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271 results on '"Thompson, Atalie C"'

2. From Machine to Machine: An OCT-trained Deep Learning Algorithm for Objective Quantification of Glaucomatous Damage in Fundus Photographs

Author

Medeiros, Felipe A., Jammal, Alessandro A., and Thompson, Atalie C.

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence
Abstract

Previous approaches using deep learning algorithms to classify glaucomatous damage on fundus photographs have been limited by the requirement for human labeling of a reference training set. We propose a new approach using spectral-domain optical coherence tomography (SDOCT) data to train a deep learning algorithm to quantify glaucomatous structural damage on optic disc photographs. The dataset included 32,820 pairs of optic disc photos and SDOCT retinal nerve fiber layer (RNFL) scans from 2,312 eyes of 1,198 subjects. A deep learning convolutional neural network was trained to assess optic disc photographs and predict SDOCT average RNFL thickness. The performance of the algorithm was evaluated in an independent test sample. The mean prediction of average RNFL thickness from all 6,292 optic disc photos in the test set was 83.3$\pm$14.5 $\mu$m, whereas the mean average RNFL thickness from all corresponding SDOCT scans was 82.5$\pm$16.8 $\mu$m (P = 0.164). There was a very strong correlation between predicted and observed RNFL thickness values (r = 0.832; P<0.001), with mean absolute error of the predictions of 7.39 $\mu$m. The areas under the receiver operating characteristic curves for discriminating glaucoma from healthy eyes with the deep learning predictions and actual SDOCT measurements were 0.944 (95$\%$ CI: 0.912- 0.966) and 0.940 (95$\%$ CI: 0.902 - 0.966), respectively (P = 0.724). In conclusion, we introduced a novel deep learning approach to assess optic disc photographs and provide quantitative information about the amount of neural damage. This approach could potentially be used to diagnose and stage glaucomatous damage from optic disc photographs.

Published
2018

9. Association of fractal dimension and other retinal vascular network parameters with cognitive performance and neuroimaging biomarkers: The Multi‐Ethnic Study of Atherosclerosis (MESA)

Author

Ong, Sally S., primary, Peavey, Jeremy J., additional, Hiatt, Kevin D., additional, Whitlow, Christopher T., additional, Sappington, Rebecca M., additional, Thompson, Atalie C., additional, Lockhart, Samuel N., additional, Chen, Haiying, additional, Craft, Suzanne, additional, Rapp, Stephen R., additional, Fitzpatrick, Annette L., additional, Heckbert, Susan R., additional, Luchsinger, José A., additional, Klein, Barbara E. K., additional, Meuer, Stacy M, additional, Cotch, Mary Frances, additional, Wong, Tien Y., additional, and Hughes, Timothy M., additional

Published
2023
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15. Association of fractal dimension and other retinal vascular network parameters with cognitive performance and neuroimaging biomarkers: The Multi‐Ethnic Study of Atherosclerosis (MESA).

Author

Ong, Sally S., Peavey, Jeremy J., Hiatt, Kevin D., Whitlow, Christopher T., Sappington, Rebecca M., Thompson, Atalie C., Lockhart, Samuel N., Chen, Haiying, Craft, Suzanne, Rapp, Stephen R., Fitzpatrick, Annette L., Heckbert, Susan R., Luchsinger, José A., Klein, Barbara E. K., Meuer, Stacy M, Cotch, Mary Frances, Wong, Tien Y., and Hughes, Timothy M.

Abstract

INTRODUCTION: Retinal vascular network changes may reflect the integrity of the cerebral microcirculation, and may be associated with cognitive impairment. METHODS: Associations of retinal vascular measures with cognitive function and MRI biomarkers were examined amongst Multi‐Ethnic Study of Atherosclerosis (MESA) participants in North Carolina who had gradable retinal photographs at Exams 2 (2002 to 2004, n = 313) and 5 (2010 to 2012, n = 306), and detailed cognitive testing and MRI at Exam 6 (2016 to 2018). RESULTS: After adjustment for covariates and multiple comparisons, greater arteriolar fractal dimension (FD) at Exam 2 was associated with less isotropic free water of gray matter regions (β = −0.0005, SE = 0.0024, p = 0.01) at Exam 6, while greater arteriolar FD at Exam 5 was associated with greater gray matter cortical volume (in mm3, β = 5458, SE = 20.17, p = 0.04) at Exam 6. CONCLUSION: Greater arteriolar FD, reflecting greater complexity of the branching pattern of the retinal arteries, is associated with MRI biomarkers indicative of less neuroinflammation and neurodegeneration. [ABSTRACT FROM AUTHOR]

Published
2024
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16. A Comparison of Black and Non-Black Patients in the Presentation and Treatment of Keratoconus.

