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774 results on '"Thompson, R. L."'

13. Cost‐effectiveness of emergency versus delayed laparoscopic cholecystectomy for acute gallbladder pathology

Author

Sutton, A. J., Vohra, R. S., Hollyman, M., Marriott, P. J., Buja, A., Alderson, D., Pasquali, S., Griffiths, E. A., Vohra, R. S., Spreadborough, P., Hollyman, M., Marriott, P. J., Kirkham, A., Pasquali, S., Alderson, D., Griffiths, E. A., Fenwick, S., Elmasry, M., Nunes, Q. M., Kennedy, D., Khan, R. B., Khan, M. A. S., Magee, C. J., Jones, S. M., Mason, D., Parappally, C. P., Mathur, P., Saunders, M., Jamel, S., Ul Haque, S., Zafar, S., Shiwani, M. H., Samuel, N., Dar, F., Jackson, A., Lovett, B., Dindyal, S., Winter, H., Fletcher, T., Rahman, S., Wheatley, K., Nieto, T., Ayaani, S., Youssef, H., Nijjar, R. S., Watkin, H., Naumann, D., Emesih, S., Sarmah, P. B., Lee, K., Joji, N., Heath, J., Teasdale, R. L., Weerasinghe, C., Needham, P. J., Welbourn, H., Forster, L., Finch, D., Blazeby, J. M., Robb, W., McNair, A. G. K., Hrycaiczuk, A., Charalabopoulos, A., Kadirkamanathan, S., Tang, C.‐B., Jayanthi, N. V. G., Noor, N., Dobbins, B., Cockbain, A. J., Nilsen‐Nunn, A., de Siqueira, J., Pellen, M., Cowley, J. B., Ho, W.‐M., Miu, V., White, T. J., Hodgkins, K. A., Kinghorn, A., Tutton, M. G., Al‐Abed, Y. A., Menzies, D., Ahmad, A., Reed, J., Khan, S., Monk, D., Vitone, L. J., Murtaza, G., Joel, A., Brennan, S., Shier, D., Zhang, C., Yoganathan, T., Robinson, S. J., McCallum, I. J. D., Jones, M. J., Elsayed, M., Tuck, E., Wayman, J., Carney, K., Aroori, S., Hosie, K. B., Kimble, A., Bunting, D.M., Fawole, A. S., Basheer, M., Dave, R. V., Sarveswaran, J., Jones, E., Kendal, C., Tilston, M. P., Gough, M., Wallace, T., Singh, S., Downing, J., Mockford, K. A., Issa, E., Shah, N., Chauhan, N., Wilson, T. R., Forouzanfar, A., Wild, J. R. L., Nofal, E., Bunnell, C., Madbak, K., Rao, S. T. V., Devoto, L., Siddiqi, N., Khawaja, Z., Hewes, J. C., Gould, L., Chambers, A., Rodriguez, D. U., Sen, G., Robinson, S., Carney, K., Bartlett, F., Rae, D. M., Stevenson, T. E. J., Sarvananthan, K., Dwerryhouse, S. J., Higgs, S. M., Old, O. J., Hardy, T. J., Shah, R., Hornby, S. T., Keogh, K., Frank, L., Al‐Akash, M., Upchurch, E. A., Frame, R. J., Hughes, M., Jelley, C., Weaver, S., Roy, S., Sillo, T. O., Galanopoulos, G., Cuming, T., Cunha, P., Tayeh, S., Kaptanis, S., Heshaishi, M., Eisawi, A., Abayomi, M., Ngu, W. S., Fleming, K., Bajwa, D. S., Chitre, V., Aryal, K., Ferris, P., Silva, M., Lammy, S., Mohamed, S., Khawaja, A., Hussain, A., Ghazanfar, M. A., Bellini, M. I., Ebdewi, H., Elshaer, M., Gravante, G., Drake, B., Ogedegbe, A., Mukherjee, D., Arhi, C., Iqbal, L. G. N., Watson, N. F., Aggarwal, S. K., Orchard, P., Villatoro, E., Willson, P. D., Mok, J., Woodman, T., Deguara, J., Garcea, G., Babu, B. I., Dennison, A. R., Malde, D., Lloyd, D., Satheesan, S., Al‐Taan, O., Boddy, A., Slavin, J. P., Jones, R. P., Ballance, L., Gerakopoulos, S., Jambulingam, P., Mansour, S., Sakai, N., Acharya, V., Sadat, M. M., Karim, L., Larkin, D., Amin, K., Khan, A., Law, J., Jamdar, S., Smith, S. R., Sampat, K., Oʼshea, K. M., Manu, M., Asprou, F. M., Malik, N. S., Chang, J., Johnstone, M., Lewis, M., Roberts, G. P., Karavadra, B., Photi, E., Hewes, J., Gould, L., Chambers, A., Rodriguez, D., OʼReilly, D. A., Rate, A. J., Sekhar, H., Henderson, L. T., Starmer, B. Z., Coe, P. O., Tolofari, S., Barrie, J., Bashir, G., Sloane, J., Madanipour, S., Halkias, C., Trevatt, A. E. J., Borowski, D. W., Hornsby, J., Courtney, M. J., Virupaksha, S., Seymour, K., Robinson, S., Hawkins, H., Bawa, S., Gallagher, P. V., Reid, A., Wood, P., Finch, J. G., Parmar, J., Stirland, E., Gardner‐Thorpe, J., Al‐Muhktar, A., Peterson, M., Majeed, A., Bajwa, F. M., Martin, J., Choy, A., Tsang, A., Pore, N., Andrew, D. R., Al‐Khyatt, W., Taylor, C., Bhandari, S., Chambers, A., Subramanium, D., Toh, S. K. C., Carter, N. C., Tate, S., Pearce, B., Wainwright, D., Mercer, S. J., Knight, B., Vijay, V., Alagaratnam, S., Sinha, S., Khan, S., El‐Hasani, S. S., Hussain, A. A., Bhattacharya, V., Kansal, N., Fasih, T., Jackson, C., Siddiqui, M. N., Chishti, I. A., Fordham, I. J., Siddiqui, Z., Bausbacher, H., Geogloma, I., Gurung, K., Tsavellas, G., Basynat, P., Shrestha, A. K., Basu, S., Mohan, A. C., Harilingam, M., Rabie, M., Akhtar, M., Kumar, P., Jafferbhoy, S. F., Hussain, N., Raza, S., Haque, M., Alam, I., Aseem, R., Patel, S., Asad, M., Booth, M. I., Ball, W. R., Wood, C. P. J., Pinho‐Gomes, A. C., Kausar, A., Obeidallah, M. R., Varghase, J., Lodhia, J., Bradley, D., Rengifo, C., Lindsay, D., Gopalswamy, S., Finlay, I., Wardle, S., Bullen, N., Iftikhar, S. Y., Awan, A., Ahmed, J., Leeder, P., Fusai, G., Bond‐Smith, G., Psica, A., Puri, Y., Hou, D., Noble, F., Szentpali, K., Broadhurst, J., Date, R., Hossack, M. R., Goh, Y. L., Turner, P., Shetty, V., Riera, M., Macano, C. A.W., Sukha, A., Preston, S. R., Hoban, J. R., Puntis, D. J., Williams, S. V., Krysztopik, R., Kynaston, J., Batt, J., Doe, M., Goscimski, A., Jones, G. H., Smith, S. R., Hall, C., Carty, N., Ahmed, J., Panteleimonitis, S., Gunasekera, R. T., Sheel, A. R. G., Lennon, H., Hindley, C., Reddy, M., Kenny, R., Elkheir, N., McGlone, E. R., Rajaganeshan, R., Hancorn, K., Hargreaves, A., Prasad, R., Longbotham, D. A., Vijayanand, D., Wijetunga, I., Ziprin, P., Nicolay, C. R., Yeldham, G., Read, E., Gossage, J. A., Rolph, R. C., Ebied, H., Phull, M., Khan, M. A., Popplewell, M., Kyriakidis, D., Hussain, A., Henley, N., Packer, J. R., Derbyshire, L., Porter, J., Appleton, S., Farouk, M., Basra, M., Jennings, N. A., Ali, S., Kanakala, V., Ali, H., Lane, R., Dickson‐Lowe, R., Zarsadias, P., Mirza, D., Puig, S., Al Amari, K., Vijayan, D., Sutcliffe, R., Marudanayagam, R., Hamady, Z., Prasad, A. R., Patel, A., Durkin, D., Kaur, P., Bowen, L., Byrne, J. P., Pearson, K. L., Delisle, T. G., Davies, J., Tomlinson, M. A., Johnpulle, M. A., Slawinski, C., Macdonald, A., Nicholson, J., Newton, K., Mbuvi, J., Farooq, A., Mothe, B. S., Zafrani, Z., Brett, D., Francombe, J., Spreadborough, P., Barnes, J., Cheung, M., Al‐Bahrani, A. Z., Preziosi, G., Urbonas, T., Alberts, J., Mallik, M., Patel, K., Segaran, A., Doulias, T., Sufi, P. A., Yao, C., Pollock, S., Manzelli, A., Wajed, S., Kourkulos, M., Pezzuto, R., Wadley, M., Hamilton, E., Jaunoo, S., Padwick, R., Sayegh, M., Newton, R. C., Hebbar, M., Farag, S. F., Spearman, J., Hamdan, M. F., DʼCosta, C., Blane, C., Giles, M., Peter, M. B., Hirst, N. A., Hossain, T., Pannu, A., El‐Dhuwaib, Y., Morrison, T. E. M., Taylor, G. W., Thompson, R. L. E., McCune, K., Loughlin, P., Lawther, R., Byrnes, C. K., Simpson, D. J., Mawhinney, A., Warren, C., McKay, D., McIlmunn, C., Martin, S., MacArtney, M., Diamond, T., Davey, P., Jones, C., Clements, J.M., Digney, R., Chan, W. M., McCain, S., Gull, S., Janeczko, A., Dorrian, E., Harris, A., Dawson, S., Johnston, D., McAree, B., Ghareeb, E., Thomas, G., Connelly, M., McKenzie, S., Cieplucha, K., Spence, G., Campbell, W., Hooks, G., Bradley, N., Hill, A. D. K., Cassidy, J. T., Boland, M., Burke, P., Nally, D. M., Hill, A. D. K., Khogali, E., Shabo, W., Iskandar, E., McEntee, G. P., OʼNeill, M. A., Peirce, C., Lyons, E. M., OʼSullivan, A. W., Thakkar, R., Carroll, P., Ivanovski, I., Balfe, P., Lee, M., Winter, D. C., Kelly, M. E., Hoti, E., Maguire, D., Karunakaran, P., Geoghegan, J. G., McDermott, F., Martin, S. T., Cross, K. S., Cooke, F., Zeeshan, S., Murphy, J. O., Mealy, K., Mohan, H. M., Nedujchelyn, Y., Ullah, M. F., Ahmed, I., Giovinazzo, F., Milburn, J., Prince, S., Brooke, E., Buchan, J., Khalil, A. M., Vaughan, E. M., Ramage, M. I., Aldridge, R. C., Gibson, S., Nicholson, G. A., Vass, D. G., Grant, A. J., Holroyd, D. J., Jones, M. A., Sutton, C. M. L. R., OʼDwyer, P., Nilsson, F., Weber, B., Williamson, T. K., Lalla, K., Bryant, A., Carter, C. R., Forrest, C. R., Hunter, D. I., Nassar, A. H., Orizu, M. N., Knight, K., Qandeel, H., Suttie, S., Belding, R., McClarey, A., Boyd, A. T., Guthrie, G. J. K., Lim, P. J., Luhmann, A., Watson, A. J. M., Richards, C. H., Nicol, L., Madurska, M., Harrison, E., Boyce, K. M., Roebuck, A., Ferguson, G., Pati, P., Wilson, M. S. J., Dalgaty, F., Fothergill, L., Driscoll, P. J., Mozolowski, K. L., Banwell, V., Bennett, S. P., Rogers, P. N., Skelly, B. L., Rutherford, C. L., Mirza, A. K., Lazim, T., Lim, H. C. C., Duke, D., Ahmed, T., Beasley, W. D., Wilkinson, M. D., Maharaj, G., Malcolm, C., Brown, T. H., Shingler, G. M., Mowbray, N., Radwan, R., Morcous, P., Wood, S., Kadhim, A., Stewart, D. J., Baker, A. L., Tanner, N., Shenoy, H., Hafiz, S., De Marchi, J. A., Singh‐Ranger, D., Hisham, E., Ainley, P., OʼNeill, S., Terrace, J., Napetti, S., Hopwood, B., Rhys, T., Downing, J., Kanavati, O., Coats, M., Aleksandrov, D., Kallaway, C., Yahya, S., Weber, B., Templeton, A., Trotter, M., Lo, C., Dhillon, A., Heywood, N., Aawsaj, Y., Hamdan, A., Reece‐Bolton, O., McGuigan, A., Shahin, Y., Ali, A., Luther, A., Nicholson, J. A., Rajendran, I., Boal, M., and Ritchie, J.

