44 results on '"Thomas R. Lee"'
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2. The Corpus and the Critics
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Thomas R. Lee and Stephen C. Mouritsen
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Statutory interpretation ,Notice ,Corpus linguistics ,Interpretation (philosophy) ,Falsifiability ,Sociology ,Meaning (linguistics) ,Supreme court ,Test (assessment) ,Epistemology - Abstract
Most any approach to interpretation of the language of law begins with a search for ordinary meaning. Increasingly, judges, scholars, and practitioners are highlighting shortcomings in our means for assessing such meaning. With this in mind, we have proposed the use of the tools of corpus linguistics to take up the task. Our proposals have gained traction but have also seen significant pushback. The search for ordinary meaning poses a series of questions that are amenable to evaluation and analysis using evidence of language usage. And we have proposed to use the tools of corpus linguistics—tools for assessing patterns of language usage in large databases of naturally occurring language—to introduce transparent, falsifiable evidence on the questions at stake. Our critics raise a series of challenges, asserting that our methods test the wrong language community, pose notice problems, are inaccurate measures, and rest on certain fallacies. We show that the criticisms are largely in error and ultimately highlight some of the main selling points of our proposed methods. We do so in reference to two canonical Supreme Court cases that have been discussed in the literature in this field (Muscarello v. United States and Taniguchi v. Kan Pacific Saipan, Ltd.) and also a more recent case (Mont v. United States). In analyzing these cases (particularly the most recent one), we also outline a framework for some proposed refinements to the methods we have advocated previously.
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- 2020
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3. After the Honeymoon: The Evolution of Problem Issues in Utah LDS Marriages
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Daniel Moen, J. Wade Stewart, Thomas R. Lee, Victor W. Harris, and Kay Bradford
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Marital satisfaction ,Affection ,media_common.quotation_subject ,Honeymoon ,Psychology ,Social psychology ,Social Sciences (miscellaneous) ,media_common - Abstract
The main objective of this study was to extend previous research in the area of longitudinal marital satisfaction by examining how marital issues, including decision-making, activities, affection, conflict, financial matters, stability, and values, changed over the first 5 years of marriage for 242 Utah, Latter-Day-Saint individuals. In addition, this study examined whether change occurs differently for husbands versus wives and for at-risk individuals versus non-risk individuals. The results showed that four marital issues worsened over time (activities, affection, conflict, and stability). Two of the six subscales (activities and affection) were found to differ significantly by gender. In addition, four subscales were significantly different for at-risk couples when compared with non-risk couples (decision-making, activities, conflict, and stability). Limitations and recommendations are discussed.
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- 2015
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4. Data-Driven Originalism
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Thomas R. Lee and James Cleith Phillips
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Statute ,Originalism ,Original meaning ,History ,Corpus linguistics ,Constitution ,media_common.quotation_subject ,American English ,Solum ,Linguistics ,Transparency (linguistic) ,media_common - Abstract
The threshold question for all originalist methodologies concerns the original communicative content of the words of the Constitution. For too long this inquiry has been pursued through tools that are ill-suited to the task. Dictionaries generally just define individual words; they don’t typically define phrases or allow for the consideration of broader linguistic context. And while dictionaries can provide a list of possible senses, they can’t tell us which sense is the most ordinary (or common). Founding-era dictionaries, moreover, were generally the work of one individual, tended to plagiarize each other, and relied on famous, often dated examples of English usage (from Shakespeare or the King James Bible). Originalists have also turned to examples of usage in founding-era documents. This approach can address some of the shortcomings of dictionaries; a careful inquiry into sample sentences from founding-era literature can consider a wide range of semantic context. Yet even here the standard inquiry falls short. Originalists tend to turn only to certain sources, such as the Federalist Papers or the records of the state constitutional conventions, and those sources may not fully reflect how ordinary users of English of the day would have understood the Constitution (or at least have used language). Second, the number of founding-era documents relied on is often rather small, especially for generalizing about an entire country (or profession, in the case of lawyers). This opens originalists up to criticisms of cherry-picking, and even if that is not the case, sample sizes are just too small to confidently answer originalist questions. But all is not lost. Big data, and the tools of linguists, have the potential to bring greater rigor and transparency to the practice of originalism. This article will explore the application of corpus linguistic methodology to aid originalism’s inquiry into the original communicative content of the Constitution. We propose to improve this inquiry by use of a newly released corpus (or database) of founding-era texts: the beta version of the Corpus of Founding-Era American English. The initial beta version will contain approximately 150 million words, derived from the Evans Early American Imprint Series (books, pamphlets and broadsides by all types of Americans on all types of subjects), the National Archives Founders Online Project (the papers of Washington, Franklin, Adams, Jefferson, Madison, and Hamilton, including correspondence to them), and Hein Online’s Legal Database (cases, statutes, legislative debates, etc.). The paper will showcase how typical tools of a corpus—concordance lines, collocation, clusters (or n-grams), and frequency data—can aid in the search for original communicative content. We will also show how corpus data can help determine whether a word or phrase in question is best thought of as an ordinary one or a legal term of art. To showcase corpus linguistic methodology, the paper will analyze important clauses in the Constitution that have generated litigation and controversy over the years (commerce, public use, and natural born) and another whose original meaning has been presumed to be clear (domestic violence). We propose best practices, and also discuss the limitations of corpus linguistic methodology for originalism. Larry Solum has predicted that “corpus linguistics will revolutionize statutory and constitutional interpretation.”* Our paper seeks to chart out the first steps of that revolution so that others may follow.
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- 2018
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5. Father Involvement, Father–Child Relationship Quality, and Satisfaction With Family Work
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David Schramm, Adam M. Galovan, Thomas R. Lee, and Erin K. Holmes
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Post hoc ,Child rearing ,media_common.quotation_subject ,social sciences ,Family work ,Developmental psychology ,Family systems theory ,Spouse ,Perception ,behavior and behavior mechanisms ,population characteristics ,Quality (business) ,Psychology ,Social psychology ,Social Sciences (miscellaneous) ,Division of labour ,media_common - Abstract
Using family systems theory and an actor–partner interdependence model, we examine the influence of the division of family work (including fathers’ participation in child rearing) on father–child relationship quality, satisfaction with the family work division, and marital quality. The strongest effect on both spouses’ marital quality is wives’ perception of father–child relationship quality. Following this, wives’ perceptions of father participation in child rearing are positively associated with both spouses’ reports of marital quality. Furthermore, both husbands and wives report higher marital quality when they are more satisfied with the division of labor. When wives report their husbands have greater responsibility for family tasks, both spouses report higher satisfaction with the division of labor. Post hoc analyses revealed that wives are more satisfied with the division of labor when they work with their spouse rather than alone. All findings support a systemic relational orientation to family work, the division of roles, and relationship quality.
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- 2013
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6. Marital Quality, Context, and Interaction: A Comparison of Those Currently Receiving Government Assistance with Those Who Are Not
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Victor W. Harris, Thomas R. Lee, David Schramm, and James P. Marshall
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Religiosity ,Government ,Age at first marriage ,Contextual variable ,media_common.quotation_subject ,Criticism ,Context (language use) ,Quality (business) ,Negativity effect ,Psychology ,Social Sciences (miscellaneous) ,Clinical psychology ,media_common - Abstract
In this study the marital quality of respondents who were currently receiving government assistance was compared with those who were not. Contextual variables (e.g., gender, age, age at first marriage, religiosity, education, etc.) and interactional variables (i.e., escalating negativity, criticism, negative interpretation, withdrawal) were measured as potential correlates with marital quality. Results indicated that those who received government assistance differed significantly from those who did not on all six indicators of marital quality that were measured and on 8 of 11 contextual variables measured. Findings from this study will help policymakers, therapists, and other helping professionals gain an increased awareness of the needs of these two distinct populations and how to target educational programs to best address those needs.