Author

Christensen, Michael, Kartchner, Jeffrey, Giegengack, Matthew, and Thompson, Atalie C

Subjects
KERATOCONUS, BLACK people, CORNEAL cross-linking, CORNEAL transplantation, GENERALIZED estimating equations, RACE, RACIAL inequality
Abstract

Purpose: Patients with advanced keratoconus (KCN) are less likely to benefit from corneal cross-linking and may require a partial or full thickness keratoplasty. This study aimed to determine whether racial disparities exist in the clinical presentation and initial treatment recommendations for patients evaluated for KCN. Methods: A single-center retrospective review was conducted on all patients who presented to the cornea department for initial evaluation of KCN between 2018 and 2020. Patients who had undergone prior corneal procedures or surgeries were excluded. Baseline sociodemographic and clinical information was collected and stratified according to black versus non-black race. Generalized estimating equations were used to examine the association between black race and presenting corrected distance visual acuity (CDVA), presence of corneal scarring, keratometry values, Belin ABCD score, and treatment recommendations. Multivariate models were adjusted for patient demographics. Results: A total of 128 patients (251 eyes) were included in this study. In fully adjusted models, black individuals presented with significantly worse CDVA (p < 0.0001) and worse tomographic KCN staging according to the Belin ABCD criteria (p = 0.002) compared to non-blacks. Blacks were also more than four times as likely to present with a thinnest pachymetry < 400 μm (p < 0.0001) and more than three times as likely to have corneal scarring (p = 0.001). Blacks were more than seven times more likely to have keratoplasty recommended as treatment than conservative management such as corneal cross-linking or contact lenses (p = 0.004). Conclusion: Compared with their non-black counterparts, blacks presented with significantly more advanced KCN, which placed them at risk of requiring more invasive treatment plans. Future studies should investigate reasons for such late presentations and aim to mitigate disparities in the presentation and management of KCN. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Relationship of self-reported and performance-based visual function with performance-based measures of physical function: the Health ABC study.

Author

Thompson, Atalie C, Miller, Michael E, Webb, Christopher C, Williamson, Jeff D, and Kritchevsky, Stephen B

Subjects
*VISION, *PHYSICAL mobility, *CONTRAST sensitivity (Vision), *VISUAL acuity, *WALKING speed
Abstract

Background: To assess the relationship between self-reported and performance-based visual impairment (VI) and lower extremity physical function.Methods: Cross-sectional analysis of 2219 Health ABC participants who completed vision testing and the Short Physical Performance Battery (SPPB). Linear regression models used either self-reported (weighted visual function question (VFQ) score)) or performance-based (visual acuity (VA), log contrast sensitivity (LCS), Frisby stereoacuity (SA)) to predict SPPB or its components-gait speed, chair stands, or standing balance-with and without covariate adjustment.Results: Mean age was 73.5 years (range 69-80); 52.4% were female and 37.4% African American. All VI measures were strongly associated with SPPB in unadjusted and adjusted models (p<0.001). A self-reported VFQ score 1 standard deviation lower than the mean (mean 87.8 out of 100) demonstrated a -0.241(95% CI:-0.325, -0.156) adjusted difference in SPPB. After controlling for covariates, VA of <20/40 (41%) demonstrated a -0.496(-0.660, -0.331) lower SPPB score while SA score>85 arcsec (30%) had a -0.449(-0.627, -0.271) adjusted SPPB score versus those with better visual function. LCS<1.55 (28.6%) was associated with a -0.759(-0.938, -0.579) lower and LCS≤1.30 (8%) with a -1.216(-1.515, -0.918) lower adjusted SPPB score relative to better LCS. In a final multivariable model containing multiple vision measures, LCS remained independently associated with SPPB and all components, while SA remained associated with balance (all p<0.05).Conclusions: Both self-reported and performance-based VI are strongly associated with poor lower extremity physical function. These findings may identify a subgroup of older adults with co-existing visual and physical dysfunction who may benefit from targeted screening and intervention to prevent disability. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Association between contrast sensitivity and physical function in cognitively healthy older adults: the Brain Network and Mobility Function Study

Author

Thompson, Atalie C, primary, Chen, Haiying, additional, Miller, Michael E, additional, Webb, Christopher C, additional, Williamson, Jeffrey D, additional, Marsh, Anthony P, additional, Hugenschmidt, Christina, additional, Baker, Laura D, additional, Laurienti, Paul, additional, and Kritchevsky, Stephen B, additional

Published
2023
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26. Retinal Vascular Changes in Alzheimer's Dementia and Mild Cognitive Impairment: A Pilot Study Using Ultra-Widefield Imaging

