle di Studi sull'Intelligenza Artificiale ( IDSIA ), Università della Svizzera italiana ( USI ) -Scuola universitaria professionale della Svizzera italiana [Manno] ( SUPSI ), Anaesthetics, Southampton University Hospital, Department of Mathematics, University of Iowa [Iowa City], College of Medicine, Alfaisal University, Saudi Ministry of Health, Institut national des recherches agricoles du Bénin, Centre de Recherches agricoles du Sud, Departments of Epidemiology and Nutrition, Unit of Human Nutrition, Agricultural University of Athens, Department of Animal Science, PennState University [Pennsylvania] ( PSU ), University of Virginia, University of Virginia [Charlottesville], Epidemiology and Biostatistics Unit, Institute for Maternal and Child Health - IRCCS ‘‘Burlo Garofolo', Jet Propulsion Laboratory ( JPL ), NASA-California Institute of Technology ( CALTECH ), Division of Cardiovascular Medicine and Channing Division of Network Medicine, Brigham and Women's Hospital [Boston], Division of Gastroenterology and Hepatology, Department of Immunology, Mayo Clinic, Department of Chemistry, Scientific Computing Research Unit, Department of dermatology, Milano University-Azienda Ospedaleria Ospedali Riuniti di Bergamo, Department of epidemiology and Public Health, Faculty of Medicine, Hong Kong Baptist University ( HKBU ), Département Optique ( OPT ), Université européenne de Bretagne ( UEB ) -Télécom Bretagne-Institut Mines-Télécom [Paris], Department of Neurology Lunds University Hospital Lund, Services répartis, Architectures, MOdélisation, Validation, Administration des Réseaux ( SAMOVAR ), Institut Mines-Télécom [Paris]-Télécom SudParis ( TSP ) -Centre National de la Recherche Scientifique ( CNRS ), Département Réseaux et Services Multimédia Mobiles ( RS2M ), Institut Mines-Télécom [Paris]-Télécom SudParis ( TSP ), Electrical Engineering and Computer Science Department - Case Western Reserve University, Case Western Reserve University [Cleveland], Institut Lumière Matière [Villeurbanne] ( ILM ), Université Claude Bernard Lyon 1 ( UCBL ), World Health Organization, Nordic School of Public Health, The James Hutton Institute, Sero, Sero consulting, Evolutionary Ecology of Infectious Disease Group, Department of Zoology, Horia Hulubei National Institute for Physics and Nuclear Engineering, Dunedin School of Medicine, University of Otago, Department of Physics, Clarendon Laboratory, Center for TeleInFrastruktur ( CTIF ), Aalborg University [Denmark] ( AAU ), Physikalisches Institut [Freiburg], Albert-Ludwigs-Universität Freiburg, Savoirs, Textes, Langage (STL) - UMR 8163 ( STL ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Dept.of Computer Science, Indian Institute of Technology Madras ( IIT Madras ), Istituto Mario Negri Bergamo, Centro Ricerche e Trapianti Villa Camozzi, Universidade Estadual Paulista Júlio de Mesquita ( UNESP ), Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Université Grenoble Alpes - UFR Médecine ( UGA UFRM ), Université Grenoble Alpes ( UGA ), Clinical Epidemiology and Aging Research, German Cancer Research Center, Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Symantec, European Microsoft Innovation Center ( EMIC ), Microsoft Corporation [Redmond, Wash.], Laboratoire de Mécanique, Physique et Géosciences ( LMPG ), Université Le Havre Normandie ( ULH ), Normandie Université ( NU ) -Normandie Université ( NU ), Novartis institute for tropical diseases, Institut de Génétique et de Biologie Moléculaire et Cellulaire ( IGBMC ), Université de Strasbourg ( UNISTRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Departments of Anatomy and Cell Biology, Wayne State University School of Medicine, Departments of Ophthalmology, Departments of Applied Physics [New Haven], Yale University [New Haven], Center for Mathematical Modeling ( CMM ), Universidad de Santiago de Chile [Santiago] ( USACH ), Laboratory for Atmospheric and Space Physics [Boulder] ( LASP ), University of Colorado Boulder [Boulder], University of Occupational and Environmental Health [Kitakyushu] ( UEOH ), Department of Computer Science and Engineering [New Delhi], Indian Institute of Technology Delhi ( IIT Delhi ), Institut de Recherche sur les Phénomènes Hors Equilibre ( IRPHE ), Aix Marseille Université ( AMU ) -Ecole Centrale de Marseille ( ECM ) -Centre National de la Recherche Scientifique ( CNRS ), GlaxoSmithKline, Imperial College London-Clinical Imaging Center, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, Yale School of Medicine-Yale School of Medicine-Yale Stem Cell Center, Maclean Building, Benson Lane, Crowmarsh Gifford, Centre for Ecology and Hydrology, Nanoscience Institute ( NEST ), Dipartimento di Fisica, Università di Pisa, Aristotle University of Thessaloniki, Laboratory Of Immune Cell Biology ( LICB ), National Institutes of Health ( NIH ), Institute of Human Genetics, Bonn Universität [Bonn], Occupational Health Unit, Bologna University Hospital-Sant'Orsola-Malpighi Polyclinic, Royal Institute of Technology [Stockholm] ( KTH ), Institut für Informatik [München/Munich] ( LMU ), Ludwig-Maximilians-Universität München, NICTA [Eveleigh], National ICT Australia [Sydney] ( NICTA ), Manchester Academic Health Sciences Centre, Institut d'Histoire et de Philosophie des Sciences et des Techniques ( IHPST ), Université Panthéon-Sorbonne ( UP1 ) -Département d'Etudes Cognitives - ENS Paris ( DEC ), École normale supérieure - Paris ( ENS Paris ) -École normale supérieure - Paris ( ENS Paris ) -Centre National de la Recherche Scientifique ( CNRS ), Ghent University [Belgium] ( UGENT ), German Research Centre for Geosciences - Helmholtz-Centre Potsdam ( GFZ ), Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique ( LHEEA ), École Centrale de Nantes ( ECN ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche en Génie Civil et Mécanique ( GeM ), Université de Nantes ( UN ) -École Centrale de Nantes ( ECN ) -Centre National de la Recherche Scientifique ( CNRS ), Neurorestoration Group, King‘s College London-Wolfson Centre for Age-related Diseases, Department of Computer Science [KAIST] ( CS ), Korea Advanced Institute of Science and Technology ( KAIST ), Laboratoire de l'Accélérateur Linéaire ( LAL ), Natl Engn Res Ctr Vegetables, Key Lab Biol & Genet Improvement Hort Crops N Chi, Beijing Acad Agr & Forestry Sci, University Hospital Puerta de Hierro, Madrid, Computational Science and Engineering Department [Daresbury] (STFC), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Weill Cornell Medicine [Qatar], Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Centro de Estudios Avanzados en Zonas Aridas (CEAZA), Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratoire d'Ingénierie des Matériaux (LIM), Centre National de la Recherche Scientifique (CNRS), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Samsung Research &Development Institute India - Bangalore (Groupe Samsung) (SRI-B), Multimedia Research Center (MRC), University of Alberta, Division of Biostatistics (Biostat - MINNEAPOLIS), University of Minnesota [Twin Cities] (UMN), University of Minnesota System-University of Minnesota System, University of Southampton, University of Cambridge [UK] (CAM), Interactions, transferts, ruptures artistiques et culturels - EA 6301 (InTRu), Université de Tours (UT), Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Stanford University, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), National University of Singapore (NUS), Université Paris 1 Panthéon-Sorbonne - UFR Science Politique (UP1 UFR11), Université Paris 1 Panthéon-Sorbonne (UP1), National Diagnostics Centre (NDC), National University of Ireland [Galway] (NUI Galway), Arthritis Research UK Epidemiology Unit (MANCHESTER - Arthritis Research), Universidade do Porto = University of Porto, Advanced Laboratories on Embedded Systems [Roma] (ALES), Wageningen University and Research [Wageningen] (WUR), University of Oxford, Universitat Politècnica de Catalunya [Barcelona] (UPC), Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), University of Connecticut (UCONN), Norwegian Institute for Air Research (NILU), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), University of Tehran, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Sociétés, Acteurs, Gouvernement en Europe (SAGE), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), The George Washington University (GW), Washington State University (WSU), Laboratoire de Physique de l'ENS Lyon (Phys-ENS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Université Catholique de Louvain = Catholic University of Louvain (UCL), Div Cyclotron & Radiopharmaceut Sci (DRDO, INMAS), School of Physics and Astronomy [St Andrews], Tata Research Development and Design Center (TRDDC), MOLTECH-Anjou, Université d'Angers (UA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Swedish Defense Research Agency (FOI), Centre de Recherche en Information Biomédicale sino-français (CRIBS), Université de Rennes (UR)-Southeast University [Jiangsu]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratory of Image Science and Technology [Nanjing] (LIST), Laboratoire de glaciologie et géophysique de l'environnement (LGGE), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of Mechanical and Automation Engineering (CAD Laboratory), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Heuristique et Diagnostic des Systèmes Complexes [Compiègne] (Heudiasyc), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Biotechnology and Biological Sciences Research Council (BBSRC)-Biotechnology and Biological Sciences Research Council (BBSRC), Queen Mary University of London (QMUL), Centre d'économie de la Sorbonne (CES), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Paris School of Economics (PSE), Université Paris 1 Panthéon-Sorbonne (UP1)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Istituto Dalle Molle di Studi sull'Intelligenza Artificiale (IDSIA), Università della Svizzera italiana = University of Italian Switzerland (USI)-Scuola universitaria professionale della Svizzera italiana = University of Applied Sciences and Arts of Southern Switzerland [Manno] (SUPSI), Pennsylvania State University (Penn State), Penn State System-Penn State System, Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Hong Kong Baptist University (HKBU), Département Optique (OPT), Université européenne de Bretagne - European University of Brittany (UEB)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT), Services répartis, Architectures, MOdélisation, Validation, Administration des Réseaux (SAMOVAR), Institut Mines-Télécom [Paris] (IMT)-Télécom SudParis (TSP), Département Réseaux et Services Multimédia Mobiles (TSP - RS2M), University of Melbourne, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Otago [Dunedin, Nouvelle-Zélande], Center for TeleInFrastruktur (CTIF), Aalborg University [Denmark] (AAU), Savoirs, Textes, Langage (STL) - UMR 8163 (STL), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Indian Institute of Technology Madras (IIT Madras), Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), European Microsoft Innovation Center (EMIC), Laboratoire de Mécanique, Physique et Géosciences (LMPG), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU), Novartis Institute for Tropical Diseases (NITD), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Center for Mathematical Modeling (CMM), Universidad de Chile = University of Chile [Santiago] (UCHILE), Laboratory for Atmospheric and Space Physics [Boulder] (LASP), University of Colorado [Boulder], University of Occupational and Environmental Health [Kitakyushu] (UEOH), Indian Institute of Technology Delhi (IIT Delhi), Institut de Recherche sur les Phénomènes Hors Equilibre (IRPHE), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Yale University [New Haven]-Yale School of Medicine [New Haven, Connecticut] (YSM), Nanoscience Institute (NEST), University of Pisa - Università di Pisa, Laboratory Of Immune Cell Biology (LICB), National Institutes of Health [Bethesda] (NIH), Rheinische Friedrich-Wilhelms-Universität Bonn, Royal Institute of Technology [Stockholm] (KTH ), Institut für Informatik [München/Munich] (LMU), Ludwig-Maximilians-Universität München (LMU), National ICT Australia [Sydney] (NICTA), Institut d'Histoire et de Philosophie des Sciences et des Techniques (IHPST), Université Paris 1 Panthéon-Sorbonne (UP1)-Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Universiteit Gent = Ghent University (UGENT), German Research Centre for Geosciences - Helmholtz-Centre Potsdam (GFZ), Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique (LHEEA), École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Génie Civil et Mécanique (GeM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Department of Computer Science [KAIST] (CS), Korea Advanced Institute of Science and Technology (KAIST), Kardiyoloji, Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Minnesota [Twin Cities], Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Unité de recherche Virologie et Immunologie Moléculaires (VIM), Université Panthéon-Sorbonne - UFR Science Politique (UP1 UFR11), Université Panthéon-Sorbonne (UP1), Wageningen University and Research Centre [Wageningen] (WUR), Institut National de Recherche et d'Analyse Physico-chimique (Ariana, Tunisie) (INRAP), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), George Washington University (GW), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Université Catholique de Louvain (UCL), MOLTECH-ANJOU (MOLTECH-ANJOU), Université d'Angers (UA)-Centre National de la Recherche Scientifique (CNRS), University of Helsinki, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Southeast University [Jiangsu]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Università della Svizzera italiana (USI)-Scuola universitaria professionale della Svizzera italiana [Manno] (SUPSI), California Institute of Technology (CALTECH)-NASA, Institut Mines-Télécom [Paris] (IMT)-Télécom SudParis (TSP)-Centre National de la Recherche Scientifique (CNRS), Département Réseaux et Services Multimédia Mobiles (RS2M), Universidade Estadual Paulista Júlio de Mesquita Filho [São José do Rio Preto] (UNESP), Université Grenoble Alpes (UGA), Universidad de Santiago de Chile [Santiago] (USACH), Yale University [New Haven]-Yale University School of Medicine, Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris), Ghent University [Belgium] (UGENT), Université de Nantes - Faculté des Sciences et des Techniques, Grelier, Elisabeth, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Universidade do Porto, Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Toulouse 1 Capitole (UT1), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Università degli studi di Bari Aldo Moro (UNIBA), École des Ponts ParisTech (ENPC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-École des hautes études en sciences sociales (EHESS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università della Svizzera italiana = University of Italian Switzerland (USI)-Scuola universitaria professionale della Svizzera italiana [Manno] (SUPSI), Institut Mines-Télécom [Paris] (IMT)-Télécom Bretagne-Université européenne de Bretagne - European University of Brittany (UEB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Universiteit Gent = Ghent University [Belgium] (UGENT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-CHU Limoges-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM), Institut de Chimie du CNRS (INC)-Université d'Angers (UA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Nantes (ECN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Wolfson Centre for Age-related Diseases-King‘s College London, Cell biology, Public Health, Epidemiology, Health Technology Assessment (HTA), Erasmus MC other, Pathology, and Cardiothoracic Surgery
Subjects: Gerontology, Male, CHANGING RELATION, Nutrition and Disease, MESH : Life Expectancy, MESH : Aged, ECONOMIC-DEVELOPMENT, Poison control, MESH: Global Health, Global Health, Socioeconomic Factor, Communicable Disease, MESH : Chronic Disease, Health Transition, Voeding en Ziekte, Quality-Adjusted Life Year, SELF-RATED HEALTH, MESH : Socioeconomic Factors, Medicine, MESH : Female, MESH: Mortality, Premature, 2. Zero hunger, MESH: Aged, education.field_of_study, MESH: Middle Aged, Mortality rate, Medicine (all), GBD2013 diseases, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, General Medicine, Middle Aged, 3. Good health, MESH : Wounds and Injuries, Epidemiological transition, MESH: Quality-Adjusted Life Years, MESH: Communicable Diseases, NONCOMMUNICABLE DISEASES, Female, Quality-Adjusted Life Years, MESH: Life Expectancy, MESH: Health Transition, Human, MESH: Socioeconomic Factors, ACUTE MYOCARDIAL-INFARCTION, MESH : Male, MORTALITY TRENDS, Population, MESH : Health Transition, Communicable Diseases, Article, Life Expectancy, EUROPEAN-UNION, SDG 3 - Good Health and Well-being, General & Internal Medicine, SYSTEMATIC ANALYSIS, Disability-adjusted life year, Humans, Life Science, MESH : Middle Aged, Mortality, education, Premature, MESH : Mortality, Premature, VLAG, Aged, MESH: Humans, business.industry, Mortality, Premature, MESH: Chronic Disease, MESH : Communicable Diseases, Wounds and Injurie, MESH : Humans, MESH : Quality-Adjusted Life Years, Non-communicable disease, Chronic Disease, Socioeconomic Factors, Wounds and Injuries, medicine.disease, MESH: Male, LOW SOCIOECONOMIC-STATUS, Years of potential life lost, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Wounds and Injuries, Life expectancy, RISK-FACTORS, MESH : Global Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography
Abstract: Summary Background The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age–sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development. Methods We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time. Findings Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6–6·6), from 65·3 years (65·0–65·6) in 1990 to 71·5 years (71·0–71·9) in 2013, HALE at birth rose by 5·4 years (4·9–5·8), from 56·9 years (54·5–59·1) to 62·3 years (59·7–64·8), total DALYs fell by 3·6% (0·3–7·4), and age-standardised DALY rates per 100 000 people fell by 26·7% (24·6–29·1). For communicable, maternal, neonatal, and nutritional disorders, global DALY numbers, crude rates, and age-standardised rates have all declined between 1990 and 2013, whereas for non–communicable diseases, global DALYs have been increasing, DALY rates have remained nearly constant, and age-standardised DALY rates declined during the same period. From 2005 to 2013, the number of DALYs increased for most specific non-communicable diseases, including cardiovascular diseases and neoplasms, in addition to dengue, food-borne trematodes, and leishmaniasis; DALYs decreased for nearly all other causes. By 2013, the five leading causes of DALYs were ischaemic heart disease, lower respiratory infections, cerebrovascular disease, low back and neck pain, and road injuries. Sociodemographic status explained more than 50% of the variance between countries and over time for diarrhoea, lower respiratory infections, and other common infectious diseases; maternal disorders; neonatal disorders; nutritional deficiencies; other communicable, maternal, neonatal, and nutritional diseases; musculoskeletal disorders; and other non-communicable diseases. However, sociodemographic status explained less than 10% of the variance in DALY rates for cardiovascular diseases; chronic respiratory diseases; cirrhosis; diabetes, urogenital, blood, and endocrine diseases; unintentional injuries; and self-harm and interpersonal violence. Predictably, increased sociodemographic status was associated with a shift in burden from YLLs to YLDs, driven by declines in YLLs and increases in YLDs from musculoskeletal disorders, neurological disorders, and mental and substance use disorders. In most country-specific estimates, the increase in life expectancy was greater than that in HALE. Leading causes of DALYs are highly variable across countries. Interpretation Global health is improving. Population growth and ageing have driven up numbers of DALYs, but crude rates have remained relatively constant, showing that progress in health does not mean fewer demands on health systems. The notion of an epidemiological transition—in which increasing sociodemographic status brings structured change in disease burden—is useful, but there is tremendous variation in burden of disease that is not associated with sociodemographic status. This further underscores the need for country-specific assessments of DALYs and HALE to appropriately inform health policy decisions and attendant actions. Funding Bill & Melinda Gates Foundation. BACKGROUND: The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development. METHODS: We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time. FINDINGS: Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6-6·6), from 65·3 years (65·0-65·6) in 1990 to 71·5 years (71·0-71·9) in 2013, HALE at birth rose by 5·4 years (4·9-5·8), from 56·9 years (54·5-59·1) to 62·3 years (59·7-64·8), total DALYs fell by 3·6% (0·3-7·4), and age-standardised DALY rates per 100 000 people fell by 26·7% (24·6-29·1). For communicable, maternal, neonatal, and nutritional disorders, global DALY numbers, crude rates, and age-standardised rates have all declined between 1990 and 2013, whereas for non-communicable diseases, global DALYs have been increasing, DALY rates have remained nearly constant, and age-standardised DALY rates declined during the same period. From 2005 to 2013, the number of DALYs increased for most specific non-communicable diseases, including cardiovascular diseases and neoplasms, in addition to dengue, food-borne trematodes, and leishmaniasis; DALYs decreased for nearly all other causes. By 2013, the five leading causes of DALYs were ischaemic heart disease, lower respiratory infections, cerebrovascular disease, low back and neck pain, and road injuries. Sociodemographic status explained more than 50% of the variance between countries and over time for diarrhoea, lower respiratory infections, and other common infectious diseases; maternal disorders; neonatal disorders; nutritional deficiencies; other communicable, maternal, neonatal, and nutritional diseases; musculoskeletal disorders; and other non-communicable diseases. However, sociodemographic status explained less than 10% of the variance in DALY rates for cardiovascular diseases; chronic respiratory diseases; cirrhosis; diabetes, urogenital, blood, and endocrine diseases; unintentional injuries; and self-harm and interpersonal violence. Predictably, increased sociodemographic status was associated with a shift in burden from YLLs to YLDs, driven by declines in YLLs and increases in YLDs from musculoskeletal disorders, neurological disorders, and mental and substance use disorders. In most country-specific estimates, the increase in life expectancy was greater than that in HALE. Leading causes of DALYs are highly variable across countries. INTERPRETATION: Global health is improving. Population growth and ageing have driven up numbers of DALYs, but crude rates have remained relatively constant, showing that progress in health does not mean fewer demands on health systems. The notion of an epidemiological transition-in which increasing sociodemographic status brings structured change in disease burden-is useful, but there is tremendous variation in burden of disease that is not associated with sociodemographic status. This further underscores the need for country-specific assessments of DALYs and HALE to appropriately inform health policy decisions and attendant actions. FUNDING: Bill & Melinda Gates Foundation.
Published: 2015
Full Text: View/download PDF

