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9 results on '"Thomas, Tima"'

2. Abstract LB025: First disclosure of AZD5335, a TOP1i-ADC targeting low and high FRα-expressing ovarian cancer with superior preclinical activity vs FRα-MTI ADC

Author

Gymnopoulos, Marco, primary, Thomas, Tima, additional, Gasper, Diana, additional, Anderton, Judith, additional, Tammali, Ravinder, additional, Rosfjord, Ed, additional, Durham, Nick, additional, Ward, Chris, additional, Myers, Claire, additional, Wang, Jixin, additional, Zhong, Wenyan, additional, Christ, Simon, additional, Meinecke, Lina, additional, Nekolla, Katharina, additional, Monasor, Laura Sebastian, additional, Dodd, Roger, additional, Patel, Neki, additional, Albertella, Mark, additional, Zeron-Medina, Jorge, additional, Fraenkel, Paula, additional, and Sapra, Puja, additional

Published
2023
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9. Targeted delivery of nano-PTX to the brain tumor-associated macrophages.

Author

Zou L, Tao Y, Payne G, Do L, Thomas T, Rodriguez J, and Dou H

Subjects
Animals, Antineoplastic Agents chemistry, Antineoplastic Agents metabolism, Antineoplastic Agents toxicity, Blood-Brain Barrier metabolism, Brain Neoplasms metabolism, Brain Neoplasms pathology, Capillary Permeability, Cell Line, Tumor, Coculture Techniques, Delayed-Action Preparations, Dose-Response Relationship, Drug, Drug Compounding, Drug Design, Glioma metabolism, Glioma pathology, Glycoproteins metabolism, Humans, Lactic Acid chemistry, Ligands, Lipids chemistry, Macrophages metabolism, Macrophages pathology, Male, Mice, Inbred BALB C, Mice, SCID, Neurons metabolism, Paclitaxel chemistry, Paclitaxel metabolism, Paclitaxel toxicity, Peptide Fragments metabolism, Polyglycolic Acid chemistry, Polylactic Acid-Polyglycolic Acid Copolymer, Time Factors, Tissue Distribution, Viral Proteins metabolism, Xenograft Model Antitumor Assays, Antineoplastic Agents administration & dosage, Brain Neoplasms drug therapy, Drug Carriers, Glioma drug therapy, Macrophages drug effects, Nanoparticles, Paclitaxel administration & dosage
Abstract

Nanoparticles containing mixed lipid monolayer shell, biodegradable polymer core and rabies virus glycoprotein (RVG) peptide as brain targeting ligand, were developed for brain targeted delivery of paclitaxel (PTX) to treat malignant glioma. RVG conjugated PTX loaded NPs (RVG-PTX-NPs) had the desirable size (~140 nm), narrow size distribution and spherical shape. RVG-PTX-NPs showed poor uptake by neurons and selective targeting to the brain tumor associated macrophages (TAMs) with controlled release and tumor specific toxicity. In vivo studies revealed that RVG-PTX-NPs were significant to cross the blood-brain barrier (BBB) and had specific targeting to the brain. Most importantly, RVG-PTX-NPs showed effectiveness for anti-glioma therapy on human glioma of mice model. We concluded that RVG-PTX-NPs provided an effective approach for brain-TAMs targeted delivery for the treatment of glioma.

Published
2017
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