Author

Pead, Emma, primary, Thompson, Atalie C., additional, Grewal, Dilraj S., additional, McGrory, Sarah, additional, Robbins, Cason B., additional, Ma, Justin P., additional, Johnson, Kim G., additional, Liu, Andy J., additional, Hamid, Charlene, additional, Trucco, Emanuele, additional, Ritchie, Craig W., additional, Muniz, Graciela, additional, Lengyel, Imre, additional, Dhillon, Baljean, additional, Fekrat, Sharon, additional, and MacGillivray, Tom, additional

Published
2023
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32. Deep learning and optical coherence tomography in glaucoma: Bridging the diagnostic gap on structural imaging

Author

Thompson, Atalie C., Falconi, Aurelio, and Sappington, Rebecca M.

Abstract

Glaucoma is a leading cause of progressive blindness and visual impairment worldwide. Microstructural evidence of glaucomatous damage to the optic nerve head and associated tissues can be visualized using optical coherence tomography (OCT). In recent years, development of novel deep learning (DL) algorithms has led to innovative advances and improvements in automated detection of glaucomatous damage and progression on OCT imaging. DL algorithms have also been trained utilizing OCT data to improve detection of glaucomatous damage on fundus photography, thus improving the potential utility of color photos which can be more easily collected in a wider range of clinical and screening settings. This review highlights ten years of contributions to glaucoma detection through advances in deep learning models trained utilizing OCT structural data and posits future directions for translation of these discoveries into the field of aging and the basic sciences.

Published
2022

44. Optical Coherence Tomography in Patients with Alzheimer’s Disease: What Can It Tell Us?

Author

Song,Ailin, Johnson,Nicholas, Ayala,Alexandria, and Thompson,Atalie C

Subjects
Eye and Brain
Abstract

Ailin Song,1,* Nicholas Johnson,1,* Alexandria Ayala,1 Atalie C Thompson2 1Duke University School of Medicine, Durham, NC, USA; 2Department of Ophthalmology, Duke University, Durham, NC, USA*These authors contributed equally to this workCorrespondence: Atalie C ThompsonDepartment of Ophthalmology, Duke University, 2351 Erwin Road, DUMC 3802, Durham, NC 27710, USATel +1-919-681-3937Fax +1-919-681-8267Email ataliethompson@gmail.comPurpose: Although Alzheimer’s disease (AD) is a leading cause of dementia worldwide, its clinical diagnosis remains a challenge. Optical coherence tomography (OCT) and OCT with angiography (OCTA) are non-invasive ophthalmic imaging tools with the potential to detect retinal structural and microvascular changes in patients with AD, which may serve as biomarkers for the disease. In this systematic review, we evaluate whether certain OCT and OCTA parameters are significantly associated with AD and mild cognitive impairment (MCI).Methods: PubMed database was searched using a combination of MeSH terms to identify studies for review. Studies were organized by participant diagnostic groups, type of imaging modality, and OCT/OCTA parameters of interest. Participant demographic data was also collected and baseline descriptive statistics were calculated for the included studies.Results: Seventy-one studies were included for review, representing a total of 6757 patients (2350 AD, 793 MCI, 2902 healthy controls (HC), and 841 others with a range of other neurodegenerative diagnoses). The mean baseline ages were 72.78± 3.69, 71.52± 2.88, 70.55± 3.85 years for AD, MCI and HC groups, respectively. The majority of studies noted significant structural and functional decline in AD patients when compared to HC. Although analysis of MCI groups yielded more mixed results, a similar pattern of decline was often noted amongst patients with MCI relative to HC. OCT and OCTA measurements were also shown to correlate with established measures of AD such as neuropsychological testing or neuroimaging.Conclusion: OCT and OCTA show great potential as non-invasive technologies for the diagnosis of AD. However, further research is needed to determine whether there are AD-specific patterns of structural or microvascular change in the retina and optic nerve that distinguish AD from other neurodegenerative diseases. Development of sensitive and specific OCT/OCTA parameters will be necessary before they can be used to detect AD in clinical settings.Keywords: optical coherence tomography, optical coherence tomography angiography, Alzheimer’s disease, mild cognitive impairment, dementia

Published
2021

45. Reply to: “Comment on Choroidal Structural Analysis in Alzheimer Disease, Mild Cognitive Impairment, and Cognitively Healthy Controls”

Author

Robbins, Cason B., primary, Greawl, Dilraj S., additional, Thompson, Atalie C., additional, Powers, James H., additional, Soundararajan, Srinath, additional, Koo, Hui Yan, additional, Yoon, Stephen P., additional, Polascik, Bryce W., additional, Liu, Andy J., additional, Agrawal, Rupesh, additional, and Fekrat, Sharon, additional

Published
2021
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