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3. Optimized workflow of EV enrichment from human plasma samples for downstream mass spectrometry analysis

Author

Patrick Erwied, Yi Gu, Lena Simon, Martin Schneider, Dominic Helm, Maurice Stefan Michel, Philipp Nuhn, Katja Nitschke, and Thomas Stefan Worst

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract To improve the prognosis of bladder and prostate cancer, highly specific and sensitive biomarkers are needed for early detection, prognosis prediction, and therapeutic stratification. Extracellular vesicles (EV) from plasma could fill this gap due to their potential to serve as cancer biomarkers. However, the enrichment of EV is a major challenge, because the highly abundant plasma proteins are interfering with analytical downstream applications like mass spectrometry (MS). Therefore, the purity requirements of the EV samples must be carefully considered when selecting or developing a suitable EV enrichment method. The aim of this study was to compare a self-designed EV enrichment method based on density cushion centrifugation (DCC) combined with size exclusion chromatography (SEC) and concentration (method 1) with the exoRNeasy midi kit from Qiagen (method 2) and with unprocessed plasma. Furthermore, the single steps of method 1 were evaluated for their effectiveness to enrich EV from plasma. The results showed that the EV samples enriched with method 1 contained the highest levels of EV and exosome markers with simultaneously low levels of highly abundant plasma proteins. In summary, the combination of DCC, SEC and concentration proved to be a promising approach to discover EV-based biomarkers from plasma of cancer patients.

Published
2024
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4. Introduction

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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5. Orthogonal Groups with Witt Defect 0

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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6. Proofs of the Main Theorems

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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7. Odd Dimensional Orthogonal Groups

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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8. Unitary Groups

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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9. Orthogonal Groups with Witt Defect 1

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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10. Preliminaries

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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11. Degenerate Normal 2-Coverings

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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12. Symplectic Groups

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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13. Linear Groups

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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14. Almost Simple Groups Having Socle a Sporadic Simple Group

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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15. Dropping the Maximality

Author

Bubboloni, Daniela, Spiga, Pablo, Weigel, Thomas Stefan, Morel, Jean-Michel, Editor-in-Chief, Teissier, Bernard, Editor-in-Chief, Baur, Karin, Series Editor, Brion, Michel, Series Editor, Frank, Rupert, Series Editor, Huber, Annette, Series Editor, Khoshnevisan, Davar, Series Editor, Kontoyiannis, Ioannis, Series Editor, Kunoth, Angela, Series Editor, Mézard, Ariane, Series Editor, Podolskij, Mark, Series Editor, Policott, Mark, Series Editor, Székelyhidi, László, Series Editor, Vezzosi, Gabriele, Series Editor, Wienhard, Anna, Series Editor, Stroppel, Catharina, Advisory Editor, Di Bernardo, Mario, Advisory Editor, Lugosi, Gábor, Advisory Editor, De Lellis, Camillo, Series Editor, Figalli, Alessio, Series Editor, Serfaty, Sylvia, Series Editor, Bubboloni, Daniela, Spiga, Pablo, and Weigel, Thomas Stefan

Published
2024
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22. Prognostic significance of EGFR, AREG and EREG amplification and gene expression in muscle invasive bladder cancer

Author

Daniel Uysal, Blerta Thaqi, Alexander Fierek, David Jurgowski, Zoran V. Popovic, Fabian Siegel, Maurice Stephan Michel, Philipp Nuhn, Thomas Stefan Worst, Philipp Erben, and Katja Nitschke

Subjects
EGFR, AREG, EREG, bladder cancer, gene expression, survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

IntroductionMuscle invasive bladder cancer (MIBC) remains a prevalent cancer with limited therapeutic options, obviating the need for innovative therapies. The epidermal growth factor receptor (EGFR) is a linchpin in tumor progression and presents a potential therapeutic target in MIBC. Additionally, the EGFR ligands AREG and EREG have shown associations with response to anti-EGFR therapy and improved progression-free survival in colorectal carcinoma.Materials and methodsWe investigated the prognostic significance of EGFR, AREG, and EREG in MIBC. Gene expression and copy number analyses were performed via qRT-PCR on tissue samples from 100 patients with MIBC who underwent radical cystectomy at the University Hospital Mannheim (MA; median age 72, interquartile range [IQR] 64–78 years, 25% female). Results were validated in 361 patients from the 2017 TCGA MIBC cohort (median age 69, IQR 60–77 years, 27% female), in the Chungbuk and MDACC cohort. Gene expressions were correlated with clinicopathologic parameters using the Mann-Whitney test, Kruskal-Wallis- test and Spearman correlation. For overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS) gene expression was analyzed with Kaplan-Meier and Cox-proportional hazard models.ResultsSignificant gene expression differences in EGFR, AREG, and EREG could be detected in all cohorts. In the TCGA cohort, EGFR expression was significantly elevated in patients with EGFR amplification and KRAS wildtype. High AREG expression independently predicted longer OS (HR = 0.35, CI 0.19 - 0.63, p = 0.0004) and CSS (HR = 0.42, CI 0.18 – 0.95, p = 0.0378) in the MA cohort. In the TCGA cohort, high EGFR, AREG, and EREG expression correlated with shorter OS (AREG: HR = 1.57, CI 1.12 – 2.20, p = 0.0090) and DFS (EGFR: HR = 1.91, CI 1.31 – 2.8, p = 0.0008). EGFR amplification was also associated with reduced DFS.DiscussionHigh EGFR and EREG indicate worse survival in patients with MIBC. The prognostic role of AREG should further be investigated in large, prospective series. Divergent survival outcomes between the four cohorts should be interpreted cautiously, considering differences in analysis methods and demographics. Further in vitro investigations are necessary to elucidate the functional mechanisms underlying the associations observed in this study.