Published
2017
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14. Predicting the difficult laparoscopic cholecystectomy: development and validation of a pre-operative risk score using an objective operative difficulty grading system

Author

Nassar, A. H. M., Hodson, J., H. J., Ng, Vohra, R. S., Katbeh, T., Zino, S., Griffiths, E. A., Kirkham, A. J., Pasquali, S., Marriott, P., Johnstone, M., Spreadborough, P., Alderson, D., Fenwick, S., Elmasry, M., Nunes, Q. M., Kennedy, D., Khan, R. B., Khan, M. A. S., Magee, C. J., Jones, S. M., Mason, D., Parappally, C. P., Mathur, P., Saunders, M., Jamel, S., Haque, S. U., Zafar, S., Shiwani, M. H., Samuel, N., Dar, F., Jackson, A., Lovett, B., Dindyal, S., Winter, H., Fletcher, T., Rahman, S., Wheatley, K., Nieto, T., Ayaani, S., Youssef, H., Nijjar, R. S., Watkin, H., Naumann, D., Emesih, S., Sarmah, P. B., Lee, K., Joji, N., Lambert, J., Heath, J., Teasdale, R. L., Weerasinghe, C., Needham, P. J., Welbourn, H., Forster, L., Finch, D., Blazeby, J. M., Robb, W., Mcnair, A. G. K., Hrycaiczuk, A., Charalabopoulos, A., Kadirkamanathan, S., Tang, C. -B., Jayanthi, N. V. G., Noor, N., Dobbins, B., Cockbain, A. J., Nilsen-Nunn, A., de Siqueira, J., Pellen, M., Cowley, J. B., W. -M., Ho, Miu, V., White, T. J., Hodgkins, K. A., Kinghorn, A., Tutton, M. G., Al-Abed, Y. A., Menzies, D., Ahmad, A., Reed, J., Khan, S., Monk, D., Vitone, L. J., Murtaza, G., Joel, A., Brennan, S., Shier, D., Zhang, C., Yoganathan, T., Robinson, S. J., Mccallum, I. J. D., Jones, M. J., Elsayed, M., Tuck, L., Wayman, J., Carney, K., Aroori, S., Hosie, K. B., Kimble, A., Bunting, D. M., Fawole, A. S., Basheer, M., Dave, R. V., Sarveswaran, J., Jones, E., Kendal, C., Tilston, M. P., Gough, M., Wallace, T., Singh, S., Mockford, J. D. K. A., Issa, E., Shah, N., Chauhan, N., Wilson, T. R., Forouzanfar, A., Wild, J. R. L., Nofal, E., Bunnell, C., Madbak, K., Rao, S. T. V., Devoto, L., Siddiqi, N., Khawaja, Z., Hewes, J. C., Gould, L., Chambers, A., Rodriguez, D. U., Sen, G., Robinson, S., Bartlett, F., Rae, D. M., Stevenson, T. E. J., Sarvananthan, K., Dwerryhouse, S. J., Higgs, S. M., Old, O. J., Hardy, T. J., Shah, R., Hornby, S. T., Keogh, K., Frank, L., Al-Akash, M., Upchurch, E. A., Frame, R. J., Hughes, M., Jelley, C., Weaver, S., Roy, S., Sillo, T. O., Galanopoulos, G., Cuming, T., Cunha, P., Tayeh, S., Kaptanis, S., Heshaishi, M., Eisawi, A., Abayomi, M., Ngu, W. S., Fleming, K., Bajwa, D. S., Chitre, V., Aryal, K., Ferris, P., Silva, M., Lammy, S., Mohamed, S., Khawaja, A., Hussain, A., Ghazanfar, M. A., Bellini, M. I., Ebdewi, H., Elshaer, M., Gravante, G., Drake, B., Ogedegbe, A., Mukherjee, D., Arhi, C., Giwa, L., Iqbal, N., Watson, N. F., Aggarwal, S. K., Orchard, P., Villatoro, E., Willson, P. D., Mok, K. W. J., Woodman, T., Deguara, J., Garcea, G., Babu, B. I., Dennison, A. R., Malde, D., Lloyd, D., Satheesan, S., Al-Taan, O., Boddy, A., Slavin, J. P., Jones, R. P., Ballance, L., Gerakopoulos, S., Jambulingam, P., Mansour, S., Sakai, N., Acharya, V., Sadat, M. M., Karim, L., Larkin, D., Amin, K., Khan, A., Law, J., Jamdar, S., Smith, S. R., Sampat, K., O'Shea, K. M., Manu, M., Asprou, F. M., Malik, N. S., Chang, J., Lewis, M., Roberts, G. P., Karavadra, B., Photi, E., Hewes, J., Rodriguez, D., O'Reilly, D. A., Rate, A. J., Sekhar, H., Henderson, L. T., Starmer, B. Z., Coe, P. O., Tolofari, S., Barrie, J., Bashir, G., Sloane, J., Madanipour, S., Halkias, C., Trevatt, A. E. J., Borowski, D. W., Hornsby, J., Courtney, M. J., Virupaksha, S., Seymour, K., Hawkins, H., Bawa, S., Gallagher, P. V., Reid, A., Wood, P., Finch, J. G., Guy Finch, J., Parmar, J., Stirland, E., Gardner-Thorpe, J., Al-Muhktar, A., Peterson, M., Majeed, A., Bajwa, F. M., Martin, J., Choy, A., Tsang, A., Pore, N., Andrew, D. R., Al-Khyatt, W., Taylor, C., Bhandari, S., Subramanium, D., Toh, S. K. C., Carter, N. C., Tate, S., Pearce, B., Wainwright, D., Mercer, S. J., Knight, B., Vijay, V., Alagaratnam, S., Sinha, S., El-Hasani, S. S., Hussain, A. A., Bhattacharya, V., Kansal, N., Fasih, T., Jackson, C., Siddiqui, M. N., Chishti, I. A., Fordham, I. J., Siddiqui, Z., Bausbacher, H., Geogloma, I., Gurung, K., Tsavellas, G., Basynat, P., Shrestha, A. K., Basu, S., Chhabra, A., Harilingam, M., Rabie, M., Akhtar, M., Kumar, P., Jafferbhoy, S. F., Hussain, N., Raza, S., Haque, M., Alam, I., Aseem, R., Patel, S., Asad, M., Booth, M. I., Ball, W. R., Wood, C. P. J., Pinho-Gomes, A. C., Kausar, A., Obeidallah, M. R., Varghase, J., Lodhia, J., Bradley, D., Rengifo, C., Lindsay, D., Gopalswamy, S., Finlay, I., Wardle, S., Bullen, N., Iftikhar, S. Y., Awan, A., Ahmed, J., Leeder, P., Fusai, G., Bond-Smith, G., Psica, A., Puri, Y., Hou, D., Noble, F., Szentpali, K., Broadhurst, J., Date, R., Hossack, M. R., Goh, Y. L., Turner, P., Shetty, V., Riera, M., Macano, C. A. W., Sukha, A., Preston, S. R., Hoban, J. R., Puntis, D. J., Williams, S. V., Krysztopik, R., Kynaston, J., Batt, J., Doe, M., Goscimski, A., Jones, G. H., Hall, C., Carty, N., Panteleimonitis, S., Gunasekera, R. T., Sheel, A. R. G., Lennon, H., Hindley, C., Reddy, M., Kenny, R., Elkheir, N., Mcglone, E. R., Rajaganeshan, R., Hancorn, K., Hargreaves, A., Prasad, R., Longbotham, D. A., Vijayanand, D., Wijetunga, I., Ziprin, P., Nicolay, C. R., Yeldham, G., Read, E., Gossage, J. A., Rolph, R. C., Ebied, H., Phull, M., Khan, M. A., Popplewell, M., Kyriakidis, D., Henley, N., Packer, J. R., Derbyshire, L., Porter, J., Appleton, S., Farouk, M., Basra, M., Jennings, N. A., Ali, S., Kanakala, V., Ali, H., Lane, R., Dickson-Lowe, R., Zarsadias, P., Mirza, D., Puig, S., Al Amari, K., Vijayan, D., Sutcliffe, R., Marudanayagam, R., Hamady, Z., Prasad, A. R., Patel, A., Durkin, D., Kaur, P., Bowen, L., Byrne, J. P., Pearson, K. L., Delisle, T. G., Davies, J., Tomlinson, M. A., Johnpulle, M. A., Slawinski, C., Macdonald, A., Nicholson, J., Newton, K., Mbuvi, J., Farooq, A., Mothe, B. S., Zafrani, Z., Brett, D., Francombe, J., Barnes, J., Cheung, M., Al-Bahrani, A. Z., Preziosi, G., Urbonas, T., Alberts, J., Mallik, M., Patel, K., Segaran, A., Doulias, T., Sufi, P. A., Yao, C., Pollock, S., Manzelli, A., Wajed, S., Kourkulos, M., Pezzuto, R., Wadley, M., Hamilton, E., Jaunoo, S., Padwick, R., Sayegh, M., Newton, R. C., Hebbar, M., Farag, S. F., Spearman, J., Hamdan, M. F., D'Costa, C., Blane, C., Giles, M., Peter, M. B., Hirst, N. A., Hossain, T., Pannu, A., El-Dhuwaib, Y., Morrison, T. E. M., Taylor, G. W., Thompson, R. L. E., Mccune, K., Loughlin, P., Lawther, R., Byrnes, C. K., Simpson, D. J., Mawhinney, A., Warren, C., Mckay, D., Mcilmunn, C., Martin, S., Macartney, M., Diamond, T., Davey, P., Jones, C., Clements, J. M., Digney, R., Chan, W. M., Mccain, S., Gull, S., Janeczko, A., Dorrian, E., Harris, A., Dawson, S., Johnston, D., Mcaree, B., Ghareeb, E., Thomas, G., Connelly, M., Mckenzie, S., Cieplucha, K., Spence, G., Campbell, W., Hooks, G., Bradley, N., Hill, A. D. K., Cassidy, J. T., Boland, M., Burke, P., Nally, D. M., Khogali, E., Shabo, W., Iskandar, E., Mcentee, G. P., O'Neill, M. A., Peirce, C., Lyons, E. M., O'Sullivan, A. W., Thakkar, R., Carroll, P., Ivanovski, I., Balfe, P., Lee, M., Winter, D. C., Kelly, M. E., Hoti, E., Maguire, D., Karunakaran, P., Geoghegan, J. G., Mcdermott, F., Martin, S. T., Cross, K. S., Cooke, F., Zeeshan, S., Murphy, J. O., Mealy, K., Mohan, H. M., Nedujchelyn, Y., Ullah, M. F., Ahmed, I., Giovinazzo, F., Milburn, J., Prince, S., Brooke, E., Buchan, J., Khalil, A. M., Vaughan, E. M., Ramage, M. I., Aldridge, R. C., Gibson, S., Nicholson, G. A., Vass, D. G., Grant, A. J., Holroyd, D. J., Jones, M. A., Sutton, C. M. L. R., O'Dwyer, P., Nilsson, F., Weber, B., Williamson, T. K., Lalla, K., Bryant, A., Carter, C. R., Forrest, C. R., Hunter, D. I., Nassar, A. H., Orizu, M. N., Knight, K., Qandeel, H., Suttie, S., Belding, R., Mcclarey, A., Boyd, A. T., Guthrie, G. J. K., Lim, P. J., Luhmann, A., Watson, A. J. M., Richards, C. H., Nicol, L., Madurska, M., Harrison, E., Boyce, K. M., Roebuck, A., Ferguson, G., Pati, P., Wilson, M. S. J., Dalgaty, F., Fothergill, L., Driscoll, P. J., Mozolowski, K. L., Banwell, V., Bennett, S. P., Rogers, P. N., Skelly, B. L., Rutherford, C. L., Mirza, A. K., Lazim, T., Lim, H. C. C., Duke, D., Ahmed, T., Beasley, W. D., Wilkinson, M. D., Maharaj, G., Malcolm, C., Brown, T. H., Al-Sarireh, B., Shingler, G. M., Mowbray, N., Radwan, R., Morcous, P., Wood, S., Kadhim, A., Stewart, D. J., Baker, A. L., Tanner, N., Shenoy, H., Hafiz, S., De Marchi, J. A., Singh-Ranger, D., Hisham, E., Ainley, P., O'Neill, S., Terrace, J., Napetti, S., Hopwood, B., Rhys, T., Downing, J., Kanavati, O., Coats, M., Aleksandrov, D., Kallaway, C., Yahya, S., Templeton, A., Trotter, M., Lo, C., Dhillon, A., Heywood, N., Aawsaj, Y., Hamdan, A., Reece-Bolton, O., Mcguigan, A., Shahin, Y., Aymon, Luther, A. A., Nicholson, J. A., Rajendran, I., Boal, M., and Ritchie, J.

