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The premise of research in human physiology is to explore a multifaceted system whilst identifying one or a few outcomes of interest. Therefore, the control of potentially confounding variables requires careful thought regarding the extent of control and complexity of standardisation. One common factor to control prior to testing is diet, as food and fluid provision may deviate from participants' habitual diets, yet a self-report and replication method can be flawed by under-reporting. Researchers may also need to consider standardisation of physical activity, whether it be through familiarisation trials, wash-out periods, or guidance on levels of physical activity to be achieved before trials. In terms of pharmacological agents, the ethical implications of standardisation require researchers to carefully consider how medications, caffeine consumption and oral contraceptive prescriptions may affect the study. For research in females, it should be considered whether standardisation between- or within-participants in regards to menstrual cycle phase is most relevant. The timing of measurements relative to various other daily events is relevant to all physiological research and so it can be important to standardise when measurements are made. This review summarises the areas of standardisation which we hope will be considered useful to anyone involved in human physiology research, including when and how one can apply standardisation to various contexts. [ABSTRACT FROM AUTHOR]

Background: Physical activity is important for children's physical, mental and cognitive wellbeing, but many children are insufficiently active. Schools offer a promising setting in which to enable positive health behaviours and teachers can play an influential role in facilitating pupils' physical activity. The aim of this study was to use pupils' physical activity data from wearables to inform teacher-led strategies to improve pupils' physical activity outcomes. Methods: Participants included 11 teachers/classes, and 228 pupils aged 8–11 years from eight primary-schools in England. Baseline pupil physical activity was measured for 2 weeks using a commercially available accelerometer, before data visualisations were used to inform teacher-led strategies with the aim of improving pupils' physical activity. These strategies were then implemented, with physical activity being measured post-data-sharing discussions. Mixed-methods analysis explored the feasibility of using data visualisations to inform teachers' understanding of their pupils' physical activity and the development and implementation of teacher-led, school-specific strategies to increase pupils' physical activity. Results: Teachers understood and reflected on the data visualisations and used their knowledge of the school context to develop and implement bespoke school-specific strategies across the school day which successfully increased physical activity. Strategies included altering the physical or social environment, providing more opportunities and addressing physical activity inequalities. Teachers were encouraged when data showed increases in pupils' physical activity and many expressed the desire to continue addressing physical activity, with a particular focus on the least active pupils. Conclusion: These findings suggest that data-driven insights could be used effectively to inform school-based, teacher-led strategies to increase physical activity. [ABSTRACT FROM AUTHOR]

BACKGROUND: Wearable technologies offer new opportunities to address in‐school physical inactivity. However, children are often excluded from discussing issues which directly impact them, including the use of wearable technologies in a school setting. Thus, the aim of this study is to understand primary school pupils' experiences and perceptions of using wearable physical activity monitoring technologies within schools. METHODS: Nine semi‐structured focus groups were conducted with 41 Year 5 and 6 pupils (19 girls, 22 boys) from 5 primary schools in the South West of England. Focus group transcripts were analyzed using a reflective thematic approach. RESULTS: Pupils made valuable contributions to discussions around wearable technologies, considering both advantages and disadvantages. Most importantly, when discussing use in schools, pupils were mindful that while they wanted to see their own activity and saw benefit in teachers knowing their activity, they felt comparisons in classes could lead to negative emotions for some pupils. CONCLUSION: The findings from this study can contribute to a more detailed understanding of pupils' perspectives, which can help inform school‐based interventions which aim to address physical inactivity and associated inequalities. Instead of using wearable devices for individual pupil ownership, schools should access data‐insights with the intention of changing school practices. [ABSTRACT FROM AUTHOR]

Joss Lake, Future Feeling (Soft Skull Press, 2021), pp. 304. Full of post-transition insecurity and anger, Penfield Henderson--the trans protagonist of Joss Lake's debut novel Future Feeling ---sets his plot [...]