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- 2012
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7. Religiosity, Homogamy, and Marital Adjustment
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David Schramm, Victor W. Harris, Thomas R. Lee, and James P. Marshall
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Religiosity ,Marital satisfaction ,Family structure ,Remarriage ,media_common.quotation_subject ,Wife ,Statistical analysis ,Religious denomination ,Psychology ,Social psychology ,Social Sciences (miscellaneous) ,Demography ,media_common - Abstract
This article explores the relationship between religiosity, denominational homogamy, religiosity homogamy, and marital adjustment. Using a statewide sample of spouses in first marriages ( N = 1,394) and remarriages ( N = 601), the authors find that within-group differences in religiosity, denominational homogamy, and religiosity homogamy are not as prevalent for spouses in remarriages. Overall, husbands and wives in first marriages who are very religious have significantly higher marital adjustment scores than spouses who are less religious. Similarly, husbands and wives in first marriages who share the same religious denomination report higher marital adjustment scores than spouses who report different denominations. For spouses in both first marriages and remarriages, those who report that they are “both religious” have higher marital adjustment scores than spouses where both partners are not religious, or where only the wife is religious. Possible reasons for the within-group similarities and differences are explored, particularly for spouses in remarriages.
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- 2011
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8. Marital Commitment and Religiosity in a Religiously Homogenous Population
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Linda Skogrand, Scot M. Allgood, Sharon Harris, and Thomas R. Lee
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education.field_of_study ,Organized religion ,Religious values ,media_common.quotation_subject ,Population ,Attendance ,Religiosity ,Spouse ,Institution ,education ,Psychology ,Constraint (mathematics) ,Social psychology ,Social Sciences (miscellaneous) ,media_common - Abstract
Statewide surveys of marriage and divorce in Oklahoma and Utah point to the need to better understand the importance of commitment to marriage in a religiously homogenous population. The components of commitment—to their spouse, to marriage as an institution, and constraints to stay in the relationship—were explored in relation to religious values and attendance in an organized religion. Results indicate significant associations between these variables, with higher levels of values and attendance having a positive relationship with commitment to spouse and marriage. Constraint commitment was associated with lower religious values and attendance.
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- 2008
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9. Graduate Distance Education in Family Relations: A Case Study
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Thomas R. Lee and Kathleen W. Piercy
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Medical education ,Academic year ,Higher education ,business.industry ,Distance education ,Professional development ,Attendance ,Education ,ComputingMilieux_COMPUTERSANDEDUCATION ,Developmental and Educational Psychology ,Mathematics education ,Medicine ,Comparative education ,business ,Social Sciences (miscellaneous) ,Strengths and weaknesses ,Career development - Abstract
This paper discusses graduate distance education in family relations and related disciplines, using a case study approach. Challenges that occur in distance graduate programs are outlined and illustrated by examination of a new master's degree program in Family and Human Development. The program delivers courses by satellite broadcast and interactive television and requires two on-campus meetings. Graduates gave the overall program high marks, with instructor/instruction factors most important in their ratings of most and least favorite courses. We examine the implications of various strengths and weaknesses of the program for graduate program development and teaching pedagogy and offer suggestions to address logistical and pedagogical challenges of distance education in family relations. Key Words: education, family relations, professional development, teaching pedagogy. Introduction and Literature Review Although many family studies programs have a rich history of graduate education, little has been written about graduate program development and teaching pedagogy. Most discussion of graduate education in family relations has focused on career development issues, such as preparing graduate students to teach (Blaisure & Walcheski, 1997; Lamke, 1998), mentoring graduate student research (Benson & Piercy, 1997), and the preparation of graduates for the job market (Futris et al., 1999). There is a need to increase our understanding of graduate education in human development and family relations, especially as ways of delivering such education are changing. The Council of Graduate Schools (1998) recently noted that because of changing needs of professions and employers, the master's degree had undergone significant refinement in the latter half of the 20th century. One result of these changes has been an increased number of applied master's degree programs in a variety of disciplines, including family studies (Hans, 2002). Another recent focus of higher education has been the offering of advanced degrees for adults living at a distance from major campuses or with schedules that do not permit on-campus class attendance. Courses, certificates, and degree programs are delivered online through the Internet, through use of videocassettes, or via interactive television. The U.S. Department of Education (2003) reported that during the 2000-2001 academic year, 56% (2,320) of all 2 and 4 year Title IV-eligible, degree-granting institutions offered distance education courses. By 1995, 7,500 graduate, technology-based distance education courses were offered by institutions of higher education (Council of Graduate Schools, 1998). Confluences of demographic trends and technological advances have increased the numbers of advanced degrees offered at a distance. For more than a decade, real growth in graduate education has come from "nontraditional" students who are most likely to be female, part-time, and older in age. These students often gauge the value of their education in terms of securing jobs and promotions (Council of Graduate Schools, 1998). Thus, they look for applied programs that offer the flexibility of part-time study at times and locations that are most convenient to them. These new learners increasingly are choosing technology-based distance education programs (Council of Graduate Schools). Competition for the new "majority" student challenges traditional universities, which must contend with the offerings of comparable institutions and virtual universities, as well as other providers (i.e., University of Phoenix). In a special issue on distance education published in Family Science Review, Day and Baugher (1999) argued that degree programs delivered via distance education would likely increase in the future because of shrinking state appropriations for higher education and increased demand from the public. Several applied master's degree programs now are delivered by means of distance education. …
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- 2006
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10. After 'I Do': The Newlywed Transition
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James P. Marshall, David Schramm, Thomas R. Lee, and V. William Harris
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Marital satisfaction ,Affection ,media_common.quotation_subject ,Marital status ,Newlywed ,Psychology ,Family life education ,Social Sciences (miscellaneous) ,Clinical psychology ,Demography ,media_common - Abstract
Marital satisfaction, marital adjustment, and problem areas experienced during the early months of marriage were examined using a sample of 1,010 newlywed husbands and wives. Results revealed that between 8% and 14% percent of newlyweds already scored in the distressed range on measures of marital satisfaction and adjustment, respectively. For both husbands and wives, the most problematic areas in the early months of marriage were balancing employment and marriage and debt brought into marriage. However, protective factors in the marriage, including respect, appreciation, commitment, mutual affection, and trust, were the strongest predictors of marital satisfaction and adjustment. Implications for future research and family life education are proposed.
