Search

Your search keyword '"This study was supported by the TransEPI consortium funded by the Bill ' showing total 3 results
Start Over Author "This study was supported by the TransEPI consortium funded by the Bill
3 results on '"This study was supported by the TransEPI consortium funded by the Bill '

1. Development and validation of serological markers for detecting recent Plasmodium vivax infection

Author

Takafumi Tsuboi, Wang Nguitragool, Xavier C. Ding, Masayuki Morita, Iveth J. González, Zoe S J Liu, Eizo Takashima, Thomas Obadia, Rhea J. Longley, Christèle Huon, Wai-Hong Tham, Matthias Harbers, Fumie Matsuura, Marcus V. G. Lacerda, Jetsumon Sattabongkot, Michael T. White, Wuelton Marcelo Monteiro, Jessica Brewster, Julie Healer, Connie S N Li-Wai-Suen, Ivo Mueller, Carla Proietti, Chetan E. Chitnis, André Siqueira, James W. Kazura, Denise L. Doolan, Leanne J. Robinson, The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Mahidol University [Bangkok], Malaria : parasites et hôtes - Malaria : parasites and hosts, Institut Pasteur [Paris], Ehime University [Matsuyama], Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Burnet Institute [Melbourne, Victoria], CellFree Sciences Co., Ltd., Biologie de Plasmodium et Vaccins - Malaria Parasite Biology and Vaccines, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), Universidade do Estado do Amazonas (UEA), James Cook University (JCU), Queensland Institute of Medical Research, Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Foundation for Innovative New Diagnostics (FIND), Center for Global Health and Diseases, School of Medicine-Case Western Reserve University [Cleveland], Instituto Leônidas e Maria Deane - Fiocruz Amazônia [Manaus, Brésil] (ILMD), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), We acknowledge funding from the Global Health Innovative Technology Fund (T2015-142 to I.M.), the National Institute of Allergy and Infectious Diseases (National Institutes of Health grant 5R01 AI 104822 to J.S. and 5U19AI089686-06 to J.K.) and the National Health and Medical Research Council Australia (1092789 and 1134989 to I.M. and 1143187 to W.-H.T.). Cohort samples were derived from field studies originally funded by the TransEPI consortium (supported by the Bill and Melinda Gates Foundation). This work has been supported by FIND with funding from the Australian and British governments. We also acknowledge support from the National Research Council of Thailand. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council (NHMRC) Independent Research Institute Infrastructure Support Scheme. I.M. is supported by an NHMRC Senior Research Fellowship (1043345). D.L.D. is supported by an NHMRC Principal Research Fellowship (1023636). T.T. was supported in part by Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (KAKENHI, JP15H05276, JP16K15266). W.H.T. is a Howard Hughes Medical Institute–Wellcome Trust International Research Scholar (208693/Z/17/Z). R.J.L. received the Page Betheras Award from WEHI to provide funding for technical support for this project during parental leave. M.V.G.L. and W.M.M. are fellows of the Brazilian National Council for Scientific and Technological Development., Institut Pasteur [Paris] (IP), Ehime University [Matsuyama, Japon], Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)

Subjects
0301 basic medicine, Adult, Time Factors, Plasmodium vivax, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Immunoglobulin G, Serology, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Antigen, parasitic diseases, Malaria, Vivax, Prevalence, Medicine, Infection control, Humans, Serologic Tests, Longitudinal Studies, Child, Uncategorized, Infection Control, biology, business.industry, General Medicine, biology.organism_classification, medicine.disease, Thailand, 3. Good health, 030104 developmental biology, Early Diagnosis, 030220 oncology & carcinogenesis, Immunology, biology.protein, Biomarker (medicine), Melanesia, business, Malaria, Biomarkers, Brazil, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Cohort study
Abstract

International audience; A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59-69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy.

Published
2020
Full Text
View/download PDF

2. Highly heterogeneous residual malaria risk in western Thailand

Author

Michael T. White, Wang Nguitragool, Pratap Singhasivanon, Ivo Mueller, Ingrid Felger, Jetsumon Sattabongkot, Stephan Karl, Cristian Koepfli, Mahidol University [Bangkok], The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Papua New Guinea Institute of Medical Research (PNG-IMR), Malaria : parasites et hôtes - Malaria : parasites and hosts, Institut Pasteur [Paris], Medical Parasitology and Infection Biology [Basel, Suisse] (MPI), Swiss Tropical and Public Health Institute [Basel], This study was supported by the TransEPI consortium funded by the Bill & Melinda Gates Foundation, USA (www.gatesfoundation.org), a National Health and Medical Research Council (NHMRC) Project Grant, Australia (#1021455, www.nhmrc.gov.au), and Swiss National Science Foundation grant (310030_159580, www.snf.ch). WN was supported by a Wellcome Trust Intermediate Fellowship in Public Health and Tropical Medicine, United Kingdom (101073/Z/13Z). IM was supported by a NHMRC Senior Research Fellowship (#1043345) and JS was supported by the National Institutes of Health, USA (# 5R01 AI 104822)., and Institut Pasteur [Paris] (IP)