AbstractReducing carbon dioxide emissions in the aviation industry is a formidable challenge. Understanding airline travellers’ willingness to pay for emission reductions could lead to impactful changes in flight pricing and government policies. In this study, we employ a discrete choice experiment to more accurately gauge this willingness to pay. The experiment features a comprehensive analysis of both leisure and business traveller categories, utilising a realistic interface mirroring Google Flights for journeys between Los Angeles and New York. The findings demonstrate that, on average, business flyers exhibit a significantly higher willingness to pay for emission reductions compared to leisure flyers. Notably, a subset of emissions conscious leisure flyers also exhibits a markedly higher willingness to pay. Latent class modelling indicates that this emissions conscious group accounts for about 42% of the leisure flyer sample. The larger group of price focused leisure flyers does not display any significant willingness to pay for emission reduction. Another key finding is that ethical consumption behaviour, not just stronger perceptions related to climate change, is linked to emissions-reducing preferences among both types of flyers. These results provide valuable insights for policy and pricing strategies, emphasising the heterogeneity across and within the business and leisure flyer segments. [ABSTRACT FROM AUTHOR]

The effect of acute exercise on circulating concentrations of vitamin D metabolites is unclear. To address this knowledge gap, we examined the effect of a bout of treadmill‐based exercise versus rest on circulating concentrations of 25(OH)D3, 25(OH)D2, 3‐epi‐25(OH)D3, 24,25(OH)2D3, 1,25(OH)2D3, and vitamin D2 and D3 in healthy men and women. Thirty‐three healthy adults (14 females, 41 (15) years, body mass index 26.2 (3.7) kg/m2, V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_{\mathrm{2}}}{\mathrm{max}}}}$ 36.2 (9.2) ml/kg/min; mean (SD)) completed two laboratory visits involving 60 min of moderate‐intensity treadmill exercise (60% V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_{\mathrm{2}}}{\mathrm{max}}}}$) versus 60 min of seated rest, both in an overnight fasted‐state, as part of a randomised crossover design. Venous blood samples were drawn at baseline, immediately (0 h), 1 h and 24 h after the exercise or rest‐period. There was a significant time × trial interaction effect for total circulating 25(OH)D (P = 0.0148), 25(OH)D3 (P = 0.0127) and 1,25(OH)2D3 (P = 0.0226). Immediately post‐exercise, 25(OH)D, 25(OH)D3 and 1,25(OH)2D3 concentrations were significantly elevated compared to the control resting condition, and 1,25(OH) 2D3 remained significantly elevated 1 h later. Circulating albumin, vitamin D binding protein, calcium and parathyroid hormone were elevated immediately post‐exercise. Thus, an acute bout of moderate intensity exercise transiently increases concentrations of circulating 25(OH)D and 1,25(OH)2D3 compared to resting conditions. Key points: Observational studies suggest that acute exercise might change circulating concentrations of vitamin D metabolites, but this has not been investigated using randomised crossover studies and using robust analytical procedures.In this study, we used a randomised crossover design to examine the effect of a bout of treadmill‐based exercise (vs. rest) on circulating concentrations of a wide range of vitamin D metabolites in healthy humans.We show that an acute bout of moderate intensity exercise transiently increases concentrations of circulating 25(OH)D and 1,25(OH)2D3 compared to resting conditions.These findings indicate that regular exercise could lead to transient but regular windows of enhanced vitamin D biological action. [ABSTRACT FROM AUTHOR]

Background: Generating interest in health interventions is an important first step towards engagement with health promotion and effecting behaviour change. This study explored whether framing health information about physical activity and diet from an evolutionary mismatch perspective could help to generate interest in health promotion among overweight and inactive adults. Evolutionary mismatch theory proposes that human cultural evolution has occurred too rapidly for biological evolution to keep up, creating a mismatch between genes and lifestyles that gives rise to chronic diseases such as type 2 diabetes. Method: A total of 18 adults completed interviews in which they viewed and discussed a variety of mismatch-framed health information resources. Follow-up questions assessed if and what participants had thought about the information in the week after the interview. Transcripts were thematically analysed. Results: Participants found the evolutionary perspective to be novel and interesting. It also provided a meaningful rationale for behaviour change. However, there was some evidence of negative elaboration, which would need to be managed if implementing this approach. Conclusion: Adopting a mismatch perspective can help to engage audiences with important health information.