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- 2005
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11. The Census and the Overseas Population
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Thomas R. Lee and Lara J. Wolfson
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Economic growth ,Government ,education.field_of_study ,Peacetime ,Geography ,Statutory law ,Population ,Mandate ,House of Representatives ,Census ,education ,Law ,American Community Survey - Abstract
343 BY CONSTITUTIONAL AND STATUTORY MANDATE, a census of “population” of the “whole number of persons in each state” must be conducted every 10 years.1 The U.S. Census Bureau invests enormous resources in complying with its decennial duty to enumerate the population of the persons that currently reside within one of the United States.2 This “domestic population” is counted by an initial massmailing of a census form sent to each address on a comprehensive master address file, followed by as many as six follow-up visits to addresses that do not respond. The 2000 domestic count has aptly been described as the “largest peacetime mobilization” of personnel undertaken by the federal government.3 It stands in stark contrast to the approach the Census Bureau historically has taken with regard to the “overseas population”—American citizens temporarily living outside of the United States on census day. For most of this nation’s history, the overseas population has been excluded entirely from the census (at least from the count relevant to the constitutional purpose of apportioning representation in the House of Representatives). The Census Bureau enumerated a subset of the overseas population in each of the past two censuses (1990 and 2000), but such attempts were directed only at those American citizens who happened to be employed by the federal government. The Census Bureau’s reluctance to enumerate the overseas population is certainly understandable. The domestic census itself is a daunting enough task; the prospect of extending the Bureau’s mailing efforts and follow-up visits to every far-flung place throughout the world where an American might be found is almost unimaginable. The question, however, is whether the Bureau acted lawfully (and wisely) in addressing this logistical barrier in the way that it did in the past two censuses—by counting only a small segment of the overseas population and ignoring the rest, instead of continuing the historical approach of limiting the census to the domestic population, or employing some alternative method of counting substantially all of the overseas population. This article addresses both legal and policy objections to the partial count of the overseas population conducted by the Census Bureau in 1990 and 2000. After reviewing the history of
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- 2003
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12. Utah's Census Battles: The inside Story
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Lara J. Wolfson and Thomas R. Lee
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Geography ,General Medicine ,Census ,Archaeology - Published
- 2003
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13. The Family Profile II: A Self-Scored, Brief Family Assessment Tool
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Ivan F. Beutler, Wesley S. Burr, Thomas R. Lee, Joseph A. Olsen, Floyd W. Yorgason, and H. Brent Harker
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Kindness ,business.industry ,media_common.quotation_subject ,Family functioning ,05 social sciences ,050109 social psychology ,Sample (statistics) ,Plot (graphics) ,Developmental psychology ,Financial management ,School performance ,050902 family studies ,0501 psychology and cognitive sciences ,Quality (business) ,0509 other social sciences ,Substance use ,business ,Psychology ,Social psychology ,General Psychology ,media_common - Abstract
The Family Profile is a self-administered and easily interpreted measure of family functioning. Family members score and plot their results to create a graphical profile of their family's relationship strengths. The ability to graph their responses gives families immediate feedback and an intuitive grasp of their relationship strengths and opportunities for improving family relationships. Successfully used for 7 years in the USA and Canada, the Family Profile has now been revised. Using a national sample of over 1,800 college students, the measure was revised to include 12 scales measuring dimensions of family functioning such as kindness, unkindness, communication, and financial management. Regression analyses indicated that these scales significantly predicted family reladonship quality, school performance, substance use, and family conflict. The Family Profile II provides practitioners a measure that is easily scored and interpreted.
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- 1997
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14. Abercrombie Unveiled: A Theoretical and Empirical Analysis of Trademark Distinctiveness
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Thomas R. Lee
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Trademark ,Empirical research ,media_common.quotation_subject ,Ignorance ,Optimal distinctiveness theory ,Arbitrariness ,Objectivity (science) ,Psychology ,Social psychology ,Consumer behaviour ,media_common ,Epistemology ,Skepticism - Abstract
The word mark taxonomy established in Abercrombie is a longstanding tenet of doctrinal orthodoxy. Lawmakers have so oft restated the Abercrombie classes and so consistently rehearsed the theoretical grounds that undergird them that it no longer occurs to us to question their premises. But there are good reasons - both pragmatic and theoretical ones - to question the Abercrombie system. At the practical level, it should be noted that the perceived objectivity and predictability of the Abercrombie classification system are a mirage. The law is incessantly and understandably searching for fixed lodestars to guide and cabin judicial and administrative decision-making. Abercrombie offers the appearance of such a lodestar at the threshold stage of evaluating trademark distinctiveness - in the form of a five-level classification system that channels the availability, timing, and degree of trademark protection. Yet although some of those classifications turn on bright-line, objective criteria, that cannot be said of the classification that matters most - of the line between the "suggestive" and the "merely descriptive." Courts and commentators have long lamented the subjectivity and arbitrariness of sorting word marks between these two classifications, and that pragmatic problem gives substantial grounds for an agnostic skepticism toward the Abercrombie orthodoxy. In terms of theory, trademark law is ripe for a thorough reevaluation in the light of the tools employed in the scholarly study of consumer psychology and behavior. The law's reflexive restatement of the grounds for its treatment of "merely descriptive" word marks - that they are unlikely to be perceived by consumers as indicators of source - is a glaring reminder that the law in this field turns on questions well beyond the competence of those trained in the art of legal analysis and interpretation. Where (as here) the law depends on answers to questions that are the focus of an entire field of scholarly study, we cannot afford to proceed in arrogant ignorance of the insights offered by such a field of expertise. In this case, the field of consumer psychology has much to offer the law of trademark distinctiveness. Perceptual schema theory provides ample grounds for doubting the law's myopic focus on the semantic meaning of a descriptive word mark. A consumer who encounters a descriptive word mark in its "trademark use" context may well perceive it as a source indicator on the basis of the mark's non-linguistic cues or indicators of meaning. Those non-linguistic indicators will be provided in large part by the consumer's perceptual models and expectations of a typical brand or source indicator in commercial context. If the descriptive word mark is presented in a spatial layout, size, and placement that matches the consumer's general schematic mental model of what a brand looks like, the word may be perceived as a source indicator even if its semantic meaning is "merely descriptive." Our theoretical model provides grounds for skepticism of Abercrombie; our empirical study completely undermines it. In other words, perceptual schema theory offers a reason to wonder whether and to what extent non-linguistic signs may overwhelm the linguistic signs credited by the law-to consider the possibility that even "merely descriptive" word marks might nonetheless be perceived as source indicators when the non-linguistic markers that accompany their trademark use overshadow their semantic meaning. But empirical analysis can - and does - provide concrete answers to the question of the relative impact of the linguistic and non-linguistic indicators of distinctiveness. Our empirical studies show that Abercrombie rests on an erroneous assumption about the predominant impact of semantic word meaning. So long as the word is used in an "average" trademark use context, a word mark's semantic meaning is shown to be overshadowed by the non-linguistic, contextual markers that establish its distinctiveness as a source indicator.
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- 2008
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15. Trademarks, Consumer Psychology, and the Sophisticated Consumer
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Thomas R. Lee, Glenn Christensen, and Eric DeRosia
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Trademark ,Consumer confusion ,business.industry ,media_common.quotation_subject ,Common law ,ComputingMilieux_LEGALASPECTSOFCOMPUTING ,Public relations ,Intellectual property ,Scholarship ,Political science ,business ,Trademark infringement ,Sophistication ,Consumer behaviour ,Law and economics ,media_common - Abstract
The degree of consumer "sophistication" is an important factor in the judicial evaluation of the legal standard of trademark infringement: the likelihood of consumer confusion. Yet although the law in this field is premised on assumptions about consumer psychology, the case law has developed in ignorance of an important body of scholarship devoted to that very subject. This article seeks to remedy this disconnect by drawing on scholarship in the field of consumer psychology to develop a model of consumer cognition. The consumer psychology literature suggests a much richer conception of sophistication than is currently acknowledged by the courts. The case law is dominated by an ad hoc treatment of sophistication that has generated numerous conflicts and inconsistencies in the judicial evaluation of trademark infringement. Our model provides a comprehensive framework for understanding the proper role of consumer sophistication in trademark infringement litigation and for resolving many of the conflicts in the case law.