Subjects
Adult, Male, operative difficulty, medicine.medical_specialty, medicine.medical_treatment, Difficulty grading, difficult cholecystectomy, predictive score, surgery, laparoscopic, cholecystectomy, Surgical planning, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Preoperative Care, Humans, Medicine, Laparoscopic cholecystectomy, Framingham Risk Score, business.industry, General surgery, Reproducibility of Results, Middle Aged, medicine.disease, Pre operative, Single surgeon, Cholecystectomy, Laparoscopic, ROC Curve, 030220 oncology & carcinogenesis, Multivariate Analysis, Cholecystitis, Female, 030211 gastroenterology & hepatology, Surgery, Cholecystectomy, business, Abdominal surgery
Abstract

The prediction of a difficult cholecystectomy has traditionally been based on certain pre-operative clinical and imaging factors. Most of the previous literature reported small patient cohorts and have not used an objective measure of operative difficulty. The aim of this study was to develop a pre-operative score to predict difficult cholecystectomy, as defined by a validated intra-operative difficulty grading scale. Two cohorts from prospectively maintained databases of patients who underwent laparoscopic cholecystectomy were analysed: the CholeS Study (8755 patients) and a single surgeon series (4089 patients). Factors potentially predictive of difficulty were correlated to the Nassar intra-operative difficulty scale. A multivariable binary logistic regression analysis was then used to identify factors that were independently associated with difficult laparoscopic cholecystectomy, defined as operative difficulty grades 3 to 5. The resulting model was then converted to a risk score, and validated on both internal and external datasets. Increasing age and ASA classification, male gender, diagnosis of CBD stone or cholecystitis, thick-walled gallbladders, CBD dilation, use of pre-operative ERCP and non-elective operations were found to be significant independent predictors of difficult cases. A risk score based on these factors returned an area under the ROC curve of 0.789 (95% CI 0.773–0.806, p

Published
2019

15. Effects of extreme meteorological conditions in 2018 on European methane emissions estimated using atmospheric inversions

Author

Thompson, R. L., Groot Zwaaftink, C. D., Brunner, D., Tsuruta, A., Aalto, T., Raivonen, M., Crippa, M., Solazzo, E., Guizzardi, D., Regnier, P., Maisonnier, M., Institute for Atmospheric and Earth System Research (INAR), and Micrometeorology and biogeochemical cycles

Subjects
WETLANDS, CH4, 010504 meteorology & atmospheric sciences, methane, SCHEME, General Mathematics, emissions, General Engineering, anomaly, General Physics and Astronomy, Articles, 010501 environmental sciences, 114 Physical sciences, 01 natural sciences, LANDFILL, Europe, MODEL, 13. Climate action, GROWTH, Seasons, atmospheric inversion, Research Articles, 0105 earth and related environmental sciences
Abstract

The effect of the 2018 extreme meteorological conditions in Europe on methane (CH4) emissions is examined using estimates from four atmospheric inversions calculated for the period 2005–2018. For most of Europe, we find no anomaly in 2018 compared to the 2005–2018 mean. However, we find a positive anomaly for the Netherlands in April, which coincided with positive temperature and soil moisture anomalies suggesting an increase in biogenic sources. We also find a negative anomaly for the Netherlands for September–October, which coincided with a negative anomaly in soil moisture, suggesting a decrease in soil sources. In addition, we find a positive anomaly for Serbia in spring, summer and autumn, which coincided with increases in temperature and soil moisture, again suggestive of changes in biogenic sources, and the annual emission for 2018 was 33 ± 38% higher than the 2005–2017 mean. These results indicate that CH4emissions from areas where the natural source is thought to be relatively small can still vary due to meteorological conditions. At the European scale though, the degree of variability over 2005–2018 was small, and there was negligible impact on the annual CH4emissions in 2018 despite the extreme meteorological conditions.This article is part of a discussion meeting issue ‘Rising methane: is warming feeding warming? (part 2)’.

Published
2021

18. Magnitude and Uncertainty of Nitrous Oxide Emissions From North America Based on Bottom‐Up and Top‐Down Approaches: Informing Future Research and National Inventories

Author

Xu, R., primary, Tian, H., additional, Pan, N., additional, Thompson, R. L., additional, Canadell, J. G., additional, Davidson, E. A., additional, Nevison, C., additional, Winiwarter, W., additional, Shi, H., additional, Pan, S., additional, Chang, J., additional, Ciais, P., additional, Dangal, S. R. S., additional, Ito, A., additional, Jackson, R. B., additional, Joos, F., additional, Lauerwald, R., additional, Lienert, S., additional, Maavara, T., additional, Millet, D. B., additional, Raymond, P. A., additional, Regnier, P., additional, Tubiello, F. N., additional, Vuichard, N., additional, Wells, K. C., additional, Wilson, C., additional, Yang, J., additional, Yao, Y., additional, Zaehle, S., additional, and Zhou, F., additional

Published
2021
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25. Additional file 1 of A single column separation method for barium isotope analysis of geologic and hydrologic materials with complex matrices

Author

Matecha, R. M., Capo, R. C., Stewart, B. W., Thompson, R. L., and Hakala, J. A.

Abstract

Additional file 1: Table S1. Information on samples used for column calibration experiments. Table S2. Thermo Element® ICP-MS signal intensity (in counts per second) for a column calibration using 2.0 N HCl for the entire elution of a dissolved silicate volcanic rock. Table S3. Thermo Element® ICP-MS signal intensity (in counts per second) for a column calibration using 2.5 N HCl for the entire elution of a dissolved silicate volcanic rock. Table S4. Thermo Element® ICP-MS signal intensities (in counts per second) for a column calibration using 2.5 N HCl for the first 20 mL, and 3.0 N HNO3 for the remaining elution of a produced water sample with 0.5 μg of La and Ce added. Table S5. Thermo Element® ICP-MS signal intensities (in counts per second) for a column calibration using 2.5 N HCl for the first 20 mL, and 2.0 N HNO3 for the remaining elution of dissolved freshwater mussel shell calcium carbonate. Figure S1. Examples of column matrix separation for major elements, Ba, and isobaric interferents La and Ce for a volcanic silicate sample using the BIO-RAD Poly-Prep® gravity flow ion exchange columns described in the manuscript. Figure S2. Examples of column matrix separation of Ba from isobaric interferents La and Ce for a produced water sample (a) and calcium carbonate sample (b) using the BIO-RAD Poly-Prep® gravity flow ion exchange columns described in the manuscript.

Published
2021
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28. Permafrost Region Greenhouse Gas Budgets Suggest a Weak CO2Sink and CH4and N2O Sources, But Magnitudes Differ Between Top‐Down and Bottom‐Up Methods

Author

Hugelius, G., Ramage, J., Burke, E., Chatterjee, A., Smallman, T. L., Aalto, T., Bastos, A., Biasi, C., Canadell, J. G., Chandra, N., Chevallier, F., Ciais, P., Chang, J., Feng, L., Jones, M. W., Kleinen, T., Kuhn, M., Lauerwald, R., Liu, J., López‐Blanco, E., Luijkx, I. T., Marushchak, M. E., Natali, S. M., Niwa, Y., Olefeldt, D., Palmer, P. I., Patra, P. K., Peters, W., Potter, S., Poulter, B., Rogers, B. M., Riley, W. J., Saunois, M., Schuur, E. A. G., Thompson, R. L., Treat, C., Tsuruta, A., Turetsky, M. R., Virkkala, A.‐M., Voigt, C., Watts, J., Zhu, Q., and Zheng, B.

Abstract

Large stocks of soil carbon (C) and nitrogen (N) in northern permafrost soils are vulnerable to remobilization under climate change. However, there are large uncertainties in present‐day greenhouse gas (GHG) budgets. We compare bottom‐up (data‐driven upscaling and process‐based models) and top‐down (atmospheric inversion models) budgets of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) as well as lateral fluxes of C and N across the region over 2000–2020. Bottom‐up approaches estimate higher land‐to‐atmosphere fluxes for all GHGs. Both bottom‐up and top‐down approaches show a sink of CO2in natural ecosystems (bottom‐up: −29 (−709, 455), top‐down: −587 (−862, −312) Tg CO2‐C yr−1) and sources of CH4(bottom‐up: 38 (22, 53), top‐down: 15 (11, 18) Tg CH4‐C yr−1) and N2O (bottom‐up: 0.7 (0.1, 1.3), top‐down: 0.09 (−0.19, 0.37) Tg N2O‐N yr−1). The combined global warming potential of all three gases (GWP‐100) cannot be distinguished from neutral. Over shorter timescales (GWP‐20), the region is a net GHG source because CH4dominates the total forcing. The net CO2sink in Boreal forests and wetlands is largely offset by fires and inland water CO2emissions as well as CH4emissions from wetlands and inland waters, with a smaller contribution from N2O emissions. Priorities for future research include the representation of inland waters in process‐based models and the compilation of process‐model ensembles for CH4and N2O. Discrepancies between bottom‐up and top‐down methods call for analyses of how prior flux ensembles impact inversion budgets, more and well‐distributed in situ GHG measurements and improved resolution in upscaling techniques. The northern permafrost region covers large areas and stores very large amounts of carbon and nitrogen in soils and sediments. With climate change, there is concern that thawing permafrost will release greenhouse gases into the atmosphere, shifting the region from long‐term cooling of the global climate to a net warming effect. In this study, we used different techniques to assess the greenhouse gas budgets of carbon dioxide, methane and nitrous oxide for the time period 2000‒2020. We find that the region is a net sink of carbon dioxide, mainly in boreal forests and wetlands, while carbon dioxide is emitted from inland waters and fires affecting both forest and tundra. Lakes and wetlands are strong sources of methane, which contributes to warm the climate significantly, especially over shorter timescales. Nitrous oxide is emitted at low rates across the region, with a relatively limited impact on climate. In summary, the climate warming from the northern permafrost region is likely close to neutral when calculated over a 100 years time window, but it warms the climate when calculated over a 20 years time window. The northern terrestrial permafrost region was a weak annual CO2sink and stable source of CH4and N2O during the time period 2000–2020The global warming potential is indistinguishable from neutral over a 100 years time period but a net source of warming over a 20 year periodBottom‐up and top‐down methods yield different magnitudes of estimates that cannot be fully reconciled The northern terrestrial permafrost region was a weak annual CO2sink and stable source of CH4and N2O during the time period 2000–2020 The global warming potential is indistinguishable from neutral over a 100 years time period but a net source of warming over a 20 year period Bottom‐up and top‐down methods yield different magnitudes of estimates that cannot be fully reconciled

Published
2024
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29. Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000–17

