Search

Your search keyword '"Thomassigny, Christine"' showing total 116 results
Start Over Author "Thomassigny, Christine"
116 results on '"Thomassigny, Christine"'

11. Synthesis of Nitrogen- and Oxygen-Containing Heterocycles by Prins Cyclization in Continuous Flow.

Author

Talavera-Alemán, Armando, Marrot, Jérome, Dagousset, Guillaume, and Thomassigny, Christine

Subjects
RING formation (Chemistry), BICYCLIC compounds, CHEMICAL reactions, HETEROCYCLIC compounds, PYRAN derivatives, SILYL ethers
Abstract

Aza-silyl-Prins and oxa-Prins cyclization reactions in continuous-flow chemistry are described for the synthesis of the corresponding tetrahydropyridines and pyran derivatives, respectively. In particular, the use of pyridine-carboxaldehydes for aza-silyl-Prins reaction led to either a symmetrical triarylmethane or two new bicyclic compounds. 4-Fluorinated-2-substituted tetrahydropyran derivatives were also obtained in the oxa-Prins cyclization with good selectivity in favor of the anti -isomer. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

19. Amino acid-catalyzed asymmetric alpha-amination of carbonyls

Author

Thomassigny, Christine, Prim, Damien, Greck, Christine, Institut Lavoisier de Versailles (ILV), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Published
2006

46. Asymmetric syntheses of functionalized pyrrolizidin-3-ones.

Author

Thomassigny, Christine, Le Bouc, Géraldine, and Greck, Christine

Subjects
*ASYMMETRIC synthesis, *PYRROLIZIDINES, *KETONES, *ELECTROPHILES, *AMINATION, *HYDROXYLATION, *STEREOSELECTIVE reactions, *CHEMICAL reduction, *CATALYSIS
Abstract

The syntheses of 1- and 7-hydroxypyrrolizidin-3-ones are described via asymmetric catalytic hydrogenation or diastereoselective reduction of ketones as key steps. 2,7-Disubstituted pyrrolizidin-3-ones are also prepared. The second chiral center is created using stereoselective electrophilic amination or hydroxylation reactions. [ABSTRACT FROM AUTHOR]

Published
2012

47. Diastereoselective syntheses of 1-deoxyhomonojirimycin and two new 1,5,6-trideoxy-1,5-iminoheptitols with d-allo- and l-talo-configuration

Author

Le Bouc, Géraldine, Thomassigny, Christine, and Greck, Christine

Subjects
*LINE geometry, *MATHEMATICAL transformations, *ALGORITHMS, *DIFFERENTIAL invariants
Abstract

Abstract: The synthesis of 1-deoxyhomonojirimycin 2, as well as two new diastereomers, namely 1,5,6-trideoxy-1,5-imino-d-allo-heptitol 3 and 1,5,6-trideoxy-1,5-imino-l-talo-heptitol 4, is described. Compound 2 was obtained from 1,2:5,6-di-O-isopropylidene-α-d-glucofuranose—while 3 and 4 were obtained from 1,2:5,6-di-O-isopropylidene-α-d-allofuranose. These compounds were transformed in a few steps to the corresponding β-ketoesters 12 and 18, respectively, which were hydrogenated diastereoselectively in the presence of chiral ruthenium complexes with total control of the C-5 stereogenic centre. The resulting β-hydroxyesters 13, 19a and 19b are key intermediates for the syntheses of the 1,5,6-trideoxy-1,5-iminoheptitols 2, 3 and 4, respectively. [Copyright &y& Elsevier]

Published
2006
Full Text
View/download PDF

48. Asymmetric Electrophilic α-Amination of Carbonyl Groups

Author

Greck, Christine, Drouillat, Bruno, and Thomassigny, Christine

Abstract

The electrophilic amination constitutes an unconventional C−N bond-forming reaction. Asymmetric versions have been developed using chiral reagents or catalysts and starting from optically pure substrates. The aminated products can be obtained with high stereoselectivities. These methodologies are flexible routes for the synthesis of α-amino acids and nitrogen heterocycles. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

Published
2004
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results