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- 2007
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16. Equipping Young Pastors Who Serve In Traditional Congregations With Transformational Leadership Skills In Western North Carolina At The Buncombe Baptist Resource Center, Asheville, North Carolina
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Thomas R. LEE
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- 2006
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17. THE FAMILY PROFILE II: A SELF-SCORED, BRIEF FAMILY ASSESSMENT TOOL
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THOMAS R. LEE
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General Psychology - Published
- 1997
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18. Impact Evaluation of Facts & Feelings: A Home-Based Video Sex Education Curriculum
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Brent C. Miller, Maria C. Norton, Glen O. Jenson, Thomas R. Lee, Cynthia Christopherson, and Pamela K. King
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Medical education ,media_common.quotation_subject ,Impact evaluation ,Primary education ,Human sexuality ,Sex education ,Home based ,Education ,Sex education curriculum ,Feeling ,Pedagogy ,Developmental and Educational Psychology ,Psychology ,Social Sciences (miscellaneous) ,media_common - Published
- 1993
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19. Sibling Relationships in Adulthood: Contact Patterns and Motivations
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Thomas R. Lee, Jay A. Mancini, and Joseph W. Maxwell
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Adult development ,Sister ,Sibling relationship ,Brother ,Developmental psychology ,Interpersonal relationship ,Arts and Humanities (miscellaneous) ,Anthropology ,Respondent ,Religious organization ,Sibling ,Psychology ,Social psychology ,Social Sciences (miscellaneous) - Abstract
context of relationship quality variables (emotional closeness, sibling responsibility expectations, and conflict), and individual and family characteristics (sibling age differences, number of siblings, geographic proximity, sex of respondent, sex composition of sibling pair, and whether the respondent has coresident children). Through a two-stage systematic sampling procedure of telephone and mail surveys, a sample of 313 adults aged 25 years or older with living siblings was obtained from a southwest Virginia urban area. The proportion of variance explained by the predictors were significant and substantial for each criterion (dependent variable R2 s of. 65, .37, and .69). Emotional closeness, sibling responsibility expectations, and geographic proximity were most important in explaining dimensions of sibling interaction. These reflect the significance of internal states, cultural expectations and family norms, and practical opportunities for interaction, in matters concerning aspects of the sibling relationship. The sibling role potentially has the longest duration of any human relationship (Cicirelli, 1980b). Over 80% of American children grow up in a family that includes siblings (Mussen, Conger, and Kagan, 1974), and in late adulthood 79% have living siblings (Harris and Associates, 1975). There are cultural expectations that the sibling relationship should be more emotionally close, meaningful, and enduring than other interpersonal associations, as evidenced by denoting a close friend as "like a brother" or "like a sister." In religious organizations, fraternal orders, or the military, the titles "brother" or "sister" connote solidarity and equality (Pollak, 1967). Liebow (1967) documented that impoverished urban blacks, lacking family ties, construct such associations by "going for brothers" as an attempt to create more stable, dependable relationships. Despite the prevalence of the sibling role in adulthood, and the expectations that sibling relationships be especially stable and emotionally close, the family relationships of siblings in adulthood have received little research attention. Research on family relationships across adulthood typically focuses upon the marital or parent-child pair and much less so upon the role that other kin may play in adult development. Most research on siblings has dealt with childhood or later life. For several decades, social and behavioral scientists have lamented the lack of research on adult sibling relationships (Cicirelli, 1980b; Goetting, 1986; Irish, 1965; Schvaneveldt and Ihinger, 1979; Streib and Beck, 1980). In conDepartment of Family and Human Development, Utah State University, UMC 29, Logan, UT 84322-2905.
- Published
- 1990
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20. The Standing of Qui Tam Relators under the False Claims Act
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Thomas R. Lee
- Subjects
Qui tam ,False Claims Act ,Operations management ,Psychology ,Law ,Law and economics - Published
- 1990
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21. Nutritional Understanding of Preschool Children Taught in the Home or a Child Development Laboratory
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Jay D. Schvaneveldt, Anne W. Sorenson, and Thomas R. Lee
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Cultural Studies ,Research design ,Medical education ,medicine.medical_specialty ,Sociology and Political Science ,business.industry ,Experimental model ,Nutritional quality ,Child development ,Test (assessment) ,Nutrient density ,Physical therapy ,Medicine ,Health education ,business ,Curriculum - Abstract
The main conclusion of this research is that preschool children are capable of learning basic concepts of nutrition, including nutritive value, nutrient function, and the impact of nutrition on health. The research design was a before and after experimental model, with 20 children taught nutritional concepts in a child de velopment lab, 20 children taught at home by parents, and 20 children serving as a control group and receiving no instruction. The curriculum was based on nutrient density and used the Index of Nutritional Quality (INQ). Mean compar isons of pre- and posttest scores on a 12-item nutrition test were significant with both the Child Lab and home-taught groups.
- Published
- 1984
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22. A fast charge digitizer and digital data acquisition system for measurement of time varying radiation fields
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Roger H. Schneider, Thomas R. Lee, and John L. Wyatt
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Physics ,Comparator ,business.industry ,Analogue switch ,Electrical engineering ,General Medicine ,law.invention ,Comparator applications ,Capacitor ,Multivibrator ,law ,Schmitt trigger ,Integrator ,business ,Voltage - Abstract
A radiation measuring instrument including a fast charge digitizer and a digital data acquisition system has been developed. The fast charge digitizer includes a charge integrator connected to a conventional ionization chamber which generates an output current in proportion to ionizing radiation exposure rate. The charge integrator has an output connected to a comparator which is switched from a high state to a low state when the output of the integrator goes above the comparator threshold. The comparator output is connected to a bistable multivibrator consisting of two non-retriggerable one shot multivibrators connected in a feedback configuration. As long as the comparator output is in the low state, the bistable multivibrator generates a train of pluses which are fed back through an analog switch and a high megohm resistance to the input of the integrator. This feedback is negative and has the effect of removing the charge from the integrating capacitor, thus causing the integrator output eventually to drop below the comparator threshold. When this occurs the comparator output returns to the high state and the bistable multivibrator ceases to generate output pulses. An output terminal is connected between the bistable multivibrator and the analog switch and feeds a train of pulses proportional to the amount of charge generated by the multivibrator output voltage and the high megohm resistance to a counter connected to a random access memory device. The output pulses are counted for a predetermined time and then stored in one of the data locations of the random access memory device. The counter is then reset and a further predetermined sample period is counted. This continues until all of the locations in the random access memory device are filled and then the data is read from the random access memory device.
- Published
- 1975
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23. The South Looks at Its Elementary Schools.
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Morrison, Roy W. and Thomas, R. Lee
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ELEMENTARY schools ,EDUCATION ,SCHOOL enrollment ,EDUCATIONAL programs ,CONFERENCES & conventions - Abstract
This article presents information on how educators in the Southern Regions of the United States are trying to provide better educational programs for boys and girls. The federal census shows that approximately one-half of the nation's functionally illiterate adults live in the Southern Region. Comparison of elementary school enrollment, attendance, and retardation figures clearly reveals the low quality of educational opportunity which is provided in this group of states. These and other such facts prompted the Southern States Work-Conference to select as a major project a study of elementary education. The study was initiated in 1945 with the appointment of a regional steering committee to develop plans and promote the study. The purpose of the study was to increase the effectiveness of elementary education as an integral part of the total school program in the Southern Region by encouraging each state to face squarely the pertinent problems at this educational level and to formulate a program of action to effectuate necessary improvements.
- Published
- 1947
24. It Happened in Dog Creek.
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Hall, Mary and Thomas, R. Lee
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LEARNING - Abstract
Presents the short story "It Happened in Dog Creek," by Mary Hall and R. Lee Thomas.