Author

Deshpande, A. (Aniruddha), Miller-Petrie, M. K. (Molly K.), Lindstedt, P. A. (Paulina A.), Baumann, M. M. (Mathew M.), Johnson, K. B. (Kimberly B.), Blacker, B. F. (Brigette F.), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abdollahpour, I. (Ibrahim), Abegaz, K. H. (Kedir Hussein), Abejie, A. N. (Ayenew Negesse), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abualhasan, A. (Ahmed), Accrombessi, M. M. (Manfred Mario Kokou), Adamu, A. A. (Abdu A.), Adebayo, O. M. (Oladimeji M.), Adedeji, I. A. (Isaac Akinkunmi), Adedoyin, R. A. (Rufus Adesoji), Adekanmbi, V. (Victor), Adetokunboh, O. O. (Olatunji O.), Adhikari, T. B. (Tara Ballav), Afarideh, M. (Mohsen), Agudelo-Botero, M. (Marcela), Ahmadi, M. (Mehdi), Ahmadi, K. (Keivan), Ahmed, M. B. (Muktar Beshir), Ahmed, A. E. (Anwar E.), Akalu, T. Y. (Temesgen Yihunie), Akanda, A. S. (Ali S.), Alahdab, F. (Fares), Al-Aly, Z. (Ziyad), Alam, S. (Samiah), Alam, N. (Noore), Alamene, G. M. (Genet Melak), Alanzi, T. M. (Turki M.), Albright, J. (James), Albujeer, A. (Ammar), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Alebel, A. (Animut), Alemu, Z. A. (Zewdie Aderaw), Ali, M. (Muhammad), Alijanzadeh, M. (Mehran), Alipour, V. (Vahid), Aljunid, S. M. (Syed Mohamed), Almasi, A. (Ali), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alvis-Guzman, N. (Nelson), Alvis-Zakzuk, N. J. (Nelson J.), Amini, S. (Saeed), Amit, A. M. (Arianna Maever L.), Amul, G. G. (Gianna Gayle Herrera), Andrei, C. L. (Catalina Liliana), Anjomshoa, M. (Mina), Ansariadi, A. (Ansariadi), Antonio, C. A. (Carl Abelardo T.), Antony, B. (Benny), Antriyandarti, E. (Ernoiz), Arabloo, J. (Jalal), Aref, H. M. (Hany Mohamed Amin), Aremu, O. (Olatunde), Armoon, B. (Bahram), Arora, A. (Amit), Aryal, K. K. (Krishna K.), Arzani, A. (Afsaneh), Asadi-Aliabadi, M. (Mehran), Asmelash, D. (Daniel), Atalay, H. T. (Hagos Tasew), Athari, S. M. (Seyyede Masoume), Athari, S. S. (Seyyed Shamsadin), Atre, S. R. (Sachin R.), Ausloos, M. (Marcel), Awasthi, S. (Shally), Awoke, N. (Nefsu), Quintanilla, B. P. (Beatriz Paulina Ayala), Ayano, G. (Getinet), Ayanore, M. A. (Martin Amogre), Aynalem, Y. A. (Yared Asmare), Azari, S. (Samad), Azman, A. S. (Andrew S.), Babaee, E. (Ebrahim), Badawi, A. (Alaa), Bagherzadeh, M. (Mojtaba), Bakkannavar, S. M. (Shankar M.), Balakrishnan, S. (Senthilkumar), Banach, M. (Maciej), Banoub, J. A. (Joseph Adel Mattar), Barac, A. (Aleksandra), Barboza, M. A. (Miguel A.), Barnighausen, T. W. (Till Winfried), Basu, S. (Sanjay), . (), Bayati, M. (Mohsen), Bedi, N. (Neeraj), Beheshti, M. (Mahya), Behzadifar, M. (Meysam), Behzadifar, M. (Masoud), Ramirez, D. F. (Diana Fernanda Bejarano), Bell, M. L. (Michelle L.), Bennett, D. A. (Derrick A.), Benzian, H. (Habib), Berbada, D. A. (Dessalegn Ajema), Bernstein, R. S. (Robert S.), Bhat, A. G. (Anusha Ganapati), Bhattacharyya, K. (Krittika), Bhaumik, S. (Soumyadeep), Bhutta, Z. A. (Zulfiqar A.), Bijani, A. (Ali), Bikbov, B. (Boris), Bin Sayeed, M. S. (Muhammad Shahdaat), Biswas, R. K. (Raaj Kishore), Bohlouli, S. (Somayeh), Boufous, S. (Soufiane), Brady, O. J. (Oliver J.), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Britton, G. B. (Gabrielle B.), Brown, A. (Alexandria), Nagaraja, S. B. (Sharath Burugina), Butt, Z. A. (Zahid A.), Camera, L. A. (Luis Alberto), Campos-Nonato, I. R. (Ismael R.), Rincon, J. C. (Julio Cesar Campuzano), Cano, J. (Jorge), Car, J. (Josip), Cardenas, R. (Rosario), Carvalho, F. (Felix), Castaneda-Orjuela, C. A. (Carlos A.), Castro, F. (Franz), Cerin, E. (Ester), Chalise, B. (Binaya), Chattu, V. K. (Vijay Kumar), Chin, K. L. (Ken Lee), Christopher, D. J. (Devasahayam J.), Chu, D.-T. (Dinh-Toi), Cormier, N. M. (Natalie Maria), Costa, V. M. (Vera Marisa), Cromwell, E. A. (Elizabeth A.), Dadi, A. F. (Abel Fekadu Fekadu), Dahiru, T. (Tukur), Dahlawi, S. M. (Saad M. A.), Dandona, R. (Rakhi), Dandona, L. (Lalit), Dang, A. K. (Anh Kim), Daoud, F. (Farah), Darwesh, A. M. (Aso Mohammad), Darwish, A. H. (Amira Hamed), Daryani, A. (Ahmad), Das, J. K. (Jai K.), Das Gupta, R. (Rajat), Dash, A. P. (Aditya Prasad), Davila-Cervantes, C. A. (Claudio Alberto), Weaver, N. D. (Nicole Davis), De la Hoz, F. P. (Fernando Pio), De Neve, J.-W. (Jan-Walter), Demissie, D. B. (Dereje Bayissa), Demoz, G. T. (Gebre Teklemariam), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Desalew, A. (Assefa), Dharmaratne, S. D. (Samath Dhamminda), Dhillon, P. (Preeti), Dhimal, M. (Meghnath), Dhungana, G. P. (Govinda Prasad), Diaz, D. (Daniel), Dipeolu, I. O. (Isaac Oluwafemi), Dolecek, C. (Christiane), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duraes, A. R. (Andre Rodrigues), Edinur, H. A. (Hisham Atan), Effiong, A. (Andem), Eftekhari, A. (Aziz), El Nahas, N. (Nevine), Zaki, M. E. (Maysaa El Sayed), El Tantawi, M. (Maha), Elhabashy, H. R. (Hala Rashad), El-Jaafary, S. I. (Shaimaa, I), El-Khatib, Z. (Ziad), Elkout, H. (Hajer), Elsharkawy, A. (Aisha), Enany, S. (Shymaa), Endalew, D. A. (Daniel Adane), Eshrati, B. (Babak), Eskandarieh, S. (Sharareh), Etemadi, A. (Arash), Ezekannagha, O. (Oluchi), Faraon, E. J. (Emerito Jose A.), Fareed, M. (Mohammad), Faro, A. (Andre), Farzadfar, F. (Farshad), Fasil, A. F. (Alebachew Fasil), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fekadu, W. (Wubalem), Fentahun, N. (Netsanet), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Filip, I. (Irina), Fischer, F. (Florian), Flohr, C. (Carsten), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Foroutan, M. (Masoud), Franklin, R. C. (Richard Charles), Frostad, J. J. (Joseph Jon), Fukumoto, T. (Takeshi), Gad, M. M. (Mohamed M.), Garcia, G. M. (Gregory M.), Gatotoh, A. M. (Augustine Mwangi), Gayesa, R. T. (Reta Tsegaye), Gebremedhin, K. B. (Ketema Bizuwork), Geramo, Y. C. (Yilma Chisha Dea), Gesesew, H. A. (Hailay Abrha), Gezae, K. E. (Kebede Embaye), Ghashghaee, A. (Ahmad), Sherbaf, F. G. (Farzaneh Ghazi), Gill, T. K. (Tiffany K.), Gill, P. S. (Paramjit Singh), Ginindza, T. G. (Themba G.), Girmay, A. (Alem), Gizaw, Z. (Zemichael), Goodridge, A. (Amador), Gopalani, S. V. (Sameer Vali), Goulart, B. N. (Barbara Niegia Garcia), Goulart, A. C. (Alessandra C.), Grada, A. (Ayman), Green, M. S. (Manfred S.), Gubari, M. I. (Mohammed Ibrahim Mohialdeen), Gugnani, H. C. (Harish Chander), Guido, D. (Davide), Guimaraes, R. A. (Rafael Alves), Guo, Y. (Yuming), Gupta, R. (Rajeev), Gupta, R. (Rahul), Ha, G. H. (Giang Hai), Haagsma, J. A. (Juanita A.), Hafezi-Nejad, N. (Nima), Haile, D. H. (Dessalegn H.), Haile, M. T. (Michael Tamene), Hall, B. J. (Brian J.), Hamidi, S. (Samer), Handiso, D. W. (Demelash Woldeyohannes), Haririan, H. (Hamidreza), Hariyani, N. (Ninuk), Hasaballah, A. I. (Ahmed, I), Hasan, M. (Mehedi), Hasanzadeh, A. (Amir), Hassen, H. Y. (Hamid Yimam), Hayelom, D. H. (Desta Haftu), Hegazy, M. I. (Mohamed, I), Heibati, B. (Behzad), Heidari, B. (Behnam), Hendrie, D. (Delia), Henok, A. (Andualem), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), de Hidru, H. D. (Hagos Degefa), Hird, T. R. (Thomas R.), Hollerich, G. I. (Gillian, I), Hoogar, P. (Praveen), Hossain, N. (Naznin), Hosseinzadeh, M. (Mehdi), Househ, M. (Mowafa), Hu, G. (Guoqing), Humayun, A. (Ayesha), Hussain, S. A. (Syed Ather), Hussen, M. A. (Mamusha Aman A.), Ibitoye, S. E. (Segun Emmanuel), Ilesanmi, O. S. (Olayinka Stephen), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Iqbal, U. (Usman), Irvani, S. S. (Seyed Sina Naghibi), Islam, S. M. (Sheikh Mohammed Shariful), Ivers, R. Q. (Rebecca Q.), Iwu, C. J. (Chinwe Juliana), Jahanmehr, N. (Nader), Jakovljevic, M. (Mihajlo), Jalali, A. (Amir), Jayatilleke, A. U. (Achala Upendra), Jenabi, E. (Ensiyeh), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Jozwiak, J. J. (Jacek Jerzy), Kabir, A. (Ali), Kabir, Z. (Zubair), Kanchan, T. (Tanuj), Karch, A. (Andre), Karki, S. (Surendra), Kasaeian, A. (Amir), Kasahun, G. G. (Gebremicheal Gebreslassie), Kasaye, H. K. (Habtamu Kebebe), Kassa, G. G. (Gebrehiwot G.), Kassa, G. M. (Getachew Mullu), Kayode, G. A. (Gbenga A.), Kebede, M. M. (Mihiretu M.), Keiyoro, P. N. (Peter Njenga), Ketema, D. B. (Daniel Bekele), Khader, Y. S. (Yousef Saleh), Khafaie, M. A. (Morteza Abdullatif), Khalid, N. (Nauman), Khalilov, R. (Rovshan), Khan, E. A. (Ejaz Ahmad), Khan, J. (Junaid), Khan, N. (Nuruzzaman), Khatab, K. (Khaled), Khater, M. M. (Mona M.), Khater, A. M. (Amir M.), Khayamzadeh, M. (Maryam), Khazaei, M. (Mohammad), Khosravi, M. H. (Mohammad Hossein), Khubchandani, J. (Jagdish), Kiadaliri, A. (Ali), Kim, Y. J. (Yun Jin), Kimokoti, R. W. (Ruth W.), Kisa, S. (Sezer), Kisa, A. (Adnan), Kochhar, S. (Sonali), Kolola, T. (Tufa), Komaki, H. (Hamidreza), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Krishan, K. (Kewal), Defo, B. K. (Barthelemy