1. Circulating IL-10 is associated with reduced risk of prostate cancer in a prospective cohort of elderly men: the MrOS Study
- Author
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Thomas, Claire E, Bauer, Douglas C, Yuan, Jian-Min, and Cauley, Jane A
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Aging ,Prevention ,Cancer ,Prostate Cancer ,Urologic Diseases ,2.1 Biological and endogenous factors ,Aetiology ,Inflammatory and immune system ,Male ,Humans ,Aged ,Interleukin-10 ,Risk Factors ,Prospective Studies ,Inflammation ,Biomarkers ,Cytokines ,Interleukin-6 ,Prostatic Neoplasms ,Prostate cancer ,IL-10 ,Molecular epidemiology ,Public Health and Health Services ,Epidemiology ,Oncology and carcinogenesis - Abstract
PurposeProstate cancer (PCa) is the most commonly diagnosed cancer in men, resulting in a large cancer burden given a relatively higher 5-year survival rate of patients after cancer diagnosis. The underlying etiology of prostate cancer is not well understood. Chronic inflammation plays a significant role in carcinogenesis overall and may be involved in the development of PCa, but immune-related biomarker studies in prostate cancer are limited.MethodsThe associations of serum concentrations of cytokines, systemic immune biomarkers, with risk of PCa were assessed in a randomly selected sub-cohort (n = 798, mean age = 73 years) of the Osteoporotic Fractures in Men (MrOS) study, a prospective cohort of older men. At baseline, we measured serum interleukin (IL)-6, C-reactive protein (CRP), tumor necrosis factor alpha (TNFα), soluble receptors (SR) of IL-6 (IL-6SR) and TNF (TNFαSR1 and TNFαSR2), and IL-10. The risk of PCa was calculated for higher tertile levels of measured individual cytokines relative to the lowest tertile using Cox proportional hazards regression models.ResultsAfter an average 6 years of follow-up, 59 men developed incident PCa. Men in the middle or highest tertile of IL-10 had a statistically significant 50% lower risk of PCa compared to the lowest tertile (hazard ratio = 0.50, 95% confidence interval = 0.30-0.84). There was no significant association between any of the other cytokines measured and PCa risk.ConclusionIL-10, an anti-inflammatory cytokine, was associated with lower risk of PCa. Further research of IL-10 and inflammation in relation to PCa development is warranted.
- Published
- 2023