- Published
- 1945
25. Congenital Chloridorrhœa
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Thomas R Lee, J K Lloyd, and J T Harries
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- 1973
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26. Developing Family Relationship Skills to Prevent Substance Abuse among High-Risk Youth
- Author
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H. Wallace Goddard and Thomas R. Lee
- Subjects
Family relationship ,High-risk youth ,media_common.quotation_subject ,medicine.disease ,Skill development ,Family life education ,Education ,Neglect ,Developmental psychology ,Substance abuse ,Adolescent substance ,Developmental and Educational Psychology ,medicine ,Empowerment ,Psychology ,Social Sciences (miscellaneous) ,Clinical psychology ,media_common - Abstract
Although family factors are increasingly recognized in the problem of adolescent substance abuse, prevention programs continue to neglect the family as an important component of prevention programs. Family Connections, a family skills building program to prevent adolescent substance abuse, is described. The importance of basing family life education prevention programs on an empowerment and family strengths approach which is adapted to the unique situation of each family is discussed.
- Published
- 1989
- Full Text
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27. Lee's 'Studies in Sirach'
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Thomas R. Lee and Benjamin G. Wright
- Subjects
Cultural Studies ,History ,Religious studies - Published
- 1989
- Full Text
- View/download PDF
28. Locus of Control and Premarital Sexual Behaviors
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Jay A. Mancini and Thomas R. Lee
- Subjects
Locus of control ,Sexual behavior ,Psychology ,General Psychology ,Developmental psychology - Published
- 1981
- Full Text
- View/download PDF
29. Forgotten Children: Parent-Child Relations from 1500 to 1900
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Linda A. Pollock and Thomas R. Lee
- Subjects
Developmental and Educational Psychology ,Social Sciences (miscellaneous) ,Education - Published
- 1986
- Full Text
- View/download PDF
30. TENNESSEE EXTENDS SUPERVISORY SERVICE.
- Author
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Thomas, R. Lee
- Subjects
TEACHER exchange programs ,VISITING professors ,SCHOOL supervisors ,SCHOOL social work ,ELEMENTARY school teachers ,ELEMENTARY school teaching ,ELEMENTARY schools ,PUBLIC institutions - Abstract
The article reports on the supervisory service for teachers who have instructional problems, offered by the government in Tennessee. Along with the supervisory service for the elementary schools, Commissioner Duggan agreed to give permission for additional teaching positions, called visiting teachers, to counties that were involved in the State Equalization Funds. The visiting teachers will perform the same duties and responsibilities related to those county elementary school supervisors. There are fifty-five visiting teachers employed in 51 of the 95 counties of the state of Tennessee, in the year 1944.
- Published
- 1944
31. Antibiotic resistance in acute postoperative endophthalmitis.
- Author
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Holland EJ, McDonald MB, Parekh JG, and Sheppard JD
- Subjects
- Acute Disease, Endophthalmitis microbiology, Eye Infections, Bacterial microbiology, Humans, Surgical Wound Infection microbiology, Anti-Bacterial Agents therapeutic use, Drug Resistance, Microbial, Endophthalmitis drug therapy, Eye Infections, Bacterial drug therapy, Surgical Wound Infection drug therapy
- Abstract
Acute postoperative endophthalmitis (APE) is a serious, although infrequent, complication of eye surgery that can result in significant morbidity and costs. This review addresses APE risk factors, associated bacterial pathogens, antibiotic resistance, and prevention., (Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
32. Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial.
- Author
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Sheppard JD Jr, Singh R, McClellan AJ, Weikert MP, Scoper SV, Joly TJ, Whitley WO, Kakkar E, and Pflugfelder SC
- Subjects
- Adult, Aged, Aged, 80 and over, CD11c Antigen metabolism, Conjunctiva physiology, Corneal Topography, Double-Blind Method, Fatty Acids, Omega-3 adverse effects, Female, Fluorescein chemistry, HLA-DR Antigens metabolism, Humans, Keratoconjunctivitis Sicca metabolism, Lissamine Green Dyes chemistry, Male, Middle Aged, Ophthalmic Solutions, Patient Compliance, Staining and Labeling methods, Tears physiology, Visual Acuity physiology, gamma-Linolenic Acid adverse effects, Fatty Acids, Omega-3 therapeutic use, Keratoconjunctivitis Sicca drug therapy, gamma-Linolenic Acid therapeutic use
- Abstract
Purpose: Supplementation with gamma-linolenic acid (GLA) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) has been found to decrease the production of disease-relevant inflammatory mediators that are implicated in the pathogenesis of chronic dry eye. This study evaluated the effect of a supplement containing both GLA and n-3 PUFAs on signs and symptoms of moderate-to-severe keratoconjunctivitis sicca in postmenopausal patients., Methods: This multicenter, double-masked placebo-controlled clinical trial enrolled 38 patients (both eyes) with tear dysfunction who were randomized to supplemental GLA + n-3 PUFAs or placebo for 6 months. Disease parameters, including Ocular Surface Disease Index, Schirmer test, tear breakup time, conjunctival fluorescein and lissamine green staining, and topographic corneal smoothness indexes (surface asymmetry index and surface regularity index), were assessed at baseline and at 4, 12, and 24 weeks. The intensity of dendritic cell CD11c integrin and HLA-DR expression was measured in conjunctival impression cytologies., Results: The Ocular Surface Disease Index score improved with supplementation and was significantly lower than placebo (21 ± 4 vs. 34 ± 5) after 24 weeks (P = 0.05, n = 19 per group). The surface asymmetry index was significantly lower in supplement-treated subjects (0.37 ± 0.03, n = 15) than placebo (0.51 ± 0.03, n = 16) at 24 weeks (P = 0.005). Placebo treatment also significantly increased HLA-DR intensity by 36% ± 9% and CD11c by 34% ± 7% when compared with supplement treatment (n = 19 per group, P = 0.001, 24 weeks). Neither treatment had any effect on tear production, tear breakup time, or corneal or conjunctival staining., Conclusions: Supplemental GLA and n-3 PUFAs for 6 months improved ocular irritation symptoms, maintained corneal surface smoothness, and inhibited conjunctival dendritic cell maturation in patients with postmenopausal keratoconjunctivitis sicca.Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00883649.
- Published
- 2013
- Full Text
- View/download PDF
33. Azelastine hydrochloride, a dual-acting anti-inflammatory ophthalmic solution, for treatment of allergic conjunctivitis.
- Author
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Williams PB, Crandall E, and Sheppard JD
- Abstract
Over 50% of patients who seek treatment for allergies present with ocular symptoms. Our current ability to control ocular allergic symptoms is greater than ever before. Newer dual-acting topical eyedrops attack multiple facets of the allergic cascade. Azelastine has antihistaminic effects providing immediate relief, mast cell stabilization providing early-phase intervention, and inhibition of expression and activation of anti-inflammatory mediators which characterize the late phase of the immune reaction. The ophthalmic eyedrop formulation is approved for treatment of allergic conjunctivitis in adults and children aged over 3 years. In clinical trials comparing azelastine with other dual-acting eyedrops, such as levocabastine and olopatadine, azelastine was reported to be slightly less efficacious and to sting briefly upon administration. Even so, many patients experienced the full benefit of symptom relief, and preferred azelastine. As a broad-spectrum drug, azelastine offers many desirable properties for management of ocular allergies. Because it can often produce maximal effect with just twice-daily dosing, azelastine is a particularly good choice for the allergic population in whom minimizing exposure to topical products and preservatives is a key concern.