The aim of this work is to determine the effect of upper‐body high intensity interval training (HIIT) on cardiometabolic risks in individuals with chronic paraplegia. Twenty‐seven individuals (14 females, 13 males, mean ± SD age: 46 ± 9 years) with chronic paraplegia (spinal cord injury between T2 and L5 >1‐year post‐injury) took part in a randomized controlled trial and were included in the final analysis. Participants in the HIIT group (n = 18) performed ∼30 min of arm crank exercise (60 s intervals at 80%–90% peak heart rate) four times per week, for 6 weeks. Participants in the control (CON) group (n = 9) were asked to maintain their habitual diet and physical activity patterns over the study period. Outcome measures were taken at baseline and follow‐up. The primary outcome measures were fasting insulin, peak power output (PPO) and peak aerobic capacity (V̇O2peak${{\dot{V}}_{{{{\mathrm{O}}}_{\mathrm{2}}}{\mathrm{peak}}}}$). Secondary outcome measures included body composition, postprandial glycaemic control, fasting blood lipids, inflammatory biomarkers and resting blood pressure. Differences between groups were assessed by ANCOVA, using baseline values as a covariate. PPO was higher in the HIIT (101 W, 97–106) compared to the CON (90 W, 83–96) group at follow‐up (P = 0.006). There were no differences in fasting insulin (P = 0.415) or relative V̇O2peak${{\dot{V}}_{{{{\mathrm{O}}}_{\mathrm{2}}}{\mathrm{peak}}}}$ (P = 0.417). Postprandial Matsuda insulin sensitivity index (ISIMatsuda) was higher in the HIIT (5.42, 4.69–6.15) compared to the CON (3.75, 2.46–5.04) group at follow‐up (P = 0.036). Six weeks of upper‐body HIIT increased PPO and ISIMatsuda, with no other beneficial effect on cardiometabolic component risks in persons with chronic paraplegia. Highlights: What is the central question of this study?What is the effect of upper‐body high intensity interval training (HIIT) on cardiometabolic component risks in individuals with chronic paraplegia?What is the main finding and its importance?Six weeks of upper‐body HIIT increased PPO and improved insulin sensitivity, but had no beneficial effect on other cardiometabolic component risks in persons with chronic paraplegia. The large effect size observed for insulin sensitivity may be important in terms of reducing the risk of type‐2 diabetes in this population. [ABSTRACT FROM AUTHOR]

The purpose of this study was to examine the feasibility and acceptability of remotely delivered, home-based exercise programs on physical function and well-being in self-isolating older adults during the COVID-19 pandemic. In a four-arm randomized controlled trial, 63 participants (aged 65 years and older) were allocated to one of three home-based daily (2 × 10-min) exercise interventions (exercise snacking, tai chi snacking, and combination) or control (UK National Health Service Web pages). Functional assessments were conducted via video call at baseline and 4-week follow-up. A web-based survey assessed the acceptability of each exercise program and secondary psychological/well-being outcomes. Ecological momentary assessment data, collected in Weeks 1 and 4, explored feeling states as antecedents and consequences of exercise. All intervention groups saw increased physical function at follow-up and displayed good adherence with exercise snacking considered the most acceptable program. Multilevel models revealed reciprocal associations between feelings of energy and exercise engagement. Further studies are needed with larger, more diverse demographic samples. [ABSTRACT FROM AUTHOR]