Kuate), Kugbey, N. (Nuworza), Kumar, P. (Pushpendra), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kusuma, D. (Dian), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lal, A. (Aparna), Lal, D. K. (Dharmesh Kumar), Lam, H. (Hilton), Lami, F. H. (Faris Hasan), Lansingh, V. C. (Van Charles), Lasrado, S. (Savita), Lebedev, G. (Georgy), Lee, P. H. (Paul H.), LeGrand, K. E. (Kate E.), Leili, M. (Mostafa), Lenjebo, T. L. (Tsegaye Lolaso), Leshargie, C. T. (Cheru Tesema), Levine, A. J. (Aubrey J.), Lewycka, S. (Sonia), Li, S. (Shanshan), Linn, S. (Shai), Liu, S. (Shiwei), Lopez, J. C. (Jaifred Christian F.), Lopukhov, P. D. (Platon D.), Abd El Razek, M. M. (Muhammed Magdy), Prasad, D. R. (D. R. Mahadeshwara), Mahasha, P. W. (Phetole Walter), Mahotra, N. B. (Narayan B.), Majeed, A. (Azeem), Malekzadeh, R. (Reza), Malta, D. C. (Deborah Carvalho), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Martinez, G. (Gabriel), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Mathur, M. R. (Manu Raj), Mayala, B. K. (Benjamin K.), Mazidi, M. (Mohsen), McAlinden, C. (Colm), Meharie, B. G. (Birhanu Geta), Mehndiratta, M. M. (Man Mohan), Nasab, E. M. (Entezar Mehrabi), Mehta, K. M. (Kala M.), Mekonnen, T. (Teferi), Mekonnen, T. C. (Tefera Chane), Meles, G. G. (Gebrekiros Gebremichael), Meles, H. G. (Hagazi Gebre), Memiah, P. T. (Peter T. N.), Memish, Z. A. (Ziad A.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mereta, S. T. (Seid Tiku), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Metekiya, W. M. (Workua Mekonnen), Miazgowski, B. (Bartosz), Miller, T. R. (Ted R.), Mini, G. K. (G. K.), Mirrakhimov, E. M. (Erkin M.), Moazen, B. (Babak), Mohajer, B. (Bahram), Mohammad, Y. (Yousef), Mohammad, D. K. (Dara K.), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadibakhsh, R. (Roghayeh), Mohammed, S. (Shafiu), Mohammed, J. A. (Jemal Abdu), Mohammed, H. (Hassen), Mohebi, F. (Farnam), Mokdad, A. H. (Ali H.), Moodley, Y. (Yoshan), Moradi, M. (Masoud), Moradi, G. (Ghobad), Moradi-Joo, M. (Mohammad), Moraga, P. (Paula), Morales, L. (Linda), Mosapour, A. (Abbas), Mosser, J. F. (Jonathan F.), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Mozaffor, M. (Miliva), Munro, S. B. (Sandra B.), Muriithi, M. K. (Moses K.), Murray, C. J. (Christopher J. L.), Musa, K. I. (Kamarul Imran), Mustafa, G. (Ghulam), Muthupandian, S. (Saravanan), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naghavi, M. (Mohsen), Naik, G. (Gurudatta), Nangia, V. (Vinay), Nascimento, B. R. (Bruno Ramos), Nazari, J. (Javad), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Netsere, H. B. (Henok Biresaw), Ngunjiri, J. W. (Josephine W.), Nguyen, Q. P. (QuynhAnh P.), Nigatu, S. G. (Solomon Gedlu), Ningrum, D. N. (Dina Nur Anggraini), Nnaji, C. A. (Chukwudi A.), Nojomi, M. (Marzieh), Norheim, O. F. (Ole F.), Noubiap, J. J. (Jean Jacques), Oancea, B. (Bogdan), Ogbo, F. A. (Felix Akpojene), Oh, I.-H. (In-Hwan), Olagunju, A. T. (Andrew T.), Olusanya, J. O. (Jacob Olusegun), Olusanya, B. O. (Bolajoko Olubukunola), Onwujekwe, O. E. (Obinna E.), Ortega-Altamirano, D. V. (Doris, V), Osarenotor, O. (Osayomwanbo), Osei, F. B. (Frank B.), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakhale, S. (Smita), Pana, A. (Adrian), Park, E.-K. (Eun-Kee), Patel, S. K. (Sangram Kishor), Pathak, A. (Ashish), Patle, A. (Ajay), Paulos, K. (Kebreab), Pepito, V. C. (Veincent Christian Filipino), Perico, N. (Norberto), Pervaiz, A. (Aslam), Pescarini, J. M. (Julia Moreira), Pesudovs, K. (Konrad), Pham, H. Q. (Hai Quang), Pigott, D. M. (David M.), Pilgrim, T. (Thomas), Pirsaheb, M. (Meghdad), Poljak, M. (Mario), Pollock, I. (Ian), Postma, M. J. (Maarten J.), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Prada, S. I. (Sergio, I), Preotescu, L. (Liliana), Quintana, H. (Hedley), Rabiee, N. (Navid), Rabiee, M. (Mohammad), Radfar, A. (Amir), Rafiei, A. (Alireza), Rahim, F. (Fakher), Rahimi, S. (Siavash), Rahimi-Movaghar, V. (Vafa), Rahman, M. A. (Muhammad Aziz), Rahman, M. H. (Mohammad Hifz Ur), Rajati, F. (Fatemeh), Ranabhat, C. L. (Chhabi Lal), Rao, P. C. (Puja C.), Rasella, D. (Davide), Rath, G. K. (Goura Kishor), Rawaf, S. (Salman), Rawal, L. (Lal), Rawasia, W. F. (Wasiq Faraz), Remuzzi, G. (Giuseppe), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Riahi, S. M. (Seyed Mohammad), Ribeiro, A. I. (Ana Isabel), Rickard, J. (Jennifer), Roever, L. (Leonardo), Ronfani, L. (Luca), Rubagotti, E. (Enrico), Rubino, S. (Salvatore), Saad, A. M. (Anas M.), Sabour, S. (Siamak), Sadeghi, E. (Ehsan), Moghaddam, S. S. (Sahar Saeedi), Safari, Y. (Yahya), Sagar, R. (Rajesh), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salam, N. (Nasir), Saleem, A. (Ahsan), Salem, H. (Hosni), Salem, M. R. (Marwa Rashad), Salimi, Y. (Yahya), Salimzadeh, H. (Hamideh), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santos, I. S. (Itamar S.), Santric-Milicevic, M. M. (Milena M.), Sao Jose, B. P. (Bruno Piassi), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sarrafzadegan, N. (Nizal), Sartorius, B. (Benn), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Satpathy, M. (Maheswar), Sawhney, M. (Monika), Sayyah, M. (Mehdi), Sbarra, A. N. (Alyssa N.), Schaeffer, L. E. (Lauren E.), Schwebel, D. C. (David C.), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shafieesabet, A. (Azadeh), Shaheen, A. A. (Amira A.), Shahid, I. (Izza), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharma, R. (Rajesh), Sheikh, A. (Aziz), Shetty, B. S. (B. Suresh Kumar), Shiferaw, W. S. (Wondimeneh Shibabaw), Shigematsu, M. (Mika), Shin, J. I. (Jae Il), Shiri, R. (Rahman), Shirkoohi, R. (Reza), Shivakumar, K. M. (K. M.), Si, S. (Si), Siabani, S. (Soraya), Siddiqi, T. J. (Tariq Jamal), Silva, D. A. (Diego Augusto Santos), Singh, V. (Virendra), Singh, N. P. (Narinder Pal), Singh, B. B. (Balbir Bagicha Singh), Singh, J. A. (Jasvinder A.), Singh, A. (Ambrish), Sinha, D. N. (Dhirendra Narain), Sisay, M. M. (Malede Mequanent), Skiadaresi, E. (Eirini), Smith, D. L. (David L.), Filho, A. M. (Adauto Martins Soares), Sobhiyeh, M. R. (Mohammad Reza), Sokhan, A. (Anton), Soriano, J. B. (Joan B.), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Spurlock, E. E. (Emma Elizabeth), Sreeramareddy, C. T. (Chandrashekhar T.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Suleria, H. A. (Hafiz Ansar Rasul), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabuchi, T. (Takahiro), Tadesse, D. B. (Degena Bahrey), Tarigan, I. U. (Ingan Ukur), Taye, B. (Bineyam), Tefera, Y. M. (Yonatal Mesfin), Tehrani-Banihashemi, A. (Arash), Tekelemedhin, S. W. (Shishay Wahdey), Tekle, M. G. (Merhawi Gebremedhin), Temsah, M.-H. (Mohamad-Hani), Tesfay, B. E. (Berhe Etsay), Tesfay, F. H. (Fisaha Haile), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), ThekkePurakkal, A. S. (Akhil Soman), Thomas, N. (Nihal), Thompson, R. L. (Robert L.), Thomson, A. J. (Alan J.), Topor-Madry, R. (Roman), Tovani-Palone, M. R. (Marcos Roberto), Traini, E. (Eugenio), Ullah, I. (Irfan), Unnikrishnan, B. (Bhaskaran), Usman, M. S. (Muhammad Shariq), Uthman, O. A. (Olalekan A.), Uzochukwu, B. S. (Benjamin S. Chudi), Valdez, P. R. (Pascual R.), Varughese, S. (Santosh), Veisani, Y. (Yousef), Violante, F. S. (Francesco S.), Vollmer, S. (Sebastian), Whawariat, F. G. (Feleke Gebremeskel), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Wang, Y.-P. (Yuan-Pang), Wang, Y. (Yafeng), Wangdi, K. (Kinley), Weiss, D. J. (Daniel J.), Weldesamuel, G. T. (Girmay Teklay), Werkneh, A. A. (Adhena Ayaliew), Westerman, R. (Ronny), Wiangkham, T. (Taweewat), Wiens, K. E. (Kirsten E.), Wijeratne, T. (Tissa), Wiysonge, C. S. (Charles Shey), Wolde, H. F. (Haileab Fekadu), Wondafrash, D. Z. (Dawit Zewdu), Wonde, T. E. (Tewodros Eshete), Worku, G. T. (Getasew Taddesse), Yadollahpour, A. (Ali), Jabbari, S. H. (Seyed Hossein Yahyazadeh), Yamada, T. (Tomohide), Yaseri, M. (Mehdi), Yatsuya, H. (Hiroshi), Yeshaneh, A. (Alex), Yilma, M. T. (Mekdes Tigistu), Yip, P. (Paul), Yisma, E. (Engida), Yonemoto, N. (Naohiro), Younis, M. Z. (Mustafa Z.), Yousof, H. S. (Hebat-Allah Salah A.), Yu, C. (Chuanhua), Yusefzadeh, H. (Hasan), Zadey, S. (Siddhesh), Moghadam, T. Z. (Telma Zahirian), Zaidi, Z. (Zoubida), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zandian, H. (Hamed), Zar, H. J. (Heather J.), Zerfu, T. A. (Taddese Alemu), Zhang, Y. (Yunquan), Ziapour, A. (Arash), Zodpey, S. (Sanjay), Zuniga, Y. M. (Yves Miel H.), Hay, S. I. (Simon, I), Reiner, R. C. (Robert C., Jr.), Deshpande, A. (Aniruddha), Miller-Petrie, M. K. (Molly K.), Lindstedt, P. A. (Paulina A.), Baumann, M. M. (Mathew M.), Johnson, K. B. (Kimberly B.), Blacker, B. F. (Brigette F.), Abbastabar, H. (Hedayat), Abd-Allah, F. (Foad), Abdelalim, A. (Ahmed), Abdollahpour, I. (Ibrahim), Abegaz, K. H. (Kedir