- Published
- 2010
- Full Text
- View/download PDF
34. Modalities to decrease stromal herpes simplex keratitis reactivation rates.
- Author
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Sheppard JD, Wertheimer ML, and Scoper SV
- Subjects
- Acyclovir analogs & derivatives, Acyclovir therapeutic use, Administration, Topical, Antiviral Agents therapeutic use, Combined Modality Therapy, Cyclosporine administration & dosage, Drug Therapy, Combination, Electrocoagulation methods, Eyelids surgery, Glucocorticoids therapeutic use, Humans, Immunosuppressive Agents administration & dosage, Keratitis, Herpetic virology, Lacrimal Apparatus surgery, Retrospective Studies, Secondary Prevention, Valacyclovir, Valine analogs & derivatives, Valine therapeutic use, Corneal Stroma virology, Dry Eye Syndromes therapy, Herpesvirus 1, Human physiology, Keratitis, Herpetic prevention & control, Virus Activation
- Abstract
Objective: To evaluate the efficacy of adjunctive treatments to decrease herpes simplex keratitis (HSK) recurrences in patients with simultaneous stromal HSK and dry eye disease., Methods: This was a nonrandomized, single-center, retrospective, comparative analysis. Forty-two patients were diagnosed with unilateral HSK and dry eye disease. Of the 42 patients, 22 were treated with ipsilateral punctal occlusion by thermal cautery and 10 were treated with topical administration of cyclosporine, 0.05%, ophthalmic emulsion twice a day. Another group of 10 patients had previously undergone punctal occlusion and had cyclosporine ophthalmic emulsion twice a day added. All patients continued the use of oral acyclovir or valacyclovir hydrochloride and topical steroids. The frequency and duration of HSK recurrences were monitored for 1 year after initiation of treatment, and the rates were compared with those in the prior year., Results: The thermal cautery and topical cyclosporine groups experienced HSK recurrences for mean durations of 7.1 and 5.8 mo/y before treatment, respectively, and these were reduced to 1.1 mo/y after treatment in both groups. Topical administration of cyclosporine further reduced the duration of HSK recurrences in patients with prior thermal cautery from an average of 1.3 mo/y before the addition of cyclosporine to 0.8 mo/y after the addition of cyclosporine., Conclusion: Permanent punctal occlusion by thermal cautery and the use of topical cyclosporine independently reduced recurrences of stromal HSK.
- Published
- 2009
- Full Text
- View/download PDF
35. Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effects.
- Author
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Hosseini A, Lattanzio FA, Williams PB, Tibbs D, Samudre SS, and Allen RC
- Subjects
- Animals, Antihypertensive Agents adverse effects, Benzoxazines, Blood Pressure drug effects, Cornea drug effects, Cornea pathology, Drug Administration Schedule, Glaucoma physiopathology, Heart Rate drug effects, Male, Microscopy, Confocal, Morpholines adverse effects, Naphthalenes adverse effects, Ophthalmic Solutions, Rats, Rats, Sprague-Dawley, Antihypertensive Agents therapeutic use, Glaucoma drug therapy, Morpholines therapeutic use, Naphthalenes therapeutic use
- Abstract
Glaucoma, one of the leading causes of blindness, is associated with high intraocular pressure (IOP) as a risk factor. The aim of this study was to examine both local and systemic effects of chronic topical administration of the synthetic CB1/CB2 agonist, WIN-55-212-2 and its potential to sustain ocular hypotension. WIN-55-212-2 (0.5%) or Tocrisolve, the vehicle, was administered topically three times daily to rats with surgically created glaucoma for 4 weeks, followed by a 1-week washout period. IOP, blood pressure and heart rate were measured weekly along with confocal microscopy and slit lamp biomicroscopy to detect ocular toxicity. IOP decreased rapidly by up to 47% in the WIN-55-212-2 treated group from 14.1+/-0.7 to 6.6+/-0.2 mmHg. The decrease was maintained during the treatment period. After the washout period, IOP (12.3+/-0.2 mmHg) was not different from baseline. In the contralateral eye, IOP showed a downward trend. Tocrisolve alone had no effect on IOP. No changes in blood pressure, heart rate or indicators of ocular toxicity were noted within either group. Topical application of WIN-55-212-2 significantly deceased IOP for duration of treatment. The decrease was sustained without the development of tolerance. Following cessation of therapy, IOP rapidly returned to baseline. No significant cardiovascular effects or ocular toxicity were noted during chronic topical therapy with either drug or vehicle.
- Published
- 2006
- Full Text
- View/download PDF
36. Argon laser photodynamic therapy of human corneal neovascularization after intravenous administration of dihematoporphyrin ether.
- Author
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Sheppard JD Jr, Epstein RJ, Lattanzio FA Jr, Marcantonio D, and Williams PB
- Subjects
- Adult, Aged, Corneal Neovascularization physiopathology, Dihematoporphyrin Ether adverse effects, Female, Follow-Up Studies, Humans, Injections, Intravenous, Lasers, Male, Middle Aged, Photosensitizing Agents adverse effects, Prospective Studies, Treatment Outcome, Corneal Neovascularization drug therapy, Dihematoporphyrin Ether administration & dosage, Hematoporphyrin Photoradiation, Photosensitizing Agents administration & dosage
- Abstract
Purpose: Long-term evaluation of dihematoporphyrin ether (DHE) safety and efficacy as photodynamic therapy (PDT) for patients with corneal neovascularization (KNV)., Design: Prospective multi-center interventional case series., Methods: Seven patients were enrolled after Institutional Review Board approval and a detailed informed consent were obtained. Eligible patients presented with clinically stable KNV without active vessel progression or inflammation. All patients with severe hypertension, history of renal or hepatic disease, or sensitivity to porphyrins, and those with active keratitis or uncontrolled ocular surface disease were excluded. DHE was administered as an intravenous bolus (2 mg/kg). Seventy-two hours later, PDT was carried out using argon green laser (514 nm). The main outcome measure, extent of vascular thrombosis, was estimated during postoperative follow-up examinations performed at day 1, 1 week, 6 months, and up to 12 years postoperative., Results: All patients obtained an immediate reduction in measurable corneal vascularization. With at least 6 months of follow-up, six of seven patients maintained a significant reduction (52.5% +/- 19.6%, P < .01) in KNV. The mean length of followup was 5.4 years (Range = 6 months to 12 years) during which time there were no other ocular changes attributable to laser treatment. Three patients suffered significant systemic short-term phototoxicity reactions., Conclusions: Intravenous DHE followed by photodynamic treatment in humans is effective for the reduction of inactive, established KNV. However, the significant short-term adverse effects related to systemic administration of this drug are of particular concern and warrant further investigation.
- Published
- 2006
- Full Text
- View/download PDF
37. Cyclosporin as an adjunct to glaucoma filtration surgery.
- Author
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Lattanzio FA Jr, Crouch ER Jr, Mitrev PV, Williams PB, and Allen RC
- Subjects
- Administration, Topical, Animals, Antibiotics, Antineoplastic therapeutic use, Combined Modality Therapy, Conjunctiva physiology, Conjunctiva surgery, Female, Fistula, Glaucoma physiopathology, Intraoperative Care methods, Mitomycin therapeutic use, Ophthalmic Solutions, Rabbits, Cyclosporine therapeutic use, Filtering Surgery, Glaucoma drug therapy, Glaucoma surgery, Immunosuppressive Agents therapeutic use, Intraocular Pressure
- Abstract
Purpose: Current adjunctive therapies to glaucoma surgery have unreliable effects, are toxic, and have numerous late complications associated with their use. This study examined whether topical cyclosporin (CsA) prolongs bleb survival after glaucoma filtration surgery., Methods: Anesthetized white New Zealand rabbits underwent glaucoma filtration surgery with a drainage tube. Cyclosporin (2%), applied intraoperatively or as topical treatment following glaucoma filtration surgery, was compared with intraoperative mitomycin C (MMC) and an untreated control group., Results: The bleb remained elevated for 15.1 +/- 3.2 days in the untreated control group, 12.2 +/- 2.1 days after intraoperative cyclosporin, and 27.5 +/- 1.7 days after intraoperative mitomycin C (P < 0.001). When topical treatment with cyclosporin followed intraoperative mitomycin C, bleb survival significantly decreased to 19.2 +/- 4.6 days (P = 0.003). Intraocular pressure (IOP) remained significantly reduced in the mitomycin C-treated group longer than in either the control or cyclosporine-treated groups., Conclusions: In comparison with mitomycin C, neither intraoperative nor postoperative treatment with cyclosporin was associated with a decrease in intraocular pressure or prolonged bleb survival. Contrary to the initial hypothesis, topical treatment with cyclosporin actually mitigated the beneficial effects of mitomycin C on bleb survival. Clinical implications of these findings for patients with functioning blebs deserve further study.