22. Local and Global well-posedness of stochastic generalized KdV equations

Author: Millet, Annie, Roudenko, Svetlana, Statistique, Analyse et Modélisation Multidisciplinaire (SAmos-Marin Mersenne) (SAMM), Université Paris 1 Panthéon-Sorbonne (UP1), Department of Mathematics [George Washington University] (GW), The George Washington University (GW), and Millet, Annie
Subjects: [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], [MATH.MATH-PR] Mathematics [math]/Probability [math.PR], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2017

23. Metabolic transformation of microalgae due to light acclimation and genetic modifications followed by laser ablation electrospray ionization mass spectrometry with ion mobility separation

Author: Akos Vertes, Bindesh Shrestha, Eric Maréchal, Denis Falconet, Sylwia A. Stopka, Department of Chemistry, The George Washington University (GW)-W. M. Keck Institute of Proteomics Technology and Applications, Laboratoire de physiologie cellulaire végétale (LPCV), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Energy Sciences, Office of Science, U.S. Department of Energy(Grant DE-FG02-01ER15129), ANR-12-BIME-0005,DiaDomOil,Domestication des diatomées pour la production de biocarburants(2012), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), George Washington University (GW)-W. M. Keck Institute of Proteomics Technology and Applications, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), and ANR-12- BIME-0005,DiaDomOil,DiaDomOil
Subjects: Chlorophyll, Light, Metabolite, Laser ablation electrospray ionization, Chlamydomonas reinhardtii, 7. Clean energy, 01 natural sciences, Biochemistry, Analytical Chemistry, MGDG, light acclimation, genetic modifications, chemistry.chemical_compound, Microalgae, Metabolites, Electrochemistry, Spectroscopy, 0303 health sciences, education.field_of_study, biology, Chemistry, 3. Good health, Metabolome, Diacylglycerol, metabolic engineering, Aminoacids, DGDG, Chlorophyll b, Spectrometry, Mass, Electrospray Ionization, Population, Triacylglycerol, Metabolic engineering, 03 medical and health sciences, Biofuel, [CHIM]Chemical Sciences, Environmental Chemistry, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, education, 030304 developmental biology, 010401 analytical chemistry, lipid production, Glycerolipids, biology.organism_classification, 0104 chemical sciences, 13. Climate action, Phytoplankton
Abstract: International audience; Metabolic profiling of various microalga species and their genetic variants, grown under varied environmental conditions, has become critical to accelerate the exploration of phytoplankton biodiversity and biology. The accumulation of valuable metabolites, such as glycerolipids, is also sought in microalgae for biotechnological applications ranging from food, feed, medicine, cosmetics to bioenergy and green chemistry. In this report we describe the direct analysis of metabolites and lipids in small cell populations of the green alga Chlamydomonas reinhardtii, using laser ablation electrospray ionization (LAESI) mass spectrometry (MS) coupled with ion mobility separation (IMS). These microorganisms are capable of redirecting energy storage pathways from starch to neutral lipids depending on environmental conditions and nutrient availability. Metabolite and lipid productions were monitored in wild type (WT), and genetically modified C. reinhardtii strains with an impaired starch pathway. Lipids, such as triacylglycerols (TAG) and diacylglyceryl-N,N,N-trimethylhomoserine (DGTS), were monitored over time under altered light conditions. More than 200 ions related to metabolites, e.g., arginine, cysteine, serine, palmitate, chlorophyll a, chlorophyll b, etc., were detected. The lipid profiles at different light intensities for strains with impaired starch pathway (Sta1 and Sta6) contained 26 glycerolipids, such as DGTS, monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG), as well as 33 TAG species. Results were obtained over a 72 hour time period under high and low light conditions for the WT species and the two mutants. Our results indicate that LAESI-IMS-MS can be utilized for the rapid analysis of increased TAG production at elevated light intensities. Compared to WT, the Sta6 strain showed 2.5 times higher lipid production at 72 hours under high light conditions. The results demonstrate our ability to rapidly observe numerous changes in metabolite and lipid levels in microalgal population. These capabilities are expected to facilitate the exploration of genetically altered microalgal strains for biofuel production.
Published: 2014
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24. Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein

Author: Mohammed Saifuddin, Fatah Kashanchi, Renaud Mahieux, Mohit Sehgal, Bindesh Shrestha, Ravi K. Das, Myung Chung, Philippe V. Afonso, Shabana Shabbeer-Meyering, Akos Vertes, Aarthi Narayanan, Sergey Iordanskiy, Anastas Popratiloff, Rachel Van Duyne, Gavin C. Sampey, Elizabeth Jaworski, Pooja Jain, School of Systems Biology, National Center for Biodefense & Infectious Diseases-George Mason University [Fairfax], Department of Microbiology, Immunology & Tropical Medicine, The George Washington University Medical Center, Epidémiologie et Physiopathologie des Virus Oncogènes (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Department of Chemistry, The George Washington University (GW)-W. M. Keck Institute of Proteomics Technology and Applications, George Washington University Medical Center, Department of Microbiology and Immunology, Drexel University College of Medicine, Oncogenèse rétrovirale – Retroviral Oncogenesis (OR), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), This work was supported, in whole or in part,by National Institutes of Health (NIH), NCI, Grant R01 CA054559 and NIH, NIAID, Grant R01 AI077414 (supporting P. J. and M. S.) and NIH Grants AI078859, AI074410, and AI043894 (to F. K.). This work was also supported by United States Department of Energy Grant DE-SC0001599 (toF. K.),an indirect account at George MasonUniversity, and equipe labelisée Ligue Contre le Cancer (toR. M.).This work was also supported by the United States Department of Energy through Grant DE-FG02-01ER15129 (to A. V.) for conducting the LAESI-MS measurements., Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut Pasteur [Paris], Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), George Washington University (GW)-W. M. Keck Institute of Proteomics Technology and Applications, Oncogenèse rétrovirale – Retroviral Oncogenesis, Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and George Mason University [Fairfax]-National Center for Biodefense & Infectious Diseases
Subjects: MESH: Histocytochemistry, MESH: Sodium Chloride, MESH: Rats, Cell Survival, viruses, Tax, MESH: Cytoplasmic Granules, MESH: Hypothalamo-Hypophyseal System, Exosomes, Biochemistry, Exosome, Cell Line, Humans, MESH: Animals, Secretion, fas Receptor, MESH: Stress, Physiological, MESH: Pyrogens, Molecular Biology, MESH: Adrenalectomy, Human T-lymphotropic virus 1, Virulence, biology, MESH: Median Eminence, Molecular Bases of Disease, Dendritic Cells, Gene Products, tax, Cell Biology, Cell cycle, biology.organism_classification, MESH: Rats, Inbred Strains, HTLV-I Infections, MESH: Water Deprivation, MESH: Corticotropin-Releasing Hormone, Microvesicles, 3. Good health, Cell biology, MESH: Glucose, MESH: Staining and Labeling, HTLV-1, Cell culture, Apoptosis, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Host-Pathogen Interactions, biology.protein, Antibody, MESH: Female
Abstract: International audience; Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. The HTLV-1 transactivator protein Tax controls many critical cellular pathways, including host cell DNA damage response mechanisms, cell cycle progression, and apoptosis. Extracellular vesicles called exosomes play critical roles during pathogenic viral infections as delivery vehicles for host and viral components, including proteins, mRNA, and microRNA. We hypothesized that exosomes derived from HTLV-1-infected cells contain unique host and viral proteins that may contribute to HTLV-1-induced pathogenesis. We found exosomes derived from infected cells to contain Tax protein and proinflammatory mediators as well as viral mRNA transcripts, including Tax, HBZ, and Env. Furthermore, we observed that exosomes released from HTLV-1-infected Tax-expressing cells contributed to enhanced survival of exosome-recipient cells when treated with Fas antibody. This survival was cFLIP-dependent, with Tax showing induction of NF-κB in exosome-recipient cells. Finally, IL-2-dependent CTLL-2 cells that received Tax-containing exosomes were protected from apoptosis through activation of AKT. Similar experiments with primary cultures showed protection and survival of peripheral blood mononuclear cells even in the absence of phytohemagglutinin/IL-2. Surviving cells contained more phosphorylated Rb, consistent with the role of Tax in regulation of the cell cycle. Collectively, these results suggest that exosomes may play an important role in extracellular delivery of functional HTLV-1 proteins and mRNA to recipient cells.
Published: 2014
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25. The Late Neandertal permanent lower left third premolar from Walou Cave (Trooz, Belgium) and its context

Author: Stéphane Pirson, Christelle Draily, Aida Gómez-Robles, Adeline Le Cabec, Christine Verna, Michael P. Richards, Michel Toussaint, AWEM, Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Department of Human Evolution [Leipzig], Max Planck Institute for Evolutionary Anthropology [Leipzig], Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, European Synchrotron Radiation Facility (ESRF), Department of Anthropology [George Washington University] (GW), The George Washington University (GW), Direction de l'Archéologie, Department of Archaeology, Simon Fraser University, Royal Belgian Institute of Natural Sciences (RBINS), Service Public de Wallonie, and Max Planck Society
Subjects: 010506 paleontology, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Range (biology), [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Context (language use), [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, 01 natural sciences, Paleontology, Cave, Belgium, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Premolar, medicine, Animals, 0601 history and archaeology, Bicuspid, History, Ancient, 0105 earth and related environmental sciences, Neanderthals, Paleodontology, geography, 060101 anthropology, geography.geographical_feature_category, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Mousterian, 06 humanities and the arts, Archaeology, Diet, medicine.anatomical_structure, Anthropology, Upper Paleolithic, Period (geology), Anatomy
Abstract: International audience; Objectives: We describe a hominin permanent lower left third premolar unearthed in 1997 at Walou Cave (Belgium), found in direct association with a Mousterian lithic industry, in a layer directly dated to 40-38,000 years BP. Materials and methods: The taxonomical attribution of the tooth is addressed through comparative morphometric analyses, and stable isotope analyses aimed at determining the diet of the individual. Results: The Walou P 3 plots within the Neandertal range of variation and is significantly different from recent modern humans in all morphometric assessments. The isotope data showed that like other Neandertals, the Walou individual acquired its dietary proteins primarily from terrestrial food sources. Discussion: We discuss the implications of the existence of a clearly Neandertal premolar dating to the period of the Middle to Upper Paleolithic transition in the Meuse river basin. K E Y W O R D S diet, MIS 3, Mousterian, Neandertal, tooth
Published: 2017
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26. Space as a Tool for Astrobiology: Review and Recommendations for Experimentations in Earth Orbit and Beyond