Hussein), Abejie, A. N. (Ayenew Negesse), Abreu, L. G. (Lucas Guimaraes), Abrigo, M. R. (Michael R. M.), Abualhasan, A. (Ahmed), Accrombessi, M. M. (Manfred Mario Kokou), Adamu, A. A. (Abdu A.), Adebayo, O. M. (Oladimeji M.), Adedeji, I. A. (Isaac Akinkunmi), Adedoyin, R. A. (Rufus Adesoji), Adekanmbi, V. (Victor), Adetokunboh, O. O. (Olatunji O.), Adhikari, T. B. (Tara Ballav), Afarideh, M. (Mohsen), Agudelo-Botero, M. (Marcela), Ahmadi, M. (Mehdi), Ahmadi, K. (Keivan), Ahmed, M. B. (Muktar Beshir), Ahmed, A. E. (Anwar E.), Akalu, T. Y. (Temesgen Yihunie), Akanda, A. S. (Ali S.), Alahdab, F. (Fares), Al-Aly, Z. (Ziyad), Alam, S. (Samiah), Alam, N. (Noore), Alamene, G. M. (Genet Melak), Alanzi, T. M. (Turki M.), Albright, J. (James), Albujeer, A. (Ammar), Alcalde-Rabanal, J. E. (Jacqueline Elizabeth), Alebel, A. (Animut), Alemu, Z. A. (Zewdie Aderaw), Ali, M. (Muhammad), Alijanzadeh, M. (Mehran), Alipour, V. (Vahid), Aljunid, S. M. (Syed Mohamed), Almasi, A. (Ali), Almasi-Hashiani, A. (Amir), Al-Mekhlafi, H. M. (Hesham M.), Altirkawi, K. A. (Khalid A.), Alvis-Guzman, N. (Nelson), Alvis-Zakzuk, N. J. (Nelson J.), Amini, S. (Saeed), Amit, A. M. (Arianna Maever L.), Amul, G. G. (Gianna Gayle Herrera), Andrei, C. L. (Catalina Liliana), Anjomshoa, M. (Mina), Ansariadi, A. (Ansariadi), Antonio, C. A. (Carl Abelardo T.), Antony, B. (Benny), Antriyandarti, E. (Ernoiz), Arabloo, J. (Jalal), Aref, H. M. (Hany Mohamed Amin), Aremu, O. (Olatunde), Armoon, B. (Bahram), Arora, A. (Amit), Aryal, K. K. (Krishna K.), Arzani, A. (Afsaneh), Asadi-Aliabadi, M. (Mehran), Asmelash, D. (Daniel), Atalay, H. T. (Hagos Tasew), Athari, S. M. (Seyyede Masoume), Athari, S. S. (Seyyed Shamsadin), Atre, S. R. (Sachin R.), Ausloos, M. (Marcel), Awasthi, S. (Shally), Awoke, N. (Nefsu), Quintanilla, B. P. (Beatriz Paulina Ayala), Ayano, G. (Getinet), Ayanore, M. A. (Martin Amogre), Aynalem, Y. A. (Yared Asmare), Azari, S. (Samad), Azman, A. S. (Andrew S.), Babaee, E. (Ebrahim), Badawi, A. (Alaa), Bagherzadeh, M. (Mojtaba), Bakkannavar, S. M. (Shankar M.), Balakrishnan, S. (Senthilkumar), Banach, M. (Maciej), Banoub, J. A. (Joseph Adel Mattar), Barac, A. (Aleksandra), Barboza, M. A. (Miguel A.), Barnighausen, T. W. (Till Winfried), Basu, S. (Sanjay), . (), Bayati, M. (Mohsen), Bedi, N. (Neeraj), Beheshti, M. (Mahya), Behzadifar, M. (Meysam), Behzadifar, M. (Masoud), Ramirez, D. F. (Diana Fernanda Bejarano), Bell, M. L. (Michelle L.), Bennett, D. A. (Derrick A.), Benzian, H. (Habib), Berbada, D. A. (Dessalegn Ajema), Bernstein, R. S. (Robert S.), Bhat, A. G. (Anusha Ganapati), Bhattacharyya, K. (Krittika), Bhaumik, S. (Soumyadeep), Bhutta, Z. A. (Zulfiqar A.), Bijani, A. (Ali), Bikbov, B. (Boris), Bin Sayeed, M. S. (Muhammad Shahdaat), Biswas, R. K. (Raaj Kishore), Bohlouli, S. (Somayeh), Boufous, S. (Soufiane), Brady, O. J. (Oliver J.), Briko, A. N. (Andrey Nikolaevich), Briko, N. I. (Nikolay Ivanovich), Britton, G. B. (Gabrielle B.), Brown, A. (Alexandria), Nagaraja, S. B. (Sharath Burugina), Butt, Z. A. (Zahid A.), Camera, L. A. (Luis Alberto), Campos-Nonato, I. R. (Ismael R.), Rincon, J. C. (Julio Cesar Campuzano), Cano, J. (Jorge), Car, J. (Josip), Cardenas, R. (Rosario), Carvalho, F. (Felix), Castaneda-Orjuela, C. A. (Carlos A.), Castro, F. (Franz), Cerin, E. (Ester), Chalise, B. (Binaya), Chattu, V. K. (Vijay Kumar), Chin, K. L. (Ken Lee), Christopher, D. J. (Devasahayam J.), Chu, D.-T. (Dinh-Toi), Cormier, N. M. (Natalie Maria), Costa, V. M. (Vera Marisa), Cromwell, E. A. (Elizabeth A.), Dadi, A. F. (Abel Fekadu Fekadu), Dahiru, T. (Tukur), Dahlawi, S. M. (Saad M. A.), Dandona, R. (Rakhi), Dandona, L. (Lalit), Dang, A. K. (Anh Kim), Daoud, F. (Farah), Darwesh, A. M. (Aso Mohammad), Darwish, A. H. (Amira Hamed), Daryani, A. (Ahmad), Das, J. K. (Jai K.), Das Gupta, R. (Rajat), Dash, A. P. (Aditya Prasad), Davila-Cervantes, C. A. (Claudio Alberto), Weaver, N. D. (Nicole Davis), De la Hoz, F. P. (Fernando Pio), De Neve, J.-W. (Jan-Walter), Demissie, D. B. (Dereje Bayissa), Demoz, G. T. (Gebre Teklemariam), Denova-Gutierrez, E. (Edgar), Deribe, K. (Kebede), Desalew, A. (Assefa), Dharmaratne, S. D. (Samath Dhamminda), Dhillon, P. (Preeti), Dhimal, M. (Meghnath), Dhungana, G. P. (Govinda Prasad), Diaz, D. (Daniel), Dipeolu, I. O. (Isaac Oluwafemi), Dolecek, C. (Christiane), Doyle, K. E. (Kerrie E.), Dubljanin, E. (Eleonora), Duraes, A. R. (Andre Rodrigues), Edinur, H. A. (Hisham Atan), Effiong, A. (Andem), Eftekhari, A. (Aziz), El Nahas, N. (Nevine), Zaki, M. E. (Maysaa El Sayed), El Tantawi, M. (Maha), Elhabashy, H. R. (Hala Rashad), El-Jaafary, S. I. (Shaimaa, I), El-Khatib, Z. (Ziad), Elkout, H. (Hajer), Elsharkawy, A. (Aisha), Enany, S. (Shymaa), Endalew, D. A. (Daniel Adane), Eshrati, B. (Babak), Eskandarieh, S. (Sharareh), Etemadi, A. (Arash), Ezekannagha, O. (Oluchi), Faraon, E. J. (Emerito Jose A.), Fareed, M. (Mohammad), Faro, A. (Andre), Farzadfar, F. (Farshad), Fasil, A. F. (Alebachew Fasil), Fazlzadeh, M. (Mehdi), Feigin, V. L. (Valery L.), Fekadu, W. (Wubalem), Fentahun, N. (Netsanet), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fernandes, E. (Eduarda), Filip, I. (Irina), Fischer, F. (Florian), Flohr, C. (Carsten), Foigt, N. A. (Nataliya A.), Folayan, M. O. (Morenike Oluwatoyin), Foroutan, M. (Masoud), Franklin, R. C. (Richard Charles), Frostad, J. J. (Joseph Jon), Fukumoto, T. (Takeshi), Gad, M. M. (Mohamed M.), Garcia, G. M. (Gregory M.), Gatotoh, A. M. (Augustine Mwangi), Gayesa, R. T. (Reta Tsegaye), Gebremedhin, K. B. (Ketema Bizuwork), Geramo, Y. C. (Yilma Chisha Dea), Gesesew, H. A. (Hailay Abrha), Gezae, K. E. (Kebede Embaye), Ghashghaee, A. (Ahmad), Sherbaf, F. G. (Farzaneh Ghazi), Gill, T. K. (Tiffany K.), Gill, P. S. (Paramjit Singh), Ginindza, T. G. (Themba G.), Girmay, A. (Alem), Gizaw, Z. (Zemichael), Goodridge, A. (Amador), Gopalani, S. V. (Sameer Vali), Goulart, B. N. (Barbara Niegia Garcia), Goulart, A. C. (Alessandra C.), Grada, A. (Ayman), Green, M. S. (Manfred S.), Gubari, M. I. (Mohammed Ibrahim Mohialdeen), Gugnani, H. C. (Harish Chander), Guido, D. (Davide), Guimaraes, R. A. (Rafael Alves), Guo, Y. (Yuming), Gupta, R. (Rajeev), Gupta, R. (Rahul), Ha, G. H. (Giang Hai), Haagsma, J. A. (Juanita A.), Hafezi-Nejad, N. (Nima), Haile, D. H. (Dessalegn H.), Haile, M. T. (Michael Tamene), Hall, B. J. (Brian J.), Hamidi, S. (Samer), Handiso, D. W. (Demelash Woldeyohannes), Haririan, H. (Hamidreza), Hariyani, N. (Ninuk), Hasaballah, A. I. (Ahmed, I), Hasan, M. (Mehedi), Hasanzadeh, A. (Amir), Hassen, H. Y. (Hamid Yimam), Hayelom, D. H. (Desta Haftu), Hegazy, M. I. (Mohamed, I), Heibati, B. (Behzad), Heidari, B. (Behnam), Hendrie, D. (Delia), Henok, A. (Andualem), Herteliu, C. (Claudiu), Heydarpour, F. (Fatemeh), de Hidru, H. D. (Hagos Degefa), Hird, T. R. (Thomas R.), Hollerich, G. I. (Gillian, I), Hoogar, P. (Praveen), Hossain, N. (Naznin), Hosseinzadeh, M. (Mehdi), Househ, M. (Mowafa), Hu, G. (Guoqing), Humayun, A. (Ayesha), Hussain, S. A. (Syed Ather), Hussen, M. A. (Mamusha Aman A.), Ibitoye, S. E. (Segun Emmanuel), Ilesanmi, O. S. (Olayinka Stephen), Ilic, M. D. (Milena D.), Imani-Nasab, M. H. (Mohammad Hasan), Iqbal, U. (Usman), Irvani, S. S. (Seyed Sina Naghibi), Islam, S. M. (Sheikh Mohammed Shariful), Ivers, R. Q. (Rebecca Q.), Iwu, C. J. (Chinwe Juliana), Jahanmehr, N. (Nader), Jakovljevic, M. (Mihajlo), Jalali, A. (Amir), Jayatilleke, A. U. (Achala Upendra), Jenabi, E. (Ensiyeh), Jha, R. P. (Ravi Prakash), Jha, V. (Vivekanand), Ji, J. S. (John S.), Jonas, J. B. (Jost B.), Jozwiak, J. J. (Jacek Jerzy), Kabir, A. (Ali), Kabir, Z. (Zubair), Kanchan, T. (Tanuj), Karch, A. (Andre), Karki, S. (Surendra), Kasaeian, A. (Amir), Kasahun, G. G. (Gebremicheal Gebreslassie), Kasaye, H. K. (Habtamu Kebebe), Kassa, G. G. (Gebrehiwot G.), Kassa, G. M. (Getachew Mullu), Kayode, G. A. (Gbenga A.), Kebede, M. M. (Mihiretu M.), Keiyoro, P. N. (Peter Njenga), Ketema, D. B. (Daniel Bekele), Khader, Y. S. (Yousef Saleh), Khafaie, M. A. (Morteza Abdullatif), Khalid, N. (Nauman), Khalilov, R. (Rovshan), Khan, E. A. (Ejaz Ahmad), Khan, J. (Junaid), Khan, N. (Nuruzzaman), Khatab, K. (Khaled), Khater, M. M. (Mona M.), Khater, A. M. (Amir M.), Khayamzadeh, M. (Maryam), Khazaei, M. (Mohammad), Khosravi, M. H. (Mohammad Hossein), Khubchandani, J. (Jagdish), Kiadaliri, A. (Ali), Kim, Y. J. (Yun Jin), Kimokoti, R. W. (Ruth W.), Kisa, S. (Sezer), Kisa, A. (Adnan), Kochhar, S. (Sonali), Kolola, T. (Tufa), Komaki, H. (Hamidreza), Kosen, S. (Soewarta), Koul, P. A. (Parvaiz A.), Koyanagi, A. (Ai), Krishan, K. (Kewal), Defo, B. K. (Barthelemy Kuate), Kugbey, N. (Nuworza), Kumar, P. (Pushpendra), Kumar, G. A. (G. Anil), Kumar, M. (Manasi), Kusuma, D. (Dian), La