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Your search keyword '"Thiele, Jan Christoph"' showing total 16 results
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16 results on '"Thiele, Jan Christoph"'

2. Efficient solver for a special class of convection-diffusion problems

Author

Karedla, Narain, Thiele, Jan Christoph, Gregor, Ingo, and Enderlein, Jörg

Subjects
Physics - Computational Physics, Physics - Fluid Dynamics
Abstract

We describe an exact and highly efficient numerical algorithm for solving a special but important class of convection-diffusion equations. These equations occur in many problems in physics, chemistry, or biology, and they are usually hard to treat due to the presence of a convection term, represented by a first order derivative in the spatial co-ordinate. Our algorithm reduces the convection-diffusion equation to a pure diffusion problem within a complex-valued potential which can be solved efficiently and accurately using conventional parabolic partial differential equation solvers., Comment: 6 pages, 6 figures

Published
2018
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6. Doubling the resolution of fluorescence-lifetime single-molecule localization microscopy with image scanning microscopy

Author

Radmacher, Niels, Nevskyi, Oleksii, Gallea, José Ignacio, Thiele, Jan Christoph, Gregor, Ingo, Rizzoli, Silvio O., and Enderlein, Jörg

Abstract

In this study, we integrate a single-photon detector array into a confocal laser scanning microscope, enabling the combination of fluorescence-lifetime single-molecule localization microscopy with image scanning microscopy. This unique combination delivers a twofold improvement in lateral localization accuracy for single-molecule localization microscopy (SMLM) and maintains its simplicity. Moreover, the addition of lifetime information from our confocal laser scanning microscope eliminates chromatic aberration, particularly crucial for achieving few-nanometre resolution in SMLM. Our approach, named fluorescence-lifetime image scanning microscopy SMLM, is demonstrated through direct stochastic optical reconstruction microscopy and DNA point accumulation for imaging in nanoscale topography experiments on fluorescently labelled cells, showcasing both resolution enhancement and fluorescence-lifetime multiplexing capabilities.

Published
2024
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