- Published
- 2005
- Full Text
- View/download PDF
38. Omalizumab: a future innovation for treatment of severe ocular allergy?
- Author
-
Williams PB and Sheppard JD Jr
- Subjects
- Aged, Animals, Antibodies, Anti-Idiotypic, Antibodies, Monoclonal, Humanized, Conjunctivitis, Allergic immunology, Humans, Hypersensitivity, Immediate immunology, Keratoconjunctivitis immunology, Male, Omalizumab, Anti-Allergic Agents therapeutic use, Antibodies, Monoclonal therapeutic use, Conjunctivitis, Allergic drug therapy, Hypersensitivity, Immediate drug therapy, Keratoconjunctivitis drug therapy
- Abstract
Conjunctival and corneal manifestations of atopic keratoconjunctivitis (AKC) are chronic, disabling and may be blinding. In common with other allergic diseases, such as asthma and atopic dermatitis, AKC is characterised by an allergen-induced immune response mediated through expression of IgE. The humanised monoclonal IgE antibody Xolair (omalizumab) complexes with free circulating IgE, thereby preventing binding of IgE to FcepsilonRI receptors on immune cells. Omalizumab effectively alleviates the signs and symptoms of asthma. Given the pivotal role of IgE in the allergic cascade, it is hypothesised that omalizumab has potential as an entirely new therapeutic approach to AKC.
- Published
- 2005
- Full Text
- View/download PDF
39. Do injections of 5-fluorouracil after trabeculectomy have toxic effects on the anterior segment?
- Author
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Lattanzio FA Jr, Sheppard JD Jr, Allen RC, Baynham S, Samuel P, and Samudre S
- Subjects
- Animals, Anterior Eye Segment metabolism, Anterior Eye Segment ultrastructure, Antimetabolites administration & dosage, Antimetabolites pharmacokinetics, Antimetabolites therapeutic use, Aqueous Humor metabolism, Female, Fluorouracil administration & dosage, Fluorouracil pharmacokinetics, Fluorouracil therapeutic use, Injections, Intralesional, Microscopy, Confocal, Microscopy, Electron, Scanning, Proteins analysis, Rabbits, Wound Healing drug effects, Anterior Eye Segment drug effects, Antimetabolites toxicity, Fluorouracil toxicity, Intraocular Pressure drug effects, Trabeculectomy
- Abstract
Objective: To discourage fibrosis of the filtering bleb, 5 fluorouracil (5-FU) may be injected after trabeculectomy. 5-FU is an antimetabolite that also can damage extraocular tissues at concentrations as low as 0.5%. This study ascertained whether repeated injection of 5-FU has toxic effects on intraocular structures., Methods: After unilateral trabeculectomy in anesthetized New Zealand rabbits, 5-FU (5.0 mg/0.1 mL) was injected at the trabeculectomy site every 5 days for 15 days. Evaluation included slit-lamp examination, confocal microscopy, and intraocular pressure (IOP). After sacrifice, aqueous humor (AH) was drawn and eyes excised for scanning electron microscopy (SEM) and light microscopy., Results: The 5-FU injection not decrease IOP beyond trabeculectomy alone. Bleb height remained constant, thickness increased, and vascularity decreased. No changes in cornea or anterior segment were observed. No inflammation was observed in the bleb or surrounding tissues by slit-lamp or histologic examination. Protein in AH increased from 0.6 +/- 0.5 microg/mL at baseline to 19.8 +/- 4.4 microg/mL after trabeculectomy but only to 0.9 +/- 0.6 microg/mL after trabeculectomy plus 5-FU. Both in vivo confocal microscopy and SEM revealed deleterious effects on corneal epithelial and endothelial cells with a minor shift toward smaller cells., Conclusions: In this study 5-FU did not provoke an intraocular inflammatory response and had minimal effect on extraocular structures. Changes in corneal epithelium and endothelium detectable by confocal microscopy suggest a small toxic effect. These in vivo measurements by confocal microscopy were confirmed by SEM. Repeated administration did not cause additional cumulative toxic effects in the anterior segment. Therefore, multiple injections of 5- FU into the filtering bleb pose minimal risk to intraocular structures.
- Published
- 2005
- Full Text
- View/download PDF
40. Confocal microscopy used as the definitive, early diagnostic method in Chandler syndrome.
- Author
-
Sheppard JD Jr, Lattanzio FA Jr, Williams PB, Mitrev PV, and Allen RC
- Subjects
- Glaucoma diagnosis, Gonioscopy, Humans, Male, Middle Aged, Syndrome, Visual Acuity, Visual Fields, Corneal Diseases diagnosis, Endothelium, Corneal pathology, Iris Diseases diagnosis, Microscopy, Confocal methods
- Abstract
Purpose: To report the early, rapid diagnosis of the Chandler variant of the iridocorneal endothelial (ICE) syndrome using confocal light microscopy., Methods: A 62-year-old man with a long history of unilateral glaucoma reported progressively blurred vision in his right eye. Examination of both eyes included visual acuity, slit-lamp examination, pneumotonometry, visual field, gonioscopy, and confocal microscopy., Results: On examination, visual acuity was 20/80 and 20/20 and the IOPs were 26 and 12. The anterior segment OD revealed 1+ inferior and axial corneal edema, while the OS was normal to biomicroscopy and posterior segment. Chandler syndrome or Fuchs endothelial dystrophy was suspected. In the affected eye, confocal light microscopy clearly showed an "epithelium-like" transformation of the corneal endothelium with irregularly shaped cells and hyperreflective nuclei, establishing the diagnosis of Chandler syndrome., Conclusions: In the presence of corneal edema or haze, corneal endothelium can be clearly visualized by confocal microscopy. "Epithelium-like" endothelial cells with highly reflective nuclei characteristic of Chandler syndrome were easily identified by confocal light microscopy to establish the diagnosis, despite the presence of corneal edema. Thus, confocal microscopy is a sensitive tool for the rapid, early diagnosis of ICE syndrome and may help distinguish among its variants.