Published
2024
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24. Optimization of extracellular vesicles preparation from saliva of head and neck cancer patients

Author

Luisa Tengler, Moritz Tiedtke, Julia Schütz, Karen Bieback, Stefanie Uhlig, Marie-Nicole Theodoraki, Katja Nitschke, Thomas Stefan Worst, Elena Seiz, Claudia Scherl, Nicole Rotter, and Sonja Ludwig

Subjects
Medicine, Science
Abstract

Abstract Small extracellular vesicles from saliva (SEVs) have high potential as biomarkers in Head and Neck cancer (HNC). However, there is no common consensus on the ideal method for their isolation. This study compared different ultracentrifugation (UC) methods (durations and + /− additional purification) with size exclusion chromatography (SEC) and investigated the potential of SEVs as diagnostic biomarkers and their biological activity on NK and CD8+ T cells. SEVs from 19 HNC patients and 8 healthy donors (HDs) were thoroughly characterized. Transmission electron microscopy confirmed the isolation of vesicles by all methods. The average size determined via nanoparticle-tracking analysis was smaller for SEVs isolated by SEC than UC. The highest particle-to-protein yield was achieved by UC (3 h + 3 h) (UCopt) and SEC. However, SEC yielded considerably fewer SEVs. Comparing the surface marker cargo, SEVs isolated by UCopt from HNC patients carried more PD-L1, FasL, and TGF-β than SEVs from HDs. These levels correlated with tumor stage and HPV status. SEVs downregulated NKG2D expression on primary NK cells. HNC SEVs accelerated CD8+ T cell death compared to HD SEVs. This study suggests that UCopt is preferable when isolation of a high particle-to-protein load is required. Especially PD-L1 and FasL on SEVs hold substantial potential as diagnostic biomarkers.

Published
2024
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26. Unbegleitete minderjährige Geflüchtete

Author

Thomas, Stefan, Sauer, Madeleine, and Zalewski, Ingmar

Subjects
Unaccompanied Minor Refugees, Germany, Brandenburg, Life Situation, Subjective Perspective, Organisational Culture, Integration, Fleeing, Education, Politics, Refugee Studies, Social Work, Youth, Qualitative Social Research, Pedagogy, Unbegleitete Minderjährige Flüchtlinge, Deutschland, Lebenssituation, Subjektperspektive, Organisationskultur, Flucht, Bildung, Politik, Flüchtlingsforschung, Sozialarbeit, Jugend, Qualitative Sozialforschung, Pädagogik, bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFD Refugees & political asylum
Abstract

This volume analyses life situations and perspectives of unaccompanied minor refugees in Germany from subjective, institutional and structural perspectives., Wie sind die Lebenssituationen und Perspektiven unbegleiteter minderjähriger Geflüchteter in Deutschland? Was sind förderliche Organisationskulturen, die eine gelingende Versorgung und Betreuung ermöglichen? Durch eine dreifache Perspektivübernahme gehen die Autor_innen diesen Fragen nach: Gemeinsam mit geflüchteten Jugendlichen nehmen sie die Subjektperspektive ein und erforschen die Sicht der Jugendlichen auf ihr Leben in Deutschland. Aus der Einrichtungsperspektive evaluieren sie, wie Probleme und Herausforderungen in den Einrichtungen bearbeitet werden. Und mit dem Blick aus der Strukturperspektive untersuchen sie schließlich die sozialräumliche Einbettung und fragen nach Faktoren, die die Teilhabe der jungen Geflüchteten am gesellschaftlichen Leben begünstigen.