Author: Cottin, Hervé, Kotler, Julia Michelle, Billi, Daniela, Cockell, Charles, Demets, René, Ehrenfreund, Pascale, Elsaesser, Andreas, d’Hendecourt, Louis, van Loon, Jack J. W. A., Martins, Zita, Onofri, Silvano, Quinn, Richard C., Rabbow, Elke, Rettberg, Petra, Ricco, Antonio J., Slenzka, Klaus, de la Torre, Rosa, de Vera, Jean-Pierre, Westall, Frances, Carrasco, Nathalie, Fresneau, Aurélien, Kawaguchi, Yuko, Kebukawa, Yoko, Nguyen, Dara, Poch, Olivier, Saiagh, Kafila, Stalport, Fabien, Yamagishi, Akihiko, Yano, Hajime, Klamm, Benjamin A., Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Fachbereich Biologie [Konstanz], University of Konstanz, Chemical Analysis Facility (CAF), University of Reading (UOR), Università degli Studi di Roma Tor Vergata [Roma], SUPA School of Physics and Astronomy [Edinburgh], University of Edinburgh, European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Space Policy Institute [Washington], The George Washington University (GW), Leiden Institute of Chemistry, Experimental Molecular Biophysics [Berlin], Fachbereich Physik [Freie Univeristät Berlin] | Department of Physics [Freie Univeristät Berlin], Freie Universität Berlin-Freie Universität Berlin, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), VU University Medical Center [Amsterdam], Department of Earth Science and Technology [Imperial College London], Imperial College London, Università degli studi della Tuscia [Viterbo], NASA Ames Research Center (ARC), DLR Institut für Luft- und Raumfahrtmedizin, Deutsches Zentrum für Luft- und Raumfahrt [Köln] (DLR), Orbitale Hochtechnologie Bremen (OHB Systems AG), Jacobs University [Bremen], Instituto Nacional de Técnica Aeroespacial (INTA), DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Tokyo University of Pharmacy and Life Sciences (TUPLS), Yokohama National University, Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency [Sagamihara] (JAXA), ESACNESANRCNRS (CNRS-MI-2014), European Project: 636829,H2020,ERC-2014-STG,PRIMCHEM(2015), European Project: 607297,EC:FP7:SPA,FP7-SPACE-2013-1,MASE(2014), Fachbereich Physik [Berlin], OHB Systems AG, Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), The Royal Society, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), George Washington University (GW), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), IMPEC - LATMOS, Universiteit Leiden, Agence Spatiale Européenne = European Space Agency (ESA), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES)
Subjects: [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Settore BIO/01, Cubesat, Hardware for space experiments, Astronomy & Astrophysics, Astrobiology, International Space Station, Tanpopo, 0201 Astronomical And Space Sciences, Space environment, Nanosatellites, Exobiology, Astrochemistry, BIOPAN, STONE, EXPOSE
Abstract: International audience; The space environment is regularly used for experiments addressing astrobiology research goals. The specific conditions prevailing in Earth orbit and beyond, notably the radiative environment (photons and energetic particles) and the possibility to conduct long-duration measurements, have been the main motivations for developing experimental concepts to expose chemical or biological samples to outer space, or to use the reentry of a spacecraft on Earth to simulate the fall of a meteorite. This paper represents an overview of past and current research in astrobiology conducted in Earth orbit and beyond, with a special focus on ESA missions such as Biopan, STONE (on Russian FOTON capsules) and EXPOSE facilities (outside the International Space Station). The future of exposure platforms is discussed, notably how they can be improved for better science return, and how to incorporate the use of small satellites such as those built in cubesat format
Published: 2017
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27. Decay of COSAC and Ptolemy mass spectra at comet 67P/Churyumov-Gerasimenko

Author: Cyril Szopa, Pascale Ehrenfreund, Harald Krüger, Thomas Gautier, Jan Hendrik Bredehöft, Stephan Ulamec, Chaitanya Giri, François Raulin, Harald Steininger, Ian Wright, Susan McKenna-Lawlor, Barbara Cozzoni, Fred Goesmann, Andrew Morse, Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, Earth-Life Science Institute [Tokyo] (ELSI), Tokyo Institute of Technology [Tokyo] (TITECH), School of Physical Sciences [Milton Keynes], The Open University [Milton Keynes] (OU), Institut für Angewandte und Physikalische Chemie (IAPC), Universität Bremen, Deutsches Zentrum für Luft- und Raumfahrt (DLR), Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Space Policy Institute [Washington], George Washington University (GW), Center for Research and Exploration in Space Science and Technology [GSFC] (CRESST), NASA Goddard Space Flight Center (GSFC), Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Space Technology Ireland Limited, Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), IMPEC - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), German Bundesministerium für Wirtschaft und Energie, CNES, Faculty of Science, Technology, Engineering and Mathematics [Milton Keynes], The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), The George Washington University (GW), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), PLANETO - LATMOS, Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Universiteit Leiden, and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
Subjects: 010504 meteorology & atmospheric sciences, Comet, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], astrobiology, FOS: Physical sciences, Astrophysics, Mass spectrometry, Comets individual: 67P/Churyumov-Gerasimenko, 01 natural sciences, Spectral line, Ion, Comet nucleus, 0103 physical sciences, space vehicles: instruments, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Earth and Planetary Astrophysics (astro-ph.EP), Physics, astrochemistry, comets: individual: 67P/Churyumov-Gerasimenko - comets: General, Astronomy and Astrophysics, Regolith, Nutzerzentrum für Weltraumexperimente (MUSC), Comets: general, 13. Climate action, Space and Planetary Science, Mass spectrum, Astrophysics - Earth and Planetary Astrophysics
Abstract: The Rosetta lander Philae successfully landed on the nucleus of comet 67P/Churyumov-Gerasimenko on 12 November 2014. Philae is equipped with two gas analyzers: The Cometary Sampling and Composition experiment (COSAC) and the gas chromatograph and mass spectrometer Ptolemy. On 12 to 14 November 2014 both instruments measured the organic composition of the comet nucleus material through seven measurements in sniffing mode during Philae's hopping and at its final landing site Abydos. We compare the temporal evolution of intensities of several ion species identified by both mass spectrometers. For COSAC this is the first analysis of the temporal behaviour of the measured ion species. All ion species showed the highest intensities in the first spectra measured by both instruments about 20 to 30 minutes after Philae's first touchdown at Agilkia, and a decay during the six consecutive measurements at Abydos. Both instruments measured a nearly identical decay of the water peak (m/z 18), and also CO (m/z 28) behaved similarly. In the COSAC measurements the peak at m/z 44 decays much slower than all the other ion species, including the water peak. In particular, the m/z 44 peak decays much slower in the COSAC measurements than in the Ptolemy data. This supports our earlier interpretation that COSAC for the first time analyzed a regolith sample from a cometary nucleus in situ, while Ptolemy measured cometary gas from the ambient coma. The m/z 44 peak measured by COSAC was likely dominated by organic species, whereas the peak measured by Ptolemy was interpreted to be mostly due to $CO_2$. Ion species heavier than m/z 30 tend to decay somewhat slower in the COSAC measurements than in the Ptolemy data, which may be related to differences in the exhaust designs between both instruments., Comment: 7 pages, 4 figures, Astronomy and Astrophysics in press
Published: 2017
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28. Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Author: Gerald M. Mkoji, Ittiprasert Wannaporn, Xiao-Jun Wu, Julia B. Carleton, Gloria I. Giraldo-Calderón, Matty Knight, Catherine S. Jones, Anthony T. Papenfuss, Elio Hideo Baba, Brian J. Raney, Richard M. Cripps, Christine Coustau, Martin T. Swain, René Feyereisen, Judith E. Humphries, Nithya Raghavan, Kathryn M. Ryan, Céline Cosseau, Karl F. Hoffmann, Michael S. Blouin, Edwin J. Routledge, TyAnna L. Lovato, Min Zhao, Olga Baron, Fabiano Sviatopolk-Mirsky Pais, Mikkel Christensens, Sandra W. Clifton, Leonid L. Moroz, Maria G. Castillo, Damian L. Trujillo, Donald P. McManus, Emanuela V. Volpi, Liana K. Jannotti-Passos, Scott P Lawton, Joanna M. Bridger, Yesid Cuesta-Astroz, Eric S. Loker, David Duval, Fernanda Ludolf, Bronwyn Rotgans, Mónica Medina, Di Liang, Benjamin Gourbal, Izinara C Rosse, Catrina Fronick, Sarah K. Buddenborg, Roberta Lima Caldeira, Umar Niazi, Aurélie Kapusta, Christoph Grunau, Scott F. Cummins, Katherine M. Buckley, Milind Misra, Matheus de Souza Gomes, LaDeana W. Hillier, Iain W. Chalmers, Guillaume Mitta, Scott J. Emrich, Kathrin K. Geyer, Wander de Jesus Jeremias, Larissa L. S. Scholte, Laurence Rodrigues do Amaral, Juliana G Assis, Jacob A. Tennessen, Emmanuel A. Pila, Patrick C. Hanington, Andrew M. Shedlock, Wesley C. Warren, Chris Botka, Sandra Grossi Gava, Coen M. Adema, Janeth J. Pena, Satwant Kaur, Chad Tomlinson, Richard Galinier, Michelle A. Gordy, Bishoy Kamel, Guilherme Oliveira, Anne E. Lockyer, Jonathan P. Rast, Andrea B. Kohn, Daniel Lawson, Richard K. Wilson, Patrick Minx, Bryony C. Bonning, Peter C. FitzGerald, Christopher J. Bayne, Omar dos Santos Carvalho, Monica Munoz-Torres, Tianfang Wang, David Rollinson, Vince Magrini, Kyle K. Biggar, Titouan Quelais, Leslie R. Noble, Utibe Bickham-Wright, Francislon Silva de Oliveira, Cédric Feschotte, Daniel J. Jackson, Joris M. Koene, Michael J. Montague, Anthony J. Walker, Lucinda Fulton, Daniel S.T. Hughes, Susan Jobling, Rob Peace, Halime D. Arican-Goktas, Nathalie Dinguirard, Timothy P. Yoshino, Mohammed Yusuf, Cesar E. Montelongo, Michael E. Geusz, Sijun Liu, Si-Ming Zhang, Kenneth B. Storey, Leon di Stephano, Yanin Limpanont, Center for Evolutionary and theoretical Immunology, Biology, The University of New Mexico [Albuquerque], The McDonnell Genome Institute (MGI), Washington University in St Louis, INSTITUTE OF BIOLOGICAL AND ENVIRONMENTAL SCIENCES, University of Aberdeen, Department of Microbiology, Immunology & Tropical Medicine and Research Center for Neglected Diseases of Poverty, George Washington University (GW), Division of Science & Mathematics, University of the District of Columbia, Fiocruz Minas - René Rachou Research Center / Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), sans affiliation, Biology Department, Medical University of South Carolina [Charleston] (MUSC), Laboratory of Bioinformatics and Molecular Analysis, Federal University of Uberlândia [Uberlândia] (UFU), Department of Life Sciences, College of Health and Life Sciences, Brunel University London [Uxbridge], Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Department of Integrative Biology, Oregon State University (OSU), Department of Pathobiological Sciences, University of Wisconsin-Madison, Institute of Biochemisty and Department of Biology, Carleton University, Iowa State University (ISU), Department of Information Technology, Harvard Medical School, Harvard Medical School [Boston] (HMS), Sunnybrook Health Sciences Centre, Department of Immunology, University of Toronto, Department of Human Genetics [Salt Lake City], University of Utah, Biology, New Mexico State University, New Mexico State University, Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, EMBL-EBI, Wellcome Genome Campus, Interactions Hôtes-Pathogènes-Environnements (IHPE), Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Faculty of Science, Health and Education, University of the Sunshine Coast, The Walter and Eliza Hall Institute for Medical Research (WEHI), Genomics and Bioinformatics Core Facility, University of Notre Dame [Indiana] (UND), Department of Plant and Environmental Sciences [Copenhagen], Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Genome Analysis Unit, National Cancer Institute, National Institutes of Health [Bethesda] (NIH), Biological Sciences, Bowling Green State University, Bowling Green State University, IBERS, Institute of Biological, Environmental and Rural Sciences, Biotechnology and Biological Sciences Research Council, Department of Public Health Sciences, University of Alberta, University of Alberta, Department of Biology, Lawrence University, Lawrence University, Courant Research Centre Geobiology, Georg-August University of Göttingen, Georg-August-University [Göttingen], Institute of Environment, Health & Societies, Environment and Health Theme, Brunel University London, Brunel University London, Department of Biology, Pennsylvania State University (Penn State), Penn State System-Penn State System, Faculteit der Aard- en Levenswetenschappen, Vrije Universiteit, Vrije Universiteit Amsterdam [Amsterdam] (VU), The Whitney Laboratory for Marine Bioscience, University of Florida, University of Florida [Gainesville], Molecular Parasitology Laboratory, Kingston University, Kingston University, Faculty of Science, Health, Education and Engineering (USC), Molecular Parasitology Unit, Queensland Institute of Medical Research, Penn State System, Kenya Medical Research Institute (KEMRI), Department of Neuroscience (DEPARTMENT OF NEUROSCIENCE), University of Pennsylvania [Philadelphia], Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Bioinformatics and Cancer Genomics lab Lorenzo and Pamela Galli, Melanoma Research Fellow Peter MacCallum Cancer Centre, Institute for Genomics and Bioinformatics [Irvine], University of California [Irvine] (UCI), University of California-University of California, Parasites and Vectors Division, London Centre for Neglected Tropical Disease Research, Natural History Museum, Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster [London] (UOW), Molecular Parasitology Laboratory, School of Life Sciences Pharmacy and Chemistry, Sequence characterization of the Biomphalaria glabrata genome was funded by NIH-NHGRI grant HG003079 to R.K.W., McDonnell Genome Institute, Washington University School of Medicine. Biomphalaria glabrata and Schistosoma mansoni were provided to some participating labs by the NIAID Schistosomiasis Resource Center (Biomedical Research Institute, Rockville, MD) through NIH-NIAID Contract HHSN272201000005I for distribution through BEI Resources. C.M.A. and E.S.L. acknowledge NIH grant P30GM110907 from the National Institute of General Medical Sciences (NIGMS). Publication costs were contributed equally by McDonnell Genome Institute, Washington University School of Medicine and the COBRE Center for Evolutionary and Theoretical Immunology (CETI) which is supported by NIH grant P30GM110907 from the National Institute of General Medical Sciences (NIGMS). E.S.L. acknowledges NIH/NIAID ROI AI101438. J.M.B., H.D.A.-G and M.K. acknowledge NIH-NIAID R01-AI0634808. M.Y. acknowledges UK BBSRC (BB/H022597/1). G.O. acknowledges support from FAPEMIG (RED-00014-14, PPM-00189-13) and CNPq (304138/2014-2, 309312/2012-4). R.L.C. acknowledges CNPq (503275/2011-5). T.P.Y. acknowledges NIH/NIAID RO1AI015503. K.F.H. and M.T.S. acknowledge BBSRC (BB/K005448/1). B.G. acknowledges ANR JCJC INVIMORY (ANR-13-JSV7-0009). S.E. acknowledges NIAID contract HHSN272201400029C. J.M.K. acknowledges the Research Council for Earth and Life Sciences (A.L.W., 819.01.007) and the Netherlands Organization for Scientific Research (NWO). R.M.C. acknowledges NIH GM061738 and support from the American Heart Association, Southwest Affiliate (14GRNT20490250). D.T. acknowledges NIH R25 GM075149. C.F. acknowledges NIH R01-GM077582. D.J.J. acknowledges D.F.G. JA2108/1-2. M.de S.G. acknowledges CNPq 479890/2013-7. K.M.B. and J.P.R. acknowledge NSERC 312221 and CIHR MOP74667. C.S.J., L.R.N., S.J., E.J.R., S.K. and A.E.L. acknowledge NC3R GO900802/1. K.K.B. and K.B.S. acknowledge NSERC 315051 and 6793, respectively. M.B. and C.J.B. acknowledge NIH RO1-AI109134. C.J.B. acknowledges NIH AI016137 and AI111201. B.R. acknowledges NHGRI 4U41HG002371. P.C.H., M.A.G. and E.A.P. acknowledge NSERC 418540. O.L.B. and Ch.C. acknowledge ANR-12-EMMA-0007-01. S.F.C. acknowledges Australian Research Council FT110100990., We thank S. Newfeld for discussion of actin evolution, N. El Sayed and H. Tettelin for discussion of HSP annotation and expression. We acknowledge access to the Metafer microscopy system at the I. Robinson Research Complex, Harwell, Rutherford Appleton Laboratory, Oxon, UK (BBSRC Professorial Fellowship, grant number BB/H022597/1)., Washington University in Saint Louis (WUSTL), The George Washington University (GW), Fiocruz Minas - René Rachou Research Center / Instituto René Rachou [Belo Horizonte, Brésil], Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Perpignan Via Domitia (UPVD), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Florida [Gainesville] (UF), Animal Ecology, and Adema, Coen M.
Subjects: 0301 basic medicine, MESH: Sequence Analysis, DNA, Proteome, INTERMEDIATE HOST, MESH: Schistosoma mansoni, General Physics and Astronomy, Biomphalaria, Fresh Water, Snail, Genome informatics, Genome, Freshwater snail, Pheromones, MESH: Biomphalaria/parasitology, 0302 clinical medicine, Global health, ACTIN GENES, MESH: Animals, DNA sequencing, MESH: Stress, Physiological, MESH: Evolution, Molecular, MESH: Pheromones, Multidisciplinary, biology, INVERTEBRATE, schistosomiase, Schistosoma mansoni, Corrigenda, MESH: Gene Expression Regulation, 6. Clean water, Multidisciplinary Sciences, MESH: Proteome, MESH: DNA Transposable Elements, MESH: Fresh Water, Science & Technology - Other Topics, MESH: Animal Communication, Science, 030231 tropical medicine, MANSONI, Zoology, Schistosomiasis, MESH: Host-Parasite Interactions, General Biochemistry, Genetics and Molecular Biology, Article, Host-Parasite Interactions, Evolution, Molecular, 03 medical and health sciences, Stress, Physiological, biology.animal, MESH: Schistosomiasis mansoni/transmission, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], MD Multidisciplinary, parasitic diseases, medicine, Journal Article, Biomphalaria glabrata, Animals, MESH: Biomphalaria/genetics, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, BIOMPHALARIA-GLABRATA, Science & Technology, COMPLEXITY, escargot aquatique, MESH: Genome, fungi, RECOGNITION, General Chemistry, Sequence Analysis, DNA, biology.organism_classification, medicine.disease, bacterial infections and mycoses, EVOLUTION, Schistosomiasis mansoni, Animal Communication, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, 030104 developmental biology, Gene Expression Regulation, MESH: Biomphalaria/immunology, INNATE IMMUNITY, DNA Transposable Elements, VERTEBRATE, biological
Abstract: Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis., Biomphalaria glabrata is a fresh water snail that acts as a host for trematode Schistosoma mansoni that causes intestinal infection in human. This work describes the genome and transcriptome analyses from 12 different tissues of B glabrata, and identify genes for snail behavior and evolution.
Published: 2017
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29. Measuring the expansion velocity of the outflows of LS I +61 303 through low-frequency radio observations

