329 results on '"Thompson, Chad M."'
Search Results
2. Inhalation cancer risk assessment for environmental exposure to hexavalent chromium: Comparison of margin-of-exposure and linear extrapolation approaches
3. Exposure to environmentally-relevant concentrations of hexavalent chromium does not induce ovarian toxicity in mice
4. Comparison of threshold of toxicological concern (TTC) values to oral reference dose (RfD) values
5. Assessment of the genotoxicity of tert‐butyl alcohol in an in vivo thyroid comet assay
6. Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment
7. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes.
8. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes.
9. Hexavalent Chromium in Drinking Water
10. Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans
11. An Adverse Outcome Pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events
12. Letter to the editor of environmental pollution: In regard to Wan et al. (2024) “GenX caused liver injury and potential hepatocellular carcinoma of mice via drinking water even at environmental concentration”
13. Assessment of the in vivo genotoxic potential of three smoke flavoring primary product mixtures
14. Ten factors for considering the mode of action of Cr(VI)-induced gastrointestinal tumors in rodents
15. Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations
16. Inhalation cancer risk assessment of cobalt metal
17. A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per‐ and polyfluoroalkyl substances and relevance to human health
18. Letter to “Chepelev et al. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data”
19. Assessment of Mouse Liver Histopathology Following Exposure to HFPO-DA With Emphasis on Understanding Mechanisms of Hepatocellular Death
20. Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans
21. Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures
22. High concentrations of hexavalent chromium in drinking water alter iron homeostasis in F344 rats and B6C3F1 mice
23. Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment
24. Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water
25. Assessment of the mutagenic potential of hexavalent chromium in the duodenum of big blue® rats
26. Assessment of genotoxic potential of Cr(VI) in the mouse duodenum: An in silico comparison with mutagenic and nonmutagenic carcinogens across tissues
27. Hexavalent chromium reduction kinetics in rodent stomach contents
28. Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia
29. Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water
30. Evaluation of Transcriptomic Responses in Livers of Mice Exposed to the Short-Chain PFAS Compound HFPO-DA
31. A robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats
32. Assessment of the mutagenic potential of Cr(VI) in the oral mucosa of Big Blue® transgenic F344 rats
33. Crypt and Villus Transcriptomic Responses in Mouse Small Intestine Following Oral Exposure to Hexavalent Chromium
34. A review of mammalian in vivo genotoxicity of hexavalent chromium: implications for oral carcinogenicity risk assessment
35. Renal clearance parameters for PBPK model analysis of early lifestage differences in the disposition of environmental toxicants
36. Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde
37. Synchrotron-Based Imaging of Chromium and γ-H2AX Immunostaining in the Duodenum Following Repeated Exposure to Cr(VI) in Drinking Water
38. Development of updated RfD and RfC values for medium carbon range aromatic and aliphatic total petroleum hydrocarbon fractions
39. A Genomics-Based Analysis of Relative Potencies of Dioxin-Like Compounds in Primary Rat Hepatocytes
40. An approach for integrating toxicogenomic data in risk assessment: The dibutyl phthalate case study
41. Duodenal GSH/GSSG Ratios in Mice Following Oral Exposure to Cr(VI)
42. Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action
43. Assessment of Mechanistic Data for Hexavalent Chromium-Induced Rodent Intestinal Cancer Using the Key Characteristics of Carcinogens
44. Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium
45. A response to “A quantitative assessment of the carcinogenicity of hexavalent chromium by the oral route and its relevance to human exposure”
46. Considerations for the Implausibility of Leukemia Induction by Formaldehyde
47. Application of the U.S. EPA Mode of Action Framework for Purposes of Guiding Future Research: A Case Study Involving the Oral Carcinogenicity of Hexavalent Chromium
48. Using mechanistic information to support evidence integration and synthesis: a case study with inhaled formaldehyde and leukemia
49. An updated mode of action and human relevance framework evaluation for Formaldehyde-Related nasal tumors
50. An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet
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