- Published
- 2005
- Full Text
- View/download PDF
41. Comparison of topical steroids for acute anterior uveitis.
- Author
-
Samudre SS, Lattanzio FA Jr, Williams PB, and Sheppard JD Jr
- Subjects
- Acute Disease, Administration, Topical, Androstadienes administration & dosage, Androstadienes therapeutic use, Animals, Aqueous Humor chemistry, Aqueous Humor drug effects, Blotting, Western, Conjunctiva blood supply, Conjunctiva physiopathology, Corneal Stroma chemistry, Corneal Stroma drug effects, Corneal Stroma pathology, Dexamethasone administration & dosage, Dexamethasone analogs & derivatives, Dexamethasone therapeutic use, Endothelium, Corneal drug effects, Endothelium, Corneal pathology, Endothelium, Corneal physiopathology, Eye Proteins analysis, Fibrin analysis, Fluorometholone administration & dosage, Fluorometholone therapeutic use, Glucocorticoids administration & dosage, Intraocular Pressure drug effects, Lipopolysaccharides administration & dosage, Lipopolysaccharides toxicity, Loteprednol Etabonate, Male, Particle Size, Prednisolone administration & dosage, Prednisolone analogs & derivatives, Prednisolone therapeutic use, Rabbits, Receptors, Glucocorticoid metabolism, Suspensions, Time Factors, Uveitis, Anterior chemically induced, Uveitis, Anterior metabolism, Vitreous Body chemistry, Vitreous Body drug effects, Vitreous Body pathology, Glucocorticoids therapeutic use, Uveitis, Anterior drug therapy
- Abstract
This study objectively compares efficacy of dexamethasone Na phosphate 0.1%, fluorometholone 0.1% (FML), loteprednol etabonate 0.5% (Lotemax [LE]; Bausch & Lomb Pharmaceuticals, Inc., Tampa, FL), prednisolone acetate 1% (Pred Forte [PRED F]; Allergan Pharmaceuticals, Irvine, CA), and generic prednisolone acetate 1% (PRED A). These steroids were administered for 24 hours or 72 hours to New Zealand white rabbits with endotoxin-induced uveitis. Intraocular pressure (IOP), slit-lamp examination, and confocal microscopy were performed daily. Internalization of the glucocorticoid receptor (GC) was assayed in iris tissue by Western blot, and protein in aqueous humor by Bradford assay. Only LE and PRED F treatments significantly internalized GC receptor after 72 hours of treatment. Only LE and PRED A reduced protein concentration between 24 hours and 72 hours of treatment. All drugs improved clinical signs after 24 hours of treatment. None of the steroids promoted return of the inflammation-induced corneal thickness to baseline. While none returned IOP to baseline, LE was most effective. Confocal microscopy indicated that only treatment with LE reverted the abnormal endothelial-cell shape to normal. In conclusion, all steroid treatments reduced uveitis to some degree but LE was consistently effective. A longer observation period may be required to document the return of IOP and corneal thickness to baseline values.
- Published
- 2004
- Full Text
- View/download PDF
42. Cyclosporin-augmented laser peripheral iridoplasty.
- Author
-
Crouch ER Jr, Lattanzio FA Jr, Williams PB, Mitrev PV, Theobald T, and Allen RC
- Subjects
- Animals, Aqueous Humor metabolism, Combined Modality Therapy, Dexamethasone therapeutic use, Eye Proteins metabolism, Glucocorticoids therapeutic use, Intraocular Pressure, Iritis prevention & control, Rabbits, Cyclosporine therapeutic use, Immunosuppressive Agents therapeutic use, Iridectomy, Iris drug effects, Iris surgery, Laser Therapy methods
- Abstract
Background and Objective: Almost all patients develop iritis following argon laser peripheral iridoplasty. Numerous adverse effects, particularly elevated intraocular pressure (IOP) and reduced microbial resistance, complicate therapy with topical corticosteroids. An immunomodulator, such as cyclosporin A (CsA), avoids these undesirable effects, yet may suppress ocular inflammation., Materials and Methods: Argon laser peripheral iridoplasty was performed on anesthetized rabbits with pigmented iris epithelium. Rabbits were randomly assigned to the untreated control, CsA (2%), or dexamethasone (0.1%) groups. Postoperative inflammation was documented by digital photography, IOP, and protein in aqueous humor., Results: Iris injection, aqueous flare, and fibrin decreased most rapidly in the control group, as did protein in aqueous humor. Decreases in IOP of 49% to 58% were similar in all three groups. There were no differences in conjunctival congestion between the, Conclusion: Neither treatment with antiinflammatory drugs that inhibit phagocytosis (e.g., topical steroids) nor treatment with anti-inflammatory drugs that suppress T-lymphocytes (e.g., topical sA) significantly attenuated inflammation following iridoplasty.
- Published
- 2004
43. Evaluation of student achievement and educational outcomes.
- Author
-
Williams PB, Lathers CM, Smith CM, Payer A, and Volle RL
- Subjects
- Problem-Based Learning, Reproducibility of Results, Software, Teaching, Educational Status, Pharmacology, Clinical education
- Abstract
Development of problem-solving skills is vital to professional education as is factual recall. Student mastery must be measured to document student achievement requiredfor completion of educational requirements and professional certification. These measurements also help determine if the educational process is meeting its goal of helping students develop critical cognitive skills for therapeutic problem solving. Testing student growth in the ability to solve problems is less understood. Stressing integration of information across disciplines to derive answers is also important. Test items should resemble the real-world task that students are expected to master. Thatisreallythe essence of content validity, which means faculty should be biased toward presenting information that way. This article is based on a symposium presented at the annual meeting of the American College of Clinical Pharmacology in September 1996. Symposium goals were to define purposes and uses of student evaluations by type and format, including application of techniques that improve evaluation, precision, and validity. Technical applications of computer-based learning and evaluation of problem-solving skills are described. Actual experience with evaluation of problem solving in the curriculum is discussed. The process by which a medical school developed and implemented an evaluation system for a new problem-based curriculum is presented, followed by a critique of the successes and problems encountered during the first year of implementation. Criteria that a well-constructed evaluation program must meet are explored. The approach and philosophy of national standardized testing centers are explained.
- Published
- 2001
- Full Text
- View/download PDF
44. The birth of ocular pharmacology in the 20th century.
- Author
-
Williams PB, Crouch ER Jr, Sheppard JD Jr, Lattanzio FA Jr, Parker TA, and Mitrev PV
- Subjects
- Anti-Allergic Agents therapeutic use, Anti-Infective Agents therapeutic use, Anti-Inflammatory Agents therapeutic use, Blindness etiology, Blindness prevention & control, Eye Diseases complications, Eye Diseases drug therapy, Eye Diseases surgery, Glaucoma etiology, Glaucoma surgery, History, 20th Century, Humans, Mydriatics administration & dosage, Mydriatics therapeutic use, Ophthalmology trends, Palliative Care, Eye Diseases therapy, Ophthalmology history
- Abstract
Nineteenth century ophthalmology, characterized by significant gains in diagnostic techniques, provided the basis for great advancements in treatment during the 20th century. Drug therapy at the turn of the century was empiric, palliative, and often toxic. The development of ocular pharmacology during the 20th century provided the basis for a rational therapeutic approach to ocular disease. Foremost among the therapeutic developments were antibiotics, due to their potential to cure conditions that frequently resulted in blindness. Second, other therapeutic classes provided palliative therapy for chronic diseases, and thus decreased morbidity. For example, drugs specifically targeting many different aspects of glaucoma have had remarkable success controlling intraocular pressure and forestalling development of blindness. In addition, other new approaches provided palliative therapy for nonblinding conditions and effective adjuncts to surgical procedures. Antiallergy and anti-inflammatory drugs greatly increased patient comfort and facilitated treatment of allergic and inflammatory reactions. Local anesthetics and analgesia reduced patient discomfort during surgery. Other adjunct drugs improved surgical outcomes by reducing inflammation and infectious complications. The 21st century will undoubtedly provide novel approaches to address many of today's therapeutic dilemmas. Photodynamic therapy, growth factors, antisense technology, and genetic-based therapies all show great promise. Many of the conditions that are only treated palliatively today will be curable in the next century using many of these pharmacological advances.
- Published
- 2000
- Full Text
- View/download PDF
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