1. Immunological and viral determinants of dengue severity in hospitalized adults in Ha Noi, Viet Nam.
- Author
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Annette Fox, Nguyen Minh Hoa Le, Cameron P Simmons, Marcel Wolbers, Heiman F L Wertheim, Thi Khuong Pham, Thi Hai Ninh Tran, Thi Minh Lien Trinh, Thi Lien Nguyen, Vu Trung Nguyen, Duc Hien Nguyen, Jeremy Farrar, Peter Horby, Walter R Taylor, and Van Kinh Nguyen
- Subjects
Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
The relationships between the infecting dengue serotype, primary and secondary infection, viremia and dengue severity remain unclear. This cross-sectional study examined these interactions in adult patients hospitalized with dengue in Ha Noi.158 patients were enrolled between September 16 and November 11, 2008. Quantitative RT-PCR, serology and NS1 detection were used to confirm dengue infection, determine the serotype and plasma viral RNA concentration, and categorize infections as primary or secondary. 130 (82%) were laboratory confirmed. Serology was consistent with primary and secondary infection in 34% and 61%, respectively. The infecting serotype was DENV-1 in 42 (32%), DENV-2 in 39 (30%) and unknown in 49 (38%). Secondary infection was more common in DENV-2 infections (79%) compared to DENV-1 (36%, p
- Published
- 2011
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