Vecchia, C. (Carlo), Lacey, B. (Ben), Lal, A. (Aparna), Lal, D. K. (Dharmesh Kumar), Lam, H. (Hilton), Lami, F. H. (Faris Hasan), Lansingh, V. C. (Van Charles), Lasrado, S. (Savita), Lebedev, G. (Georgy), Lee, P. H. (Paul H.), LeGrand, K. E. (Kate E.), Leili, M. (Mostafa), Lenjebo, T. L. (Tsegaye Lolaso), Leshargie, C. T. (Cheru Tesema), Levine, A. J. (Aubrey J.), Lewycka, S. (Sonia), Li, S. (Shanshan), Linn, S. (Shai), Liu, S. (Shiwei), Lopez, J. C. (Jaifred Christian F.), Lopukhov, P. D. (Platon D.), Abd El Razek, M. M. (Muhammed Magdy), Prasad, D. R. (D. R. Mahadeshwara), Mahasha, P. W. (Phetole Walter), Mahotra, N. B. (Narayan B.), Majeed, A. (Azeem), Malekzadeh, R. (Reza), Malta, D. C. (Deborah Carvalho), Mamun, A. A. (Abdullah A.), Manafi, N. (Navid), Mansournia, M. A. (Mohammad Ali), Mapoma, C. C. (Chabila Christopher), Martinez, G. (Gabriel), Martini, S. (Santi), Martins-Melo, F. R. (Francisco Rogerlandio), Mathur, M. R. (Manu Raj), Mayala, B. K. (Benjamin K.), Mazidi, M. (Mohsen), McAlinden, C. (Colm), Meharie, B. G. (Birhanu Geta), Mehndiratta, M. M. (Man Mohan), Nasab, E. M. (Entezar Mehrabi), Mehta, K. M. (Kala M.), Mekonnen, T. (Teferi), Mekonnen, T. C. (Tefera Chane), Meles, G. G. (Gebrekiros Gebremichael), Meles, H. G. (Hagazi Gebre), Memiah, P. T. (Peter T. N.), Memish, Z. A. (Ziad A.), Mendoza, W. (Walter), Menezes, R. G. (Ritesh G.), Mereta, S. T. (Seid Tiku), Meretoja, T. J. (Tuomo J.), Mestrovic, T. (Tomislav), Metekiya, W. M. (Workua Mekonnen), Miazgowski, B. (Bartosz), Miller, T. R. (Ted R.), Mini, G. K. (G. K.), Mirrakhimov, E. M. (Erkin M.), Moazen, B. (Babak), Mohajer, B. (Bahram), Mohammad, Y. (Yousef), Mohammad, D. K. (Dara K.), Mezerji, N. M. (Naser Mohammad Gholi), Mohammadibakhsh, R. (Roghayeh), Mohammed, S. (Shafiu), Mohammed, J. A. (Jemal Abdu), Mohammed, H. (Hassen), Mohebi, F. (Farnam), Mokdad, A. H. (Ali H.), Moodley, Y. (Yoshan), Moradi, M. (Masoud), Moradi, G. (Ghobad), Moradi-Joo, M. (Mohammad), Moraga, P. (Paula), Morales, L. (Linda), Mosapour, A. (Abbas), Mosser, J. F. (Jonathan F.), Mouodi, S. (Simin), Mousavi, S. M. (Seyyed Meysam), Mozaffor, M. (Miliva), Munro, S. B. (Sandra B.), Muriithi, M. K. (Moses K.), Murray, C. J. (Christopher J. L.), Musa, K. I. (Kamarul Imran), Mustafa, G. (Ghulam), Muthupandian, S. (Saravanan), Naderi, M. (Mehdi), Nagarajan, A. J. (Ahamarshan Jayaraman), Naghavi, M. (Mohsen), Naik, G. (Gurudatta), Nangia, V. (Vinay), Nascimento, B. R. (Bruno Ramos), Nazari, J. (Javad), Ndwandwe, D. E. (Duduzile Edith), Negoi, I. (Ionut), Netsere, H. B. (Henok Biresaw), Ngunjiri, J. W. (Josephine W.), Nguyen, Q. P. (QuynhAnh P.), Nigatu, S. G. (Solomon Gedlu), Ningrum, D. N. (Dina Nur Anggraini), Nnaji, C. A. (Chukwudi A.), Nojomi, M. (Marzieh), Norheim, O. F. (Ole F.), Noubiap, J. J. (Jean Jacques), Oancea, B. (Bogdan), Ogbo, F. A. (Felix Akpojene), Oh, I.-H. (In-Hwan), Olagunju, A. T. (Andrew T.), Olusanya, J. O. (Jacob Olusegun), Olusanya, B. O. (Bolajoko Olubukunola), Onwujekwe, O. E. (Obinna E.), Ortega-Altamirano, D. V. (Doris, V), Osarenotor, O. (Osayomwanbo), Osei, F. B. (Frank B.), Owolabi, M. O. (Mayowa O.), Mahesh, P. A. (P. A.), Padubidri, J. R. (Jagadish Rao), Pakhale, S. (Smita), Pana, A. (Adrian), Park, E.-K. (Eun-Kee), Patel, S. K. (Sangram Kishor), Pathak, A. (Ashish), Patle, A. (Ajay), Paulos, K. (Kebreab), Pepito, V. C. (Veincent Christian Filipino), Perico, N. (Norberto), Pervaiz, A. (Aslam), Pescarini, J. M. (Julia Moreira), Pesudovs, K. (Konrad), Pham, H. Q. (Hai Quang), Pigott, D. M. (David M.), Pilgrim, T. (Thomas), Pirsaheb, M. (Meghdad), Poljak, M. (Mario), Pollock, I. (Ian), Postma, M. J. (Maarten J.), Pourmalek, F. (Farshad), Pourshams, A. (Akram), Prada, S. I. (Sergio, I), Preotescu, L. (Liliana), Quintana, H. (Hedley), Rabiee, N. (Navid), Rabiee, M. (Mohammad), Radfar, A. (Amir), Rafiei, A. (Alireza), Rahim, F. (Fakher), Rahimi, S. (Siavash), Rahimi-Movaghar, V. (Vafa), Rahman, M. A. (Muhammad Aziz), Rahman, M. H. (Mohammad Hifz Ur), Rajati, F. (Fatemeh), Ranabhat, C. L. (Chhabi Lal), Rao, P. C. (Puja C.), Rasella, D. (Davide), Rath, G. K. (Goura Kishor), Rawaf, S. (Salman), Rawal, L. (Lal), Rawasia, W. F. (Wasiq Faraz), Remuzzi, G. (Giuseppe), Renjith, V. (Vishnu), Renzaho, A. M. (Andre M. N.), Resnikoff, S. (Serge), Riahi, S. M. (Seyed Mohammad), Ribeiro, A. I. (Ana Isabel), Rickard, J. (Jennifer), Roever, L. (Leonardo), Ronfani, L. (Luca), Rubagotti, E. (Enrico), Rubino, S. (Salvatore), Saad, A. M. (Anas M.), Sabour, S. (Siamak), Sadeghi, E. (Ehsan), Moghaddam, S. S. (Sahar Saeedi), Safari, Y. (Yahya), Sagar, R. (Rajesh), Sahraian, M. A. (Mohammad Ali), Sajadi, S. M. (S. Mohammad), Salahshoor, M. R. (Mohammad Reza), Salam, N. (Nasir), Saleem, A. (Ahsan), Salem, H. (Hosni), Salem, M. R. (Marwa Rashad), Salimi, Y. (Yahya), Salimzadeh, H. (Hamideh), Samy, A. M. (Abdallah M.), Sanabria, J. (Juan), Santos, I. S. (Itamar S.), Santric-Milicevic, M. M. (Milena M.), Sao Jose, B. P. (Bruno Piassi), Saraswathy, S. Y. (Sivan Yegnanarayana Iyer), Sarrafzadegan, N. (Nizal), Sartorius, B. (Benn), Sathian, B. (Brijesh), Sathish, T. (Thirunavukkarasu), Satpathy, M. (Maheswar), Sawhney, M. (Monika), Sayyah, M. (Mehdi), Sbarra, A. N. (Alyssa N.), Schaeffer, L. E. (Lauren E.), Schwebel, D. C. (David C.), Senbeta, A. M. (Anbissa Muleta), Senthilkumaran, S. (Subramanian), Sepanlou, S. G. (Sadaf G.), Servan-Mori, E. (Edson), Shafieesabet, A. (Azadeh), Shaheen, A. A. (Amira A.), Shahid, I. (Izza), Shaikh, M. A. (Masood Ali), Shalash, A. S. (Ali S.), Shams-Beyranvand, M. (Mehran), Shamsi, M. (MohammadBagher), Shamsizadeh, M. (Morteza), Shannawaz, M. (Mohammed), Sharafi, K. (Kiomars), Sharma, R. (Rajesh), Sheikh, A. (Aziz), Shetty, B. S. (B. Suresh Kumar), Shiferaw, W. S. (Wondimeneh Shibabaw), Shigematsu, M. (Mika), Shin, J. I. (Jae Il), Shiri, R. (Rahman), Shirkoohi, R. (Reza), Shivakumar, K. M. (K. M.), Si, S. (Si), Siabani, S. (Soraya), Siddiqi, T. J. (Tariq Jamal), Silva, D. A. (Diego Augusto Santos), Singh, V. (Virendra), Singh, N. P. (Narinder Pal), Singh, B. B. (Balbir Bagicha Singh), Singh, J. A. (Jasvinder A.), Singh, A. (Ambrish), Sinha, D. N. (Dhirendra Narain), Sisay, M. M. (Malede Mequanent), Skiadaresi, E. (Eirini), Smith, D. L. (David L.), Filho, A. M. (Adauto Martins Soares), Sobhiyeh, M. R. (Mohammad Reza), Sokhan, A. (Anton), Soriano, J. B. (Joan B.), Sorrie, M. B. (Muluken Bekele), Soyiri, I. N. (Ireneous N.), Spurlock, E. E. (Emma Elizabeth), Sreeramareddy, C. T. (Chandrashekhar T.), Sudaryanto, A. (Agus), Sufiyan, M. B. (Mu'awiyyah Babale), Suleria, H. A. (Hafiz Ansar Rasul), Sykes, B. L. (Bryan L.), Tabares-Seisdedos, R. (Rafael), Tabuchi, T. (Takahiro), Tadesse, D. B. (Degena Bahrey), Tarigan, I. U. (Ingan Ukur), Taye, B. (Bineyam), Tefera, Y. M. (Yonatal Mesfin), Tehrani-Banihashemi, A. (Arash), Tekelemedhin, S. W. (Shishay Wahdey), Tekle, M. G. (Merhawi Gebremedhin), Temsah, M.-H. (Mohamad-Hani), Tesfay, B. E. (Berhe Etsay), Tesfay, F. H. (Fisaha Haile), Tessema, Z. T. (Zemenu Tadesse), Thankappan, K. R. (Kavumpurathu Raman), ThekkePurakkal, A. S. (Akhil Soman), Thomas, N. (Nihal), Thompson, R. L. (Robert L.), Thomson, A. J. (Alan J.), Topor-Madry, R. (Roman), Tovani-Palone, M. R. (Marcos Roberto), Traini, E. (Eugenio), Ullah, I. (Irfan), Unnikrishnan, B. (Bhaskaran), Usman, M. S. (Muhammad Shariq), Uthman, O. A. (Olalekan A.), Uzochukwu, B. S. (Benjamin S. Chudi), Valdez, P. R. (Pascual R.), Varughese, S. (Santosh), Veisani, Y. (Yousef), Violante, F. S. (Francesco S.), Vollmer, S. (Sebastian), Whawariat, F. G. (Feleke Gebremeskel), Waheed, Y. (Yasir), Wallin, M. T. (Mitchell Taylor), Wang, Y.-P. (Yuan-Pang), Wang, Y. (Yafeng), Wangdi, K. (Kinley), Weiss, D. J. (Daniel J.), Weldesamuel, G. T. (Girmay Teklay), Werkneh, A. A. (Adhena Ayaliew), Westerman, R. (Ronny), Wiangkham, T. (Taweewat), Wiens, K. E. (Kirsten E.), Wijeratne, T. (Tissa), Wiysonge, C. S. (Charles Shey), Wolde, H. F. (Haileab Fekadu), Wondafrash, D. Z. (Dawit Zewdu), Wonde, T. E. (Tewodros Eshete), Worku, G. T. (Getasew Taddesse), Yadollahpour, A. (Ali), Jabbari, S. H. (Seyed Hossein Yahyazadeh), Yamada, T. (Tomohide), Yaseri, M. (Mehdi), Yatsuya, H. (Hiroshi), Yeshaneh, A. (Alex), Yilma, M. T. (Mekdes Tigistu), Yip, P. (Paul), Yisma, E. (Engida), Yonemoto, N. (Naohiro), Younis, M. Z. (Mustafa Z.), Yousof, H. S. (Hebat-Allah Salah A.), Yu, C. (Chuanhua), Yusefzadeh, H. (Hasan), Zadey, S. (Siddhesh), Moghadam, T. Z. (Telma Zahirian), Zaidi, Z. (Zoubida), Bin Zaman, S. (Sojib), Zamani, M. (Mohammad), Zandian, H. (Hamed), Zar, H. J. (Heather J.), Zerfu, T. A. (Taddese Alemu), Zhang, Y. (Yunquan), Ziapour, A. (Arash), Zodpey, S. (Sanjay), Zuniga, Y. M. (Yves Miel H.), Hay, S. I. (Simon, I), and Reiner, R. C. (Robert C., Jr.)