Author: Marcote, B., Ribó, M., Paredes, J.M., Ishwara-Chandra, C.H., Swinbank, J.D., Broderick, J.W., Markoff, S., Fender, R., Wijers, R.A.M.J., Pooley, G.G., Stewart, A.J., Bell, M.E., Breton, R.P., Carbone, D., Corbel, S., Eislöffel, J., Falcke, H., Grießmeier, J.-M., Kuniyoshi, M., Pietka, M., Rowlinson, A., Serylak, M., van der Horst, A.J., van Leeuwen, J., Wise, M.W., Zarka, P., Aharonian, F.A., Hofmann, W., Rieger, F.M., High Energy Astrophys. & Astropart. Phys (API, FNWI), Institut de Ciencies del Cosmos (ICCUB), Universitat de Barcelona (UB), National Centre for Radio Astrophysics [Pune] (NCRA), Tata Institute of Fundamental Research [Bombay] (TIFR), Department of Astrophysical Sciences [Princeton], Princeton University, University of Southampton, Sub-department of Astrophysics [Oxford], Department of Physics [Oxford], University of Oxford [Oxford]-University of Oxford [Oxford], Anton Pannekoek Institute for Astronomy, University of Amsterdam [Amsterdam] (UvA), Mullard Radio Astronomy Observatory (MRAO), University of Cambridge [UK] (CAM), CSIRO Astronomy and Space Science, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Jodrell Bank Centre for Astrophysics, University of Manchester [Manchester], Unité Scientifique de la Station de Nançay (USN), Université d'Orléans (UO)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Thüringer Landessternwarte Tautenburg (TLS), Institute for Mathematics, Astrophysics and Particle Physics (IMAPP), Radboud university [Nijmegen], Netherlands Institute for Radio Astronomy (ASTRON), Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPC2E), Observatoire des Sciences de l'Univers en région Centre (OSUC), PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Max-Planck-Institut für Radioastronomie (MPIFR), NAOJ Chile Observatory, National Astronomical Observatory of Japan (NAOJ), Oxford Astrophysics, University of Oxford [Oxford], SKA South Africa, Ska South Africa, Department of Physics, George Washington University, George Washington University (GW), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Tata Institute for Fundamental Research (TIFR), University of Oxford-University of Oxford, Jodrell Bank Centre for Astrophysics (JBCA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Radboud University [Nijmegen], Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), University of Oxford, The George Washington University (GW), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), and Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)
Subjects: Physics, Giant Metrewave Radio Telescope, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, Astronomy, Astrophysics::High Energy Astrophysical Phenomena, LOFAR, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Low frequency, 01 natural sciences, Wind speed, Synchrotron, law.invention, 13. Climate action, Modulation, law, [SDU]Sciences of the Universe [physics], 0103 physical sciences, Maxima, Absorption (electromagnetic radiation), 010303 astronomy & astrophysics
Abstract: International audience; LS I +61 303 is a gamma-ray binary that exhibits an outburst at GHz frequencies each orbital cycle of 26.5 d and a superorbital modulation with a period of 4.6 yr. We have performed a detailed study of the low-frequency radio emission of LS I +61 303 by analyzing data from the Giant Metrewave Radio Telescope (GMRT) at 150, 235 and 610 MHz, and from the Low Frequency Array (LOFAR) at 150 MHz. We have detected the source for the first time at 150 MHz, which is also the first detection of a gamma-ray binary at such a low frequency. We have obtained the light-curves of the source at 150, 235 and 610 MHz, all of them showing orbital modulation. The light-curves at 235 and 610 MHz also show the existence of superorbital variability. A comparison with contemporaneous 15-GHz data shows remarkable differences with these light-curves. At 15 GHz we see clear outbursts, whereas at low frequencies we see variability with wide maxima. The light-curve at 235 MHz seems to be anticorrelated with the one at 610 MHz, implying a shift of about 0.5 orbital phases in the maxima. We model the shifts between the maxima at different frequencies as due to changes in the physical parameters of the emitting region assuming either free-free absorption or synchrotron self-absorption, obtaining expansion velocities for this region close to the stellar wind velocity with both mechanisms.
Published: 2017
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30. Standards Based Generation of a Virtual Factory Model

Author: Jain , Sanjay, Lechevalier , David, George Washington University ( GW ), Decision Sciences Department, Laboratoire Electronique, Informatique et Image ( Le2i ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), NIST 70NANB13H158, George Washington University 70NANB13H158, National Institute of Standards and Technology's Foreign Guest Researcher Program, United States Government, université de Bourgogne, LE2I, The George Washington University (GW), Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), and HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0209 industrial biotechnology, [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, 021103 operations research, 020901 industrial engineering & automation, 0211 other engineering and technologies, 02 engineering and technology, [INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation, Manufacturing systems, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Simulation
Abstract: International audience; Developing manufacturing simulation models usually requires experts with knowledge of multiple areas including manufacturing, modeling, and simulation software. The expertise requirements increase for virtual factory models that include representations of manufacturing at multiple resolution levels. This paper reports on an initial effort to automatically generate virtual factory models using manufacturing configuration data in standard formats as the primary input. The execution of the virtual factory generates time series data in standard formats mimicking a real factory. Steps are described for auto- generation of model components in a software environment primarily oriented for model development via a graphic user interface. Advantages and limitations of the approach and the software environment used are discussed. The paper concludes with a discussion of challenges in verification and validation of the virtual factory prototype model with its multiple hierarchical models and future directions.
Published: 2016

31. On the generalized KdV equation subject to a random perturbation

Author: Millet, Annie, Roudenko, Svetlana, Statistique, Analyse et Modélisation Multidisciplinaire (SAmos-Marin Mersenne) (SAMM), Université Paris 1 Panthéon-Sorbonne (UP1), Department of Mathematics [George Washington University] (GW), The George Washington University (GW), and Millet, Annie
Subjects: [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], [MATH.MATH-PR] Mathematics [math]/Probability [math.PR], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2016

32. Genome sequence of Aedes aegypti, a major arbovirus vector

Author: Sergio Verjovski-Almeida, James E. Galagan, Ryan C. Kennedy, Zhiyong Xi, Jason R. Miller, Eric Eisenstadt, Kyanne R. Reidenbach, Robert V. Bruggner, Yu-Hui Rogers, Hadi Quesneville, Doreen Werner, Owen White, Alexander S. Raikhel, Mario Stanke, J. Spencer Johnston, Diane D. Lovin, Evgenia V. Kriventseva, Ian T. Paulsen, Kathryn S. Campbell, Norman H. Lee, Ewan Birney, Karyn Megy, Hean Koo, David Kulp, Shelby L. Bidwell, Jingsong Zhu, Philip Montgomery, Paolo Amedeo, Yongmei Zhao, Chinnappa D. Kodira, Javier Costas, Michael C. Schatz, Steven P. Sinkins, Claire M. Fraser-Liggett, Martin Shumway, Kurt LaButti, Akio Mori, Brendan J. Loftus, Manfred Grabherr, Eric O. Stinson, Frank H. Collins, Zhijian Jake Tu, Monique R. Coy, Matt Crawford, Janice P. Vanzee, William M. Gelbart, Joshua Orvis, Peter Arensburger, Chunhong Mao, Evgeny M. Zdobnov, Saul A. Kravitz, Suely Lopes Gomes, David DeCaprio, David G. Hogenkamp, Daniel Lawson, Dennis L. Knudson, David W. Severson, George Dimopoulos, Marcelo B. Soares, Sinéad B. O'Leary, Peter W. Atkinson, David M. Jaffe, Becky deBruyn, Martin Hammond, Ana L. T. O. Nascimento, Jim Biedler, Stefan Wyder, Jose M. C. Tubio, Bruce W. Birren, Catherine A. Hill, Chad Nusbaum, Eduardo Lee, Song Li, Susan E. Brown, Jennifer R. Wortman, James R. Hogan, Hamza El-Dorry, Qi Zhao, Linda Hannick, Carlos Frederico Martins Menck, Vishvanath Nene, Jonathan Crabtree, Steven L. Salzberg, Michael H. Holmes, Maria de Fatima Bonaldo, Quinghu Ren, Mihaela Pertea, Charles Roth, Evan Mauceli, Karin Eiglmeier, Horacio Naveira, Brian J. Haas, Qiandong Zeng, Neil F. Lobo, Jennifer R. Schneider, The Institute for Genomic Research, The Institute for Genomic Research, Rockville, European Bioinformatics Institute [Hinxton] ( EMBL-EBI ), European Molecular Biology Laboratory [Hinxton], Broad Institute of MIT and Harvard ( BROAD INSTITUTE ), Broad Institute of MIT and Harvard, Virginia Polytechnic Institute and State University [Blacksburg], University College Dublin [Dublin] ( UCD ), Bloomberg School of Public Health, Johns Hopkins University ( JHU ) -Bloomberg School of Public Health, University of Geneva Medical School, Swiss Institute of Bioinformatics-University of Geneva Medical School, University of Notre Dame ( UND ), Harvard University [Cambridge], College of Agricultural Sciences Colorado State University, Colorado State University [Fort Collins] ( CSU ) -College of Agricultural Sciences, Northwestern University [Evanston], University of California [Riverside] ( UCR ), Department of Atmospheric, Oceanic and Planetary Physics [Oxford] ( AOPP ), University of Oxford [Oxford], Purdue University [West Lafayette], Centro Nacional de Genotipado Fundación Pública Galega de Medicina Xenómica Hospital Clínico Universitario de Santiago, Centro Nacional de Genotipado-Fundación Pública Galega de Medicina Xenómica-Hospital Clínico Universitario de Santiago, Institut Pasteur [Paris], Universidade de Sao Paulo Instituto de Quimica, Universidade de São Paulo ( USP ) -Instituto de Quimica, Texas A&M University [College Station], Joint Technology Center, University of Massachusetts [Amherst] ( UMass Amherst ), Universidade de Sao Paulo, Institute of Biomedical Sciences, Universidade de São Paulo ( USP ) -Institute of Biomedical Sciences, Instituto Butantan [São Paulo], Universidade da Coruña, University of Maryland [College Park], Institut Jacques Monod ( IJM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), University of California [Santa Cruz] ( UCSC ), Complexo Hospitalario Universitario de Santiago, Universität Göttingen, Georg-August-Universität Göttingen, George Washington University Medical Center, George Washington University ( GW ), The Institute for Genomic Research (TIGR), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], University College Dublin [Dublin] (UCD), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne (UNIL)-Université de Lausanne (UNIL)-University of Geneva Medical School, University of Notre Dame [Indiana] (UND), Colorado State University [Fort Collins] (CSU)-College of Agricultural Sciences, University of California [Riverside] (UCR), University of California, Department of Atmospheric, Oceanic and Planetary Physics [Oxford] (AOPP), Universidade de São Paulo (USP)-Instituto de Quimica, University of Massachusetts [Amherst] (UMass Amherst), University of Massachusetts System (UMASS), Universidade de São Paulo (USP)-Institute of Biomedical Sciences (ICB/USP), Universidade de São Paulo (USP), University of Maryland System, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), University of California [Santa Cruz] (UCSC), Georg-August-University [Göttingen], The George Washington University (GW), George Washington University (GW), Université de Lausanne = University of Lausanne (UNIL)-Université de Lausanne = University of Lausanne (UNIL)-University of Geneva Medical School, Harvard University, University of California [Riverside] (UC Riverside), University of California (UC), University of Oxford, Institut Pasteur [Paris] (IP), Universidade de São Paulo = University of São Paulo (USP)-Instituto de Quimica, Universidade de São Paulo = University of São Paulo (USP)-Institute of Biomedical Sciences (ICB/USP), Universidade de São Paulo = University of São Paulo (USP), University of California [Santa Cruz] (UC Santa Cruz), Georg-August-University = Georg-August-Universität Göttingen, Zdobnov, Evgeny, and Wyder, Stefan
Subjects: 0106 biological sciences, Male, Transcription, Genetic, Genome, Insect, transposons, receptors, Genes, Insect, Aedes/ genetics/metabolism, MESH: Genes, Insect, Yellow Fever/prevention & control/transmission, MESH: Base Sequence, 01 natural sciences, Dengue/prevention & control/transmission, MESH: Protein Structure, Tertiary, MESH: Arboviruses, MESH : Insect Vectors, MESH: Insect Proteins, MESH : Anopheles gambiae, MESH: Animals, MESH : Arboviruses, insects, MESH: Yellow Fever, superfamily, ddc:616, 0303 health sciences, Anopheles, MESH : Genes, Insect, 3. Good health, yellow-fever mosquito, anopheles-gambiae, drosophila-melanogaster, expression, evolution, organization, Drosophila melanogaster, MESH: DNA Transposable Elements, [ SDV.BBM.GTP ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Multigene Family, Public Health, MESH : Protein Structure, Tertiary, MESH: Sex Characteristics, Molecular Sequence Data, MESH : Multigene Family, MESH: Sex Determination (Genetics), MESH : Sex Determination (Genetics), Arbovirus, Article, 03 medical and health sciences, Species Specificity, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], MESH: Anopheles gambiae, Yellow Fever, MESH: Species Specificity, Humans, MESH: Humans, MESH: Molecular Sequence Data, fungi, MESH : Humans, MESH : Sex Characteristics, Membrane Transport Proteins, Sex Determination Processes, medicine.disease, Insect Vectors, Protein Structure, Tertiary, Sex Determination (Genetics), MESH: Multigene Family, MESH: Female, MESH : Sequence Analysis, DNA, MESH: Sequence Analysis, DNA, Drosophila melanogaster/genetics, MESH : Molecular Sequence Data, Odorant binding, Insect Proteins/genetics, Anopheles gambiae, MESH: Dengue, Genome, MESH: Membrane Transport Proteins, Dengue, MESH : Membrane Transport Proteins, Aedes, Insect Vectors/ genetics/metabolism, MESH : Drosophila melanogaster, MESH : Female, Membrane Transport Proteins/genetics, Genetics, MESH : Insect Proteins, Sex Characteristics, Multidisciplinary, MESH: Synteny, MESH: Aedes, MESH : Genome, Insect, MESH : DNA Transposable Elements, Insect Proteins, Female, Orthologous Gene, MESH : Male, MESH : Dengue, Aedes aegypti, MESH: Insect Vectors, Biology, 010603 evolutionary biology, Synteny, MESH: Drosophila melanogaster, Protein Structure, Tertiary/genetics, MESH : Yellow Fever, parasitic diseases, medicine, MESH : Species Specificity, Animals, 030304 developmental biology, MESH : Aedes, Base Sequence, MESH: Genome, Insect, MESH: Transcription, Genetic, MESH : Synteny, MESH : Transcription, Genetic, Sequence Analysis, DNA, biology.organism_classification, MESH: Male, DNA Transposable Elements, MESH : Base Sequence, MESH : Animals, Arboviruses, Anopheles gambiae/genetics/metabolism
Abstract: We present a draft sequence of the genome of Aedes aegypti , the primary vector for yellow fever and dengue fever, which at ∼1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae . Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of ∼4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster . Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of ∼2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.
Published: 2016
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33. Low-radio-frequency eclipses of the redback pulsar J2215+5135 observed in the image plane with LOFAR