Published
2018
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36. Monitoring and Evaluating Work-Based Learning in Vocational Education and Training: A Handbook for Policy Makers and Social Partners

Author

European Training Foundation (ETF) (Italy), Grollmann, Philipp, Hugo, Frederik, Thomas, Stefan, and Wittig, Wolfgang

Abstract

Interested in managing existing work-based learning schemes by incorporating monitoring and evaluation methods? Following a brief discussion of the concept of work-based learning, this handbook presents the rationale for monitoring and evaluation as part of good governance. The functioning of work-based learning schemes is represented by a process model comprising four stages: input, process, output and outcome. For each of these four stages, examples of relevant indicators and tools from several countries around the globe are presented. These tools cover the following topics: support from companies and learners, financial resources, costs and benefits, curriculum design, quality of training staff, organisation of the learning process, use of digital technologies, assessment of learners, learning achievements, and labour-market outcomes.

Published
2021

39. Centres of Vocational Excellence: An Engine for Vocational Education and Training Development. An International Study

Author

European Training Foundation (ETF) (Italy), Arribas, Jose Manuel Galvin, Zisimos, Georgios, Thomas, Stefan, Vuorinen, Pirita, and Stanley, Julian

Abstract

What is vocational excellence, why is it important, and how is it developed and for whom? This paper tries to: address the complexity of vocational excellence; explain the different types of centres of vocational excellence (CoVEs), which embody vocational excellence, their missions and functions; and identify good practices that work well in different contexts. The paper investigates issues such as: How can CoVEs deepen their engagement with the labour market and cooperate with other skills providers to form part of a comprehensive, inclusive, high-quality network? How can the design and development of CoVEs be linked to other elements of human capital development strategy, for example the development of lifelong learning or the emergence of smart specialisation? This study researches CoVEs as an international phenomenon but also through their local specificities with the aim of understanding better the different missions and functions and the reasons that have led to their development. Inevitably, the absence of a single all-inclusive definition of CoVEs has often raised questions about the status of the centres that were identified and examined. At this point in time the definition of the term and its scope and value are all up for debate. This study explores different perceptions and reveals some of the differences in policy, rhetoric and practice that underpin them. This paper is intended to offer a different perspective on vocational excellence. It aims to help with understanding of the phenomenon and its links with vocational education and training (VET). Furthermore, it focuses on countries outside the EU with the aim of bringing forward perceptions of vocational excellence that are not yet fully realised in terms of partnerships and cooperation. In this respect, this paper is ultimately aimed at educationists, VET experts and, where appropriate, policy-makers.

Published
2020

42. Schlussbetrachtungen

Author

Thomas, Stefan, Flick, Uwe, Series Editor, Littig, Beate, Series Editor, Lueders, Christian, Series Editor, Poferl, Angelika, Series Editor, Reichertz, Jo, Series Editor, and Thomas, Stefan

Published
2019
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43. Ethnografische Datenauswertung

Author

Thomas, Stefan, Flick, Uwe, Series Editor, Littig, Beate, Series Editor, Lueders, Christian, Series Editor, Poferl, Angelika, Series Editor, Reichertz, Jo, Series Editor, and Thomas, Stefan

Published
2019
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44. Theoretische Hintergründe

Author

Thomas, Stefan, Flick, Uwe, Series Editor, Littig, Beate, Series Editor, Lueders, Christian, Series Editor, Poferl, Angelika, Series Editor, Reichertz, Jo, Series Editor, and Thomas, Stefan

Published
2019
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45. Ethnografische Entdeckungsreise

Author

Thomas, Stefan, Flick, Uwe, Series Editor, Littig, Beate, Series Editor, Lueders, Christian, Series Editor, Poferl, Angelika, Series Editor, Reichertz, Jo, Series Editor, and Thomas, Stefan

Published
2019
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46. Schreiben des ethnografischen Berichts

Author

Thomas, Stefan, Flick, Uwe, Series Editor, Littig, Beate, Series Editor, Lueders, Christian, Series Editor, Poferl, Angelika, Series Editor, Reichertz, Jo, Series Editor, and Thomas, Stefan

Published
2019
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47. Beobachtungsprotokolle und Feldnotizen

Author

Thomas, Stefan, Flick, Uwe, Series Editor, Littig, Beate, Series Editor, Lueders, Christian, Series Editor, Poferl, Angelika, Series Editor, Reichertz, Jo, Series Editor, and Thomas, Stefan

Published
2019
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48. Fragestellung und Forschungsdesign

Author

Thomas, Stefan, Flick, Uwe, Series Editor, Littig, Beate, Series Editor, Lueders, Christian, Series Editor, Poferl, Angelika, Series Editor, Reichertz, Jo, Series Editor, and Thomas, Stefan

Published
2019
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