Subjects
0301 basic medicine, Male, Epidemiology, [SDV]Life Sciences [q-bio], Plasmodium vivax, Indoor residual spraying, Force of infection, Myanmar, Cohort Studies, 0302 clinical medicine, MESH: Aged, 80 and over, Risk Factors, MESH: Risk Factors, MESH: Child, Prevalence, MESH: Animals, Longitudinal Studies, Prospective Studies, MESH: Incidence, Malaria, Falciparum, Child, MESH: Longitudinal Studies, MESH: Travel, MESH: Cohort Studies, Aged, 80 and over, MESH: Aged, Travel, Farmers, MESH: Middle Aged, biology, Incidence, MESH: Malaria, Falciparum, Anopheles, Middle Aged, MESH: Myanmar, Thailand, MESH: Infant, 3. Good health, Infectious Diseases, MESH: Young Adult, Child, Preschool, Population study, Female, MESH: Mosquito Vectors, Seasons, medicine.symptom, Adult, Adolescent, MESH: Farmers, 030231 tropical medicine, Plasmodium falciparum, Mosquito Vectors, Asymptomatic, Article, MESH: Anopheles, 03 medical and health sciences, Young Adult, MESH: Cross-Sectional Studies, Environmental health, parasitic diseases, medicine, Malaria, Vivax, Animals, Humans, MESH: Thailand, MESH: Prevalence, ComputingMethodologies_COMPUTERGRAPHICS, Aged, MESH: Adolescent, MESH: Humans, MESH: Child, Preschool, Infant, MESH: Malaria, Vivax, MESH: Adult, biology.organism_classification, medicine.disease, MESH: Male, MESH: Prospective Studies, Malaria, 030104 developmental biology, Cross-Sectional Studies, Parasitology, MESH: Female, MESH: Seasons
Abstract

Graphical abstract, Highlights • There is a highly heterogenous risk of malaria infection among villagers in western Thailand. • The molecular force of infection was determined in a low endemic setting. • There is a strong correlation between malaria prevalence and the force of infection., Over the past decades, the malaria burden in Thailand has substantially declined. Most infections now originate from the national border regions. In these areas, the prevalence of asymptomatic infections is still substantial and poses a challenge for the national malaria elimination program. To determine epidemiological parameters as well as risk factors for malaria infection in western Thailand, we carried out a cohort study in Kanchanaburi and Ratchaburi provinces on the Thailand-Myanmar border. Blood samples from 999 local participants were examined for malaria infection every 4 weeks between May 2013 and Jun 2014. Prevalence of Plasmodium falciparum and Plasmodium vivax was determined by quantitative PCR (qPCR) and showed a seasonal variation with values fluctuating from 1.7% to 4.2% for P. vivax and 0% to 1.3% for P. falciparum. Ninety percent of infections were asymptomatic. The annual molecular force of blood-stage infection (molFOB) was estimated by microsatellite genotyping to be 0.24 new infections per person-year for P. vivax and 0.02 new infections per person-year for P. falciparum. The distribution of infections was heterogenous, that is, the vast majority of infections (>80%) were found in a small number of individuals (

Published
2019
Full Text
View/download PDF

3. Infectivity of symptomatic and asymptomatic Plasmodium vivax infections to a Southeast Asian vector, Anopheles dirus

Author

Wanlapa Roobsoong, Sureemas Buates, Chayanut Suansomjit, Wang Nguitragool, Teerawat Saeseu, Thomas Obadia, Patchara Sriwichai, Jetsumon Sattabongkot, Liwang Cui, Kirakorn Kiattibutr, Nattawan Rachaphaew, Ivo Mueller, Mahidol University [Bangkok], Malaria : parasites et hôtes - Malaria : parasites and hosts, Institut Pasteur [Paris], Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), The Walter and Eliza Hall Institute of Medical Research (WEHI), Pennsylvania State University (Penn State), Penn State System, This study was supported by the TransEPI consortium funded by the Bill & Melinda Gates Foundation, USA (www.gatesfoundation.org) and National Institutes of Health, USA, International Centers of Excellence in Malaria Research grant (U19 AI089672, www.niaid.nih.gov). We greatly appreciate the contribution to microscopic examinations of blood samples by Mrs. Nongnuj Maneechai. IM is supported by a National Health and Medical Research Council of Australia Senior Research Fellowship. WN is supported by a UK Wellcome Trust Intermediate Fellowship in Public Health and Tropical Medicine., Institut Pasteur [Paris] (IP), and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Disease reservoir, Plasmodium vivax, MESH: Asia, Southeastern, Parasitemia, 0302 clinical medicine, Anopheles dirus, MESH: Animals, Malaria, Falciparum, Asia, Southeastern, Membrane feeding assay, biology, MESH: Malaria, Falciparum, Anopheles, 3. Good health, MESH: Plasmodium vivax, Infectious Diseases, Female, MESH: Mosquito Vectors, medicine.symptom, Adolescent, 030231 tropical medicine, Mosquito Vectors, Southeast asian, Asymptomatic, Article, MESH: Anopheles, 03 medical and health sciences, parasitic diseases, Malaria, Vivax, medicine, Animals, Humans, Transmission, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Disease Reservoirs, MESH: Adolescent, MESH: Disease Reservoirs, MESH: Humans, MESH: Malaria, Vivax, medicine.disease, biology.organism_classification, Virology, Malaria, 030104 developmental biology, Infectivity, Parasitology, MESH: Female
Abstract

International audience; Plasmodium vivax is now the predominant species causing malarial infection and disease in most non-African areas, but little is known about its transmission efficiency from human to mosquitoes. Because the majority of Plasmodium infections in endemic areas are low density and asymptomatic, it is important to evaluate how well these infections transmit. Using membrane feeding apparatus, Anopheles dirus were fed with blood samples from 94 individuals who had natural P. vivax infections with parasitemias spanning four orders of magnitude. We found that the mosquito infection rate was positively correlated with blood parasitemia and that infection began to rise when parasitemia was >10 parasites/ll. Below this threshold, mosquito infection is rare and associated with very few oocysts. These findings provide useful information for assessing the human reservoir of transmission and for establishing diagnostic sensitivity required to identify individuals who are most infective to mosquitoes.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results