Author: Michael Kramer, S. ter Veen, Jean-Mathias Grießmeier, J. van Leeuwen, Tim Hassall, P.G. Jonker, Rudy Wijnands, M. Pietka, Ralph A. M. J. Wijers, Adam Stewart, L. H. A. Scheers, John D. Swinbank, Rob Fender, M. Kuniyoshi, Ben Stappers, M. Serylak, Heino Falcke, J. W. Broderick, Jochen Eislöffel, D. Carbone, Martin Bell, Michael W. Wise, Tim D. Staley, Sera Markoff, Antonia Rowlinson, Y. Cendes, A. J. van der Horst, Rene P. Breton, Jason W. T. Hessels, Gijs Molenaar, Stephane Corbel, Philippe Zarka, Casey J. Law, High Energy Astrophys. & Astropart. Phys (API, FNWI), Faculty of Science, University of Southampton, Jodrell Bank Centre for Astrophysics, University of Manchester [Manchester], Laboratory for Atmospheric and Space Physics [Boulder] (LASP), University of Colorado [Boulder], CSIRO Astronomy and Space Science, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Netherlands Institute for Radio Astronomy (ASTRON), Oxford Astrophysics, University of Oxford [Oxford], The George Washington University (GW), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Unité Scientifique de la Station de Nançay (USN), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO), Thüringer Landessternwarte Tautenburg (TLS), Radboud university [Nijmegen], Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPC2E), Observatoire des Sciences de l'Univers en région Centre (OSUC), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National d’Études Spatiales [Paris] (CNES), Institute for Mathematics, Astrophysics and Particle Physics (IMAPP), Max-Planck-Institut für Radioastronomie (MPIFR), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ANR-10-LABX-0023,UnivEarthS,Earth - Planets - Universe: observation, modeling, transfer(2010), ANR-11-IDEX-0005,USPC,Université Sorbonne Paris Cité(2011), European Project: 267697,EC:FP7:ERC,ERC-2010-AdG_20100224,4PI-SKY(2011), European Project: 247295,EC:FP7:ERC,ERC-2009-AdG,AARTFAAC(2010), European Project: 337062,EC:FP7:ERC,ERC-2013-StG,DRAGNET(2014), University of Oxford, Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Radboud University [Nijmegen], Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Database Architectures, George Washington University (GW), Université d'Orléans (UO)-Observatoire des Sciences de l'Univers en région Centre (OSUC), PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), ANR-10-LABX-0023,Labex UnivEarthS, and ANR-11-IDEX-0005-02/10-LABX-0023,UnivEarthS,Earth - Planets - Universe: observation, modeling, transfer(2011)
Subjects: media_common.quotation_subject, Astronomy, Astrophysics::High Energy Astrophysical Phenomena, general [Pulsars], FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, 01 natural sciences, Radio telescope, Pulsar, Millisecond pulsar, pulsars: general, 0103 physical sciences, individual: PSR J2215+5135 [Pulsars], Keywords: binaries: eclipsing, pulsars: individual: PSR J2215+5135, Astrophysics::Solar and Stellar Astrophysics, radio continuum: stars, 010303 astronomy & astrophysics, binaries: eclipsing, media_common, Eclipse, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, 010308 nuclear & particles physics, eclipsing [Binaries], Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, LOFAR, Interferometry, Space and Planetary Science, Sky, [SDU]Sciences of the Universe [physics], ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, stars [Radio continuum], Radio frequency, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The eclipses of certain types of binary millisecond pulsars (i.e. `black widows' and `redbacks') are often studied using high-time-resolution, `beamformed' radio observations. However, they may also be detected in images generated from interferometric data. As part of a larger imaging project to characterize the variable and transient sky at radio frequencies, 9 pages, 4 figures, 4 tables, accepted for publication in MNRAS
Published: 2016
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34. Soliton dynamics of the gKdV equation subject to a random perturbation

Author: Millet, Annie, Roudenko, Svetlana, Statistique, Analyse et Modélisation Multidisciplinaire (SAmos-Marin Mersenne) (SAMM), Université Paris 1 Panthéon-Sorbonne (UP1), Department of Mathematics [George Washington University] (GW), The George Washington University (GW), and Millet, Annie
Subjects: [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], [MATH.MATH-PR] Mathematics [math]/Probability [math.PR], Nonlinear Sciences::Exactly Solvable and Integrable Systems, Mathematics::Analysis of PDEs, solitons, generalized KdV equation, Nonlinear Sciences::Pattern Formation and Solitons, additive noise
Abstract: International audience; We study random perturbations of solitary solutions to generalized KdV equation. The amplitude of the perturbation issmall and the exit time of a neighborhood of the modulated soliton is investigated. This is a joint work with Svetlana Roudenko.
Published: 2016

35. From fossils to mind

Author: de Sousa, A., Beaudet, A., Calvey, T., Bardo, A., Benoit, J., Charvet, C., Dehay, C., Gómez-Robles, A., Gunz, P., https://orcid.org/0000-0002-2350-4450, Heuer, K., van den Heuvel, M., Hurst, S., Lauters, P., Reed, D., Salagnon, M., Sherwood, C., Ströckens, F., Tawane, M., Todorov, O., Toro, R., Wei, Y., de Sousa, Alexandra A [0000-0003-2379-3894], Beaudet, Amélie [0000-0002-9363-5966], Calvey, Tanya [0000-0002-7540-2130], Bardo, Ameline [0000-0003-1840-6423], Gómez-Robles, Aida [0000-0002-8719-2660], Gunz, Philipp [0000-0002-2350-4450], Heuer, Katja [0000-0002-7237-0196], van den Heuvel, Martijn P [0000-0003-1570-1195], Hurst, Shawn [0000-0002-1458-759X], Lauters, Pascaline [0000-0003-3664-3182], Sherwood, Chet C [0000-0001-6711-449X], Todorov, Orlin S [0000-0002-0295-7557], Apollo - University of Cambridge Repository, Bath Spa University, Laboratoire de paléontologie, évolution, paléoécosystèmes, paléoprimatologie (PALEVOPRIM ), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), University of Cambridge [UK] (CAM), University of Cape Town, Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), University of Kent [Canterbury], University of the Witwatersrand [Johannesburg] (WITS), Auburn University (AU), Institut cellule souche et cerveau / Stem Cell and Brain Research Institute (SBRI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University College of London [London] (UCL), Max Planck Institute for Evolutionary Anthropology [Leipzig], Max-Planck-Gesellschaft, Neuroanatomie Appliquée et Théorique / Applied and Theoretical Neuroanatomy (NAAT), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Vrije Universiteit Amsterdam [Amsterdam] (VU), Indiana University - Purdue University Indianapolis (IUPUI), Indiana University System, Institut Royal des Sciences Naturelles de Belgique (IRSNB), University of Texas at Austin [Austin], Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), The George Washington University (GW), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], Ditsong National Museum of Natural History [Pretoria, South Africa] (DNMNH), Macquarie University [Sydney], Beijing University of Posts and Telecommunications (BUPT), A.Ba. was funded by the Agence Nationale de la Recherche (grant number: ANR-20-CE27-0009-01). A.Be. was funded by the National Research Foundation of South Africa (Research Development Grants for Y-Rated Researchers (grant number 129336) and the South Africa/France (PROTEA) Joint Research Programme (grant number 129923). C.C.S. was funded by NSF (EF-2021785, DRL-2219759) and NIH (NS092988, AG067419, HG011641). C.J.C. was funded by NIGMS COBRE (grant number 5P20GM103653). J.B. was funded by the NRF African Origins Platform. K.H. and R.T. were supported by the French Agence Nationale de la Recherche, projects NeuroWebLab (ANR-19-DATA-0025) and DMOBE (ANR-21-CE45-0016). K.H. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No101033485 (Individual Fellowship). O.S.T was funded by a Discovery Project Award (project number: DP210101324) funded by the Australian Government. P.G. was funded by the Max Planck Society (grant number M.IF.A.XXXX8103)., ANR-20-CE27-0009,PaleoBRAIN,Ressusciter le cerveau d'Homo erectus et des Néandertaliens(2020), ANR-19-DATA-0025,NeuroWebLab,Un laboratoire de neuroscience collectif: Au delà de FAIR(2019), and ANR-21-CE45-0016,DMOBE,Méchanique dévelopemental de l'évolution du cerveau(2021)
Subjects: [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Archaeology, Fossils, Brain, Artifacts, Phylogeny, [SHS]Humanities and Social Sciences
Abstract: International audience; Fossil endocasts record features of brains from the past: size, shape, vasculature, and gyrification. These data, alongside experimental and comparative evidence, are needed to resolve questions about brain energetics, cognitive specializations, and developmental plasticity. Through the application of interdisciplinary techniques to the fossil record, paleoneurology has been leading major innovations. Neuroimaging is shedding light on fossil brain organization and behaviors. Inferences about the development and physiology of the brains of extinct species can be experimentally investigated through brain organoids and transgenic models based on ancient DNA. Phylogenetic comparative methods integrate data across species and associate genotypes to phenotypes, and brains to behaviors. Meanwhile, fossil and archeological discoveries continuously contribute new knowledge. Through cooperation, the scientific community can accelerate knowledge acquisition. Sharing digitized museum collections improves the availability of rare fossils and artifacts. Comparative neuroanatomical data are available through online databases, along with tools for their measurement and analysis. In the context of these advances, the paleoneurological record provides ample opportunity for future research. Biomedical and ecological sciences can benefit from paleoneurology’s approach to understanding the mind as well as its novel research pipelines that establish connections between neuroanatomy, genes and behavior.
Published: 2023
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36. LOFAR MSSS: detection of a low-frequency radio transient in 400 h of monitoring of the North Celestial Pole