Abstract

Background: Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities. Methods: We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs. Findings: Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40·0% (95% uncertainty interval [UI] 39·4–40·7) to 50·3% (50·0–50·5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46·3% (95% UI 46·1–46·5) in 2017, compared with 28·7% (28·5–29·0)

Published
2020

39. Comparison of four inverse modelling systems applied to the estimation of HFC-125, HFC-134a, and SF6 emissions over Europe

Author

Brunner, D., Arnold, T., Henne, S., Manning, A., Thompson, R. L., Maione, M., O'Doherty, S., and Reimann, S.

Subjects
lcsh:Chemistry, lcsh:QD1-999, lcsh:Physics, lcsh:QC1-999
Abstract

Hydrofluorocarbons (HFCs) are used in a range of industrial applications and have largely replaced previously used gases (CFCs and HCFCs). HFCs are not ozone-depleting but have large global warming potentials and are, therefore, reported to the United Nations Framework Convention on Climate Change (UNFCCC). Here, we use four independent inverse models to estimate European emissions of the two HFCs contributing the most to global warming (HFC-134a and HFC-125) and of SF6 for the year 2011. Using an ensemble of inverse models offers the possibility to better understand systematic uncertainties in inversions. All systems relied on the same measurement time series from Jungfraujoch (Switzerland), Mace Head (Ireland), and Monte Cimone (Italy) and the same a priori estimates of the emissions, but differed in terms of the Lagrangian transport model (FLEXPART, NAME), inversion method (Bayesian, extended Kalman filter), treatment of baseline mole fractions, spatial gridding, and a priori uncertainties. The model systems were compared with respect to the ability to reproduce the measurement time series, the spatial distribution of the posterior emissions, uncertainty reductions, and total emissions estimated for selected countries. All systems were able to reproduce the measurement time series very well, with prior correlations between 0.5 and 0.9 and posterior correlations being higher by 0.05 to 0.1. For HFC-125, all models estimated higher emissions from Spain + Portugal than reported to UNFCCC (median higher by 390 %) though with a large scatter between individual estimates. Estimates for Germany (+140 %) and Ireland (+850 %) were also considerably higher than UNFCCC, whereas the estimates for France and the UK were consistent with the national reports. In contrast to HFC-125, HFC-134a emissions from Spain + Portugal were broadly consistent with UNFCCC, and emissions from Germany were only 30 % higher. The data suggest that the UK over-reports its HFC-134a emissions to UNFCCC, as the model median emission was significantly lower, by 50 %. An overestimation of both HFC-125 and HFC-134a emissions by about a factor of 2 was also found for a group of eastern European countries (Czech Republic + Poland + Slovakia), though with less confidence since the measurement network has a low sensitivity to these countries. Consistent with UNFCCC, the models identified Germany as the highest national emitter of SF6 in Europe, and the model median emission was only 1 % lower than the UNFCCC numbers. In contrast, the model median emissions were 2–3 times higher than UNFCCC numbers for Italy, France, and Spain + Portugal. The country-aggregated emissions from the different models often did not overlap within the range of the analytical uncertainties formally given by the inversion systems, suggesting that parametric and structural uncertainties are often dominant in the overall a posteriori uncertainty. The current European network of three routine monitoring sites for synthetic greenhouse gases has the potential to identify significant shortcomings in nationally reported emissions, but a denser network would be needed for more reliable monitoring of country-wide emissions of these important greenhouse gases across Europe.

Published
2017

41. Effects of extreme meteorological conditions in 2018 on European methane emissions estimated using atmospheric inversions.

Author

Thompson, R. L., Zwaaftink, C. D. Groot, Brunner, D., Tsuruta, A., Aalto, T., Raivonen, M., Crippa, M., Solazzo, E., Guizzardi, D., Regnier, P., and Maisonnier, M.

Subjects
*ATMOSPHERIC methane, *METHANE, *SOIL moisture, *SOIL temperature
Abstract

The effect of the 2018 extreme meteorological conditions in Europe on methane (CH4) emissions is examined using estimates from four atmospheric inversions calculated for the period 2005-2018. For most of Europe, we find no anomaly in 2018 compared to the 2005-2018 mean. However, we find a positive anomaly for the Netherlands in April, which coincided with positive temperature and soil moisture anomalies suggesting an increase in biogenic sources. We also find a negative anomaly for the Netherlands for September-October, which coincided with a negative anomaly in soil moisture, suggesting a decrease in soil sources. In addition, we find a positive anomaly for Serbia in spring, summer and autumn, which coincided with increases in temperature and soil moisture, again suggestive of changes in biogenic sources, and the annual emission for 2018 was 33±38% higher than the 2005-2017 mean. These results indicate that CH4 emissions fromareas where the natural source is thought to be relatively small can still vary due to meteorological conditions. At the European scale though, the degree of variability over 2005-2018 was small, and there was negligible impact on the annual CH4 emissions in 2018 despite the extreme meteorological conditions. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Correction to: Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy

Author

Griffiths, E. A., Hodson, J., Vohra, R. S., Marriott, P., Katbeh, T., Zino, S., Nassar, A. H. M., Kirkham, A. J., Pasquali, S., Johnstone, M., Spreadborough, P., Alderson, D., Fenwick, S., Elmasry, M., Nunes, Q. M., Kennedy, D., Khan, R. B., Khan, M. A. S., Magee, C. J., Jones, S. M., Mason, D., Parappally, C. P., Mathur, P., Saunders, M., Jamel, S., Haque, S. U., Zafar, S., Shiwani, M. H., Samuel, N., Dar, F., Jackson, A., Lovett, B., Dindyal, S., Winter, H., Fletcher, T., Rahman, S., Wheatley, K., Nieto, T., Ayaani, S., Youssef, H., Nijjar, R. S., Watkin, H., Naumann, D., Emesih, S., Sarmah, P. B., Lee, K., Joji, N., Lambert, J., Heath, J., Teasdale, R. L., Weerasinghe, C., Needham, P. J., Welbourn, H., Forster, L., Finch, D., Blazeby, J. M., Robb, W., Mcnair, A. G. K., Hrycaiczuk, A., Charalabopoulos, A., Kadirkamanathan, S., Tang, C. -B., Jayanthi, N. V. G., Noor, N., Dobbins, B., Cockbain, A. J., Nilsen-Nunn, A., de Siqueira, J., Pellen, M., Cowley, J. B., W. -M., Ho, Miu, V., White, T. J., Hodgkins, K. A., Kinghorn, A., Tutton, M. G., Al-Abed, Y. A., Menzies, D., Ahmad, A., Reed, J., Khan, S., Monk, D., Vitone, L. J., Murtaza, G., Joel, A., Brennan, S., Shier, D., Zhang, C., Yoganathan, T., Robinson, S. J., Mccallum, I. J. D., Jones, M. J., Elsayed, M., Tuck, L., Wayman, J., Carney, K., Aroori, S., Hosie, K. B., Kimble, A., Bunting, D. M., Fawole, A. S., Basheer, M., Dave, R. V., Sarveswaran, J., Jones, E., Kendal, C., Tilston, M. P., Gough, M., Wallace, T., Singh, S., Mockford, J. D. K. A., Issa, E., Shah, N., Chauhan, N., Wilson, T. R., Forouzanfar, A., Wild, J. R. L., Nofal, E., Bunnell, C., Madbak, K., Rao, S. T. V., Devoto, L., Siddiqi, N., Khawaja, Z., Hewes, J. C., Gould, L., Chambers, A., Rodriguez, D. U., Sen, G., Robinson, S., Bartlett, F., Rae, D. M., Stevenson, T. E. J., Sarvananthan, K., Dwerryhouse, S. J., Higgs, S. M., Old, O. J., Hardy, T. J., Hornby, R. S. S. T., Keogh, K., Frank, L., Al-Akash, M., Upchurch, E. 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Subjects
Adult, Male, operative difficulty, medicine.medical_specialty, MEDLINE, cholecystectomy, difficulty grading, laparoscopic, Surgery, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Internal medicine, medicine, Humans, Prospective Studies, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Laparoscopic cholecystectomy, Aged, business.industry, General surgery, Correction, Hepatology, Length of Stay, Middle Aged, Conversion to Open Surgery, Cholecystectomy, Laparoscopic, ROC Curve, 030220 oncology & carcinogenesis, Multivariate Analysis, 030211 gastroenterology & hepatology, Female, business, Grading scale, Abdominal surgery
Abstract

A reliable system for grading operative difficulty of laparoscopic cholecystectomy would standardise description of findings and reporting of outcomes. The aim of this study was to validate a difficulty grading system (Nassar scale), testing its applicability and consistency in two large prospective datasets.Patient and disease-related variables and 30-day outcomes were identified in two prospective cholecystectomy databases: the multi-centre prospective cohort of 8820 patients from the recent CholeS Study and the single-surgeon series containing 4089 patients. Operative data and patient outcomes were correlated with Nassar operative difficultly scale, using Kendall's tau for dichotomous variables, or Jonckheere-Terpstra tests for continuous variables. A ROC curve analysis was performed, to quantify the predictive accuracy of the scale for each outcome, with continuous outcomes dichotomised, prior to analysis.A higher operative difficulty grade was consistently associated with worse outcomes for the patients in both the reference and CholeS cohorts. The median length of stay increased from 0 to 4 days, and the 30-day complication rate from 7.6 to 24.4% as the difficulty grade increased from 1 to 4/5 (both p 0.001). In the CholeS cohort, a higher difficulty grade was found to be most strongly associated with conversion to open and 30-day mortality (AUROC = 0.903, 0.822, respectively). On multivariable analysis, the Nassar operative difficultly scale was found to be a significant independent predictor of operative duration, conversion to open surgery, 30-day complications and 30-day reintervention (all p 0.001).We have shown that an operative difficulty scale can standardise the description of operative findings by multiple grades of surgeons to facilitate audit, training assessment and research. It provides a tool for reporting operative findings, disease severity and technical difficulty and can be utilised in future research to reliably compare outcomes according to case mix and intra-operative difficulty.

Published
2018

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