Author: Rebecca McFadden, Martin Bell, Sera Markoff, G. Kokotanekov, R. J. van Weeren, D. McKay-Bukowski, James M. Anderson, Jason W. T. Hessels, Peter G. Jonker, Ralph A. M. J. Wijers, H. Munk, Casey J. Law, Frank Breitling, B. Scheers, Marcus Brüggen, M. C. Toribio, A. Horneffer, George Heald, M. A. Garrett, Aris Karastergiou, Luke Pratley, Rudy Wijnands, Y. Cendes, F. de Gasperin, A. Alexov, Michael W. Wise, Gianni Bernardi, Jörg R. Hörandel, B. Ciardi, M. Kuniyoshi, James Miller-Jones, J. van Leeuwen, T. Munoz-Darias, Aleksandar Shulevski, John McKean, J.-M. Grießmeier, John D. Swinbank, Jochen Eislöffel, P. Maat, Cyril Tasse, Wilfred Frieswijk, M. J. Norden, J. W. Broderick, A. G. Polatidis, Arthur Corstanje, T E Hassall, Heino Falcke, Harvey Butcher, E. de Geus, V. I. Kondratiev, E. Juette, Anna M. M. Scaife, M. Pandey-Pommier, Benjamin Stappers, H. Paas, A. W. Gunst, I. M. Avruch, Volker Heesen, D. Carbone, Mark J. Bentum, Antonia Rowlinson, Annalisa Bonafede, Rob Fender, J. Sluman, E. Rol, Matthias Steinmetz, Chiara Ferrari, Gijs Molenaar, S. Duscha, G. Kuper, D. D. Mulcahy, Sarod Yatawatta, Philip Best, M. Pietka, H. J. A. Röttgering, Satyendra Thoudam, A. O. Clarke, Adam Stewart, M. P. van Haarlem, Charlotte Sobey, M. Iacobelli, Olaf Wucknitz, Matthias Hoeft, Emanuela Orrú, M. Loose, Ph. Zarka, Adam Deller, Martin J. Hardcastle, Tim D. Staley, Ashish Asgekar, J. Moldon, Dominik J. Schwarz, A. J. van der Horst, Christian Vocks, Rene P. Breton, John Conway, Stephane Corbel, R. C. Vermeulen, Stefan J. Wijnholds, S. van Velzen, T. L. Grobler, Oleg Smirnov, Astronomy, Laboratory for Atmospheric and Space Physics [Boulder] (LASP), University of Colorado [Boulder], University of Southampton, Jodrell Bank Centre for Astrophysics, University of Manchester [Manchester], School of Physics and Astronomy [Southampton], Netherlands Institute for Radio Astronomy (ASTRON), Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Oxford Astrophysics, University of Oxford [Oxford], Rhodes University, Grahamstown, CSIRO Astronomy and Space Science, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Jacobs University [Bremen], Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Unité Scientifique de la Station de Nançay (USN), Université d'Orléans (UO)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Universität Hamburg (UHH), Thüringer Landessternwarte Tautenburg (TLS), Radboud university [Nijmegen], Département de Géologie, Université de Montréal [Montréal], Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPC2E), Observatoire des Sciences de l'Univers en région Centre (OSUC), PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), University of Hertfordshire [Hatfield] (UH), Max-Planck-Institut für Radioastronomie (MPIFR), Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Institute for Mathematics, Astrophysics and Particle Physics (IMAPP), Curtin University [Perth], Planning and Transport Research Centre (PATREC), Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Victoria University of Wellington, Kapteyn Astronomical Institute [Groningen], University of Groningen [Groningen], SKA South Africa, Ska South Africa, Galaxies, Etoiles, Physique, Instrumentation (GEPI), PSL Research University (PSL)-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Department of Mathematics, The George Washington University, Washington State University (WSU), Harvard-Smithsonian Center for Astrophysics (CfA), Harvard University [Cambridge]-Smithsonian Institution, Anton Pannekoek Institute for Astronomy, Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institute for Mathematics Applied to Geoscience, National Center for Atmospheric Research [Boulder] (NCAR), SRON Netherlands Institute for Space Research (SRON), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), University of Edinburgh, Leibniz-Institut für Astrophysik Potsdam (AIP), Max Planck Institute for Astrophysics, Max-Planck-Gesellschaft, Onsala Space Observatory, Dept. of Radio and Space Science, Chalmers University of Technology, Chalmers University of Technology [Göteborg], Ruhr-Universität Bochum [Bochum], University of Oulu, The Netherlands Institute for Radio Astronomy (ASTRON), 7990-AA Dwingeloo, Netherlands, Departament d'Astronomia i Meteorologia [Barcelona], Institut de Ciènces del Cosmos (ICC), Universitat de Barcelona (UB)-Universitat de Barcelona (UB), Center for Information Technology CIT, Université de Groningen, Interactions Son Musique Mouvement, Sciences et Technologies de la Musique et du Son (STMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), Rhodes University, Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH / Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures (DSMZ), Finca El Encin, Instituto Madrileño de Investigación y Desarrollo Rural, Agrario y Alimentario (IMIDRA), Argelander-Institut für Astronomie (AlfA), Rheinische Friedrich-Wilhelms-Universität Bonn, High Energy Astrophys. & Astropart. Phys (API, FNWI), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO), Université de Montréal (UdeM), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National d’Études Spatiales [Paris] (CNES), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Department of Mathematics [George Washington University] (GW), The George Washington University (GW), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Universitat de Barcelona (UB), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), University of Oxford, Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Radboud University [Nijmegen], Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Universiteit Leiden, École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Harvard University-Smithsonian Institution, Stewart, A.J., Fender, R.P., Broderick, J.W., Hassall, T.E., Muñoz-Darias, T., Rowlinson, A., Swinbank, J.D., Staley, T.D., Molenaar, G.J., Scheers, B., Grobler, T.L., Pietka, M., Heald, G., McKean, J.P., Bell, M.E., Bonafede, A., Breton, R.P., Carbone, D., Cendes, Y., Clarke, A.O., Corbel, S., De Gasperin, F., Eislöffel, J., Falcke, H., Ferrari, C., Grießmeier, J.-M., Hardcastle, M.J., Heesen, V., Hessels, J.W.T., Horneffer, A., Iacobelli, M., Jonker, P., Karastergiou, A., Kokotanekov, G., Kondratiev, V.I., Kuniyoshi, M., Law, C.J., van Leeuwen, J., Markoff, S., Miller-Jones, J.C.A., Mulcahy, D., Orru, E., Pandey-Pommier, M., Pratley, L., Rol, E., Röttgering, H.J.A., Scaife, A.M.M., Shulevski, A., Sobey, C.A., Stappers, B.W., Tasse, C., van der Horst, A.J., van Velzen, S., van Weeren, R.J., Wijers, R.A.M.J., Wijnands, R., Wise, M., Zarka, P., Alexov, A., Anderson, J., Asgekar, A., Avruch, I.M., Bentum, M.J., Bernardi, G., Best, P., Breitling, F., Brüggen, M., Butcher, H.R., Ciardi, B., Conway, J.E., Corstanje, A., de Geus, E., Deller, A., Duscha, S., Frieswijk, W., Garrett, M.A., Gunst, A.W., Van Haarlem, M.P., Hoeft, M., Hörandel, J., Juette, E., Kuper, G., Loose, M., Maat, P., McFadden, R., McKay-Bukowski, D., Moldon, J., Munk, H., Norden, M.J., Paas, H., Polatidis, A.G., Schwarz, D., Sluman, J., Smirnov, O., Steinmetz, M., Thoudam, S., Toribio, M.C., Vermeulen, R., Vocks, C., Wijnholds, S.J., Wucknitz, O., Yatawatta, S., ITA, GBR, FRA, DEU, and NLD
Subjects: Astronomy, media_common.quotation_subject, interferometers [instrumentation], radio continuum: general, FOS: Physical sciences, techniques: image processing, 02 engineering and technology, Astrophysics, Low frequency, 01 natural sciences, Instrumentation: interferometer, Celestial pole, 0103 physical sciences, IR-102656, 0202 electrical engineering, electronic engineering, information engineering, instrumentation: interferometers, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, media_common, EWI-27481, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, image processing [techniques], METIS-320906, 020206 networking & telecommunications, Astronomy and Astrophysics, LOFAR, Limiting, Astronomy and Astrophysic, instrumentation: interferometers – techniques: image processing – radio continuum: general, radio, continuum: general, Observation duration, Space and Planetary Science, Sky, [SDU]Sciences of the Universe [physics], ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, general [radio continuum], Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: We present the results of a four-month campaign searching for low-frequency radio transients near the North Celestial Pole with the Low-Frequency Array (LOFAR), as part of the Multifrequency Snapshot Sky Survey (MSSS). The data were recorded between 2011 December and 2012 April and comprised 2149 11-minute snapshots, each covering 175 deg^2. We have found one convincing candidate astrophysical transient, with a duration of a few minutes and a flux density at 60 MHz of 15-25 Jy. The transient does not repeat and has no obvious optical or high-energy counterpart, as a result of which its nature is unclear. The detection of this event implies a transient rate at 60 MHz of 3.9 (+14.7, -3.7) x 10^-4 day^-1 deg^-2, and a transient surface density of 1.5 x 10^-5 deg^-2, at a 7.9-Jy limiting flux density and ~10-minute time-scale. The campaign data were also searched for transients at a range of other time-scales, from 0.5 to 297 min, which allowed us to place a range of limits on transient rates at 60 MHz as a function of observation duration., 23 pages, 16 figures, 5 tables, accepted for publication in MNRAS
Published: 2016
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37. Turnover rates in microorganisms by laser ablation electrospray ionization mass spectrometry and pulse-chase analysis

Author: Denis Falconet, Sylwia A. Stopka, Tarek R. Mansour, Akos Vertes, Eric Maréchal, Bindesh Shrestha, Department of Chemistry, The George Washington University (GW)-W. M. Keck Institute of Proteomics Technology and Applications, Physiologie cellulaire et végétale (LPCV), Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Chemical Sciences, Geosciences and Biosciences Division under Award Number DE-FG02-01ER15129, ANR-12-BIME-0005,DiaDomOil,Domestication des diatomées pour la production de biocarburants(2012), George Washington University (GW)-W. M. Keck Institute of Proteomics Technology and Applications, Laboratoire de physiologie cellulaire végétale (LPCV), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Spectrometry, Mass, Electrospray Ionization, Algae, Laser ablation electrospray ionization, Metabolite, [SDV]Life Sciences [q-bio], Chlamydomonas reinhardtii, Mass spectrometry, Photosynthesis, Biochemistry, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Metabolites, Metabolic turnover rates, Microalgae, Environmental Chemistry, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Spectroscopy, Chromatography, biology, Chemistry, Lasers, Lipid metabolism, Metabolism, biology.organism_classification, Cell cultures, Lipids, Techniques, 030104 developmental biology, Isotope Labeling, Chlorophyll, Peptides
Abstract: International audience; Biochemical processes rely on elaborate networks containing thousands of compounds participating in thousands of reaction. Rapid turnover of diverse metabolites and lipids in an organism is an essential part of homeostasis. It affects energy production and storage, two important processes utilized in bioengineering. Conventional approaches to simultaneously quantify a large number of turnover rates in biological systems are currently not feasible. Here we show that pulse-chase analysis followed by laser ablation electrospray ionization mass spectrometry (LAESI-MS) enable the simultaneous and rapid determination of metabolic turnover rates. The incorporation of ion mobility separation (IMS) allowed an additional dimension of analysis, i.e., the detection and identification of isotopologs based on their collision cross sections. We demonstrated these capabilities by determining metabolite, lipid, and peptide turnover in the photosynthetic green algae, Chlamydomonas reinhardtii, in the presence of 15N-labeled ammonium chloride as the main nitrogen source. Following the reversal of isotope patterns in the chase phase by LAESI-IMS-MS revealed the turnover rates and half-lives for biochemical species with a wide range of natural concentrations, e.g., chlorophyll metabolites, lipids, and peptides. For example, the half-lives of lyso-DGTS(16:0) and DGTS(18:3/16:0), t1/2 = 43.6 ± 4.5 h and 47.6 ± 2.2 h, respectively, provided insight into lipid synthesis and degradation in this organism. Within the same experiment, half-lives for chlorophyll a, t1/2 = 24.1 ± 2.2 h, and a 2.8 kDa peptide, t1/2 = 10.4 ± 3.6 h, were also determined.
Published: 2016
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38. Organic Compounds on the Nucleus of Comet 67/Churyumov-Gerasimenko as Revealed by COSAC Mass Spectrometry

Author: Goesmann , Fred, Rosenbauer , Helmut, Bredehoeft , Jan Hendrik, Cabane , Michel, Ehrenfreund , Pascale, Gauthier , Thomas, Giri , Chaitanya, Krueger , Harald, Le Roy , Léna, Mc Dermott , Alexandra, McKenna Lawlor , Susan, Meierhenrich , U., Munoz Caro , G., Raulin , François, Roll , R., Steele , A., Steininger , H., Sternberg , R., Szopa , Cyril, Thiemann , W., Ulamec , S., Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, Institute for Applied and Physical Chemistry [Bremen] (IAPC), University of Bremen, PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Leiden Observatory [Leiden], Universiteit Leiden, Space Policy Institute [Washington], The George Washington University (GW), NASA Goddard Space Flight Center (GSFC), Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Center for Space and Habitability (CSH), University of Bern, University of Houston [Clear Lake], Space Technology Ireland Limited, Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Geophysical Laboratory [Carnegie Institution], Carnegie Institution for Science, German Aerospace Center (DLR), USRA Houston, Max Planck Institute for Solar System Research (MPS), Universiteit Leiden [Leiden], Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Carnegie Institution for Science [Washington], Cardon, Catherine, Max Planck Institute for Solar System Research ( MPS ), Institute for Applied and Physical Chemistry [Bremen] ( IAPC ), IMPEC - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales ( LATMOS ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), George Washington University ( GW ), NASA Goddard Space Flight Center ( GSFC ), Institut de Chimie de Nice ( ICN ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Center for Space and Habitability ( CSH ), University of Houston-Clear Lake, Centro de Astrobiologia [Madrid] ( CAB ), Instituto Nacional de Técnica Aeroespacial ( INTA ) -Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Laboratoire inter-universitaire des systèmes atmosphèriques ( LISA ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ) -Centre National de la Recherche Scientifique ( CNRS ), German Aerospace Center ( DLR ), George Washington University (GW), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), and Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], [SDU.ASTR.EP] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], [ SDU.ASTR.EP ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP]
Abstract: International audience; The evolved gas analyzer COmetary SAmplingand Composition experiment (COSAC) aboardthe Philae Lander of ESA’s Rosetta mission was designedto make unique in situ chemical analyses ofnucleus material from comet 67P/Churyumov-Gerasimenko, with an emphasis on organic molecules.Twenty-five minutes after Philae’s initial touchdown,the COSAC mass spectrometer took a spectrum insniffing mode, which displayed an interesting suite oforganic compounds. The sampled material is likely tohave originated from the dust cloud produced by Philae’sfirst contact with the ground. Analysis of themass spectrum shows 16 compounds, among them sixdistinct organic homologous series: alcohols, carbonyls,amines, nitriles, amides and isocyanates. Nearlyall the molecules inferred from our data are potentialprecursors, products, adducts or by-products of eachother that can be formed either by surface reactions orby thermal and/or radiation processing of icy surfaces.A relatively abundant nitrogen source, such as NH3, isrequired to form the suite of N-bearing species. Severalorganic compounds have not been identified in cometsbefore or only upper limits have been derived. Overallthe identified compounds provide indications of severalpossible links between interstellar chemistry, cometaryorganic chemistry and terrestrial prebiotic chemistry.These unique COSAC measurements from a cometarysurface provide an unprecedented glimpse intothe early origins of our solar system, 4.6 billion yearsago.
Published: 2015

39. Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism

Author: Tewarit Sarachana, Rachel M. Sherrard, Valerie W. Hu, Kristen M. Kocher, Department of Biochemistry and Molecular Medicine, The George Washington University (GW), Department of Clinical Chemistry, Chulalongkorn University [Bangkok], Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), George Washington University (GW), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Administateur, HAL Sorbonne Université
Subjects: Transcriptional targets, Autism, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Postmortem brain tissues, Human Males, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, Biology, Developmental Neuroscience, Sex differences, medicine, Aromatase, Molecular Biology, Orphan receptor, Mouse brain, Research, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Human brain, medicine.disease, RORA expression, Human genetics, Sexual dimorphism, Psychiatry and Mental health, medicine.anatomical_structure, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Autism spectrum disorder, biology.protein, Neuroscience, Developmental Biology
Abstract: Background Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by significant impairment in reciprocal social interactions and communication coupled with stereotyped, repetitive behaviors and restricted interests. Although genomic and functional studies are beginning to reveal some of the genetic complexity and underlying pathobiology of ASD, the consistently reported male bias of ASD remains an enigma. We have recently proposed that retinoic acid-related orphan receptor alpha (RORA), which is reduced in the brain and lymphoblastoid cell lines of multiple cohorts of individuals with ASD and oppositely regulated by male and female hormones, might contribute to the sex bias in autism by differentially regulating target genes, including CYP19A1 (aromatase), in a sex-dependent manner that can also lead to elevated testosterone levels, a proposed risk factor for autism. Methods In this study, we examine sex differences in RORA and aromatase protein levels in cortical tissues of unaffected and affected males and females by re-analyzing pre-existing confocal immunofluorescence data from our laboratory. We further investigated the expression of RORA and its correlation with several of its validated transcriptional targets in the orbital frontal cortex and cerebellum as a function of development using RNAseq data from the BrainSpan Atlas of the Developing Human Brain. In a pilot study, we also analyzed the expression of Rora and the same transcriptional targets in the cortex and cerebellum of adult wild-type male and female C57BL/6 mice. Results Our findings suggest that Rora/RORA and several of its transcriptional targets may exhibit sexually dimorphic expression in certain regions of the brain of both mice and humans. Interestingly, the correlation coefficients between Rora expression and that of its targets are much higher in the cortex of male mice relative to that of female mice. A strong positive correlation between the levels of RORA and aromatase proteins is also seen in the cortex of control human males and females as well as ASD males, but not ASD females. Conclusions Based on these studies, we suggest that disruption of Rora/RORA expression may have a greater impact on males, since sex differences in the correlation of RORA and target gene expression indicate that RORA-deficient males may experience greater dysregulation of genes relevant to ASD in certain brain regions during development. Electronic supplementary material The online version of this article (doi:10.1186/2040-2392-6-7) contains supplementary material, which is available to authorized users.
Published: 2015
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40. A systematic review of annotation for surgical process model analysis in minimally invasive surgery based on video

Author: Krystel Nyangoh Timoh, Arnaud Huaulme, Kevin Cleary, Myra A. Zaheer, Vincent Lavoué, Dan Donoho, Pierre Jannin, CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Children's National Hospital [Washington, DC, USA] (CNHW), and The George Washington University (GW)
Subjects: Surgical video, Surgical process model, Surgical data science, Ontology, Minimally invasive surgery, Annotation, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Surgery, Article
Abstract: International audience; BackgroundAnnotated data are foundational to applications of supervised machine learning. However, there seems to be a lack of common language used in the field of surgical data science.The aim of this study is to review the process of annotation and semantics used in the creation of SPM for minimally invasive surgery videos.MethodsFor this systematic review, we reviewed articles indexed in the MEDLINE database from January 2000 until March 2022. We selected articles using surgical video annotations to describe a surgical process model in the field of minimally invasive surgery. We excluded studies focusing on instrument detection or recognition of anatomical areas only. The risk of bias was evaluated with the Newcastle Ottawa Quality assessment tool. Data from the studies were visually presented in table using the SPIDER tool.ResultsOf the 2806 articles identified, 34 were selected for review. Twenty-two were in the field of digestive surgery, six in ophthalmologic surgery only, one in neurosurgery, three in gynecologic surgery, and two in mixed fields. Thirty-one studies (88.2%) were dedicated to phase, step, or action recognition and mainly relied on a very simple formalization (29, 85.2%). Clinical information in the datasets was lacking for studies using available public datasets. The process of annotation for surgical process model was lacking and poorly described, and description of the surgical procedures was highly variable between studies.ConclusionSurgical video annotation lacks a rigorous and reproducible framework. This leads to difficulties in sharing videos between institutions and hospitals because of the different languages used. There is a need to develop and use common ontology to improve libraries of annotated surgical videos.
Published: 2023
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41. Organic compounds on comet 67P/Churyumov-Gerasimenko revealed by COSAC mass spectrometry

Author: Michel Cabane, Pascale Ehrenfreund, A. J. MacDermott, Thomas Gautier, Uwe J. Meierhenrich, Wolfram Thiemann, Harald Steininger, Guillermo M. Muñoz Caro, H. Rosenbauer, Cyril Szopa, Chaitanya Giri, Robert Sternberg, Andrew Steele, Stephan Ulamec, Fred Goesmann, Jan Hendrik Bredehöft, Léna Le Roy, Reinhard Roll, Susan McKenna-Lawlor, François Raulin, Harald Krüger, Max Planck Institute for Solar System Research ( MPS ), Institute for Applied and Physical Chemistry [Bremen] ( IAPC ), University of Bremen, IMPEC - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales ( LATMOS ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Space Policy Institute [Washington], George Washington University ( GW ), NASA Goddard Space Flight Center ( GSFC ), Institut de Chimie de Nice ( ICN ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Center for Space and Habitability ( CSH ), University of Bern, University of Houston-Clear Lake, Space Technology Ireland Limited, Centro de Astrobiologia [Madrid] ( CAB ), Instituto Nacional de Técnica Aeroespacial ( INTA ) -Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Laboratoire inter-universitaire des systèmes atmosphèriques ( LISA ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ) -Centre National de la Recherche Scientifique ( CNRS ), Geophysical Laboratory [Carnegie Institution], Carnegie Institution for Science [Washington], German Aerospace Center ( DLR ), Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, Institute for Applied and Physical Chemistry [Bremen] (IAPC), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), The George Washington University (GW), NASA Goddard Space Flight Center (GSFC), Institut de Chimie de Nice (ICN), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Center for Space and Habitability (CSH), University of Houston [Clear Lake], Centro de Astrobiologia [Madrid] (CAB), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), German Aerospace Center (DLR), George Washington University (GW), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Universiteit Leiden, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), and Carnegie Institution for Science
Subjects: Solar System, 010504 meteorology & atmospheric sciences, Comet, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Mass spectrometry, 01 natural sciences, Astrobiology, chemistry.chemical_compound, comet, 0103 physical sciences, Acetone, 010303 astronomy & astrophysics, Refractory (planetary science), mass spectrometry, 0105 earth and related environmental sciences, 67P, Multidisciplinary, COSAC, Chemistry, Propionaldehyde, Philae, [ SDU.ASTR.EP ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Gas analyzer, 13. Climate action, In situ analysis, organic compounds
Abstract: International audience; Comets harbor the most pristine material in our solar system in the form of ice, dust, silicates, and refractory organic material with some interstellar heritage. The evolved gas analyzer Cometary Sampling and Composition (COSAC) experiment aboard Rosetta’s Philae lander was designed for in situ analysis of organic molecules on comet 67P/Churyumov-Gerasimenko. Twenty-five minutes after Philae’s initial comet touchdown, the COSAC mass spectrometer took a spectrum in sniffing mode, which displayed a suite of 16 organic compounds, including many nitrogen-bearing species but no sulfur-bearing species, and four compounds—methyl isocyanate, acetone, propionaldehyde, and acetamide—that had not previously been reported in comets.
Published: 2015
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42. COSAC prepares for sampling and in situ analysis of cometary matter from comet 67P/Churyumov-Gerasimenko

Author: Uwe J. Meierhenrich, R. Roll, Fred Goesmann, François Raulin, S. M. P. McKenna-Lawlor, Pascale Ehrenfreund, Jan Hendrik Bredehöft, Stephan Ulamec, Michel Cabane, G. M. Muñoz Caro, Wolfram Thiemann, A. J. MacDermott, Cyril Szopa, Robert Sternberg, Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Institute for Applied and Physical Chemistry [Bremen] (IAPC), University of Bremen, PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Leiden Observatory [Leiden], Universiteit Leiden, Space Policy Institute [Washington], The George Washington University (GW), University of Houston [Clear Lake], Space Technology Ireland Limited, Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), German Aerospace Center (DLR), Max Planck Institute for Solar System Research (MPS), Universiteit Leiden [Leiden], Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), IMPEC - LATMOS, George Washington University (GW), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), and Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC)
Subjects: Physics, Solar System, COSAC, [PHYS.ASTR.EP]Physics [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Comet, Rendezvous, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Astronomy, Astronomy and Astrophysics, comet 67P/Churyumov-Gerasimenko, Astrobiology, Nutzerzentrum für Weltraumexperimente (MUSC), 13. Climate action, Space and Planetary Science, Gas analyser, Comet nucleus, In situ analysis, Rosetta, Organic compounds, Comets, Formation and evolution of the Solar System, Solar system
Abstract: International audience; The comet rendezvous mission Rosetta will be the first mission to encounter and land on a comet nucleus. After a 10-year journey Rosetta is set for rendezvous with Comet 67P/Churyumov-Gerasimenko in summer 2014. The mission goal is: to study the origin of comets; the relationship between cometary and interstellar material and its implications for the origin of the solar system. The Rosetta spacecraft with an overall mass of about 3000 kg was launched in March 2004 and brought into cometary orbit towards comet 67P/Churyumov-Gerasimenko with 4 gravity assist maneuvers. On its way Rosetta passed and observed two asteroids, (2867) Šteins in 2008 and (21) Lutetia in 2010, respectively. In June 2011 Rosetta entered into hibernation and woke up - as planned - on January 20, 2014. In November 2014 Rosetta's Philae lander and 10 science instruments will be deployed onto the surface of comet 67P/Churyumov-Gerasimenko. This will be followed by the first ever in situ investigation of a comet nucleus. Onboard Philae is the COmetary SAmpling and Composition experiment (COSAC), one of two evolved gas analysers that will investigate organic compounds within the material of the nucleus. Data from the COSAC instrument are expected to provide important insights into the early history of our solar system and contribute to our knowledge of small bodies that may have seeded the early Earth through impacts. In this paper we review recent developments in cometary science, including new data on target comet 67P/Churyumov-Gerasimenko. We report on laboratory measurements and the calibration of the COSAC instrument as well as the preparation for operations on the nucleus of comet 67P/Churyumov-Gerasimenko.
Published: 2014
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43. Supporting Mars exploration: BIOMEX in Low Earth Orbit and further astrobiological studies on the Moon using Raman and PanCam technology

Author: Thomas Leya, Ulrich Szewzyk, Mickael Baqué, Elke Rabbow, Jörg Fritz, René Demets, Pascale Ehrenfreund, Laura Zucconi, Laura Selbmann, Jean-Pierre de Vera, Paloma Serrano, Björn Huwe, C. Meyer, Andreas Elsaesser, Heinz-Wilhelm Hübers, Caroline Lange, Ralf Möller, F. J. Sánchez, Silvano Onofri, Daniela Billi, J. Meessen, Dana Grunow, Jochen Jänchen, Frances Westall, Nicole Schmitz, N. Feyh, Natalia Kozyrovska, Bernard Foing, Maria Bohmeier, Rosa de la Torre Noetzel, Ralf Jaumann, Tilman Spohn, Petra Rettberg, Thomas Berger, Sieglinde Ott, Charles S. Cockell, Dirk Wagner, Ute Boettger, Howell G. M. Edwards, Günther Reitz, Casey Bryce, Jasmin Joshi, Gerda Horneck, DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] ( DLR ), Instituto Nacional de Técnica Aeroespacial ( INTA ), Technische Universität Berlin ( TUB ), Università degli Studi di Roma Tor Vergata [Roma], Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] ( IBMM ), Ecole Nationale Supérieure de Chimie de Montpellier ( ENSCM ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Deutsches Zentrum für Luft- und Raumfahrt [Köln] ( DLR ), Centre de biophysique moléculaire ( CBM ), Université d'Orléans ( UO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Technische Hochschule Wildau ( TH Wildau ), Centre Pluridisciplinaire Textes et Cultures ( CPTC ), Université de Bourgogne ( UB ), Museum für Naturkunde [Berlin], Università degli studi della Tuscia [Viterbo], National Academy of Sciences of Ukraine ( NASU ), Fraunhofer - Institut für Biomedizinische Technik ( IBMT ), European Space Research and Technology Centre ( ESTEC ), European Space Agency ( ESA ), School of Physics and Astronomy [Edinburgh], University of Edinburgh, Design of Distributed Operating Systems ( SOLIDOR ), Institut de Recherche en Informatique et Systèmes Aléatoires ( IRISA ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National des Sciences Appliquées - Rennes ( INSA Rennes ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National des Sciences Appliquées - Rennes ( INSA Rennes ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Centre National de la Recherche Scientifique ( CNRS ) -INRIA Rennes, Institut National de Recherche en Informatique et en Automatique ( Inria ), GeoForschungsZentrum - Helmholtz-Zentrum Potsdam ( GFZ ), Joint Center for Structural Genomics ( JCSG ), Stanford University [Stanford], Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung ( AWI ), University of Sheffield [Sheffield], University of Bradford, Universität Potsdam, Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Space Policy Institute [Washington], George Washington University ( GW ), Heinrich-Heine-Universität Düsseldorf [Düsseldorf], DLR Institute of Planetary Research, German Aerospace Center ( DLR ), Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Instituto Nacional de Técnica Aeroespacial (INTA), Technische Universität Berlin (TU), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Deutsches Zentrum für Luft- und Raumfahrt [Köln] (DLR), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Technische Hochschule Wildau (TH Wildau), Centre Pluridisciplinaire Textes et Cultures (CPTC), Université de Bourgogne (UB), National Academy of Sciences of Ukraine (NASU), Fraunhofer Institute for Biomedical Engineering [Sulzbach] (Fraunhofer IBMT), Fraunhofer (Fraunhofer-Gesellschaft), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), SUPA School of Physics and Astronomy [Edinburgh], GeoForschungsZentrum - Helmholtz-Zentrum Potsdam (GFZ), Joint Center for Structural Genomics (JCSG), Stanford University, Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), The George Washington University (GW), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], German Aerospace Center (DLR), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Design of Distributed Operating Systems (SOLIDOR), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-INRIA Rennes, Institut National de Recherche en Informatique et en Automatique (Inria), and Publica
Subjects: BIOMEX, Settore BIO/01, Mars, 550 - Earth sciences, Life on Mars, Exploration of Mars, 01 natural sciences, 7. Clean energy, Space exploration, Astrobiology, Lunar Lander, 03 medical and health sciences, 0103 physical sciences, International Space Station, Low Earth Orbit, Biosignature, Space research, Moon, 010303 astronomy & astrophysics, Lunar lander, Instrumentation, Spectroscopy, 030304 developmental biology, 0303 health sciences, Institut für Physik und Astronomie, Astronomy and Astrophysics, Mars Exploration Program, Lithopanspermia, 13. Climate action, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Environmental science, Extraterrestrial Environment, Exploration, [ SDU ] Sciences of the Universe [physics]
Abstract: International audience; The Low Earth Orbit (LEO) experiment Biology and Mars Experiment (BIOMEX) is an interdisciplinary and international space research project selected by ESA. The experiment will be accommodated on the space exposure facility EXPOSE-R2 on the International Space Station (ISS) and is foreseen to be launched in 2013. The prime objective of BIOMEX is to measure to what extent biomolecules, such as pigments and cellular components, are resistant to and able to maintain their stability under space and Mars-like conditions. The results of BIOMEX will be relevant for space proven biosignature definition and for building a biosignature data base (e.g. the proposed creation of an international Raman library). The library will be highly relevant for future space missions such as the search for life on Mars. The secondary scientific objective is to analyze to what extent terrestrial extremophiles are able to survive in space and to determine which interactions between biological samples and selected minerals (including terrestrial, Moon- and Mars analogs) can be observed under space and Mars-like conditions. In this context, the Moon will be an additional platform for performing similar experiments with negligible magnetic shielding and higher solar and galactic irradiation compared to LEO. Using the Moon as an additional astrobiological exposure platform to complement ongoing astrobiological LEO investigations could thus enhance the chances of detecting organic traces of life on Mars. We present a lunar lander mission with two related objectives: a lunar lander equipped with Raman and PanCam instruments which can analyze the lunar surface and survey an astrobiological exposure platform. This dual use of testing mission technology together with geo- and astrobiological analyses will significantly increase the science return, and support the human preparation objectives. It will provide knowledge about the Moon′s surface itself and, in addition, monitor the stability of life-markers, such as cells, cell components and pigments, in an extraterrestrial environment with much closer radiation properties to the surface of Mars. The combination of a Raman data base of these data together with data from LEO and space simulation experiments, will lead to further progress on the analysis and interpretation of data that we will obtain from future Moon and Mars exploration missions.
Published: 2012
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44. Who Matters Most? Migrant Networks, Tie Strength, and First Rural-Urban Migration to Dakar

Author: Yacine Boujija, Simona Bignami, Valérie Delaunay, John Sandberg, Université de Montréal (UdeM), Laboratoire Population-Environnement-Développement (LPED), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), and The George Washington University (GW)
Subjects: Rural Population, Transients and Migrants, Urban Population, Social cap i tal, Population Dynamics, Social net works, Humans, Migrant net works, Internal migra tion, Emigration and Immigration, Senegal, Demography, [SHS]Humanities and Social Sciences
Abstract: Social net works' influ ence on migra tion has long been explored largely through the lenses of cumu la tive cau sa tion and social cap i tal the ory. This arti cle aims to reconceptualize ele ments of these the o ries for the case of rural-urban migra tion and test their util ity in explaining first-migra tion tim ing. We use a uniquely exten sive social net work sur vey linked to pro spec tively col lected migra tion data in rural Senegal. We decom pose migrant net works into return migrants, cur rent migrants, and non mi grant res i dents of the des ti na tion to cap ture het ero ge ne ity in migra tion-rel e vant social cap i tal. As expected, the num ber of non mi grant alters liv ing in the cap i tal, Dakar, has an outsized asso ci a tion with the migra tion haz ard, the num ber of cur rent migrants from the vil lage liv ing in Dakar has a smaller asso ci a tion, and the num ber of return migrants has lit tle asso ci a tion. Drawing on social cap i tal the ory, we test the influ ence of (1) sub jectively assessed tie strength between the ego and their net work alters and (2) struc tur ally weak ties mea sured through sec ond-order ("friend of a friend") con nec tions. Weak and strong sub jec tive ties to cur rent migrants and non mi grant Dakar res i dents are pos i tively asso ci ated with the first-migra tion haz ard. Structurally weak ties to cur rent migrants are too, but only for indi vid u als with no direct ties to cur rent migrants.
Published: 2022
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45. Long-term exposure to air pollution and incidence of adult-onset asthma and COPD: systematic review and meta-analyses

Author: Zhang, J., Liu, S., Lim, Brian, Thurston, G., Khreis, H., Hofffmann, B., Anenberg, S., Jacquemin, B., Nieuwenhuijsen, M.J., Andersen, Z. J., University of Copenhagen = Københavns Universitet (UCPH), New York University [New York] (NYU), NYU System (NYU), University of Cambridge [UK] (CAM), Texas A&M University System, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], The George Washington University (GW), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), and Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal)
Subjects: [SDV]Life Sciences [q-bio]
Abstract: International audience
Published: 2022
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46. Renormalization as a functor on bialgebras

Author: William Schmitt, Christian Brouder, Institut de minéralogie et de physique des milieux condensés (IMPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Department of Mathematics [George Washington University] (GW), The George Washington University (GW), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Symmetric algebra, High Energy Physics - Theory, Pure mathematics, Algebra and Number Theory, Quantum group, High Energy Physics::Lattice, 010102 general mathematics, Mathematics::Rings and Algebras, FOS: Physical sciences, Representation theory of Hopf algebras, Tensor algebra, 16. Peace & justice, Quasitriangular Hopf algebra, Hopf algebra, 01 natural sciences, Bialgebra, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], High Energy Physics - Theory (hep-th), Mathematics::Category Theory, Mathematics::Quantum Algebra, 0103 physical sciences, Associative algebra, 010307 mathematical physics, 0101 mathematics, Mathematics
Abstract: The Hopf algebra of renormalization in quantum field theory is described at a general level. The products of fields at a point are assumed to form a bialgebra B and renormalization endows T(T(B)^+), the double tensor algebra of B, with the structure of a noncommutative bialgebra. When the bialgebra B is commutative, renormalization turns S(S(B)^+), the double symmetric algebra of B, into a commutative bialgebra. The usual Hopf algebra of renormalization is recovered when the elements of B are not renormalised, i.e. when Feynman diagrams containing one single vertex are not renormalised. When B is the Hopf algebra of a commutative group, a homomorphism is established between the bialgebra S(S(B)^+) and the Faa di Bruno bialgebra of composition of series. The relation with the Connes-Moscovici Hopf algebra of diffeomorphisms is given. Finally, the bialgebra S(S(B)^+) is shown to give the same results as the standard renormalisation procedure for the scalar field., 24 pages, no figure. Several changes in the connection with standard renormalization
Published: 2007
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47. H4 abrupt event and late Neanderthal presence in Iberia

Author: Masa Kageyama, Pierre Sepulchre, Francesco d'Errico, Marian Vanhaeren, Gilles Ramstein, María-Fernanda Sánchez-Goñi, Gerhard Krinner, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Modélisation du climat (CLIM), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Archéologies et Sciences de l'Antiquité (ArScAn), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de glaciologie et géophysique de l'environnement (LGGE), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Environnements et Paléoenvironnements OCéaniques (EPOC), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Department of Anthropology, The George Washington University (GW), European Science Foundation (OMLL and Euroclimate programmes-EC Sixth Framework Programme under Contract no. ERAS-CT-2003-980409)., Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Université Panthéon-Sorbonne (UP1)-Université Paris Nanterre (UPN)-Institut national de recherches archéologiques préventives (Inrap)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Campus box 1114, Washington University, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE), George Washington University (GW), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS), and Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE)
Subjects: 010506 paleontology, Neanderthal, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, abrupt event, 01 natural sciences, Quaternary, Aurignacian, Paleontology, Geochemistry and Petrology, Peninsula, biology.animal, Paleoclimatology, paleoclimate, Earth and Planetary Sciences (miscellaneous), 0601 history and archaeology, [SDU.STU.GL]Sciences of the Universe [physics]/Earth Sciences/Glaciology, 0105 earth and related environmental sciences, Neanderthals, geography, Extinction, geography.geographical_feature_category, 060102 archaeology, biology, Mousterian, 06 humanities and the arts, Vegetation, 15. Life on land, Before Present, Heinrich, Geophysics, Oceanography, 13. Climate action, Space and Planetary Science, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, Geology
Abstract: International audience; Heinrich event 4 (H4) is well documented in the North Atlantic Ocean and the adjacent continents as a cooling event 39,000 yr before present (BP). To quantify the impact of this event with respect to climate and vegetation over the Iberian Peninsula, we perform numerical experiments using a high-resolution general circulation model forced by sea surface temperatures before and during H4. Our model simulates an expansion of aridity over the peninsula during H4, a desertification of the south, and a replacement of arboreal by herbaceous plants in the north, all of which are in agreement with contemporaneous pollen sequences from marine cores located off the Iberian Peninsula. Our simulations demonstrate that the H4 marine event imprinted drastic changes over Southern Iberia, which would not have favoured its occupation by Anatomically Modern Humans, therefore providing a plausible explanation for the delayed extinction of Neanderthals in this region inferred from the archaeological record.
Published: 2007
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48. A narrative review of functional outcomes following nerve-sparing surgery for deeply infiltrating endometriosis

Author: Sofiane Bendifallah, Beth Leopold, Thiers Soares, Sara Rahman, Jean Marc Ayoubi, Jordan S. Klebanoff, Gaby N. Moawad, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Gynécologie-obstétrique et médecine de la reproduction - Maternité [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Foch [Suresnes], Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Universidade do Estado do Rio de Janeiro [Rio de Janeiro] (UERJ), and The George Washington University (GW)
Subjects: endometriosis, medicine.medical_specialty, Constipation, Endocrinology, Diabetes and Metabolism, Endometriosis, Disease, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, nerve-sparing surgery, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, medicine, Endometriosis surgery, Molecular Biology, urinary retention, 030219 obstetrics & reproductive medicine, Nerve-sparing surgery, Urinary retention, business.industry, General surgery, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, constipation, General Medicine, medicine.disease, 3. Good health, functional outcomes, Sexual dysfunction, 030220 oncology & carcinogenesis, Narrative review, medicine.symptom, business
Abstract: Endometriosis negatively impacts the lives of countless women around the world. When medical management fails to improve the quality of life for women with either previously confirmed or suspected endometriosis often a decision must be made whether or not to proceed with surgery. When deeply infiltrating disease is diagnosed either clinically or by imaging studies often medical management alone will not suffice without excisional surgery. Surgery for endometriosis, especially deeply infiltrating disease, is not without risks. Aside from common risks of surgery endometriosis may also involve pelvic nerves, which can be hard to recognize to the untrained eye. Identification of pelvic nerves commonly encountered during endometriosis surgery is paramount to avoid inadvertent injury to optimize function outcomes. Injury to pelvic nerves can lead to urinary retention, constipation, sexual dysfunction, and refractory pain. However, nerve-sparing surgery for endometriosis has been proven to mitigate these complications and enhance recovery following surgery. Here we review the benefits of nerve-sparing surgery for deeply infiltrating disease.
Published: 2021
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49. Alternative routes to intravenous tranexamic acid for postpartum hemorrhage: A systematic search and narrative review

Author: Haleema Shakur‐Still, Stanislas Grassin‐Delyle, Kopalasuntharam Muhunthan, Homa K. Ahmadzia, David Faraoni, Monica Arribas, Ian Roberts, London School of Hygiene and Tropical Medicine (LSHTM), Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Foch [Suresnes], University of Jaffna, The George Washington University (GW), Baylor College of Medicine (BCM), Baylor University, We thank Katharine Ker for updating the literature searches for this review., and HAL UVSQ, Équipe
Subjects: [SDV]Life Sciences [q-bio], Obstetrics and Gynecology, General Medicine, administration routes, Antifibrinolytic Agents, tranexamic acid, [SDV] Life Sciences [q-bio], antifibrinolytic pharmacokinetics, postpartum hemorrhage, Pregnancy, pharmacodynamics, Humans, Administration, Intravenous, Female, Tablets
Abstract: International audience; Objective: To review available data on tranexamic acid (TXA) plasma concentration needed to inhibit fibrinolysis and the time to achieve this concentration when giving TXA by different routes in humans. To identify ongoing trials assessing alternatives to intravenous TXA administration. Methods: We updated two previous systematic reviews by searching MEDLINE, EMBASE, OviSP, and ISI Web of Science from database inception to July 2021. We also searched the WHO International Clinical Trials Registry Platform for ongoing trials to July 2021. Titles and abstracts were screened for relevant trials. Two reviewers independently reviewed and agreed the trials to be included. Results: Plasma TXA concentrations over 10 mg/L provide near maximal inhibition of fibrinolysis, with concentrations over 5 mg/L providing partial inhibition. Oral TXA tablets take about 1 h to reach a plasma concentration of 5 mg/L in postpartum women. Studies in healthy volunteers and shocked trauma patients show that intramuscular TXA achieves a plasma level of over 10 mg/L within 15 min. One trial is ongoing to determine the pharmacokinetics of intramuscular and oral solution TXA in pregnant women. Conclusion: Intramuscular TXA in healthy volunteers and shocked trauma patients reaches therapeutic concentration rapidly. Oral TXA tablets take too long to reach the minimum therapeutic concentration in postpartum women.
Published: 2022
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50. Support for the association between the rare functional variant I425V of the serotonin transporter gene and susceptibility to obsessive compulsive disorder

Author: P. Pickering, Christopher Gillberg, Marie-Christine Mouren-Simeoni, Claudia Reck, Richard Delorme, Michael Wagner, Isabelle Roy, Philip Gorwood, Nadia Chabane, Catalina Betancur, Marie-Odile Krebs, Gudrun Nygren, Bruno Millet, Thomas Bourgeron, Friederike Buhtz, Phillip L. Pearl, Marion Leboyer, Jonas Melke, Henrik Anckarsäter, Christelle M. Durand, Stephan Ruhrmann, Amélie Kipman, Wolfgang Maier, Maria Råstam, Génétique Humaine et Fonctions Cognitives, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Neurobiologie et Psychiatrie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de psychopathologie de l'enfant et de l'adolescent, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Department of Psychiatry, Rheinische Friedrich-Wilhelms-Universität Bonn, Physiopathologie des Maladies Psychiatriques, Développement et Vulnérabilité, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Analyse Phenotypique, Developpementale et Genetique des Comportements Addictifs, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Children's National Medical Center, The George Washington University (GW), Department of Child and Adolescent Psychiatry, University of Gothenburg (GU), University of Greifwald, Department of Psychiatry and Psychotherapy, University of Cologne, Département de Psychiatrie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Albert Chenevier, Saint George's Hospital Medical School, Université Paris Diderot - Paris 7 (UPD7), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 ( UPD7 ), Bonn Universität [Bonn], Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), George Washington University ( GW ), University of Gothenburg ( GU ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Albert Chenevier, Université Paris Diderot - Paris 7 ( UPD7 ), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Betancur, Catalina
Subjects: Male, Proband, Obsessive-Compulsive Disorder, Anorexia Nervosa, MESH : Polymorphism, Genetic, Drug Resistance, Alcohol abuse, [SDV.GEN] Life Sciences [q-bio]/Genetics, MESH: Child Development Disorders, Pervasive, 0302 clinical medicine, MESH : Child, Reference Values, MESH: Child, MESH : Obsessive-Compulsive Disorder, MESH : Female, Family history, Child, Serotonin transporter, ComputingMilieux_MISCELLANEOUS, Serotonin Plasma Membrane Transport Proteins, 0303 health sciences, MESH: Middle Aged, biology, MESH: Genetic Predisposition to Disease, Middle Aged, MESH : Adult, Pedigree, 3. Good health, Alcoholism, Psychiatry and Mental health, Anorexia nervosa (differential diagnoses), MESH : Anorexia Nervosa, MESH: Drug Resistance, Female, Psychology, MESH: Anorexia Nervosa, Selective Serotonin Reuptake Inhibitors, Clinical psychology, Adult, medicine.medical_specialty, Adolescent, MESH: Pedigree, MESH : Male, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, MESH: Alcoholism, MESH : Adolescent, mental disorders, MESH: Polymorphism, Genetic, Pervasive developmental disorder, medicine, Humans, MESH : Child Development Disorders, Pervasive, Family, Genetic Predisposition to Disease, MESH : Middle Aged, Rare functional variant, Psychiatry, Molecular Biology, MESH: Family, 030304 developmental biology, MESH: Adolescent, MESH: Obsessive-Compulsive Disorder, MESH : Drug Resistance, [SDV.GEN]Life Sciences [q-bio]/Genetics, Polymorphism, Genetic, MESH: Humans, MESH : Alcoholism, MESH : Humans, Schedule for Affective Disorders and Schizophrenia, MESH: Adult, medicine.disease, MESH: Male, Child Development Disorders, Pervasive, MESH : Pedigree, biology.protein, MESH : Family, MESH : Genetic Predisposition to Disease, [ SDV.GEN ] Life Sciences [q-bio]/Genetics, MESH: Female, 030217 neurology & neurosurgery
Abstract: SIR—Recently, a rare functional variant, I425V, in the serotonin transporter gene (SLC6A4) has been reported to be associated with a complex neuropsychiatric phenotype that includes obsessive-compulsive disorder (OCD), alcohol abuse/dependence, anorexia nervosa, and pervasive developmental disorder (PDD).1 Our study, performed in a large population of patients with these disorders, confirms the occurrence and the segregation of V425 in OCD. The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in numerous psychiatric disorders, mostly because of the efficacy of serotonin reuptake inhibitors (SRIs). Among the polymorphisms identified in SLC6A4, three have been shown to be functional. The rare I425V variation, located in exon 9, increases the transport activity of the protein2, whereas the two more frequent polymorphisms, 5-HTTLPR located in the 5′-UTR of the gene, and STin2 located in intron 2, modify the transcriptional activity of the gene3,4. Despite a large number of studies, the functional implications of the two frequent SLC6A4 polymorphisms in psychiatric disorders are still a matter of debate. In the present study, we sought to further explore the influence of the rare but clearly functional I425V variant in a large sample of patients with OCD and other psychiatric conditions previously reported in the two families carrying I425V, i.e., FDD, anorexia nervosa, and alcohol abuse/dependence. To be included in the study, patients had to meet the DSM-IV criteria for OCD, anorexia nervosa, alcohol abuse/dependence, or FDD. The diagnosis of FDD was confirmed using the Autism Diagnostic Interview-Revised.5 For the other disorders, lifetime psychiatric evaluation was carried out using the Diagnostic Interview for Genetic Studies (DIGS)6 for adult patients, or the Kiddie Schedule for Affective Disorders and Schizophrenia for children.7 Healthy controls were included after being interviewed with the DIGS and the Family Interview for Genetic Studies8 to confirm the absence of both personal and family history of major psychiatric disorders. The local Research Ethics Boards reviewed and approved the study. The V425 was found in 3/254 probands with OCD, 1/284 with PDD, 1/124 with anorexia nervosa, in 1/285 healthy controls, but not in alcohol abusers/dependents (0/128) (Table 1). In OCD family 1, V425 was transmitted by the father who also had a lifetime history of OCD and single phobia. The paternal grandfather was alcoholic and tobacco dependant. No genotypic information was available for the paternal grandparents since the grandfather died of throat cancer and the grandmother of breast cancer. In OCD family 2, the mother and two siblings of the proband had committed suicide and the father was also dead, so no genotypic information was available for these individuals. OCD case 1 had only one brother, who committed suicide some years ago, so no genotypic information was available for him. No other clinical data were available concerning the first-degree relatives of OCD case 1. In FDD family 1, V425 was transmitted by the father and was present in the proband and two brothers. The father and one of the brothers carrying the V425 were both alcohol dependent. However, the youngest brother (19 years old), also carrying the V425 variant, did not suffer from alcoholism or any other psychiatric disorder at the time of evaluation. Table 1 SCL6A4 genotypes and clinical features of the subjects included in the study Our results are in accordance with those previously reported by Ozaki et al1 on four points. First, we report a possibly higher occurrence of the V425 variant in OCD compared to controls. Although the variant is rare, the combined results of the two studies indicate a significantly higher frequency of V425 in OCD compared to controls1,9 (5/457 vs. 2/884, Fisher exact test, P= 0.02). Second, despite the limited clinical and genotypic information on the families carrying the V425 variant, our results suggest a possible co-segregation between the V425 and neuropsychiatric phenotypes, specifically in OCD. Third, Ozaki et al. hypothesized that the V425 variant may confer treatment-resistance to SRIs. This was indirectly supported by our findings since all OCD probands carrying the V425 variant in our study were considered resistant to SRIs, i.e., the severity of their obsessive and compulsive symptoms decreased less than 25% with multiple trials of a high dose of SRIs and a good compliance. Specifically, the three probands with OCD carrying the variant showed poor or no response to multiple trials of SRIs at adequate doses over several years. Fourth, the analysis of the two additional polymorphisms of the SCL6A4 gene indicated that the V425 polymorphism might be associated with the L allele of 5-HTTLPR. However, our results do not confirm the hypothesis of a combined gain of function effect of both V425 and L/L genotype as a genetic risk for OCD, since this combined genotype was not present in all affected patients and, by contrast, was present in the control subject carrying the V425 variant. In conclusion, our results are similar to those of the original report by Ozaki et al. and, therefore, lend support for a role of SLC6A4 V425 in the susceptibility to complex neuropsychiatric phenotypes. However, due to its global low frequency and to the fact that it was detected in a few controls, the role of V425 remains uncertain and should be interpreted with caution. We encourage other investigators, especially in the field of OCD, to screen for V425 in their samples. Indeed, the replication of these findings could ultimately implicate SLC6A4 as a true susceptibility gene to complex neuropsychiatric disorders, and consequently shed further light on the results obtained with the more frequent polymorphisms.
Published: 2005
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